JPH0565825B2 - - Google Patents

Description

[Detailed Description of the Invention] [Industrial Application Field] The present invention relates to an automatic analyzer, and particularly to an automatic analyzer that can easily perform biochemical analysis, immunological analysis, blood drug analysis, and even electrolyte testing. This invention relates to an automatic analyzer that can perform multi-purpose and multi-item measurements.

[Prior art and its problems]

Various automatic multi-item analyzers have been proposed in the past, but most of them are structured specifically for biochemical analysis, immunological analysis, or blood drug analysis, or are designed to handle biochemical analysis, immunological analysis, or blood drug analysis. The limit is that it is configured to perform electrolyte testing.

This is because the analysis procedures for biochemical analysis, immunological analysis, blood drug analysis, and electrolyte testing are significantly different, so if these were to be performed on a single automatic analyzer, the equipment would be extremely complicated.・It had the problem of being large and high in cost.

[Purpose of the invention]

This invention was devised in view of the current situation, and its purpose is to perform biochemical analysis,
Immunological analysis, blood drug analysis, and even electrolyte testing can be easily performed using a single device.
Moreover, the present invention aims to provide an automatic analyzer that is simple and compact, and is inexpensive.

[Structure of the invention]

In order to achieve the above object, the present invention provides a turret-shaped sample table that holds a required number of sample containers on the outer circumferential side and a required number of dilution tubes on the inner circumferential side; One has an annular reaction tube holder that is rotatably arranged on the outer periphery and holds the required number of ordinary reaction tubes, and the other has the required number of ordinary reaction tubes.
A reaction table that is detachably replaceable with another annular reaction tube holder holding a reaction tube for EIA analysis, and a first reagent table and a first reagent table placed on both sides of the table. A second reagent table, a pipette support arm whose one end is supported by a shaft erected between the reaction table and the first reagent table are movable up and down, and the other end of the pipette support arm is centered around the shaft. The pipette attached to the other end of the pipette support arm can be rotated to the sample suction position, reaction tube position, and washing position as shown in FIG. A pipette device that can be switched to the electrolyte testing position and moved, and a first reagent for dispensing the required amount of the first reagent in the reagent bottle placed on the first reagent table into the reaction tube according to the measurement item. A pipette device and a second pipette in a reagent bolt placed on a second reagent table.
A second reagent pipette device for dispensing the required amount of reagent into the reaction tube according to the measurement item, and a measuring light beam from a light source located in a support tube disposed at the center of rotation of the sample table. An optical measuring device has a plurality of light-receiving elements arranged outside a reaction table that receives light transmitted through the reaction liquid, and measures the reaction liquid in the reaction tube colorimetrically, and the sample table is intermittently rotated at the required timing. a drive device that controls rotation of the reaction table at a required timing; and a drive device that controls forward and reverse rotation of the first reagent table to transfer a reagent bottle corresponding to a measurement item to a reagent suction position. , a drive device that controls the forward and reverse rotation of the second reagent table to transport the reagent bottles corresponding to the measurement items to the reagent suction position, and a drive device for biochemical analysis, immunological analysis, blood drug analysis, and electrolyte testing. In order to make it possible to switch the analysis operation according to the purpose of use, the apparatus is constructed of a control device containing a computer that controls each of the above-mentioned devices.

〔Example〕

Hereinafter, the present invention will be described in detail based on an embodiment shown in the accompanying drawings.

