JPH11304665A - Case for transportation, protection and storage - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a case that has simple structure and can be manufactured inexpensively, but enables a target such as blood to be taken out without touching it with hands and can carry, protect, and store the target safety and securely. SOLUTION: A target retaining container 10 for retaining and carrying a target consists of a target retaining region 11 for detachably retaining a matrix material for retaining the target (a), a container bottom part 12 for accommodating the target retaining region 11 (b), and a container lid part 13 that is engaged to the container bottom part 12 and can cover the target retaining region 11. Then, the target retaining container 1 is obtained by forming it in one piece by a sheet-shaped material.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to samples used for clinical tests such as blood, serum, urine, other body fluids and feces, samples for environmental tests and food analysis, anticoagulants such as anticoagulants and enzyme inhibitors. Agent, matrix material such as filter paper containing target substances such as various inhibitors such as receptor inhibitors,
The present invention relates to a case (container) that can be transported, protected, and stored safely and without causing contamination. On the other hand, in another aspect, the present invention can be easily manufactured and, despite having an extremely simple structure, can be easily applied without touching an object included in the matrix material. The present invention relates to a case (container) that enables the object to be transported, protected, and stored, and that can be quickly removed.

[0002]

2. Description of the Related Art Blood, saliva, urine, cerebrospinal fluid, ascites,
Various measurement tests for diagnosis and the like using body fluids such as tears have been developed and widely used for prevention, diagnosis and treatment of diseases. In particular, recently, various measures have been devised so that such measurement and inspection can be performed efficiently using a body fluid that can be obtained in a relatively small amount or only a small amount, and research and development have been carried out to obtain a reliable measurement result. . Since blood circulates through the body, it contains components that reflect various symptoms of the body. By measuring and testing various components contained in the blood accurately and quickly, blood is quickly and accurately determined. Diagnosis of diseases and the like can be performed, and can be used for prevention and treatment of the diseases. Conventionally, when conducting a clinical test using a component sample such as blood collected from the human body, the collected blood is first mixed with an anticoagulant such as heparin, sodium EDTA, sodium citrate, and centrifuged. Separate the blood plasma component into a sample, or coagulate the blood cell component without mixing with an anticoagulant, separate the serum component by centrifugation into a sample, and dispense it into glass or plastic spitz and store it. They were stored at different temperatures and sent to an inspection organization (inspection room).

In such a case, an operation of separating a sample component from blood, an operation of separating a sample component and dispensing the sample component into a storage container are performed, and packed and transported according to the storage temperature of room temperature, refrigeration and freezing. Was sent to the institution (inspection room). By the way, when measuring components in blood, usually, a blood clot and a serum component are separated and then a measurement test suitable for each component is performed. When blood is collected, the blood cell components immediately form aggregates (blood clots), but these aggregates may take up specific serum components and affect the measurement results, It is generally desirable to perform such a separation process as soon as blood is collected, as some may lyse and interfere with the determination of components in serum. In particular, serum obtained from blood is frequently used for such analysis and is an important specimen sample. Normally, this serum is collected at a hospital by venipuncture using a special sterile blood collection syringe or blood collection set to collect at least 5 cc or more of blood, and then centrifuged under cooling to obtain the serum component therefrom. ing. Such a method requires specialized techniques and requires a dangerous venipuncture in some aspects, and furthermore requires a centrifugal separator, which is practically impracticable outside hospitals and very inconvenient. In addition, since a blood collection tube (test tube) is used, the sample is bulky, and the sample is stored in a liquid state or transported, so that handling is inconvenient. In analysis and measurement using many serum samples, the measurement can be performed sufficiently with a small amount of serum, for example, about 1/5 to 1/10 of a drop of blood. Therefore, there is a demand for collecting a large amount of blood unnecessarily and without causing a problem such as invasion, and simply and safely collecting a small amount of blood for use in various measurement tests. There is also a strong demand for such a small amount of blood sample to be easily handled in a hospital easily and for a large number of samples, or to enable individuals to easily collect blood.

[0004]

In infants and young children, special skills are required for blood collection, and it is difficult to collect blood using a normal blood collection tool. Therefore, a disposable blood collection tool called a "lancet" is used. Normally, only a small amount of blood, such as one or two drops, can be collected (for example, Toshiyuki Toya, Examination and Technology, Vol. 23, No. 8,
pp 601-605, 1995). It is practically impossible to subject the whole blood thus obtained to separation means such as centrifugation, and therefore cannot be separated into blood clots and blood serum mainly containing blood cell components. It was practically impossible to perform a normal test measurement using the obtained serum sample. Further, recently, the amount of a sample used for a clinical test has been miniaturized due to high accuracy and high sensitivity of a test method. Among them, a body fluid material such as blood or serum is infiltrated into a filter paper cut to a certain size according to the test item to make a specimen, and the serum components excluding blood cells and coagulation components that have clotted during the test are redissolved. A simple method is used as a test material, and a filter paper containing such blood is used as a specimen. It is necessary to keep the sample in a more stable form without substantially altering it until it is collected or subjected to measurement or examination, but it is particularly easy to cause such alteration in fluids such as body fluids. Although it is difficult to keep the same state as the state at the time of the treatment, it is required that the body fluid sample can be kept in a more stable form (for example, Seiraga Eiraku et al., Pediatric Internal Medicine, Vol. 1).
2, No. 8, pp1287-1297, 1980;
Teruo Kitagawa et al., Pediatrics, Vol. 12, No. 8, p
p1265-1270, 1980). Thus, recently, various kinds of specimens or samples are supported on filter paper or the like, and a method of holding, protecting, or transporting the specimen to the inspection department has been studied.

