JPH08319232A - Particulate composition - Google Patents

Abstract

PURPOSE: To obtain a stabilized particulate composition containing a vitamin, especially an easily oxidizable lipo-soluble vitamin. CONSTITUTION: A particulate composition is obtained by compounding 0.1-20wt.% of a gallic acid, 5-30wt.% of whey or coffee, 10-50wt.% of a vitamin, 10-50wt.% of gelatin and further water, forming the obtained emulsive suspension into gelatin beads, and subsequently heating the gelatin beads preferably at 130-180 deg.C. The water is used in a weight amount of 4-8 times that of the gelatin, and the water content in the composition obtained by the thermal evaporation of the gelatin beads is preferably >=5wt.%. The vitamin is preferably vitamin A acetate, and the whey is α-lactalbumin originated from the milk of a cow, etc. The gelatin includes a gelatin treated with lime (alkali) containing bovine bone cortex as the main component.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a granular composition, and more particularly to a stabilized composition containing vitamins.

[0002]

BACKGROUND OF THE INVENTION Vitamins, especially fat-soluble vitamins, are mixed with gelatin, acacia gum, sugars, starches, antioxidants, etc., emulsified and beaded by various production methods to be widely used in the fields of medicine, food, feed, etc. It is used. However, in many of the fat-soluble vitamin-containing beads, the coating agent is gelatin, acacia gum, etc. during storage, so that gelatin, acacia gum, etc. swell, and then the fat-soluble vitamin beads in the gelatin beads are disintegrated, dissolved, or cracked. Due to the elution, oozing and leakage of vitamins, the fat-soluble vitamin activity is significantly decomposed, and stabilization of the fat-soluble vitamin activity is a problem. Therefore, there is a demand for a pharmaceutical composition having a high stability of fat-soluble vitamin activity even under the severe conditions as described above, and various attempts have been made to improve the composition, the pharmaceutical preparation, the production method and the like.

For example, an aqueous emulsion suspension having a composition containing gelatin, water and sugar is formed in a fat-soluble vitamin active substance, and this emulsion is dried particles containing a non-aqueous constituent of the emulsion. A stabilized composition and production method of fat-soluble vitamins are known, in which the product is converted into a shape product, and the resulting product is heat-treated to form water-insoluble small beads (JP-A-63-63).
258807). The obtained water-insoluble beadlets are said to have the active substance stabilized in the pelletizing step even under high temperature and high humidity around 100 ° C. Further, in JP-A-5-32941, in producing a composition containing vitamin A, gelatin, water, sugar, a water-soluble salt of a carboxylic acid and additional components, particularly an emulsion suspension of vitamin A, are used. The product obtained is heat treated at 100 ° C. while maintaining the water content at a level of about 3% by weight.
The water-insoluble beadlets are formed in the water for at least 3 minutes to stabilize the active substance.

[0004]

DISCLOSURE OF THE INVENTION The present invention provides a composition containing vitamins, particularly fat-soluble vitamin active substances, which are sufficiently stable during storage, and in particular, fat-soluble vitamin active substances, gallic acids and whey. Alternatively, it is intended to provide a powdery and granular composition obtained by heating gelatin beads consisting of at least one kind of coffee, gelatin, and water, particularly stabilized gelatin beads containing a fat-soluble vitamin active substance. To do. There is no prior art mentioning the use of gallic acids, whey, coffee. That is, the composition of the present invention is different from the above known composition.

[0005]

Means for Solving the Problems The present inventors have earnestly studied to obtain a composition containing vitamins, especially fat-soluble vitamins, which are stable even under high temperature and high humidity. A composition containing gelatin and water as active substances and at least one of gallic acid, whey and coffee after emulsification, followed by drying, and heat treatment of the resulting gelatin beads to obtain a composition having extremely excellent stability. Based on this finding, further research was conducted and the present invention was completed. That is, the present invention

(1) A powdery or granular composition containing at least one of gallic acid, whey or coffee, vitamins and gelatin, and (2) a stabilized powdery or granular composition (1). ), (3) the vitamins are fat-soluble vitamins, the composition of (1), and (4) the fat-soluble vitamins are vitamin A, the composition of (3).

