JPH0947689A - Blood centrifugal separation and device thereof - Google Patents

Abstract

PROBLEM TO BE SOLVED: To make it possible to easily set a blood bag set in a centrifugal separator. SOLUTION: A rotor 2 fixed to a rotary shaft 1 has a plurality of arms arranged in the diametral direction, and a bucket 3 is supported by a retaining pin 6 at the tip part of paired arms adjacent to each other in the peripheral direction, in such a manner that the bucket 3 freely fluctuates in the diametral direction. The blood bag of a blood bag set is loaded in the bucket 3. In addition, a fixing metal 25 engaged with the retaining pin 6 and fitted with a filter 21 for removing leukocytes in freely detachable manner, is retained at the tips of the arms 5.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a method for centrifuging blood and an apparatus therefor.

[0002]

2. Description of the Related Art In recent years, whole blood is centrifugally separated by a centrifugal separator into three blood components, plasma, red blood cell concentrate and platelet concentrate, and only blood components required by a patient are transfused. Is widespread. The above centrifuge is
It has a rotating shaft that is driven to rotate, a rotor fixed to the rotating shaft, and a bucket. The rotor has a plurality of arms arranged in the radial direction and holding pins projecting from the tip of each arm to each side in the circumferential direction, and the bucket is attached to the holding pins of a pair of adjacent arms. It is held swingably in the radial direction.

When centrifuging whole blood with a centrifuge, a blood bag set is used. The blood bag set includes a blood collection needle, a blood collection blood bag in which the blood collection needle is connected via a blood collection tube and whole blood is collected, and a component separation component connected to the blood bag via the blood transfer tube. It is composed of a blood bag and a leukocyte removal filter interposed between blood transfer tubes. The leukocyte removal filter is a relatively hard plastic case that contains a filter material such as non-woven fabric or porous fiber material.
The leukocytes are removed when the centrifuged blood component is transferred from the blood collecting blood bag to the component separating blood bag. As a result, it is possible to prevent white blood cells from being mixed in the blood components, and to prevent side effects of blood transfusion.

By the way, the bucket of the centrifuge is originally designed to be compact in order to load a blood bag set consisting of only flexible members such as blood bags and tubes. Nevertheless, conventionally, a leukocyte removal filter having a relatively hard plastic case has also been loaded in the bucket.

[0005]

Therefore, the blood bag set is forcedly loaded into the bucket, which is difficult and time-consuming, and the blood bag set may be damaged during loading. there were. Further, during centrifugation, centrifugal force may act to push the leukocyte removal filter against the bottom surface of the bucket by the blood bag. In such a case, the leukocyte removal filter or blood bag may be damaged. However, there was a risk that the connection between the leukocyte removal filter and the blood transfer tube would be cut.

[0006]

In order to solve the above problems, the method of centrifuging blood according to the present invention is characterized in that a holding pin is provided at a distal end portion of a radial arm of a rotor of a centrifuge. Holds the bucket swingably in the radial direction, loads the blood bag of the blood bag set in which the blood bag and the leukocyte removal filter are connected by the tube into the bucket, and drives the rotor to rotate. In a method of centrifuging blood in a blood bag to centrifuge blood into respective blood components, a fixing tool engaged with a holding pin is held at the tip of an arm, and a leukocyte removal filter is fixed during centrifugation. The point is that it is detachably fixed to. The blood centrifuge of the present invention is characterized in that it has an arm arranged in a radial direction and a holding pin provided at the tip of the arm, and is driven to rotate and a holding pin. The blood bag of the blood bag set, which has a bucket that is swingably held in the radial direction of the rotor and in which the blood bag and the leukocyte removal filter are connected by a tube, centrifuges the blood loaded in the bucket. In the device, a fixing tool, which is engaged with the holding pin and detachably fixes the leukocyte removal filter, is held at the tip of the arm.

[0007]

BEST MODE FOR CARRYING OUT THE INVENTION The first embodiment of the present invention will be described below.
An example will be described based on the drawings in FIGS. As shown in FIGS. 1 to 4, the blood centrifugal separator has a rotating shaft 1, a rotor 2, a bucket 3, and the like. The rotary shaft 1 is arranged in the vertical direction and is rotationally driven by a drive device (not shown). The rotor 2 is fixed to the upper part of the rotary shaft 1, and has six arms 5 arranged radially (radially) horizontally at equal intervals in the circumferential direction and holding pins (holding means, gripping means).
6. The distal end portion of the arm 5 is an enlarged portion (support portion) 7 having a substantially triangular shape in a plan view, and the width in the circumferential direction increases as it goes outward in the radial direction. From each side surface in the circumferential direction of each enlarged portion 7, a holding pin 6 is provided so as to project on each side in the circumferential direction.

