JPH1112143A - Oral composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To prepare an oral composition having high recalcination activities of a tooth and anticariogenic activities by including a specific sugar-alcohol and regulating the pH so as to be within a specific region. SOLUTION: This oral composition contains one or more kinds of sugar- alcohols selected from xylitol, mannitol, galactitol and inositol, and the pH thereof is regulated so as to be >=8, preferably 8.5-9.5. Bicarbonate of soda is preferably used for regulating the pH so as to be the objective value. Most preferably, the sugar alcohol is xylitol, and the formulating amount of the sugar alcohol is 1-60 wt.%. A compound capable of supplying chloride ion is preferably formulated with the oral composition. The compound for supplying the chloride ion is preferably potassium chloride and sodium chloride. The formulating amount thereof is 0.001-20 wt.% in terms of chloride ion.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to an oral composition having a high remineralizing effect on teeth and a high anticariogenic effect.

[0002]

2. Description of the Related Art
As a sugar alcohol, it has been reported that xylitol exhibits a caries-preventing effect, and an oral preparation containing xylitol (JP-A-51-106741) has been proposed. However, when incorporated into the composition, it is necessary to act several times a day due to poor oral retention in order to exert a sufficient effect. Therefore, there is a demand for the development of a technique that enhances the effect of preventing dental caries with normal use.

[0003]

Means for Solving the Problems and Embodiments of the Invention The present inventors have conducted intensive studies in order to meet the above-mentioned demand, and as a result, have found that a preparation containing a sugar alcohol selected from xylitol, mannitol, galactitol and inositol. p
By setting H to 8 or more, it was found that the anti-caries ability, specifically, the remineralization of the teeth was promoted, and that the effect was significantly enhanced in the presence of chloride ions. It is a thing.

There are many reports on the caries prevention effect of xylitol in academic journals and the like. The effect of xylitol is
The causative bacteria of S. aureus It is generally accepted that the purpose is to suppress the growth of mutans. However, the present inventors have found that the sugar alcohol promotes remineralization of teeth, but not growth inhibition of bacteria.
By adjusting H to 8 or more, the effect could be enhanced.

Hereinafter, the present invention will be described in more detail.
The oral composition of the present invention contains one or more sugar alcohols selected from xylitol, mannitol, galactitol, and inositol, and is adjusted to a pH of 8 or more, whereby remineralization of teeth is prevented. It promotes and suppresses caries.

[0006] The sugar alcohol used in the present invention is one or more selected from xylitol, mannitol, galactitol, and inositol. Xylitol and mannitol are particularly preferred, and xylitol is most preferred. The compounding amount is preferably 1 to 60% (% by weight, hereinafter the same), particularly preferably 5 to 30%. If it is less than 1%, a satisfactory remineralization effect may not be exhibited, and if it exceeds 60%, the feeling of use and taste of the composition may be deteriorated.

The pH of a general composition is in the neutral range, while the pH of the composition of the present invention is 8 or more, and is preferably adjusted to a range of 8.5 to 9.5. To achieve the desired pH, sodium hydroxide, potassium hydroxide, sodium carbonate, sodium hydrogen carbonate, phosphoric acid 2
It can be adjusted with sodium, trisodium phosphate, etc., but it is preferable to have a buffering ability in the pH range of 8.5 to 9.5 in order to maintain the effect in the oral cavity. For these reasons, it is particularly preferable to use baking soda.

In the present invention, the pH can be measured by directly attaching a glass electrode when the oral composition is in the form of a paste or liquid such as toothpaste, mouthwash, mouth freshener and the like.
In the case of chewing gum, 1 g of the chewing gum is added to 10 ml of water.
, Heated at 60 ° C. for 15 minutes, and measured for water after cooling. In the case of a troche, 1 g of
It is a value measured after dissolving in 1.

The oral composition of the present invention preferably contains a compound that supplies chloride ions. As the compound supplying chlorine ions, potassium chloride, sodium chloride, calcium chloride, alkali metal or alkaline earth metal salts such as magnesium chloride and the like are used,
Among them, potassium chloride and calcium chloride are particularly preferred, and potassium chloride is most preferred. The compounding amount is 0.001 to 20%, particularly 0.0
1-10% is preferred. If the amount is less than 0.001%, no effect is obtained, and if it is more than 20%, the feeling of use may deteriorate due to saltiness.

