JPH07244045A - Stool occult blood examination appliance - Google Patents

Abstract

PURPOSE:To obtain a stool occult blood examination appliance based on immunological stool occult blood reaction capable of simply judging the presence of stool occult blood without requiring sufficient skill. CONSTITUTION:The stool occult blood examination appliance 1 is equipped with a compressible container 2 having a stool dissolving soln. 6 received therein and capable of being compressed by a finger and the reaction container 2 attached to the compressible container 2 in a freely detachable manner. A stool sampling jig main body 5 is integrated with the reaction container 3 and a stool sampling part 5a for sampling a stool specimen, an inflow port 5b for a stool specimen soln., an internal passage 5c and a dripping port 5d dripping the stool specimen soln. are provided to the stool sampling jig main body 5 and a filter 8 for removing an unnecessary solid is arranged to the internal passage 5c and an anti-human hemoglobin sensitizing reagent 9 is fixed to the bottom part of the reaction container 3.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a fecal occult blood test apparatus utilizing an immunological fecal occult blood reaction, and more particularly to a fecal occult blood test apparatus capable of easily screening for abnormalities in the digestive system and the like.

[0002]

2. Description of the Related Art In clinical tests, stool and urine are often used as test samples in addition to blood. Among them, the detection of fecal occult blood is known to be very effective for early detection of digestive system diseases represented by cancer and ulcer.

The methods for detecting fecal occult blood are roughly classified as follows.
There are a chemical fecal occult blood reaction method and an immunological fecal occult blood reaction method. The chemical fecal occult blood reaction method utilizes the color development of a chromogen based on the peroxidase activity of heme contained in hemoglobin, and has the advantage that it has high sensitivity and can detect even a small amount of hemoglobin. . However, since the chemical fecal occult blood test does not have specificity for human hemoglobin and also reacts with animal hemoglobin, subjects must perform strict dietary restrictions before the test. There was a drawback.

On the other hand, the immunological fecal occult blood reaction method is
It utilizes an antigen-antibody reaction using an anti-human hemoglobin antibody. The immunological fecal occult blood reaction method is more specific than the chemical fecal occult blood reaction method, and does not require the above-mentioned dietary restrictions. Judgment is usually based on immunoserologic testing, but the method most utilized today is the latex agglutination method.

The latex agglutination method is a judgment method for diagnosing the formed agglutination image by mixing a stool solution and a latex reagent on a judgment plate. In detecting fecal occult blood by the latex agglutination method, first, an appropriate amount of feces is collected, and the collected feces are dissolved in a liquid such as physiological saline to obtain a fecal dissolution solution. Since the undigested solid content in the stool remains in this stool solution, an operation for removing the solid content is necessary. Various methods and devices have been conventionally proposed for collecting these feces and removing solids. For example, the actual Kaisho 61
No. 102941 and Japanese Utility Model Laid-Open No. 1-158964 disclose instruments for quantitatively collecting stool and the like, and Japanese Utility Model Laid-Open No. 2-21557 and Japanese Utility Model Laid-Open No. 2-14.
Japanese Patent No. 0468 and Japanese Utility Model Publication No. 2-13977 disclose an instrument or a device for obtaining a fecal solution from which solids have been removed.

As described above, in order to test fecal occult blood by the latex agglutination method, the above-mentioned operation is required to obtain a fecal lysate from which solids have been removed. Is proposed.

However, there is a drawback that skill is required to judge the reaction of aggregation. In addition to the above operations,
A simple test device capable of completing the detection of fecal occult blood by mixing the obtained fecal lysate and the determination reagent has not been developed at present, and the system configuration was complicated.

[0008]

SUMMARY OF THE INVENTION An object of the present invention is a fecal occult blood test apparatus based on an immunological fecal occult blood reaction, in which stools are collected and a stool lysate solution from which undigested solids are removed and An object of the present invention is to provide a device that enables a series of operations up to detection of fecal occult blood using a determination reagent to be performed easily without requiring much skill.

