JPH07187985A - Skin-beautifying agent consisting essentially of phytic acid or its salts - Google Patents

Abstract

PURPOSE:To obtain phytic acid or its salts having improving effect on keratin of skin and preventing effect on aging, useful as a skin beautifying agent. CONSTITUTION:This agent for improving keratin of skin and preventing aging comprises phytic acid or its salts. The agent is expected to prevent and treat pimple and to have suppressing effects on viruses and bacteria causing a freckle and a wart of skin.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a skin beautifying agent containing phytic acid and its salt as a main component and having effects of improving skin keratin and preventing aging.

[0002]

2. Description of the Related Art Phytic acid has long been known as a chelating agent and has been used as an additive for foods and industrial products. Recently, however, the present applicants have shown that urine odor, deodorizing effect, and metabolic diseases caused by oral administration. The therapeutic effects of the drug have been discovered and have attracted attention (Japanese Patent Publication No. 4-76971, Japanese Patent Publication No. 5-3).
9929, U.S. Pat. No. 4,929,438). In addition, white cosmetics utilizing the tyrosinase inhibitory action of kojic acid and the like are known (Japanese Patent Publication No. Sho 56-18589, JP-A No. 63-20).
8510, etc.). For skin beautifying agents, suppression of skin secretions, suppression of offensive odors due to secretions, skin protection effects, and psychological research from the perspective of fragrances have been conducted. It is used as a deodorant agent and a cosmetic agent, but few of them can be expected to have effective effects other than the psychological effect. In addition, acne and mollusks and warts that parasitize the skin are known to be caused by metabolic abnormalities, parasitism of pathogenic microorganisms, and tissue abnormalities caused by contact with light rays and toxic substances. These are surgical removal of abnormal tissues (corrosion caused by salicylic acid drugs, cell freezing by liquid nitrogen, etc.), removal of causative substances, and skin cleansing, and effective prevention can be expected. The treatment method has not been established yet.

[0003]

A general preparation that is expected to have a beautiful skin effect is an antiperspirant such as an aluminum compound that causes skin proteins to converge, blocks sweat glands, and prevents sweat from being exposed on the surface of the skin. Although bactericides, antioxidants, and fragrances are used as ingredients, these are highly toxic to the skin and the amount used is limited to a low concentration, and it is difficult to obtain a sufficiently satisfactory effect. Further, there is no report of a technique for cleaning the skin with a soap and the like for a short time, but the cleaning effect lasts for a long time.

[0004]

Means and Actions for Solving the Problems The present invention is directed to improving skin keratin of phytic acid or a salt thereof, enhancing antiaging effect by devising a formulation, and using this substance as a cosmetic agent, deodorant agent, washing soap, etc. By adding phytic acid or its salt to the active substance, it has a long-lasting cleansing effect (suppressive effect on skin secretions), the prevention and treatment of acne, the treatment and prevention of warts and mollusks caused by skin parasites. The present invention is based on the discovery and provides a skin beautifying agent which is not irritating to the skin and has a remarkable body odor preventing effect. Further, as an additional effect of the skin beautifying agent, rice germ oil is added to enhance the effect, thereby providing a deodorant agent having a skin beautifying effect. The problems of the present invention are as follows: (1) A skin beautifying agent comprising phytic acid and a salt thereof which has effects of improving skin keratin and preventing aging. (2) A skin-care agent having a bath form, a cosmetic composition, or a cream form, which contains a phytic acid activating composition in which one or more metal ions are selected and phytic acid and a salt are combined. (3) It is composed of a skin beautifying agent containing rice germ oil as desired.

That is, as a result of various studies, the present inventors have found that the topical drug for external use consisting of phytic acid and salts thereof according to the present invention has remarkable skin keratin improvement and skin beautifying effect which is considered to be due to aging prevention. It was discovered that a phytic acid activating composition obtained by selecting one or more kinds of metal ions to form a salt with phytic acid has an outstanding skin-beautifying effect without skin irritation.

[0006] Acne is a biological secretion such as sweat, in which fatty acids and the like are decomposed by bacteria on the skin surface and further oxidatively decomposed to generate odorous substances such as lower fatty acids and destroy peripheral cells. This is manifested as inflammation and a strange odor. In addition, in mollusks and warts, viruses and bacteria on the skin surface are proliferated by biological secretions such as sweat, and normal cells are mutated by the secretions, sun rays, and toxic substances. On the other hand, a phytic acid activating composition consisting of phytate acts as an enzyme inhibitor of viruses, urease, lipase, protease, etc. of bacteria, and also acts as an antioxidant to develop a skin-beautifying effect. Conceivable.