The automatic analyzer X according to this embodiment includes a turret-shaped sample table 3 that holds a required number of sample containers 1 on the outer circumferential side and a required number of dilution tubes 2 on the inner circumferential side, and the table 3. One has an annular reaction tube holding part that holds the required number of normal reaction tubes 4 rotatably arranged on the outer circumference of the cylinder, and the other holds the required number of reaction tubes for EIA analysis (not shown). A reaction table 5 having an annular reaction tube holding part which can be detachably replaced, and a first reaction table 5 arranged on both sides of the table 5 with the table 5 in a plane shape.
It is attached to the other end of a pipette support arm that is moved up and down and rotated with one end supported by a shaft installed between the reagent table 6, the second reagent table 7, and the reaction table 5 and the first reagent table 6. pipette,
A pipette device 8 that can be moved in multiple stages along the longitudinal direction of the pipette support arm in order to position the pipette at a position corresponding to the measurement item, and a plurality of reagent bottles placed on the first reagent table 6. 9
The first reagent in the reaction tube 4 is added to the reaction tube 4 according to the measurement item.
A first reagent pipette device 10 for dispensing the required amount to
and a second reagent pipette device 12 for dispensing a required amount of the second reagent in the plurality of reagent bottles 11 placed on the second reagent table 7 into the reaction tube 4 in accordance with the measurement item; The reaction liquid in the reaction tube 4 (reacted by adding the first reagent and the second reagent to the serum sample; the same applies hereinafter) is placed in the support tube 38 disposed at the center of rotation of the sample table 3. Optical measuring device 13 that performs colorimetric measurements and has a plurality of light receiving elements arranged outside the reaction table 5, where measurement light from a positioned light source 39 is transmitted through the reaction liquid and received.
, a drive device 14 that rotates the sample table 3 intermittently at required timing, and a first and second
A drive device 1 that controls the forward and reverse rotation of the reagent tables 6 and 7, respectively, and transports the reagent bolts 9 and 11 corresponding to the measurement item to predetermined first and second reagent suction positions.
5, 16, a drive device 17 that controls the rotation of the reaction table 5 at the required timing, two stirring devices 18, 19, a cleaning device 20, a fluorescence detector 21, a device for biochemical analysis, and an immunoassay. In order to be able to switch the analysis operation for chemical analysis, blood drug analysis, and electrolyte testing, the apparatus is comprised of a control device containing a computer that controls each of the above-mentioned devices.

The sample table 3 is supported coaxially with the reaction table 5, and is rotated via a drive device 14 to intermittently transport each sample container 1 one after another to the sample suction position a. Each sample container 1 contains a required amount of a specimen (serum) to be measured. As a matter of course, the dilution tube 2 is also intermittently transferred together with the sample container 1 as the sample container 1 is intermittently transferred.

When a predetermined sample container 1 is transferred to a predetermined sample suction position a in this manner, the required amount of the sample in the sample container 1 is aspirated via the pipette device 8, and then into the corresponding reaction tube 4. Dispensed.

As shown in FIG. 3, the pipette device 8 includes a pipette support arm 23 whose one end is supported by a shaft 22 erected between the reaction table 5 and the first reagent table 6; A pipette 24 is attached to the other end and is movable in multiple stages along the longitudinal direction of the pipette support arm 23, and a reaction tube on the reaction table 5 is connected to the pipette 24 to aspirate the required amount of the sample. 4 or the sampling pump 25 discharging into the dilution tube 2 on the sample table 3, and the other end of the pipette support arm 23 are located above the sample suction position a, the dilution tube position b, the reaction tube position c, or a washing position (not shown). The drive device 26 controls the rotation of the pipette support arm 23 at a predetermined timing about the shaft 22 so that the pipette support arm 23 is in the same position as the pipette support arm 23, and controls the pipette support arm 23 to move up and down at each position.

The method for measuring the required amount of sample by aspirating it into the pipette 24 is to fill the suction system with water, isolate the sample and water via air, and then aspirate and measure the sample.
Only the sample is discharged, and then the inside of the pipette 24 is washed by passing washing water from inside. During this cleaning, the pipette 24 is of course set in a pipette cleaning position (not shown). Note that this pipette 24 is equipped with a suction amount confirmation device (not shown) having a known configuration for checking the amount of sample, etc. sucked up, and detects the absolute amount of sample, etc. every time sampling is performed. , the sample amount is automatically corrected.

Furthermore, as described above, the pipette 24 of this pipette device 8 is slidable along the longitudinal direction of the pipette support arm 23 in accordance with the measurement item as shown in FIGS. 1 and 3, and can be switched in multiple stages. The pipette 24 is moved via a switching device G. This switching device G is composed of a motor m disposed at one end of a pipette support arm 23, and a belt 27 wound around the rotating shaft of this motor m. A pipette holder 29 is inserted through the upper wall surface of the pipette support arm 23 from the upper end of the pipette holder 29, which is slidably inserted into the hollow slot 28a opened along the longitudinal direction of the arm 23 and is not pulled out. The pipette 24 is fixed to a pin 31a protruding from the slot 30, and by rotating and controlling the motor m, the pipette 24 is moved from the tip to one end side (the left end in FIG. 3) at the other end of the pipette support arm 23. from the right end side) to the diluted sample suction device 6.
0, the sample suction/discharge device 61, and the electrolyte testing position 62, and are controlled in three stages so as to be positioned and moved.

