JPH07255867A - Three-dimensional corpuscular radiation device - Google Patents
Three-dimensional corpuscular radiation deviceInfo
- Publication number
- JPH07255867A JPH07255867A JP4819894A JP4819894A JPH07255867A JP H07255867 A JPH07255867 A JP H07255867A JP 4819894 A JP4819894 A JP 4819894A JP 4819894 A JP4819894 A JP 4819894A JP H07255867 A JPH07255867 A JP H07255867A
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- Prior art keywords
- particle beam
- dimensional
- irradiation
- cyclotron
- neutron
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Abstract
Description
【０００１】[0001]
【産業上の利用分野】本発明は，中性子線又は陽子線等
の粒子線を照射対象物に照射する装置に関し，詳しく
は，癌治療等に用いられる医用３次元中性子照射装置に
関する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an apparatus for irradiating an irradiation object with a particle beam such as a neutron beam or a proton beam, and more particularly to a medical three-dimensional neutron irradiation apparatus used for cancer treatment or the like.
【０００２】[0002]
【従来の技術】現在，放射線による癌の治療に使用され
ているのは，主にＸ線電子線及び中性子線である。2. Description of the Related Art Currently, X-ray electron beams and neutron rays are mainly used for treating cancer by radiation.
【０００３】この種の放射線治療用装置として，特公昭
５１−１５３５７号公報，特開昭５３−１４２９７号公
報，特開昭５３−７２３９２号公報，（以下，夫々従来
技術１，２及び３と呼ぶ）に開示されたものがある。Japanese Patent Publication No. 51-15357, Japanese Patent Laid-Open No. 53-14297, Japanese Patent Laid-Open No. 53-72392, (hereinafter referred to as prior arts 1, 2 and 3 respectively) Called) has been disclosed.
【０００４】従来技術１には，中性子発生源は動かさず
に，治療台を水平姿勢を保ったまま動かすことと，コリ
メーターを側部に動かすように構成した照射装置が開示
されている。[0004] Prior art 1 discloses an irradiation device configured to move a treatment table while keeping a horizontal posture without moving a neutron source and to move a collimator to a side part.
【０００５】従来技術２には，サイクロトロンを用いた
中性子治療設備が開示されている。これらの中性子治療
設備の幾例かを，図５乃至図８に示す。Prior art 2 discloses a neutron treatment facility using a cyclotron. Some examples of these neutron treatment facilities are shown in FIGS.
【０００６】図５の例では，コンクリート壁１３２の対
向面間に渡って設けられ，枢軸１２８とこの枢軸にサイ
クロトロン１３０を回転可能に設けるとともに，プラッ
トホーム上に台座１４０を設け，この台座１４０を患者
を横および垂直方向に移動可能としたもので，中心軸に
交差する面内での患者の中心軸に平行な患部を通る軸回
りに照射角度を変える２次元照射装置を示している（詳
しくは，従来技術２の第７図と，その説明を参照）。In the example shown in FIG. 5, a pivot shaft 128 and a cyclotron 130 are rotatably provided on opposing faces of the concrete wall 132, and a pedestal 140 is provided on the platform. FIG. 2 shows a two-dimensional irradiation device in which the irradiation angle is changed around the axis passing through a diseased part parallel to the central axis of the patient in a plane intersecting with the central axis, which is movable in the horizontal and vertical directions. , FIG. 7 of Prior Art 2 and its description).
【０００７】また，図６の例では，サイクロトロン１０
０を対象軸１０１の回りに自転させ，それとともに治療
台（図示せず）を垂直に移動させるように構成してお
り，図５と同様に２次元照射装置を示している（詳しく
は，従来技術２の第８図と，その説明を参照）。In the example of FIG. 6, the cyclotron 10
0 is rotated around the target axis 101, and a treatment table (not shown) is moved vertically with it, showing a two-dimensional irradiation device as in FIG. (See Fig. 8 of Technology 2 and its explanation).
【０００８】また，図７の例では，患者治療台の周り
に，中空軸１０７を中心として回転するＵ型フレーム１
０５を回転させ，このＵ型フレーム１０５に保持された
サイクロトロン１００を軸１１１の周りに回転させるも
ので，壁部１０６に支持された中空軸１０７と同心的に
設けられた歯車に噛み合う歯車１０８によって駆動され
る軸１０９及びＵ型フレーム１０５の一端の軸１１０に
より，サイクロトロンへ回転力を伝達するように構成し
ている２次元照射装置が示されている（詳しくは，従来
技術２の第９図と，その説明を参照）。Further, in the example of FIG. 7, a U-shaped frame 1 that rotates around a hollow shaft 107 around the patient treatment table.
05 is rotated to rotate the cyclotron 100 held by the U-shaped frame 105 around a shaft 111, by a gear 108 meshing with a hollow shaft 107 supported by a wall portion 106 and a gear concentrically provided. A two-dimensional irradiation device configured to transmit a rotational force to a cyclotron by a driven shaft 109 and a shaft 110 at one end of a U-shaped frame 105 is shown (see FIG. 9 of Prior Art 2 for details). And see the description).