The present invention also provides (5) a powdery and granular composition characterized in that gelatin beads containing at least one of gallic acid, whey or coffee, vitamins, gelatin and water are subjected to heat treatment. Manufacturing method, especially
(6) The heating temperature is about 130 to 180 ° C (5)
The manufacturing method of is also provided.

[0008]

BEST MODE FOR CARRYING OUT THE INVENTION Examples of vitamins used in the composition of the present invention include vitamins commonly used in medicine, food, feed, agricultural chemicals, and the like, such as fat-soluble vitamins and water-soluble vitamins. The present invention is particularly effective for compounds that are easily oxidized such as fat-soluble vitamins. Fat-soluble vitamins are vitamin-producing oils, provitamins and pure or substantially pure vitamins, both natural and synthetic, or their chemical derivatives and mixtures thereof. Among these, for example, vitamin A active substances are mentioned, and examples thereof include vitamin A acetate, vitamin A palmitate and the like (these may be collectively referred to as vitamin A) and vitamins D, E and K. Also, carotenoids such as β-carotene,
One or more kinds selected from the group consisting of astaxanthin and canthaxanthin are fat-soluble vitamins.
Examples of water-soluble vitamins include vitamin B ₁ and
Riboflavin, vitamin B ₆ , nicotinic acid, pantothenic acid, biotin, folic acid, vitamin B ₁₂ , ascorbic acid,
Examples thereof include lipoic acid and inositol. The blending amount of vitamins in the composition of the present invention can be appropriately selected depending on the type of individual vitamin to be used, but usually about 10 to 50% by weight is blended based on the total weight of the composition.

Examples of gallic acids used include gallic acid and its esters. Gallic acid is the leaf of plants,
It is obtained by hydrolyzing tannic acid derived from natural products such as stems and roots, and for example, trade name, "gallic acid" by Dainippon Pharmaceutical Co., Ltd., etc. can be used. It also includes gallic acid, 3,4,5-trioxybenzoic acid and the like. Examples of the ester include propyl gallate, ethyl, isoamyl ester and the like.

As whey, those derived from milk such as cow, goat, sheep, etc., such as cheese whey, concentrated whey,
The proteins in these components (eg, α-lactalbumin, β-lactoglogrin, etc.) can be mentioned. These are also powder-dried ones. For example, whey protein is preferably prepared as a concentrate (WPC) and powdered. As an example, the product name "GL manufactured by MEGGLE"
OBULAL 80HGS "can be used.

Examples of coffee include coffee bean extract, ground coffee bean, and processed products thereof. For example, commercially available instant coffee can be used.

These gallic acids, whey and coffee may be used alone or in combination of two or more at an appropriate ratio,
Usually, gallic acids are about 0. 0 based on the total weight of the composition.
1 to 20% by weight, whey is blended in about 5 to 30% by weight, and coffee is blended in about 5 to 30% by weight.

The gelatin used may be either of the A-type acid treatment method containing pig skin as the main component and the B-type lime (alkali) treatment method containing pig bone skin as the main component. The physical properties of gelatin are generally bloom.
This is a unit for expressing jelly strength. The gelatin used in the present invention has a bloom of about 100 to 30.
0 is good. The B type of the lime (alkali) treatment method is preferable. The jelly strength is preferably about 300 Bloom. For example, product name "# 300" manufactured by Nitta Gelatin Co., Ltd., product name "E-290" manufactured by Miyagi Chemical Co., Ltd.
Etc. are good. Gelatin is usually used in a proportion of about 10 to 50% by weight, based on the total weight of the composition.

The composition of the present invention is prepared by a method known per se from an emulsified suspension containing at least one of gallic acid, whey or coffee, vitamins, seratin and water.
It can be produced by granulating by a known method to obtain gelatin beads, which are preferably heat-treated in the range of about 130 ° C to 180 ° C, more preferably in the range of about 130 ° C to 150 ° C. Water is based on the weight of gelatin used,
It is used in a weight ratio of about 4 to 8 times, but it is evaporated by heat treatment, and the content in the obtained composition is usually about 10% by weight or less, and the water content of the composition is about 5% by weight. The following are preferred. If desired, gelatin beads may be prepared by further adding additives such as starches (eg, corn starch, potato starch, wheat starch, tapioca starch, rice starch, etc.), silicon dioxide, hydrophobic silicon dioxide, etc. Good. Of these, starches are preferably used. The composition of the present invention thus obtained is in the form of beads, but it may be in the form of powder particles such as columnar, angular and elliptical shapes. It may also be an aggregate of beads. The powdery or granular composition of the present invention can be used as a medicine, food, feed or the like.