Then, the pipette 24 is moved to the diluted sample aspiration position 60.
When the pipette is moved longitudinally to the diluted sample aspiration position 60, the pipette support arm 23 is rotated, and the dilution tube 2 is also intermittently transferred to a predetermined dilution tube position b, the pipette After the support arm 23 is lowered and the required amount of diluted sample is aspirated by the pipette 24, the pipette support arm 23 is raised and rotated to be dispensed into the reaction tube 4 at the corresponding reaction tube position c. Ru.

Furthermore, when the pipette 24 is positioned at the sample aspiration/discharge position 61, the sample aspiration/discharge position 6
1, the pipette support arm 23 is rotated, and the sample container 1 is further transferred to a predetermined sample suction position a on the sample table 3. After being aspirated, the pipette support arm 23 is rotated and dispensed into another reaction tube 4 located at the corresponding reaction tube position c.

Furthermore, after the pipette 24 is first positioned at the sample suction/discharge position 61 and the required amount of the sample in the sample container 1 at the sample suction position a on the sample table 3 is aspirated by the pipette 24, the pipette support arm 23 is raised and the pipette 24 is moved longitudinally from the sample suction/discharge position 61 to the electrolyte testing position 62;
At this electrolyte test location 62, the analyte is drawn into a flow cell (not shown).

The selective suction and dispensing operations of the specimen or diluted specimen by the pipette 24 described above are all performed using a microsyringe based on the operation of the sampling pump 25 connected to one end of the pipette 24 via a conduit (not shown). The pulley is driven by a pulse motor, and the amount of liquid in the syringe is adjusted in accordance with the number of pulses in the pulse motor.

The reaction table 5 is connected to the drive device 17 as described above.
Step rotation or any step reversible rotation can be controlled via. As this drive device 17, a pulse motor is applied. The reaction tube holder that is engaged with the reaction table 5 is formed into a substantially annular shape in plan view, as shown in FIG. and
Slightly above the bottom of each hole 33, a light guiding hole 34 is provided which horizontally penetrates the reaction tube holding section.
A reaction tube 4 formed in the shape of a rectangular cylinder with a bottom and made of hard glass or transparent plastic (chemical-resistant material) is fitted into each of the bottomed holes 33 .

Drive devices 15 and 16 that control the forward and reverse rotation of the first reagent table 6 and the second reagent table 7, respectively, rotate the reagent bottles 9 and 11 containing reagents corresponding to the measurement items to the first reagent table. Transfer to the suction position and the second reagent suction position. Each reagent bottle 9 and 11 arranged on each table 6 and 7 is
The reagent bottles 9 and 11 containing reagents corresponding to the measurement items are set at predetermined positions and stored in memory in a control device with a built-in computer, and are moved to each drive device 1 by operating the control device.
It is operated to transfer at 5,16.

When the reagent bottles 9 and 11 corresponding to the measurement item are thus transferred to the predetermined reagent suction position,
Pipette devices 10, 12 for first and second reagents, respectively
The required amount is poured into the corresponding reaction tube 4 every minute.

The first and second reagent pipette devices 10 and 12 are provided with pipette support arms 51, 51' whose one ends are supported by shafts 28, 28', and the pipette support arms 51, 51' at the other ends. pipettes 53, 53' and these pipettes 53, 5
Reagent pumps 31 and 31' are connected to the pipette support arms 51 and 51', respectively, and are connected to the reagent pumps 31 and 31' for aspirating required amounts of the first and second reagents corresponding to the measurement items and dispensing them into the corresponding reaction tubes 4, and the pipette support arms 51 and 51'. Axis 2 from the reagent suction position to the washing position (not shown) via the reaction tube position c.
The reagents sucked from each pipette 53, 53' move through the suction system flow path with water. The reagent and water are separated by air, and when discharged, only the reagent is pushed out by the reagent pumps 31 and 31', and the inside of the flow path is cleaned with the water filled in the flow path. . At this time, the pipettes 53, 53' are set at the washing position. Although not shown, a heating device and a suction amount confirmation device are installed in the reagent suction channel, which detects the suction amount each time the reagent is sucked up and automatically corrects the reagent amount. It is configured to perform The configurations of the reagent pumps 31 and 31' are similar to the configuration of the sampling pump 25.

