JPH0720010A - Liquid dispensing device - Google Patents
Liquid dispensing deviceInfo
- Publication number
- JPH0720010A JPH0720010A JP18864293A JP18864293A JPH0720010A JP H0720010 A JPH0720010 A JP H0720010A JP 18864293 A JP18864293 A JP 18864293A JP 18864293 A JP18864293 A JP 18864293A JP H0720010 A JPH0720010 A JP H0720010A
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- JP
- Japan
- Prior art keywords
- liquid
- sections
- dispensing
- liquid storage
- liquids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- Sampling And Sample Adjustment (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
Description
【０００１】[0001]
【産業上の利用分野】この発明は、大学、病院等の理化
学検査、臨床検査等に於いて、試薬を分注、混合するの
に使用する液体分注装置に係り、詳記すれば、複数の液
体分注部を独立して制御し得るようにした液体分注装置
に関するものである。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a liquid dispensing device used for dispensing and mixing reagents in physics and chemistry examinations, clinical examinations, etc. in universities, hospitals, etc. The present invention relates to a liquid dispensing device capable of independently controlling the liquid dispensing part.
【０００２】[0002]
【従来の技術】液体の分注に於いて、定量ポンプを使用
し、エア−を介して一定量の液体を吸引し、これを分注
する液体分注装置は、特に接触不安定な液体、高価な液
体等の分注に大学、病院等で広く使用されている。この
ような分注装置としては、従来図８に示すように、操作
の簡便化と処理速度の向上を目的として、４連、８連、
１２連等の定量ポンプ（図示せず）にピペット１をそれ
ぞれ接続し、全てのピペット１から試薬槽２の液体を同
時に吸入し、これをプレート３のウエル４内に同時に分
注する装置が知られていた。2. Description of the Related Art In liquid dispensing, a liquid dispensing device for sucking a fixed amount of liquid through air using a metering pump and dispensing the liquid is particularly Widely used in universities and hospitals for dispensing expensive liquids. As such a dispensing device, as shown in FIG. 8, conventionally, for the purpose of simplifying the operation and improving the processing speed, four stations, eight stations,
There is known a device in which the pipettes 1 are connected to 12 continuous metering pumps (not shown), and the liquids in the reagent tanks 2 are simultaneously sucked from all the pipettes 1 and dispensed into the wells 4 of the plate 3 at the same time. It was being done.
【０００３】しかしながら、上記分注装置は、複数の定
量ポンプは備えているものの、その制御部及び駆動部は
１個であったので、定量ポンプ毎に分注の可否を決定す
ることができないという問題があった。そのため、必然
的に試薬は全てのピペット１から試薬がウエル４内に分
注されるが、試薬が分注されたウエル４（ピペット１の
数だけある）の全てにピペット１からの試薬と反応させ
るべき検体が充填されているとは限らないので、充填さ
れていない場合は、ウエル４内に分注された試薬は全く
の無駄となる。この種分注に使用する試薬は一般に高価
なものが多いので、そのまま廃棄するのは極めて不経済
であるが、さりとて検体の充填されていないウエル４の
みから試薬を回収しようとすると、迅速な処理操作の妨
げになるという新たな問題が生じる。However, although the above-mentioned dispensing device is equipped with a plurality of metering pumps, since it has only one control unit and one driving unit, it is impossible to determine whether or not dispensing is possible for each metering pump. There was a problem. Therefore, the reagent is inevitably dispensed from all the pipettes 1 into the wells 4, but all the wells 4 (where there are as many pipettes 1) in which the reagent is dispensed react with the reagents from the pipettes 1. Since the specimen to be treated is not always filled, the reagent dispensed in the well 4 is completely wasted when it is not filled. Since many reagents used for this kind of dispensing are generally expensive, it is extremely uneconomical to discard them as they are. However, if it is attempted to recover the reagents only from the wells 4 in which the sample is not filled, rapid processing is required. A new problem arises that hinders operation.
