JPH0984888A - Method for noninvasively reinforcing immunity-inspecting ability and tool for irradiating forehead region with pulse light - Google Patents

Abstract

PROBLEM TO BE SOLVED: To reinforce immunity inspection ability and concentrating force by irradiating the forehead region or the head contg. the forehead region of a user with a pulse light. SOLUTION: An elliptical bowl-shaped light emitting part 3 is fixed on the top part of the front face of a band type fitting tool 2 by means of a supporting member 4 and the fitting length of the fitting tool 2 is made adjustable by means of a Hook-and-Loop fastener 2a and an electrode 5 for brain wave is fixed on the side of the inside of the position where the light emitting part 3 is fitted and an electrode 6 for earth is fitted to the fitting tool 2 through a cord 61. The light emitting part 3 is constituted of the elliptical bowl-shaped light emitting tool 31 and a light source 32 and the front edge part 31a of the light emitting tool 31 is brought into tight contact with the forehead region of a user. When the forehead region pulse light irradiation tool 1 is fitted on the head part and a switch is turned on, the representative value of the α-rhythm picked up through the electrode 5 is displayed on a brain wave displaying part 81. This value is read and a dial is operated to fit it to the frequency and a pulse light with the same frequency or a frequency in a close region with the mean value of the self-α wave is emitted toward the forehead part from the light emitting part 3.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a method for non-invasively enhancing immunosurveillance, and a forehead pulsed light irradiation tool for embodying this method. More specifically, 0.5 to 1 on the frontal head or the head including the frontal head
The present invention relates to a method and apparatus for enhancing the immune monitoring ability by a non-invasive means of irradiating a pulsed light of 3 Hz, more preferably a pulsed light of 8 to 13 Hz, and at the same time, concentration.

[0002]

BACKGROUND OF THE INVENTION It has been known for a long time that cellular immunity, particularly NK cell activity, is easily reduced by mental and physical stress, and that the reduction is a major factor in tumor development. However, there are very few effective means to raise it. For example, activation of NK cells can be achieved by drugs (eg, poly 1: C) or cytokines (interleukin 2) that can be produced by genetic engineering techniques.
Etc.), but a large amount of administration over a long period of time causes resistance to the drug, and side effects cannot be ignored in the case of a drug.

At present, the relationship between α-waves and immunosurveillance such as NK cell activity has not been elucidated, but when there is little or no mental / physical stress, α-waves in the brain waves increase. Based on this fact, various attempts have been made that the stress is relieved if the α wave increases.

For example, for the purpose of relaxation and hypnosis, conventionally, a sound of a frequency in the α-wave region is heard,
It is practiced to apply pulsed light having a frequency in the wave region to the eyes. Weak electric currents of various wavelengths are generated from the human brain. Above all, the frequency called alpha wave is 8 ~
It is based on the theory that a 13 Hz electroencephalogram is often generated during a relaxation state, so that a relaxed state is induced by stimulation with this frequency. It is true that mental effects such as Zazen and stimulation from outside the body such as light causes α
It is true that the waves will increase. Also, α waves are often generated when consciousness is concentrated, but the frequency at that time (around 10 Hz or higher) is in a relaxed state (9 Hz).
It is slightly higher than that of the table or less). still,
It is said that β waves (14 to 30 Hz) during activity and excitement, θ waves (4 to 7 Hz) during sleep, and δ waves (0.4 to 4 Hz) during coma and deep sleep as well. ing.

Various α-wave stimulating means have been conventionally provided. The simplest one is to hear the sound of a tape or a CD recording the sound in the alpha wave region. As the light stimulus, for example, Japanese Patent No. 1150057.
In many cases, a lamp is provided around the lenses of glasses or goggles and a lamp lighting signal is output from the pulse signal generator to the lamp, as in Japanese Patent No. 4315502 and U.S. Pat. No. 4,315,502. In this way, when the closed eye is irradiated with pulsed light,
A phenomenon occurs in which the EEG is synchronized with the frequency of the pulsed light mainly in the occipital visual cortex through the visual pathway. This reaction is called a light-driven reaction. Further, for example, Japanese Patent Laid-Open No. 03-4453
As shown in FIG. 8, a technique has also been proposed in which a low-frequency current corresponding to an α wave is applied to both sides of the user's head.

However, since the output frequency of many of these is fixed, the effect is small or, on the contrary, the user may feel uncomfortable. That is, the α wave is a series of brain waves in the wavelength band of 8 to 13 Hz as described above,
Since each person has a unique rhythm of α-wave, the frequency band in which it easily appears is different, and the average value of the detected frequencies also differs from person to person. Further, even for the same person, the average value of the frequency band and the detected frequency slightly changes depending on the physical condition and time zone. Therefore, a stimulus whose frequency is too different from that of the α-wave emitted from the human body is not only effective but may even be harmful.

In order to solve this problem, a technique has been developed in which the electroencephalogram of the user is measured and a stimulus having a frequency equal to or close to the representative value of the α wave is applied. For example, in Japanese Patent Application Laid-Open No. 03-70572, a shading plate that covers the front of the user's eyes is provided at the face position of a headband, a light emitting unit is provided inside the shading plate, and an electroencephalogram signal measured by an electroencephalogram electrode is used. There is described an electroencephalogram guiding goggle that sends a light emission signal of the same frequency as the α wave to the light emitting section. These goggles are used by applying light to the eyes with the eyelids closed and relaxed. This technology is called optical feedback, and a kind of biological circuit that takes the user himself into a closed loop is formed, and the desired α-wave is strongly and promptly induced by the pulling action, and the user is promptly swung. It has the effect of pulling you into a relaxed state. This technology is disclosed as US Pat. No. 5,241967 (Japanese Patent Publication No. Hei 02-168932, and two others).

[0008]

However, in the case of optical driving, pulsed light hits the eyes no matter how the eyelids are closed. Therefore, some users may not be in a completely relaxed state due to the stimulation and the α wave may not increase. This problem cannot be solved by using optical feedback technology. Moreover, in the case of optical driving, there is a case where the blocked eyes are a definite disadvantage. That is, the α-wave has a function of enhancing motivation and concentration in addition to hypnosis and relaxation. Higher concentration increases the efficiency of mental activities such as reading, studying, studying, and writing activities, but it is impossible to perform these tasks if the eyes are closed.

Similarly, the sound in the α-wave region also interferes with reading, studying or thinking. Moreover, since the sound is monotonous, it may be frustrating depending on the user. on the other hand,
Flowing a low frequency wave to the brain disturbs the brain wave itself, and even a weak current is dangerous and should be performed under the guidance of a doctor. Therefore, it cannot be easily used by individuals.

Therefore, as a result of earnest research to solve these problems, the present inventor has obtained the following results.
That is, when the subject was irradiated with the pulsed light not on the eyes of the subject but above the forehead, a phenomenon was observed in which the α-wave component of the electroencephalogram derived from the forehead increased. And I was able to get a very good relaxed state, and my concentration increased. The forehead is the center of motivation, will and language, and it is thought that this center is activated by the increase of α waves, especially around 10 Hz or more. Moreover, surprisingly, it was confirmed that the subject's immune activity (NK cell activity value) increased during the pulsed light irradiation and for a while after that. This phenomenon has never been known so far, and its existence was first clarified by the present inventor.

[0011]

The method of the present invention has been completed on the basis of the results of experiments for confirming this phenomenon. Moreover, the forehead pulsed light irradiation tool of the present invention has been completed as a means for embodying this method.
Hereinafter, the present invention will be described in detail through experiments.

According to the method of the present invention, the subject's forehead or head including the forehead is irradiated with pulsed light, particularly pulsed light having a wavelength in the α-wave region, to enhance the immune monitoring ability and concentration of the subject. To do. Here, the immunosurveillance ability refers to the recognition and reaction (ie rapid destruction) of newly emerged abnormal cells containing new antigens caused by somatic mutation, such as malignant cells (cancer cells). It refers to the function of monitoring the immune system. The cells involved in this monitoring include macrophages, B cells, killer T cells,
There are NK cells and the like.

Among them, NK cells (natural killer cells)
Are cells that recognize virus-infected cells and cancer cells and give them damaging activity without requiring sensitization of antigens from the time of birth, and they play the most important role in immune surveillance to prevent carcinogenesis. It is a cell that fulfills. In addition, cancerous cells are disseminated from the developing lesion in a hematogenous and lymphatic manner,
It is also positioned as a local defense cell in so-called metastasis. Therefore, improving the activity of the NK cells is extremely important in the prevention and treatment of cancer. In this regard, it can be said that the irradiation of light in the α-wave region on the frontal region has a very important meaning.

It has been known that NK cell activity is enhanced by administration of virus and BCG, and is increased by interferon, interleukin 2 and the like. In the case of the method of the present invention, the NK cell activity is enhanced irrespective of drug administration, and there is no fear of side effects due to the drug. By the irradiation of pulsed light on the frontal region, norepinephrine in the catecholamine 3 fraction (adrenaline, noradrenaline, dopamine) was decreased, but no changes were observed in adrenaline, dopamine and β-endorphin. Further, the subject's mood was not deteriorated during the pulsed light irradiation, and there was no fear of side effects due to the pulsed light irradiation on the forehead in these ranges.