[0015]

EXAMPLES The present invention will be described in more detail below with reference to Examples, Comparative Examples and Test Examples, but the present invention is not limited to these Examples. Example 1 Vitamin A acetate crystallinity (BASF Japan Ltd.)
Was melted at 65 ° C. in advance, and 26.5 parts by weight and 13.2 parts by weight of ethoxyquin were mixed after melting. To 220 parts by weight of distilled water preheated to 65 ° C, 45.4 parts by weight of gelatin (B type, jelly strength of 300 bloom), 14.8 parts by weight of glycerin and 5.0 parts by weight of gallic acid were added and sufficiently dispersed. The mixture was homogenized until it was sufficiently dispersed. Gelatin beads were obtained from this emulsified suspension by a known spray granulation method using cornstarch (trade name "cornstarch ST-C", Nitto Kagaku KK). 15 Gelatin beads in an electric oven at a set temperature of 150 ° C
Heated for minutes. The gelatin beads thus obtained had a vitamin A activity of 500,000 IU / g.

Example 2 An emulsified suspension having the same composition as the emulsified suspension of Example 1 was prepared, and gelatin beads were obtained by the method of Example 1.
The gelatin beads were heated in an electric oven at a set temperature of 130 ° C for 30 minutes. The gelatin beads thus obtained had a vitamin A activity of 550,000 IU / g. g Vitamin A acetate, crystalline, 2,800,000 IU / g 26.50 ethoxyquin 13.20 gallic acid 7.50 glycerin 14.80 gelatin (B type, 300 bloom) 45.40 distilled water 250.00

Example 3 Instead of the emulsion suspension of Example 1, an emulsion suspension having the following composition was prepared, and gelatin beads were obtained by the method of Example 1. The gelatin beads were heated in an electric oven at a set temperature of 150 ° C for 15 minutes. The gelatin beads thus obtained had a vitamin A activity of 330,000 IU / g. g Vitamin A palmitate crystalline, 1,700,000 IU / g 26.50 ethoxyquin 13.20 gallic acid 10.20 glycerin 14.80 gelatin (B type, 300 bloom) 45.40 distilled water 220.00

Example 4 Instead of the emulsified suspension of Example 1, an emulsified suspension having the following composition was prepared and gelatin beads were obtained by the method of Example 1. The gelatin beads were heated in an electric oven at a set temperature of 150 ° C for 15 minutes. The gelatin beads thus obtained had a vitamin A activity of 530,000 IU / g. g Vitamin A acetate, crystalline, 2.8 million IU / g 26.50 ethoxyquin 13.20 gallic acid 10.00 glycerin 14.80 gelatin (B type, 200 bloom) 50.00 distilled water 230.00

Example 5 Instead of the emulsified suspension of Example 1, an emulsified suspension having the following composition was prepared and gelatin beads were obtained by the method of Example 1. The gelatin beads were heated in an electric oven at a set temperature of 150 ° C for 15 minutes. The gelatin beads thus obtained had a vitamin A activity of 530,000 IU / g. g Vitamin A acetate, crystalline, 2,800,000 IU / g 26.50 ethoxyquin 13.20 gallic acid 15.00 glycerin 14.80 gelatin (type B, 100 bloom) 55.00 distilled water 240.00

Example 6 Instead of the emulsion suspension of Example 1, an emulsion suspension having the following composition was prepared, and gelatin beads were obtained by the method of Example 1. The gelatin beads were heated in an electric oven at a set temperature of 150 ° C for 15 minutes. The gelatin beads thus obtained had a vitamin A activity of 530,000 IU / g. g Vitamin A acetate, crystalline, 2.8 million IU / g 26.50 ethoxyquin 13.20 propyl gallate 0.130 glycerin 14.80 gelatin (type A, 300 bloom) 45.40 distilled water 220.00

