JPH0880291A - Isobaric pack structure of blood collection tube - Google Patents

Abstract

PURPOSE: To provide an isobaric pack structure of blood collection tube capable of keeping a designated reduced pressure condition for a long time without damaging the reduced pressure value of a blood collection tube even if in a drastic usage and storage condition, by composing of a blood collection tube with the inside kept under a reduced pressure condition, and an isobaric container for blood collection tube storage kept under a condition almost equal to the reduced pressure in the blood collection tube. CONSTITUTION: A blocking seal 5 constructed on the opening part of a blood collection tube is air-tightly adhered to a calyx 6 via a adhesive 7. An isobaric container 2a is a bag formed by a laminated sheet 3. The bag is blocked at both ends by an adhesive, etc., and its inside is kept under a reduced pressure condition. The important matter is that the reduced pressure in the isobaric container 2a is set at almost equal to that of the blood collection tube 1. The laminated sheet 3 composing the isobaric container 2a is a laminated material constituted by metal foil 3b with no pinhole for the middle layer and resin films 3a on the both side of the metal foil.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a constant pressure pack structure capable of reliably maintaining a reduced pressure value required for a blood collection tube for a long period of time even under severe conditions.

[0002]

2. Description of the Related Art In recent years, various medical and medical examinations have been started.
When performing the check, blood tests are commonly performed. Recently, as a method of performing a blood test, it is general to use a blood collecting device (12) equipped with an injection needle (13) as shown in FIG. That is, the injection needle (13) is inserted into a patient's vein, and then the blood collection tube (1) whose inside is kept in a constant depressurized state is inserted up to the step (15) of the blood collecting device (13). Then
The back end of the injection needle (13) is the thin-walled part (8) of the heso rubber (8) of the blood collection tube (1).
The b) is pierced to reach the inside of the blood collection tube (1), and venous blood is sucked into the blood collection tube (1) due to the decompression effect in the blood collection tube (1). According to this, it is possible to perform a plurality of blood collection operations only by exchanging the blood collection tube (1), which not only reduces the pain of the nurse but also significantly reduces the blood collection work of the nurse. is there.

[0003] In the above-mentioned blood collection work, it is necessary to accurately perform one blood collection so that the subsequent blood test can be performed accurately. Therefore, the blood collection tube (1) is prepared so as to be kept in a constant depressurized state so that a predetermined amount of blood can be collected. When the decompression value decreases, the suction capacity of the blood collection tube (1) decreases and it becomes impossible to collect a predetermined amount of blood. Currently, it is not limited to this.
For milliliters, it is set to 430 torr + 50 torr.

A blood collection tube (1 ') used for such blood collection has a structure as shown in FIG.
Chamber maintained at 0 Torr vacuum (not shown)
It is manufactured by attaching a stopper or a closing seal (5 ') inside. The opening of the blood collection tube (1 ') is sealed almost completely in an airtight state by the rubber stopper or the closing seal (5'), which keeps the inside of the blood collection tube (1 ') at a reduced pressure value of about 430 Torr. Will be done. A heso rubber (8 ') for piercing the injection needle (13') of the blood collecting device (12 ') is adhered to the center of the closing seal (5').

The blood collection tube (1) generally has a certain time lag between its manufacture and its use. Therefore, the blood collection tube (1)
The depressurization value of should be maintained at a value of approximately 430 torr. Therefore, a gas barrier PET (polyethylene terephthalate resin) or glass is used as the blood collection tube (1) so that the air does not permeate into the inside of the blood collection tube (1). The rubber plug has a large thickness (for example, 6.5 mm) to suppress gas permeation, but this increases the resistance to needle stick and the burden on the nurse. Further, for the closing seal (5), a relatively thick aluminum foil without pinholes is used, and care is taken to prevent air from entering through the closing seal (5). However, the blood collection tube (1) and the occlusion seal (5) are very small because they are connected by the adhesive (7), but the interface of the adhesive (7) or the adhesive (7) There is a problem that outside air enters into the blood collection tube (1) through the air passage and gradually decreases the decompression value in the blood collection tube (1) in combination with gas permeation from the plastic tube.