[0009]

The fecal occult blood test apparatus of the present invention is an apparatus for determining fecal occult blood, which has an opening and is for dissolving a stool sample to prepare a stool sample solution. A stool solution is stored inside, and a compression container made of a compressible flexible material, and detachably attached to the compression container so as to close the opening of the compression container,
And a reaction container in which an anti-human hemoglobin antibody sensitizing reagent is fixed, and the reaction container is integrally formed with the reaction container, and in a state where the reaction container is attached to the compression container, a stool sample solution extending into the compression container The stool sample solution preparation unit includes a preparation unit and a stool sample solution dropping unit extending into the reaction container, and the stool sample solution preparation unit is provided on the outer surface and is used for collecting stool. A stool collection part and an inflow port into which the stool sample solution flows are formed, a stool sample solution dropping part is formed with a dripping port for dropping the stool sample solution, and the stool sampling device body is provided with A fecal occult blood test apparatus in which an internal channel connecting the inflow port and the drip port is provided, and a filter for removing solids in a fecal sample solution is disposed in the internal channel is there.

Preferably, a cover member is further provided so as to cover the compression container and detachably attached to the compression container.
This cover member is made of a material having higher rigidity than that of the compression container. Therefore, by attaching the cover member to the compression container, it is ensured that the compression container is compressed by a finger or the like when not desired. To be prevented.

As is apparent from the above structure, the fecal occult blood test apparatus of the present invention is a fecal occult blood test apparatus utilizing an immunological fecal occult blood reaction using an anti-human hemoglobin antibody sensitizing reagent.

In the fecal occult blood test apparatus of the present invention, the main body of the stool collection device having the stool collection part for collecting stool and the reaction container for carrying out the immunological reaction are integrated, and this reaction is performed. It is composed of a container and a compression container that is detachably attached to the reaction container, and makes it possible to easily perform from the collection of feces to the detection of fecal occult blood without using other reagents or instruments. Is.

A specific structural example of the fecal occult blood test apparatus of the present invention will be described below with reference to the drawings. 1 and 2 are a sectional view and a front view showing a preferred example of the fecal occult blood test apparatus of the present invention.

The fecal occult blood test apparatus 1 according to the present structural example comprises a compression container 2, a reaction container 3, and a cover member 4. The compression container 2 is closed so that the upper end has a hemispherical curved surface, and is composed of a cylindrical member having an opening at the bottom. As will be described later, the compression container 2 is made of a flexible material capable of compressing the internal space by pressing the side wall with a finger or the like. As such a material, a material having flexibility that enables the above-described compression work, such as a synthetic resin, is used. Examples of synthetic resins that can be used include celluloid, cellulose acetate, polyethylene, polypropylene, vinyl chloride resin, polystyrene, methacrylic resin, polyamide resin,
Examples include thermoplastic resins such as polycarbonate, polyether, and fluororesin, and thermosetting resins such as phenol resin, urea resin, melamine resin, furan resin, aniline resin, silicon resin, unsaturated polyester resin, and epoxy resin. It is preferable to use polyethylene, polypropylene, vinyl chloride resin, polystyrene, acrylic resin or the like that is inexpensive and can be easily molded.

In the vicinity of the lower end opening of the compression container 2, a female screw 2a is formed on the inner surface, while a male screw 2b is formed on the outer surface. The female screw 2a is used to attach the reaction container 3 to the compression container 2 in a detachable manner.
Are provided for detachably attaching the cover member 4 to the compression container 2.

Further, the compression container 2 contains a stool solution 6 for dissolving a stool sample to prepare a stool sample solution. As the stool solution 6, physiological saline or various buffer solutions can be used, but any liquid can be used as long as it does not contain a substance that affects the fecal occult blood test. Usually, a buffer solution composed of a neutral salt solution which is generally used as an immunoreagent, for example, Maruzen Publishing, Experimental Chemistry Course No. 24.
Glycine buffer solution, phosphate buffer solution, ammonia buffer solution, Tris buffer solution and the like as described in Vol. 224, page 224 (1958) are used. The pH of these buffers is preferably in the range of 6.5 to 8.5 so that the reaction using the anti-human hemoglobin antibody sensitizing reagent can be suitably performed. pH
Can be adjusted by adding a base such as NaOH or an acid such as HCl.

The storage amount of the stool solution 6 is as follows.
Usually, it is about 1 to 10 ml. This range is not particularly limited, but if it is less than 1 ml, the work of determining fecal occult blood becomes difficult, and even if it exceeds 10 ml, the accuracy of determination is not so high and the container becomes large.

