JPH07275284A - Cancer therapeutic method and device therefor - Google Patents

Abstract

PURPOSE:To provide a cancer therapeutic method and a device therefor for effacing a center effectively by radiating weak ultrasonic wave toward a cancer lesion part. CONSTITUTION:The vibrating face of an ultrasonic vibrator 1 is brought into contact with a body external part close to a lesion part directly or through a sound wave conductor 6 and fixed by an adhesive tape 2 or a gel like adhesive body, and an oscillating circuit and a power supply are connected to the ultrasonic vibrator 1 through a lead wire 3. Ultrasonic wave of 0.3mW to 0.5W in sound pressure for 1cm<2> and 20kHz to 100MHz in frequency is radiated toward the lesion. In this cancer therapeutic method and a device of such constitution, the cancer cells of the lesion part are positively effaced by radiating weak ultrasonic wave to the lesion part of the body from the ultrasonic vibrator 1 for many hours.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a cancer treatment method and apparatus for effectively eliminating cancer in an affected area by radiating weak ultrasonic waves toward the affected area.

[0002]

2. Description of the Related Art Conventionally, as a cancer treatment method using ultrasonic waves,
A paper has been published that suppresses the growth of cancer cells by irradiating ultrasonic waves of 2 W or more per square centimeter for 30 minutes at a temperature of 37 to 43 degrees Celsius (see Nature Vol. 267 12 May 1977). .

By the way, since it is generally known that cancer cells are weak against heat, such a cancer treatment method suppresses the growth of cancer by assisting the heating of the affected area with ultrasonic waves. .

[0004]

However, in such a cancer treatment method, it is necessary to constantly heat the affected area or the entire body, and therefore the apparatus becomes complicated and
There is a problem that the cost becomes high, and there is a possibility that a long-term irradiation may have a harmful effect on normal cells.

[0005]

According to the present invention, the sound pressure is 0.5 mW to 0.5 W per square centimeter from outside or inside the body toward the affected area, and the frequency is from 20 kHz to 1.
This is a method for treating cancer, in which ultrasonic waves of 00 MHz are applied, and the vibrating surface of the ultrasonic transducer is brought into direct contact with the outside of the body in the vicinity of the affected area, or is contacted through a good conductor of acoustic waves, An oscillator circuit and a power source are connected to the child through a lead wire, and a sound pressure is 0.5 mW to 0.5 per square centimeter from the vibration surface of the ultrasonic transducer.
It is a cancer treatment method in which an ultrasonic wave having a frequency of 20 kHz to 100 MHz at W is radiated toward the affected area.

[0006]

In the present invention, the sound pressure is 0.5 m per square centimeter from the ultrasonic transducer provided outside or inside the body.
From W to 0.5W, frequency is from 20kHz to 100MH
When ultrasonic waves of z are generated and the ultrasonic waves are applied to the cancer cells for a relatively long time, the cancer cells are suppressed from growing due to weak ultrasonic vibration, and normal cells around the cancer cells are activated.

Therefore, in the affected area irradiated with ultrasonic waves, the cancer cells gradually decrease and the surrounding normal cells increase.

[0008]

[Examples] The present inventors divided human eye pigment epithelial cells artificially transformed into cancer by the SV40 virus gene into two and proliferate them under the same conditions. When a continuous wave of sound waves was continuously irradiated and the other cancerous cells were allowed to proliferate without being irradiated with ultrasonic waves, the number of proliferation of cancerous cells not irradiated with ultrasonic waves is shown by the dotted line A in FIG. 1, the number of cancerous cells irradiated with ultrasonic waves was 1 on the second day as shown by the solid line B in FIG.
5% growth was suppressed, 18% on the 4th day, 31% on the 8th day
Also the proliferation of cancer cells was reduced.

Furthermore, it was discovered that normal cells of the pigment epithelial cells of the eyes of chicken embryos used in the comparative experiment were activated by ultrasonic waves and increased.

[0010] This is because the proliferation of cancer cells can be suppressed by irradiating the cancerous cells with weak ultrasonic waves.
Normal cells are considered to be activated themselves.

Therefore, in order to obtain an effective ultrasonic wave condition for cancer cells, when the cancer cells are irradiated with ultrasonic waves having different frequencies and sound pressures, the sound pressure is 0.5 mW / sq. 5W, frequency from 20kHz to 1
It has been found that ultrasonic waves of 00 MHz act on cancer cells very effectively and that normal cells are significantly activated.

FIG. 2 is a block diagram of a cancer treatment apparatus for carrying out the cancer treatment method of the present invention. In order to irradiate the cancer cells with weak ultrasonic waves for a long time, the ultrasonic transducer 1 is an adhesive tape 2 for the affected area. It is configured so that it can be bonded to.

A lead wire 3 is connected to the ultrasonic vibrator 1, an oscillation circuit 4 is connected to the lead wire 3, and a power source 5 such as a battery is attached to the oscillation circuit 4.