Example 7 Instead of the emulsified suspension of Example 1, an emulsified suspension having the following composition was prepared and gelatin beads were obtained by the method of Example 1. The gelatin beads were heated in an electric oven at a set temperature of 150 ° C for 15 minutes. The gelatin beads thus obtained had 10% folic acid. g Folic acid 12.00 Gallic acid 5.00 Glycerin 10.00 Gelatin (type A, 300 bloom) 31.00 Distilled water 220.00

Example 8 Instead of the emulsified suspension of Example 1, an emulsified suspension having the following composition was prepared and gelatin beads were obtained by the method of Example 1. The gelatin beads were heated in an electric oven at a set temperature of 150 ° C for 15 minutes. The gelatin beads thus obtained had 51.1% vitamin E. g dl-α-tocopherol 50.00 Gallic acid 5.00 Glycerin 10.00 Gelatin (B type, 300 bloom) 30.00 Distilled water 220.00

Comparative Example 1 An emulsion suspension was prepared by removing gallic acid or esterified from the composition of Example 1 and gelatin beads were obtained by the method of Example 1. Gelatin beads set temperature 1
Heat in an electric oven at 50 ° C. for 15 minutes. The gelatin beads thus obtained have a vitamin A activity of 500,00.
It had 0 IU / g.

Comparative Example 2 An emulsified suspension similar to that of Example 1 was prepared, and gelatin beads were obtained by the method of Example 1. The gelatin beads were heated in an electric oven at a set temperature of 100 ° C for 15 minutes. The gelatin beads thus obtained have a vitamin A activity of 54.
It had 000 IU / g.

Comparative Example 3 Vitamin A acetate crystallinity was melted at 65 ° C. in advance, and 26.5 parts by weight and 13.25 parts by weight of ethoxyquin were mixed after melting. Further, to 220 parts by weight of distilled water heated in advance to 65 ° C., an emulsion suspension of 45.4 parts by weight of gum arabic, 14.8 parts by weight of glycerin and 8 parts by weight of lactose was adjusted to a sufficient concentration for spraying, The gum arabic beads obtained by the method of Example 1 were heated for 15 minutes in an electric oven at a set temperature of 150 ° C. The gum arabic beads thus obtained have a vitamin A activity of 480,000.
It had an IU / g. Table 1 shows the main compositions and heating temperatures of Examples 1 to 8 and Comparative Examples 1 to 3 described above.

[0026]

[Table 1]

Test Example 1 The fat-soluble vitamin-containing beads obtained in Examples 1 to 8 and Comparative Examples 1 to 3 were subjected to a storage test. The test method is as follows: A white bottle (PS-6K, manufactured by Daiichi Glass Co., Ltd.) is weighed with about 50 g of fat-soluble vitamin-containing gelatin beads, the lid is opened, and 40
The mixture was placed in a desiccator under the condition of RH of 53% and the light was blocked to measure the residual rate of the active substance in the fat-soluble vitamin-containing beads after storage for 3 months. Table 2 shows the results.

[0028]

[Table 2]

Example 9 Vitamin A acetate crystallinity (BASF Japan Ltd.)
Was melted at 65 ° C. in advance, and after melting, 30.0 parts by weight and 15.0 parts by weight of ethoxyquin were mixed. In addition, 220 parts by weight of distilled water preheated to 65 ° C., 40.0 parts by weight of gelatin (B type, jelly strength of 300 bloom) and 14.0 parts by weight of glycerin, 22.0 parts by weight of whey powder, 10.0 parts of lactose. Parts by weight were added and sufficiently dispersed, and the mixture was homogenized until sufficiently dispersed. This emulsified suspension is cornstarch (trade name "cornstarch ST
Gelatin beads were obtained by a known spray granulation method using "-C", manufactured by Nitto Chemical Co., Ltd. The gelatin beads were heated in an electric oven at a set temperature of 150 ° C for 15 minutes. The gelatin beads thus obtained have a vitamin A activity of 506,
It had 000 IU / g.