The action as an enzyme inhibitor of urease, lipase, protease, etc. is presumed to be due to the fact that the phytic acid-activating composition acts as an effective chelating agent by incorporating trace metals of bacterial enzymes and deactivating the enzymes. To be done. Further, the action as an antioxidant is presumed to be due to the fact that the phytic acid activating composition serves as an effective chelating agent and sequesters a trace amount of metal serving as an oxidation catalyst.

The phytate formed by selecting one or more kinds of metal ions to form a salt with phytic acid has a mild effect on the living body and has no skin irritation. This is because the strong chelating effect of phytic acid itself is replaced with a metal (Na, K, Ca, Mg, etc.) capable of substituting the trace metals required for bacterial enzymes in advance to form phytate, thereby improving the effect on the living body. It is presumed that the mildness and the action as the enzyme inhibitor are compatible with each other. The fact that there is no skin irritation is as a deodorant agent,
This is very important when considering its long-term use and wide-area use.

[0009] Further, although the skin-improving effect of rice germ oil is very effective, in reality, rice germ oil itself has poor oxidative stability, and it is difficult to achieve a sufficient effect. On the other hand, the phytic acid-activating composition composed of phytate exhibits an action of enhancing the skin beautiful effect of rice germ oil.
It is presumed that this is due to the stability or activity at the application site as well as the increase in the stability of the product during storage.

The amount of the phytic acid activating composition comprising phytate is preferably 50% (W / V) or less as phytic acid. The metals that form salts with phytic acid are Na, K, Ca,
Mg or the like is preferable, and the addition ratio of phytic acid and metal is such that the monovalent metal is in a molar ratio of phytic acid: metal = 1: 6 to 1:12,
The divalent metal has a molar ratio of phytic acid: metal = 1: 3 to 1:
A range of 6 is preferred. Examples and test examples are given below,
The present invention will be described in more detail.

[0011]

【Example】

Formulation Example 1 (shampoo) Phytic acid and magnesium hydroxide were weighed at a molar ratio of 1: 6, and an appropriate amount of water was added to obtain a phytic acid concentration of 5
% Phytic acid activating composition A was obtained as an aqueous solution.
The shampoo was weighed according to the following formulation and used as a shampoo by a conventional method. Phytic acid activated composition A 2 ml Sodium alkyl ether sulfate 16 g Lauric acid diethanolamide 4 g Propylene glycol 2 g Water Appropriate amount total 100 ml

Formulation Example 2 (shampoo) Phytic acid and sodium hydroxide were weighed at a molar ratio of 1: 6, and an appropriate amount of water was added to obtain a phytic acid concentration of 20.
% Phytic acid activating composition B was obtained as an aqueous solution.
The shampoo was weighed according to the following formulation and used as a shampoo by a conventional method. Phytic acid activated composition B 25 ml Amisoft CT-12 15 g (cocoylyl fatty acid cesyl-L-glutamic acid monoethanolamine 30%) Sodium lauryl ether sulfate 16 g Coconut oil fatty acid diethanolamide 4.5 g PCA soda (50%) 1 g Water proper amount total 100 ml

Formulation Example 3 (bath preparation) Phytic acid and potassium hydroxide were weighed in a molar ratio of 1:12, and an appropriate amount of water was added to obtain a phytic acid concentration of 25%.
A phytic acid-activating composition C was obtained as an aqueous solution of The following formulation was weighed and used as a bath agent by a conventional method. Phytic acid activated composition C 20 ml Light liquid paraffin 40 g Isopropyl palmitate 10 g Sorbitan monostearate 3.5 g Polyoxyethylene stearyl ether 4.5 g Water 100 ml

Formulation Example 4 (Aerosol) Phytic acid and sodium hydroxide were weighed at a molar ratio of 1: 8, and an appropriate amount of water was added to obtain a phytic acid concentration of 50.
% Phytic acid activating composition D was obtained as an aqueous solution.
This solution was filled in a spray container to prepare an aerosol agent.

Formulation Example 5 (Cream) Phytic acid and sodium hydroxide were weighed at a molar ratio of 1: 8, and an appropriate amount of water was added to obtain a phytic acid concentration of 5%.
A phytic acid activated composition E was obtained as an aqueous solution. The following was weighed according to the prescription and made into a cream by a conventional method.

Formulation Example 6 (Facial cleanser) Using the phytic acid-activating composition B described in Formulation Example 2,
It was weighed according to the following formulation and used as a face wash (facial foam) by a conventional method.

