JPH1033511A - Non-invasion biological measuring instrument - Google Patents

Abstract

PROBLEM TO BE SOLVED: To improve accuracy for measurement by installing a light source, for which a semiconductor laser or an LED is used, at a rotary structural body and bringing it into light contact with a living body. SOLUTION: The rotary structural body is composed of a short diameter side rotary structural body 1 to be inserted into an earhole and a long diameter side rotary structural body 2 to be functioned as a stopper for preventing this structural body 1 from being inserted into the earhole too much. The short diameter side rotary structural body 1 is composed of a substrate section 15 for installing a photodetector 4 and a transparent body section 16 made of such as acrylic resin for protecting the photodetector 4. A light source 3 is installed on the plane of the long diameter side rotary structural body 3 on the side of the earhole vertically to its rotary axis. The light source 3 and the photodetector 4 and be installed while reversing their positions as well. The cross sections of the light source 3 and the photodetector 4 can be made elliptical as well. Since the light source 3 is tightly adhered to the ear and the photodetector 4 is located inside the earhole, high-accuracy measurement is enabled without being affected by the external ambient temperature or stray light.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a biochemical analyzer for medical use, and more particularly to an apparatus for non-invasively measuring glucose concentration in blood.

[0002]

2. Description of the Related Art An apparatus for measuring biological information using near-infrared light is disclosed in Japanese Unexamined Patent Publication No. 3-173535, "Non-invasive glucose measuring method".
It is described in. In the above prior art, the absorption wavelength band by glucose is set to 1600 to 1750 nm, and the reference wavelength band not by glucose is set to 1200 to 1300 nm, and both near-infrared lights are irradiated on the living tissue to calculate the difference between both transmitted energies. This is a method for determining the glucose concentration in the living tissue. In this method, a part of light emitted from a light source is directly reflected, and another part is reflected by a concave reflecting mirror to irradiate a living tissue, and the transmitted light is detected by a PbS sensor.

[0003]

SUMMARY OF THE INVENTION In an apparatus for directly irradiating near-infrared light to a living body, detecting the intensity of transmitted and diffused light, and measuring biological components based on the detection result, a semiconductor laser is used as a light source. Alternatively, when an LED is used, the light output is not stable due to an influence based on a change in the outside air temperature. For this reason, the light emitted from the light source is applied to the living body, and an error occurs in the intensity of the obtained transmitted and diffused light. Further, when the photodetector is exposed to the outside, an error due to the influence of stray light on the photodetector has occurred. The above prior art does not disclose a device for stabilizing a change in light output due to a change in outside air temperature of the light source. Further, there is no disclosure of a device for preventing stray light from entering a detector that detects light transmitted and scattered by irradiating a living body.

An object of the present invention is to provide a high-precision noninvasive biochemical measurement apparatus by installing a light source and a photodetector on a rotating structure to eliminate measurement errors due to changes in outside air temperature and the effects of stray light. It is to be.

[0005]

The object of the present invention is to use a semiconductor laser or an LED as a light source, install the light source on a rotating structure, and bring the light source into close contact with a living body, thereby obtaining a measurement error based on the influence of a change in the outside air temperature. And eliminate the measurement error based on the influence of stray light by installing the photodetector on the rotating structure and inserting it into the hole of the ear of the living body to keep the photodetector in a dark room. Achieves highly accurate measurement.

[0006]

DESCRIPTION OF THE PREFERRED EMBODIMENTS The near-infrared region is between the fundamental sound spectrum of molecular vibration (middle infrared) and the electronic spectrum of atoms and molecules (visible and ultraviolet), and is a wavelength region which is originally transparent. The spectrum of the overtones, harmonics and combined sounds of the movement appears. Therefore, near-infrared light can be used for qualitative and quantitative analysis of a specific molecule. The near-infrared region has relatively high biological permeability and is suitable for non-invasively acquiring information in a living body.

