JPH10226615A - Composition containing aspartic acid-phenylalanine cyclic dipeptide derivative - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject cyclic dipeptide-containing composition that can improve stability of medicines, cosmetics, food products and the like, particularly their stability at a temperature near the body temperature by admixing a specific compound to these products. SOLUTION: 1,3,5-Benzenetricarboxylic acid having the stereostructure responding to the compound to be prepared is allowed to react with thionyl chloride and the resultant acid chloride is allowed to react with the corresponding alkylamine or alkenylamine, and the product is purified, when necessary, to form an aspartic acid-phenylalanine cyclic dipeptide derivative of formula I [R is a 8-22C (cyclic structure-including) straight or branched alkyl or alkenyl] typically cyclo(L-β-dimethyloctylasparaginyl-L-phenylalanine). This compound is admixed to cosmetics, medicines and the like, particularly of high content of oily components. The amount of the compound of formula I is preferably 0.1-100 pts.wt. per 1 pt.wt. of the oily component.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to a composition containing a phenylalanine aspartate cyclic dipeptide derivative suitable for thickening and gelling a fluid organic substance such as oil.

[0002]

2. Description of the Related Art In the fields of cosmetics, pharmaceuticals, foods and the like, increasing the viscosity and hardness of these preparations has been very important in terms of ensuring stability. As means for increasing the hardness or viscosity, there are a method using a thickener and a method using a wax structure such as wax. However, only water-soluble thickeners such as alkyl acrylate copolymers are known, and it has been difficult to apply them to oil gel systems such as suppositories and lip colors. In the method using the structure of the wax, the structure of the wax is weak against the temperature, so the amount of the wax is too large to improve the stability in the body temperature region around 40 ° C. In many cases, the usability was impaired because of unevenness, pain when inserted into the anus, etc., and severe foreign body sensation. Also, 12-hydroxystearic acid is known as a gelling agent for an organic component, but it can provide only a state of forming a gel or becoming a solution, and it is difficult to control viscosity. there were. That is, there has been a demand for means for stabilizing the system at a temperature near body temperature without impairing usability.

On the other hand, compounds represented by the following general formula (I) are known compounds, and it has been known that these compounds exert a gelling effect on organic substances having fluidity. It is not known at all that the stability can be improved by incorporating it into cosmetics or medicines.

[0004]

DISCLOSURE OF THE INVENTION The present invention has been made under such a circumstance, and is intended to provide a composition for pharmaceuticals, cosmetics, foods and the like which has excellent stability especially at a high temperature of about 40 ° C. The task is to provide.

[0005]

In view of such circumstances, the present inventors have studied the stability of a composition containing an oily component such as a cosmetic or a medicine at a temperature near body temperature (around 40 ° C.). As a result of intensive studies in search of means for improving the usability without impairing usability, it has been found that the compounds represented by the following general formula (I) have such properties. Furthermore, it has been found that the stability of the composition at a temperature near the body temperature is improved by blending it with a composition such as a medicine, cosmetics, and food. As a result of further studies, they have found that there is little change in viscosity with respect to temperature and that use of such a composition at 5 to 10 ° C. does not impair the usability, and has completed the invention. Hereinafter, the present invention will be described in detail focusing on embodiments of the invention.

[0006]

Embedded image General formula (I) (where R represents a linear or branched alkyl group or alkenyl group that can have a cyclic structure having 8 to 22 carbon atoms)

[0007]

BEST MODE FOR CARRYING OUT THE INVENTION

(1) Compound represented by the general formula (I) contained in the composition of the present invention The compound contained in the composition of the present invention is represented by the above general formula (I)
Has a structure represented by Among these, a particularly preferred one is one in which the cyclic portion represented by the general formula (II) has an L, L steric structure. Preferred examples of such a compound include, for example, cyclo (L-β-dimethyloctylasparaginyl-L-phenylalanyl) (compound 1), cyclo (L-β-laurylasparaginyl-L-phenylarayl) Nil) (compound 2), cyclo (L-β-stearylasparaginyl-L-phenylalanyl) (compound 3), cyclo (L-β-oleylasparaginyl-L-
Phenylalanyl) (compound 4), cyclo (L-β-
Isooctyl asparaginyl-L-phenylalanyl)
(Compound 5) or cyclo (L-β-cyclohexylasparaginyl-L-phenylalanyl) (Compound 5). Of these, compounds 1 to 3 are particularly preferred.

