JPH10139637A - Composition for external use for pet - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a composition for external use of pets, containing a perfume glycoside, having an action for inhibiting the generation of odor from the pets, and useful; for cleaning agents, grooming agents, etc. SOLUTION: This composition contains a perfume glycoside such as the β-galactopyranoside and/or α-galactopyranoside of methyl salicylate, menthol, thymol, cis-3-hexenol, vanillin or eugenol, preferably in an amount of 0.01-10wt.%. The composition for external use is referably used as a cleaning agent or a grooming agent.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an external composition for pets, and more particularly, to an external composition for pets used for cleaning or grooming pets and suppressing generation of odor from pets.

[0002]

2. Description of the Related Art The number of people who keep pets in a sense of distracting loneliness has increased rapidly with the recent nuclear family or small family. Also, for example, these houses are often kept indoors, especially indoors, together with humans because houses are becoming narrower and gardens are disappearing like apartments. For this reason, pet odor and metabolite odors such as urine, sweat, and sebum, which have not been a problem since they were kept in a garden or the like, are becoming a serious problem. One of the measures that have been taken to address such pet odor problems is to bathe pets frequently,
The odor is masked by room fragrance or the like, and these countermeasures have not been able to fundamentally solve the problem of pet odor. In other words, despite the increasing importance of measures against pet odors, no countermeasures have been found to fundamentally solve this problem. Was sought.

[0003] On the other hand, it is a known technique to improve the persistence of a fragrance by glycosylating a fragrance.
It has not been known at all that the odor from pets is suppressed by including the fragrance glycoside in the composition for external use for pets.

[0004]

SUMMARY OF THE INVENTION The present invention has been made in view of the above, and an object of the present invention is to provide an external composition for pets having an action of suppressing the generation of odor from pets.

[0005]

Means for Solving the Problems The inventors of the present invention have conducted intensive studies to solve the above-mentioned problems, and as a result, have found that pets using external compositions such as detergents and grooming agents containing flavor glycosides. It has been found that the generation of odor from pets can be remarkably suppressed by washing, grooming, etc., and completed the present invention.

That is, the present invention is an external composition for pets containing a fragrance glycoside. As the fragrance glycoside specifically showing the fragrance part of the fragrance glycoside contained in the external composition for pets of the present invention, fragrances such as methyl salicylate, menthol, thymol, cis-3-hexenol, vanillin, and eugenol Each glycoside can be mentioned.
In addition, examples of the flavor glycoside specifically showing the sugar moiety of the flavor glycoside used in the present invention include β-galactopyranoside of flavor and α-glucopyranoside of flavor.

Further, when the content of the fragrance glycoside in the external composition for pets of the present invention is specifically mentioned, the content may be 0.01 to 10% by weight based on the total amount of the composition. .

Further, specific examples of the external composition for pets of the present invention include pet cleaning agents and grooming agents.

[0009]

BEST MODE FOR CARRYING OUT THE INVENTION Hereinafter, the present invention will be described in detail.
First, the fragrance glycoside contained in the external composition for pets of the present invention will be described. (1) Fragrance Glycoside Used in the Present Invention As the fragrance glycoside used in the external composition for pets of the present invention, a compound having a hydroxyl group in the structural formula and having an aroma, that is, a hydroxyl group in the structural formula is used. Any flavor glycoside obtained by the ether bond between the flavor and the sugar can be used without any particular limitation.

As the fragrance having a hydroxyl group in the above structural formula, for example, methyl salicylate, menthol, thymol, cis-3-hexenol, vanillin, eugenol, phenethyl alcohol, linalool and the like can be mentioned. Salicylate, menthol, thymol, cis-3-hexenol, vanillin, eugenol and the like can be cited as preferred fragrances in the present invention in terms of good masking of off-flavors generated by pets.