【０００９】また，図８においては，３つの磁極片１２
１にターゲット装着ゾーン１２２を設けるとともに，こ
れらの磁極片１２１間に中性子線出口１２３を有する磁
性砕片１２４を設けており，ターゲット１２５を３個用
意し，３方から取り出せるように構成しているが，サイ
クロトロンの中心軸を患者の中心軸と平行にした図５又
は図７の装置装置（又は従来技術２の第１０図の装置）
と組み合わせることによって，２次元照射装置を構成す
る（詳しくは，従来技術２の第１２図参照）。このよう
に，従来技術２は，２次元的回転照射装置を示してい
る。Further, in FIG. 8, three magnetic pole pieces 12 are provided.
1 is provided with a target mounting zone 122, and magnetic debris 124 having a neutron beam outlet 123 is provided between these magnetic pole pieces 121, and three targets 125 are prepared so that they can be taken out from three directions. The device of FIG. 5 or 7 in which the central axis of the cyclotron is parallel to the central axis of the patient (or the device of FIG. 10 of Prior Art 2)
A two-dimensional irradiation device is configured by combining with (see FIG. 12 of Prior Art 2 for details). Thus, the related art 2 shows a two-dimensional rotary irradiation device.
【００１０】また，従来技術３においては，中性子照射
治療機械は，サイクロトロン加速器と患者を患者治療領
域に静止して支持するための患者テーブルと，サイクロ
トロンとの重量の釣り合いを保ちながら保持するととも
に，患者テーブル１７を保持するガントリーとを備えて
いる。また，サイクロトロン内には，ターゲットと中性
子コリメータが設けられている。このターゲットは第１
及び第２の物質により構成され，第１の物質は高エネル
ギー陽子で衝突されたとき，多量の高エネルギー中性子
を生じ，第２の物質は，低エネルギー陽子で衝撃された
とき，比較的少量の中性子を生じる。中性子コリメータ
は，ターゲットから発する中性子束のローブと一致し，
患者治療領域に照射された中性子ビームの断面積及び
（または）方向を変えるように調整可能に設けられてい
る。この中性子照射治療機械は，サイクロトロンがガン
トリーによって，患者を通る一軸の周りを回転するよう
になっている。In the prior art 3, the neutron irradiation treatment machine holds the cyclotron accelerator and the patient table for stationary support of the patient in the patient treatment area, while maintaining the weight balance between the cyclotron and the cyclotron. And a gantry for holding the patient table 17. A target and a neutron collimator are provided inside the cyclotron. This target is first
And a second material, the first material producing a large amount of high energy neutrons when bombarded with high energy protons, and the second material having a relatively small amount when bombarded with a low energy proton. Produces neutrons. The neutron collimator matches the lobe of the neutron flux emanating from the target,
It is adjustably arranged to change the cross-sectional area and / or the direction of the neutron beam applied to the patient treatment area. In this neutron irradiation treatment machine, a cyclotron is rotated by a gantry around an axis passing through a patient.
【００１１】[0011]
【発明が解決しようとする課題】Ｘ線や中性子線は，図
９に示すように，体表面から深部分に行くに従って線量
が減少する。したがって，必要線量を癌部位に照射する
ためには，体の表面近くでの照射線量が過大になること
は避け得ず，正常組織を傷めることがある。この問題
は，従来技術２の２次元的回転照射装置によりある程度
抑制が期待される。As shown in FIG. 9, the dose of X-rays and neutron rays decreases from the body surface to the deeper part. Therefore, in order to irradiate the cancerous site with the required dose, it is unavoidable that the irradiation dose near the surface of the body becomes excessive, which may damage normal tissues. It is expected that this problem will be suppressed to some extent by the two-dimensional rotary irradiation device of Prior Art 2.
【００１２】しかしながら，上述した２次元的回転照射
装置では，放射線の向きに偏りが生じ，例えば，図５の
装置においては，患部を通る患者の中心軸に平行な軸を
含む面内において，照射角度を変更することはできない
ので，癌部位に全部の方位から放射線を照射することが
できず，癌部位のみに大量の放射線を照射するために
は，依然として問題がある。However, in the above-described two-dimensional rotary irradiation device, the direction of radiation is biased, and for example, in the device of FIG. 5, irradiation is performed in a plane including an axis parallel to the central axis of the patient passing through the affected area. Since the angle cannot be changed, it is not possible to irradiate the cancer site from all directions, and there is still a problem in irradiating a large amount of radiation only to the cancer site.
【００１３】そこで，本発明の一技術的課題は，中性子
線をあらゆる方位から照射できるようにした３次元粒子
線照射装置を提供することにある。Therefore, a technical object of the present invention is to provide a three-dimensional particle beam irradiation apparatus capable of irradiating a neutron beam from all directions.