[0005] Furthermore, when a blood sample is stored or transported as a liquid, there is also a problem that the liquid sample must be handled with care because it is a liquid. In recent years, each sample has been automatically managed and tested using a computer, etc., along with basic information such as the subject's name, age, and gender, and information on test request items. There is also a need for the development of containers that are suitable for this purpose and that are suitable for attaching bar codes with high density and high information content. Due to recent medical sophistication, environmental degradation, emission of many chemical substances, etc., it has become necessary to handle a large number of samples, although in small quantities. Such a sample, by its nature, contains many dangerous substances such as blood contaminated with hepatitis virus, HIV virus, etc., and ash containing dioxin, and it is often difficult to determine that the substance is dangerous. In order to store, protect and transport such samples, they need to be relatively small in size and have a number of the required properties as described above. In other words, it should be easy to manufacture at a low cost with a simple structure, there should be little concern that the sample to be transported would be contaminated or contaminated by it, or leaked out of the container. It is not necessary to touch it when taking it out, sampling can be performed easily and safely and accurately, that the container is not bulky, and that it can be easily discarded. Thus, there is a need for a container that can safely, easily and reliably transport, protect, and store a filter paper or the like impregnated with a sample such as blood. In addition, some of them contain a certain amount of moisture, so there is a need for a container that can handle such moisture. In addition, since many such samples need to be processed, their operation must be simple and reliable, and must be safe and inexpensive.

[0006]

Means for Solving the Problems The inventors of the present invention have made intensive studies to solve the above-mentioned problems, and as a result, they can be manufactured easily with a simple structure, but the required structure is ensured while ensuring sufficient safety. By designing a case (container) with an operable structure, it was recognized that these were suitable for the above purpose. The present inventors can further easily and safely handle an object such as a small amount of blood over a wide area, and can easily carry or handle the object, and use only the sheet portion with the object at the time of measurement. The inventors have found that the present invention can be cut out and used for measurement, that such a method can be easily and safely performed, and that the amount of a sample used for a test can be easily adjusted.

That is, the present invention provides: [1] An object holding container capable of holding and transporting an object, wherein (a) a matrix material capable of holding the object is detachably held. (B) a container bottom capable of accommodating the object holding area, (c) a container lid capable of engaging with the container bottom and covering the object holding area Wherein the object-holding container is obtained by integrally forming and processing the sheet-like material; [2] a group in which the sheet-like material is made of plastic, paper and cloth The object holding container according to the above [1], wherein the sheet-like material is paper or cloth processed with a water-repellent material. [1] The object holding container according to [1];

[4] The object holding region has (i) a convex region, and (ii) at least a part of the convex region is formed of an edge of a matrix material capable of holding the object. And (iii) the matrix material holding portion is capable of easily cutting the matrix material holding the object by punching. (4) The object holding container according to the above (1), wherein a hole region is provided so as to be closed, and (iv) the hole region is smaller than a size of a matrix material to be held; The object holding area is (v) the object holding area can be easily detached from the bottom of the container in order to be able to cut out by punching while holding the matrix material holding the object. So that the above item [1], characterized in that it has a grip portion object container according;

[6] The container bottom has a convex region, and at least a part of the convex region engages with an edge of the object holding region to detachably attach the object holding region. And at least a portion of the convex region engages at least a portion of the concave region of the container lid to cover the object holding region and remove matrix material from the external environment. The object holding container according to the above [1], wherein the container can be shielded; [7] The container lid has a concave region, and at least a part of the concave region is a container. The object holding device according to the above [1], wherein the object holding device is engaged with at least a part of the bottom convex region to cover the object holding region and shield the matrix material from an external environment. Vessel; [8] Structure shown in FIGS. Alternatively object holding vessel [1], wherein the it in substantially those selected from the group consisting of those having a structure having the same function; and

[9] In an object holding container capable of holding and transporting an object, (a) a matrix material capable of holding the object, and (b) an object capable of detachably holding the matrix material. An object holding area, (c) a container bottom capable of housing the object holding area, (d) a container lid capable of engaging with the container bottom and covering the object holding area, The object holding container is provided by being integrally molded from a sheet material.

[0010] In another aspect, the present invention further provides [10] an object holding container 10 comprising an object holding region 11, a container bottom 12 and a container lid 13, wherein the container bottom 12 has a convex region 23 Is provided so as to roughly surround a region 33 (of the container bottom 12) in which the object holding region 11 can be accommodated, and the object holding region 11 can hold an object. The convex regions 22 and 32 are provided so as to roughly surround the matrix material 51 so that the matrix material 51 can be detachably held. The object holding region 11 further includes a hole 42. Is provided at the region 41 for holding the matrix material 51,
Can be easily cut off by punching, etc.
The container lid portion 13 is provided with a concave region 25, and when the edge of the concave region 25 and the outer edge of the convex region 23 are engaged, covers and accommodates the object holding region 11. Providing an object holding container characterized in that the object holding container is obtained by integrally forming and processing a sheet-like material. It is.

[0011]

BEST MODE FOR CARRYING OUT THE INVENTION In the present invention, a relatively small or minute amount of a body fluid sample, particularly a blood sample, is protected, and it is not substantially contaminated, and furthermore, it is possible to stabilize it while minimizing deterioration. Means for storing, transporting and transporting, and simply and safely, and cheaper, are provided. The use of such means opens the way in which body fluid samples, particularly blood samples, which have been practically impossible so far, can be used for various measurements, tests, and analyzes for clinical or diagnostic purposes. The use of the means of the present invention makes it possible to handle a relatively small or minute amount of a body fluid sample, particularly a large number of blood samples, easily, inexpensively, and safely. The use of the sample protection container of the present invention can significantly save space and solve environmental problems such as disposal of used instruments.