When a living body is irradiated with near-infrared light, a part of the light is reflected on the surface, and the other part is diffused and transmitted through the living body. At that time, part of the near-infrared light is absorbed by the biological material. Incident light intensity I0
Lambert-Be expressed by Equation 1 between the transmitted light intensity It and
It is thought that er's law holds.

[0008]

## EQU1 ## where c is the concentration of the absorbing substance, k is the extinction coefficient, and d is the thickness of the absorbing substance.

Thus, if the thickness of the sample is kept constant by using a laser adjusted to the absorption wavelength of the target substance, the concentration of the target substance can be determined by measuring the transmitted light intensity. For example, the glucose concentration in blood serves as an indicator of diabetes and is an important test item in clinical tests. Glucose is 1560
Since it has characteristic absorption at nm, 2076 nm, and 2272 nm, the concentration of glucose in a living body and mainly in blood can be quantified without collecting blood by using a semiconductor laser and a photodetector having any of the above wavelengths. . Since light is greatly scattered in a living body, it is necessary to use a high-power laser for measuring a thick biological sample. For example, when a semiconductor laser having a wavelength of 1560 nm and an output of 10 mW is used, a living body having a thickness of about 1.5 mm can be measured, and a laser having a wavelength of 100 mW can be used to measure a living body having a thickness of about 8 mm. .

An example in which a semiconductor laser or LED having such a characteristic of near-infrared light is applied to noninvasive biochemical measurement will be described.

FIG. 1 shows a first embodiment of the present invention. This is an earphone type non-invasive biochemical measurement device. FIG. 1 (a)
1 is an overall view of the present embodiment, and FIGS. 1B and 1C are enlarged views of a signal detection block including a light source 3 and a photodetector 4. FIG.

The overall configuration of the present embodiment will be described with reference to FIG. The light source 3 made of a semiconductor laser or an LED is driven by the light source drive current supply device 5, and the light emitted from the light source 3 is applied to the living body (ear) 13. The transmitted and diffused light is detected by a photodetector 4 composed of a light receiving element or the like for converting the light into an electric signal, amplified by an amplifying unit 6, and sent to a biological signal arithmetic processing unit 7 composed of a computer. Sent.
The biological signal arithmetic processing unit 7 converts the data into absorbance, transmission characteristics, and the like by arithmetic processing, displays the arithmetic result on the display device 10, and records the arithmetic result in the storage device 11.

In this embodiment, a light source 3, a signal detection block which makes the photodetector 4 small and made into one block, a light source drive current supply device 5, an amplifying unit 6, a biological signal operation processing device 7,
The control unit 8, the display device 10, and the storage device 11 are reduced in size and the arithmetic processing block 14 housed in one block is separated.
The space between them is connected by a flexible signal line. By separating the signal detection block and the arithmetic processing block 14, the biological signal of the subject can be continuously measured non-invasively without restraining the time of the subject, and by reducing the size, Be portable.

The signal detection block including the light source 3 and the photodetector 4 will be described in detail with reference to FIGS. 1B and 1C. FIG. 1B is a sectional view of the small-diameter-side rotating structure 1 taken along a section 17, and FIG. 1C is a perspective view of the entire detection block. The small-diameter side rotating structure 1 is a portion inserted into the ear hole, and the large-diameter side rotating structure 2 is a portion serving as a stopper so as not to excessively enter the ear hole. The small-diameter-side rotating structure 1 includes a light source 3
And a transparent portion 16 made of acrylic or glass material. The transparent portion 16 has a role of transmitting light and protecting the photodetector 4. The light source 3 and the photodetector 4 are installed as shown in FIG. The light source 3 is installed on the surface of the ear hole side perpendicular to the rotation axis of the large-diameter rotating structure 2, and the photodetector 4 is installed on the substrate 15 of the small-diameter rotating structure 1. Conversely, the light source 3 and the light detector 4 may be installed on the small-diameter rotating structure 1 and the light detector 4 may be installed on the large-diameter rotating structure 2. Needless to say, the rotating structure on which the light source 3 and the photodetector 4 are installed may be a structure having an elliptical cross section. Since the light source 3 is in close contact with the ear and the light detector 4 is located in the ear hole, high-precision measurement can be performed without being affected by the outside air temperature and the influence of stray light. Further, since the light passes through the transparent body 16 before entering the photodetector 4, high-precision measurement can be performed by performing an operation in consideration of the transmittance and the reflectance of the transparent body 16.