【００１４】さらに，本発明の他の技術的課題は，中性
子線による癌治療時，正常組織へのダメージを減少さ
せ，治療患部への線量集中の度合いを向上させることが
できる医用３次元中性子線照射装置を提供することにあ
る。Further, another technical problem of the present invention is that a medical three-dimensional neutron beam can reduce the damage to normal tissue and improve the degree of dose concentration to the treated affected area during cancer treatment by neutron rays. An object is to provide an irradiation device.
【００１５】[0015]
【課題を解決するための手段】本発明によれば，一軸上
の照射対象に向けて粒子線を出射する粒子線出射装置
と，前記一軸を中心として前記粒子線出射装置を公転さ
せる回転手段とを備えた粒子線照射装置において，前記
粒子線と前記一軸とでなす角度を変向させる照射角変向
手段を備え，前記照射対象に前記粒子線出射装置からの
粒子線を異なる様々な向きから入射させるようにしたこ
とを特徴とする３次元粒子線照射装置が得られる。According to the present invention, a particle beam emitting device for emitting a particle beam toward an irradiation target on one axis, and a rotating means for revolving the particle beam emitting device about the one axis. In the particle beam irradiation apparatus comprising: a particle beam irradiation means for changing the angle formed by the particle beam and the uniaxial, the particle beam from the particle beam emission device to the irradiation target from various different directions. A three-dimensional particle beam irradiation device characterized by being incident can be obtained.
【００１６】本発明によれば，前記３次元粒子線照射装
置において，前記照射角変動手段は，前記粒子線出射装
置と前記照射対象とを前記一軸に沿う方向に相対移動さ
せる相対移動手段と，前記相対移動手段による相対移動
に連動して前記粒子線の出射の向きを変向させる出射角
変向手段とを含むことを特徴とする３次元粒子線照射装
置が得られる。According to the present invention, in the three-dimensional particle beam irradiation apparatus, the irradiation angle changing means includes relative moving means for relatively moving the particle beam emitting apparatus and the irradiation target in a direction along the one axis. A three-dimensional particle beam irradiation apparatus is provided, which includes an emission angle changing means for changing the direction of emission of the particle beam in association with the relative movement by the relative movement means.
【００１７】本発明によれば，前記３次元粒子線照射装
置において，前記粒子線出射手段はサイクロトロンを含
み，前記出射角変動手段は，前記サイクロトロンの母粒
子の最終軌道上の互いに異なる角度の複数箇所のうちか
ら選んだ１箇所に配置されたターゲットと，前記母粒子
が前記ターゲットに衝突することで生成された娘粒子を
前記サイクロトロンの外部に引き出すために，前記複数
箇所に対応した複数の粒子線引出孔とを備えていること
を特徴とする３次元粒子線照射装置が得られる。According to the present invention, in the three-dimensional particle beam irradiation apparatus, the particle beam emitting means includes a cyclotron, and the emitting angle varying means has a plurality of different angles on a final trajectory of mother particles of the cyclotron. A target arranged at one location selected from the locations and a plurality of particles corresponding to the plurality of locations in order to draw out daughter particles generated by the mother particles colliding with the target to the outside of the cyclotron. A three-dimensional particle beam irradiation apparatus is provided, which is provided with a wire drawing hole.
【００１８】本発明によれば，前記３次元粒子線照射装
置において，前記出射角変動手段は，前記サイクロトロ
ンに結合されて前記粒子線を案内する粒子線案内手段を
備え，前記粒子線案内手段は，前記複数の粒子線引出孔
のうちの一つのみを開口させ，残りの粒子線引出孔を閉
塞するシールド部を含み，前記シールド部は前記サイク
ロトロンの母粒子の最終軌道に沿って可動なものである
ことを特徴とする３次元粒子線照射装置が得られる。According to the present invention, in the three-dimensional particle beam irradiation apparatus, the emission angle varying means includes particle beam guiding means coupled to the cyclotron for guiding the particle beam, and the particle beam guiding means is A shield part that opens only one of the plurality of particle beam extraction holes and closes the remaining particle beam extraction holes, the shield part being movable along the final trajectory of the mother particle of the cyclotron. A three-dimensional particle beam irradiation apparatus is obtained.
【００１９】本発明によれば，前記したいずれかの３次
元粒子線照射装置において，前記相対移動手段は，粒子
線照射装置又は前記照射対象を乗せる治療台て前記出射
角変向手段と連動して移動させる装置を有し，前記粒子
線は中性子線であることを特徴とする医用３次元中性子
照射装置が得られる。According to the present invention, in any one of the above-mentioned three-dimensional particle beam irradiation devices, the relative moving means is interlocked with the emission angle changing means as a particle beam irradiation device or a treatment table on which the irradiation target is placed. A three-dimensional medical neutron irradiation apparatus for medical use is obtained in which the particle beam is a neutron beam.