The sugar moiety of the fragrance glycoside used in the present invention can be composed of a monosaccharide or a polysaccharide. Examples of the fragrance glycoside include pyranoglucoside, arabinoside, riboside and riboside of the fragrance, respectively. Nosylarabinoside, rhamnoside, maltotreoside, galactoside and the like can be mentioned. Among these fragrance glycosides, preferred fragrance glycosides in the present invention include α-glucopyranoside, β-galactopyranoside, β
-Mannopyranoside, α-maltoside and the like, and more preferably, α-glucopyranoside,
β-galactopyranoside and the like.

The perfume glycoside contained in the external composition for pets of the present invention may be one kind or two or more kinds of the above-described perfume glycosides. The fragrance glycoside used in the present invention is a compound in which a fragrance and a saccharide are linked by an ether bond as described above, so that the ether bond is easily cleaved by the action of a hydrolase or the like and decomposed into a saccharide and a fragrance. . The fragrance obtained by such hydrolysis has an effect of suppressing an off-flavor. The hydrolase has been confirmed by the present inventors to be contained in urine and saliva, a metabolite from the body, which cause the smell of pets, and the urine and saliva in the fragrance glycoside, When the metabolite is touched in any way, the ether bond of the fragrance glycoside is broken, and the fragrance is gradually separated, thereby suppressing the odor.

That is, if the fragrance glycoside is used to suppress the generation of off-flavors from pets, a component having an action of hydrolyzing the fragrance glycoside and separating the fragrance in the causative substance of the pet odor. , The necessary amount of fragrance is separated in response to this when it is necessary to suppress the generation of odor,
At other times, the fragrance is held in the form of a fragrance glycoside, and therefore, it can be said that the fragrance glycoside acts very effectively and efficiently to suppress the generation of off-flavors from pets.

Here, the hydrolase acting on the fragrance glycoside varies depending on the structure of the fragrance glycoside. However, the hydrolase contained in the urine and saliva of pets and metabolites from the body is not included. Among them, α-glucosidase, β-galactosidase, etc. were confirmed by the present inventors to be relatively high in the above-mentioned odor-causing substances as compared with other hydrolases, as shown in Table 1 below. As a result, preferred flavor glycosides used in the present invention include α-glucopyranoside, β-galactopyranoside and the like of the flavors as described above.

Table 1 shows the hydrolyzing enzymes contained in human urine and the contents of ethers obtained by reacting human urine with various glycosides of nitrophenol shown in the table in order to examine the contents of the enzymes. It is a table | surface which shows the result of having evaluated the amount of nitrophenol which isolate | separated by bond | disconnection cleavage (hydrolysis) large and small using the light absorbency in 405 nm as an index. In the table, +++ indicates that the amount of separated (generated) nitrophenol is large (light absorption at 405 nm is strong), and ++ indicates that the amount of generated nitrophenol is relatively large (light absorption of 405 nm is relatively strong). , + Indicates that nitrophenol is clearly generated (absorbs light at 405 nm),
“-” Indicates that nitrophenol was not generated or was slightly generated (does not absorb light at 405 nm or very slightly absorbed). In addition, the same test as described above has been carried out for hydrolases contained in dog urine and cat urine, and the same tendency as the results shown in Table 1 below has been confirmed.

[0016]

[Table 1]

The fragrance glycoside used in the present invention is a known substance, and its production method is already known as a conventional method. For example, it can be easily obtained by condensing a saccharide and a fragrance with silver nitrate or the like as a catalyst, or by condensing a saccharide with a fragrance in the presence of an enzyme such as glucosidase or galactosidase. In addition, since flavor glycosides are widely present in nature, they can be easily obtained by extracting and purifying from sources containing such flavor glycosides by ordinary methods. Among the various methods for producing such perfume glycosides, a method of condensing a saccharide and a perfume using an enzyme having good stereoselectivity is preferred in the present invention.

Further, in the flavor glycoside used in the present invention, a derivative of the flavor glycoside whose sugar moiety is derivatized by acetylation or the like is also treated as belonging to the category of the flavor glycoside used in the present invention. Will be

Next, the external composition for pets of the present invention containing the above-mentioned perfume glycoside will be described. (2) The external composition for pets of the present invention The external composition for pets of the present invention is characterized by containing one or more of the above-mentioned flavor glycosides.