[0006] Further, the use environment of the blood collection tube (1) is not always stored in an ideal environment such as a temperature-controlled room, and is not always used in a well-equipped hospital, but in a tropical region or cold climate. In many cases, it is often transferred to a very harsh environment such as the desert region where the difference in temperature between day and night is large, and it is also used.
In such a case, it is often stored in a very poorly stored place or transported under severe conditions, and at such a place of use or a transportation route, gas permeation from the rubber plug becomes large, or As the adhesive (7) deteriorates, the usable life will be shortened significantly.

[0007] Therefore, the period of use of the blood collection tube (1) has been determined, and if the blood collection tube (1) has passed this time, the internal decompression value will be incorrect and it will be unusable, and it will be discarded. is the current situation. Further, as shown in FIG. 7, when the blood collection tube (1) is exposed to the atmosphere, atmospheric pressure is constantly applied to the closing seal (5), so the closing seal (5) is pushed to the atmospheric pressure. It is pushed inward from the opening of the blood collection tube (1), and shearing force is always applied to the adhesive (7). This also causes the adhesive (7) to deteriorate when a long time has passed, and also contributes to a reduction in the ability of the blood collection tube (1) to hold the reduced pressure state.

As mentioned above, if the blood collection tube (1) is made of a gas barrier material, it will be more expensive than a low gas barrier material, and it is a problem that a disposable material cannot be overlooked economically. .

[0009]

The object of the present invention is to maintain a predetermined depressurized state for a drastically long period of time without damaging the depressurized value of the blood collection tube even under severe usage and storage conditions. It is to be able to do it, and to be able to change the material of the blood collection tube to the cheap one.

[0010]

The isobaric pack structure of the blood collection tube (1) according to claim 1 of the present invention is "a blood collection tube (1) whose inside is held in a reduced pressure state, and a blood collection tube (1)". It is characterized in that it is composed of a constant-pressure container (2) for storing a blood collection tube which is maintained in a reduced pressure state substantially equal to the reduced pressure value inside.

As a result, unless the isobar (2) is damaged, the pressure inside and outside the blood collection tube (1) is balanced and the open end of the blood collection tube (1) is closed with an adhesive (7). If pressure is not applied to (5), the adhesive layer where outside air can easily enter
Air does not enter the blood collection tube (1) from (7), and the decompression value in the isobar (2) does not decrease even under severe storage and use conditions. The period of use of the blood vessel (1) can be dramatically lengthened.

[0012] Claim 2 is characterized in that "the isobar (2) is composed of a gas barrier member", and claim 3 is that "the blood collection tube (1) is a low gas barrier member". It is characterized in that it is configured, and the predetermined decompression value is maintained for a long time in the gas barrier isobar (2), so the material of the blood collection tube (1) is not necessarily a gas barrier material. There is no need, and low gas barrier materials can also be used, which can significantly reduce the manufacturing cost.

[0013]

The present invention will be described below with reference to the illustrated embodiments. FIG. 1 is a sectional view of a first embodiment of the isobaric pack structure according to the present invention, showing a state in which a blood collection tube (1) is housed in an isobaric container (2a) of the first embodiment. The blood collection tube (1) is airtightly attached to the collar (6) provided at the open end of the blood collection tube (5) via the adhesive (7). For example, the inside of the blood collection tube (1) having a blood collection amount of 5 milliliters is maintained at a reduced pressure of about 430 torr, and the error is about + 10% (+50 torr).

A round soft heso rubber (8) is attached to the center of the closing seal (5). A concave portion (8a) is concentrically formed in the center of the bellows rubber (8), and the bottom portion of the concave portion (8a) has a thin portion (8a).
b).

In the first embodiment, the isobar (2a) is a bag formed of a laminate sheet (3) as shown in FIG.
Both ends thereof are closed with an adhesive and the inside is kept in a reduced pressure state. What is important here is the isobar (2a).
The degree of decompression inside is almost the same as that of the blood collection tube (1) 4
It is set to 30 torr (torr) + 50 torr (torr).