The body fluids of the present invention include blood, plasma fluid, amniotic fluid, semen, exudate, leaked fluid, interstitial fluid, cerebrospinal fluid,
Examples include cerebroventricular fluid, saliva, urine, cerebrospinal fluid, ascites, tears, etc., and particularly whole blood, but are not particularly limited as long as they are liquid components derived from a living body that can be used for test and measurement. The bodily fluid of the present invention is
Preferably, whole blood is used. When fresh blood is allowed to stand, blood coagulation occurs, and then the blood cells and fibrin shrink lumps and a clear supernatant is released, which is called serum. Accordingly, the serum is a liquid component of blood, which is usually the whole blood excluding fibrin clots and blood cells, but is not particularly limited as long as it is a simple liquid component of blood that can be suitably used for test and measurement. Plasma refers to a liquid component of blood circulating in a living body, and corresponds to a portion obtained by removing red blood cells and other formed components from fresh whole blood,
Normally after blood collection, add an anticoagulant such as oxalate, citrate, ethylenediaminetetraacetic acid (EDTA) salt, or heparin, or keep the temperature low to prevent the progress of blood coagulation, and then leave or centrifuge. It refers to one obtained by separating and removing the formed components, but is not particularly limited as long as it is a liquid component of blood that can be suitably used for the test and measurement.

[0013] Thus, in the present invention, the objects include the above-mentioned bodily fluids, feces, cells, tissues, cell homogenates, tissue homogenates, cultures of cells and tissues or supernatants thereof, and nucleic acids such as animal and plant DNAs and RNAs. , Samples for food analysis, samples for water, soil, ash, etc. for environmental tests, as well as anticoagulants, reagents and compounds used for various tests and measurements, and the characteristics of the container of the present invention. It will be understood that there is no particular limitation as long as it can be used. The object can be solid, liquid, or semi-solid.

In the present invention, the matrix material capable of holding the object is not particularly limited as long as the object can be adhered or penetrated and / or adsorbed. Structural ones. In particular, examples of such a material include those which are structures made of fibers selected from the group consisting of natural polymers, synthetic polymers, and semi-synthetic polymers.
These include fabrics (eg, woven, knitted, etc.),
Non-woven fabric, filter paper, paper (paper can be selected from Western paper, Japanese paper, paperboard, and even chemical fiber paper can be used), cotton, sponge, natural / semi-synthetic
Synthetic polymer fiber structures and the like can be cited, but they can be widely used as long as required objects can be achieved. Natural
The semi-synthetic / synthetic polymer fiber structure is made of cellulose fiber or a synthetic polymer resin. Among these, the synthetic polymers include polyalkylene terephthalates such as polybutylene terephthalate, polyethylene terephthalate and polypropylene terephthalate, and polymethylpentene. , Polypropylene, polyalkylenes such as polyethylene, polyhexamethylene adipamide (nylon 66), nylon 6, nylon 610, nylon 7,
Various polyamides such as nylon 11 and nylon 12 and polycarbonates are exemplified. Preferably, such a polymer is used after being processed into a molded article (structure) in the form of a fiber sheet (fiber mat).

A sheet made of such a polymer fiber is
Those whose surface is grafted and modified so as to obtain a predetermined body fluid penetrating ability and / or adsorption ability by satisfactorily wetting the fiber sheet with the body fluid are preferably used. Those grafted to have as high a density of hydroxyl groups as possible on the surface of the fiber structure, those grafted so that hydroxyl groups and carboxyl groups are mixed, those grafted such that hydroxyl groups and methyl groups are mixed, Alternatively, there may be mentioned those grafted so as to have an amine group. A desirable process is also obtained by using monomers exhibiting hydroxyl groups and polymerizing these monomers in an aqueous environment. Those skilled in the art will readily be able to select what monomers to select and the conditions for how to perform the grafting depending on the purpose. Sheet (or fibrous structure) used in the present invention
Preferably, for example, a hydrophilic material made of a polyamide material is used. A typical example of such a polyamide is nylon. Preferred nylons include polyhexamethylene adipate, poly-ε-caprolactam, polymethylene sebacamide, poly-7-aminoheptanoamide, polyhexamethylene azelamide, and the like, and particularly preferred is polyhexamethylene adipamide. Pamide (nylon 66). More particularly preferred are non-cortical, substantially alcohol-insoluble hydrophilic polyamide materials. These sheets (fibers) can also preferably have a methylene CH ₂ : amide NHCO ratio in the range of about 5: 1 to about 7: 1.

In a particularly preferred embodiment, the present invention provides a simple and safe method for measuring small or minute amounts of body fluids.
The present invention also relates to a container capable of being stably transported and a method therefor. More preferably, the present invention relates to a container capable of transporting a trace amount of blood while maintaining a measurable state, and a method used therefor.
The invention makes it possible to keep a trace amount of blood measurable and / or to transport or store it. The present invention also relates to a storage container for a sample after blood separation, which is used when a clinical institution is outsourced from a medical institution (clinic) to a laboratory (laboratory) in a clinical test. According to the present invention, a relatively small or trace amount of body fluid, and more preferably, it is possible to examine components in blood from a collected blood in a case where only one or two drops are obtained, such as an infant or the like. , Transport, protection and preservation.