In the present invention, the frontal region (frontal region) means a so-called forehead portion of the face above the eyes and a peripheral portion thereof, and also includes a portion between the eyebrows. In addition, not only the frontal region but also the head region including the frontal region is irradiated with pulsed light. In the present invention, the head means a portion above the eyes. The mechanism by which enhanced NK cell activity occurs when the frontal region is irradiated with pulsed light is currently unknown. However, it is said that the sensory organs of the pineal gland exist in the frontal region, and there is a high possibility that it stimulates the pineal gland through this. However,
At present, the location of the sensory organ is unknown. Therefore, it is considered that the area of the frontal region including the eyebrow portion having a diameter of about 5 to 10 cm should be irradiated.

In the present invention, the pulsed light refers to intermittent light having a constant cycle, which is generated when a pulsed current is passed through a light source such as an LED. In the field of electricity, a pulse refers to a voltage or current having a waveform other than a sine wave, and generally means a square wave. The time from the rising of one wave to the rising of the next wave is called the cycle (T), and the reciprocal of the cycle f = 1 / T is called the repetition frequency. The frequency of the pulsed light referred to in the present invention is the repetition frequency. Strobe light is also included in the pulsed light of the present invention.
In addition, the one that intermittently blocks sunlight or general illumination light is also included. Irradiating such a pulsed light to the frontal region or the head is also a kind of optical stimulation.

In the case of the method of the present invention, irradiation of pulsed light on the eyes is not excluded. A tendency to enhance NK cell activity is also observed when pulsed light is applied to both the eyes and the frontal region. However, although the reason is not clear, no significant difference in the enhancement of NK cell activity was obtained when only the eyes were irradiated with the pulsed light, and even a tendency of reduction was observed depending on the user. On the other hand, when the eyes were hidden and the frontal region was irradiated with pulsed light, the activity of NK cells showed a significant enhancement. Therefore, it is preferable to hide the eyes when the purpose is to enhance NK cell activity. Regarding the α wave, in two cases where the pulsed light was irradiated to the above eyes, a large increase and an amplitude amplification were observed, especially in the occipital region.
On the other hand, when the eyes are hidden, the proportion of α-waves in the frontal region only increases. However, the forehead is the center of motivation, will, language, and irradiation of only the forehead is sufficient to increase concentration.

The method of irradiating the pulsed light in the present invention is not limited as long as it irradiates the forehead or the head including the forehead. For example, a wearing tool to which the light emitting unit is attached may be worn on the head of the user, or the forehead may be seen near the table lamp having the pulse light source. Alternatively, a wearing tool provided with a shutter that intermittently blocks sunlight or illumination light may be attached to the head so that the pulsed sunlight or illumination light is applied to the forehead. It is desirable that the irradiation of the pulsed light be performed in a state in which other light does not illuminate the frontal region at all or not so much and rested.

The frequency of the pulsed light is 0.5 Hz to 13 Hz, and more preferably 8 to 13 Hz, which is the α wave region. The range of 14 to 30 Hz is the β wave region and is not preferable because it causes an excited state. When the frequency is in the θ wave or δ wave region of 8 Hz or less, the effect of enhancing the immune monitoring ability and the concentration is not as great as that of the α wave, and the effect is greater as the frequency is higher. However, if there is a difference in the frequency of the user's electroencephalogram, not only does the enhancement effect not appear, but there is also the risk of a decrease.
It is preferable to irradiate the pulsed light having a typical value of the α wave obtained by measuring the electroencephalogram of the user or a frequency close thereto. The frequency may be selected manually. Most preferably, during the irradiation of the pulsed light, the electroencephalogram signal of the user is guided to the electroencephalogram guiding device, and the device induces α
That is, the signal component in the wave region is extracted, the representative value thereof is obtained, and the representative value or a value of a frequency close thereto is fed back as an irradiation signal. If you do this,
When the method of the present invention is carried out during sleep, the frequency can be gradually reduced from the α-wave region at bedtime to the θ-wave region during sleep, and there is an advantage that the user does not have to suffer physiological friction.

In the present invention, an LED is used as a light source for pulsed light.
However, this is because it is small and lightweight and easy to use, and is not particularly limited thereto. Any surface light emitter, tungsten lamp, or other artificial light source that emits visible light or infrared light can be used. With a brightness of 30 to 50 lux, a sufficient effect was obtained. Alternatively, sunlight or illumination light can be used. In this case, a wearing tool including a shutter that intermittently blocks sunlight or illumination light is attached to the head so that the pulsed sunlight or illumination light is applied to the forehead.

The experimental method and the results will be described below. [Experiment A] (Experimental device) An optical feedback device developed for the purpose of mental relaxation (hereinafter referred to as PFB device,
RELACTIVE 1: manufactured by Pioneer Co., Ltd.) was performed in the following manner. This device is composed of an easy chair on which a subject sits, band electrodes attached to the subject's head (two electrodes are fixed on both sides of the forehead), and a light source (6
60 nm red LED), α from a brain wave derived from the subject by a bandpass filter with a center frequency of 10.0 Hz
The control unit is configured to extract the wave component and control the frequency and amplitude of the pulsed light in real time according to the magnitude of the frequency and amplitude. Controlling the frequency of pulsed light in this way is called optical feedback (PFB). Also, a hat-shaped electrode (with 16 electrodes fixed)
Multi-channel biological amplifier (Biotop 6R12-4) manufactured by NEC Sanei Co., Ltd. and α-wave biofeedback device (FM
515: used after cutting the sound signal).
The hat-shaped electrode was used only for the 1st and 21st times, and the band electrode was used for the others (Experiment A (a)).

(Experimental Method and Results) Experiment A (a) Resting state (sitting chair sitting posture: inclination) for 13 healthy male subjects who are considered to be not mentally or physically stressed The experiment was carried out at an angle of 30 to 45 degrees without shielding the light from the eye. The illuminance of the pulsed light is about 30 lux (a state of being separated from the eye part by about 10 cm). The procedure of the experiment is as shown in FIG.
A total of 2 PFBs that emit pulsed light for 20 minutes from the front
The electroencephalogram was measured once each time, and changes in the electroencephalogram mainly of the α-wave component were examined. In addition, an experiment was carried out with the cap-type electrode attached for the first time and the 21st time, and blood was collected to examine changes in the immune monitoring ability. In this experiment A (a), since either the hat-shaped electrode or the band electrode was attached, the upper half of the forehead was shielded, and the irradiation amount of pulsed light on the forehead was low. .

When the PFB was performed, the effect of the electroencephalogram in the frequency band of 10.0 ± 0.5 Hz that appeared in each subject in the occipital region (O ₂ ) was compared to when the PFB was performed before the 21st PFB was performed. The amplitude tended to increase, but did not change significantly. A similar tendency was observed when comparing the other channels. However, the NK cell activity value (measured at an E / T ratio of 20: 1) increased in 6 out of 13 and decreased in 7 before and after the 21st PFB, and increased only after normal eye rest after that. Was observed (Fig. 1b).
Especially, in the blood sampling D and the blood sampling E, the statistical risk rate p is p <0.
Was 10.

Experiment A (b) The same experiment as Experiment A (a) was carried out on eight healthy male subjects who were considered to be mentally and physically unstressed. The difference from Experiment A (a) is that 16 dish-type electrodes are used without using the hat-type electrodes or band electrodes,
That is, the electrodes were attached to avoid the forehead, especially the forehead part, and the direction of the light source was changed so that the pulsed light mainly illuminates the forehead of the subject. The procedure of the experiment is the same as that of the experiment A (a) (FIG. 1 (a)), but the blood sampling A is omitted.

Compared to normal resting with eyes closed immediately before the 21st PFB, the average value of the electroencephalogram of the α-wave component that appeared in each subject in each channel during PFB was ± 0.5.
The effective amplitude of the electroencephalogram in the Hz frequency band was significantly increased. When this was compared between the channels, the tendency to increase in the parietal region and the temporal region was stronger than in the frontal region and the occipital region. In addition, as shown in FIG. 1 (c), the NK cell activity value increased in 5 out of 8 people and decreased in 3 people before and after the 21st PFB,
There was a tendency to increase before and after normal eye rest with PFB sandwiched (20 minutes for each), but it was not significant. Incidentally, FIG. 1 (d) shows the range of the average and the variation (standard deviation) of the values of each person in FIG. 1 (c), but as a whole, the NK cell activity at each blood collection tends to increase. I understand.

Through experiments A (a) and (b), the present inventor vaguely states that NK cell activity is increased by irradiating the frontal region with pulsed light having a frequency of about α-wave. I had high expectations. However, the irradiation of the pulsed light to the eye has a very large variation in the fluctuation of the NK cell activity, and in some cases, it may have an adverse effect. It is presumed that this is because, depending on the test subject, the pulsed light stimulation to the eye part feels stress. Therefore, the following experiment B and experiment C (partially unshielded) were performed with the eye part shielded.

[Experiment B] (Experimental Device) The optical feedback device (RE
LACTIVE 1: made by Pioneer) was partially modified and used. In the modification, the illuminance of the light source was increased to 50 lux (when separated by about 10 cm), and the mounting direction of the light source was changed so that the irradiation site was located in the center of the forehead. Also, 16 dish-shaped electrodes were used without using the hat-shaped electrode. The other devices were the same as those used in Experiment A.