[0008]

Embedded image General formula (II) (where R represents a linear or branched alkyl group or alkenyl group that can have a cyclic structure having 8 to 22 carbon atoms)

[0009]

Embedded image Compound 1

[0010]

Embedded image Compound 2

[0011]

Embedded image Compound 3

[0012]

Embedded image Compound 4

[0013]

Embedded image Compound 5

[0014]

Embedded image Compound 6

All of the compounds of the present invention can be prepared from known compounds. These compounds may be produced, for example, by the following method. That is, 1,3,5-benzenetricarboxylic acid having a corresponding steric structure may be reacted with thionyl chloride to form an acid chloride, which may be reacted with the corresponding alkylamine or alkenylamine. The product of this reaction can be purified by ordinary purification means such as recrystallization and column chromatography.

<Production Example 1> Synthesis of Compound 1 1.6 g of aspartame, a catalytic amount of p-toluenesulfonic acid and 40 ml of 3,7-dimethyloctanol were heated at 160 ° C. under reduced pressure for 4 hours. The reaction product was extracted by adding 300 ml of petroleum ether, filtered, and allowed to stand at room temperature for 12 hours to collect a precipitate. Elemental analysis value (N: 6.76%,
C: 68.51%, O: 8.45%) and infrared absorption spectrum (3192, 1742, 1675 cm ^-1 )
Its structure was identified as compound 1. 1.54 g, 63% yield

<Preparation Example 2> Synthesis of Compound 2 Compound 3, was prepared in the same manner as in Preparation Example 1 except that 3,7-dimethyloctanol was changed to lauryl alcohol, and the same treatment was carried out in a yield of 54%.
I got

<Production Example 3> Synthesis of Compound 3 The same operation was carried out except that lauryl alcohol in Production Example 2 was changed to stearyl alcohol, to obtain Compound 3 in a yield of 61%.

<Production Example 4> Synthesis of Compound 4 The same operation was carried out except that lauryl alcohol in Production Example 2 was replaced with oleyl alcohol, to obtain Compound 4 in a yield of 46%.

<Production Example 5> Synthesis of Compound 5 The same operation was carried out except that lauryl alcohol of Production Example 2 was changed to 2-ethylhexyl alcohol, and Compound 5 was obtained in a yield of 52%.
I got

<Production Example 6> Synthesis of Compound 6 The same operation was carried out except that lauryl alcohol in Production Example 2 was replaced with cyclohexyl alcohol, to obtain Compound 6 in a yield of 55%.

Each of the compounds contained in the composition of the present invention thus obtained is excellent in the action of thickening and / or gelling the organic substance having fluidity or the composition. This action can stabilize compositions such as pharmaceuticals, cosmetics, and foods. This effect is also observed in a high temperature range around 40 ° C. In order to thicken and / or gel the organic substance or the composition using the present invention, 0.1 to 100 parts by weight, more preferably 0.5 part by weight, per 1 part by weight of the organic substance or the composition is used. -90 parts by weight, more preferably 1-
80 parts by weight may be added and heated to make them compatible. In this case, only one compound of the present invention may be used, or two or more compounds may be used. Examples of the organic substance capable of thickening and / or gelling the compound of the present invention include, for example, carbon tetrachloride,
Organic solvents such as tetrahydrofuran, hexane, cyclohexane, benzene, toluene, chlorobenzene, pyridine, etc., fuels such as kerosene, gasoline, light oil, heavy oil, olive oil, soybean oil, corn oil, castor oil, beef tallow,
Synthesis of animal and vegetable oils such as jojoba oil, mineral oils such as squalane, liquid paraffin, silicones such as dimethylpolysiloxane and methylphenylpolysiloxane, octyldodecyl oleate, glyceryl triisooctanoate, neopentyl glycol diisooctate, etc. Esters can be exemplified. Of these, the present compound can gel hydrocarbons such as liquid paraffin and squalane, cyclic dimethyl silicone, dimethicone, and the like, which were conventionally difficult to gel. Therefore, the present compound is suitably used for stabilizing cosmetics and medicines containing these components. Further, paints, foods, and the like can also be exemplified as compositions that can be stabilized by containing the compound represented by the general formula (I). The thickening / gelling action is shown below as test examples.