【００２０】[0020]
【作用】本発明においては，このように，粒子線出射装
置の一軸を中心としての公転と，粒子線との一軸とでな
す角度を変向することにより，照射対象に粒子線を異な
る様々な方向から入射させることが可能になる。即ち，
粒子線ビームの一軸に沿う方向での粒子線照射が可能と
なり，一軸回りに粒子線発生源を回転させる回転手段と
合わせて照射対象に粒子線を３次元照射することができ
る。In the present invention, as described above, by changing the angle formed by the revolution of the particle beam emitting device about one axis and the axis of the particle beam, it is possible to change the particle beam to various irradiation targets. It becomes possible to make it enter from a direction. That is,
Particle beam irradiation in a direction along one axis of the particle beam becomes possible, and the particle beam can be three-dimensionally irradiated to the irradiation target together with a rotating means for rotating the particle beam generation source around the axis.
【００２１】[0021]
【実施例】以下，本発明の実施例について説明する。本
発明の実施例では３次元粒子線照射装置として，癌治療
に用いられる医用３次元中性子照射装置を例示する。EXAMPLES Examples of the present invention will be described below. In the embodiment of the present invention, a medical three-dimensional neutron irradiation apparatus used for cancer treatment is exemplified as the three-dimensional particle beam irradiation apparatus.
【００２２】図１（ａ）及び（ｂ）は，本発明の実施例
に係る医用３次元中性子照射装置を示す平面図及び正面
断面図である。図１（ａ）及び（ｂ）を参照して，医用
３次元中性子照射装置１０は，母粒子として陽子又は重
陽子ビームを発生するとともに粒子線引出孔１ａ，１
ｂ，１ｃを有するサイクロトロン１と，このサイクロト
ロン１の最終引出軌道上に設けられ，その陽子ビームか
ら娘粒子である中性子を発生させる粒子線発生源とし
て，サイクロトロン１に対して脱着可能なターゲット
２，３，及び４と，サイクロトロン１からの中性子線を
案内する案内孔部５ａを有し粒子線案内手段として作用
するとともにコリメータを兼ね放射線から患者を守り，
治療台７と連動して相対移動可能なシールド部５と，サ
イクロトロン１を支持するとともに，このサイクロトロ
ン１からの出射ビーム方向を半径方向に常に保ちながら
ｚ軸回りに１８０°公転させる回転手段として回転機構
６と，相対移動手段として患者を乗せた状態でｚ軸方向
に相対移動可能な治療台７及び／又は治療台を固定（も
しくは可動）とし，サイクロトロン１（粒子線出射装
置）を回転機構６上で一軸方向に移動させる装置とを備
えている。FIGS. 1A and 1B are a plan view and a front sectional view showing a medical three-dimensional neutron irradiation apparatus according to an embodiment of the present invention. Referring to FIGS. 1A and 1B, a medical three-dimensional neutron irradiation apparatus 10 generates a proton or deuteron beam as a mother particle, and at the same time, a particle beam extraction hole 1a, 1
a cyclotron 1 having b and 1c, and a target 2 which is provided on the final extraction orbit of the cyclotron 1 and which emits neutrons, which are daughter particles, from its proton beam and which is detachable from the cyclotron 1. 3 and 4 and a guide hole 5a for guiding the neutron beam from the cyclotron 1, which functions as a particle beam guiding means and also serves as a collimator to protect the patient from radiation,
While supporting the cyclotron 1 and the shield part 5 that can move relatively in conjunction with the treatment table 7, the cyclotron 1 rotates as a rotating means that revolves 180 ° around the z axis while always keeping the direction of the beam emitted from the cyclotron 1 in the radial direction. The mechanism 6 and the treatment table 7 and / or the treatment table 7 which can be moved relative to each other in the z-axis direction as a relative movement means are fixed (or movable), and the cyclotron 1 (particle beam emitting device) is rotated by the rotation mechanism 6. And a device for moving the above in a uniaxial direction.
【００２３】ここで，本発明いう粒子線出射装置はサイ
クロトロン１を含んで構成されている。また，照射角変
向手段は，粒子線出射装置であるサイクロトロン１と，
照射対象である患者の患部とを，ｚ軸方向に移動させる
治療台７とサイクロトロン１との相対移動に連動して，
粒子線の出射向きを変向させる出射角変向手段としてタ
ーゲット２，３，及び４を備えている。Here, the particle beam emitting apparatus according to the present invention is configured to include the cyclotron 1. Also, the irradiation angle changing means is a cyclotron 1 which is a particle beam emitting device,
In conjunction with the relative movement between the treatment table 7 and the cyclotron 1 for moving the affected part of the patient to be irradiated in the z-axis direction,
Targets 2, 3, and 4 are provided as emitting angle changing means for changing the emitting direction of the particle beam.
【００２４】回転機構６は，サイクロンを支持する支持
部６ａと，サイクロトロン１とｚ軸の回りのバランスを
取るために，対向位置にカウンタバランスウエイト６ａ
とが設けられ，これらは回転部６ｃにより，ｚ軸回りに
回転可能に設けられている。The rotation mechanism 6 is provided with a counter balance weight 6a at a facing position in order to balance the support portion 6a for supporting the cyclone and the cyclotron 1 and the z axis.