[0010] The oral composition of the present invention includes dentifrices, liquid dentifrices, liquid dentifrices, lubricating dentifrices, powder dentifrices, mouthwashes, mouthwashes, gums and troches. And the like, and most preferably in the form of a dentifrice and further a toothpaste.

The oral composition of the present invention may contain, as other components, abrasives, surfactants, sweeteners, flavors, coloring agents, preservatives, various active ingredients, and the like. In each case, the components conventionally used can be used in a usual dose.

More specifically, silica abrasives such as precipitated silica, silica gel, aluminosilicate, zirconosilicate, etc .;
Hydrates and anhydrides, calcium pyrophosphate, calcium carbonate, aluminum hydroxide, hydroxyapatite,
Examples include alumina, magnesium carbonate, tribasic magnesium phosphate, insoluble sodium metaphosphate, insoluble potassium metaphosphate, titanium oxide, zeolite, aluminum silicate, zirconium silicate, and a synthetic resin-based abrasive.

Examples of the binder include carrageenan, sodium carboxymethylcellulose, cellulose derivatives such as methylcellulose and hydroxyethylcellulose, gums such as xanthan gum, gellan gum, tragacanth gum, karaya gum and gum arabic, polyvinyl alcohol, sodium polyacrylate, carboxyvinyl polymer. And one or more inorganic binders such as silica gel, aluminum silica gel, veegum, and laponite.

As the thickener, sorbit, glycerin, ethylene glycol, propylene glycol, 1,
One or more of 3-butylene glycol, polyethylene glycol, polypropylene glycol and the like may be blended.

As the surfactant, an anionic surfactant, a cationic surfactant, a nonionic surfactant and the like can be blended. Specifically, sodium lauryl sulfate, sodium α-olefin sulfonate, N- Acyl glutamate, 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, N-acyl taurate, sucrose fatty acid ester, alkylol amide, polyoxyethylene hydrogenated castor oil, polyglycerin fatty acid ester, pluronic, Examples thereof include polyoxyethylene sorbitan monostearate.

[0016] Saccharin sodium,
Stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl dihydroxy chalcone, perillartin, etc .; flavors such as l-menthol, carvone, anethole, limonene and other terpenes and derivatives thereof; and coloring agents, blue No. 1 , Yellow 4
And titanium dioxide.

The active ingredients include enzymes such as dextranase, mutanase, lysozyme, amylase, protease, lytic enzyme, superoxide dismutase, tranexamic acid, epsilon aminocaproic acid, aluminum chlorohydroxyallantoin, dihydrocholestanol, glycyrrhizic acid, One or more active ingredients such as glycyrrhetinic acid, bisabolol, isopropylmethylphenol, glycerophosphate, chlorophyll, a water-soluble inorganic phosphate compound, triclosan, cetylpyridinium chloride, and isopropylmethylphenol may be blended.

The amounts of these components can be set as usual within a range not to impair the effects of the present invention.

[0019]

The oral composition of the present invention has a high remineralizing effect on teeth.

[0020]

EXAMPLES The present invention will be described below in detail with reference to Examples and Comparative Examples, but the present invention is not limited to the following Examples. In addition,% in each example shows weight%.

Experimental Example 1 150 mg of hydroxya
Patite powder with Ca: 0.85 mM, PO _Four: 6.
In addition to 200 ml of artificial saliva containing 62 mM, 37 ° C constant temperature
Stir in the water bath. Next, test teeth having the composition shown in Table 1
5 ml of the supernatant obtained by diluting the polish 5 times with distilled water is added.
Ca concentration in the solution 30 minutes, 1 hour and 3 hours after the point
Is measured by atomic absorption spectrophotometry, and the amount of reduced Ca
It was the consumption of Ca due to the chemical conversion. Table 2 shows the results.

[0022]

[Table 1]

[0023]

[Table 2]

The results in Table 1 show the results of Examples 1 and 2 according to the present invention.
Has proven to be effective in remineralizing teeth.