Example 10 An emulsion suspension having the same composition as the emulsion suspension of Example 9 was prepared, and gelatin beads were obtained by the method of Example 9.
The gelatin beads were heated in an electric oven at a set temperature of 130 ° C for 30 minutes. The gelatin beads thus obtained had a vitamin A activity of 520,000 IU / g. g Vitamin A acetate, crystalline, 2.8 million IU / g 30.00 ethoxyquin 15.00 whey powder 15.00 lactose 10.00 glycerin 14.80 gelatin (B type, 300 bloom) 40.00 distilled water 220 .00

Example 11 Instead of the emulsion suspension of Example 9, an emulsion suspension having the following composition was prepared, and gelatin beads were obtained by the method of Example 9. The gelatin beads were heated in an electric oven at a set temperature of 150 ° C for 15 minutes. The gelatin beads thus obtained had a vitamin A activity of 310,000 IU / g. g Vitamin A palmitate crystalline, 1,700,000 IU / g 26.50 ethoxyquin 13.20 whey powder 10.00 lactose 10.00 glycerin 14.80 gelatin (B type, 300 bloom) 40.00 distilled water 220. 00

Example 12 Instead of the emulsion suspension of Example 9, an emulsion suspension having the following composition was prepared, and gelatin beads were obtained by the method of Example 9. The gelatin beads were heated in an electric oven at a set temperature of 150 ° C for 15 minutes. The gelatin beads thus obtained had a vitamin A activity of 530,000 IU / g. g Vitamin A acetate, crystalline, 2,800,000 IU / g 30.00 Ethoxyquin 15.00 Whey powder 10.00 Lactose 10.00 Glycerin 14.80 Gelatin (B type, 200 Bloom) 50.00 Distilled water 230 .00

Example 13 Instead of the emulsion suspension of Example 9, an emulsion suspension having the following composition was prepared, and gelatin beads were obtained by the method of Example 9. The gelatin beads were heated in an electric oven at a set temperature of 150 ° C for 15 minutes. The gelatin beads thus obtained had a vitamin A activity of 530,000 IU / g. g Vitamin A acetate, crystalline, 2.8 million IU / g 30.00 ethoxyquin 15.00 whey powder 15.00 lactose 10.00 glycerin 14.80 gelatin (type B, 100 bloom) 55.00 distilled water 240 .00

Example 14 Instead of the emulsion suspension of Example 9, an emulsion suspension having the following composition was prepared, and gelatin beads were obtained by the method of Example 9. The gelatin beads were heated in an electric oven at a set temperature of 150 ° C for 15 minutes. The gelatin beads thus obtained had 10% folic acid. g Folic acid 12.00 Whey powder 5.00 Glycerin 10.00 Gelatin (type A, 300 bloom) 31.00 Distilled water 220.00

Example 15 Instead of the emulsion suspension of Example 9, an emulsion suspension having the following composition was prepared and gelatin beads were obtained by the method of Example 9. The gelatin beads were heated in an electric oven at a set temperature of 150 ° C for 15 minutes. The gelatin beads thus obtained had 50.6% vitamin E. g dl-α-tocopherol 50.00 Whey powder 5.00 Lactose 2.00 Glycerin 10.00 Gelatin (B type, 300 bloom) 30.00 Distilled water 220.00

Comparative Example 4 An emulsified suspension in which whey powder was omitted from the composition of Example 9 was prepared, and gelatin beads were obtained by the method of Example 9. Place gelatin beads in an electric oven at a set temperature of 150 ° C 1
Heated for 5 minutes. The gelatin beads thus obtained had a vitamin A activity of 503,000 IU / g.

Comparative Example 5 An emulsified suspension similar to that of Example 9 was prepared, and gelatin beads were obtained by the method of Example 9. The gelatin beads were heated in an electric oven at a set temperature of 100 ° C for 15 minutes. The gelatin beads thus obtained have a vitamin A activity of 53.
It had 5,000 IU / g.