(Experimental Method) An experiment similar to the experiment A was carried out on 7 healthy male subjects in a period when they were considered to be mentally and physically not stressed. Experiment A (a)
The difference is that the eye mask was used to shield the eyes, 16 dish-shaped electrodes were used without the hat-shaped electrodes, and electrodes were attached to avoid the frontal area, especially the forehead, and pulsed light That is, the direction of the light source was adjusted so that the frontal area of the subject was mainly irradiated. On the forehead, one dish-shaped electrode was attached to the right side of the forehead (close to temples: Fp ₂ ). The procedure of the experiment is as shown in FIG. 2 (a) (first and second PFB), FIG.
As shown in (b) (21st and 22nd PFB), all were carried out in 15 minutes. And the first and second times and 21.2
For the second time, after the eye rest for about 5 minutes, a normal eye rest period of 15 minutes was set, and then the first PFB (15 minutes) was performed by the above method, and then a normal eye rest for another 15 minutes. Set a period. In addition, the second PFB (15 minutes)
And again set a normal eye rest period of 15 minutes. Blood collection during the 21st and 22nd PFB was carried out in advance by inserting an indwelling needle into the medial cubital vein of the elbow so that blood collection during the experiment could be performed painlessly. In addition, 1 including blood collection
-The second and 21st and 22nd experiments were conducted at approximately the same time between 8:00 am and 12:00 am with room temperature and other environments as uniform as possible. NK cell activity was measured using ⁵¹ Cr at an E / T ratio of 50: 1.

(Experimental Results and Discussion) When a change in the α-wave component at the 1st and 2nd times and at the 21st and 22nd times of the PFB was examined by the multi-channel biological amplifier, no significant change was found. However, α detected on the right side of the frontal region (Fp ₂ ) with an electroencephalograph set in the Pioneer PFB device body
When the standard deviation (SD) of the electroencephalogram of the wave component was examined every 3 minutes after the start for 9 minutes, there was no change at the first PFB implementation, but it was significantly reduced at the 22nd PFB implementation. (Figure 3).

Although not shown in the figure, when the frequency of the pulsed light was set to 0.5 Hz and the subject's frontal region was similarly irradiated with the pulsed light eight times, the eighth electroencephalogram of the α-wave component was obtained. Standard deviation (SD) was slightly smaller for several minutes. However, the effect does not last so long, and the value itself is not
It was found that the frequency of the electroencephalogram of the α-wave component was more dispersed as a whole, as compared with the result of about 0 Hz). Moreover, when the same LED was continuously irradiated without pulsed light in the same manner as in Experiment B, centering around the subject's forehead, it became as small as the case of 0.5 Hz at the 8th time, but it still did not last long. all right.

In addition, in 2 out of 7 subjects, the 6th PF
In B, in one person 10 to 12 times PFB, a large increase in the amplitude of the α-wave component EEG, which is not seen in daily life, appeared in the frontal region mainly during the 15 minutes during which the light was applied. It was confirmed with the α-wave PFB device. Data of two of these three who were able to measure an electroencephalogram during the experiment without artifacts are shown in FIGS. 4 (a) and 4 (b). 15 minutes (3 minutes after starting 18
Α ₂ wave (9 to 11 Hz α wave) emitted from the frontal region until (minutes later)
The average value of the amplitude of 49.6μV, 42.0μV,
48.2 μV, which is the normal 15 before the first PFB implementation.
Compared with resting with eyes closed for 3 minutes, 3.53 times, 4.
It was 23 times and 4.76 times. In addition, the average value of the amplitude of the α ₂ wave in a normal person is around 10 μV.

These results show that a phenomenon similar to the light-driven reaction was applied to a part of the head (in this experiment It has occurred on the head).

The diagram (i) in the upper part of FIG.
Five frequency bands (θ, α ₁ , α)
₂ is a graph showing the appearance of a dominant electroencephalogram for each α ₂ , β ₃ ), the lower scale indicates elapsed time, and the numbers on the right indicate the total time (seconds) in which each EEG component was dominant. Note that ART was not measured. The middle chart (ii) is a graph showing the transition of the electroencephalogram amplitude in five frequency bands, and the lower chart (iii) is a graph obtained by extracting only the pulsed light irradiation from the chart (ii). Further, Table 1 (a) and Table 1 (b) are amplitude values of each brain wave in the five frequency bands at a certain time. 1/4 of this value becomes the voltage (μV). Table 1
(C) is the maximum value and the average value of the electroencephalogram amplitudes in the five frequency bands in the chart (iii). FIG. 4B, Table 2
(A), Table 2 (b) and Table 2 (c) show the data of the other person. In FIG. 4 and Tables 1 and 2, the θ wave is 4
~ 6Hz, α ₁ wave is 7 ~ 8Hz, α ₂ wave is 9 ~ 11Hz, α ₃
A wave is a brain wave component having a frequency of 12 to 13 Hz and a β wave having a frequency of 17 to 26 Hz.

This time, data was collected with the eye mask blocking the light that hits the eye, and the physiological phenomenon newly found was that if the eye was not exposed to light,
It may appear when the eyes are opened. When the pulsed light stimulus is applied to the forehead at a frequency and brightness suitable for the subject by using the PFB technique in the α-wave frequency band,
It was shown this time that the dramatic activation of the electroencephalogram of the α-wave component occurs with a certain probability. Thus, for example, when the device of the present invention is started to be used with the eyes open at a timing when the user starts to focus on mental activities such as study and work after the eyes are opened and the concentration is still continued, it is likely that the It is considered that the activated state of the waves can be relatively easily maintained and maintained or can be further enhanced by using this device.

On the other hand, NK cells are cells that recognize virus-infected cells and cancer cells and give them damaging activity without requiring sensitization of antigens from the time of birth, and are used for immune surveillance to prevent carcinogenesis. Are the most important immune cells in. Fig. 5 (a) shows before 2nd PFB implementation and 21.2
It is a graph which showed the change of the NK cell activity value (%) for each person during the second PFB implementation and before and after resting with the eyes closed. FIG. 5 (b) shows the average value and the variation (standard deviation) of the NK cell activity values of 7 persons. Further, Table 3 shows numerical values of the average value, the degree of freedom, the t value, and the p value of FIG. 5B at each stage (between A, B, C, ..., G). As can be seen from Table 3, the NK cell activity value is 21.
Compared to immediately before the 22nd PFB, p <0.005 immediately after.
, And 15 minutes after that, there is a significant increase of p <0.0001.

Although not shown, similar to the α-wave measurement described above, NK cell activity was measured twice for 15 minutes in accordance with FIG. 2 by pulsed light irradiation with a frequency of 0.5 Hz. .
As a result, the NK cell activity value did not change in half of the subjects 15 minutes after the irradiation, as compared with immediately before the two 15-minute irradiations, but slightly increased in 10% of the subjects (10 %) Was observed. This is the result when the number of irradiations was smaller than that in the above experiment, and at an extremely low frequency of 0.5 Hz. Therefore, more effects can be expected by increasing the number of irradiations and irradiating pulsed light having a frequency of about θ wave (4 to 8 Hz), which is said to increase during sleep. That is, the pulsed light whose center frequency is the frequency corresponding to the θ wave or the lower α wave generated by the user during sleep is P
It is speculated that if FB is performed, a sufficient effect can be obtained.

By the way, like the data obtained this time, 1
Until now, there has been no similar method including the use of drugs, which is a safe method for obtaining a large increase in the NK cell activity value around the time. Therefore, the implementation of the method of the present invention and the use of the device of the present invention make a great contribution to the prevention of carcinogenesis and the activation of virus-infected cells (for example, in the case of HIV carriers and herpesvirus subclinical infections). Speculated to fulfill.

Further, CD57x16 ++ in FIG. 6 and CD57x16- + in FIG. 7 (particularly the latter) are said to show quantitative changes in the expression of specific cell surface markers of NK cells. In this experiment, both of them show an increase or a tendency, but when the significance level is compared with the case of the activity value of NK cells in FIG. 5, it is found that both are slightly small. Therefore, each time the method of the present invention is repeatedly performed, it is considered that the NK cells increase their activity value. That is, it is estimated that NK cells are enhanced both in terms of quality and quantity. The effective use of the method and apparatus of the present invention in this way is safe and effective for enhancing the reaction of immunity (immunity called cell-mediated immunity) to "cells to be eliminated in the body" such as cancer cells. It is thought that it will have great significance in clinical and preventive medicine as a highly effective method.
Table 4 shows numerical values of the average value, the degree of freedom, the t value, and the p value of FIG. 6 at each stage (between A, B, C, ..., G), and Table 5 shows each stage (A , B, C, ..., G), the average value, the degree of freedom, the t value, and the p value in FIG. 7 are shown by numerical values.

In addition to the above-mentioned examination of the immune system, catecholamine 3 fractions (adrenaline, noradrenaline, dopamine) and β-endorphin were also examined (not shown).
Of these, noradrenaline significantly decreased before the 21st and 22nd PFBs (P <
0.05). Therefore, it is considered that by repeating the method of the present invention, relaxation of vascular smooth muscle and contraction of intestinal smooth muscle are promoted, blood flow is increased mainly in organs, and digestion is also improved, which in turn immunizes the living body. An environment that is advantageous for monitoring can be obtained. Further, it may be possible to bring about an antihypertensive effect even for patients with hypertension. No changes due to PFB were observed in the other three inspection items.

[Experiment C] (Experimental Apparatus) Using the improved PFB apparatus used in Experiment B, an experiment was conducted on the same person.

(Experimental method) 16 cases of right optic glioma in hospital
Experiments were carried out in an aged male patient before and during the period of interferon therapy after the use of anticancer drugs after surgery. The experiment method was performed with and without the shielding of the light from the eye. When the eye is not shielded from light before the operation (Experiment C-1), FIG.
(1st and 2nd times) and the procedure shown in FIG. 8B (21st and 22nd times) was performed. When the eye is not shielded from light after the operation (Experiment C-2), the procedure is as shown in FIG. 8 (c) (first and second time) and FIG. 8 (d) (21st and 22nd time). It was When the eye was shielded from light after the operation (Experiment C-3), the procedure was as shown in FIG. 8 (e). In addition, since the experiment C-3 was performed subsequent to the experiment C-2, there is no data for the first and second times. In each experiment, 22 times of 15 minutes of PFB were performed and 1
The changes in the electroencephalogram of the α-wave component and the immunosurveillance (NK cell activity was measured at an E / T ratio of 20: 1) were examined at the second time and the 21st and 22nd times.