Example 3 Dentifrice (pH: 8.55) Xylitol 5% Sodium hydroxide 0.2 Calcium chloride 0.01 Silicic anhydride 15 Propylene glycol 3 Glycerin (85%) 10 Sorbitol (70%) 10 CMC 1.2 Sodium lauroyl sarcosinate 0.3 Sodium lauryl sulfate 1 Sodium fluoride 0.21 Tranexamic acid 0.05 Saccharin sodium 0.1 Perfume 1.2 Purified water Balance 100%

Example 4 Dentifrice (pH: 8.65) Inositol 5% Baking soda 12 Potassium chloride 0.05 Silicic anhydride 20 Propylene glycol 2 Sorbitol (70%) 30 Xanthan gum 0.8 Carrageenan 0.4 Lauryl sulfate Sodium 1.5 Epsilon aminocaproic acid 0.05 Saccharin sodium 0.2 Perfume 1 Purified water Balance 100%

Example 5 Dentifrice (pH: 8.29) Mannitol 2.5% Sodium hydroxide 0.5 Sodium chloride 15 Silicic anhydride 15 Propylene glycol 3 Glycerin (85%) 23 Xanthan gum 1.2 Lauryl sulfate Sodium 1.2 Dipotassium glycyrrhizinate 0.05 Saccharin sodium 0.1 Fragrance 1.3 Purified water Balance 100%

Example 6 Dentifrice (pH: 8.53) Galactitol 3% Baking soda 10 Calcium chloride 0.05 Silicic anhydride 10 Propylene glycol 5 Glycerin (85%) 15 Sorbitol (70%) 50 CMC 1 Lauroyl Sodium sarcosinate 0.4 Sodium lauryl sulfate 0.5 Triclosan 0.05 Saccharin sodium 0.3 Fragrance 0.6 Purified water Balance 100%

Example 7 Dentifrice (pH: 9.09) Xylitol 2% Sodium hydroxide 0.7 Sodium chloride 0.5 Silicic anhydride 10 Propylene glycol 10 Glycerin (85%) 58 Xanthan gum 0.6 Carrageenan 0 .5 Sodium lauroyl sarcosinate 0.1 Sodium lauryl sulfate 1.2 Sodium fluoride 0.21 Sodium saccharin 0.4 Perfume 1 Purified water Balance 100%

Example 8 Dentifrice (pH: 8.91) Xylitol 20% Baking soda 5 Sodium hydroxide 0.1 Calcium chloride 0.1 Silicic anhydride 15 Propylene glycol 2 Glycerin (85%) 20 CMC 1.2 Carrageenan 0.2 Sodium lauryl sulfate 1.5 Tranexamic acid 0.05 Saccharin sodium 0.2 Perfume 1.2 Purified water Balance 100%

Example 9 Dentifrice (pH: 8.87) Xylitol 5% Sodium hydroxide 0.5 Potassium chloride 0.01 Sodium chloride 18 Dicalcium phosphate 45 Propylene glycol 3 Sorbitol (70%) 30 CMC 5 Sodium lauroyl sarcosinate 0.2 Sodium lauryl sulfate 1 Sodium monofluorophosphate 0.76 Epsilon aminocaproic acid 0.05 Triclosan 0.05 Sodium saccharin 0.3 Fragrance 1 Purified water Balance 100%

Example 10 Dentifrice (pH: 8.62) Inositol 1% Mannitol 1.5 Baking soda 8 Sodium chloride 3 Dicalcium phosphate 40 Propylene glycol 4 Glycerin (85%) 35 Xanthan gum 0.9 Carrageenan 0.3 Sodium lauryl sulfate 1.8 Dipotassium glycyrrhizinate 0.05 Saccharin sodium 0.5 Perfume 0.6 Purified water Balance 100%

Example 11 Dentifrice (pH: 9.11) Xylitol 2% Galactitol 0.5 Sodium hydroxide 0.6 Calcium chloride 0.05 Dicalcium phosphate 35 Propylene glycol 3 Sorbitol (70%) 40 CMC 0.6 Carrageenan 0.8 Sodium lauryl sulfate 2 Sodium monofluorophosphate 0.76 Tranexamic acid 0.05 Epsilon aminocaproic acid 0.05 Saccharin sodium 0.15 Fragrance 0.8 Purified water Balance 100%

Example 12 Dentifrice (pH: 8.83) Xylitol 8% Mannitol 2 Baking soda 10 Sodium chloride 0.8 Dibasic calcium phosphate 45 Propylene glycol 5 Glycerin (85%) 25 Xanthan gum 0.6 Lauroyl sarcosinate Sodium 0.4 Sodium lauryl sulfate 0.5 Saccharin sodium 0.25 Fragrance 1.5 Purified water Balance 100%