【０００４】また、上記分注装置を使用して測定を行っ
た場合には、一連の測定を同一マイクロプレ−ト上で効
率よく実施できないという問題が生じる場合が多い。即
ち、検体中の特定の抗原や抗体の力価の検定は、種々の
希釈倍率の検体を順次ウエル４内に充填して抗原抗体反
応が検出されなくなる希釈倍率を求めることにより行う
が、初めに準備した希釈倍率まででは陽性の結果しか得
られず、更に希釈した検体を用いて追加実験を行う必要
が生じる場合が多い。この場合、目的の倍率に希釈した
検体を、既に実施済みの検体希釈列のウエル４の隣のウエ
ル４から順次充填できれば、一連の結果が一目で判るの
で好ましいことは明らかであるが、上記分注装置を使用
した場合は、該ウエル４には既に試薬が分注されている
ので、改めて希釈検体を充填することはできないという
問題が生じるのである。検体と試薬の分注の順序を守ら
ないと測定が不可能であるからである。In addition, when the above-mentioned dispensing device is used for measurement, there is often a problem that a series of measurement cannot be efficiently carried out on the same microplate. That is, the assay of the titer of a specific antigen or antibody in a sample is carried out by sequentially filling the wells 4 with various dilution ratios of the sample and determining the dilution ratio at which the antigen-antibody reaction is not detected. Only a positive result can be obtained up to the prepared dilution ratio, and it is often necessary to perform an additional experiment using a diluted sample. In this case, it is clear that a series of results can be seen at a glance if the sample diluted to the target magnification can be sequentially filled from the well 4 next to the well 4 of the already-executed sample dilution column. When the injection device is used, the reagent has already been dispensed into the well 4, so that there is a problem that the diluted specimen cannot be filled again. This is because measurement cannot be performed unless the order of dispensing the sample and the reagent is observed.
【０００５】上記多連定量ポンプのポンプ毎に分注の可
否を決定するには、ポンプ毎にポンプの制御部と駆動部
を設ければ良いわけであるが、このことは必然的に装置
を長大化させ、装置も複雑高価となるので実用化されて
いない。そのため、従来、ポンプ毎に分注の可否を決定
する分注装置は、市販されていないし、知られていな
い。ピペットが１個のシングルピペットであれば、上記
したような同時分注に伴う問題は生じないが、これでは
高速処理の要請を満たすことはできない。In order to determine whether or not dispensing is possible for each of the multiple metering pumps described above, it is sufficient to provide a pump control unit and a drive unit for each pump, but this inevitably requires a device. It has not been put to practical use because it is lengthened and the device becomes complicated and expensive. Therefore, conventionally, a dispensing device that determines whether or not dispensing is possible for each pump has not been commercially available or known. If the pipette is a single pipette, the above problems associated with simultaneous dispensing do not occur, but this cannot satisfy the demand for high-speed processing.
【０００６】[0006]
【発明が解決しようとする課題】この発明は、このよう
な点に着目してなされたものであり、簡単な方法によ
り、多連定量ポンプのポンプ毎に分注の可否を決定する
ことができ、しかも高速処理することができる分注装置
を提供することを目的とする。SUMMARY OF THE INVENTION The present invention has been made paying attention to such a point, and it is possible to determine whether or not dispensing can be performed for each pump of a multiple metering pump by a simple method. Moreover, it is an object of the present invention to provide a dispensing device capable of high-speed processing.
【０００７】[0007]
【課題を解決するための手段】上記目的に沿う本発明の
構成は、定量ポンプのガス圧によって、該定量ポンプに
接続した貯液部の液体の吸排出を行う液体分注装置に於
いて、前記定量ポンプと前記貯液部とで１組を構成する
液体分注部を複数組設け、前記定量ポンプと前記貯液部
との間に、自動バルブを配設し、該バルブによりガスを
前記貯液部に導入するか、或は前記貯液部外に排出する
かの制御と、ガスを前記貯液部から吸入するか、或は前
記貯液部外から吸入するかを制御することによって、前
記液体分注部の液体の分注を独立して制御し得るように
したことを特徴とする。The structure of the present invention which meets the above-mentioned object is a liquid dispensing apparatus for sucking and discharging the liquid in a liquid storage part connected to the metering pump by the gas pressure of the metering pump, A plurality of sets of liquid dispensing sections, each of which comprises one set of the constant quantity pump and the liquid storage section, are provided, and an automatic valve is provided between the constant quantity pump and the liquid storage section, and the gas is supplied by the valve. By controlling whether the gas is introduced into the liquid storage part or discharged to the outside of the liquid storage part, and whether the gas is inhaled from the liquid storage part or from the outside of the liquid storage part It is characterized in that the liquid dispensing of the liquid dispensing unit can be controlled independently.