(Experimental Results and Discussion) The above three types of experiments were carried out in this order. In each case, PFB was performed 22 times each for 15 minutes, and for the 1st and 2nd and 21st and 22nd PFBs, 5 brain waves measured by the α-wave biofeedback device (used without using sound signals) were measured. Band (θ: 4 to 6 Hz, α ₁ : 7 to 8 Hz, α ₂ : 9 to 11
_{Hz, α 3: 12~13Hz, β} : each band and amplitude of 17～26Hz) was examined the percentage of dominant and a time. Of these 5 frequency bands, α ₃ (12 to 13 Hz), which was the most easily activated by PFB in this subject, was used for the 21st and 22nd PFBs in each of the three experiments and for 15 minutes before and after that. 15 with normal eyes closed
The results of examining the average value of the amplitudes measured and calculated in each minute and the ratio of the time in which the band is dominant are shown by a bar graph shown as a set of two in each figure of FIG. . The hatched bar graph is the average output (μV) of the amplitude of the α ₃ wave (12 to 13 Hz) that appears,
The white bar graph shows the percentage (%) of the time (seconds) in which the α ₃ wave was dominant in the brain waves of the above-mentioned 5 bands. 9 (a) is experiment C-1, FIG. 9 (b) is experiment C-2, and FIG.
(C) is for Experiment C-3.

As can be seen, α ₃ by PFB implementation
Of activation was more obvious in the case where the light of the eye part was not shielded (Experiment C-1 and Experiment C-2). However, the NK cell activity value (broken line in each figure) measured at the same time hardly increased in Experiment-2, and Experiment C
In -1, the PFB was elevated twice, and the patient was kept in the normal eye rest for 15 minutes thereafter. On the other hand, in Experiment C-3 in which the light of the eye part was shielded,
21st PFB in which activation of α ₃ was observed and 1 after that
A clear rise was seen at 5 minutes of normal eye rest. Experiments C-2 and C-3 of this test subject were conducted in a situation where there are many factors that modify the immune system, such as interferon therapy being performed after the use of anticancer drug after brain tumor surgery. It was expected that clear data would not necessarily be obtained for both NK cell activity and NK cell activity. However, when the eye is shielded against light, a phenomenon similar to the light-driven reaction causes light to occur, as in Experiment B (and in Experiment C-1 it seems to occur in some cases). It is thought that it occurred on the applied head (the frontal area in this experiment).

As described above, even in the case of a cancer-bearing patient who is under immunologically special circumstances due to drug administration, etc., the method and apparatus of the present invention are repeatedly used (however, in a patient under such an environment). In the case, use intervals of once or 20 to 3
It is thought that it may be better to separate it for 0 minutes or more), and it is considered that the immune response to cancer cells can be extremely safe and enhanced together with the relaxation effect, and the effect as a therapeutic method for long-term use. There is expected.

(Forehead Pulse Light Irradiation Tool) Based on the results of various experiments described above, a frontal pulse light irradiation tool for embodying this method was developed. As described below, the first form of the forehead pulsed light irradiation tool of the present invention includes a user's forehead or forehead in a wearing tool that is detachably mounted on the user's head. A light emitting unit that radiates pulsed light is attached to the entire head. This form also includes one in which the wearing equipment itself serves as a light emitter. In addition, it is configured to include a pulsed light frequency adjusting unit, an electroencephalogram measurement electrode, a power supply unit, and a control unit for signal processing. The second form is a stand-type lighting device that is used in a sitting position or a supine position by using a base that is placed or fixed on furniture such as a desk, a chair, and a bed instead of the head-mounted device. , A base and a light emitting part are connected by an arm. The provision of the pulsed light frequency adjusting means and the like is the same as in the case of the first embodiment. The third mode is the same as the first mode in that the head mounting device is provided, but the fundamental difference is that sunlight or illumination light is used as a light source of pulsed light. . That is, a shield for concealing the user's forehead or the head including the forehead is attached to the wearing tool, and a shutter for intermittently blocking incident light is provided in the front opening of the shield. . The provision of pulsed light frequency adjusting means and the like is the same as in the first and second embodiments. Hereinafter, the forehead pulsed light irradiation tool of the first embodiment will be mainly described.

The mounting tool may be of any type and structure as long as it is firmly fixed to the head or the forehead of the user. A headband type (belt type), a headphone type, a hat type (helmet type), and the like can be considered, but it is desirable to provide an adjusting tool that can be firmly fixed according to the size of the head of the user. Further, the mounting tool includes a fixed body that can be attached to the frontal region by adhesion or suction.

The light emitting section is composed of a light source and a light emitter incorporating the light source. The type of light source is not limited, but an LED (light emitting diode) or the like is preferable in order to reduce power consumption. Visible light or infrared light can be used as the light source. The light emitting unit may be directly fixed to the wearing tool, or may be connected via an arm, a support plate or the like. Further, when the wearing tool is a helmet or an adhesive or suction type fixed body, the wearing tool itself may serve as a light emitting unit or a light emitting device. The light-emitting device may have a plate shape, a plate shape, or a bowl shape (cup shape). However, when there is a distance from the light source to the forehead, light may be scattered by the plate-shaped or dish-shaped light emitter to irradiate the eye. In the case of the present invention, the irradiation of pulsed light to the eye is not denied. However, when the pulsed light hits the eyes, the relaxed state is liable to be disturbed as described above, and it is necessary to avoid it when the user wants to exert his or her concentration, such as during reading. Therefore, when a plate-shaped or dish-shaped light emitter is used, it is desirable to provide an eye-shielding plate so that light does not hit the eyes. In the case of a bowl-shaped light emitter,
The front edge may be configured to be in intimate contact with or close to the forehead. Further, when using the device of the present invention in a bright place, it is desirable to provide a shield for covering the forehead to prevent other light from hitting the forehead, but in the case of a bowl-shaped light emitter , There is an advantage to achieve this work at the same time. The shape of the light emitter, especially for bowl-shaped ones,
The shape may be a circle or a horizontally elongated elliptical shape, but a vertically elongated elliptical shape or an inverted triangular shape is preferable for irradiating the forehead including the part between the eyebrows.

At least two electroencephalogram measuring electrodes, an electroencephalogram electrode and a ground electrode, are required. There is no limitation on the position where the electrode is installed, but especially in the case of an electroencephalogram electrode, if it is provided so that it can contact the forehead, the α wave (or α wave and θ wave) is generated more accurately and easily You can pick up the state. In this case, the central portion of the frontal region hinders the irradiation of the pulsed light, so that it is provided so as to come into contact with the side portion thereof, that is, the temple or the vicinity thereof. The ground electrode is usually attached to the earlobe before use. As the brain wave electrode, it is possible to use a brain wave measuring instrument which is completely different from the forehead pulse light irradiation tool of the present invention. In this case, it is not necessary to incorporate it in the wearing tool. However, if the electroencephalographic electrode is incorporated into the wearing tool, handling and operation will be simple, and especially the irradiation frequency will be the α wave (or α wave and θ) generated by itself.
Wave or theta wave), it is indispensable for the automatic adjustment type that matches the representative value.

An electroencephalogram display tool for displaying a representative value of frequencies in the α-wave region generated from the user's brain is connected to the electroencephalogram measurement electrode. This electroencephalogram display selects only the electroencephalogram in the α region picked up by the user with a filter (for example, a bandpass filter of 10 Hz), and calculates the average value, median value, peak average value, maximum value, etc. A representative value is calculated and displayed (digital or analog) in a form visually recognizable by an electronic display tube or the like, or a numerical value is read aloud. During use, the average value of self-alpha wave, etc.
A warning sound may be emitted when the frequency deviates from the frequency set by the user over a certain range (for example, around 0.5 Hz). When the electroencephalogram display device is directly incorporated in the wearing device, it becomes extremely difficult to use, especially in the case of the visual type. Therefore, it is preferable to configure the device separately from the main body (wearing tool) and exchange signals by wire, wireless, infrared rays, or the like.
However, in the case of the sound display type, in the case of a headphone type or helmet type wearing tool, it can be incorporated into the main body. This electroencephalogram display is not essential in the case of the automatic adjustment type, but may be provided in order to know the frequency of the self-α wave during use.

Next, the pulsed light frequency adjusting means will be described. This adjusting means is for irradiating pulsed light having a frequency equal to or close to the representative value of the self α-wave, and its configuration is different between manual and automatic. In the case of manual operation, this frequency adjustment tool
It consists of buttons and dials for selecting the representative value of the wave or a frequency close to it, and a scale showing the frequency. Then, the typical value of the self-alpha wave that is visually or heard (for example,
The pulsed light frequency is set to 0.1 to 0.2 Hz). However, if this operation is always performed, it becomes complicated and hinders relaxation and concentration of consciousness. Therefore, it is preferable to perform this operation at intervals of several minutes to several tens of minutes. In the case of the manual pulsed light frequency adjusting means, if this is configured separately from the main body (wearing tool), the operation can be performed easily and accurately. In this case, it is configured integrally with the above-mentioned electroencephalogram display device, similarly wired,
It is advisable to exchange signals with the main unit by wireless or infrared light.