And are provided so as to be rotatable about the z-axis by the rotating unit 6c.
【００２５】また，シルード部５は，固定部に設けられ
た伸縮可能なロッドを有するシールド部移動機構１２に
より，サイクロトロン１と同心的に回動し，ターゲット
２，３，及び４の位置設定に基づいて，夫々の粒子線引
出孔１ａ，１ｂ，１ｃと案内孔部５ａとが一致するよう
に予め定められた位置に設定される。Further, the shield part 5 is rotated concentrically with the cyclotron 1 by a shield part moving mechanism 12 having an expandable and contractible rod provided in the fixed part to set the positions of the targets 2, 3, and 4. Based on this, the particle beam extraction holes 1a, 1b, 1c and the guide hole portion 5a are set at predetermined positions so as to coincide with each other.
【００２６】この医用３次元中性子照射装置は，サイク
ロトロン１を回転機構６によって，患者の周りを回転さ
せ，２次元的に中性子を照射することができる。更に，
この装置は，サイクロトロン１の最終引出軌道上に出し
入れ可能なターゲット２，３，４を３式取り付け，か
つ，患者とサイクロトロン１と治療台７をｚ軸方向に相
対移動させることにより３次元照射を行うことができ
る。本発明において，中性子発生源とは，サイクロトロ
ン１に設けられたターゲット２，３，及び４を呼ぶ。In this medical three-dimensional neutron irradiation device, the cyclotron 1 can be rotated around the patient by the rotating mechanism 6 and two-dimensionally irradiated with neutrons. Furthermore,
This device is equipped with three sets of targets 2, 3 and 4 that can be taken in and out on the final withdrawal orbit of the cyclotron 1, and the patient, the cyclotron 1 and the treatment table 7 are relatively moved in the z-axis direction for three-dimensional irradiation. It can be carried out. In the present invention, the neutron source refers to the targets 2, 3, and 4 provided in the cyclotron 1.
【００２７】図２（ａ），（ｂ），及び（ｃ）は，図１
（ａ）及び（ｂ）の医用３次元中性子照射装置のターゲ
ット動作を示す図である。図２（ａ）において，ターゲ
ット３はサイクロトロン１の最終引出軌道上でターゲッ
ト面の法線の治療台７方向に対する角度θが９０°をな
す位置に設定されている。また，シールド部５は，シー
ルド部移動機構１２によって，シールド部５に設けられ
た案内孔部５ａが粒子線引出孔１ａと重なり合い，粒子
線引出孔１ｂ，１ｃを遮蔽するように移動設定されてい
る。ターゲットから発生した中性子ビームは，粒子線引
出孔１ａ及び案内孔部５ａを介して，鉛直方向に患者８
の患部２１に照射される。2A, 2B, and 2C are shown in FIG.
It is a figure which shows the target operation | movement of the medical three-dimensional neutron irradiation apparatus of (a) and (b). In FIG. 2A, the target 3 is set at a position where the angle θ of the normal line of the target surface to the treatment table 7 direction is 90 ° on the final drawing orbit of the cyclotron 1. Further, the shield part 5 is moved and set by the shield part moving mechanism 12 so that the guide hole part 5a provided in the shield part 5 overlaps the particle beam drawing hole 1a and blocks the particle beam drawing holes 1b and 1c. There is. The neutron beam generated from the target passes through the particle beam extraction hole 1a and the guide hole portion 5a and moves vertically to the patient 8
The affected area 21 is irradiated.
【００２８】図２（ｂ）においては，ターゲット３はサ
イクロトロン１の最終引出軌道上でターゲット３面の法
線の治療台７に対する角度θが６０度をなす位置に，シ
ールド部移動機構１２によって移動され設定されてい
る。また，シールド部５に設けられた案内孔部５ａは，
粒子線引出孔１ｂと重なり合うように設定されている。
そして，治療台７は，このターゲット３及びシールド部
５の移動に対応して，図示しない移動手段により水平方
向に移動され（図では左方向），予め定められた位置に
設定されている。ターゲット３から発生した中性子ビー
ムは，粒子線引出孔１ｂ及び案内孔部５ａを介して，水
平方向に対して６０°をなす方向に照射され，予め定め
られ位置に置かれた患者８の患部２１に入射する。In FIG. 2B, the target 3 is moved by the shield moving mechanism 12 to a position where the angle θ of the normal line of the target 3 surface to the treatment table 7 is 60 degrees on the final drawing orbit of the cyclotron 1. And is set. In addition, the guide hole portion 5a provided in the shield portion 5 is
It is set so as to overlap with the particle beam extraction hole 1b.