Comparative Preparation 1 (Shampoo) The following formulation was weighed and shampooed by a conventional method. 50% aqueous phytic acid solution 0.2 ml sodium alkyl ether sulfate 16 g lauric acid diethanolamide 4 g propylene glycol 2 g water total amount 100 ml

Comparative Preparation 2 (Cream) Weighed according to the following formulation and prepared into a cream by a conventional method. Potassium stearate 7 g Stearic acid 15 g Glycerin 5 g Water Appropriate amount 100 g

Comparative Preparation 3 (Cream) Weighed according to the following formulation and prepared into a cream by a conventional method. Rice germ oil 1 g Potassium stearate 7 g Stearic acid 15 g Glycerin 5 g Water Appropriate amount total 100 g

Pharmacological and pharmacological test (effects of improving skin keratin and preventing aging) Nude mice aged 5 to 7 weeks were irradiated with ultraviolet rays of 0.05 J / cm ² as UVB once for 5 months, and the total irradiation dose was 4 J. / C
It was set to m ² . Cream 10 of Preparation Example 5 after completion of UV irradiation
0 to 1000 μg was applied to 10 cm ² of the back of the mouse 3 times a week for 10 weeks. After the application period was completed, the mouse was sacrificed and the skin was collected. Diameter of the above cream application part is 1c
hollowed out into a disk of m and silicon (SILFL
O-trademark) was applied and solidified, the silicon film was peeled off from the skin disk to prepare a skin mold. The mold was irradiated with light from a low angle, and the width of the shadow formed by the wrinkles on the cuticles and furrows formed on the mold was indexed to 0 to 4 (Wrinkle index). 0 indicates no wrinkles and 4 indicates the maximum shadow width seen in the test. As a result, by applying the cream, as shown in Table 1, Wri
The nkle index decreased significantly, demonstrating the effect of the cream.

[0021]

[Table 1]

Use Test 1 Test Example 1 (Beautiful Skin Effect) Formulation Example 5 {phytic acid (0.5% as phytic acid),
Rice germ oil 1%}, comparative preparation 2 (phytic acid, rice germ oil not added) and comparative preparation 3 (phytate not added, rice germ oil 1%) cream for 3 female subjects for 7 days each We asked them to try it and evaluated the skin beautifying effect by a questionnaire.
As shown below, in the product of the present invention, the skin beautifying effect remarkably appeared.

Test Subject Trial Preparation Condition of Hand f Comparative Formulation 2 No change, rough condition f Comparative Preparation 3 no change, rough condition f Formulation Example 5 Very smooth condition g Comparative Preparation 2 no change, rough condition g Comparative Formulation 3 slightly smoothed g Formulation Example 5 Very smoothed state h Comparative Formulation 2 as usual, rough condition h Comparative Formulation 3 still unchanged, rough condition h Formulation Example 5 Very smooth and smooth Became a state

Test Example 2 (anti-acne effect) The bath agent described in Formulation Example 3, the cream preparation in Formulation Example 5, and the face cleanser in Formulation Example 6 were distributed to 10 volunteers with acne constitution and were used at appropriate times. When a questionnaire survey was conducted on the following effects, many volunteers answered that they were good or better. In addition, when conducting interviews with Kuroko and others, there were many opinions that the pigment of Kuroko had become thin.

Answer result Strong effect Good Not good (not feeling) Hot bath effect (warm feeling) 5 4 1 Skin refreshing effect after bathing 4 5 1 Itching suppression effect after bathing 6 4 0 Sebum secretion suppressing effect after bathing 3 7 0 Anti-acne effect 5 5 0

[0026]

EFFECTS OF THE INVENTION By using the composition comprising phytic acid and a salt thereof according to the present invention as a skin beautifying agent, it has effects of improving skin keratin and preventing aging, and further suppressing abnormal secretion of sebum and preventing itchiness. It has the effect of suppressing skin refreshing feeling (freshness) and abnormal skin tissue. We provide skin-refining agents for the prevention and treatment of acne, warts and mollusks.

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁶ Identification code Internal reference number FI Technical indication location A61K 7/50 31/66 ADA ADS ADT (72) Inventor Yoshimi Tsurumi Higashi Sotobori-cho, Higashi-ku, Nagoya-shi Address 35 Sanwa Chemical Laboratory Co., Ltd.

Claims (2)

[Claims] 1. An agent for improving skin keratin and an anti-aging agent, which comprises phytic acid and a salt thereof as main components. 2. An anti-acne, wart, and skin moisturizing agent containing phytic acid and a salt thereof as a main component.