【０００８】[0008]
【実施例】次に、本発明の実施例を図面に基づいて説明
する。図１は、８連液体分注装置の概略図を示すもので
あり、小型パルスモータ１２により駆動される定量ポン
プ１３と貯液部（ピペット）１６との間に、エア−の前
記貯液部１６への導入若しくは貯液部１６からの吸入
と、エア−の前記貯液部１６外への排出若しくは貯液部
外からの吸入を制御する三方電磁弁１４とを配設し、前
記モータ１２と三方電磁弁１４とを制御器１１により制
御し得るように構成した例を示す。Embodiments of the present invention will now be described with reference to the drawings. FIG. 1 shows a schematic view of an eight-line liquid dispensing apparatus, in which a liquid-storing part of air is provided between a metering pump 13 driven by a small pulse motor 12 and a liquid-storing part (pipette) 16. A three-way solenoid valve 14 for controlling the introduction into or suction from the liquid storage portion 16 and the discharge of air to the outside of the liquid storage portion 16 or the suction from the outside of the liquid storage portion 16; An example in which the three-way solenoid valve 14 and the three-way solenoid valve 14 can be controlled by the controller 11 will be shown.
【０００９】定量ポンプ１３は、モ−タ１２によりギヤ
−１５を回動させ、ギヤ−１５と歯合するラックギヤ−
２０を上下動させて、シリンダ−２１内のピストン棒１
７を上下動させることによりエア−の吸排出を行い、エ
アーの吸排出に連動して、貯液部１６からの液体の吸排
出若しくは三方電磁弁１４からのエア−の吸排出を行う
ことができるようになっている。本発明に於いては、定
量ポンプ１３は、ガスの吸排出によって、貯液部１６内
の液体の吸排出を制御し得るものであれば良く、特にそ
の種類は限定されない。The metering pump 13 is a rack gear which meshes with the gear 15 by rotating the gear 15 with the motor 12.
20 is moved up and down to move the piston rod 1 in the cylinder 21.
By moving 7 up and down, air can be sucked and discharged, and in conjunction with suction and discharge of air, suction and discharge of liquid from the liquid storage portion 16 or suction and discharge of air from the three-way solenoid valve 14 can be performed. You can do it. In the present invention, the metering pump 13 is not particularly limited as long as it can control the suction and discharge of the liquid in the liquid storage section 16 by the suction and discharge of gas.
【００１０】上記実施例に於いては、８連の分注装置を
示したが、複数であるなら特にその数は限定されない。
しかしながら、処理速度の向上には、一般的なマイクロ
プレ−トに好適な４連、８連、１２連等とするのが好ま
しい。上記実施例に於いては、定量ポンプ１３と貯液部
１６との間に、三方電磁弁を１個設けているが、これは
必ずしもこのようでなくともよく、二方電磁弁を２個設
けても三方電磁弁と同様の作用をするので差し支えな
い。三方電磁弁及び二方電磁弁のような自動バルブとし
ては、電磁弁に限らず、例えばエアー駆動式自動バルブ
のような他の自動バルブでもよい。In the above-mentioned embodiment, eight dispensing devices are shown, but the number is not particularly limited as long as it is plural.
However, in order to improve the processing speed, it is preferable to use 4, 8, 12, etc., which are suitable for general microplates. In the above embodiment, one three-way solenoid valve is provided between the metering pump 13 and the liquid storage unit 16, but this is not necessarily the case, and two two-way solenoid valves are provided. However, there is no problem since it works the same as a three-way solenoid valve. The automatic valve such as the three-way solenoid valve and the two-way solenoid valve is not limited to the solenoid valve and may be another automatic valve such as an air-driven automatic valve.
【００１１】[0011]
【作用】次に、上記のように構成された本発明の作用を
図２〜図７の２連液体分注装置に基づいて説明する。
尚、図中黒く塗り潰した二方電磁弁は弁を閉じた状態を
示し、白地の二方電磁弁は弁が開いた状態を示す。図２
に示すように、定量ポンプ１３，１３′からエア−を全
量排出し、貯液部１６，１６′内には、液体が存在しな
い状態とする。この際、電磁弁１８，１８′は閉じてお
り、電磁弁１９，１９′は開いている。ついで、貯液部
１６，１６′の先端を液体中に浸し、モ−タ１２により
定量ポンプ１３，１３′のピストン棒１７，１７′を上
昇させて液体を吸入すると、図３に示すように、液体は
貯液部１６，１６′中に充填される。Next, the operation of the present invention constructed as described above will be explained based on the double liquid dispensing apparatus of FIGS.
The black two-way solenoid valve in the figure shows the valve closed, and the white two-way solenoid valve shows the valve open. Figure 2
As shown in (3), all the air is discharged from the metering pumps 13 and 13 'so that no liquid exists in the liquid storage portions 16 and 16'. At this time, the solenoid valves 18, 18 'are closed and the solenoid valves 19, 19' are open. Then, the tips of the liquid storage parts 16 and 16 'are immersed in the liquid, and the piston rods 17 and 17' of the metering pumps 13 and 13 'are raised by the motor 12 to suck the liquid, as shown in FIG. The liquid is filled in the liquid storage parts 16 and 16 '.