The bucket 3 is disposed between the tip ends of a pair of arms 5 which are adjacent to each other in the circumferential direction, and has a bottomed, substantially cylindrical shape. A pair of holding pin holes 12 are formed in the upper portion of the bucket 3 at radially symmetrical positions. The holding pins 6 of the pair of arms 5 adjacent to each other in the circumferential direction are removably engaged with the holding pin holes 12, so that the bucket 3 swings around the holding pin 6 on the rotor 2 in the vertical posture. It is held (grasped) freely.

A blood bag set 16 is used when centrifuging whole blood with a centrifuge. The blood bag set 16 includes a blood collection needle (not shown), a blood collection blood bag 18 in which the blood collection needle is connected via a blood collection tube 17 and whole blood is collected, the blood bag 18 and the like and a blood transfer tube. The blood bag 20 for component separation connected via 19 and the leukocyte removal filter 21 interposed between the blood transfer tubes 19 and the like.

The blood bags 18 and 20 have tubes 17 and 19 connected to the upper ends thereof, and a blood transfusion connection portion 23. The leukocyte removal filter 21 has a thin rectangular parallelepiped shape and a relatively hard plastic case 24 in which a filter material such as a non-woven fabric or a porous fiber material is incorporated. The centrifugally separated blood component is a blood bag 18 for collecting blood.
When transferred to the blood bag 20 for component separation from the white blood cells, white blood cells are removed. As a result, it is possible to prevent white blood cells from being mixed in the blood components, and to prevent side effects of blood transfusion.

Reference numeral 25 is a fixture, which is a leukocyte removal filter 2
1 is detachably fixed (held), and is releasably engaged with both holding pins 6 of a pair of arms 5 which are adjacent in the circumferential direction, and is held by both enlarged portions 7 of both arms 5. As shown in FIGS. 5 and 6, the main body 26 and a pair of left and right leaf springs 27 are included. The main body 26 is substantially in the shape of a gate, and is composed of a pair of left and right side walls 28 and a top wall 29 connecting the upper ends of the side walls 28. At the lower end of each of the left and right side walls 28,
A semicircular cutout portion 30 that opens downward is formed, and the cutout portion 30 is disengageably engaged with each holding pin 6, and the fixture 25 is positioned with respect to the enlarged portion 7. Further, each side wall 28 is inclined so as to move outward as it goes downward before being attached to the rotor 2, and when attached to the rotor 2, each side wall 28 is circumferentially deformed while elastically deforming inward. It is pushed in between the enlarged portions 7 of the pair of arms 5 adjacent in the direction.
As a result, each side wall 28 is pressed against each enlarged portion 7 by its elastic return force, and the fixture 25 is fixed to the rotor 2 in the vertical posture. The phantom line in FIG. 5 indicates each side wall 28.
Shows the position when the is attached. Fixture 2 as described above
Since 5 is attached to the rotor 2 using the holding pin 6, the fixture 25 can be easily attached to the rotor 2 with a simple structure. The pair of left and right leaf springs 27 are provided so as to project upward from both left and right sides of the ceiling wall 29 of the main body 26, and the projecting portions are corrugated. In addition, leaf spring 1
4 may be fixed to the top wall 29 in a non-detachable manner by riveting, welding, or other means, or may be detachably attached by bolting or other means.

According to the above example, the blood bag set 16
When whole blood is collected in the blood collecting blood bag 18 and then the blood bag set 16 is set in the centrifuge, the white blood cell removal filter 2 in the blood bag set 16 is used.
Blood bag 18 and 20, excluding 1, blood collection needle, tube 1
7, 7 and the like are loaded into the bucket 3, and the leukocyte removal filter 21 is held between a pair of leaf springs 27 of the fixture 25 via elastic deformation and fixed.

In addition, the blood bags 18, 20 and the like are placed in the bucket 3
When loading into the
The blood bags 18 and 20 are vertically loaded in the bucket 3 so that the blood bag 5 does not interfere with the above-mentioned loading and the blood bags 18 and 20 are arranged in parallel in the radial direction of the rotor 2. Further, the blood transfusion connection portion 23 of the blood bag 18, 20.
In order to prevent damage, the connecting portions with the tubes 17 and 19 are projected above the bucket 3 so as not to come into contact with the wall of the bucket 3. It is preferable that the blood collecting blood bag 18 or the like containing blood and medicines is arranged between the empty blood bags 20, and the tubes 17 and 19 are bundled and wound within a reasonable range. , 20 between them as appropriate.

