JPH0912463A - Orally chewable preparation - Google Patents

Abstract

PURPOSE: To obtain a preparation producible only by mixing crushed powder and/or an extract of a crude medicine with a thicknener and water, obtainable at a low cost, having the crude medicine sterilized through the production, administrable with no water and useful for an old person, a child, etc. CONSTITUTION: This is an orally chewable preparation composed of (A) crushed powder and/or an extract of a crude medicine, (B) a thickener (preferably containing at least gelatin) and (C) water. Examples of the component A are antyusan as a gastrointestinal drug, Japanese angelica peony root powder as a treating agent for oversensitive to the cold, and HATIMIZIOUGANN and NINZINTO (both are specific prescriptions of Chinese medicine) as a nutrition robustness agent. The component A is preferably contained in the preparation at the ratio of 1-70wt.%, preferably 3-60wt.%. The component B is preferably contained in the preparation at 1-15wt.%, preferably 3-10wt.%. Water as the component C is preferably contained at 3-20 times the component B. Further, the preparation is preferably administered at 1-20g/dose, preferably 5-14g/dose 1-3 times a day.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a pulverized powder of crude drug and / or an extract for extraction of a crude drug, a thickening agent and a preparation for oral mastication, which is used in the medical field.

[0002]

2. Description of the Related Art Conventional crude drug preparations are prepared by shredding and crushing the crude drug raw material into powder, or by spray-drying the extract extracted from the crude drug or absorbing it with an appropriate adsorbent to form a powder. Add excipients, disintegrants, etc. to the tablet,
It is processed into dosage forms such as pills and granules.

[0003]

As described above, in the conventional method for producing a herbal medicine preparation, there are many production steps regardless of whether the ground powder raw material or the extracted extract raw material is used, so that the production cost is high and the production is also difficult. There were problems such as a decrease in the content of crude drug components in the process and a risk of contamination by foreign substances. Furthermore, in the case of taking the drug, the conventional formulation is in the form of tablets, pills, granules, etc., which makes it difficult for the elderly and children to take, and even for adults it is difficult to take without water. there were.

[0004]

SUMMARY OF THE INVENTION The inventors of the present invention have
In view of the above problems, as a result of earnest research, as a result of formulating a pulverized powder of crude drug and / or an extract of crude drug by adding a thickener and water, the number of manufacturing steps is small and the cost is low. In addition, it can be produced without impairing the activation of the active ingredient, and the herbicide can be sterilized at the same time in the mixing step with the thickener. Furthermore, this formulation contains sufficient water and has an appropriate gel strength. Therefore, the present invention has been completed and found that it can be swallowed without water because it can be swallowed after chewing in the mouth at the time of taking.

The oral chewing preparation of the present invention is characterized by containing ground powder of crude drug and / or extract of crude drug, thickener and water.

The crude drug used in the oral chewing preparation of the present invention may be a single drug or a mixture of two or more kinds. For example, as a gastrointestinal drug, Anchu-san, etc. As a medicine, such as Toki-Gekiyakusan, as a nutritional tonic, Hachimijiogan, Ginseng-to, Saiko-keishi-to, Shoseiryuto, etc., as a sleep sedative, passionflower, chabotokeisou, etc. The agent includes carrot, the antiallergic agent includes licorice, and the aromatic stomachic agent includes clove.

The pulverized powder of crude drug in the present invention is obtained by shredding and pulverizing the crude drug raw material. The extract of crude drug in the present invention refers to the extract obtained by adding an appropriate leaching agent (for example, water, methanol, ethanol, etc.) to the above crude drug, and concentrating or drying the leachate. The ground powder of crude drug and / or the extract of crude drug is contained in the formulation in a weight ratio of 1 to
70%, preferably 3-60%.

Examples of the thickener used in the oral chewing preparation of the present invention include gelatin, casein, guar gum, locust bean gum, agar, carrageenan, alginic acid, gum arabic, pectin, mannan and xanthan gum. One or two of these thickeners
Although more than one species may be used in combination, it is preferable to use gelatin alone or to use a combination of gelatin and another thickener among these. The thickener is contained in the formulation in a weight ratio of 1 to 15%, preferably 3%.
10% is contained.