The shaft 28 of the first reagent pipetting device 10
is arranged coaxially with the shaft 22 of the pipetting device 8, the pipette support arm 51 is arranged above the pipette supporting arm 23 of the pipetting device 8, as is clear from FIGS. 1 and 3, and The pipette 53 is arranged so as not to interfere with the pipette support arm 23. Further, the pipette 53 is configured to dispense the first reagent into the reaction tube 4 at a position one pitch ahead of the reaction tube 4 at the reaction tube position c, which is dispensed by the pipette 24 of the pipette device 8. has been done.

The stirring device 18 is arranged so as to stir the reaction liquid in the reaction tube 4 at the position where the reaction tube 4 after dispensing the first reagent is transferred one pitch, and the other stirring device 19 2 Reaction tube 4 after dispensing of reagent
The reaction liquid in the tube 4 is stirred at the position where the tube 4 is transferred one pitch.

These stirring devices 18, 19 are provided with arms 5 whose one ends are supported by shafts 54, 54', as shown in FIG.
5, 55', a motor 35, 35' fixed to the upper surface of the arm 55, 55';
35', and vertical stirring rods 36, 36' that extend vertically through the arms 55, 55', and the arms 55, 55'
The arms 55, 55' are normally supported in an upwardly biased state by springs 37, 37' wound around the arms 4, 54', and the arms 55, 55' are supported by springs (not shown). Figure 4 Stirring rod 3 that is normally pulled counterclockwise
6, 36' are biased to the cleaning position. Further, the arms 55, 55' are connected to the first and second arms.
The pipette support arms 51, 51' of the reagent pipette devices 10, 12 are arranged slightly lower than the first and second reagent pipette devices 10, 12, respectively.
As the twelve pipette support arms 51, 51' rotate to the reagent dispensing position of the reaction tube 4, the arms 55, 55' move to the pipette support arms 51, 5.
1' and transferred to the stirring position, after which the pipette support arms 51, 51' are moved to the stirring position.
As the arm 55, 55' descends, the arms 55, 55' are pressed downward against the biasing force of the springs 37, 37'.
The stirring rods 36, 36' are inserted into the reaction tube 4, and the reaction liquid in the tube 4 is stirred. When the reagent dispensing operation by the first or second reagent pipette device 10, 12 is completed and the pipette support arms 51, 51' are raised, the arms 55, 55' are moved as described above.
Since the arms 55 and 55' are urged upward by the springs 37 and 37', the arms 55 and 55' are raised by the urging force of the springs 37 and 37'. Thereafter, the pipette support arms 51, 51' move the pipettes 53, 53' to the washing position, but as the pipette support arms 51, 51' rotate, the arms 55, 55' are moved to the washing position by the spring. It is pulled to a certain point, rotates, and stops at the same position.
Then, when the pipette support arms 51, 51' are lowered, the arms 55, 55' are pressed by the pipette support arms 51, 51' and lowered to the washing position. When the predetermined washing operation is completed, the pipette support arms 51, 55' are lowered to the washing position. With the rising operation of arm 51', arm 55,
55' is configured to be raised by springs 37, 37' and returned to its original position. The cleaning water adhering to the cleaned stirring rods 36, 36' is wiped away by a wiping device.

As shown in FIG. 2, the optical measurement device 13 includes a support tube 3 which is formed in a sealed shape and is disposed below the sample table 3 at the center of rotation of the sample table 3.
8, and a light source 3 disposed in the hollow part of this support tube 39.
9, a plurality of holes 40 opened to guide the measurement light from the light source 39 to the outside of the support tube 38, a condenser lens 41 attached to each hole 40, and the support tube 3
A filter support 44 is supported on the outer circumferential side of the support tube 38 via a bearing 42 and rotates at a constant speed via a drive device 43 on the outer circumferential side of the support tube 38.
and the hole 40 of the support tube 38 is opened in the support body 44.
A filter 46 is attached to a hole 45 coaxial with the filter 46, and the measurement light is converted into a predetermined wavelength by the filter 46, enters the light guide hole 34 of the reaction table 5, and passes through the reaction liquid. It is composed of a plurality of light receiving elements 47 that receive measurement light.

