JPH09276368A - Blood bag set - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a blood bag set. With the blood bag set, separation processes to various blood constituents can be performed in germ-free conditions, and thus, recoveries of blood constituents can be performed under favorable conditions. SOLUTION: A blood bag set consists of the following constituents. Namely, they are a blood bag 2 which contains anti-coagulant for blood, a bag 5 which contains liquid medicines, a bag 9 which contains red blood cells and is connected to the bag 5 containing liquid medicines, a bag 11 which contains blood plasma and is connected to the bag 9 containing red blood cells, and a filter 7 which is to remove white blood cells and is placed at a path between the bag 9 and a parallel position with the bags 2 and 5.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a blood bag set for removing leukocytes in blood.

[0002]

2. Description of the Related Art In recent blood transfusion therapy, component transfusion in which only blood components required by a patient are transfused, and the collected blood is aseptically separated into blood components such as plasma, platelets and red blood cells. Is required. In general, blood collected and collected in a blood collection bag is centrifuged. Since the specific gravity of blood is slightly different for each component, the component layers are separated from the upper layer of the blood collection bag in the order of plasma, platelets, white blood cells, and red blood cells by the load of centrifugal force. Then, the plasma and platelet component layers having a low specific gravity are transferred from the tube above the blood collection bag to the blood component separation bag, and the red blood cells are left in the blood collection bag for storage. At this time, the white blood cells of the middle layer are mixed into each component,
Since this causes side effects due to blood transfusion, it is necessary to remove leukocytes.

Known methods for removing leukocytes in blood include the washed red blood cell method, the thawed red blood cell method, and the white blood cell removal filter method. Among them, the filter method that obtains a high leukocyte removal rate by a simple operation is widely used.

A blood bag system using such a leukocyte removal filter is disclosed in US Pat. No. 4,596,657.
Has been proposed. In this method, at least two bags are connected to a blood collection bag, and a leukocyte removal filter is incorporated between the blood collection bag and the bag containing a red blood cell preservation solution. The method of use is to centrifuge whole blood in a blood collection bag, transfer the plasma containing platelets to a bag not connected to a leukocyte removal filter, and then transfer the red blood cell preservation solution to the blood collection bag through a leukocyte removal filter. The concentrated red blood cells mixed with are passed through a white blood cell removal filter to remove white blood cells. However, this method has the following problems. White blood cells contained in concentrated red blood cells can be removed, but white blood cells mixed in plasma containing platelets cannot be removed. Since the leukocyte removal filter is centrifuged together with the blood bag in the centrifuge, the container and bag of the leukocyte removal filter may be damaged.

As a solution to this problem, Japanese Patent Publication No. 6-59
Japanese Patent No. 305 has been proposed. This uses a blood separation bag device in which the blood collection bag on the upstream side of the leukocyte removal filter and the blood component separation bag on the downstream side are aseptically connected, and the whole blood in the blood collection bag is passed through the leukocyte filter. In this method, white blood cells are removed and then centrifuged to separate blood plasma containing platelets and red blood cells. However, even with this method, the air that has flowed out of the leukocyte-removing filter is mixed with the blood from which leukocytes have been removed, so that there is a problem in that the cell function deteriorates when the blood components are preserved and it cannot be preserved for a long time.

[0006]

SUMMARY OF THE INVENTION The present invention has been made in view of the above circumstances, and can remove leukocytes mixed in plasma containing platelets, and remove the leukocyte removal filter when centrifuging. It is possible to provide a blood bag set that is capable of collecting blood components in good condition without the risk of air being mixed into the blood components when removing leukocytes in blood. To do.

[0007]

SUMMARY OF THE INVENTION The present invention provides a blood collection bag containing a blood anticoagulant, a drug solution bag communicating with the blood collection bag, and a red blood cell bag containing a red blood cell preservative solution communicating with the drug solution bag. A blood bag set including a plasma bag that communicates with the red blood cell bag, and a leukocyte removal filter that is provided between the red blood cell bag and the communication path between the blood collection bag and the drug solution bag.

Here, it is preferable that the communication pipe connecting each bag and the filter can be closed by pressure bonding with a clamp, a bent rod or the like or heat welding with a heat sealer. Further, the communication tube may be branched by using a Y-shaped tube, a three-pronged tube, or the like, and the number of blood bags may be appropriately increased by utilizing this.

[0009]

DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention will be described below with reference to the drawings. FIG. 1 is an example of the blood bag set of the present invention.