The reaction vessel 3 is a bottomed cylindrical vessel having an opening at the upper end. The material forming the reaction vessel 3 is not particularly limited, and may be an appropriate material such as synthetic resin, glass or metal. Preferably, the reaction vessel 3 is made of a transparent material, for example, transparent glass or synthetic resin, in order to make it easy to observe the internal state from the outside. The reaction vessel 3 is preferably composed of a synthetic resin that can be easily molded. Examples of the synthetic resin that can be used include celluloid, cellulose acetate, polyethylene, vinyl chloride resin, polypropylene, polystyrene, methacrylic resin, polyamide resin, Examples include thermoplastic resins such as polycarbonate, polyether, and fluororesin, and thermosetting resins such as phenol resin, urea resin, melamine resin, furan resin, aniline resin, silicon resin, unsaturated polyester resin, or epoxy resin. Inexpensive, easily moldable polyethylene, polypropylene, vinyl chloride resin,
It is preferable to use polystyrene or acrylic resin.

A male screw 3a is formed on the outer surface around the upper end of the reaction vessel 3. The male screw 3a is provided for detachably attaching the reaction container 3 to the compression container 2, and is screwed to the female screw 2a described above.

Further, the stool collection instrument body 5 is fixed and integrated with the reaction container 3 so as to close the upper end opening of the reaction container 3. In this structural example, the stool collection instrument body 5 is fixed and integrated with the reaction container 3, but if possible,
At least a part or all of the stool collection instrument body 5 may be formed integrally with the reaction container 3.

The stool collection instrument body 5 may be detachably attached to the reaction container 3. As shown in FIGS. 1 and 3, the stool collection device body 5 is provided with a stool collection part 5a on the upper end side. In the stool collection part 5a, a plurality of protrusions 7 are formed on the outer surface. This protrusion 7 is the body 5 of the stool collection device.
Is provided to catch a predetermined amount of stool on the side surface of the projection 7 when excavating the stool into the stool and pulling out from the stool.

In this structural example, the plurality of projections 7 are formed on the fecal sampling portion 5a.
However, as shown in FIG. 5A, the stool collection part 5a may be formed by forming a plurality of protrusions 7 at different height positions.

Further, although the projection 7 is provided for collecting stool, the structure for collecting a predetermined amount of stool sample from feces is not limited to the projection 7 as described above. You may form the recessed part 17 as shown to 5 (b).

Further, the plane shape, cross-sectional shape, height, depth or number of the projections 7 and the recesses 17 described above can be appropriately changed depending on the amount and nature of the feces to be collected.

Further, as shown in FIG. 1, in this structural example,
Although the stool collection part 5a is formed on the upper end side of the stool collection device body 5, the position where the stool collection part 5a is formed is not limited to this. That is, as shown in FIG. 1, in the state where the reaction container 3 is attached to the compression container 2, the above-mentioned stool collection part 5a is placed at an appropriate position in the part of the body 5 of the stool collection device which is inserted into the compression container 2. Can be formed.

However, preferably, before the stool sample is dissolved by the stool solution 6, the stool sample does not close the inflow port 5b, which will be described later, as in the present structural example. It is preferable to provide the stool collection part 5a at a position separated by a certain distance.

A plurality of inflow ports 5b are formed in the stool collection device body 5, and the inflow ports 5b are connected to an internal flow path 5c provided inside the stool collection device body 5. The internal flow path 5c is formed so as to reach the drip port 5d provided at the lower end.

The inflow port 5b is provided for inflowing a stool sample solution prepared by dissolving the stool sample in the stool solution 6, and a plurality of inflow ports 5b are provided as in the present structural example. However, only one inflow port 5b may be provided.

The internal flow path 5c is provided to guide the stool sample solution flowing in from the inflow port 5b to the dropping port 5d. Therefore, the reaction container 3 is attached to the compression container 2. In this state, the position of the inflow port 5b is determined so that the inflow port 5b is located inside the compression container 2. On the other hand, the position of the drip opening 5d is determined so that it can be located in the reaction vessel 3, and it is not always necessary to provide the drip opening 5d at the lower end as in this structural example. Further, a plurality of dropping ports may be formed so as to be positioned inside the reaction container 3.

A filter 8 is arranged in the middle of the internal flow path 5c. The filter 8 is provided to remove solids that are not dissolved in the stool sample solution. The material forming the filter 8 may be an appropriate porous substance as long as the solid content in the stool sample solution as described above can be removed. As such a porous material, for example, a porous material such as sponge or filter paper,
Alternatively, fibrous substances such as glass wool and absorbent cotton can be used. Examples of the material include materials made of cellulosic materials such as nitrocellulose and cellulose acetate, and synthetic polymer materials such as polyamide resin, fluororesin, polypropylene and polyvinylidene halide. In addition, the average pore size of the porous substance is, in order to remove the solid content in the stool sample solution,
It is preferably about 0.1 to 2 μm.