As described above, the blood bag set 16
Is set in the centrifuge, and the rotary shaft 1 is driven to rotate. As a result, the rotor 2 and the bucket 3 are rotationally driven, and the centrifugal force causes the bucket 3 to swing around the holding pin 6 to be in a substantially horizontal posture as shown in FIG. Whole blood is centrifuged into three blood components: plasma, red blood cell concentrate, and buffy coat layer.
Since the fixture 25 is fixed to the rotor 2, the fixture 25 maintains the vertical posture during the centrifugal separation. As described above, during centrifugation, the bucket 3 loaded with the blood bags 18 and 20 rocks in a substantially horizontal position while the fixture 25 to which the leukocyte removal filter 21 is fixed maintains a vertical position, Leukocyte removal filter 21 and blood bag 18,
Since the relative position with respect to 20 changes, the blood transfer tube 19 that connects the leukocyte removal filter 21 and the blood bags 18 and 20 needs to be pulled out from the bucket 3 for a sufficiently long time or should be able to be pulled out smoothly. is there.

As described above, the leukocyte removal filter 21
To the outside of the bucket 3 and the blood bag set 1
Since the blood bags 18 and 20, the blood collection needles, the tubes 17 and 19 except the white blood cell removal filter 21 in 6 are loaded in the bucket 3, the blood bag set 16 can be easily set in the centrifugal separator in a short time, and There is no fear that the blood bag set 16 will be damaged during the setting. Further, since the leukocyte removal filter 21 is outside the bucket 3, the leukocyte removal filter 21 is not pressed against the bottom surface of the bucket 3 or the like by the blood bags 18 and 20 at the time of centrifugation.
There is no fear that the blood bags 18, 20 or the like will be damaged, or that the connecting portion between the leukocyte removal filter 21 and the blood transfer tube 19 will be cut.

FIGS. 7 to 9 show a second example of the embodiment of the present invention, and a fixing tool 25 is detachably attached to the enlarged portion 7 of one arm 5 and the holding pins 6 on both sides thereof. . The top wall 29 of the fixture 25 has a shape that is substantially similar to the enlarged portion 7 in a plan view, and is close to or abuts the enlarged portion 7. Further, each side wall 28 of the fixture 25 is close to or in contact with each circumferential side surface of the enlarged portion 7. At the time of centrifugation, the rotor 25 is prevented from moving outward in the radial direction due to the engagement between the fixture 25 and the holding pin 6 and the contact between the fixture 25 and the enlarged portion 7. The leaf springs 27 are arranged on the inner peripheral portion and the outer peripheral portion of the ceiling wall 29 of the fixture 25, and the leaf springs 27 arranged on the outer peripheral portion.
Thereby, the centrifugal force acting on the leukocyte removal filter 21 is sufficiently received. In the embodiment, the fixture is detachably attached to the rotor, but it may be fixed in advance in a non-detachable manner by welding, riveting or the like.

[0017]

As described in detail above, according to the present invention,
The blood bag set can be easily set in the centrifuge in a short time, the blood bag set is not likely to be damaged during the setting, and the leukocyte removal filter or the blood bag may be damaged or the white blood cells may be damaged during centrifugation. There is no risk of the connection between the removal filter and the tube being cut.
Further, since the fixing tool is attached to the rotor by using the holding pin, the fixing tool can be easily attached to the rotor with a simple structure.

[Brief description of drawings]

FIG. 1 is a perspective view showing a first example of an embodiment of the present invention.

FIG. 2 is a sectional plan view of the same part.

FIG. 3 is a sectional side view of the same part.

FIG. 4 is a partial cross-sectional side view showing the same operating state.

FIG. 5 is a partial cross-sectional front view of the fixture.

FIG. 6 is a side view of the fixture.

FIG. 7 is a plan view showing a second example of the embodiment of the present invention.

FIG. 8 is a sectional side view of the same portion.

FIG. 9 is a perspective view of the fixture.

[Explanation of symbols]

 1 Rotating Shaft 2 Rotor 3 Bucket 5 Arm 16 Blood Bag Set 17 Blood Collection Tube 18 Blood Collection Blood Bag 19 Blood Transfer Tube 20 Component Separation Blood Bag 21 Leukocyte Removal Filter 25 Fixing Tool 26 Main Body 27 Leaf Spring 30 Notch

Claims (2)

[Claims] 1. A rotor of a centrifugal separator, wherein a bucket is swingably held in the radial direction by a holding pin at the tip of a radial arm, and a blood bag and a leukocyte removal filter are connected by a tube. A blood bag of a blood bag set consisting of the following is loaded into a bucket, and the rotor is rotationally driven to centrifuge the blood in the blood bag into blood components. A method for centrifuging blood, comprising holding a fixture engaged with a holding pin, and detachably fixing a leukocyte removal filter to the fixture during centrifugation. 2. A rotor, which has a radially arranged arm and a holding pin provided at the tip of the arm, is driven to rotate, and is held by the holding pin so as to be swingable in the radial direction of the rotor. A blood bag of a blood bag set, which has a bucket that is connected to a blood bag and a leukocyte removal filter by a tube, is attached to a holding pin at the tip of an arm in a centrifuge for blood loaded in the bucket. A centrifuge for blood, characterized in that a fixture to which the leukocyte removal filter is detachably secured is held.