FIGS. 2 to 9 show second to ninth embodiments of the present invention. Each of the drawings shows a signal detection block unit including the light source 3 and the photodetector 4 of the earphone type noninvasive biochemical measurement device shown in the first embodiment. In each figure,
(A) is a sectional view of the small-diameter-side rotating structure 1 taken along a section 17, and (b) is a perspective view showing the entire detection block.

The signal detection block including the light source 3 and the photodetector 4 will be described in detail with reference to FIG. This embodiment is an example in which a plurality of photodetectors 4 are used. Small-diameter rotating structure 1
Is a portion to be inserted into the ear hole, and the large-diameter-side rotating structure 2 is a portion serving as a stopper so as not to excessively enter the ear hole. The small-diameter-side rotating structure 1 includes a substrate portion 15 on which the light source 3 is installed, and a transparent portion 1 made of acrylic or glass material.
The transparent body portion 16 plays a role of transmitting light and protecting the photodetector 4. The light source 3 and the light detector 4 are shown in FIG.
Install as shown. The light source 3 is installed on the surface of the ear hole side perpendicular to the rotation axis of the large-diameter rotating structure 2, and the photodetector 4 is installed on the substrate 15 of the small-diameter rotating structure 1. The photodetector 4 uses a plurality of detectors having the same characteristics, detects the light emitted from the light source 3 efficiently, and improves the S / N ratio. Conversely, the light source 3 and the light detector 4 may be installed on the small-diameter rotating structure 1 and the light detector 4 may be installed on the large-diameter rotating structure 2. Needless to say, the rotating structure on which the light source 3 and the photodetector 4 are installed may be a structure having an elliptical cross section. Since the light source 3 is in close contact with the ear and the light detector 4 is located in the ear hole, high-precision measurement can be performed without being affected by the outside air temperature and the influence of stray light. In addition, light is emitted from the photodetector 4.
Since the light passes through the transparent body 16 before being incident on the
By performing the calculation in consideration of the transmittance and the reflectance of the object, highly accurate measurement can be performed.

FIG. 3 shows a third embodiment of the present invention. In the signal detection block of the earphone type non-invasive biochemical measurement device shown in the first embodiment, the light source 3 and the photodetector 4
Is an example of using a plurality of.

The signal detection block including the light source 3 and the photodetector 4 will be described in detail with reference to FIG. The small-diameter side rotating structure 1 is a portion inserted into the ear hole, and the large-diameter side rotating structure 2 is a portion serving as a stopper so as not to excessively enter the ear hole. The small-diameter rotating structure 1 is composed of a substrate portion 15 on which the light source 3 is installed, and a transparent portion 16 made of acrylic or glass material. The transparent portion 16 protects light transmission and protection of the photodetector 4. Take a role. The light source 3 and the light detector 4 are installed as shown in FIG. The light source 3 is installed on the surface of the ear hole side perpendicular to the rotation axis of the large-diameter rotating structure 2, and the photodetector 4 is installed on the substrate 15 of the small-diameter rotating structure 1. The light source 3 uses a plurality of light sources 3 and photodetectors 4 having the same characteristics to increase the light intensity and the photodetector 4 to detect a weak signal efficiently, thereby improving the S / N ratio. Make it possible. On the contrary, the light source 3 and the photodetector 4 convert the light source 3 into the small-diameter-side rotating structure 1,
The photodetector 4 may be installed on the large-diameter rotary structure 2. Needless to say, the rotating structure on which the light source 3 and the photodetector 4 are installed may be a structure having an elliptical cross section. Since the light source 3 is in close contact with the ear and the light detector 4 is located in the ear hole, high-precision measurement can be performed without being affected by the outside air temperature and the influence of stray light. Further, since the light passes through the transparent body 16 before entering the photodetector 4, high-precision measurement can be performed by performing an operation in consideration of the transmittance and the reflectance of the transparent body 16.