As shown in FIG. 1, the blood bag set is
A blood collection needle 1 for collecting blood, a blood collection bag 2 containing an anticoagulant, a leukocyte removal filter 7 for removing leukocytes in blood, a red blood cell bag 9 containing a red blood cell preservation solution, and a drug solution. It is composed of a drug solution bag 5 that is temporarily stored, a plasma bag 11 for storing plasma, and communication tubes 3, 4, 6, 8, 10, 12 that aseptically connect these.

Next, each part will be described in more detail with reference to FIG. The leukocyte removal filter 7 is a filter that traps leukocytes in blood but not other blood components, and is made by filling a container such as a hard synthetic resin with a fibrous substance, a porous substance or the like. As the filter material, either a hydrophobic material or a hydrophilic material can be used. The blood collection bag 2, the drug solution bag 5, the red blood cell bag 9, and the plasma bag 11 are all hermetically sealed containers, and a soft synthetic resin is desirable as a forming material. For example, soft vinyl chloride resin, ethylene-vinyl acetate copolymer, polyurethane resin, Examples thereof include polyethylene resin, ethylene-α-olefin copolymer, polyfluorocarbon, polyimide and polyester. And the connecting pipes 3, 4, 6, 8, 10, 12 for aseptically connecting the bags are preferably formed of synthetic resin having a certain degree of transparency and flexibility, for example, vinyl chloride resin, Silicone rubber, polyurethane resin, polyethylene resin, ethylene-vinyl acetate copolymer, ethylene-α-olefin copolymer and the like are adopted. As the blood anticoagulant contained in blood collection bag 2, CPD solution, ACD solution, EDTA solution, heparin, etc. are adopted. As blood preservatives stored in the red blood cell bag 9, mannitol, adenine, sorbitol,
Those containing one or more kinds of guanosine and the like are used.

Next, a method for separating blood components using the blood bag set will be described. Blood collected from the blood collection needle 1 is stored in the blood collection bag 2 containing the anticoagulant via the communication tube 3.
Next, the erythrocyte preservation solution in the erythrocyte bag 9 is passed from the communication tube 8 through the leukocyte removal filter 7, transferred to the drug solution bag 5 via the communication tubes 6 and 4, and then the communication tube 4 is closed by a clamp or the like. At this time, the air in the leukocyte removal filter 7 is exhausted to the drug solution bag 5 together with the red blood cell preservation solution. Then, the blood in the blood collection bag 2 is passed through the communication tubes 4 and 6 through the leukocyte removal filter 7 to remove leukocytes in the blood, and then the communication tube 8
After being accommodated in the red blood cell bag 9, the communication tube 8 is closed with a clamp or the like, and the leukocyte removal filter 7 and the blood bag 2 are separated. Next, the red blood cell bag 9 is subjected to a centrifugal separation process, and then the plasma component in the red blood cell bag 9 is transferred to and stored in the plasma bag 11 via the communication tube 10. Then, the red blood cell preservation solution in the drug solution bag 2 is transferred from the communication pipe 12 to the red blood cell bag 9 to store the red blood cell component in the red blood cell bag 9.

[0013]

According to the present invention, since the red blood cell preservative solution is passed through the white blood cell removal filter 7 in advance to discharge the internal air, there is no risk of air being mixed in when the white blood cells are removed from the blood. The blood component can be preserved under the condition. In addition, since the leukocyte removal filter 7 is separated during the centrifugation, there is no risk of damaging the container of the leukocyte removal filter 7 or the bag containing the blood component during the centrifugation operation. Furthermore, since the whole blood is passed through a leukocyte removal filter and then centrifuged,
It is also possible to effectively prevent side effects due to the incorporation of white blood cells into red blood cell components and plasma components.

[Brief description of drawings]

FIG. 1 is an explanatory diagram of a blood bag set of the present invention.

[Explanation of symbols]

 1 Blood collection needle 2 Blood collection bag 5 Chemical solution bag 7 Leukocyte removal filter 9 Red blood cell bag 11 Plasma bag

Claims (1)

[Claims] 1. A blood collecting bag containing a blood anticoagulant, a drug solution bag communicating with the blood collecting bag, a red blood cell bag containing a red blood cell preservation solution communicating with the drug solution bag, and a red blood cell bag communicating with the red blood cell bag. A blood bag set comprising a plasma bag, a leukocyte removal filter provided between a blood collection bag, a drug solution bag and a red blood cell bag.