Comparative Example 6 Vitamin A acetate crystallinity was melted at 65 ° C. in advance, and 26.5 parts by weight and 13.25 parts by weight of ethoxyquin were mixed after melting. Further, to 220 parts by weight of distilled water heated in advance to 65 ° C., an emulsion suspension of 45.4 parts by weight of gum arabic, 14.8 parts by weight of glycerin and 8 parts by weight of lactose was adjusted to a sufficient concentration for spraying, The gum arabic beads obtained by the method of Example 9 were heated in an electric oven at a set temperature of 150 ° C. for 15 minutes. The gum arabic beads thus obtained have a vitamin A activity of 480,000.
It had an IU / g. Table 3 summarizes the main compositions and heating temperatures of Examples 9 to 14 and Comparative Examples 4 to 6 described above.

[0039]

[Table 3]

Test Example 2 The fat-soluble vitamin-containing beads obtained in Examples 9 to 14 and Comparative Examples 4 to 6 were subjected to a storage test. The test method is as follows: About 50 g of fat-soluble vitamin-containing gelatin beads is weighed into a white bottle (PS-6K, manufactured by Daiichi Glass Co., Ltd.), the lid is opened, and 60
The mixture was placed in a desiccator under the condition of RH of 53% at ℃, the light was blocked, and the residual ratio of the active substance in the fat-soluble vitamin-containing beads after one month storage was measured. The results are shown in Table 4.

[0041]

[Table 4]

Example 16 Vitamin A acetate crystallinity (BASF Japan Ltd.)
Was melted at 65 ° C. in advance, and after melting, 30.0 parts by weight and 15.0 parts by weight of ethoxyquin were mixed. Also, to 220 parts by weight of distilled water heated in advance to 65 ° C., 40.0 parts by weight of gelatin (B type, jelly strength of 300 bloom), 14.0 parts by weight of glycerin and 10.0 parts by weight of coffee powder were added and sufficiently dispersed. The mixture was homogenized until it was sufficiently dispersed. This emulsified suspension is cornstarch (trade name "cornstarch ST-C", manufactured by Nippon Starch Co., Ltd.)
Gelatin beads were obtained by a known spray granulation method using.
The gelatin beads were heated in an electric oven at a set temperature of 150 ° C for 15 minutes. The gelatin beads thus obtained had a vitamin A activity of 500,000 IU / g.

Example 17 An emulsified suspension having the following composition similar to that of Example 16 was prepared, and gelatin beads were obtained by the method of Example 16. The gelatin beads were heated in an electric oven at a set temperature of 130 ° C for 30 minutes. The gelatin beads thus obtained had a vitamin A activity of 450,000 IU / g. g Vitamin A acetate, crystalline, 2.8 million IU / g 30.00 ethoxyquin 15.00 coffee powder 22.00 glycerin 14.80 gelatin (B type, 300 bloom) 40.00 distilled water 220.00

Example 18 Instead of the emulsion suspension of Example 16, an emulsion suspension having the following composition was prepared, and gelatin beads were obtained by the method of Example 16. The gelatin beads were heated in an electric oven at a set temperature of 150 ° C for 15 minutes. The gelatin beads thus obtained had a vitamin A activity of 300,000 IU / g. g Vitamin A palmitate crystalline, 1,700,000 IU / g 26.50 ethoxyquin 13.20 coffee powder 10.00 glycerin 14.80 gelatin (B type, 300 bloom) 40.00 distilled water 220.00

Example 19 Instead of the emulsion suspension of Example 16, an emulsion suspension having the following composition was prepared, and gelatin beads were obtained by the method of Example 16. The gelatin beads were heated in an electric oven at a set temperature of 150 ° C for 15 minutes. The gelatin beads thus obtained had a vitamin A activity of 490,000 IU / g. g Vitamin A acetate, crystalline, 2,800,000 IU / g 30.00 Ethoxyquin 15.00 Coffee powder 10.00 Glycerin 14.80 Gelatin (B type, 200 bloom) 50.00 Distilled water 230.00

Example 20 Instead of the emulsion suspension of Example 16, an emulsion suspension having the following composition was prepared, and gelatin beads were obtained by the method of Example 16. The gelatin beads were heated in an electric oven at a set temperature of 150 ° C for 15 minutes. The gelatin beads thus obtained had a vitamin A activity of 510,000 IU / g. g Vitamin A acetate, crystalline, 2,800,000 IU / g 30.00 Ethoxyquin 15.00 Coffee powder 15.00 Glycerin 14.80 Gelatin (Type B, 100 Bloom) 55.00 Distilled water 240.00