FIG. 4 shows a fourth embodiment of the present invention. This is another example in which a plurality of photodetectors 4 are used.

The signal detection block including the light source 3 and the photodetector 4 will be described in detail with reference to FIG. The small-diameter side rotating structure 1 is a portion inserted into the ear hole, and the large-diameter side rotating structure 2 is a portion serving as a stopper so as not to excessively enter the ear hole. The small-diameter rotating structure 1 is composed of a substrate portion 15 on which the light source 3 is installed, and a transparent portion 16 made of acrylic or glass material. The transparent portion 16 protects light transmission and protection of the photodetector 4. Take a role. The light source 3 and the light detector 4 are installed as shown in FIG.

The light source 3 is installed on the surface of the ear hole side perpendicular to the rotation axis of the large-diameter rotary structure 2, and the photodetector 4 is installed on the substrate 15 of the small-diameter rotary structure 1. The photodetector 4 is provided with a plurality of detectors having the same characteristics on the same circumference centered on the light emission point of the light source 3, detects light emitted from the light source 3 efficiently, and increases the S / N ratio. Enables improvement. Conversely, the light source 3 and the light detector 4 may be installed on the small-diameter rotating structure 1 and the light detector 4 may be installed on the large-diameter rotating structure 2. Needless to say, the rotating structure on which the light source 3 and the photodetector 4 are installed may be a structure having an elliptical cross section. Light source 3
Is in close contact with the ear and the photodetector 4 is in the hole in the ear,
High-precision measurement is possible without being affected by the outside air temperature and the influence of stray light. Further, since the light passes through the transparent body 16 before entering the photodetector 4, high-precision measurement can be performed by performing an operation in consideration of the transmittance and the reflectance of the transparent body 16.

FIG. 5 shows a fifth embodiment of the present invention. This is another example in which a plurality of light sources 3 and photodetectors 4 are used.

The signal detection block including the light source 3 and the photodetector 4 will be described in detail with reference to FIG. The small-diameter side rotating structure 1 is a portion inserted into the ear hole, and the large-diameter side rotating structure 2 is a portion serving as a stopper so as not to excessively enter the ear hole. The small-diameter rotating structure 1 is composed of a substrate portion 15 on which the light source 3 is installed, and a transparent portion 16 made of acrylic or glass material. The transparent portion 16 protects light transmission and protection of the photodetector 4. Take a role. The light source 3 and the light detector 4 are installed as shown in FIG.

The light source 3 is installed on the surface of the ear hole side perpendicular to the rotation axis of the large-diameter rotating structure 2, and the photodetector 4 is installed on the substrate 15 of the small-diameter rotating structure 1. As shown in FIG. 5, a plurality of photodetectors 4 having the same characteristics are arranged on the same circumference around the light emission point of the corresponding light source 3 as shown in FIG. The light source 3 uses a plurality of light sources 3 and photodetectors 4 having the same characteristics to increase the light intensity and the photodetector 4 to detect a weak signal efficiently, thereby improving the S / N ratio. Make it possible.
Conversely, the light source 3 and the light detector 4 may be installed on the small-diameter rotating structure 1 and the light detector 4 may be installed on the large-diameter rotating structure 2. Needless to say, the rotating structure on which the light source 3 and the photodetector 4 are installed may be a structure having an elliptical cross section. Since the light source 3 is in close contact with the ear and the light detector 4 is located in the ear hole, high-precision measurement can be performed without being affected by the outside air temperature and the influence of stray light. In addition, light is emitted from the photodetector 4.
Since the light passes through the transparent body 16 before being incident on the
By performing the calculation in consideration of the transmittance and the reflectance of the object, highly accurate measurement can be performed.