According to the present invention, a blood clot mainly containing blood cell components and a serum component can be separated without adding an anticoagulant or the like to the test blood, and the blood clot is separated and sent to a test facility. Transport. Furthermore, it is possible to easily secure the required amount for measurement or inspection in a laboratory. In addition, if necessary, a small amount of blood is treated with an anticoagulant, etc., separated into blood cell components and plasma components, and the separated components are kept in a separated state, making it easy and easy to reach a predetermined test location. To be able to move or save. According to the present invention,
By cutting and using a sheet fragment having an appropriate area, the required amount of the test sample component can be easily adjusted, and the collected blood is diluted with a physiological saline solution or a buffer solution or the like so as to be preferable for the test measurement. This makes it possible to omit the trouble of adjusting the density.

Hereinafter, the present invention will be described in detail with reference to Examples. However, the present invention is not limited to these Examples, and various embodiments are possible. It should be understood that all embodiments are included as long as they comply with the following. Referring now to the drawings, first shown generally at 10 in FIG.
And a container body constructed according to the invention is shown. The container body is in a preferred form for transporting, protecting and storing objects. The container 10 includes an object holding area 11, a container bottom 12, and a container lid 13. In FIG. 1, the container 10 is shown in a state where each component is expanded. That is, in FIG.
The object holding area 11, the container bottom part 12, and the container lid part 13 are arranged in order from the left side to the right side, and each of these constituent parts is manufactured by molding from a continuous material. I have. The present invention encompasses such features that the object holding area, the container bottom and the container lid are formed from a unitary material (or a single sheet of material) when the container body is unfolded. It may have. The container of the present invention typically includes a container that is arranged in order of an object holding area, a container bottom, and then a container lid.

When a container is used, the container body 10 is first bent at the bent portion 21 as shown in FIG. In a preferred example, the bend 21 can be perforated. Container bottom 12
A convex region 23 is provided in a U-shape, a concave region 22 ′ is provided in the object holding region 11 in a U-shape, and the container bottom 12
When folded to the side, it can be seen that the recessed region 22 'becomes a raised region 22 as the recess is inverted and can be seen with reference to FIG. It can be seen that the convex region 23 of the container bottom 12 engages with the edge of the object holding region 11 to enable the object holding region 11 to be detachably held. FIG.
In the specific example shown in (1), the handle portion 26 is provided so that the object holding area 11 can be easily taken out.

As can be seen with reference to FIG. 2, the object holding area 11 is provided with a convex ridge 32 (shown as a concave ridge 32 'in FIG. 1), and the convex area 22 And a surface on the side of the region 41, so that a matrix material such as filter paper can be detachably held. A hole 42 is provided in the area 41. FIG.
3 shows a state in which a matrix material 51 such as filter paper is attached to the region 41. The concave area 3 surrounded by the convex area 23 provided on the container bottom 12
3, when the object holding area 11 is bent toward the container bottom 12 at the bent portion 21, the object holding area 11 can be completely accommodated therein. In addition, although the convex region 23 is provided in a U-shape on the container bottom, it is needless to say that the convex region may be provided over the entire periphery of the container bottom.
In this case, if the length of the connecting region 27 from the bent portion 21 to the concave region 22 ′ is increased, the object holding region 11 is provided in the concave region 33 at the bottom of the container so as to straddle the convex region. It will be understood that it is possible to accommodate If necessary, a sponge or the like may be placed in a region surrounded by the convex region on the bottom of the container, so that the sponge or the like can be made to contain moisture or other liquid and transported in a wet state. sell. As can be seen with reference to FIG. 4, the container lid 13 is bent toward the container bottom 12 at the second bent portion 24, and the outer edge of the convex region 23 of the container bottom 12,
The edge of the concave region 25 (shown as a concave region in FIGS. 1, 2 and 3 and shown as a convex region 25 ′ in FIG. 4) provided in the container lid 13 Finally, as shown in FIG. 5 (a), a container is formed in which the object holding area 11 can be housed and protected. As is clear from FIG. 7, the base of the region 23 is provided with a shallow concave portion so that the lid can be fixed by engaging with a slight convex portion provided on the opening side on the outer peripheral side of the region 25. Has become. Since the container lid 13 has the convex region 25 ', the matrix material 51 held in the object holding region 11 can be transported, protected, and stored in a non-contact manner. . That is,
It will be understood that the container bottom 12 and the container lid 13 form a space for accommodating the object holding area 11 and the matrix material 51 held in the object holding area 11 together. The specific sizes of the regions 23, 22 'and 25 from the surface of the container body can be understood from FIGS. 7 to 9, but the depth depends on the material of the container body. It is also possible to appropriately change the shape according to the object to be housed in the container, and it is preferable to use a material that gives strength so that the shape of the container can be maintained.