Then, the ultrasonic vibrator 1 is fixed near the affected area with an adhesive tape 2, and the oscillation circuit 4 is adjusted so that the sound pressure from the ultrasonic vibrator 1 is 0.5 mW to 0.5 W per square centimeter. A weak ultrasonic wave with a frequency of 20 kHz to 100 MHz is generated.

With this configuration, the patient fixes only the small ultrasonic transducer 1 to the affected area on the skin surface with the adhesive tape 2, and the oscillation circuit 4 and the power source 5 are connected via the lead wire 3. Therefore, the oscillator circuit 4 and the power source 5 can be placed close to each other while sleeping, and the oscillator circuit 4 and the power source 5 can be inserted into a pocket or the like when the person is awake to live a daily life. The affected area can be irradiated with ultrasonic waves for a long time without any trouble.

FIG. 3 is a block diagram of a cancer treatment apparatus according to another embodiment of the present invention, in which 1 is an ultrasonic transducer, 2 is an adhesive tape, 3 is a lead wire, and these constitutions are the same as those in the above embodiment. Although the description is omitted because it is the same, in the present embodiment, the acoustic lens 6 is bonded to the ultrasonic wave emitting surface of the ultrasonic transducer 1, and
Although not shown, the oscillation circuit 4 and the power source 5 are connected to the lead wire 3.

In this embodiment, the acoustic lens 6 is provided on the outer surface of the body.
When the surfaces are contacted and fixed with the adhesive tape 2, the ultrasonic waves can be focused by the acoustic lens 6, so that the ultrasonic waves can be efficiently irradiated from the body surface to the affected part in the body.

When the acoustic lens 6 is used, ultrasonic waves can be radiated to the affected area without waste by arbitrarily selecting the focal length of the acoustic lens 6 according to the depth of the affected area.

FIG. 4 is a block diagram of a cancer treatment apparatus according to still another embodiment of the present invention, in which 2 is an adhesive tape and 3 is a lead wire, and these configurations are the same as those in the above-mentioned embodiment, and therefore description Although omitted, in the present embodiment, the emission surface of the ultrasonic transducer 1 is formed into a concave surface so that the ultrasonic waves emitted from the ultrasonic transducer 1 can be focused.

In this embodiment, the focal length of the ultrasonic transducer 1 is arbitrarily selected according to the depth of the affected area, so that ultrasonic waves can be radiated to the affected area without waste.

FIG. 5 is a block diagram of a cancer treatment apparatus according to still another embodiment of the present invention, in which a lead wire 3 is connected to the ultrasonic vibrator 1 and a cover 7 is provided on the ultrasonic vibrator 1. Further, a gel adhesive 8 which is a good conductor of sound waves is fixed to the ultrasonic wave emitting surface of the ultrasonic vibrator 1.

In this cancer treatment device, the gel adhesive 8 can be firmly fixed directly to the outer surface of the body, and the ultrasonic radiation surface of the ultrasonic transducer 1 is flat, so that a wide range of affected parts can be obtained. It is possible to effectively irradiate ultrasonic waves.

Although the ultrasonic vibrator 1 is fixed to the body with the adhesive tape 2 in the above embodiment, the ultrasonic vibrator 1 can be fixed to the body with a bandage or band.

FIG. 6 is a block diagram of a cancer treatment apparatus according to another embodiment of the present invention, in which a battery 9 provided as a power source is provided with an oscillating circuit 1.
0 is connected, and the battery 9 and the oscillation circuit 10 have an ultrasonic transducer 11 forming a flat capsule-shaped half and a synthetic resin capsule 12 forming the other half of the flat capsule at the joint portion. And is attached to the inside of the capsule 13, and the surface of the capsule 13 is coated with a material having good compatibility with the living body, if necessary.

In the capsule-type cancer treatment device of this embodiment having the above-mentioned structure, when the oscillator 10 is operated and the capsule 13 is embedded in the patient so that the ultrasonic oscillator 11 faces the affected area, the ultrasonic oscillator 11 The affected area is further irradiated with ultrasonic waves, the growth of cancer cells in the affected area can be suppressed, and the capsule can be made ultra-small, so just by performing a perforation operation on the skin surface,
It can be easily implanted in the body and is easy to operate and does not burden the patient.

In the embodiment shown in FIG. 6, half of the capsules 12 are made of synthetic resin, but the capsules 12 may be made of ultrasonic transducers.

FIG. 7 is a block diagram of a cancer treatment apparatus according to another embodiment of the present invention, in which ultrasonic transducers 15 and 1 are provided on the inner surface of the case 14.
6 is fixed at a position facing each other, a power supply 17 and an oscillation circuit 18 are mounted in the case 14, and the output of the oscillation circuit 18 is connected to the ultrasonic transducers 15 and 16.

This embodiment having the above-mentioned structure also has the same effect as that of the embodiment shown in FIG. 6, and in the embodiment shown in FIG. 7, two ultrasonic transducers are provided so as to face each other. Two or more ultrasonic transducers may be provided so that ultrasonic waves are generated from other portions.