FIG. 6 shows a sixth embodiment of the present invention. This is an example in which the arrangement of the light source 3 and the photodetector 4 is changed.

The signal detection block including the light source 3 and the photodetector 4 will be described in detail with reference to FIG. The small-diameter side rotating structure 1 is a portion inserted into the ear hole, and the large-diameter side rotating structure 2 is a portion serving as a stopper so as not to excessively enter the ear hole. The small-diameter rotating structure 1 is composed of a substrate portion 15 on which the light source 3 and the photodetector 4 are installed, and a transparent portion 16 made of acrylic or glass material.
Plays a role of transmitting light and protecting the light source 3 and the photodetector 4. In the present embodiment, one light source 3 and one light detector 4 are provided on the substrate 15 of the small-diameter-side rotating structure 1, respectively.
Conversely, the light source 3 and the photodetector 4 may be installed on the surface of the ear hole side perpendicular to the rotation axis of the large-diameter-side rotating structure 2. Needless to say, the rotating structure on which the light source 3 and the photodetector 4 are installed may be a structure having an elliptical cross section.

Light emitted from the light source 3 is applied to the living body (ear) 1.
The light is reflected by 3 and detected by the photodetector 4. Since the large-diameter-side rotating structure 2 is in close contact with the ear and the light source 3 and the photodetector 4 are located in the ear holes, high-precision measurement can be performed without being affected by the outside air temperature and stray light. In addition, light is emitted from the photodetector 4.
Since the light passes through the transparent body 16 before being incident on the
By performing the calculation in consideration of the transmittance and the reflectance of the object, highly accurate measurement can be performed.

FIG. 7 shows a seventh embodiment of the present invention. The arrangement of the light source 3 and the photodetector 4 is changed, and the light source 3 and the photodetector 4 are changed.
Is an example of using a plurality of.

The signal detection block including the light source 3 and the photodetector 4 will be described in detail with reference to FIG. The small-diameter side rotating structure 1 is a portion inserted into the ear hole, and the large-diameter side rotating structure 2 is a portion serving as a stopper so as not to excessively enter the ear hole. The small-diameter rotating structure 1 is composed of a substrate portion 15 on which the light source 3 and the photodetector 4 are installed, and a transparent portion 16 made of acrylic or glass material.
Plays a role of transmitting light and protecting the light source 3 and the photodetector 4. FIG. 7 shows an example in which one light source 3 is disposed at the center and four photodetectors 4 having the same characteristics are arranged around the light source 3. In this embodiment, a plurality of light sources 3 and photodetectors 4 having the same characteristics are used. The light source 3 is used to increase the light intensity and the light detector 4
Uses a plurality of light sources 3 and photodetectors 4 having the same characteristics in order to efficiently detect a weak signal, thereby improving the S / N ratio. Conversely, the light source 3 and the photodetector 4 may be installed on the surface of the ear hole side perpendicular to the rotation axis of the large-diameter-side rotating structure 2. Needless to say, the rotating structure on which the light source 3 and the photodetector 4 are installed may be a structure having an elliptical cross section.

Light emitted from the light source 3 is applied to the living body (ear) 1.
The light is reflected by 3 and detected by the photodetector 4. Since the large-diameter-side rotating structure 2 is in close contact with the ear and the light source 3 and the photodetector 4 are located in the ear holes, high-precision measurement can be performed without being affected by the outside air temperature and stray light. In addition, light is emitted from the photodetector 4.
Since the light passes through the transparent body 16 before being incident on the
By performing the calculation in consideration of the transmittance and the reflectance of the object, highly accurate measurement can be performed.

FIG. 8 shows an eighth embodiment of the present invention. This is an example in which the arrangement of the light source 3 and the photodetector 4 is changed.

