JPH0731187B2 - Test tool - Google Patents
Test toolInfo
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- JPH0731187B2 JPH0731187B2 JP63294674A JP29467488A JPH0731187B2 JP H0731187 B2 JPH0731187 B2 JP H0731187B2 JP 63294674 A JP63294674 A JP 63294674A JP 29467488 A JP29467488 A JP 29467488A JP H0731187 B2 JPH0731187 B2 JP H0731187B2
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- sample
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- blood
- amount
- test device
- Prior art date
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- Investigating Or Analysing Biological Materials (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Description
【発明の詳細な説明】 ［産業上の利用分野］ 本発明は、生体成分を検出するための試験具に関する。
特に、体液成分の分析のために、過剰供給の体液でも適
宜に分析できる試験具に関する。TECHNICAL FIELD The present invention relates to a test device for detecting a biological component.
In particular, the present invention relates to a test device that can appropriately analyze even an excessively supplied body fluid for the analysis of body fluid components.
［従来の技術及び発明が解決しようとする問題点］ 臨床検査分野において、尿や血液等の体液中の特定成分
を検出或いは定量する手段として、必要とする一定量の
試薬を含ませたドライタイプの試験片が、普及してい
る。即ち、液体検体中の特定成分を乾式で迅速、簡便に
定量する多層分析片（多層分析素子又は多層分析要素と
も称される）は、既に公知である。例えば、特開昭49−
53888号（米国特許第3992158号に対応）、特開昭50−13
7192号、特開昭51−40191号、特開昭52−3488号、特開
昭52−131786号、特開昭53−131089号、特開昭54−2970
0号、特開昭54−34298号、特公昭61−61347号、米国第4
110079号、米国第4132528号などの各明細書及び［Clini
cal Chemistry］誌第24巻第1335〜1350頁（1978年）な
どに詳細に記述されている。[Problems to be Solved by Conventional Techniques and Inventions] In the field of clinical examination, as a means for detecting or quantifying a specific component in a body fluid such as urine or blood, a dry type containing a certain amount of a necessary reagent The test piece is widely used. That is, a multilayer analytical piece (also referred to as a multilayer analytical element or a multilayer analytical element) for quantifying a specific component in a liquid sample by a dry method quickly and simply is already known. For example, JP-A-49-
No. 53888 (corresponding to US Pat. No. 3,992,158), JP-A-50-13
7192, JP 51-40191, JP 52-3488, JP 52-131786, JP 53-131089, JP 54-2970.
No. 0, JP-A-54-34298, JP-B-61-61347, US No. 4
110079, US 4132528 and other specifications and [Clini
cal Chemistry] Vol. 24, pp. 1335-1350 (1978).
これらの多くは、尿や血液等の検体を試験具上に所定手
段で供給するだけで、検体中の特定成分と反応し、その
結果生じる化学的変化や物性変化を検出するものであ
る。また、これらは、厳密な検体秤取を必要としないと
しているが、検体中の特定成分の含有量に応じた化学的
変化や物性変化を生じさせるためには、試験具に供給す
る検体の量を所定範囲に一定に保持する必要があった。
その手段としては、従来は、微小量の検体を正確に採取
できる採取器具を用いて検体を試験具に供給する方法
や、任意量の検体を試験具に供給した後、一定時間後に
過剰な検体を水洗や吸い取り紙等で除去するといった方
法が用いられていた。Most of these are for detecting a chemical change or physical property change that is caused by reacting with a specific component in the sample by simply supplying a sample such as urine or blood onto the test device by a predetermined means. In addition, although these do not require strict sample weighing, in order to cause chemical changes and physical property changes depending on the content of specific components in the sample, the amount of sample supplied to the test device Had to be kept constant within a predetermined range.
Conventionally, a method of supplying a specimen to a test device by using a sampling device capable of accurately collecting a minute amount of sample or an excessive amount of sample after a predetermined time after supplying an arbitrary amount of sample to the test device Methods such as washing with water or removing with absorbent paper were used.