The preferred content of the above-mentioned perfume glycoside in the composition for external use of the present invention is from 0.01 to 0.01 to the total amount of the composition.
The content is 10% by weight, more preferably 0.5 to 8% by weight, and still more preferably 1 to 5% by weight. If the content of the fragrance glycoside in the composition for external use is less than 0.01% by weight, the generation of odor from pets may not be sufficiently or continuously suppressed, and the content may exceed 10% by weight. The effect has leveled off and is not economical.

The composition to which the external composition for pets of the present invention is applied is not particularly limited as long as it is an external composition for pets.
Cleaning agents such as rinses, toning lotions, creams,
Examples include a grooming agent such as an emulsion, flour dust, an antifungal agent, and the like. Among them, the external composition for pets of the present invention can be preferably applied to a cleaning agent and a grooming agent. The external composition of the present invention can be produced by the same method as that for producing an ordinary external composition for pets, except that the above-mentioned perfume glycoside is blended. Further, as for the dosage form of the external composition for pets of the present invention, the same dosage form as that of a general external composition for pets can be used.

In the external composition for pets of the present invention, in addition to the above-mentioned perfume glycosides, optional components usually used in these external compositions may be appropriately contained according to the dosage form of the external composition. it can. Such optional components include, for example, hydrocarbons such as petrolatum and microcrystalline wax, esters such as jojoba oil and gay wax, silicones such as dimethicone and cyclic dimethicone, triglycerides such as tallow, olive oil, cetanol, and oleyl alcohol. And the like, higher fatty acids such as stearic acid and oleic acid, polyhydric alcohols such as glycerin and 1,3-butanediol, nonionic surfactants, anionic surfactants, cationic surfactants and amphoteric surfactants Thickeners such as ethanol and carboxyvinyl polymers, preservatives, ultraviolet absorbers, antioxidants, pigments, powders, antifungal agents such as bifonazole, miconazole, antibiotics such as penicillin, tetracycline, cephalosporin, Antiprotozoal agents such as metronidazole and benznidazole Ketoprofen, and the like anti-inflammatory agents such as indomethacin.

Furthermore, the composition for external use for pets of the present invention can contain a fragrance component other than the above-mentioned fragrance glycoside as long as the effect of the fragrance glycoside of the present invention is not impaired. The pet to which the external composition for pets of the present invention obtained in this manner is applied is not particularly limited as long as it is an animal usually kept as a pet, and specifically, dogs, cats, Hamsters, guinea pigs, mice and the like can be mentioned.

[0024]

Embodiments of the present invention will be described below. First,
A production example of a fragrance glycoside contained in the external composition for pets of the present invention will be described.

[0025]

[Preparation Example 1] To an aqueous solution obtained by dissolving 10 g of β-galactosylgalactose and 10 mg of β-galactosidase in 500 ml of water, a solution prepared by dissolving 1 g of methyl salicylate in 20 ml of acetonitrile was added and stirred at 37 ° C. for 48 hours. . Thereafter, the residue obtained by evaporating the solvent from the reaction solution under reduced pressure was purified by silica gel column chromatography (elution solvent: methanol: chloroform = 1: 1).
(Volume ratio)), ODS column chromatography (elution solvent; 10% by volume acetonitrile aqueous solution), Diaion HP-20 column chromatography (elution solvent: 2)
0 volume% ethanol aqueous solution → 50 volume% ethanol aqueous solution), and 124 mg of methyl salicylate-
β-galactopyranoside (hereinafter referred to as “flavor glycoside 1”) was obtained.

[0026]

[Preparation Example 2] 86 mg of menthol-β- was prepared in the same manner as in Preparation Example 1 except that 1 g of menthol was used in place of 1 g of methyl salicylate.
Galactopyranoside (hereinafter referred to as “flavor glycoside 2”) was produced.

[0027]

Production Example 3 131 mg of thymol-β-galactopyranoside (hereinafter referred to as “Production Example 1”) was prepared in exactly the same manner as in Production Example 1 except that 1 g of thymol was used instead of 1 g of methyl salicylate. Fragrance glycoside 3 ").

