JPH0616043B2 - Body fluid test body - Google Patents

Description

The present invention relates to a test body that can easily detect various components mainly in urine in a liquid, and more specifically, since the support is a support made of a water-dispersible substrate, The present invention relates to a body fluid test body that can be discarded in a tray after use.

When discovering, diagnosing, or treating a disease, it is extremely important to know easily and quickly the presence and amount of various components contained in body fluids such as urine, blood, lymph, etc., such as urine or blood. Knowing the amount of glucose in body fluids quickly and easily is essential for the early detection, diagnosis and management of diabetes.

BACKGROUND ART Conventionally, a body fluid inspection body is formed by sticking a mouth paper impregnated with a reagent on a surface of a support made of non-water dispersible plastic such as polystyrene using a double-sided tape or the like.

Further, a body fluid test body in which a reagent is applied to the surface of the support by printing or the like is also used.

As the material of the support in the body fluid test body, polystyrene is conventionally most favored and used because it is inexpensive and has suitable rigidity. However, the support made of these non-water-dispersible materials is very inconvenient for the treatment of the body fluid test body after use. Bodily fluids such as urine, blood and lymph emit a foul odor peculiar to organic substances, and it is inconvenient to dispose of them together with garbage. Therefore, incinerate them in an incinerator etc. in hospitals that use a large amount of specimens for treatment. But
It was very inconvenient in places without such facilities, such as ordinary households.

As a result of intensive studies conducted by the present inventor in view of the above-mentioned drawbacks, the body fluid test body, in which the support is a support made of a water-dispersible substrate, solves the above-mentioned drawbacks and is easily treated by discarding it in a toilet or the like after use. The inventors of the present invention have found that it is a test object that can be used, and have reached the present invention.

That is, the present invention provides a body fluid test body in which a reagent layer for body fluid test is provided on a support, wherein the support is a water-dispersible substrate, and the support is water-dispersible. The gist is a body fluid test body characterized by being formed by laminating a plurality of different water-dispersible base materials. Further, in the above body fluid test body, it is preferable that the support is one in which a water-soluble or water-dispersible paper is laminated with a water-soluble or water-dispersible resin.

Hereinafter, the body fluid test body of the present invention will be described in detail based on Examples.

1 and 2 show an embodiment of the body fluid test body of the present invention, in which 1 is a urine body test body as a body fluid test body.
The inspection body 1 includes a support 2 formed by laminating a plurality of water-dispersible base materials having a planar rectangular shape and different in water dispersibility, and a support 2 on the support 2.
It is composed of a urine test reagent layer 3 provided at a place. The reagent layer 3 in the present embodiment is configured so that one type of urine test items such as glucose detection, protein detection, and PH measurement can be tested.

Examples of the water-dispersible base material forming the support 2 include water-soluble or water-dispersible paper and synthetic resin.

Examples of water-soluble or water-dispersible papers include recycled valves, papers made from papers using water-soluble resins such as carboxymethyl cellulose as binders, and water-soluble or water-dispersible resins such as polyvinyl alcohol. Resins of The support is composed of a plurality of base materials having different water dispersibility so as to maintain a prototype as a test body even when body fluid such as urine is slightly wet, and to maintain a certain degree of rigidity so that it can be handled manually. Generally, if the thickness is the same, the paper material has a higher dispersion speed in water than the synthetic resin base material.

After immersing the urine specimen 1 in the subject, the support 2 needs to be dissolved or not swollen for a predetermined time in consideration of the reaction time of the reagent. Therefore, the thickness of the support 2 is required to be the above. The property is taken into consideration, and it is slightly different depending on the material of the water-dispersible base material forming the support 2.

When the base material is regenerated pulp, 0.1 to 3.0 mm, preferably 0.
2 ~ 2.0 mm, 0.1 ~ 3.0 mm preferably when the substrate is paper made from pulp using a water-soluble resin as a binder
0.2 to 2.0 mm, and 0.1 to 2.0 mm, preferably 0.2 to 1.0 mm when the base material is a water-soluble or water-dispersible synthetic resin.

The reagent layer 3 is selected from, for example, an ink composition for glucose detection, an ink composition for protein detection, an ink composition for urine test such as a pH measurement ink composition, for printing on the surface of the support 2. Therefore, it can be formed by coating.

As the ink composition for forming the reagent layer 3, any conventionally known ink composition for urine detection can be used, but in consideration of the water dispersibility of the support 2, a non-aqueous solvent is used. An ink composition in which a reagent is dispersed or dissolved is preferable,
Taking a glucose detection ink composition as an example, for example, a sugar oxidase such as glucose oxidase, a peroxidase, an oxidizable indicator such as o-tolidine, a binder, a stabilizer and the like are dissolved or dispersed in a non-aqueous solvent. Things are used.

By using the above-mentioned ink composition, when the reagent layer 3 is coated on the support 2, the support 2 made of a water-dispersible substrate is prevented from dissolving or swelling, and a good urine test sample 1 is obtained. Is obtained.

FIGS. 3 and 4 show another embodiment of the urine test body 1 as the body fluid test body of the present invention, in which the reagent composition is dissolved or dispersed on the surface of the support 2 made of a water-dispersible base material. The papers 4, 4 ', 4 "impregnated with the solvent thus prepared are double-sided tapes 5, 5',
The reagent layers 3, 3 ′ and 3 ″ are formed by sticking with 5 ″.

In this embodiment, three types of reagent layers 3, each having different purposes,
3'and 3 "are provided so that, for example, three types of tests such as glucose detection, protein detection, and PH measurement can be performed at the same time.