In the case of automatic adjustment, since such an operation is performed by an electric circuit, an operation unit such as a button, a dial, and a scale for indicating a frequency becomes unnecessary. As an electric circuit of this kind, a brain wave signal of a user picked up by an electrode for measuring a brain wave is amplified, only a signal component of 8 to 13 Hz corresponding to an α wave is extracted by a filter, and a representative value thereof is obtained. The configuration is not limited as long as it outputs a pulsed light emission signal at the same or near frequency. In addition, as for the electroencephalogram of the user, the θ wave (4 to 8 Hz) is more likely to be dominant than the α wave (8 to 13 Hz) during sleep. Alternatively, there is a high possibility that a brain wave in which a lower α wave (8 to 9 Hz) and a θ wave are mixed is emitted. Therefore, in the case of the pulsed light frequency adjusting means, especially in the case of automatic adjustment, the representative value can be obtained by extracting the signal in the θ wave band or the α wave and θ wave band in consideration of sleeping. It is desirable to do so.
Alternatively, a plurality of bandpass filters having different transmission frequencies may be incorporated and used by switching between awake and sleep.

Whether manually or automatically, the light emitting section blinks by a light stimulus signal corresponding to the representative value of this α wave (or α wave and theta wave), and pulse light is emitted to the frontal region of the user. Irradiate to give stimulation. As a result, most of the electroencephalogram generated by the user is near the frequency range, and the relaxed state and the consciousness-focused state are favorably maintained and further improved. In addition, the forehead pulsed light irradiation tool of the present invention is in a relaxed state or a focused state to some extent (around 5 to 20 minutes).
If it is used after continuing, smooth electroencephalogram induction is performed, and no harmful effects such as feeling uncomfortable occur. From the above experimental results, when irradiation and rest are repeated every 10 to 20 minutes, an increase in NK cell activity may be seen even during rest. Therefore, the pulsed light irradiation may be continuously performed for a certain period of time, but the irradiation and the pause may be repeated at appropriate intervals. This control is performed manually or automatically by a timer or the like.

In addition to the above-mentioned components, the forehead pulse light irradiation tool of the present invention requires a control unit for signal processing and a power supply unit for the control unit and the light emitting unit. These may be incorporated in the main body (wearing tool), or may be integrated with the above-mentioned brain wave display tool and frequency adjusting tool in order to reduce the weight of the main body.

The above-mentioned frontal head pulsed light irradiating tool is used by the user by wearing it on his / her head. However, it may be troublesome to wear, and it may be an obstacle when sleeping. A stand-type forehead pulsed light irradiation tool addresses such a case. This forehead pulsed light irradiation tool is fixed to, for example, a shelf or a bed fence or placed on a desk, and the pulsed light irradiates the forehead of the user in a sitting or supine position. Use by adjusting the length and angle of. In this case, it is preferable to prevent the pulsed light from entering the eye by devising the shape of the light emitter or using an eye mask. If you are reading at a desk, irradiating pulse light from the front side of the top of the head while illuminating only the desk surface with strong light causes less reflection of pulse light on the desk surface. do not become.

The above-mentioned two types of forehead pulse light irradiating tools each have a light emitting portion. However, instead of the light emitting portion, a means for taking in sunlight or illumination light as pulsed light is incorporated. A forehead pulsed light irradiation tool is also conceivable. This type of forehead pulsed light irradiation tool is provided with a shield for hiding the user's forehead or a head including the forehead in the wearing tool, and a shutter for intermittently blocking incident light is provided on the wearing tool. It is provided at the front opening of the. In this case, the frequency of the pulsed light is determined by the number of times the shutter is opened and closed per unit time. The shutter may be mechanical, or may electrically control the transparency of the transparent body.

[0056]

BEST MODE FOR CARRYING OUT THE INVENTION The present invention will be described in more detail with reference to the embodiments shown in the drawings. 10A and 10B show an example of a forehead pulsed light irradiation tool of the present invention. FIG. 10A is a perspective view, and FIG. 10B is a side view with the head mounted on the head. This forehead pulsed light irradiation tool 1 is a kind of headband type, and an elliptic bowl-shaped light emitting part 3 is attached and fixed to the upper part of the front surface of a band type wearing tool 2 by two supporting members 4. . The mounting tool 2 has an attachment length that can be adjusted by a surface fastener 2a, and an electroencephalogram electrode 5 is fixed to the inner side of the location where the light emitting unit 3 is attached. The ground electrode 6 is attached to the wearing tool 2 via a cord 61. The light emitting section 3 is composed of an elliptic bowl type light emitter 31 and a light source 32 fixed to the bottom thereof, as partially enlarged in FIG. When it is mounted on the head as shown in FIG. 10B, the thinned front edge portion 31 of the light emitter 31 is attached.
a is brought into close contact with the forehead of the user.
Therefore, other light does not strike the frontal region, and the pulsed light does not illuminate the eye. In order to bring the light emitting unit 3 into closer contact with the forehead, the light emitting unit 3 and the mounting tool 2 may be connected by the auxiliary support member 4a as shown by the chain line in FIG. 10 (b).

Alternatively, as shown in FIG. 11, if the supporting tool 4 is omitted and the band as the wearing tool 2 is directly attached to the light emitting section 3, the frontal region including the eyebrows can be irradiated. . This also applies to the case of FIG. 13 described later and the like. In addition, there is a theory that the growth of hair is improved by stimulating the head with pressure, but in order to cope with this,
The band main body of the band-type wearing device 2 of FIGS. 10 and 11 may be formed of a hollow body such as a tube so that air can be pressed therein. Further, in the forehead pulsed light irradiation tool 1 of FIG. 10, a cord 7 extends from the wearing tool 2, and an operating portion 8 is attached to the tip thereof. The operation unit 8 has both an electroencephalogram display tool, a frequency adjustment tool, a control panel, and a power supply box, and includes an electroencephalogram display section 81, a frequency adjustment section 82, a switch 83, a clock 84, and a buzzer 85.

When the frontal head pulsed light irradiation tool 1 is used, if relaxation is intended, the user sits on a chair and continues to relax for about 5 to 20 minutes. Insert 83. When the purpose is to increase concentration, brain activity such as reading and calculation is similarly continued for about 5 to 20 minutes, and then, the person is put on the head and the switch 83 is turned on. Then, the representative value (average value, etc.) of the α waves among the brain waves picked up via the electrode 5 is displayed on the brain wave display unit 81. The user reads this value and operates the dial to tune to the corresponding frequency. Then, pulsed light having a frequency in the same band as or close to the average value of the self α wave is emitted from the light emitting unit 3 toward the forehead. If the light irradiation is continued, the typical value of the frequency of the self α wave may fluctuate (it tends to be lower in the case of relaxation and higher in the case of concentration). Therefore, a better result can be obtained by displaying the self-α-wave representative value at regular time intervals (for example, several to several tens of minutes) and adjusting the frequency of the irradiation light. In this example, the operation unit 8 is connected to the wearing tool 2 via the cord 7, but if the operation unit 8 is connected by wireless or infrared light (signal exchange), the degree of freedom of operation is increased. Increase. Further, the clock 84 may be used to indicate the elapsed time from the start of use, and the buzzer may be used to notify the end of the set time when the self α wave and the pulsed light frequency are deviated. Alternatively, instead of the buzzer, a speaker that indicates the current self-α wave information as an audio signal may be incorporated.

FIG. 12 is a schematic diagram showing an example of a circuit 9 for an operating section used when automatically adjusting the pulsed light frequency, unlike the above example. First, the electroencephalogram picked up by the electrode 5 is amplified by the amplifier 91, and is α by the filter 92.
The microcomputer 93 selects only those in the wave band.
To find the average value. Next, the level adjusting circuit 94 stabilizes the output level, and the LED drive unit 95 adjusts the voltage-
The light source 32 of the light emitting unit 3 is turned on by converting the current. still,
In the figure, operation parts such as a power source and switches are omitted. Further, reference numeral 12 in the drawing is an eye shielding plate.

FIG. 13 shows another example of a headband type frontal head pulsed light irradiation tool. This forehead pulse light irradiation tool 10
Is to support the light emitting portion 3 by the band 2 and the two supporting members 11. Since the light emitting unit 3 of this example has the dish-shaped light emitter 33, there is a possibility that light may illuminate the eye portion, and the eye shielding plate 12 is provided to prevent this. Reference numeral 13 is an antenna, which is wirelessly connected to an operation unit having a circuit illustrated in FIG.

FIG. 14 shows an example of a frontal head pulsed light irradiation tool in which the wearing tool is hat-shaped. This forehead pulsed light irradiating tool 14 has an elliptical bowl-shaped light emitting part 3 incorporated in a portion of the hat-type wearing tool 15 which is brought into contact with the forehead, and a chin strap for sure wearing 16 is provided. Also, reference numeral 17
Is an earphone that presents current self-alpha wave information and the like as an audio signal. If a light source for irradiating infrared rays, particularly far infrared rays, is incorporated inside the hat-type wearing device 15, it is considered that the scalp is stimulated to give good results for hair growth.
In this case, if the hat-type wearing device 15 is covered deeply in the eyes so that the frontal region can be irradiated with the pulsed light obliquely from above, the light emitting unit 3 can be omitted.

FIG. 15 shows an example of a frontal head pulsed light irradiation tool in which the wearing tool is a headphone type. In this forehead pulsed light irradiation tool 18, a support arm 20 is extended from the center of a headphone type wearing tool 19, and an elliptic bowl-shaped light emitting section 3 is attached to the tip of this support arm 20. The support arm 20 is configured to press the front head with a spring 21.

