JPS51126281A - Cytootoxic substance - Google Patents

Cytootoxic substance

Info

Publication number
JPS51126281A
JPS51126281A JP51010786A JP1078676A JPS51126281A JP S51126281 A JPS51126281 A JP S51126281A JP 51010786 A JP51010786 A JP 51010786A JP 1078676 A JP1078676 A JP 1078676A JP S51126281 A JPS51126281 A JP S51126281A
Authority
JP
Japan
Prior art keywords
cytootoxic
substance
cytootoxic substance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP51010786A
Other languages
Japanese (ja)
Inventor
Fuaadeinando Rourando Jiyooji
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB4695/75A external-priority patent/GB1496011A/en
Application filed by GD Searle LLC filed Critical GD Searle LLC
Publication of JPS51126281A publication Critical patent/JPS51126281A/en
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/44Antibodies bound to carriers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6883Polymer-drug antibody conjugates, e.g. mitomycin-dextran-Ab; DNA-polylysine-antibody complex or conjugate used for therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Peptides Or Proteins (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
JP51010786A 1975-02-04 1976-02-03 Cytootoxic substance Pending JPS51126281A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB4695/75A GB1496011A (en) 1974-11-22 1975-02-04 Defoaming composition

Publications (1)

Publication Number Publication Date
JPS51126281A true JPS51126281A (en) 1976-11-04

Family

ID=9782062

Family Applications (1)

Application Number Title Priority Date Filing Date
JP51010786A Pending JPS51126281A (en) 1975-02-04 1976-02-03 Cytootoxic substance

Country Status (5)

Country Link
JP (1) JPS51126281A (en)
BE (1) BE838273A (en)
DK (1) DK43676A (en)
NL (1) NL7601132A (en)
SE (1) SE7601125L (en)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57143326A (en) * 1981-03-03 1982-09-04 Teijin Ltd Polymer linked to cellular toxic substance and its preparation
JPS57197295A (en) * 1981-05-08 1982-12-03 Erba Carlo Spa Manufacture of daunorubicin-protein composite body
JPS60172935A (en) * 1984-02-16 1985-09-06 Green Cross Corp:The Preparation of composite material of substance having carcinostatic action
JPS611622A (en) * 1984-06-14 1986-01-07 Teijin Ltd Cytotoxic complex and preparation thereof
WO1987004171A1 (en) * 1985-12-27 1987-07-16 Teijin Limited Process for preparing antibody complex
WO1988001513A1 (en) * 1986-08-28 1988-03-10 Teijin Limited Cytocidal antibody complex and process for its preparation
JPH03287545A (en) * 1990-03-31 1991-12-18 Res Dev Corp Of Japan Target-directing polymeric drug compound and intermediate thereof
JPH0662438B1 (en) * 1986-08-28 1994-08-17 Teijin Ltd
JPH0688913B2 (en) * 1988-08-19 1994-11-09 タノックス・バイオシステムズ・インコーポレーテッド Molecular conjugate containing cell membrane blending agent

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2586564B1 (en) * 1985-09-04 1989-04-07 Pierre Tran Ba Loc IMMUNOSUPPRESSIVE COMPOUNDS AND PROCESS FOR THEIR PREPARATION

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57143326A (en) * 1981-03-03 1982-09-04 Teijin Ltd Polymer linked to cellular toxic substance and its preparation
JPS57197295A (en) * 1981-05-08 1982-12-03 Erba Carlo Spa Manufacture of daunorubicin-protein composite body
JPS60172935A (en) * 1984-02-16 1985-09-06 Green Cross Corp:The Preparation of composite material of substance having carcinostatic action
JPS611622A (en) * 1984-06-14 1986-01-07 Teijin Ltd Cytotoxic complex and preparation thereof
WO1987004171A1 (en) * 1985-12-27 1987-07-16 Teijin Limited Process for preparing antibody complex
WO1988001513A1 (en) * 1986-08-28 1988-03-10 Teijin Limited Cytocidal antibody complex and process for its preparation
JPH0662438B1 (en) * 1986-08-28 1994-08-17 Teijin Ltd
JPH0688913B2 (en) * 1988-08-19 1994-11-09 タノックス・バイオシステムズ・インコーポレーテッド Molecular conjugate containing cell membrane blending agent
JPH03287545A (en) * 1990-03-31 1991-12-18 Res Dev Corp Of Japan Target-directing polymeric drug compound and intermediate thereof

Also Published As

Publication number Publication date
NL7601132A (en) 1976-08-06
DK43676A (en) 1976-08-05
BE838273A (en) 1976-08-04
SE7601125L (en) 1976-08-05

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