Example 13 Dentifrice (pH: 8.51) Galactitol 0.1% Baking soda 0.5 Sodium hydroxide 0.3 Potassium chloride 0.2 Aluminum hydroxide 45 Propylene glycol 2.5 Glycerin (85 %) 25 CMC 1.2 Carrageenan 0.3 Sodium lauroyl sarcosinate 0.1 Sodium lauryl sulfate 1.2 Tranexamic acid 0.05 Triclosan 0.05 Saccharin sodium 0.2 Perfume 1 Purified water Balance 100%

[Example 14] Dentifrice (pH: 9.03) Mannitol 0.5% Sodium hydroxide 0.6 Calcium chloride 0.4 Aluminum hydroxide 40 Propylene glycol 3 Sorbitol (70%) 30 Xanthan gum 0.6 Carrageenan 0.5 Sodium lauryl sulfate 1.5 Saccharin sodium 0.3 Fragrance 1.2 Purified water Balance 100%

Example 15 Dentifrice (pH: 8.51) Xylitol 1% Inositol 1.5 Baking soda 10 Sodium hydroxide 0.1 Sodium chloride 5 Aluminum hydroxide 35 Propylene glycol 5 Sorbitol (70%) 25 CMC 1 .5 Sodium lauryl sulfate 2 Tranexamic acid 0.05 Saccharin sodium 0.25 Fragrance 1.5 Purified water Balance 100%

Example 16 Dentifrice (pH: 8.55) Xylitol 10% Galactitol 0.1 Baking soda 5 Calcium chloride 0.01 Potassium chloride 0.5 Calcium carbonate 40 Propylene glycol 3 Glycerin (85%) 20 CMC 1 Carrageenan 0.6 Sodium lauroyl sarcosinate 0.2 Sodium lauryl sulfate 1.5 Saccharin sodium 0.4 Perfume 1.3 Purified water Balance 100%

[Example 17] Dentifrice (pH: 8.62) Inositol 2% Mannitol 5 Sodium hydroxide 0.2 Calcium chloride 0.2 Sodium chloride 16 Calcium carbonate 35 Silicic anhydride 5 Propylene glycol 4 Sorbitol (70% ) 30 Xanthan gum 1 Carrageenan 0.2 Sodium lauryl sulfate 1.5 Saccharin sodium 0.15 Fragrance 0.8 Purified water Balance 100%

Example 18 Toothpaste (Suspension pH: 9.12) Xylitol 10% Potassium chloride 0.5 Baking soda 10 Calcium carbonate 65 Sorbitol (70%) 2 Glycerin (85%) 8 Saccharin sodium 0.08 Sodium lauryl sulfate 2 Purified water Balance 100%

Example 19 Mouthwash (pH: 8.85) Xylitol 5% Calcium chloride 0.05 Sodium hydroxide 0.1 Ethanol 10 Glycerin (85%) 8 Saccharin sodium 0.1 Polyoxyethylene hydrogenated castor oil 1 Sodium benzoate 0.3 Perfume 0.5 Purified water Balance 100%

Example 20 Mouthwash (pH: 9.12) Xylitol 2% Sodium chloride 5 Baking soda 5 Ethanol 5 Sorbitol (70%) 10 Saccharin sodium 0.1 Pluronic F127 2 Sodium benzoate 0.3 Perfume 0 4 Purified water balance 100%

Example 21 Mouthwash (pH: 8.56) Mannitol 5% Potassium chloride 0.03 Baking soda 8 Allantoin 0.5 Ethanol 8 Glycerin (85%) 12 Saccharin sodium 0.1 Polyoxyethylene hydrogenated castor oil 1.2 Sodium benzoate 0.3 Perfume 0.5 Purified water Balance 100%

Example 22 Mouth Freshener (pH: 8.67) Xylitol 3% Sodium hydroxide 0.3 Ethanol 30 Glycerin (85%) 15 Saccharin sodium 0.3 Polyoxyethylene hydrogenated castor oil 3 Perfume 1 Purified water 100% remaining

Claims (2)

[Claims] 1. An oral composition comprising one or more sugar alcohols selected from xylitol, mannitol, galactitol and inositol, and adjusted to a pH of 8 or more. 2. The oral composition according to claim 1, wherein the composition for supplying chlorine ions contains 0.001% by weight or more of chloride ions.