In a typical example, the lateral length of the container body shown in FIG. 1 is 130-180 mm, more typically 160 mm, and its vertical size is the container lid. 13
40-60 mm, more typically 52 mm, container bottom 1
2, 40 to 60 mm, more typically 52 mm, and in the object holding area 11 25 to 35 mm, more typically 30 mm. In one example, the horizontal length of the container body in FIG.
The container lid 13 has a size of 52 × 52 mm, and the recessed area 25 has an opening of 43.67 (horizontal) × 43.68 (vertical) mm.
It is 4.6 × 44.6 mm and its depth is 5.3 mm. In the second bent portion 24, the distance between the container lid 13 and the container bottom 12 is 5 mm.
mm of which about 3 mm is curved to a depth of 1.5 mm to facilitate bending. The vertical width of the second bent portion 24 is 8 to 10 mm. In the container bottom part 12, the container body is 52
× 52 mm, the width of the top of the peak of the protrusion in the protrusion region 23 is 5.12
mm, 6 mm at the bottom, 5.3 mm deep, 33
× 33 mm. In the object holding area 11, the container body is 32
× 32 mm, a region 10 mm between the container bottom 12 and the object holding region 11 continuing to the bent portion 21, a region 12 mm in the opening side in the region 41, and a hole diameter of 12.31 mm in the container body side in the lateral direction. Is 10 mm, the depth of the region 22 is 3 mm, and the size on the outer peripheral side is about 30 × 30 mm.

For example, when the case (container) of the present invention is used to transport, protect, or preserve a sample or specimen for analysis / measurement as an object, as shown in FIG. 5 (b). On the outer surface of the container lid 13, a data application area for object management, for example, a label can be attached. When the container of the present invention is used, for example, for transporting, protecting, or preserving a sample or specimen for analysis and measurement as an object, the container lid 13 shown in FIG. 5A is opened. . Then, for example, an object such as blood, serum, or plasma is made to permeate and / or adsorb to the matrix material 51 such as filter paper shown in FIG. To transport, protect, or store, re-open the container lid 1
3 is closed as shown in FIG. 5 (a). The container of the present invention used for transporting, protecting, and preserving, for example, inspects and targets objects such as blood, serum, and plasma.
At the place where measurement and analysis are performed, the container lid 13 is opened. Next, the user grips the handle portion 26 to pull out the object holding region 11 and set the matrix material 51 such as filter paper at a position where the matrix material 51 can be easily sandwiched from both sides. Next, the matrix material 51 is cut out by punching. Since the holes 42 are provided in the object holding area 11, it is possible to easily cut out the pieces of the matrix material 51 by punching. In some cases, the entire matrix material 51 can be easily removed from the object holding area 11 by, for example, pressing the matrix material 51 from the back through the hole 42. The hole 42 may have a circular, elliptical, square,
Any form such as a triangle may be used. In short, it is possible to collect the object without directly touching the object,
It can be transported, protected and stored,
Furthermore, it is possible to take out the object without directly touching the object by hand. In particular, according to the present invention, it is possible, for example, to easily avoid the problem that the target object is contaminated by touching the target object, and to enable quantitative handling suitable for, for example, clinical examination. That is, for example, when cutting by punching, the amount of the sample can be freely adjusted by changing the size of the scissors for punching.

FIG. 6 is a front view showing one embodiment of the present invention. The rear view of the container is
It is understood that the front view and the object appear. In FIG.
A right side view of the embodiment shown in FIG. 6 is shown. It will be appreciated that the left side view of the container appears to be approximately the same as the right side view. FIG. 8 shows a cross-sectional view (the left side shows the front view direction) of the specific example shown in FIG. In the figure,
The leftmost figure shows the shape of the AA cross section, and the middle figure is B
-B shows the shape of the cross section, and the rightmost figure shows the shape of the CC cross section. FIG. 9 is a sectional view of the specific example shown in FIG.
(The upper side shows the front view direction), and the shape of the DD section is shown. The thin line shown in the figure indicates the shape of the background structure. FIG. 10 is a perspective view showing another embodiment of the present invention. Here, it can be seen that the object holding area 11 is configured to be able to hold two matrix materials 51 such as filter paper. FIG. 11 is a perspective view showing another embodiment of the present invention. Here, it is understood that a plurality of (three in the figure) object holding areas 11 are provided so that a plurality (three in the figure) of matrix materials 51 such as filter paper can be held. . FIG. 12 is a perspective view showing another embodiment of the present invention. Here, it can be seen that a circular hole is provided in the object holding area.
FIG. 13 is a diagram showing a case where a matrix material such as filter paper is detachably attached to the specific example shown in FIG. It will be appreciated that in this container it is possible to cut out multiple samples from the same matrix material. In this way, a plurality of matrix materials such as filter paper can be held, and in that case, the size of the container can be appropriately adjusted accordingly.

The container of the present invention can be used in any of a protective case, a storage case, and a transport case. In practice, the filter paper contains an anticoagulant or various inhibitors, and the filter paper is held in the container. Or a method of using a container such that a plurality of filter papers having different properties (for example, two or more types of filter papers) are stacked and held in a container. A container holding such filter paper is also a feature within the scope of the present invention.
Further, for example, by holding a matrix material such as a plurality of filter paper as shown in FIG. 10 or FIG.
The plurality of matrix materials may contain different anticoagulants or various inhibitors, or may contain inhibitors for different purposes to make them suitable for use in various applications. It is. As the sheet-like material constituting the container body of the present invention, plastic, paper,
Alternatively, a cloth or the like may be used, and a cloth having a certain strength may be used. Examples of the plastic include hard or soft plastics, which can be selected from thermosetting or thermoplastic plastics and those widely known in the field of containers. For example, polyolefin resins such as polyethylene and polypropylene, acrylate or methacrylate resins, terephthalate resins, styrene resins, and the like are preferable, and vinyl chloride and polyethylene terephthalate (PET) resins are particularly preferable. Paper and cloth can be processed with a water-repellent material. The water-repellent material can be selected from those widely known in the field of containers, and examples thereof include a synthetic resin such as a silicone resin and a fluoride resin. In the present invention, the container is obtained by integrally molding a sheet material, and preferably, all parts can be integrally formed at a time, for example, by punching the sheet material by a press. Therefore, the manufacturing method is also a feature of the present invention. The molding process is selected from those widely known in the art,
You can apply it. As is clear from the structure, it can be obtained by molding in a simple process using a mold or the like.