As shown in FIG. 3, the laminated sheet (3) constituting the isobar (2a) has a metal foil (3b) without a pinhole at the center (for example, aluminum foil is generally used, Here, an aluminum foil will be described as a typical example of the metal foil (3b). }, And a resin film (3a) (for example, a polypropylene film having a thickness of, for example, about 20 μm) laminated on both sides thereof.
The thickness of the aluminum foil (3b) is such that pinholes do not occur (for example, 8 μm or more, 12 μm
If it is above, there is no pinhole and airtightness is not impaired, so it is safe. ) Is selected. The thickness of the laminated sheet isobar (2a) is not particularly limited, but the required performance is that it does not break during depressurization work and storage, and that airtightness is maintained almost completely for a long period of time. Things are needed. Further, when such a laminate material is used as the isobar (2), the surroundings of the isobar (2a) will adhere due to atmospheric pressure as shown in FIG. A space (4) remains in the surroundings, and that part
(4) will be set to the above-mentioned reduced pressure value.

For example, a V-shaped notch (9) is provided at the end of the isobaric container (2a) so that the isobaric container (2a) can be easily broken from the notch (9) when used. Further, in the embodiment of FIG. 1, an example in which one blood collection tube (1) is housed in the isobaric container (2a) is shown, but the present invention is not limited to this, and a plurality of blood collection tubes (1) are arranged side by side in the isobaric container. It can also be stored in (2a).

FIG. 4 shows a laminated sheet isobar (2
FIG. 3 is a cross-sectional view of a case where a blood collection tube (1) having a rubber stopper (5a) plugged therein is housed in a). Center of outer surface of rubber stopper (5a) and blood collection tube (1)
There are recesses (5b) and (5c) on the inside of the rubber stopper (5a).
The thickness of the central part of the is thin so that the injection needle (13) can be inserted easily.

FIG. 5 is a sectional view of the second embodiment of the present invention, which is an example in which a tubular isobar (2b) is used instead of the laminated sheet isobar (2a). In this case, for the tube-shaped isobar (2b), for example, PET having a gas barrier property is used. An external blocking sheet (10) is attached to the opening of the tubular isobar (2b) via an adhesive (11), and the inside is kept airtight at a reduced pressure value almost the same as that of the blood collection tube (1). I am supposed to keep it. When used, the external blocking sheet (10) may be peeled off. Also in this case, the space (4) is set to the same reduced pressure value as the blood collection tube (1). A rubber plug (not shown) for external closing may be used instead of the external closing sheet (10).

Also in the case of the second embodiment, FIG. 5 shows only an example in which one blood collection tube (1) is housed, but of course the invention is not limited to this, and the isobaric container (2b) is made larger and a plurality of tubes are provided. The blood collection tube (1) may be stored.

As described above, since the blood collection tube (1) is kept in the depressurized state substantially equal to the depressurized value in the blood collection tube (1) and is housed in the isobar (2), the isobar ( Unless the reduced pressure in 2) is broken, the reduced pressure inside the blood collection tube (1) will not decrease for a long period of time. Therefore, blood collection tubes can be used even in very bad environments.
The depressurized state of (1) is not impaired and it can be used with confidence. Further, even if the decompression value of the isobar (2) is reduced, the influence on the blood collection tube (1) is still small compared to the atmosphere, and in this respect as well, the period of use of the blood collection tube (1) is greatly extended. It is something that can be done. FIG. 8 shows the deterioration of the degree of vacuum of the blood collection tube (1 ') using a conventional rubber stopper without the equal pressure pack and the blood collection tube (1) for storing the equal pressure pack according to the present invention with time and temperature. Compared to. The horizontal axis represents time and the vertical axis represents the degree of vacuum reduction. According to this, the product of the present invention (indicated by a line connecting ⋄) did not show a decrease in the degree of vacuum in the blood collection tube (1) even if it was kept at 43.5 ° C for 24 months. , The conventional product shown as a comparative example is
When kept at 23.5 ° C (indicated by a line connecting □), the degree of vacuum was reduced by about 0.5 mmHg at 24 months, and when kept at 43.5 ° C ( + Is shown by a line connecting them.), And the vacuum degree is decreased by about 3.3 mmHg at 24 months. As a result, the product of the present invention does not show a decrease in the vacuum degree of the blood collection tube (1) even when it is held at 43.5 ° C. where the conditions are bad. I understand that.