Then, the treatment table 7 is moved in the horizontal direction by the moving means (not shown) in correspondence with the movement of the target 3 and the shield portion 5 (leftward in the figure), and is set at a predetermined position. The neutron beam generated from the target 3 is irradiated through the particle beam extraction hole 1b and the guide hole portion 5a in a direction forming an angle of 60 ° with respect to the horizontal direction, and the affected area 21 of the patient 8 placed at a predetermined position. Incident on.
【００２９】図２（ｃ）においては，ターゲット４はサ
イクロトロン１の最終引出軌道上でターゲット面の法線
の治療台７に対する角度θが１２０をなす位置に，シー
ルド部移動機構１２によって移動設定されている。ま
た，シールド部５に設けられた案内孔部５ａは，粒子線
引出孔１ｃと重なり合うように設定されている。そし
て，このターゲット及びシールド部５の移動に対応して
治療台７は図示しない移動手段により水平方向に移動さ
れ（図では，右方向），予め定められた位置に設定され
る。ターゲット３から発生した中性子ビームは，粒子線
引出孔１ｂ及び案内孔部５ａを介して，水平方向に対し
て６０°をなす方向に照射され，予め定められ位置に置
かれた患者８の患部２１に入射する。In FIG. 2C, the target 4 is moved and set by the shield moving mechanism 12 to a position where the angle θ of the normal line of the target surface with respect to the treatment table 7 is 120 on the final drawing orbit of the cyclotron 1. ing. The guide hole portion 5a provided in the shield portion 5 is set so as to overlap with the particle beam drawing hole 1c. Then, in response to the movement of the target and the shield portion 5, the treatment table 7 is horizontally moved (rightward in the figure) by a moving means (not shown) and set at a predetermined position. The neutron beam generated from the target 3 is irradiated through the particle beam extraction hole 1b and the guide hole portion 5a in a direction forming an angle of 60 ° with respect to the horizontal direction, and the affected area 21 of the patient 8 placed at a predetermined position. Incident on.
【００３０】このように，中性子発生装置が患者の回り
１８０°回転（２次元）することに加えて，ｚ軸方向も
含めた３次元照射は，ターゲット位置を２，３，４で示
す数箇所設置し，ビームの方向を変えることにより可能
となる。As described above, in addition to the neutron generator rotating 180 degrees around the patient (two-dimensional), three-dimensional irradiation including the z-axis direction is performed at several target positions indicated by 2, 3 and 4. This can be done by installing and changing the beam direction.
【００３１】この３次元照射は，患者の体表面ではな
く，深部に発生した癌に対しては，表面から深部までの
正常組織への中性子照射を極力低減するため方向を変え
て多数回照射を行う。This three-dimensional irradiation is applied to the cancer that has occurred not in the surface of the patient's body but in the deep part, by changing the direction and irradiating a large number of times to reduce the neutron irradiation to the normal tissue from the surface to the deep part as much as possible. To do.
【００３２】図３は２次元照射を行うことの利点の説明
に供する概略図である。図３において，矢印２２，２
３，２４，２５，２６，及び２７で示すように，患部に
対して６方向から均等に照射を考えた場合，患部（中
心）を２１とすると，部分３１は１／６の線量，部分３
２は２／６，部分３３は３／６，部分３４は４／６，部
分３５は５／６，部分３６は６／６となり，表面３１
は，患部２１の１／６の線量となり，２次元照射では重
なりが大きくなり，６方向からの照射が限度であるが，
本発明の装置では，このように，照射角を３次元的に変
向させることによって，２次元的に中性子線を照射した
場合に比較して，正常組織部に照射する線量を分散さ
せ，患部に集中して照射できるので，正常組織へのダメ
ージを減少させることができる点で極めて有利となる。
特に，図１及び図２に示す装置では３方向に照射角を変
向させる構成について例示したが，図３のように，ター
ゲット及び粒子線取出孔を更に設けて，６方向或いはそ
れ以上に照射角を変向できるように構成することもでき
る。FIG. 3 is a schematic diagram for explaining the advantages of performing two-dimensional irradiation. In FIG. 3, arrows 22, 2
As shown by 3, 24, 25, 26, and 27, when the affected area is considered to be uniformly irradiated from 6 directions, when the affected area (center) is 21, the portion 31 has a dose of 1/6, and the portion 3 has
2 is 2/6, part 33 is 3/6, part 34 is 4/6, part 35 is 5/6, part 36 is 6/6, and the surface 31
Is 1/6 of the dose of the affected part 21, and the overlap becomes large in two-dimensional irradiation, and irradiation from 6 directions is limited,
In the apparatus of the present invention, by changing the irradiation angle three-dimensionally in this way, compared with the case where two-dimensional irradiation of neutron rays is performed, the dose to be irradiated to the normal tissue part is dispersed and the affected part is affected. Since the irradiation can be concentrated on the tissue, it is extremely advantageous in that damage to normal tissue can be reduced.
In particular, the apparatus shown in FIGS. 1 and 2 has exemplified the configuration in which the irradiation angle is changed in three directions. However, as shown in FIG. 3, a target and a particle beam extraction hole are further provided to irradiate in six directions or more. It can be configured so that the corner can be turned.