The signal detection block including the light source 3 and the photodetector 4 will be described in detail with reference to FIG. The small-diameter side rotating structure 1 is a portion inserted into the ear hole, and the large-diameter side rotating structure 2 is a portion serving as a stopper so as not to excessively enter the ear hole. The small-diameter rotating structure 1 is composed of a substrate portion 15 on which the light source 3 and the photodetector 4 are installed, and a transparent portion 16 made of acrylic or glass material.
Plays a role of transmitting light and protecting the light source 3 and the photodetector 4. In the present embodiment, one light source 3 and one light detector 4 are provided on the substrate 15 of the small-diameter-side rotating structure 1, respectively.

The light emitted from the light source 3 is applied to the living body (ear) 1
The light is reflected by 3 and detected by the photodetector 4. It is assumed that the light emitted from the light source 3 is reflected from a point such as a blood vessel of a living body (ear), and the light source 3 and the photodetector 4 are arranged on the same circumference centering on a certain reflection point of the light. I do. Conversely, the light source 3 and the photodetector 4 may be installed on the surface of the ear hole side perpendicular to the rotation axis of the large-diameter-side rotating structure 2. Needless to say, the rotating structure on which the light source 3 and the photodetector 4 are installed may be a structure having an elliptical cross section. Since the light source 3 is in close contact with the ear and the light detector 4 is located in the ear hole, high-precision measurement can be performed without being affected by the outside air temperature and the influence of stray light. Further, since the light passes through the transparent body 16 before entering the photodetector 4, high-precision measurement can be performed by performing an operation in consideration of the transmittance and the reflectance of the transparent body 16.

FIG. 9 shows a ninth embodiment of the present invention. This is an example in which the arrangement of the light source 3 and the photodetector 4 is changed and a plurality of the light sources 3 and the photodetectors 4 are used.

The signal detection block including the light source 3 and the photodetector 4 will be described in detail with reference to FIG. The small-diameter side rotating structure 1 is a portion inserted into the ear hole, and the large-diameter side rotating structure 2 is a portion serving as a stopper so as not to excessively enter the ear hole. The small-diameter rotating structure 1 is composed of a substrate portion 15 on which the light source 3 and the photodetector 4 are installed, and a transparent portion 16 made of acrylic or glass material.
Plays a role of transmitting light and protecting the light source 3 and the photodetector 4. FIG. 9 shows an example in which one light source 3 is arranged at the center and four photodetectors 4 having the same characteristics are arranged around the light source 3.

Light emitted from the light source 3 is applied to the living body (ear) 1
The light is reflected by 3 and detected by the photodetector 4. It is assumed that the light emitted from the light source 3 is reflected from a point such as a blood vessel of a living body (ear), and the light source 3 and the photodetector 4 are arranged on the same circumference centering on a certain reflection point of the light. I do. In this embodiment, a plurality of light sources 3 and photodetectors 4 having the same characteristics are used. The light source 3 uses a plurality of light sources 3 and photodetectors 4 having the same characteristics to increase the light intensity and the photodetector 4 to detect a weak signal efficiently, thereby improving the S / N ratio. Make it possible. Conversely, the light source 3 and the photodetector 4 may be installed on the surface of the ear hole side perpendicular to the rotation axis of the large-diameter-side rotating structure 2. Needless to say, the rotating structure on which the light source 3 and the photodetector 4 are installed may be a structure having an elliptical cross section. Since the large-diameter-side rotating structure 2 is in close contact with the ear and the light source 3 and the photodetector 4 are located in the ear holes, high-precision measurement can be performed without being affected by the outside air temperature and stray light. Further, since the light passes through the transparent body 16 before entering the photodetector 4, high-precision measurement can be performed by performing an operation in consideration of the transmittance and the reflectance of the transparent body 16.

FIG. 10 shows a tenth embodiment of the present invention.
This is a non-invasive biochemical measurement device with built-in speaker. FIG. 10A is an overall view of the present embodiment, and FIGS.
(c) is an enlarged view of a signal detection block including the light source 3, the photodetector 4, and the speaker 12.