<Test Example> Thickening / Gelling Action Various organic components of 1 cm ^{3 were} weighed in a test tube, and the gelling action was examined using Compound 1, which is the most preferable representative example of the above compound. That is, an appropriate amount of Compound 1 was added, mixed, and heated and stirred until they were compatible. What was compatible 2
After cooling to 5 ° C., it was visually determined whether or not the gel was formed. Table 1 shows the results. It can be seen that Compound 1 has an excellent gelling effect on any organic substance.

[0024]

[Table 1]

(2) Composition of the Present Invention The composition of the present invention is characterized by containing the compound represented by the above general formula (I). As the composition of the present invention,
For example, medicines, cosmetics, foods and the like can be exemplified. In these compositions, cosmetics and medicaments are preferable, and among these cosmetics and medicaments, oily components are included in a large amount, and examples thereof include oil gel products and water-in-oil emulsion products. Specific preferred examples include, for example, pharmaceuticals, suppositories, water-in-oil emulsified skin external preparations, lipid preparations, liposome preparations, and the like, and cosmetics such as lip colors, eyeliners, and the like.
Oil gel products such as lip balms, foundations, etc., can be exemplified, for example, emulsified formulations having a large oil content such as manicure, pedicure, nail coat, etc., creams, foundations, etc. Fat products and the like can be exemplified. Of course, it is also possible to apply to stationery such as crayon, pencil and the like and construction supplies such as sealing agents and the like, which are also within the scope of the composition of the present invention.

The preferred content of the compound represented by the general formula (I) in the composition of the present invention is not particularly limited as long as a thickening effect can be expected. To 100 parts by weight, more preferably 0.5 to 90 parts by weight, still more preferably 1 to 80 parts by weight, 0.01 to 20% by weight, more preferably 0.1 to 20% by weight, based on the whole composition. It is from 0.05 to 18% by weight, more preferably from 0.1 to 16% by weight. In the composition of the present invention, the compound represented by the general formula (I) may contain only one kind or a combination of two or more kinds. The compositions of the present invention may contain, in addition to the compound represented by the general formula (I), optional components used in these compositions. Such optional components include, for example, hydrocarbons such as petrolatum and microcrystalline wax, esters such as jojoba oil and gay wax, triglycerides such as tallow, olive oil, higher alcohols such as cetanol and oleyl alcohol, and stearic acid. , Fatty acids such as oleic acid, glycerin and 1,
Polyhydric alcohols such as 3-butanediol, nonionic surfactants, anionic surfactants, cationic surfactants,
Amphoteric surfactants, thickeners such as ethanol and carbopol, preservatives, ultraviolet absorbers, antioxidants, pigments, powders,
Sweetening agents, sour agents and the like can be exemplified. The composition of the present invention is stable even in a body temperature range around 40 ° C. by the compound represented by the general formula (I), and does not impair the usability even at 5 to 10 ° C.

The present invention will be described in more detail with reference to the following examples, but it goes without saying that the present invention is not limited to these examples.

Examples 1-4 Formulation Examples A foundation was prepared according to the formulation shown in Table 2 below. That is, after mixing the powder components with a Henschel mixer, pulverizing with a pulverizer, putting this in a double planetary mixer, dissolving and adding the other components, kneading while heating, filling in a metal plate, heating and pressing to obtain a foundation. Was. In addition, the results of observation when this was stored at 40 ° C. for 3 months are shown. It can be seen that the composition of the present invention has improved stability. The evaluation criteria are ++: remarkable,
+: Clearly observable, ±: slightly observed,-: not observed at all. The usability at 5 ° C. was also evaluated by a specialized panel. Table 2 with the results
Shown in It turns out that the composition of the present invention has good usability at low temperatures.

[0028]

[Table 2]

<Examples 5 to 8> Creams were prepared according to the formulations shown in Table 3. That is, (a), (a), (c), and (d) were each dissolved or dispersed by heating at 80 ° C., (a) and (b) were kneaded, and this was diluted with (c), and (d) was gradually added and emulsified. This was stirred and cooled to obtain a cream. In addition, the results of observation when this was stored at 40 ° C. for 3 months are shown. It can be seen that the composition of the present invention has improved stability. The evaluation criteria were ++: marked, +: clearly observable, ±: slightly observed,-: not observed at all. The usability at 5 ° C. was also evaluated by a specialized panel. The results are shown in Table 3. It turns out that the composition of the present invention has good usability at low temperatures.