【００３３】図４は１５方向照射を行った場合の体表面
の患部からの位置におけるより現実に近い形で計算した
線量分布を示す図である。図４においては，体表面から
１０ｃｍ深部癌を想定して作成されている。この図で示
すように，患部において最大となり，体表面の部位はそ
の数十分の１の線量分布となり，患者への負担が相当軽
減していることが分かる。FIG. 4 is a diagram showing a dose distribution calculated in a more realistic form at a position from the affected area on the body surface when irradiation in 15 directions is performed. In FIG. 4, it is created assuming a cancer 10 cm deep from the body surface. As shown in this figure, it can be seen that the dose is maximized in the affected area and the dose distribution on the surface of the body is tens of minutes, and the burden on the patient is considerably reduced.
【００３４】[0034]
【発明の効果】以上説明したように，本発明によれば，
小型で安価な３次元粒子線照射装置を提供することがで
きる。As described above, according to the present invention,
It is possible to provide a small and inexpensive three-dimensional particle beam irradiation apparatus.
【００３５】また，本発明によれば，中性子線による癌
治療時，正常組織へのダメージを減少させ，治療患部へ
の線量集中の度合いを向上させることができる医用３次
元中性子照射装置を提供することができる。Further, according to the present invention, there is provided a medical three-dimensional neutron irradiation apparatus capable of reducing the damage to normal tissue and improving the degree of dose concentration to the affected area during cancer treatment by neutron rays. be able to.
【図１】（ａ）は本発明の実施例に係る医用３次元中性
子照射装置を示す平面図である。（ｂ）は（ａ）の医用
３次元中性子照射装置の正面断面図である。FIG. 1A is a plan view showing a medical three-dimensional neutron irradiation apparatus according to an embodiment of the present invention. (B) is a front sectional view of the medical three-dimensional neutron irradiation apparatus of (a).
【図２】（ａ），（ｂ），及び（ｃ）は，図１（ａ）及
び（ｂ）の医用３次元中性子照射装置のターゲット動作
説明に供する図である。2 (a), (b), and (c) are diagrams for explaining a target operation of the medical three-dimensional neutron irradiation apparatus of FIGS. 1 (a) and 1 (b).
【図３】３次元照射を多数回に分けて行う場合を概略的
に示す図である。FIG. 3 is a diagram schematically showing a case where three-dimensional irradiation is performed in multiple times.
【図４】体表面の患部からの位置における線量分布を示
す図である。FIG. 4 is a diagram showing a dose distribution at a position on the body surface from an affected part.
【図５】従来の中性子照射装置の一部の一例を示す正面
図である。FIG. 5 is a front view showing an example of a part of a conventional neutron irradiation apparatus.
【図６】従来の中性子照射装置の一部の他の例を示す正
面図である。FIG. 6 is a front view showing another example of a part of a conventional neutron irradiation apparatus.
【図７】従来の中性子照射装置の一部の更に他の例を示
す正面図である。FIG. 7 is a front view showing still another example of a part of a conventional neutron irradiation apparatus.
【図８】従来の中性子照射装置の一部の別の例を示す正
面図である。FIG. 8 is a front view showing another example of a part of a conventional neutron irradiation apparatus.
【図９】粒子線と他の放射線との相違の説明に供する図
である。FIG. 9 is a diagram for explaining a difference between a particle beam and another radiation.
１ サイクロトロン １ａ，１ｂ，１ｃ 粒子線引出孔 ２，３，４ ターゲット ５ シールド部 ５ａ 案内孔部 ６ 回転機構 ７ 治療台 ８ 患者 １０ 医用３次元中性子照射装置 １２ シールド部移動機構 ２１ 患部 ２２，２３，２４，２５，２６，２７ 矢印 1 cyclotron 1a, 1b, 1c particle beam extraction hole 2, 3, 4 target 5 shield part 5a guide hole part 6 rotation mechanism 7 treatment table 8 patient 10 medical three-dimensional neutron irradiation device 12 shield part moving mechanism 21 affected part 22, 23, 24, 25, 26, 27 arrows
───────────────────────────────────────────────────── フロントページの続き (72)発明者 曽我 文宣 千葉県千葉市稲毛区穴川４丁目９番１号 放射線医学総合研究所内 (72)発明者 館野 之男 千葉県千葉市稲毛区穴川４丁目９番１号 放射線医学総合研究所内 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Fuminobu Soga, 4-9-1, Anagawa, Inage-ku, Chiba, Chiba, Japan Research Institute for Radiation Medicine (72) Norio Tateno, 4-9, Anagawa, Inage-ku, Chiba, Japan No. 1 within the Institute of Radiological Medicine
Claims (6)
する粒子線出射装置と，前記一軸を中心として前記粒子
線出射装置を公転させる回転手段とを備えた粒子線照射
装置において，前記粒子線と前記一軸とでなす角度を変
向させる照射角変向手段を備え，前記照射対象に前記粒
子線出射装置からの粒子線を異なる様々な向きから入射
させるようにしたことを特徴とする３次元粒子線照射装
置。1. A particle beam irradiation apparatus comprising: a particle beam emitting device for emitting a particle beam toward an irradiation target on one axis; and a rotating means for revolving the particle beam emitting device about the one axis. An irradiation angle changing means for changing the angle formed by the particle beam and the one axis is provided, and the particle beam from the particle beam emitting device is made to enter the irradiation target from various different directions. Three-dimensional particle beam irradiation device.