然し乍ら、これらは、専用の採取具を用いる方法にあっ
ては、高度な専門的技術が要求され、専門家が、多量の
検体について行なうに適した方法である。また、後者の
方法では、検体を供給した後、過剰な検体を除去するま
での時間を厳密に定める必要があり、またその操作が繁
雑なため測定誤差を生じる原因ともなる。However, these methods require a high degree of specialized skill in the method of using a dedicated sampling tool, and are methods suitable for a specialist to perform on a large amount of specimens. Further, in the latter method, it is necessary to strictly determine the time from the supply of the sample to the removal of the excess sample, and the operation is complicated, which causes a measurement error.
本発明は、このような従来技術の問題点を省みて成され
たものであり、任意量の検体を供給し、その後の過剰量
の検体の除去を必要としない、試験具を提供することを
目的とする。また、本発明は、専門家でなくても、ま
た、患者自身でも、体液の特定成分を検出或いは定量す
ることができるように、検体量に厳密さを要求されない
で、分析試験ができる試験具を提供することを目的とす
る。The present invention has been made in view of the above-mentioned problems of the prior art, and provides a test device which supplies an arbitrary amount of sample and does not require subsequent removal of an excessive amount of sample. To aim. In addition, the present invention is a test device that can perform an analytical test without requiring strictness in the amount of a sample so that a specific component of body fluid can be detected or quantified even by an expert or a patient himself / herself. The purpose is to provide.
［問題点を解決するための手段］ 本発明の要旨とするものは、液体成分を分析するための
試験具において、担体層と、検知体層と、展開材層と、
液体を該展開材層に点着せしめるための貫通孔を有する
吸収体層とを備え、各層がこの順に互いに実質的に間隙
を有しないように積層するよう、枠で取り囲み挟んだこ
とを特徴とする前記試験具である。[Means for Solving Problems] A gist of the present invention is to provide a carrier for a liquid component, a carrier layer, a detector layer, a developing material layer,
An absorber layer having a through hole for spotting a liquid on the spreading material layer, and the layers are surrounded by a frame so that the layers are stacked in this order so that there is substantially no gap between them. The above-mentioned test tool.
本発明による液体検体（血液など）中の特定成分を分析
するための試験具では、担体と、その上に、検体（体
液、例えば血液）中の特性成分と反応し、その化学的変
化を検出するための反応検知体（層）と、その反応検知
体に液体検体を供給し、或いは展開する検体供給体
（層）即ち、展開体（層）を有する構造で、その検体供
給体の前段として、適当量の検体を供給できるように、
以下説明する性能を有する過剰検体吸収体（層）を設け
たものである。即ち、過剰な体液検体を吸収してしまう
液体吸収能のある吸収体層を、検体供給又は展開の前段
として、設けたものである。The test device for analyzing a specific component in a liquid sample (such as blood) according to the present invention detects a chemical change by reacting with a carrier and a characteristic component in a sample (body fluid such as blood). A structure having a reaction detector (layer) and a sample supplier (layer) for supplying or developing a liquid sample to the reaction detector, that is, a developer (layer), as a pre-stage of the sample supplier. , So that an appropriate amount of sample can be supplied,
An excess analyte absorber (layer) having the performance described below is provided. That is, an absorber layer having a liquid-absorbing ability to absorb an excess body fluid sample is provided as a pre-stage of sample supply or development.
そして、その過剰量の検体を吸収する吸収体としては、
織布、編物、不織布、ロ紙や非繊維性多孔質等の適度の
吸収性を有する素材が、使用できるが、特に、織布或い
は編物が、好適である。And, as an absorber that absorbs the excess amount of the sample,
A material having an appropriate absorbability such as woven cloth, knitted cloth, non-woven cloth, paper or non-fibrous porous material can be used, but woven cloth or knitted cloth is particularly preferable.