FIG. 16 shows an example of the forehead pulsed light irradiation tool 22 that can also be used as the eye-driving goggles. In this tool 22, the eye mask 23 has a bent portion 23a.
It can be folded by, and when it is opened as shown in FIG. 16 (a), it becomes a light driving goggle, and when it is closed as shown in FIG. 16 (b), it becomes a forehead pulse light irradiation tool. Code 2
4 is a band and 24a is a surface fastener. Depending on the user, depending on the time, it may be necessary to selectively use relaxation and enhancement of concentration. In such a case, the device capable of accomplishing both purposes by one is the frontal pulse light irradiation tool of this example.

FIG. 17 shows an example of a frontal head pulsed light irradiation tool 25 in which the wearing tool is different from the above examples. This forehead pulsed light irradiation tool 25 is a sticky body 2 with a flexible wearing tool.
6 and the light source 32 is embedded in the fixed body 26. The fixed body 26 has an adhesive layer 26b provided on one surface of a light-shielding main body 26a, and the fixed body 26 itself is the light emitter 3.
It also plays the role of 1. An electroencephalogram electrode 5 and an earth electrode 6 are provided on the fixed body 26 with a cord 51 and a cord 6 respectively.
Attached via 1. The frontal head pulsed light irradiation tool 25 is attached to the adhesive layer 2 near the center of the frontal head.
Fix with 6b. Measurement of the electroencephalogram and control of the pulsed light may be performed by the operation unit 8 as shown in FIG. Alternatively, as shown in the figure, when the management unit 27 in which the pulsed light frequency adjusting means, the power supply unit, the control unit and the like are downsized is integrated with the fixed body 26, the frontal head pulsed light irradiation tool 25.
The overall size and weight can be reduced, and it can be used comfortably even during sleep. Although not shown in the figure, the adhering member 26 may be an adsorbing member instead of an adhesive member. In the case of this kind of wearing equipment, since the light source can be brought into close contact with the frontal region of the head, there is an advantage that the brightness of the light source can be small.

FIG. 18 shows an example of a stand type forehead pulse light irradiation tool 40. The forehead pulse light irradiation tool 40 includes a base 41 provided with a fixture 41a and a light emitting section 4.
2 is connected by a displaceable and deformable arm 43. Then, the base 41 is fixed to a bed shelf 44 or the like, and pulse light is emitted to the forehead of a supine user. It is desirable that the pulsed light be applied in a ring shape, a semicircular shape, or a spot shape so that the pulsed light does not hit the eyes of the user as much as possible. If necessary, the eye mask 45 should be worn. Although illustration is omitted, a brain wave measuring electrode, a brain wave guiding device, and the like are also incorporated in this frontal region pulsed light irradiation tool. Alternatively, these are separated and connected by infrared light or the like.

Forehead pulse light irradiation tool 46 shown in FIG.
In place of the light emitting unit 3, the band 24 is fixed to a shield 47 that covers the user's forehead or the head including the forehead,
A shutter 48 that intermittently blocks incident light from the sun or a lighting fixture is provided in the front opening 47a of the shield 47. Reference numeral 24a is a surface fastener. The shutter 48 in this example is a combination of a frame plate 49 having a slit 49a and a rotary disc 50 having a slit 50a, and a motor 51 rotating the rotary disc 50. If a pulse motor is used as the motor 51,
The incident light draws a beautiful pulse. The frequency of the pulsed light is determined by the number and shape of the slits and the rotation speed of the disc 50. And
The electroencephalogram of the user is measured, and the rotation speed of the disk 50 is manually or automatically controlled by the same device as the irradiation light frequency adjusting means described above. In the figure, reference numeral 52 is a dimming plate for protecting the eyes from strong sunlight. The dimming plate 52 can be opened and closed vertically. A light shielding plate may be incorporated instead of the light attenuating plate 52. If two rotating discs are used instead of the frame plate 49 and one rotating disc 50, and the pulses are rotated in opposite directions by the pulse motor or at different rotational speeds, the light is evenly distributed on the forehead. Is irradiated. By using the forehead pulsed light irradiation tool 46, it is possible to easily and surely irradiate the forehead with a pulse of sunlight which is said to be good for the body. Although illustration is omitted, a brain wave measuring electrode, a brain wave guiding device, and the like are also incorporated in the forehead pulse light irradiation tool 46. Alternatively, these are separated and connected by infrared light or the like.

[0066]

As described above in detail, according to the method of the present invention, a pulse having a frequency of 0.5 to 13 Hz is applied to the user's forehead or the head including the forehead while shielding other light. Irradiation with light enhances immunosurveillance, especially NK cell activity, and concentration. Preferably,
The frequency of the pulsed light is set to a representative value of the α-wave band obtained by measuring the electroencephalogram of the user or a value close thereto, and the eye is shielded so that the pulsed light does not enter the eyes. As a result, various effects described below are achieved. (1) When pulsed light irradiation is performed with the eye part shielded, NK cell activity is enhanced and α in the frontal region is increased.
The wave component increased, a good relaxing state was obtained, and the effect of increasing concentration was obtained. However, when pulsed light is also applied to an eye part in a closed eye state, α-wave is significantly enhanced, but NK cell activity is not significantly enhanced. (2) The NK cell activation ability was also increased in cancer patients who were administered anticancer agents. (3) Since the pulsed light is simply applied to the forehead or the head including the forehead, it is extremely simple and
It is a completely non-invasive method that gives the user no pain, anxiety, or discomfort. (4) It has a large effect of activating NK cells and is significant in preventing carcinogenesis and cancer transfer. (5) NK without administration of drugs such as interferon
The cell activity is improved. Moreover, unlike drug administration and immunotherapy, resistance does not occur and side effects do not occur. (6) It is a safe method that can obtain a large increase in NK cell activity value by treatment for about 1 hour, and is superior to any conventionally known therapy or drug administration. (7) Since noradrenaline is reduced, an environment favorable for immune surveillance can be obtained. Moreover, other adrenaline, dopamine, β-endorphin, etc. do not change, and no side effects from this aspect are observed. (8) Since it is effective not only when awake but also during sleep,
It can be used for a long time. (9) The running cost is almost nonexistent, and the user is hardly burdened financially.

Further, the forehead pulsed light irradiation tool of the present invention comprises:
A light emitting unit for irradiating the user's forehead or the head including the forehead with a light having a frequency in the α-wave region, and a pulsed light frequency adjusting means,
Furthermore, the electroencephalogram measurement electrode is attached to a wearing tool which is removably attached to the head of the user. Therefore, the following various effects are exhibited. (1) It has a simple structure, can be downsized, and can be obtained at low cost. (2) Since the basic structure is a headband type, a hat type or a headphone type, or a fixed type by adhesion or adsorption,
Easy to use with no discomfort when attached to the head or forehead. (3) In particular, since the fixed type can be made extremely small, it is convenient for use at bedtime. Also, a stand-type kimono that is not worn on the head can be easily used in the supine position such as when sleeping. (4) When the main body and the operation unit are separated, the weight of the main body can be reduced. Further, if the main body and the operation unit are wirelessly or optically connected to each other, there is an advantage that the trouble during use is eliminated. (5) A device equipped with an electroencephalogram guiding device that obtains a representative value of the electroencephalogram in its own α-wave band and feeds it back as a pulsed light irradiation signal does not burden the brain even if it is used for a long time. It also has the effect of maintaining and improving a relaxed state or a state of mental concentration. (6) In the case where the eye-shielding means is provided, since the eye is not irradiated with the pulsed light, a completely relaxed state can be maintained, and an extremely good result in relaxation can be obtained. (7) A device provided with an eye-shielding means can withstand continuous use for a long time and can be used with the eyes open, so that it can be used in combination with other work. (8) If the device is provided with the eye-shielding means, it can be used while thinking, making calculations, and reading that require concentration. Therefore, the self-alpha wave changes into an alpha wave having a preferable frequency for activating mental activity, which further enhances the concentration and makes it optimal for studying for an examination. (9) When the frequency of the irradiation light is manually adjusted, the average value of the self α wave can be visually or audibly heard, so the operation is simple and reliable.

[Brief description of drawings]

FIG. 1 (a) is a graph of P in Experiment A (a) -irradiation with pulsed light from the front of the eye without shielding the light from the eye.
It is a work procedure figure which shows the procedure of FB implementation. Figure 1 (b)
[Fig. 4] is a graph showing changes in NK cell activity in Experiment A (a). FIG. 1 (c) is an experiment A (b) -irradiating pulsed light toward the forehead without shielding the light from the eye-
2 is a graph showing the change in NK cell activity in FIG. FIG.
1D is a graph showing the average of the values of each person in FIG. 1C and the variation (standard deviation) thereof.

FIG. 2 (a) is an experiment B-one dish-type electrode was attached to the right side of the frontal region of the head and the eye was shielded with an eye mask, and pulsed light was applied to the frontal region of the subject- 1.2 in
FIG. 2B is a work procedure diagram showing a procedure for implementing the PFB for the second time.
Is a work procedure diagram showing the procedure of 21st and 22nd PFB implementation.

FIG. 3 shows the right frontal region (Fp) every 3 minutes until 9 minutes after the start of PFB on the 1st and 22nd foreheads in Experiment B.
It is a graph which shows transition (n = 7) of standard deviation (SD) of the frequency of the alpha wave detected in ₂ ).