[0028]

Production Example 4 201 mg of cis-3-hexenol-β-galactopyrate was prepared in exactly the same manner as in Production Example 1 except that 1 g of cis-3-hexenol was used instead of 1 g of methyl salicylate. Noside (hereinafter referred to as "flavor glycoside 4") was produced.

[0029]

Production Example 5 108 mg of vanillin-β-galactopyranoside (hereinafter referred to as “Production Example 1”) was used in exactly the same manner as in Production Example 1 except that 1 g of vanillin was used in place of 1 g of methyl salicylate. Fragrance glycoside 5 ").

[0030]

Production Example 6 In the same manner as in Production Example 1 except that 1 g of eugenol was used instead of 1 g of methyl salicylate, 211 mg of eugenol-β-galactopyranoside (hereinafter referred to as “the eugenol-β-galactopyranoside”) was used. Perfume glycoside 6 ").

[0031]

Production Example 7 194 mg of phenethyl alcohol-β-galactopyranoside (hereinafter referred to as prepreg 1) except that 1 g of phenethyl alcohol was used in place of 1 g of methyl salicylate. Is referred to as “fragrance glycoside 7”).

[0032]

[Production Example 8] 86 mg of linalool-β-β- linalol was prepared in the same manner as in Production Example 1 except that 1 g of linalool was used instead of 1 g of methyl salicylate.
Galactopyranoside (hereinafter referred to as “flavor glycoside 8”) was obtained.

[0033]

[Production Example 9] 10 g of α-glucosylglucose and 10 g
A solution of 1 g of methyl salicylate in 20 ml of acetonitrile was added to an aqueous solution obtained by dissolving mg of α-glucosidase in 500 ml of water, and the mixture was stirred at 37 ° C. for 48 hours. Thereafter, the residue obtained by evaporating the solvent from the reaction solution is subjected to silica gel column chromatography, (elution solvent; methanol: chloroform = 1: 1 (volume ratio)), ODS column chromatography (elution solvent;
10% by volume acetonitrile aqueous solution), Diaion HP
Purified sequentially by -20 column chromatography (elution solvent; 20 vol% ethanol aqueous solution → 50 vol% ethanol aqueous solution), and 102 mg of methyl salicylate-α-glucopyranoside (hereinafter referred to as “flavor glycoside 9”) was obtained. Obtained.

[0034]

Production Example 10 108 mg of menthol was prepared in the same manner as in Production Example 9 except that 1 g of menthol was used in place of 1 g of methyl salicylate.
α-glucopyranoside (hereinafter referred to as “fragrance glycoside 1
0 ").

[0035]

[Production Example 11] 122 mg of thymol-α-α- was obtained in exactly the same manner as in Production Example 9 except that 1 g of thymol was used instead of 1 g of methyl salicylate.
Glucopyranosides (hereinafter referred to as "flavor glycosides 11") were produced.

[0036]

Production Example 12 171 mg of cis-3-hexenol-α-glucopyranoside (except that 1 g of cis-3-hexenol was used instead of 1 g of methyl salicylate in Production Example 9) Hereinafter, this is referred to as “flavor glycoside 12”).

[0037]

Production Example 13 89 mg of vanillin-α-glucopyranoside (hereinafter referred to as “fragrance glycoside”) was prepared in the same manner as in Production Example 9 except that 1 g of vanillin was used in place of 1 g of methyl salicylate. Body 13 ").

[0038]

Production Example 14 121 mg of eugenol-α-glucopyranoside (hereinafter referred to as “fragrance glycoside”) was prepared in exactly the same manner as in Production Example 9 except that 1 g of eugenol was used instead of 1 g of methyl salicylate. Body 14 ").

[0039]

Production Example 15 79 mg of phenethyl alcohol-α-glucopyranoside (hereinafter referred to as “perfume”) was prepared in exactly the same manner as in Production Example 9 except that 1 g of phenethyl alcohol was used in place of 1 g of methyl salicylate. Glycoside 15 ").