また、これらの素材は、吸収速度を向上させるために、
界面活性剤を含浸させるという化学的手段や、プラズマ
処理、コロナ放電処理、紫外線処理等の物理的手段によ
って、親水化されていることが、望ましい。In addition, these materials, in order to improve the absorption rate,
It is desirable that the surface is hydrophilized by a chemical means such as impregnation with a surfactant or a physical means such as plasma treatment, corona discharge treatment, and ultraviolet treatment.
［作用］ 試験具上に血液検体を滴下して測定を行なう場合を例に
して、本発明の作用を説明する。[Operation] The operation of the present invention will be described by taking as an example the case where a blood sample is dropped on a test tool for measurement.
試験具には、担体の上に設けられた、検体（血液）中の
特性成分と反応し、その化学的変化を検出するための反
応検知体として、（１）ロ紙や布等の高吸収性担体に反
応試薬溶液を含浸乾燥させて、作製された高吸収性反応
性担体や、（２）反応試薬を含むポリマー溶液をプラス
チック担体上に塗布して作製された反応検知体がある。
後者（２）については、更に、試験具上に検体を広範囲
に供給するための検体展開材が設置される。従って、従
来の試験具においては、所定量の血液が、試験具に供給
されると、第３図Ｃに示すように、血液は、矢印で示す
ように、血液は、試験具の高吸収性反応性担体或いは検
体展開材層３′の中を横方向に沿って展開するととも
に、試験具の高吸収性反応性担体或いは検体展開材層
３′の中を縦方向にも、浸透し、試験具の反応性担体層
２′或いは反応性検知体層に含有された試薬との反応が
開始される。この際に、供給された血液９は、図示のよ
うに、層３′の上で球状になり、層３′の中への拡散
は、急速には行かない。また、拡散が開始されても、横
方向への展開に多くの時間を要し、検体量が滴下された
部位の単位面積当りの検体量が、一定となるまでに反応
が進行してしまい、測定誤差を生じる。The test tool is a reaction detector that is provided on the carrier and that reacts with the characteristic components in the sample (blood) and detects its chemical changes. (1) High absorption of paper or cloth There are a superabsorbent reactive carrier prepared by impregnating and drying a reactive reagent solution in a reactive carrier, and a reaction detector prepared by (2) coating a polymer solution containing a reactive reagent on a plastic carrier.
Regarding the latter (2), a sample developing material for supplying a sample over a wide range is further installed on the test tool. Therefore, in the conventional test device, when a predetermined amount of blood is supplied to the test device, as shown in FIG. 3C, the blood has the high absorbency of the test device, as shown by the arrow. The test is carried out along the horizontal direction in the reactive carrier or the sample developing material layer 3 ', and also penetrates in the vertical direction through the highly absorbent reactive carrier or the sample developing material layer 3'of the test tool to test. The reaction with the reagent contained in the reactive carrier layer 2'or the reactive detector layer of the ingredient is started. At this time, the supplied blood 9 becomes spherical on the layer 3 ', as shown in the figure, and diffusion into the layer 3'does not occur rapidly. Further, even if the diffusion is started, it takes a lot of time to develop in the lateral direction, and the amount of the sample per unit area of the site where the sample amount is dropped, the reaction proceeds until it becomes constant, It causes measurement error.
これに対して、本発明では、第３図Ａに示すように、５
に滴下された血液は、過剰量が、周囲にある吸収体４に
吸収される。即ち、少なくとも、血液を滴下する部位５
を除く周囲に過剰な血液を吸収する吸収体層４を設ける
ことにより、血液が滴下された部位５の単位面積当りの
血液量を極く短時間で一定化させ、展開材層３中を一定
濃度で拡散され、検知体層２に供給される量は、ほぼ一
定にされ、即ち、検知体２中での反応に寄与する血液の
量を規定できる。従って、検体（血液）中の特性成分の
量に応じた化学変化が迅速に検知されることを可能にで
きる。On the other hand, in the present invention, as shown in FIG.