Surface 25 'of container lid 13 of the container of the present invention
Can be used effectively, and for example, a data addition area for object management can be provided. By giving the data for object management to the object in this way, the object such as the test sample is automatically managed, and the processing of the sample can be performed quickly and safely. For example, when an examination is requested, the “Inspection Request Form” usually includes basic information such as the subject's name, age, and gender, as well as necessary information such as examination request items and medical institution items such as chart numbers. ,
The sign (identification number, etc.) of this request form and the mark attached to the specimen are matched and handled. Laboratory laboratories manage inspection work and request information management (mainly managed by computer) separately. It is handled based on the identification code. Further, in the test result report, information is integrally described in the report so that it can be managed by a medical institution. As a general information management form in such a case, an identification symbol, a barcode, or a two-dimensional barcode in which information can be directly described is used.

In the container of the present invention, management information such as an identification symbol, a barcode, and a two-dimensional barcode in which information can be directly written is stored together with an object such as a specimen, and is stored, moved, or transported. Since it is possible to manage a large number of accurate objects such as specimens, it is possible to obtain results useful for more accurate clinical tests and the like. For example, identification can be easily performed by attaching a label describing patient (sample) information to one side of the container (information is information using a sample number or a barcode). In the clinical testing area, barcodes can be used to partially manage individual sample collection sites and date and time, etc., but also centralized management of samples by computer, clinical testing equipment and sample transport systems There is a further demand for improved analysis efficiency, automatic control of test accuracy, and automation of clinical tests by automatically identifying specimens to be analyzed by the method. In the field of clinical examination, management of individual identification and unique information is required more accurately than item identification of articles. In addition, the integration of objects (samples) and information (test results) using high-information-volume, high-density barcodes that can contribute to the promotion of information-related business related to medical care and to the enhancement of intelligent medical equipment is aimed at autonomous decentralization. Is also required in the construction of information management systems. In this way, in order to enable the immediacy of processing, self-sustained decentralized processing, and single item identification accuracy by integrating the information with the object in consideration of the effectiveness of the barcode,
There is a need to increase the information content and density of barcode symbols. The sample protection container of the present invention is suitable for using such a barcode symbol with a high information content and a high density.

In the case of a sample label applied to a conventional blood collection test tube, an error due to the curved wall of the test tube and further contamination (for example, contamination of the label with blood or a chemical solution, contamination of the label with a writing instrument, etc.). Due to the problem of securing restoration (security level) performance, there has been a limit in increasing the amount of information and increasing the density of barcode symbols. However, the container according to the present invention employs the surface 25 (in some cases) of the container lid 13. Can utilize the bottom surface 33 '(not shown) of the container, which is suitable for attaching high density and high information barcode symbols such as two-dimensional barcodes. Therefore, the present invention provides a container characterized in that a data addition area for managing an object such as a specimen is provided outside the container. In particular, the present invention provides the container, wherein a high-density and high-information-amount barcode symbol such as a two-dimensional barcode is provided in a data provision area for managing an object such as a specimen. Is done. The one-dimensional barcode is obtained by applying a one-dimensional visual system constituted by a stripe pattern formed by a combination of bars and spaces having different widths.
PC (JAN), Code39, Codabar, Interleaved 2 of 5, NW-7
And other barcode symbols. 2
The two-dimensional barcode is a two-dimensional matrix type or laminated barcode or symbol code.
e16K, Code49, PDF417, Codablock, Vercode, Data Cod
e, UPS Code and so on.

The information density and information capacity are determined by the amount of information to be applied and the attached area of the barcode attached object. In the container of the present invention, the barcode attached area can be provided with great flexibility. It is possible. Thus, it will be appreciated that the container of the present invention has excellent properties for attaching two-dimensional barcodes. By using a two-dimensional barcode, it is possible to manage a specimen with high density and high information amount, for example, it is possible to attach test request information and test result information, and conventionally, it was transmitted through an online system. By attaching the test request information to the container holding the sample, the sample and the information can be integrated and managed.Computer-readable information and long-term storage of the sample can be managed, and the previous value can be used as the dilution factor information. Can be directly transmitted to the analyzer. It is also possible to ensure data integrity and security.

The container of the present invention, which is provided with a data providing area for object management, and in particular, the container of the present invention to which information is attached by a bar code or the like, comprises a sample or the like. It is suitable for constructing an object transport system of the type described above, and is used in a system that automatically transports an object such as a sample to an automatic analyzer, and may greatly contribute to labor saving, labor saving, and speeding up. have. Furthermore, it is suitable to be applied to a clinical laboratory automation system. For the use of barcodes in the clinical test area, and for clinical tests and clinical test automation systems utilizing sample transport systems, see, for example, Shigeyoshi Tani, Barcodes, pp. 35-39, April 1993; And computer, V
ol. 6, no. 4, 2nd (298) to 8th (30
Page 4) and pages 38 (334) to 62 (357);
The contents described in July 1994 or the like can be referred to, and those contents are included in the contents of the present specification by reference herein.