The number of holes 40 opened in the support tube 38 is the same as that of the light receiving element 4.
7 (eight in the illustrated embodiment), and are arranged so as to be located on a straight line connecting the light source 39 and each light receiving element 47, as is clear from FIG.

A plurality of holes 4 formed in the filter support 44
5 are opened at equal intervals along the circumferential direction of the support 44, and each of these holes 45 is equipped with a filter 46 for converting into a different wavelength. The arrangement state of these filters 46 is detected by a position detector 48, and based on the data detected by this position detector 48, light having a wavelength corresponding to the measurement wavelength is input to each light receiving element 47.

As is clear from FIG. 1, the light receiving elements 47 are arranged at equal intervals along the longitudinal direction of the light receiving body 47 arranged on the outer peripheral side of the reaction table 5. Therefore, the measurement light that has passed through the reaction liquid in the reaction tube 4 is received by each light receiving element 47 through the light guide hole 34, and an increase/decrease signal of the light amount conversion voltage is sent to the control device.
Input to CPU.

The fluorescence detector 21 is used when performing EIA testing of solid phase beads, and includes a light source and a filter that converts the light from the light source directly above the reaction solution in the reaction tube 4 to a wavelength (255 nm) for measurement. A quartz fiber that guides light directly downwards, an interference filter that receives 365 nm output light that is irradiated onto the reaction liquid in the reaction tube 4 and exits at right angles to the incident light, a phototube, a detection circuit and control board, and a fluorescence detector control. Since the details of the structure are the same as those of the conventional one, the details will be omitted here.

The cleaning device 20 is configured to perform six-stage cleaning, in which cleaning water is passed through the first or second stage, the other cleaning lines are used for water cleaning, and one of the lines is filled with water, and the reaction tube 4 is flushed with water. Other than being configured to measure its own blank value, the details of its configuration are the same as those of the cleaning device used in known automatic analyzers, so a description thereof will be omitted here.

The control device has a built-in computer, and is equipped with the above-mentioned CPU, keyboard, display, floppy disk driver for switching various programs, and a printer for printing measurement results, as well as the above-mentioned sample table drive device, Controlling the operations of the reaction table driving device, the first reagent table and second reagent table driving devices, the pipetting device, the first reagent pipetting device and the second reagent pipetting device, the optical measurement device, etc.
shall be operated.

Further, the electrolyte testing pump 32 is composed of three types of known standard solution transfer pumps, flow cell draw-in pumps, and waste liquid transfer pumps, and is configured as an independent squeeze pump.

Further, the temperature of the reaction tube 4 is adjusted by circulating temperature-controlled water through a block heater, and the temperature thereof is varied in accordance with the analysis items and the like. The reagent bottles 9 and 11 are kept cool at about 10° C., and a cooling water circulation method is used as the cooling method.

In addition, in FIG. 2, reference numeral 49 indicates sample table 3.
bearing for support, 50 is sample table 3
This is a position detector.

Next, the operation of the automatic analyzer X according to this embodiment will be explained below.