In this structural example, the filter 8 is the reaction container 3
The filter 8 is provided in the vicinity of the upper end of the inside of the reaction container 3, but the position where the filter 8 is arranged is at the inlet 5
It can be at any position between b and the drip port 5d. That is, above the position shown in FIG.
Alternatively, the filter 8 may be arranged below.

The main body 5 of the stool collection equipment except for the filter 8 is
As long as it has the above structure, it can be made of an appropriate material such as a synthetic resin or a metal, but it is preferably made of a synthetic resin from the viewpoint of ease of molding. As the synthetic resin that can be used, the synthetic resin materials exemplified for forming the reaction container 3 described above can be used.

The projection 7 may be formed by molding the stool collection device body 5 and then fixing synthetic resin or metal, but is preferably formed at the same time as the stool collection device body 5. Therefore, it can be easily configured.

An anti-human hemoglobin antibody sensitizing reagent 9 is fixed to the bottom of the reaction vessel 3. The anti-human hemoglobin sensitizing reagent 9 is prepared by sensitizing a carrier with an anti-human hemoglobin antibody. As the carrier, colloidal gold particles, silica particles, bentonite particles, etc. can be used. Considering the easiness and the antibody sensitization property, it is preferable to use synthetic resin latex particles, particularly polystyrene latex particles. Furthermore, it is preferable to use colored latex particles.

The anti-human hemoglobin antibody can be sensitized to the carrier by using a known antibody sensitization technique such as a physical adsorption method or a chemical adsorption method. For example, 1% by weight of latex is mixed with an anti-human hemoglobin antibody buffer solution,
By stirring at 37 ° C for 1 to 2 hours, the anti-human hemoglobin antibody can be physically adsorbed on the surface of the latex particles.

It is also possible to chemically adsorb the anti-human hemoglobin antibody via a covalent bond by performing the same operation using a latex having a carboxyl group on the surface.

The immobilization of the reagent in the reaction vessel 3 is carried out by dropping an anti-human hemoglobin antibody sensitizing reagent at room temperature for 12 to 24 hours.
It can be performed by drying for an hour. In this case, if a polysaccharide such as cellulose, hemicellulose or pectin is mixed with a reagent and dried to form a film, the reagent can be prevented from scattering. Therefore, the anti-human hemoglobin antibody sensitizing reagent can be more completely immobilized. An appropriate amount of the anti-human hemoglobin sensitizing reagent is about 20 to 50 μl in terms of a 1% by weight solution determination reagent in the present inspection apparatus. If the amount of the reagent is less than this, it becomes difficult to determine fecal occult blood with sufficient certainty, and if more than 50 μl is used, the economical efficiency is reduced.

A cover member 4 is attached so as to cover the outside of the compression container 2. The cover member 4 is closed at the upper end and has an opening at the lower end. A female screw 4a is formed on the inner surface in the vicinity of this opening. The female screw 4 a is formed so as to be screwed into the male screw 2 b of the compression container 2, and thereby the cover member 4 is detachable from the compression container 2.

The cover member 4 can be made of an appropriate material such as glass, metal or synthetic resin.
As will be apparent from the usage method described below, the compression container 2 is configured to have higher rigidity than the compression container 2 in order to prevent the compression container 2 from being inadvertently compressed. That is, it is made of a material harder than the compression container 2, or is formed thicker than the compression container 2.

As a material for forming the cover member 4, it is preferable to use a synthetic resin which can be easily molded. As such a synthetic resin, those exemplified as the synthetic resin material for forming the reaction vessel 3 described above are used. Can be used as well.

The cover member 4 and the compression container 2 are also preferably made of a transparent material, like the reaction container 3, so that the stool sample dissolution state inside can be visually observed from the outside. Will be easier.

In the above structure example, the compression container 2 and the reaction container 3 and the compression container 2 and the cover member 4 are detachable by screws, but other methods for forming such screws are also available. Alternatively, the inner and outer diameters of these members may be adjusted to be liquid-tightly and detachably fixed to each other.

Next, an example of a method of using the fecal occult blood test apparatus 1 will be described. First, the state shown in FIG. 1 is reversed upside down, and the cover member 4 is removed from the compression container 2 in this state.

Next, the stool solution 6 is prevented from spilling, the reaction container 3 and the stool collection instrument body 5 are removed from the compression container 2, the stool collection part 5a is pierced into the stool, and stool is collected. Then, after collecting stool, the stool collection instrument body 5 is inserted into the compression container 2 and the reaction container 3 is attached to the compression container 2 again.