In order to impregnate the paper sheets 4, 4 ', 4 "forming the reagent layers 3, 3', 3" in this embodiment, the reagent composition is dissolved or dissolved in the non-aqueous solvent in the above embodiment. May be dispersed, but it is also possible to use a solution obtained by dissolving or dispersing the above reagent composition in water or a water-alcohol solvent. Further, the attachment of the mouth papers 4, 4 ', 4 "to the support body 2 is not limited to the use of the double-sided tape 5, 5', 5", and a conventionally known adhesive may be used. It is possible.

FIG. 5 and FIG. 6 show still another embodiment of the urine test body 1 as the body fluid test body of the present invention, in which the support body 3 includes the first layer 6, the second layer 7, and the third layer 8. It has a layered structure.
The material of each of the first layer 6 to the third layer 8 can be appropriately selected from the water-soluble or water-dispersible paper, the synthetic resin, etc. in the above-mentioned embodiment, but the water-soluble or water-dispersible material can be used. It is preferable to use paper for the second layer 7 and a water-soluble or water-dispersible synthetic resin for the first layer 6 and the third layer 8. Although the thickness of each layer varies depending on the material of each layer, in the case of the above configuration, the first layer 6 and the third layer 8 have the same thickness and are 0.005 to 0.5 mm, preferably 0.01 to 0.2 mm,
The second layer 7 has a thickness of 0.1 to 3.0 mm, preferably 0.2 to 2.0 mm.

In this embodiment, the support 2 has a three-layer structure, but the support 2 may be composed of two layers or four or more layers in the present invention. Also in this case, each layer constituting the support 2 is made of water-soluble or water-dispersible paper, synthetic resin or the like, as in the present embodiment.

In using the urinalysis specimen 1 of each of the above-described examples configured as described above, the reagent layer 3 is held by gripping the end portion of the support body 2.
3 ′, 3 ″ is dipped in urine, which is the subject, and the reagent layer 3,
By changing the color of 3 ', 3 ", it is possible to inspect inspection items such as sugar content in urine, the presence or absence of protein, and measurement of PH value.
After use, it can be easily disposed of by discarding it in a toilet or the like.

FIGS. 7 and 8 show still another embodiment of the urine test body 1 as the body fluid test body of the present invention, in which the support 2 is formed by laminating a plurality of water-dispersible base materials having different water dispersibility. It has a cup shape and has three reagent layers 3 on the inner side of the support 2.
3 ', 3 "are printed. When using the urine test sample 1 of the present embodiment, urine as a test object is put in the cup to form the reagent layers 3, 3', 3". After contacting urine, the urine is discharged and each inspection item can be inspected by changing the color of the reagent layers 3, 3 ', 3 ", which is the same as in the above embodiments. As in the above-mentioned respective embodiments, the inspection body 1 can be easily processed by discarding it in a toilet or the like.

Incidentally, in this embodiment, the support 2 can be composed of three or more layers made of a water-dispersible base material as in the above-mentioned respective embodiments, and the material thereof is also the same as in the above-mentioned respective embodiments. Things can be used. Furthermore, in this embodiment, the reagent layers 3, 3 ',
Although 3 ″ is applied by printing, the present invention is not limited to this, and a double-sided tape, a mouth paper impregnated with a reagent by an adhesive or the like can be attached.

In each of the above embodiments, the case where the number of reagent layers is one or three has been described, but the present invention is not limited to this, and two or four or more different reagent layers may be provided if necessary. What can be done is the same as the conventional body fluid test body.
Further, although the urine test body 1 as the body fluid test body has been described in each of the above embodiments, the present invention is not limited to this, of course.
The body fluid test body of the present invention can be used for blood, lymph, etc., which are generally targets of body fluid tests. In that case, the reagent layer may be appropriately selected.

Further, it goes without saying that the material, shape, configuration and the like can be changed without changing the gist of the present invention.

As described above, in the body fluid test body of the present invention, since the support body is formed of the support body made of the water-dispersible base material, it is possible to dispose of it in a toilet or the like after using the test body. It is a very convenient body fluid tester that can be easily processed even in a place without facilities such as an incinerator at home. Furthermore, the body fluid test body of the present invention employs a structure in which a plurality of water-dispersible base materials having different water dispersibility are laminated, so that the water dispersibility can be arbitrarily adjusted, and even when the body fluid is wet, it can be tested. The body principle can be maintained and it can be adjusted so that it completely dissolves when it is discarded in the flush toilet. In particular, when a support is laminated with a water-soluble or water-dispersible resin on one or both sides of water-soluble or water-dispersible paper, a paper having a high dispersion speed and a resin having a slightly low dispersion speed on the paper are Can be easily combined to give moderate water dispersibility

[Brief description of drawings]

The drawings show an embodiment of the present invention. FIG. 1 is a plan view showing an embodiment of the body fluid test body of the present invention, and FIG.
Longitudinal sectional views taken along the line II, FIGS. 3 and 5 are plan views showing another embodiment of the body fluid test body of the present invention, and FIG. 4 is a longitudinal sectional view taken along the line IV-IV in FIG. 5 is a vertical sectional view taken along line VI-VI in FIG. 5, FIG. 7 is a perspective view showing still another embodiment of the body fluid test body of the present invention, and FIG. 8 is a vertical sectional view taken along line VIII-VIII in FIG. It is a figure. 1 ... Urine test body, 2 ... Support body 3, 3'3 "... Reagent layer

Claims (2)

[Claims] 1. A liquid test body in which a reagent layer for body fluid test is provided on a support, wherein the support is a water-dispersible substrate, and the support is water-dispersible. A body fluid test body comprising a plurality of different water-dispersible substrates laminated. 2. The body fluid test body according to claim 1, wherein the support is a water-soluble or water-dispersible paper laminated with a water-soluble or water-dispersible resin on one side or both sides.