[0040]

Production Example 16 116 mg of linalool-was prepared in the same manner as in Production Example 9 except that 1 g of linalool was used in place of 1 g of methyl salicylate.
α-glucopyranoside (hereinafter referred to as “fragrance glycoside 1
6 ").

Next, examples of the external composition for pets of the present invention containing the fragrance glycoside obtained in each of the above Production Examples will be described.

[0042]

Examples 1-4 Shampoos for pets Shampoos for pets were prepared according to the formulation shown in Table 2. That is, the prescription components were dissolved by heating and cooled to obtain a shampoo for pets.

[0043]

[Table 2]

[0044]

Examples 5 to 8 Rinsing for pets Rinsing for pets was prepared according to the formulation shown in Table 3.
That is, the prescription components were dissolved by heating, stirred, and cooled to obtain a pet rinse.

[0045]

[Table 3]

[0046]

Examples 9 to 12 Pet Grooming Lotion Pet grooming lotions were prepared according to the prescription shown in Table 4. That is, the prescription components were dissolved by heating and cooled to obtain a grooming lotion for pets.

[0047]

[Table 4]

[0048]

Examples 13 to 16 Pet Grooming Lotion Pet grooming lotions were prepared according to the prescription shown in Table 5. That is, the prescription components were dissolved by heating and cooled to obtain a grooming lotion for pets.

[0049]

[Table 5]

<Evaluation of the external composition for pets of the present invention>
A practical use test was performed on the external composition for pets obtained in each of the above Examples, and the effect of suppressing the generation of odor from pets by the external composition for pets of the present invention was evaluated.

(1) Evaluation of Shampoo and Rinse The shampoo obtained in Example 1 and the rinse obtained in Example 5 were subjected to a use test by 20 households having indoor dogs. The method is to replace the conventional shampoo and rinsing currently used with the shampoo of Example 1 and the rinsing of Example 5, and have them use for 2 months in the same manner as the method of using the conventional product. A questionnaire asked which of the shampoo and the rinsing of the example was used to suppress the pet odor when using the shampoo and the rinsing. As a result, 3 families answered that the smell was suppressed when using the conventional product, 3 families answered that it did not change, and 3 families answered that the shampoo and rinse of the example were used. Eleven respondents said they had suppressed the disease, and said they did not know the remaining three families.

(2) Evaluation of grooming lotion For the grooming lotion obtained in Example 9,
We tested the use of the cats with 20 families. That is, the grooming lotion of Example 9 was filled in a spray bottle, and the cat was sprayed with 0.5 ml of the grooming once a day for 30 days every day. After the 30-day use period, we asked about the pet smell in a questionnaire.
Families reported that pet odor was improved by using the grooming lotion of the example.

From these results, it can be seen that the external composition for pets of the present invention has an effect of suppressing generation of odor from pets.

[0054]

The external composition for pets of the present invention has an effect of suppressing the generation of odor from pets.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁶ Identification code FI C11D 3/50 C11D 3/50 (72) Inventor Yasushi Yasushi 836 Otani, Shizuoka-shi, Shizuoka Pref. Shizuoka University Faculty of Agriculture (72) Inventor Watanabe Shuji 836 Otani, Shizuoka City, Shizuoka Prefecture Shizuoka University Faculty of Agriculture

Claims (6)

[Claims] 1. An external composition for pets containing a fragrance glycoside. 2. The external composition for pet according to claim 1, wherein the flavor glycoside is selected from methyl salicylate, menthol, thymol, cis-3-hexenol, vanillin or eugenol glycoside. 3. The external composition for pet according to claim 1, wherein the flavor glycoside is β-galactopyranoside and / or α-glucopyranoside of the flavor. 4. The external composition for pets according to claim 1, wherein the content of the fragrance glycoside is 0.01 to 10% by weight based on the total amount of the composition. 5. The external composition for pets according to claim 1, which is a cleaning agent. 6. The external composition for pets according to claim 1, which is a grooming agent.