FIG. 8 is a block diagram of a cancer treatment apparatus according to another embodiment of the present invention, in which a patient 19 enters a bath 21 filled with hot water 20 of a certain high temperature so that the patient 19 does not get cold, a power source and When the output of the transmitting device 22 equipped with the transmitter is input to the parabolic ultrasonic transducer 23, the ultrasonic waves described above are irradiated to the affected area 19a of the patient 19 to suppress the growth of cancer cells in the affected area 19a. To be

[0030]

INDUSTRIAL APPLICABILITY As described above, according to the present invention, by irradiating a patient's cancer cells with weak ultrasonic waves for a long period of time, the growth of cancer cell cancer is reliably suppressed, and normal cancer near the affected area is suppressed. It has the advantage that the cells are activated.

[Brief description of drawings]

FIG. 1 is a diagram comparing proliferation of cancer cells irradiated with ultrasonic waves and cancer cells not irradiated with ultrasonic waves for explaining the method of the present invention.

FIG. 2 is a configuration diagram of a cancer treatment apparatus according to an embodiment of the present invention.

FIG. 3 is a configuration diagram of a cancer treatment apparatus according to another embodiment of the present invention.

FIG. 4 is a configuration diagram of a cancer treatment apparatus according to still another embodiment of the present invention.

FIG. 5 is a configuration diagram of a cancer treatment apparatus according to still another embodiment of the present invention.

FIG. 6 is a configuration diagram of a cancer treatment apparatus according to still another embodiment of the present invention.

FIG. 7 is a configuration diagram of a cancer treatment apparatus according to still another embodiment of the present invention.

FIG. 8 is a configuration diagram of a cancer treatment apparatus according to still another embodiment of the present invention.

[Explanation of symbols]

 1 Ultrasonic Transducer 2 Adhesive Tape 3 Lead Wire 4 Oscillation Circuit 5 Power Supply 6 Acoustic Lens 7 Cover 8 Gel Adhesive 9 Battery 10 Oscillator 11 Capsule-Shaped Ultrasonic Transducer 12 Synthetic Resin Capsule 13 Capsule 14 Case 15, 16 Ultrasonic Transducer 17 Power Supply 18 Oscillation Circuit 19 Patient 19a Affected Area 20 Hot Water 21 Tank 22 Transmitter 23 Parabolic Ultrasonic Transducer

Claims (10)

[Claims] 1. The sound pressure is 1 from outside or inside the body toward the affected area.
A method for treating cancer, wherein ultrasonic waves having a frequency of 20 kHz to 100 MHz and having a frequency of 0.5 mW to 0.5 W per square centimeter are irradiated. 2. The vibrating surface of the ultrasonic transducer is brought into direct contact with the outside of the body in the vicinity of the affected area, or is contacted via a good acoustic conductor, and the ultrasonic transducer is connected to an oscillation circuit and a power source via lead wires. In addition, the sound pressure from the vibrating surface of the ultrasonic vibrator is 0.5 mW to 0.
A cancer treatment device, wherein ultrasonic waves having a frequency of 5 kHz and a frequency of 20 kHz to 100 MHz are radiated toward the affected area. 3. The cancer treatment device according to claim 2, wherein the fixture is an adhesive tape. 4. The cancer treatment device according to claim 2, wherein the fixing tool is a fixing band. 5. The cancer treatment device according to claim 2, wherein the fixture is a gel-like adhesive body. 6. The cancer treatment apparatus according to claim 2, wherein the good sonic conductor comprises an acoustic lens that focuses a sound wave. 7. The cancer treatment apparatus according to claim 2, wherein the ultrasonic transducer is formed so as to focus a sound wave. 8. An oscillating circuit and a power supply are built in a capsule-shaped ultrasonic vibrator, and an output terminal of the oscillating circuit is connected to the capsule-shaped ultrasonic vibrator to obtain the capsule-shaped ultrasonic vibrator. Embedded in the body, a cancer treatment in which ultrasonic waves having a sound pressure of 0.5 mW to 0.5 W per square centimeter and a frequency of 20 kHz to 100 MHz are irradiated toward the affected area from the vibration surface of the ultrasonic transducer apparatus. 9. An oscillating circuit, a power source, and an ultrasonic transducer are built in a capsule, and the output terminal of the oscillating circuit is connected to the ultrasonic transducer in the capsule to implant the capsule in the body. A cancer treatment device, wherein ultrasonic waves having a sound pressure of 0.5 mW to 0.5 W per square centimeter and a frequency of 20 kHz to 100 MHz are irradiated toward the affected area from the vibrating surface of the sound wave oscillator. 10. A parabolic ultrasonic transducer is mounted in a bath filled with hot water of an appropriate temperature, and the parabolic ultrasonic transducer is connected to an output terminal of an oscillator having a power supply and an oscillation circuit, Ultrasonic waves having a sound pressure of 0.5 mW to 0.5 W per square centimeter and a frequency of 20 kHz to 100 MHz are emitted from the vibrating surface of the ultrasonic transducer toward the affected area of the patient in the tank. Cancer treatment device.