For example, the container of the present invention thus used for storing and / or transporting an object and brought to the inspection and analysis department can be handled as follows when performing the inspection. First, the container lid portion 13 is opened, and the handle portion 26 is pulled to pull out the object holding region 11, and the matrix material 51 held in the object holding region 11 is pulled out from both sides to a position where it can be easily sandwiched. A matrix material, for example, a serum portion on the filter paper sheet is cut out together with the filter paper separation sheet with scissors for punching. The object holding area 11 has a hole 42 (a substantially circular shape in FIG. 1 and a circular shape in FIG. 12) so that the serum portion on the filter paper sheet can be easily cut off by punching. I have to. In particular, a required part used for inspection is selected and cut. The cut filter paper sheet, for example,
The test component held on the filter paper sheet is extracted into a liquid phase, and the sample thus obtained is subjected to required measurement and analysis. Since the entire matrix material is detachably held in the object holding area 11, it is also possible to take out the whole of the matrix material with tweezers or the like. In addition, a portion where a component desired to be used as a sample is located can be arbitrarily selected and cut and used.

The test component held on the sheet made of the matrix material is converted to a liquid phase substantially natively (nat).
ive) The extraction solvent or extraction method for performing this extraction is not particularly limited as long as the extraction can be performed. In terms of extracting as natively as possible, T
Buffers such as ris buffer and phosphate buffer (pH 6.8 to
It is preferred to use 7.6) as an extraction solvent. In terms of extraction efficiency, the extraction solvent preferably contains a surfactant (preferably, a nonionic surfactant such as Tween-20). The concentration of this surfactant is 0.1.
It is preferably about 1 to 0.5%. The extraction conditions are not particularly limited. For example, when a test component is held on a spot filter paper (thickness: about 1 mm) having a diameter of 3 mm,
The following conditions are preferably used. Extraction solvent: 0.1
~ Tris buffer containing 0.4% Tween-20 (0.
05-0.2 mol / L) or phosphate buffered saline Amount of solvent for extraction: 200-300 μL Extraction temperature: room temperature (about 25 ° C.) Extraction time: 1-4 hours The above explanation is mainly for the case of obtaining serum. As described above, when plasma or a plasma sample is obtained instead of serum, a sample that can be used for the test can be obtained by carrying out the same treatment, and the sample can be transported and stored.

The method of the measurement is not particularly limited as long as various measurements in the above-mentioned extract can be performed. The measurement of the analyte includes, for example, high performance liquid chromatography, electrophoresis, ultracentrifugation, colorimetry, precipitation, atomic absorption spectrometry, chemiluminescence, gas chromatography and the like.
For example, 41 kinds of various amino acids and imino acids are obtained by using 0-phthalaldehyde (OPTA) including 0-phthalaldehyde / N-acetyl-L-cysteine (OPTA / AcCys). The measurement can be performed efficiently by liquid chromatography and fluorescence analysis. In addition, a method utilizing a reaction having specificity such as an enzyme reaction or an antigen-antibody reaction can be used. Biochemical tests using enzymatic reaction include lipase, amylase, lysozyme, acid phosphatase, aldolase, serum alanine aminotransferase (AL
T [glutamate pyruvate transaminase; GP
T]), serum aspartate aminotransferase (AST [glutamate oxaloacetate transaminase; GOT]), cholinesterase (ChE), creatine kinase (CK), adenosine deaminase, lactate dehydrogenase (LDH), α-hydroxybutyrate dehydrogenase (Α-HBD), γ-glutamine transpeptidase (γ-GTP), leucine aminopeptidase (LA
Examples of the enzyme include P) and the like. Depending on the case, a specific synthetic substrate or a naturally occurring substrate may be used to directly measure the enzyme activity, or a conjugated enzyme may be used.

Also, a method utilizing specific binding, for example,
Methods utilizing complementary nucleic acid sequences, effectors and receptors, enzymes and inhibitors, receptors and ligands, complement binding reactions, reactions between antibodies and antigens, and the like can also be used. Examples of the method using the complementary nucleic acid sequence include a polymerase chain reaction (PCR) method, a reverse transcriptase polymerase polymerase chain reaction (RT-PCR) method, and an in situ method.
Hybridization, Southern blot hybridization, and the like. An immunological assay using an antigen-antibody reaction can be preferably used. Examples of the immunological assay include Western blotting, Ouchterlony, nephelometry, immunoelectrophoresis, latex agglutination immunoassay, hemagglutination, radioimmunoassay (RIA), enzyme immunoassay (EIA), Fluorescence immunoassay (FIA) and the like are available. In some cases, it is preferable to use a fluorescence immunoassay, particularly a time-resolved fluorescence immunoassay (TR-FIA) because high sensitivity can be easily obtained.