Next, the structure in which the reaction container 3 and the stool collection instrument body 5 are attached to the compression container 2 is shaken to dissolve stool in the stool solution 6 to obtain a stool sample solution. After that, the anti-human hemoglobin antibody sensitizing reagent 9 in the reaction container 3 is kept in a downward direction, and as shown in FIG.
The side wall of the compression container 2 is pressed. By this pressing, the stool sample solution is introduced into the inflow port 5b, and a few drops are dropped from the dropping port 5d through the internal flow path 5c. In this case, it is preferable to control the force pressing the side wall of the compression container 2 so that the fecal sample solution may drop from the dropping port 5d by about a few drops.

Then, the reaction vessel 3 is slowly moved by hand to 2-3.
The mixture is shaken for a minute, and the dropped stool sample solution and the anti-human hemoglobin antibody sensitizing reagent 9 are mixed. After the mixing is completed, the degree of aggregation is visually determined. In this determination, when the reaction container 3 is made of a transparent material, the degree of aggregation can be visually observed from the outside. Further, when the reaction container 3 is not transparent, or when it is difficult to determine aggregation from the outside, the stool collection instrument body 5 may be removed from the reaction container 3.

When aggregation is observed, it is positive, and when aggregation is not observed (milky state), it is negative.

[0048]

In the fecal occult blood test apparatus of the present invention, stool is collected by the stool collection part of the stool collection device body fixedly provided in the reaction container, and the stool collection device body is inserted into the compression container to form the reaction container. The stool sample can be dissolved in the stool dissolution solution by shaking with the compression container fixed, and the stool sample solution can be sensitized to the anti-human hemoglobin antibody from the dropping port simply by pressing the compression container by hand in that state. It can be dropped on the preparation reagent. Then, in the reaction vessel, the anti-human hemoglobin antibody sensitizing reagent and the stool sample solution are mixed, and the presence or absence of fecal occult blood is observed by observing the agglutination image generated by the antigen-antibody reaction between the occult blood and anti-human hemoglobin antibody. Can be determined.

That is, in the fecal occult blood test apparatus of the present invention,
Based on the immunological reaction, a series of operations from collecting a stool sample to detecting fecal occult blood can be easily performed.

[0050]

According to the present invention, therefore, fecal occult blood can be easily tested based on the immunological fecal occult blood reaction method without requiring much skill. Moreover, since the immunological fecal occult blood reaction is used, the subject does not need to have a strict dietary restriction before the test.

After the test is completed, if the above-mentioned compression container, reaction container and cover member are integrated, it is possible to prevent odor and leakage of the stool sample solution. be able to.

Further, as described above, in the fecal occult blood test apparatus of the present invention, the compression container and the reaction container are integrated to prevent the smell of the stool sample and the leakage of the stool sample solution. In addition, the fecal occult blood test apparatus in which a large number of samples are collected can be transported hygienically and easily. Furthermore, after the inspection, they can be easily and hygienically disposed of in an integrated state.

Therefore, it can be suitably used for OTC diagnosis which will become more and more popular in the future. When the cover member is provided as in the second aspect of the present invention, the compression container is not accidentally compressed during the above-described transportation or placement, so that the transportation is more hygienic. Or processing can be performed. Furthermore, since the compression container is not accidentally compressed before the test, the fecal occult blood test apparatus of the present invention can be reliably provided for the test.

[0054]

EXAMPLES Examples of the present invention will be described below. Example 1 (1) Preparation of antibody-sensitized carrier An anti-human Hb monoclonal antibody (mouse MU) was used as an antibody.
-110: 10 ml of a phosphate buffer solution (pH 7.2: 200 μl / ml) of (Japan Biotest Institute) was prepared. Furthermore, it was added to 10 ml of polystyrene blue latex (average particle size 0.12 μm: solid content 5%), and the temperature was 37 ° C.
And stirred for 60 minutes. The obtained dispersion was heated to 18.0 at 4 ° C.
Centrifuged at 00 rpm for 50 minutes. After removing the supernatant, a phosphate buffer solution (pH 7.2) and a phosphate buffer solution (pH 7.2) of 1% by weight bovine serum albumin (manufactured by Sigma: hereinafter referred to as "BSA") were added, The latex concentration was adjusted to 1%.