[0030]

[Table 3]

<Examples 9 to 12> Lipsticks were prepared according to the formulations shown in Table 4. That is, a was dispersed in a ball mill, and 90 ° C.
Heated. On the other hand, a, which was previously heated and dissolved and dispersed at 90 ° C., was added, mixed well, poured into a mold, cooled, and mounted in a container to prepare a lipstick. In addition, the results of observation when this was stored at 40 ° C. for 3 months are shown. It can be seen that the composition of the present invention has improved stability. The evaluation criteria are ++:
Remarkable, +: clearly observable, ±: slightly observed,-: not observed at all. The usability at 5 ° C. was also evaluated by a specialized panel. The results are shown in Table 4. It turns out that the composition of the present invention has good usability at low temperatures.

[0032]

[Table 4]

<Examples 13 to 16> Suppositories were prepared according to the formulation shown in Table 5 below. That is, the prescription components were dissolved and dispersed by heating, poured into a mold, and cooled and solidified to obtain a suppository. In addition, usability (dirty underwear and foreign-body sensation) was determined by a specialized panelist. The results are also shown in Table 5. It turns out that the composition of the present invention is excellent in use feeling.

[0034]

[Table 5]

<Examples 17 and 18> Creams were prepared according to the formulations shown in Table 6. That is, A, I, U, and D are each heated and dissolved or dispersed at 80 ° C., and A and B are kneaded,
This was diluted with c and further added gradually to emulsify. This was stirred and cooled to obtain a cream. At the same time, the panelists evaluated whether cosmetics stained tea bowls and the like. The results are shown in Table 6. It can be seen that the composition of the present invention has reduced adhesion.

[0036]

[Table 6]

<Examples 19 to 22> Production Examples A foundation was prepared according to Table 7 below. That is,
A, B, C, and D were each weighed, and K was well kneaded, diluted by adding B, and then heated to 80 ° C. The mixture was dispersed therein, and the mixture was heated and gradually heated to 80 ° C., and emulsified. The mixture was stirred and cooled to obtain a foundation. The change in the state when this was stored in a constant temperature room at 40 ° C. for 3 months is also described. The control example in which Compounds 1 to 4 were replaced with water was partially separated at 40 ° C. for 2 months. This shows that the foundation, which is the composition of the present invention, is more excellent in stability at high temperatures than the control example, which is usually considered to be excellent in stability.

[0038]

[Table 7]

Examples 23 to 26 Formulation Examples Nail colors were prepared according to the formulations shown in Table 8 below.
That is, b is uniformly dispersed and dissolved in b, and c is added thereto with stirring to uniformly disperse and dissolve. Color. The results of the storage test at 40 ° C. for 3 months are also shown. As a control, compounds obtained by replacing compounds 1 to 4 with bentonite were used. From these results, it can be seen that the nail color which is the composition of the present invention has excellent stability.

[0040]

[Table 8]

[0041]

According to the present invention, the stability is particularly 40 ° C.
It is possible to provide a composition for pharmaceuticals, cosmetics, foods, and the like, which is excellent in stability at near body temperature and usability at 5 to 10 ° C.

────────────────────────────────────────────────── ─── Continued on the front page (51) Int.Cl. ⁶ Identification code FI A61K 47/22 A61K 47/22 F C07D 239/22 C07D 239/22 (72) Inventor Koichi Iyanagi Kashio, Totsuka-ku, Yokohama-shi, Kanagawa Prefecture Town 560 Pola Kasei Kogyo Co., Ltd.

Claims (4)

[Claims] 1. A composition comprising a phenylalanine aspartate cyclic dipeptide derivative represented by the general formula (I). Embedded image General formula (I) (where R represents a linear or branched alkyl group or alkenyl group that can have a cyclic structure having 8 to 22 carbon atoms) 2. The composition according to claim 1, wherein the steric structure of the aspartic acid phenylalanine cyclic dipeptide is L or L represented by the general formula (II). Embedded image General formula (II) (where R represents a linear or branched alkyl group or alkenyl group that can have a cyclic structure having 8 to 22 carbon atoms) 3. The compound represented by the general formula (I) is cyclo (L-β-dimethyloctylasparaginyl-L-phenylalanyl) (compound 1), cyclo (L-β-laurylasparaginyl) -L-phenylalanyl) (compound 2) or cyclo (L-β-stearylasparaginyl-
(L-phenylalanyl) (compound 3).
Or the composition according to 2. Embedded image Compound 1 Compound 2 Compound 3 4. The composition according to claim 1, which is a cosmetic or a medicine.