おいて，前記照射角変向手段は，前記粒子線出射装置と
前記照射対象とを前記一軸に沿う方向に相対移動させる
相対移動手段と，前記相対移動手段による相対移動に連
動して前記粒子線の出射の向きを変向させる出射角変向
手段とを含むことを特徴とする３次元粒子線照射装置。2. The three-dimensional particle beam irradiation apparatus according to claim 1, wherein the irradiation angle changing means includes relative movement means for relatively moving the particle beam emitting apparatus and the irradiation target in a direction along the one axis. A three-dimensional particle beam irradiation device, comprising: an emission angle changing means for changing the direction of emission of the particle beam in association with the relative movement by the relative movement means.
おいて，前記粒子線出射手段はサイクロトロンを含み，
前記出射角変向手段は，前記サイクロトロンの母粒子の
最終軌道上の互いに異なる角度の複数箇所のうちから選
んだ１箇所に配置されたターゲットと，前記母粒子が前
記ターゲットに衝突することで生成された娘粒子を前記
サイクロトロンの外部に引き出すために，前記複数箇所
に対応した複数の粒子線引出孔とを備えていることを特
徴とする３次元粒子線照射装置。3. The three-dimensional particle beam irradiation apparatus according to claim 2, wherein the particle beam emitting means includes a cyclotron,
The exit angle changing means is generated by a target arranged at one location selected from a plurality of locations on the final orbit of the mother particle of the cyclotron at mutually different angles, and the mother particle colliding with the target. A three-dimensional particle beam irradiation apparatus, comprising: a plurality of particle beam extraction holes corresponding to the plurality of positions, in order to extract the formed daughter particles to the outside of the cyclotron.
おいて，前記出射角変向手段は，前記サイクロトロンに
結合されて前記粒子線を案内する粒子線案内手段を備
え，前記粒子線案内手段は，前記複数の粒子線引出孔の
うちの一つのみを開口させ，残りの粒子線引出孔を閉塞
するシールド部を含み，前記シールド部は前記サイクロ
トロンの母粒子の最終軌道に沿って可動なものであるこ
とを特徴とする３次元粒子線照射装置。4. The three-dimensional particle beam irradiation apparatus according to claim 3, wherein the emitting angle changing means includes particle beam guiding means coupled to the cyclotron to guide the particle beam, and the particle beam guiding means. Includes a shield part that opens only one of the plurality of particle beam extraction holes and closes the remaining particle beam extraction holes, and the shield part is movable along the final trajectory of the mother particle of the cyclotron. A three-dimensional particle beam irradiation apparatus characterized by being a thing.
３次元粒子線照射装置において，前記相対移動手段は前
記照射対象を乗せて前記出射角変向手段と連動して前記
粒子線の照射位置に移動させる治療台を含み，前記粒子
線は中性子線であることを特徴とする医用３次元中性子
照射装置。5. The three-dimensional particle beam irradiation apparatus according to any one of claims 2 to 4, wherein the relative moving means places the irradiation target on the particle beam in conjunction with the emission angle changing means. The medical three-dimensional neutron irradiation apparatus including a treatment table for moving the particle beam to the irradiation position, and the particle beam is a neutron beam.
３次元粒子線照射装置において，前記相対移動手段は，
前記粒子線出射装置を前記出射角変向手段と連動して一
軸方向に移動させる装置を有し，前記粒子線は中性子線
であることを特徴とする医用３次元中性子照射装置。6. The three-dimensional particle beam irradiation apparatus according to claim 2, wherein the relative moving means comprises:
A medical three-dimensional neutron irradiation apparatus having a device for moving the particle beam emitting device in a uniaxial direction in conjunction with the emitting angle changing means, wherein the particle beam is a neutron beam.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP06048198A JP3079346B2 (en) | 1994-03-18 | 1994-03-18 | 3D particle beam irradiation equipment |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP06048198A JP3079346B2 (en) | 1994-03-18 | 1994-03-18 | 3D particle beam irradiation equipment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH07255867A true JPH07255867A (en) | 1995-10-09 |
| JP3079346B2 JP3079346B2 (en) | 2000-08-21 |
Family
ID=12796693
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP06048198A Expired - Fee Related JP3079346B2 (en) | 1994-03-18 | 1994-03-18 | 3D particle beam irradiation equipment |
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| Country | Link |
|---|---|
| JP (1) | JP3079346B2 (en) |
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