The examples of the isobaric container (2) having a laminate / pack structure and a tube form have been shown, but of course, the present invention is not limited to this, and one to many blood collection tubes (1) can be stored. , A container or a bag capable of maintaining a reduced pressure value in the isobaric container (2) at the same reduced pressure value as the blood collection tube (1) for a long period of time is the equal pressure container (2 ) Will be included in the concept.

Further, in the case of the conventional example, the blood collection tube (1) is
Although it must be composed of a gas-barrier resin or glass tube, in the present invention, a blood collection tube (1) is provided by an isobar (2).
Since the depressurized value in the inside will not be impaired for a long period of time, it is not necessary to use gas barrier resin or glass as the material of the blood collection tube (1) like the conventional example if it is used within a short period after opening. It is possible to use a material with a low gas barrier property, which results in a significant cost reduction.

The isobaric container (2) is preferably a gas barrier material, but it is not required to be a perfect material, and a gas barrier material may be used as long as it is capable of suppressing the decrease in decompression value for a certain period of time. It is not limited.

[0025]

Industrial Applicability According to the present invention, a blood collection tube whose inside is kept in a decompressed state is housed in a constant pressure container for storing a blood collection tube which is kept in a decompressed state substantially equal to the decompressed value in the blood collection tube. Therefore, as long as the isobar is not damaged, the decompression value of the blood collection tube can be maintained for a long period of time even under severe storage conditions. Since it is retained for a long time, it is not necessary to use an expensive gas barrier material as the material of the blood collection tube, and it is possible to use a non-gas barrier material, which can significantly reduce the manufacturing cost. There are also advantages.

[Brief description of drawings]

FIG. 1 is a sectional view of a first embodiment of the present invention.

FIG. 2 is a sectional view taken along line XX of FIG.

FIG. 3 is an enlarged sectional view of a laminate film used in the present invention.

FIG. 4 is a sectional view of another example of the first embodiment of the present invention.

FIG. 5 is a sectional view of a second embodiment of the present invention.

FIG. 6 is a cross-sectional view when a blood collection tube is attached to a blood collection device.

FIG. 7 is a sectional view of a conventional blood collection tube.

FIG. 8 is a graph showing the influence of temperature on the degree of vacuum between the conventional example and the product of the present invention over time.

[Explanation of symbols]

 (1)… Blood collection tube (2)… Isobaric container for storing blood collection tube

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Hiroshi Sato 348 Showa Rubber Co., Ltd., Kashiwa City, Chiba Prefecture (72) Inventor Masami Kono 348 Showa Rubber Co., Ltd., Kashiwa City, Chiba Prefecture (72) Inventor Takuya Suzuki 348 Showa Rubber Co., Ltd.

Claims (5)

[Claims] 1. A blood sampling tube whose inside is held in a depressurized state, and an isobar container for storing a blood sampling tube which is held in a depressurized state substantially equal to the depressurized value in the blood sampling tube. Isobaric pack structure of blood vessels. 2. The isobaric pack structure for a blood collection tube according to claim 1, wherein the isobaric container is composed of a gas barrier member. 3. The isobaric pack structure for a blood collection tube according to claim 1, wherein the blood collection tube is formed of a low gas barrier member. 4. The isobaric pack structure for a blood collection tube according to claim 2, wherein the gas barrier member is a sheet in which a resin film is laminated on both surfaces of a metal foil. 5. The isobaric pack structure for a blood collection tube according to claim 2, wherein the gas barrier member is a multilayer barrier film.