【００１２】貯液部１６，１６′中の液体を同時に分注
する場合は、図４に示すように、電磁弁１８，１８′，
１９，１９′はこのままの状態で、定量ポンプ１３，１
３′のピストン棒１７，１７′を下降させて液体を分注
すればよい。貯液部１６，１６′中の一方の液体を分注
する場合は、図５に示すように、分注する貯液部１６と
の間に配設されている電磁弁１８，１９はこのままの状
態で、分注しない貯液部１６′との間に配設した電磁弁
１８′を開とし、１９′を閉とし、定量ポンプ１３，１
３′のピストン棒１７，１７′を下降させればよい。そ
の結果、貯液部１６中にはエア−が導入されるので、貯
液部１６中の液体は排出されるが、貯液部１６′中には
エア−が導入されずに、エア−は電磁弁１８′から排出
されるので、貯液部１６′中の液体は排出されない。When the liquids in the liquid storage parts 16, 16 'are simultaneously dispensed, as shown in FIG. 4, the solenoid valves 18, 18',
19 and 19 'are in this state as they are, and the metering pumps 13 and 1 are
The liquid may be dispensed by lowering the 3'piston rods 17, 17 '. When one of the liquids in the liquid storage parts 16, 16 'is dispensed, as shown in FIG. 5, the solenoid valves 18, 19 arranged between the liquid storage part 16 to be dispensed are left as they are. In this state, the solenoid valve 18 'disposed between the non-dispensed liquid storage portion 16' and the solenoid valve 18 'are opened, and 19' are closed, so that the metering pumps 13 and 1 are closed.
The 3'piston rod 17, 17 'may be lowered. As a result, since the air is introduced into the liquid storage portion 16, the liquid in the liquid storage portion 16 is discharged, but the air is not introduced into the liquid storage portion 16 'and the air- Since it is discharged from the solenoid valve 18 ', the liquid in the liquid storage portion 16' is not discharged.
【００１３】図６は、液体を一部分注した後の初期化動
作を示すものであり、貯液部１６，１６′への流路を開
閉する電磁弁１９，１９′を閉とし、大気中への流路を
開閉する電磁弁１８，１８′を開とし、定量ポンプ１
３，１３′のピストン棒１７，１７′を上昇させる。こ
の動作で分注操作に使用した量のエア−を電磁弁１８，
１８′を通じて外部から吸引することができる。図７
は、貯液部１６，１６′中の液体を全量排出させる初期
化動作を示すものであり、貯液部１６，１６′への流路
を開閉する電磁弁１９，１９′を開とし、大気中への流
路を開閉する電磁弁１８，１８′を閉とし、定量ポンプ
１３，１３′のピストン棒１７，１７′を下降させて、
エア−と液体の全量を排出し、図２と同じ状態とし、次
の吸引動作に備える。上記作用に於いて、モ−タ１２及
び電磁弁１８，１８′，１９，１９′の制御は、制御器
１１による公知の方法によって制御されるようになって
いる。FIG. 6 shows an initialization operation after a part of the liquid has been poured. The electromagnetic valves 19 and 19 'for opening and closing the flow paths to the liquid storage portions 16 and 16' are closed to open the atmosphere. Open the solenoid valves 18 and 18 'that open and close the flow path of the metering pump 1
The piston rods 17, 17 'of 3, 13' are raised. In this operation, the amount of air used for the dispensing operation is changed to the solenoid valve 18,
It can be sucked from the outside through 18 '. Figure 7
Shows an initialization operation for discharging all the liquid in the liquid storage parts 16, 16 ', and opens the solenoid valves 19, 19' for opening and closing the flow paths to the liquid storage parts 16, 16 'to open the atmosphere. Solenoid valves 18 and 18 'that open and close the flow path to the inside are closed, and piston rods 17 and 17' of the metering pumps 13 and 13 'are lowered,
All the air and liquid are discharged, and the same state as in FIG. 2 is obtained to prepare for the next suction operation. In the above operation, the motor 12 and the solenoid valves 18, 18 ', 19, 19' are controlled by the controller 11 by a known method.
【００１４】[0014]
【効果】以上述べたごとく、本発明によれば、極めて簡
単な構成によって、液体を吸排出する複数の貯液部を独
立して制御し、分注することができるので、マイクロプ
レートのウエル毎に分注することができ、使用する試薬
の無駄が省けて経済的であるというシングルピペットの
利点と、高速処理が可能であるという多連ピペットの利
点とを併有するものであり、この種従来の分注装置には
全く見られなかった顕著な効果を奏する。As described above, according to the present invention, it is possible to independently control and dispense a plurality of liquid storage parts for sucking and discharging a liquid with an extremely simple structure. It has both the advantage of a single pipette that can be dispensed into a container, is economical because waste of used reagents is saved, and the advantage of a multiple pipette that enables high-speed processing. It has a remarkable effect that was not seen at all in the dispensing device.