When performing biochemical analysis, a special program (diskette) is set in the floppy disk driver of the control device, and when a start switch (not shown) is turned on, each device is driven by the output signal of the control device. Operate and pipette device 8
The pipette 24 is moved so as to be positioned at the sample suction/discharge position 61, and the pipette support arm 23 is rotated and set at the sample suction position a, and the sample container 1 on the sample table 3 is moved.
After aspirating the required amount of sample from inside, move the reaction tube to position c.
The pipette support arm 23 is rotated and transferred until the required amount of sample is dispensed into the corresponding reaction tube 4. Next, the reaction table 5 displays the reaction tubes 4 into which the specimen has been dispensed.
It is intermittently transferred to the pitch (counterclockwise in FIG. 1), that is, to the first reagent dispensing position. When the reaction tube 4 is transferred to the first reagent dispensing position, the first reagent table 6 is rotationally controlled in synchronization with this, and the reagent bottle 9 containing the reagent corresponding to the measurement item is sucked into the first reagent. A required amount of the first reagent is aspirated by the pipette 53 from inside the bottle 9 via the first reagent pipette device 10, and the first reagent aspirated into the pipette 53 is transferred to the first reagent dispensing position. The required amount is dispensed into the reaction tube 4 that has been moved. Next, the reaction tube 4, which has finished dispensing the first reagent, is intermittently transferred by the reaction table 5 to the stirring position, which is advanced by one pitch. When the reaction tube 4 is transferred to the stirring position, the stirring device 18 is activated and the sample, etc. in the tube 4 is stirred. After this stirring operation has been completed, the reaction tube 4 is then transferred to a second reagent dispensing position a predetermined distance ahead. In synchronization with this, the second reagent table 7 is rotationally controlled, and the reagent bottle 11 containing the second reagent corresponding to the measurement item is transferred to the second reagent suction position, and the second reagent pipette device 12 is used to dispense the required amount. A second reagent is aspirated and dispensed into the reaction tube 4. Next, the second reagent is dispensed, and the reaction tube 4 is further intermittently transferred one pitch by rotation of the reaction table 5 until it reaches the stirring position, and the reaction liquid in the reaction tube 4 is stirred by the stirring device 19. Next, this reaction tube 4 is intermittently transferred by one pitch, and the colorimetric measurement of the reaction liquid in the tube 4 is immediately performed by the optical measuring device 13. This colorimetric measurement is carried out several times (a total of 8 times in the illustrated example) at regular pitch intervals after the reaction tube 4 has been transferred to the initial measuring position.
In this case, reaction time course data can be obtained by detecting only the wavelength corresponding to the measurement item at each stage, or desired data can be obtained by performing various combination analyzes at each stage. After the predetermined colorimetric measurement operation has been completed, the reaction tube 4 is transferred to a cleaning position, where the reaction tube 4 is cleaned by a cleaning device 20 and provided for reuse.

Incidentally, when performing this biochemical analysis, the dilution tube 2 can also be used as a reagent blank, standard, quality control, or emergency specimen.
Of course, in this case, the pipette 24 of the pipetting device 8 is switched to the diluted sample aspiration position 60 by the control device. Furthermore, the inner dilution tube 2 can also be used for general samples.

When performing immunological analysis, set a dedicated immunological analysis program (diskette) in the floppy disk driver of the control device and turn on the start switch.The output signals from the control device will drive each device. During operation, the pipette 24 of the pipette device 8 is first moved to be positioned at the sample suction/discharge position 61, and the pipette support arm 23 is rotated and set at the sample suction position a, and the pipette 24 is removed from the sample container 1. Aspirate the required amount of specimen. When this sample aspiration work is completed, the control device moves the pipette 24 to the diluted sample aspiration position 60.
The aspirated sample is moved to the dilution tube position b, and the aspirated sample is discharged into the dilution tube 2 along with the required amount of the primary dilution liquid, and the sample is adjusted to a predetermined magnification. Make the first dilution. The pipette 24 again aspirates the required amount of the first diluted sample diluted to a predetermined ratio.
4 and rotate the pipette support arm 23 to the reaction tube position (first position in biochemical analysis).
(reagent addition position) and dispenses the required amount of primary dilution liquid into the corresponding reaction tube 4. The subsequent operations are roughly the same as those for the biochemical analysis described above. Of course, it is the reagent bottle 1 that is dispensed at the second reagent dispensing position.
This is a secondary dilution liquid corresponding to the measurement item contained in the second dilution liquid.

Next, use this device X to test electrolytes (Na, K, Cl)
To do this, set a special program for electrolyte testing (diskette) in the floppy disk driver of the control device, turn on the start switch, drive and operate each device using the output signal of the control device, and start the pipetting device 8. pipette 24
is first moved so that it is positioned at the sample aspiration/discharge position 61, and the pipette support arm 23
is rotated and set at the sample suction position a, and aspirates the required amount of specimen from the sample container 1. When this sample aspiration operation is completed, the control device switches and moves the pipette 24 so that it is positioned at the electrolyte testing position 62, and the aspirated sample is drawn into a flow cell (not shown) and a predetermined analysis operation is carried out. It will be done.