An excessive amount of the blood that has been dripped onto is absorbed by the surrounding absorber 4. That is, at least the part 5 where the blood is dropped
By providing an absorber layer 4 that absorbs excess blood in the surroundings except for the above, the amount of blood per unit area of the site 5 onto which the blood is dropped can be made constant in a very short time, and the expansion material layer 3 can be made constant. The amount diffused at a concentration and supplied to the sensing body layer 2 is made substantially constant, that is, the amount of blood contributing to the reaction in the sensing body 2 can be defined. Therefore, it is possible to promptly detect a chemical change according to the amount of the characteristic component in the sample (blood).
本発明の試験体に利用する液体吸収体の材料は、例え
ば、綿、化学繊維等の素材を用いた液体吸収能を有する
構造としたものである。具体的には、ナイロン／ポリエ
ステル編物を用いることができる。その液体吸収能は、
血液などの体液をある程度吸収することのできるもので
ある。The material of the liquid absorber used in the test body of the present invention is, for example, a material having a liquid absorbing ability made of a material such as cotton or chemical fiber. Specifically, a nylon / polyester knitted fabric can be used. Its liquid absorption capacity is
It is capable of absorbing body fluids such as blood to some extent.
本発明に用いる液体吸収体の構造は、下記に説明するよ
うに、貫通孔を有するものが好適である。例えば、第３
図Ｂに示すように、検体を滴下すべき個所即ち、貫通孔
５の位置が、指のみの感触で感知でき、それにより、容
易に、検体点着ができる。また、貫通孔は、試験に適用
する体液検体の物性に依存するものである。即ち、検体
が滴下された部位の単位面積当りの検体量を極く短時間
で一定化させ、反応検知体中での反応に寄与する検体の
量を規定通りに一定にすることのできる構造のものであ
る。また、この貫通孔の大きさを、調整することによ
り、液体検体が、反応検知体に供給される速度を調節す
ることができる。The structure of the liquid absorber used in the present invention preferably has a through hole, as described below. For example, the third
As shown in FIG. B, the position where the sample should be dropped, that is, the position of the through hole 5 can be sensed by the feel of only the finger, and thus the sample can be easily spotted. The through hole depends on the physical properties of the body fluid sample applied to the test. That is, the amount of the sample per unit area of the portion where the sample is dropped can be made constant in a very short time, and the amount of the sample contributing to the reaction in the reaction detector can be made constant as specified. It is a thing. Also, by adjusting the size of the through hole, the speed at which the liquid sample is supplied to the reaction detector can be adjusted.
従って、反応検知体の能力に合わせて、試験具の構造を
決めることができる。Therefore, the structure of the test tool can be determined according to the ability of the reaction detector.
次に本発明による試験具を、第１図Ａに示し、従来の試
験具による構造を第１図Ｂに示し、比較する。Next, the test device according to the present invention is shown in FIG. 1A, and the structure of the conventional test device is shown in FIG. 1B for comparison.
従来技術による試験具（第１図Ｂ）の構造では、例え
ば、ゼラチン溶液を、ポリエチレンテレフタレート製透
明フィルム（透明担体）１上に塗布乾燥することによ
り、反応検知層（血球ロ過・反応フィルム）２を形成す
る。そして、その上に、検体を均一に展開させるための
展開部材（血液展開ニット）３として、編物を積層させ
たものである。In the structure of the test device (FIG. 1B) according to the prior art, for example, a gelatin solution is applied onto a transparent film (transparent carrier) 1 made of polyethylene terephthalate and dried to give a reaction detection layer (blood cell filtration / reaction film). Form 2. Then, a knitted fabric is laminated thereon as a spreading member (blood spreading knit) 3 for uniformly spreading the sample.