FIG. 4 (a) is one of the subjects in Experiment B.
A graph showing the appearance of dominant EEGs in each of the five frequency bands for humans (upper row), a graph showing the changes in the EEG amplitudes in the five frequency bands (middle row), and the transitions of the EEG amplitudes only during pulsed light irradiation. It is a graph (lower part) shown. FIG.
(B) is a similar graph for the other person.

FIG. 5 (a) shows the change in the NK cell activity value (%) for each person before the first PFB in Experiment B, during the 21st and 22nd PFB, and before and after the rest of the eyes closed. The graph shown in FIG. 5 (b) is a graph showing the average value and the variation (standard deviation) of the NK cell activity values of 7 persons.

FIG. 6 is a graph showing quantitative changes in CD57 × 16 ++ immediately before the first PFB implementation in Experiment B, during the 21st and 22nd PFB implementation, and before and after the eye closed at rest.

FIG. 7 is a graph showing quantitative changes in CD57 × 16− + immediately before the first PFB implementation, during the 21st and 22nd PFB implementation, and before and after the second PFB implementation in Experiment B and at rest.

FIG. 8 (a) is the first and second PFs in Experiment C-1—when the eye is not shielded from light before surgery.
FIG. 8 is a work procedure diagram showing a procedure for performing B. FIG. 8 (b)
It is a work procedure diagram which similarly shows the procedure of 21st and 22nd PFB implementation. FIG. 8C is a work procedure diagram showing a procedure of performing the first and second PFBs in the case where the eye is not shielded from light after the experiment C-2-after the experiment. Figure 8 (d)
Is a work procedure diagram showing the procedure of 21st and 22nd PFB implementation. FIG. 8E is a work procedure diagram showing a procedure of performing 21st and 22nd PFBs in the case where the eye is shielded against light after the experiment C-3-.

FIG. 9 (a) shows 21 · 22 in Experiment C-1.
NK during the second PFB and before and after resting with eyes closed
It is drawing which shows the change of a cell activity (line), the average output of the amplitude of the (alpha) ₃ wave which appeared (hatching bar graph), and the ratio (time bar graph) where the (alpha) ₃ wave was dominant. FIG.
(B) is a graph similar to FIG. 9 (a) in Experiment C-2. FIG. 9C is the same as FIG. 9 in Experiment C-3.
It is a graph similar to (a).

10A and 10B show an example of a forehead pulsed light irradiation tool of the present invention, in which FIG. 10A is a perspective view and FIG. 10B is a side view in a state of being worn on the head.

FIG. 11 is a perspective view showing another forehead pulsed light irradiation tool.

FIG. 12 is a schematic circuit diagram of an operation unit used when automatically adjusting the pulsed light frequency.

FIG. 13 is a perspective view showing a state in which another forehead pulsed light irradiation tool is attached to the head.

FIG. 14 is a perspective view showing a state in which another different frontal pulse light irradiation tool is attached to the head.

FIG. 15 is a perspective view showing a state in which another different frontal pulse light irradiation tool is attached to the head.

16A and 16B show an example of a forehead pulsed light irradiation tool that can also be used as a light-driving goggle. FIG. 16A is a perspective view showing a state of the goggles, and FIG. 16B is a frontal head pulsed light irradiation tool. It is a perspective view showing a state.

FIG. 17 is a perspective view showing another example of a forehead pulsed light irradiation tool with a different wearing tool.

FIG. 18 is a perspective view showing an example of a usage state of a stand-type frontal pulse light irradiation tool.

FIG. 19 is a perspective view showing an example of a forehead pulsed light irradiation tool that interrupts external light intermittently.

[Explanation of symbols]

1 Forehead pulse light irradiation tool 22 Goggle combined use 2 Band type wearing tool Forehead pulse light irradiation tool 3 Light emitting part 23 Eye mask 5 Electroencephalogram electrode 25 Forehead pulse light irradiation tool 8 Operation part 26 Fixed body 81 Brain wave display Part 26a Light-shielding main body 82 Frequency adjustment part 26b Adhesive layer 9 Circuit for operation part 27 Control part 91 Amplifier 40 Stand type 92 Filter Forehead pulse light irradiation tool 93 Microcomputer 41 Base 94 Level adjustment circuit 41a Fixed Tool 95 LED drive section 42 Light emitting section 0 Forehead pulse light irradiation tool 43 Arm 2 Eye shield plate 46 Incorporating a shutter 4 Forehead pulse light irradiation tool Forehead pulse light irradiation tool 5 Hat type wearing tool 47 Shield Tool 8 Forehead pulse light irradiation tool 47a Front opening 9 Headphone type wearing tool 48 Shutter

[Table 1]

[Table 2]

[Table 3]

[Table 4]

[Table 5]

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[Procedure amendment]

[Submission date] September 10, 1996

[Procedure amendment 1]

[Document name to be amended] Statement

[Correction target item name] Brief description of drawings

[Correction method] Change

[Correction contents]

[Brief description of drawings]

FIG. 1 (a) is a graph of P in Experiment A (a) -irradiation with pulsed light from the front of the eye without shielding the light from the eye.
It is a work procedure figure which shows the procedure of FB implementation. Figure 1 (b)
[Fig. 4] is a graph showing changes in NK cell activity in Experiment A (a).

[FIG.] Figure2(A) Experiment A (b) -Light on the eye
The pulsed light is directed toward the forehead without any shielding.
3 is a graph showing changes in NK cell activity in swelling. Figure2
(B) is a diagram2Average of each person's value in (a) and its variation
It is a graph which shows (standard deviation).

[3] FIG. 3 (a), experimental B- the eye as well as one mounted dished electrode on the right side of the forehead screened by eye mask, irradiated with pulsed light to the subject of the forehead - 1.2 in
Fig. 3 (b), a work procedure diagram showing the procedure of the PFB implementation for the second time
Is a work procedure diagram showing the procedure of 21st and 22nd PFB implementation.

FIG. 4 shows the right frontal region (Fp) every 3 minutes until 9 minutes after the start of PFB on the 1st and 22nd foreheads in Experiment B.
It is a graph which shows transition (n = 7) of standard deviation (SD) of the frequency of the alpha wave detected in ₂ ).

[Figure5] Figure5(A) is one of the subjects in Experiment B
Predominant EEG appearance graph for each of the five frequency bands for humans
(Upper row) and changes in EEG amplitude in five frequency bands
Graph (middle) and brain only when irradiated with pulsed light
It is a graph (lower part) which shows transition of the amplitude of a wave. Figure5
(B) is a similar graph for the other person.
You.

[6] FIG. 6 (a) 1st and before PFB embodiment in Experiment B, and the person changes in NK cell activity value (%) at the time of PFB embodiment 21, 22 th and longitudinal eye-closure resting its shows graphs, FIG. 6 (b) is a graph showing the mean and variation of NK cell activity value of seven (standard deviation).

FIG. 7 is a graph showing quantitative changes in CD57 × 16 ++ immediately before the first PFB implementation in Experiment B, during the 21st and 22nd PFB implementation, and before and after the PFB implementation.

FIG. 8 is a graph showing quantitative changes in CD57 × 16− + immediately before the first PFB in Experiment B, during the 21st and 22nd PFBs, and before and after the rest of the eyes closed.

[9] FIG. 9 (a), if not subjected to shielding against light on the eye with experimentally C-1-preoperative - in 1-second PF
FIG. 8 is a work procedure diagram showing a procedure for performing B. FIG. 9 (b),
It is a work procedure diagram which similarly shows the procedure of 21st and 22nd PFB implementation. FIG. 9 (c), the experimental C-2-case not subjected to shielding against light on the eye after surgery - a work procedure diagram showing the in 1-second PFB implementation procedures. Figure 9 (d)
Is a work procedure diagram showing the procedure of 21st and 22nd PFB implementation. Figure 9 (e) experimental C-3- postoperatively when subjected to shielding against light on the eye with - a working procedure diagram showing the in 21 and 22-th step in the PFB embodiment.

[10] FIG. 10 (a), 21-in Experiment C-1
Changes in NK cell activity during the 22nd PFB and before and after resting with eyes closed (polygonal line), average output of amplitude of α ₃ wave (hatched bar graph), ratio of time when α ₃ wave was predominant ( It is drawing which shows a white bar graph.
10 (b) is a graph similar to Fig. 10 (a) in Experiment C-2. Figure 10 (c) is a graph similar to FIG. 10 (a) in Experiment C-3.

11A and 11B show an example of a forehead pulsed light irradiation tool of the present invention, in which FIG. 11A is a perspective view and FIG. 11B is a side view in a state of being worn on the head.

FIG. 12 is a perspective view showing another forehead pulsed light irradiation tool.

FIG. 13 is a schematic circuit diagram of an operation unit used when automatically adjusting a pulsed light frequency.

FIG. 14 is a perspective view showing a state in which another forehead pulsed light irradiation tool is mounted on the head.

FIG. 15 is a perspective view showing a state in which another different frontal pulse light irradiation tool is attached to the head.

FIG. 16 is a perspective view showing a state in which another different frontal pulse light irradiation tool is attached to the head.

FIG. 17 shows an example of a forehead pulsed light irradiation tool that can also be used as a light-driving goggle. (A) is a perspective view showing the state of the goggles, (b) is a frontal head pulsed light irradiation tool. It is a perspective view showing a state.

FIG. 18 is a perspective view showing another example of a forehead pulsed light irradiation tool with a different wearing tool.

FIG. 19 is a perspective view showing an example of a usage state of a stand-type forehead pulse light irradiation tool.

FIG. 20 is a perspective view showing an example of a forehead pulsed light irradiation tool that interrupts external light intermittently.