Next, when performing EIA analysis of the bead solid phase using this device

Further, the reaction tube 4 described above is replaced with a reaction tube containing beads having a larger size, and the reaction table is replaced with a reaction table having another annular reaction tube holder that holds this reaction tube.

In this way, when the start switch is turned on, each device is driven and operated by the output signal of the control device, and the sample and reagent are subjected to known bead solid phase analysis processing (batch processing), and the fluorescence detector 2
Optical measurement processing is performed in step 1.

〔Effect of the invention〕

As explained above, the automatic analyzer according to the present invention allows the reaction table to be exchanged between normal analysis and EIA analysis, changes the pipette position of the pipette device, and changes the operating state of the same device to a floppy disk drive. By simply installing dedicated programs for biochemical analysis, immunological analysis, blood drug analysis, electrolyte testing, etc., you can easily switch between the programs, so you can easily switch between different types of equipment without increasing the size of the equipment. Analysis can be easily performed using one device, and the device is simple and can be provided at low cost.

[Brief explanation of the drawing]

The drawings show an embodiment of the present invention, in which FIG. 1 is a plan view showing the overall configuration of an automatic analyzer according to this embodiment, FIG. 2 is an enlarged sectional view taken along the line of FIG. The figure is a sectional view showing the structure of the pipette device and the first reagent pipette device, and FIG. 4 is a perspective view showing the structure of the reagent pipet device and the stirring device. [Explanation of symbols], X... Automatic analyzer, 1...
Sample container, 2... Dilution tube, 3... Sample table, 4... Reaction tube, 5... Reaction table, 6
...First reagent table, 7...Second reagent table, 8...Pipette device, 9, 11...Reagent bottle, 10...First reagent pipette device, 12...
Second reagent pipette device, 13... Optical measuring device, 14... Sample table driving device, 15...
...first reagent table drive device, 16...second reagent table drive device, 17...reaction table drive device.

Claims (1)

[Claims] 1. A turret-shaped sample table that holds the required number of sample containers on the outer periphery and the required number of dilution tubes on the inner periphery, and a turret-shaped sample table that is rotatably arranged on the outer periphery of the table and holds the required number of normal reactions. One with an annular reaction tube holder holding the tube and the required number of tubes.
A reaction table that is detachably replaceable with another annular reaction tube holder holding a reaction tube for EIA analysis, and a first reagent table and a first reagent table placed on both sides of the table. A second reagent table, a pipette support arm whose one end is supported by a shaft erected between the reaction table and the first reagent table are movable up and down, and the other end of the pipette support arm is centered around the shaft. The pipette attached to the other end of the pipette support arm can be rotated to the sample suction position, reaction tube position, and washing position as shown in FIG. A pipette device that can be switched to the electrolyte testing position and moved, and a first reagent for dispensing the required amount of the first reagent in the reagent bottle placed on the first reagent table into the reaction tube according to the measurement item. A pipette device and a second pipette in a reagent bolt placed on a second reagent table.
A second reagent pipette device for dispensing the required amount of reagent into the reaction tube according to the measurement item, and a measuring light beam from a light source located in a support tube disposed at the center of rotation of the sample table. An optical measuring device has a plurality of light-receiving elements arranged outside a reaction table that receives light transmitted through the reaction liquid, and measures the reaction liquid in the reaction tube colorimetrically, and the sample table is intermittently rotated at the required timing. a drive device that controls rotation of the reaction table at a required timing; and a drive device that controls forward and reverse rotation of the first reagent table to transfer a reagent bottle corresponding to a measurement item to a reagent suction position. , a drive device that controls the forward and reverse rotation of the second reagent table to transport the reagent bottles corresponding to the measurement items to the reagent suction position, and a drive device for biochemical analysis, immunological analysis, blood drug analysis, and electrolyte testing. 1. An automatic analyzer comprising: a control device having a built-in computer that controls each of the above-mentioned devices in order to be able to switch analysis operations according to the purpose of the analysis.