The overall configuration of the present embodiment will be described with reference to FIG. Light source 3 composed of semiconductor laser or LED
Is driven by the light source drive current supply device 5 to irradiate the light emitted from the light source 3 to the living body (ear) 13. The transmitted and diffused light is detected by a photodetector 4 composed of a light receiving element or the like for converting the light into an electric signal, amplified by an amplifying unit 6, and sent to a biological signal arithmetic processing unit 7 composed of a computer. Sent. The biological signal arithmetic processing unit 7 converts the data into absorbance, transmission characteristics, and the like by arithmetic processing, and displays the arithmetic result on the display device 10.
, Recorded in the storage device 11, and the audio processing circuit 9
Through the speaker 12 to the user. In this embodiment, a light source 3, a photodetector 4, a signal detection block which makes the speaker 12 small and forms one block, a light source driving current supply device 5, an amplifying unit 6, a biological signal arithmetic processing unit 7, a control unit 8, The audio processing circuit 9, the display device 10, and the storage device 11 are miniaturized to separate operation processing blocks housed in one block, and these are connected by flexible signal lines. By separating the signal detection block and the arithmetic processing block 14, without binding the time of the subject,
The patient's biological signals can be continuously measured non-invasively,
In addition, it is made portable by making it compact.

The signal detection block including the light source 3 and the photodetector 4 will be described in detail with reference to FIGS. 1B is a cross-sectional view of the small-diameter rotary structure 1 taken along a cross section 17, and FIG. 1C is a perspective view of a detection block. The small-diameter side rotating structure 1 is a portion inserted into the ear hole, and the large-diameter side rotating structure 2 is a portion serving as a stopper so as not to excessively enter the ear hole. The small diameter side rotating structure 1 is
It is composed of a substrate portion 15 on which the light source 3 is installed and a transparent portion 16 made of acrylic or glass material. The transparent portion 16 plays a role of transmitting light and protecting the photodetector 4.

The light source 3 and the light detector 4 are shown in FIG.
Install as shown in (c). The light source 3 is installed on the surface of the ear hole side perpendicular to the rotation axis of the large-diameter rotating structure 2, and the photodetector 4 is installed on the substrate 15 of the small-diameter rotating structure 1. Conversely, the light source 3 and the light detector 4 may be installed on the small-diameter rotating structure 1 and the light detector 4 may be installed on the large-diameter rotating structure 2. Needless to say, the rotating structure on which the light source 3 and the photodetector 4 are installed may be a structure having an elliptical cross section. The speaker 12 is built in the substrate 15. The speaker 12 is desirably installed on the side near the back of the ear hole. In the present embodiment, a speaker 12 built in the small-diameter-side rotating structure 1 provides a user with the use procedure of the present apparatus and measurement results such as absorbance and transmission characteristics converted by the arithmetic processing in the biological signal arithmetic processing unit 7 to the user. It has a function to guide. The method of guiding the measurement result to the user is, for example, when guiding the blood glucose level, a method of directly guiding the blood glucose level by voice, or comparing the blood glucose level with a normal blood glucose level range using the pulse sound and the previously measured blood glucose level. When the blood sugar level increases, the interval between the pulse sounds is increased, and when the blood sugar level decreases, the interval between the pulse sounds is decreased. The speaker 12 built in the rotating structure 1
By guiding the user to the measurement procedure and the measurement result, the user can use the device simply and conveniently. Light source 3
Is in close contact with the ear and the photodetector 4 is in the hole in the ear,
High-precision measurement is possible without being affected by the outside air temperature and the influence of stray light. Further, since the light passes through the transparent body 16 before entering the photodetector 4, high-precision measurement can be performed by performing an operation in consideration of the transmittance and the reflectance of the transparent body 16.

[0041]

According to the present invention, measurement errors due to the influence of the outside air temperature and the influence of stray light can be eliminated, and highly accurate measurement can be performed. In addition, it is possible to provide a noninvasive biochemical measurement device that can be used simply and conveniently by guiding the user to measurement procedures and measurement results.