Example 21 Instead of the emulsion suspension of Example 16, an emulsion suspension having the following composition was prepared, and gelatin beads were obtained by the method of Example 16. The gelatin beads were heated in an electric oven at a set temperature of 150 ° C for 15 minutes. The gelatin beads thus obtained had 10% folic acid. g Folic acid 12.00 Coffee powder 5.00 Glycerin 10.00 Gelatin (type A, 300 bloom) 31.00 Distilled water 200.00

Example 22 Instead of the emulsion suspension of Example 16, an emulsion suspension having the following composition was prepared, and gelatin beads were obtained by the method of Example 16. The gelatin beads were heated in an electric oven at a set temperature of 150 ° C for 15 minutes. The gelatin beads thus obtained had 51.6% vitamin E. g dl-α-tocopherol 50.00 Coffee powder 5.00 Glycerin 10.00 Gelatin (B type, 300 bloom) 30.00 Distilled water 220.00

Comparative Example 7 An emulsified suspension in which coffee powder was omitted from the composition of Example 16 was prepared, and gelatin beads were obtained by the method of Example 16. The gelatin beads were heated in an electric oven at a set temperature of 150 ° C for 15 minutes. The gelatin beads thus obtained had a vitamin A activity of 530,000 IU / g.

Comparative Example 8 An emulsion suspension similar to that of Example 16 was prepared, and gelatin beads were obtained by the method of Example 16. The gelatin beads were heated in an electric oven at a set temperature of 100 ° C for 15 minutes.
The gelatin beads thus obtained have a vitamin A activity of 5
It had 20,000 IU / g.

Comparative Example 9 Vitamin A acetate crystallinity was previously melted at 65 ° C., and after melting, 26.5 parts by weight and 13.25 parts by weight of ethoxyquin were mixed. Further, to 220 parts by weight of distilled water heated in advance to 65 ° C., an emulsion suspension of 45.4 parts by weight of gum arabic, 14.8 parts by weight of glycerin and 8 parts by weight of lactose was adjusted to a sufficient concentration for spraying, The gum arabic beads obtained by the method of Example 7 were heated in an electric oven at a set temperature of 150 ° C for 15 minutes. The gum arabic beads thus obtained have a vitamin A activity of 480,000.
It had an IU / g. Table 5 shows the main compositions and heating temperatures of Examples 16 to 22 and Comparative Examples 7 to 9 described above.

[0052]

[Table 5]

Test Example 3 The fat-soluble vitamin-containing beads obtained in Examples 16 to 22 and Comparative Examples 7 to 9 were subjected to a storage test. The test method was as follows: Weigh about 50 g of fat-soluble vitamin-containing gelatin beads into a white bottle (PS-6K, manufactured by Daiichi Glass Co., Ltd.), open the lid, and
Put it in a desiccator under the condition of 0 ℃ and RH53% to block the light, and
The residual rate after storage for 6 months was measured. The results are shown in Table 6.

[0054]

[Table 6]

[0055]

INDUSTRIAL APPLICABILITY The powdery and granular composition of the present invention has a sufficiently stabilized activity of vitamins, especially fat-soluble vitamins, and can be used in a wide variety of fields.

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁶ Identification number Reference number within the agency FI Technical display area A61K 47/42 A61K 47/42 J 47/46 J 47/46 9/14 R

Claims (6)

[Claims] 1. A powdery or granular composition comprising at least one of gallic acid, whey or coffee, vitamins and gelatin. 2. A composition according to claim 1 which is a stabilized powdery composition. 3. The composition according to claim 1, wherein the vitamins are fat-soluble vitamins. 4. The composition according to claim 3, wherein the fat-soluble vitamins are vitamin A. 5. A method for producing a powdery or granular composition, which comprises subjecting gelatin beads comprising at least one of gallic acid, whey or coffee, vitamins, gelatin and water to heat treatment. 6. The method according to claim 5, wherein the heating temperature is about 130 to 180 ° C.