【００１５】[0015]
【図１】本発明の実施例を示す概略断面図である。FIG. 1 is a schematic sectional view showing an embodiment of the present invention.
【図２】本発明の分注装置の初期状態を示す概略断面図
である。FIG. 2 is a schematic sectional view showing an initial state of the dispensing device of the present invention.
【図３】本発明の分注装置に液体を充填した状態を示す
概略断面図である。FIG. 3 is a schematic cross-sectional view showing a state in which a liquid is filled in the dispensing device of the present invention.
【図４】本発明の分注装置に充填された液体を同時分注
した状態を示す概略断面図である。FIG. 4 is a schematic cross-sectional view showing a state in which the liquid filled in the dispensing apparatus of the present invention is simultaneously dispensed.
【図５】本発明の分注装置の一方の貯液部から液体を分
注した状態を示す概略断面図である。FIG. 5 is a schematic cross-sectional view showing a state in which a liquid is dispensed from one liquid storage portion of the dispensing device of the present invention.
【図６】本発明の分注装置に於いて、液体を充填した状
態から初期化する状態を示す概略断面図である。FIG. 6 is a schematic cross-sectional view showing a state of initializing from a state of being filled with a liquid in the dispensing device of the present invention.
【図７】本発明の分注装置に於いて、液体を全て排出し
て初期化する状態を示す概略断面図である。FIG. 7 is a schematic cross-sectional view showing a state in which all liquid is discharged and initialized in the dispensing device of the present invention.
【図８】従来の分注装置を示す斜視図である。FIG. 8 is a perspective view showing a conventional dispensing device.
１１ 制御器 １２ モータ １３，１３′ 定量ポンプ １６，１６′ 貯液部（ピペット） １８，１８′，１９，１９′ 電磁弁 11 Controller 12 Motor 13, 13 'Metering Pump 16, 16' Liquid Storage (Pipette) 18, 18 ', 19, 19' Solenoid Valve
Claims (1)
プに接続した貯液部の液体の吸排出を行う液体分注装置
に於いて、前記定量ポンプと前記貯液部とで１組を構成
する液体分注部を複数組設け、前記定量ポンプと前記貯
液部との間に、自動バルブを配設し、該バルブによりガ
スを前記貯液部に導入するか、或は前記貯液部外に排出
するかの制御と、ガスを前記貯液部から吸入するか、或
は前記貯液部外から吸入するかを制御することによっ
て、前記液体分注部の液体の分注を独立して制御し得る
ようにしたことを特徴とする液体分注装置。1. A liquid dispensing apparatus for sucking and discharging a liquid in a liquid storage unit connected to the liquid metering pump by the gas pressure of the liquid metering pump, wherein the liquid metering pump and the liquid storing unit form one set. A plurality of sets of liquid dispensing parts are provided, and an automatic valve is provided between the metering pump and the liquid storage part, and gas is introduced into the liquid storage part by the valve, or the liquid storage part. By controlling whether to discharge the gas to the outside and whether to inhale the gas from the liquid storing section or from the outside of the liquid storing section, the liquid dispensing of the liquid dispensing section can be performed independently. A liquid dispensing device characterized in that the liquid dispensing device can be controlled by means of.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP18864293A JP3339650B2 (en) | 1993-07-02 | 1993-07-02 | Liquid dispensing device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP18864293A JP3339650B2 (en) | 1993-07-02 | 1993-07-02 | Liquid dispensing device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH0720010A true JPH0720010A (en) | 1995-01-24 |
| JP3339650B2 JP3339650B2 (en) | 2002-10-28 |
Family
ID=16227291
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP18864293A Expired - Fee Related JP3339650B2 (en) | 1993-07-02 | 1993-07-02 | Liquid dispensing device |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP3339650B2 (en) |
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| JP2004512520A (en) * | 2000-10-24 | 2004-04-22 | フラウンホーファ−ゲゼルシャフト ツァー フォルデルング デア アンゲバンデン フォルシュンク エー． ファオ． | Pipette system and pipette array |
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1993
- 1993-07-02 JP JP18864293A patent/JP3339650B2/en not_active Expired - Fee Related
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| Publication number | Publication date |
|---|---|
| JP3339650B2 (en) | 2002-10-28 |
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