JPS54106490A - Propargylglycine derivative and its preparation - Google Patents

Propargylglycine derivative and its preparation

Info

Publication number
JPS54106490A
JPS54106490A JP1341378A JP1341378A JPS54106490A JP S54106490 A JPS54106490 A JP S54106490A JP 1341378 A JP1341378 A JP 1341378A JP 1341378 A JP1341378 A JP 1341378A JP S54106490 A JPS54106490 A JP S54106490A
Authority
JP
Japan
Prior art keywords
formula
amino
compound
group
propargylglycine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP1341378A
Other languages
Japanese (ja)
Inventor
Yasuo Fujimoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Chemiphar Co Ltd
Original Assignee
Nippon Chemiphar Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Chemiphar Co Ltd filed Critical Nippon Chemiphar Co Ltd
Priority to JP1341378A priority Critical patent/JPS54106490A/en
Publication of JPS54106490A publication Critical patent/JPS54106490A/en
Pending legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

NEW MATERIAL:A propargylglycine derivative of formula I: [X is (CH3)2, formula IV (R3 is H, or acetoxy group); R1 is H, lower alkylcarbonyl, 4-lower alkyl-2,3-dioxo-1-piperazynocarbonyl group, etc,; R2 is H or alkyl group], and its non-toxic salt.
EXAMPLE: 6-(α-amino-α-propargylacetamido) penicillanic acid.
USE: Antibacterials.
PROCESS: A compound of formula II: (R4 is R1, amino-protecting group) or its reactive derivation is reacted with a compound of formula III: (R5 is H or ester residue) or its salt in a solvent, e.g. THF or acetone, preferably at -20°C to room temperature, and, if necessary, the amino-protecting group is removed to give the compound of formula I. When an acid is formed by the reaction, a base, e.g. alkali carbonate or picoline is added.
COPYRIGHT: (C)1979,JPO&Japio
JP1341378A 1978-02-10 1978-02-10 Propargylglycine derivative and its preparation Pending JPS54106490A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP1341378A JPS54106490A (en) 1978-02-10 1978-02-10 Propargylglycine derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1341378A JPS54106490A (en) 1978-02-10 1978-02-10 Propargylglycine derivative and its preparation

Publications (1)

Publication Number Publication Date
JPS54106490A true JPS54106490A (en) 1979-08-21

Family

ID=11832442

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1341378A Pending JPS54106490A (en) 1978-02-10 1978-02-10 Propargylglycine derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS54106490A (en)

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