(2) Immobilization of antibody-sensitized carrier 50 μl of the antibody-sensitized latex obtained in (1) above was
It was dropped on the bottom of the reaction vessel 3 in FIG. 1 and dried.

(3) Preparation of Fecal Occult Blood Test Device The same fecal occult blood test device as in FIG. 1 was used. In this case, the compression container 2 was made of polyethylene, and the reaction container 3 was also made of polyethylene. As the stool collection device body 5, one made of polyethylene and having the plurality of projections 7 shown in FIG. 1 was used. Furthermore, as the filter 8, a filter for liquid chromatography (manufactured by Sekisui Chemical Co., Ltd.) having an average pore diameter of 2 μm was used. As the stool solution 6 stored in the compression container 2, 2.0 ml of a phosphate buffer solution having a pH of 7.2 was used.
As the cover member 4, a cover member made of polyethylene having a thickness larger than that of the compression container 2 was used.

Test Example 1 In this example, a sensitivity test was carried out using a human Hb standard solution.
Human Hb (manufactured by Sigma) was added to a phosphate buffer (pH 7.
2), and the solution was added to the stool solution 6 prepared in Example 1 so as to have a concentration of 0 to 10 μg / ml.
After that, the stool collection device body 5 is inserted into the compression container 2,
After attaching the reaction container 3 and shaking it gently, the reaction container 3 side is arranged in a downward direction, and the compression container 2 is pressed with a finger,
The above-mentioned buffer solution containing human Hb was dropped onto the human hemoglobin antibody sensitizing reagent 9 through the dropping port 5d. After standing for 5 minutes, the presence or absence of aggregation was visually determined. From the results of Test Example 1, it was confirmed that the measurement sensitivity of human Hb in the fecal occult blood test apparatus 1 of the present invention was 0.25 μg / ml.

Test Example 2 In this example, a certain amount of human Hb preparation was added to a human stool sample, and the presence or absence of fecal occult blood was measured using the stool sample to which the human Hb preparation was added. That is, in the same manner as in Test Example 1,
The above human Hb preparation was added to the stool lysate 6, and a certain amount of stool sample was collected from the stool of a healthy person using the stool collection device body 5, and the stool collection device body 5 was allowed to enter the compression container 2. The reaction container 3 was attached to the compression container 2. Then, the same operation as in Test Example 1 was performed to make a judgment. As a result, no stool sample interference was observed.

[Brief description of drawings]

FIG. 1 is a longitudinal sectional view showing a structural example of a fecal occult blood test apparatus of the present invention.

FIG. 2 is a front view showing the appearance of the fecal occult blood test apparatus of the present invention.

FIG. 3 is a front view showing a fecal sampling device body used in the fecal occult blood test apparatus shown in FIG. 1.

FIG. 4 is a vertical cross-sectional view for explaining a step of dropping a fecal sample solution when using the fecal occult blood test apparatus.

5 (a) and 5 (b) are partial cutaway front views each showing a modified example of the shape of the stool collection part.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 ... Fecal occult blood test apparatus 2 ... Compressed container 3 ... Reaction container 4 ... Cover member 5 ... Stool collection device body 6 ... Stool dissolution solution 7 ... Protrusion 8 ... Filter 9 ... Anti-human hemoglobin antibody sensitizing reagent

Continuation of front page (51) Int.Cl. ⁶ Identification number Office reference number FI technical display location G01N 33/72 A 35/10

Claims (2)

[Claims] 1. A compression container having an opening and containing a stool solution for dissolving a stool sample to prepare a stool sample solution, and comprising a compressible flexible material, A reaction container detachably attached to the compression container so as to close the opening of the compression container, and an anti-human hemoglobin antibody sensitizing reagent is fixed therein, and is integrally configured in the reaction container. A stool sample body having a stool sample solution preparation part extending into the compression container and a stool sample solution dropping part extending into the reaction container in a state where the reaction container is attached to the compression container, The solution preparation part is provided on the outer surface,
And a stool collection part for collecting stool, an inflow port into which the stool sample solution flows in, the stool sample solution dropping part is formed with a dropping port for dropping the stool sample solution, The main body of the stool collection instrument is provided with an internal flow path connecting the inflow port and the dripping port, and a filter for removing solids in the stool sample solution is disposed in the internal flow path. Fecal occult blood test equipment. 2. The fecal occult blood test apparatus according to claim 1, further comprising a cover member which is detachably attached to the compression container so as to cover the compression container and which is made of a material harder than the compression container. .