A test sample transported, protected and stored using the container of the present invention, for example, serum or plasma, can be subjected to various measurements.
Endocrinological tests (including tumor-related tests), such as pituitary function tests, thyroid function tests, pancreatic and digestive tract function tests, adrenal medulla and adrenal cortex function tests, gonad function tests, placental function tests, and parathyroid-related tests Immune component determination test, serum protein-related test, blood glucose control index test, enzyme fraction-related test,
Serum protein component tests such as qualitative and quantitative tests for abnormalities in plasma proteins, antibody tests, antigen tests, hepatitis virus tests, serological tests for infectious diseases, immunoserologic tests such as autoimmune serological tests, immunohematological tests, platelets Function tests, general coagulation tests, coagulation factor tests, coagulation / fibrinolysis tests, etc., immunohematology tests (including blood coagulation tests), protein tests, colloid reaction tests, vital pigment tests, porphyrin-related tests, glucose metabolism Biochemical tests such as tests, lipid tests, nitrogen content tests, clearance tests, electrolyte tests, metal tests, enzyme activity tests, vitamins and other tests (including tests related to industrial medicine such as lead and organic solvents), central nervous system Drug analysis tests for systemic drugs, cardiovascular drugs, antibiotics, narcotics, poisons, etc., congenital abnormal chromosomes, blood disease chromosomes, immune-related genes, leukocyte / malignant lymphoma-related genes, Gene, inspection, such as hereditary disease,
Gene-related tests and HL such as HLA tests and transplantation-related tests
A and cell-mediated immunity tests. These inspections
As measurement, if necessary, for example, edited by Hisashi Tanaka and Setsuo Yokoyama, Development of Pharmaceuticals, Vol. 10, Diagnostics, Hirokawa Shoten, published March 15, 1990; SRL Co., Ltd., General Inspection Guide 1995, April 1995 Mention may be made of various tests listed in Monthly NE, 60,000 NE, the content of which and the content described in the references cited therein are hereby incorporated by reference into the content of this specification.
Reagents, drugs, compounds,
It should be understood that the use of the containers of the present invention for transporting, protecting, storing, etc., substances is also within the scope of the present invention. In accordance with the provisions of the patent statutes, the principles and embodiments of the present invention have been described and illustrated in examples thereof. It should be understood, however, that the invention may be embodied in various forms other than as specifically described and illustrated without departing from the spirit or scope of the appended claims.

[0035]

According to the container of the present invention, objects such as bodily fluids such as blood, serum, plasma and urine, and faeces can be adhered.
The impregnated matrix material, such as filter paper, can be safely and securely retained therein to protect, store, or transport it. Although the container has a very simple structure and can be manufactured easily and inexpensively,
The object can be easily and safely taken out as needed without touching it.

[Brief description of the drawings]

FIG. 1 is a perspective view showing one embodiment of the present invention. In this drawing, all the elements are shown in an expanded state.

FIG. 2 is another perspective view of one of the embodiments of the present invention shown in FIG.

FIG. 3 is a perspective view showing a case where a matrix material such as filter paper is detachably attached to one of the embodiments of the present invention shown in FIG. 2;

FIG. 4 is another perspective view of one of the embodiments of the present invention shown in FIG.

FIG. 5 is another perspective view of one of the embodiments of the present invention shown in FIG. (b) shows the case where a label is attached to the lid.

FIG. 6 is a front view showing one embodiment of the present invention. It is understood that the rear view appears in the front view and the object.

FIG. 7 is a right side view of the specific example shown in FIG. 6; It is understood that the left side view appears to be approximately the subject of the right side view.

8 shows a cross-sectional view of the specific example shown in FIG. 6 (the left side shows the front view direction). In the figure, the leftmost figure is A-
The shape of the A section is shown, the middle figure shows the shape of the BB section, and the rightmost figure shows the shape of the CC section.

9 is a cross-sectional view of the specific example shown in FIG. 6 (the upper side shows the front view direction) and shows the shape of the DD cross section.
The thin line shown in the figure indicates the shape of the background structure.

FIG. 10 is a perspective view showing another embodiment of the present invention.

FIG. 11 is a perspective view showing another embodiment of the present invention.

FIG. 12 is a perspective view showing another embodiment of the present invention.

13 is a view showing a case where a matrix material such as filter paper is detachably attached to the specific example shown in FIG.

Claims (9)

[Claims] An object holding container capable of holding and transporting an object, comprising: (a) an object holding area capable of detachably holding a matrix material capable of holding the object; b) a container bottom capable of accommodating the object holding area; (c) a container lid capable of engaging with the container bottom to cover the object holding area; Is an object holding container obtained by integrally forming a sheet-shaped material. 2. The object holding container according to claim 1, wherein the sheet material is selected from the group consisting of plastic, paper and cloth. 3. The object holding container according to claim 1, wherein the sheet material is paper or cloth processed with a water-repellent material. 4. The object holding region has (i) a projecting region, and (ii) at least a part of the projecting region has an edge of a matrix material capable of holding an object. (Iii) the matrix material holding portion allows the matrix material holding the object to be easily cut out by punching. 2. The object holding container according to claim 1, wherein the hole region is provided as described above, and (iv) the hole region is smaller than the size of the matrix material to be held. 5. The object holding area is: (v) In order to enable the object holding area to be cut out by punching while holding the matrix material holding the object, it is necessary to easily remove the object holding area from the bottom of the container. 2. The object holding container according to claim 1, further comprising a handle so as to make it possible. 6. The container bottom has a convex region, and at least a part of the convex region engages with an edge of the object holding region to detachably hold the object holding region. Further, at least a part of the convex region is engaged with at least a part of the concave region of the container lid,
2. The object holding container according to claim 1, wherein the object holding region covers the object holding region, and makes it possible to shield the matrix material from an external environment. 7. The container lid has a concave area, at least a part of the concave area is engaged with at least a part of the convex area of the container bottom to cover the object holding area, 2. The object holding container according to claim 1, wherein the matrix material can be shielded from an external environment. 8. The method according to claim 1, wherein the structure is selected from the group consisting of the structure shown in FIGS. 1 to 13 and a structure having a function substantially equivalent to the structure shown in FIGS.
An object holding container as described in the above. 9. An object holding container capable of holding and transporting an object, comprising: (a) a matrix material capable of holding the object; and (b) a matrix material capable of detachably holding the matrix material. (C) a container bottom capable of accommodating the object holding area, and (d) a container lid capable of engaging with the container bottom and covering the object holding area. Wherein the object holding container is obtained by integrally forming and processing a sheet-like material.