これに対して、本発明の試験具構造では、第１図Ａに示
すように、透明担体層１の上に、反応検知剤を含むゼラ
チン溶液を塗布乾燥した反応検知層（血球ロ過・反応フ
ィルム）２と、その上に、血液展開ニットによる展開部
材層３に積層し、その展開部材３の上に、検体滴下のた
めの貫通孔５を有する編物より成る過剰検体吸収材４
（吸血ニニット）を積層したものである。そして、全体
をプラスチック枠６で取り囲み、挾んだものである。検
知分析は、第１図Ａの上から、血液検体を凹部５に点着
する。すると、血液は、過剰量が吸収体層４に吸収され
るが、展開体層３は、一定供給量で供給され、検知層２
に迅速に所定量で、浸透し、そこで反応検知体と反応
し、呈色する。その呈色を、７で示す側から、所定波長
の光源で検知し、その呈色濃度を測定するものである。
このように本発明の試験具では、吸収体層４の中央に貫
通孔５があるために、供給された液体検体（血液等）
は、貫通孔５の周囲にある吸収体４に周りから均等に吸
収される。然し乍ら、例えば、第１図Ｂに示すような構
造では、試薬層或いは展開部材層（３）を経由して、吸
収されていたために、その層を通過する間に反応が進行
するなどの欠点があるものであった。On the other hand, in the test device structure of the present invention, as shown in FIG. 1A, a reaction detection layer (blood cell filtration / reaction) obtained by coating and drying a gelatin solution containing a reaction detection agent on the transparent carrier layer 1. Film) 2 and an excess sample absorbent material 4 composed of a knitted fabric having a through-hole 5 for laminating a film 2 thereon and a spreading member layer 3 made of a blood spreading unit and having a through hole 5 for dropping a sample.
(Blood sucking unit) is laminated. Then, the whole is surrounded by a plastic frame 6 and sandwiched. In the detection analysis, a blood sample is spotted on the recess 5 from the top of FIG. 1A. Then, an excessive amount of blood is absorbed by the absorber layer 4, but the spreader layer 3 is supplied at a constant supply amount and the detection layer 2 is supplied.
Rapidly permeates a predetermined amount, reacts with the reaction detector there, and is colored. The color development is detected from the side indicated by 7 with a light source of a predetermined wavelength, and the color density is measured.
As described above, in the test device of the present invention, since the through-hole 5 is provided at the center of the absorber layer 4, the supplied liquid sample (blood, etc.)
Are uniformly absorbed by the absorber 4 around the through-hole 5 from the surroundings. However, for example, in the structure as shown in FIG. 1B, since it is absorbed via the reagent layer or the spreading member layer (3), there is a drawback that the reaction proceeds while passing through the layer. It was something.
次に、本発明による試験具での分析試験を、具体例によ
り説明するが、本発明は、次の説明に限定されるもので
はない。Next, the analytical test with the test device according to the present invention will be described with reference to specific examples, but the present invention is not limited to the following description.
［実施例］ 反応検知層２に、グルコースオキシダーゼ、ベルオキシ
ダーゼ、Ｌ−アミノアンチピリン、Ｎ−エチル−Ｎ−
（２−ヒドロキシ−３−スルホプロピル）−ｍ−トルイ
ジンを反応試薬として含有し、二酸化チタン粉末を分散
させたゼラチンよりなるものを使用して、第１図Ａの構
造で作製した試験具と、同じ試薬と構成で作製した反応
検知層を有する第１図Ｂに示す構造で作製した試験具と
について、次のような実験を行なった。[Example] Glucose oxidase, peroxidase, L-aminoantipyrine, N-ethyl-N- was added to the reaction detection layer 2.
A test device prepared by the structure shown in FIG. 1A using a gelatin containing (2-hydroxy-3-sulfopropyl) -m-toluidine as a reaction reagent and containing titanium dioxide powder dispersed therein, The following experiment was conducted on the test tool manufactured with the structure shown in FIG. 1B having the reaction detection layer manufactured with the same reagent and structure.