[Explanation of Codes] 1 frontal pulsed light irradiation tool 2 band type wearing tool 3 light emitting section 5 brain wave electrode 8 operation section 81 brain wave display section 82 frequency adjusting section 9 circuit for operation section 91 amplifier 92 filter 93 microcomputer 94 Level adjustment circuit 95 LED drive unit 10 Forehead pulse light irradiation tool 12 Eye shield plate 14 Forehead pulse light irradiation tool 15 Hat type wearing tool 18 Forehead pulse light emitting tool 19 Headphone type wearing tool 22 Goggles combined front Head pulse light irradiation tool 23 Eye mask 25 Frontal head pulse light irradiation tool 26 Fixed body 26a Light-shielding body 26b Adhesive layer 27 Control unit 40 Stand type frontal head pulse light irradiation tool 41 Base 41a Fixing tool 42 Light emitting part 43 Arm 46 Forehead pulsed light irradiation tool incorporating a shutter 47 Shield 47a Front opening 4 Shutter

[Procedure amendment 2]

[Document name to be amended] Drawing

[Correction target item name] All figures

[Correction method] Change

[Correction contents]

FIG.

[Fig. 2]

[Figure 3]

FIG. 4

[Figure 5]

FIG. 6

FIG. 7

[Figure 8]

[Figure 9]

[Figure 10]

FIG.

FIG. 13

FIG. 14

FIG.

FIG. 11

FIG. 16

FIG.

FIG.

FIG.

FIG.

Claims (41)

[Claims] 1. A non-invasive immunosurveillance enhancing method, which comprises irradiating the frontal region of the user or the head including the frontal region with pulsed light. 2. The non-invasive immunosurveillance enhancing method according to claim 1, wherein pulsed light is irradiated in a dim atmosphere or a dark atmosphere. 3. The non-invasive immunosurveillance enhancing method according to claim 1 or 2, which comprises irradiating pulsed light with the eye part shielded. 4. The non-invasive immune monitoring according to claim 1, 2 or 3, wherein the irradiation of the pulsed light is performed from a light emitting part of a wearing tool which is detachably mounted on a user's head. Noh enhancement method. 5. The non-invasive immunosurveillance enhancing method according to claim 4, wherein the irradiation of the pulsed light is performed by a light source disposed inside the front head or the entire head covered with a shielding tool. 6. The non-invasive immunosurveillance enhancing method according to claim 1, 2 or 3, wherein the irradiation of the pulsed light is performed from an illuminating body that is not worn by the user. 7. The irradiation with pulsed light is performed by mounting a mounting tool having a shutter that intermittently blocks sunlight or illumination light on a head. 3. The method for enhancing non-invasive immunosurveillance as described in 3. 8. The non-invasive immunosurveillance enhancing method according to claim 1, wherein the irradiation of pulsed light on the frontal region and the irradiation of pulsed light are repeated at intervals of several minutes to several tens of minutes. 9. The frequency of the pulsed light is 0.5 Hz to 13 Hz
The method for enhancing non-invasive immune surveillance ability according to claim 1, wherein 10. The non-invasive immune monitoring ability enhancing method according to claim 9, wherein the frequency of the pulsed light is a representative value of α-wave obtained by measuring the brain wave of the user or a frequency close thereto. 11. The non-invasive immunosurveillance enhancing method according to claim 10, wherein a representative value of α-wave measured by an electroencephalograph or a frequency value close thereto is manually set. 12. An apparatus for guiding an electroencephalogram signal of a user to an electroencephalogram guiding device during irradiation of pulsed light, extracting a signal component in an α-wave region by the device to obtain a representative value of the representative value or a frequency close to the representative value. The non-invasive immunosurveillance enhancing method according to claim 10, wherein the value is fed back as an irradiation signal. 13. The method for maintaining the rest for several minutes to several tens of minutes in a state where the frontal head is not exposed to light, and measuring the electroencephalogram at that time to determine the frequency of the initial pulsed light. The method for enhancing non-invasive immune surveillance according to claim 11 or 12. 14. A forehead pulse light irradiation tool characterized in that a light emitting section for irradiating the user's forehead with pulsed light is attached to a wearing tool which is detachably mounted on the user's head. 15. The forehead pulse light irradiation tool according to claim 14, wherein a shield for preventing external light from hitting the forehead is attached to the wearing tool. 16. A forehead, which is equipped with a light emitting section for irradiating pulsed light to the entire head including the user's forehead, to a wearing tool which is detachably attached to the user's head. Pulsed light irradiation tool. 17. The forehead pulsed light irradiation tool according to claim 16, wherein a shield for preventing external light from hitting the entire head including the forehead is attached to the mounting tool. 18. The light emitting section comprises a light source and a light emitting device incorporating the light source.
The frontal pulse light irradiation tool according to 5. 19. The forehead pulsed light irradiation tool according to claim 14, 16 or 18, wherein an LED or a surface light emitter is used as a light source of the light emitting section. 20. The forehead pulsed light irradiation tool according to claim 19, wherein the front edge portion of the light emitter is close to or in close contact with the forehead of the user. 21. The forehead pulsed light irradiation tool according to claim 16, wherein the wearing tool itself serves as a light emitting section. 22. The forehead pulse light irradiation tool according to claim 14 or 16, wherein an eye shielding plate is attached to the wearing tool so that light from the light emitting section does not enter the eye. 23. The frequency of the pulsed light is 0.5 Hz to 13 Hz
The forehead pulsed light irradiation tool according to claim 14 or claim 16. 24. The forehead pulsed light irradiation tool according to claim 23, wherein the frequency of the pulsed light is a representative value of the frequency of the α wave generated by the user or a frequency close thereto. 25. The forehead pulsed light irradiation tool according to claim 14 or 16, wherein the wearing tool is provided with a means for adjusting the irradiation light frequency. 26. The forehead pulsed light irradiation tool according to claim 14 or 16, wherein an electroencephalogram measurement electrode is attached to the wearing tool. 27. The forehead pulse light irradiation tool according to claim 26, further comprising an electroencephalogram display tool for displaying a representative value of frequencies in the α-wave region connected to the electroencephalogram measurement electrode. 28. The forehead pulse light irradiation tool according to claim 27, wherein the electroencephalogram display tool is an analog or digital display that is visible. 29. The forehead pulse light irradiation tool according to claim 27, wherein the electroencephalogram display tool transmits a representative value of the frequency by an audio signal. 30. The forehead pulsed light irradiation tool according to claim 25, wherein the pulsed light frequency adjusting means is a manual frequency adjuster for matching the frequency of the pulsed light with the frequency shown on the electroencephalogram display. . 31. The frequency adjusting tool or the frequency adjusting tool and the electroencephalogram display are configured separately from the main body, and the main body is connected by wire, wireless or optical.
Alternatively, the forehead pulsed light irradiation tool according to claim 30. 32. The pulsed light frequency adjusting means extracts a signal component in the α-wave region and / or the θ-wave region of the electroencephalogram signal of the user obtained from the electroencephalogram measurement electrode, obtains its representative value, and the representative value Alternatively, the forehead pulse light irradiation tool according to claim 25, claim 26, claim 27, or claim 31, which feeds back a value of a frequency close thereto as an irradiation signal. 33. A stand-type illuminator that is placed or fixed on furniture such as a desk, a chair, and a bed, wherein a base and a light-emitting unit that emits pulsed light are connected by a displaceable or deformable arm. In addition, the frequency of the pulsed light is 0.5 to 13
A forehead pulsed light irradiation tool provided with a frequency adjusting means for adjusting to Hz. 34. An electroencephalogram measurement tool comprising an electroencephalogram measurement electrode,
34. The forehead pulsed light irradiation tool according to claim 33, which is integrally incorporated. 35. A stand-type illuminator that is mounted or fixed on furniture such as a desk, a chair, and a bed, wherein a base and a light-emitting unit that emits pulsed light are connected by a displaceable or deformable arm. At the same time, an electrode for measuring an electroencephalogram and a signal component in the α-wave region of the electroencephalogram signal of the user obtained from the electrode are taken out to obtain a representative value thereof, and the representative value or a value of a frequency close thereto is fed back as an irradiation signal A forehead pulsed light irradiation tool characterized in that an electroencephalogram guiding device is incorporated in a base. 36. The forehead pulse light irradiation tool according to claim 33 or 35, wherein an LED or a surface light emitter is used as a light source of the light emitting section. 37. The forehead pulsed light irradiation tool according to claim 36, wherein the light source has a ring shape, a semi-ring shape, or a spot shape. 38. A wearing tool which is removably mounted on a user's head is provided with a blocking tool for hiding the user's forehead or a head including the forehead, and interrupts incident light intermittently. A forehead pulsed light irradiation tool characterized in that a shutter is provided at the front opening of the shielding tool. 39. The forehead pulse light irradiation tool according to claim 38, wherein an electroencephalogram measurement tool including an electroencephalogram measurement electrode is integrally incorporated. 40. A wearing tool which is removably mounted on a user's head is provided with a blocking tool for hiding the user's forehead or a head including the forehead, and interrupts incident light intermittently. A shutter is provided at the front opening of the shield, and the electroencephalogram measurement electrode and α of the electroencephalogram signal of the user obtained from the electrode
A forehead pulsed light irradiating device, characterized in that a brain wave guiding device for extracting a signal component of a wave region, obtaining a representative value thereof, and feeding back the representative value or a value at a frequency close thereto as a shutter control signal is incorporated. 41. The wearing tool is a belt type, a headphone type,
The helmet type, or the fixed type that can be attached to the forehead by adhesion or adsorption.
The forehead pulsed light irradiation tool described.