[Brief description of the drawings]

FIG. 1 is a schematic diagram showing an earphone-type noninvasive biochemical measurement device according to one embodiment of the present invention.

FIG. 2 is a cross-sectional view and a perspective view of an earphone-type signal detection block used in the embodiment of the present invention.

FIG. 3 is a cross-sectional view and a perspective view of an earphone-type signal detection block unit used in the embodiment of the present invention.

FIG. 4 is a cross-sectional view and a perspective view of an earphone-type signal detection block unit used in the embodiment of the present invention.

FIG. 5 is a cross-sectional view and a perspective view of an earphone-type signal detection block unit used in the embodiment of the present invention.

FIG. 6 is a cross-sectional view and a perspective view of an earphone-type signal detection block unit used in the embodiment of the present invention.

FIG. 7 is a cross-sectional view and a perspective view of an earphone-type signal detection block unit used in the embodiment of the present invention.

FIG. 8 is a cross-sectional view and a perspective view of an earphone-type signal detection block unit used in the embodiment of the present invention.

FIG. 9 is a cross-sectional view and a perspective view of an earphone-type signal detection block unit used in the embodiment of the present invention.

FIG. 10 is a schematic diagram showing an earphone-type noninvasive biochemical measurement device according to one embodiment of the present invention.

[Explanation of symbols]

1 ... rotating structure (small diameter side), 2 ... rotating structure (large diameter side), 3 ... light source (semiconductor laser or LED), 4 ...
Photodetector, 5 ... Light source drive current supply device, 6 ... Amplifier, 7
... biological signal arithmetic processing device, 8 ... control unit, 9 ... audio processing device, 10 ... display device, 11 ... storage device, 12 ... speaker, 13 ... biological body (ear), 14 ... arithmetic processing block, 15
... substrate, 16 ... transparent body (acrylic, glass, etc.).

 ──────────────────────────────────────────────────続 き Continued on the front page (72) Inventor Tomoharu Kajiyama 1-280 Higashi Koigakubo, Kokubunji-shi, Tokyo Inside Central Research Laboratory, Hitachi, Ltd.

Claims (7)

[Claims] A living body is directly illuminated with light emitted from a light source, and the intensity of transmitted, diffused and reflected light is detected by a photodetector, and the detection is performed. Based on the results, it is a device for measuring biological components, using a semiconductor laser or LED as a light source, a rotating structure having a structure in which two rotating structures having different diameters are connected to the rotating axis equally, a light source and a photodetector. A non-invasive biochemical measurement device characterized by installing a. 2. A rotating structure having a structure in which two rotating structures having different diameters, in which the light source and the photodetector according to claim 1 are installed, are arranged so that their rotation axes are equal. A non-invasive biochemical measurement device which is inserted into an ear hole and is used by being attached to a biological ear using a large diameter side of a rotating structure as a stopper. 3. The light source according to claim 1, which is mounted on a plane perpendicular to the rotation axis on the large diameter side of the rotating structure, and the photodetector is mounted on a plane parallel to the rotation axis on the small diameter side of the rotating structure. Inversely, the light source is installed on a plane parallel to the rotation axis on the small diameter side of the rotating structure, and the photodetector is installed on a surface perpendicular to the rotation axis on the large diameter side of the rotating structure. Biochemical measurement device. 4. A non-invasive biochemical measurement apparatus, wherein the light source and the photodetector according to claim 1 are installed on a plane parallel to a rotation axis on a smaller diameter side of the rotating structure. 5. A non-invasive biochemical measurement apparatus according to claim 1, wherein the light source and the photodetector according to claim 1 are each provided with a plurality of light sources and photodetectors having the same characteristics. 6. A method for installing a plurality of light sources and light detectors according to claim 5, wherein the plurality of light detectors are installed on the same circumference centering on the light emission point of one light source. A non-invasive biochemical measurement device, characterized in that: 7. The non-invasive biochemical measurement apparatus according to claim 1, wherein the rotating structure has a built-in speaker and a mechanism for guiding a measurement procedure and a measurement result to a user.