各々100mg/dl及び300mg/dlの濃度のブドウ糖を含む血液
を、本発明の試験具及び従来の試験具を用いて、検量し
た。この場合、反応検知体では、次の反応が生じるもの
である。Blood containing glucose at concentrations of 100 mg / dl and 300 mg / dl, respectively, was calibrated using the test device of the present invention and a conventional test device. In this case, the reaction detector produces the following reaction.
グルコース＋酸素→（グルコースオキシダーゼ）→グル
コン酸＋過酸化水素（H2O2） 過酸化水素＋色原体→（ペルチオキシダーゼ）→色素＋
水（H2O） この検量のための滴下量について、10〜40μｌの範囲に
変化させて、各々上記の構造の試験具に滴下し、滴下２
分後の呈色の強度を、波長565nmにおいて、呈色前に対
する反射光の相対強度として、測定した。測定値を、変
化させた滴下量に対してブロットしたグラフを第２図に
示した。Glucose + oxygen → (glucose oxidase) → gluconic acid + hydrogen peroxide (H 2 O 2 ) hydrogen peroxide + chromogen → (pertioxidase) → dye +
Water (H 2 O) The dropping amount for this calibration was changed to a range of 10 to 40 μl, and the dropping amount was dropped on the test device having the above structure.
The intensity of the coloration after the minute was measured at a wavelength of 565 nm as the relative intensity of the reflected light to that before the coloration. FIG. 2 shows a graph in which the measured values are blotted against the dropped amount.
第１図Ａに示す試験具で測定したものを、○と実線で示
し、第１図Ｂに示す試験具構造で測定した結果を●と点
線で示し、比較例とする。また、100mg/dlのブドウ糖濃
度血液の試験結果をＩで、300mg/dlのブドウ糖濃度血液
の試験結果をIIで示す。What is measured by the test tool shown in FIG. 1A is shown by a circle and a solid line, and the result measured by the test tool structure shown in FIG. 1B is shown by a black circle and it is set as a comparative example. In addition, the test result of glucose concentration blood of 100 mg / dl is shown by I, and the test result of glucose concentration blood of 300 mg / dl is shown by II.
第２図のグラフに示すように、本発明の試験具で測定し
たものは、実線で示すように、滴下量即ち、検体の量に
影響されずに、ほぼ一定の値で検知することが、明らか
にされた。As shown in the graph of FIG. 2, what is measured by the test device of the present invention can be detected at a substantially constant value without being affected by the dropping amount, that is, the amount of the sample, as shown by the solid line. Was revealed.
［発明の効果］ 本発明の試験具は、反応検知層に一定量の体液即ち、検
体を供給するように、過剰検体吸収体を設けたことによ
り、 第１に、従来の試験体と異なり、検体量が過剰でも正確
な検知ができる試験体を提供すること、 第２に、広い範囲で検体量の制約を受けずに、検体中の
成分濃度を精度よく検出できる試験具を提供したこと、 第３に、専門家でない者、例えば、患者でも、簡便で操
作容易に、自己の体液を分析検知できる試験具が提供さ
れたこと、 などの著しい技術的効果を奏するものである。EFFECTS OF THE INVENTION The test device of the present invention is provided with an excess sample absorber so as to supply a fixed amount of body fluid, that is, a sample to the reaction detection layer. To provide a test sample that can be accurately detected even if the amount of the sample is excessive. Secondly, to provide a test device that can accurately detect the concentration of components in the sample without being restricted by the amount of the sample in a wide range. Thirdly, it provides a remarkable technical effect such as the provision of a test tool that enables even non-specialists such as patients to analyze and detect their own body fluids easily and easily.