The oral chewable preparation of the present invention contains water in order to swell or dissolve the thickener in the preparation to give a gel strength that is easy to chew and swallow. Water is absorbed by the thickener and retained in the formulation. The amount of water required is preferably 3 to 20 times the amount of the thickener used, and when the crude drug extract extract itself has this amount of water, it is not necessary to add more water during production. However, it is necessary to add water at the time of production in the case of ground powder of crude drug, an extract extracted with alcohols or a dry extract, or an extract that is concentrated with a small amount of water even if extracted with water. . The water used is preferably purified water.

The gel strength of the oral chewing preparation which is easy to chew and swallow is as follows. For example, a rheometer is used, a circular flat plate type having a diameter of 10 mm is used as an adapter, and a rising speed of the sample table is 20.
when measured in ^{mm / min, 1~20g / mm 2} , preferably 3~10g / m m ^2.

The oral chewing preparation of the present invention contains a sweetener (eg, sugar, glucose, starch syrup, candy, etc.) for easy administration.
Honey, synthetic sweeteners, etc., moisturizers (eg glycerin, polyethylene glycol etc.), colorants (eg food dyes, natural pigments etc.), flavors (eg orange oil, peppermint oil etc.), animal and vegetable oils (eg orange) It is preferable to add such as oil).
Further, a preservative (eg, ethylparaben, benzoic acid, etc.) and the like may be appropriately added.

The oral chewing preparation of the present invention is obtained by adding water to a thickener and heating it to 70 to 90 ° C. to swell or dissolve it, and mixing the powdered crude drug and / or the extract extracted from the crude drug. Further, the above-mentioned sweeteners, humectants, coloring agents, flavors, animal and vegetable oils, etc. may be appropriately added and mixed, and then the mixture may be filled in a container having a size easy to chew and then cooled, and the like. This formulation is wrapped in aluminum rapig so that water does not evaporate until it is taken.

Since the preparation thus obtained contains a sufficient amount of water and has an appropriate gel strength, it can be taken without water by chewing in the mouth and swallowing. The dose is 1 to 20 g, preferably 5 to 15 g, which is taken 1 to 3 times a day. Furthermore, the gel strength can be freely adjusted by changing the type and amount of the thickener used or the amount of water to be added according to the application, so that it can be used for starch syrup, jelly, nougat, gum, etc. It can be in various dosage forms.

[0014]

EFFECTS OF THE INVENTION The preparation for oral mastication of the present invention can be prepared by simply mixing a pulverized powder of crude drug and / or an extract of crude drug with a thickener and water. In addition, it can be produced without impairing the activity of the active ingredient of the crude drug. Furthermore, since the crude drug can be sterilized at the same time in the process of heating and swelling the thickener, it is possible to prevent accidents such as decay and mold of the crude drug product, which has been conventionally pointed out to be dangerous. Since this preparation can contain a sufficient amount of water, the gel strength can be freely adjusted by changing the type and amount of the thickener used, or the amount of water. Therefore, anyone can take it without water by chewing in the mouth and swallowing, which is particularly useful for the elderly and children, and it is difficult for adults to use water in vehicles such as vehicles while traveling. It is also convenient to take in the place.

[0015]

【Example】

Example 1 Purified water was added to gelatin and locust bean gum and heated at 70 ° C. for 30 minutes to swell. The Hachimi-jio pill extract, glycerin, sugar, preservative and purified water were then combined and added to the swollen thickener. Furthermore, after adding a fragrance | flavor and mixing, it filled in the container and it was made to cool at room temperature, and the preparation for mouth chewing which has the following compositions was obtained.

(Equation 1)

Claims (3)

[Claims] 1. A preparation for oral mastication, which comprises ground powder of crude drug and / or extract of crude drug, thickener and water. 2. The oral chewable preparation according to claim 1, which contains 3 to 20 times as much water as the thickener. 3. The oral chewing preparation according to claim 1, wherein at least gelatin is used as a thickener.