第１図Ａ、Ｂは、本発明の試験具を説明するため、従来
の試験具と比較して示した説明断面図である。 第２図は、本発明の試験具による測定値と従来の試験具
による測定値を比較したグラフである。 第３図Ａ、Ｂ、Ｃは、本発明の試験具を説明するための
説明図である。 ［主要部分の符号の説明］ １……透明担体 ２……反応検知体層 ３……検体展開層 ４……過剰検体吸収体 ５……貫通孔FIGS. 1A and 1B are explanatory sectional views showing a test tool of the present invention in comparison with a conventional test tool. FIG. 2 is a graph comparing the measured values of the test device of the present invention and the conventional test device. 3A, 3B and 3C are explanatory views for explaining the test device of the present invention. [Explanation of symbols of main parts] 1 ... Transparent carrier 2 ... Reaction detector layer 3 ... Sample spreading layer 4 ... Excess sample absorber 5 ... Through hole
フロントページの続き (72)発明者 鈴木 宏 東京都渋谷区幡ケ谷２丁目44番１号 テル モ株式会社内 (72)発明者 野村 武男 東京都渋谷区幡ケ谷２丁目44番１号 テル モ株式会社内 (56)参考文献 特開 昭57−182648（ＪＰ，Ａ)Front page continued (72) Inventor Hiroshi Suzuki 2-44-1, Hatagaya, Shibuya-ku, Tokyo Terumo Corporation (72) Inventor Takeo Nomura 2-44-1, Hatagaya, Shibuya-ku, Tokyo Terumo Corporation (56) References JP-A-57-182648 (JP, A)
Claims (2)
て、担体層と、検知体層と、展開材層と、液体を該展開
材層に点着せしめるための貫通孔を有する吸収体層とを
備え、各層はこの順に互いに実質的に間隙を有しないよ
うに積層するよう、枠で取り囲み挟んだことを特徴とす
る前記試験具。1. A test tool for analyzing a liquid component, comprising a carrier layer, a detector layer, a developing material layer, and an absorber layer having a through hole for spotting the liquid on the developing material layer. The test tool, wherein each layer is surrounded by a frame so as to be laminated in this order so as not to have a substantial gap therebetween.
物、編物、不織布、ロ紙又は非繊維製多孔質よりなるこ
とを特徴とする請求項１に記載の試験具。2. The test tool according to claim 1, wherein the absorbent layer is made of a hydrophilically treated woven fabric, knitted fabric, non-woven fabric, paper or non-fiber porous material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63294674A JPH0731187B2 (en) | 1988-11-24 | 1988-11-24 | Test tool |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63294674A JPH0731187B2 (en) | 1988-11-24 | 1988-11-24 | Test tool |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH02141664A JPH02141664A (en) | 1990-05-31 |
| JPH0731187B2 true JPH0731187B2 (en) | 1995-04-10 |
Family
ID=17810836
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP63294674A Expired - Lifetime JPH0731187B2 (en) | 1988-11-24 | 1988-11-24 | Test tool |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0731187B2 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2519157B2 (en) * | 1992-10-05 | 1996-07-31 | 敏夫 高岡 | AIDS check device |
| SE539853C2 (en) | 2016-02-03 | 2017-12-19 | Hemcheck Sweden Ab | An arrangement for collection and separation of a body fluidfor purposes of analysis and a method relating thereto |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4323536A (en) * | 1980-02-06 | 1982-04-06 | Eastman Kodak Company | Multi-analyte test device |
| JPS57182648A (en) * | 1981-05-06 | 1982-11-10 | Fuji Photo Film Co Ltd | Analysis sheet of multilayer liquid |
| DE3530993A1 (en) * | 1985-08-30 | 1987-03-05 | Miles Lab | TEST STRIP WITH DETERMINABLE SAMPLE CAPACITY |
-
1988
- 1988-11-24 JP JP63294674A patent/JPH0731187B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPH02141664A (en) | 1990-05-31 |
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