JPH0526883A - Automatic analyzer - Google Patents

Abstract

PURPOSE:To make the number of analysis processing around twice reduce the time of the analysis processing to approximately 1/2 and obtain the analyzer capable of processing measurement items in which a reaction time is long. CONSTITUTION:The automatic analyzer A is composed of reaction vessel holders for holding reaction vessels 5 of the required number with the use of two reaction lines coaxially arranged for holding the reaction vessel 5 in the form of a loop and constituted of transferring the reaction vessel 5 held on these reaction lines through an exchange devices 30, 40 to the opposite reaction lines at the specified position. The reaction vessels 5 are transferably driven and controlled in a mode different from the opposite reaction lines with the use of a drive device individually separating each reaction line from the opposite reaction lines and a reaction presentation state of each reaction vessel 5 held on each reaction line is measured with an optical measurement device 7.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an automatic analyzer for biochemical analysis and immunological analysis, and in particular, it speeds up the analysis processing time in this kind of automatic analysis and gives a reliable measurement accuracy. The present invention relates to an automatic analyzer capable of dramatically improving performance and capable of processing analysis of 600 tests or more per hour.

[0002]

2. Description of the Related Art Conventionally, various types of automatic analyzers have been proposed, but many of them have been designed such that a reaction container is held in series in a loop-shaped reaction container holder. Since most of them are configured, when the number of analysis processes per hour is set to, for example, 600 samples or more, the diameter of the reaction container holder becomes large, which causes a problem that the device becomes significantly large. Had.

Further, among the above-mentioned conventional automatic analyzers,
Although it has been proposed that the reaction vessel holders are arranged in two rows, in this conventional automatic analyzer having two reaction lines, each line is independently driven and controlled, so that each reaction line is Along the way, for example, a sampling device, a reagent device, an optical measuring device, etc. must be arranged,
It is possible to obtain analytical data in correspondence with the reaction time, for example, the equipment becomes complicated, large-sized, and costly high, and the processing time of the one-reagent system and the two-reagent system are exactly the same. I had a problem that I could not.

[0004]

SUMMARY OF THE INVENTION The present invention was devised in view of the present situation, and an object thereof is to significantly improve the number of sample treatments per unit time, and to provide a cell blank and a cell blank. In addition to being able to dramatically improve the reliability of measurement accuracy by measuring a sample blank, depending on the measurement item, it is intended to provide a small automatic analyzer that can obtain analysis results in an extremely short time. is there.

In order to achieve the above object, in the automatic analyzer according to the present invention, reaction container holders for holding a required number of reaction containers are arranged coaxially for holding the reaction containers in a loop. 2 reaction lines, and the reaction container held in each of these reaction lines is configured to be transferred to the other reaction line at a predetermined position through an exchange device, and each of the above reaction lines is The reaction vessel is drive-controlled so as to be transferable in a mode different from that of the other reaction line by a drive device independent of the other reaction line,
In addition, the color reaction state of each reaction container held in each reaction line is measured by one optical measuring device.

Further, according to the present invention, a pipette for dispensing a reagent into each of the reaction vessels corresponding to the above configuration is provided.
It is characterized in that drive control is performed so that a reagent can be selectively dispensed into each reaction container held in the two reaction lines.

Further, according to the present invention, for example, in order to further miniaturize an automatic analyzer capable of performing a large-scale analysis process of 600 tests or more per hour, a reaction line holding a required number of reaction vessels is used. In an automatic analyzer including a reagent dispensing device that dispenses a reagent corresponding to a measurement item into a reaction container, and an optical measuring device, the reaction line is a loop of a required number of reaction containers. The reagent bottle, which is composed of two coaxially arranged lines for holding, and in which the reagent is stored, is arranged in an arc shape along the outer peripheral side of the reaction line, and It is characterized in that it is arranged so as to be movable along the outer peripheral side.

[0008]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention will be described in detail below with reference to an embodiment shown in the accompanying drawings.

As shown in FIGS. 1 to 4, an automatic analyzer A according to this embodiment has a plurality of sample containers 1 in which a sample (serum) to be measured is stored, and the sample containers 1 are endless belts. The snake chain 2 that is held in a fixed shape and the sample container 1 that is held by the snake chain 2 at the sample suction position a at a predetermined intermittent transfer timing.
A known drive device (not shown) for sequentially transferring the sample to the sample suction position a and a corresponding reaction of the outer holder 10 constituting one reaction line by sucking a required amount of sample from the sample container 1 transferred to the sample suction position a. A sampling pipette device 4 for dispensing into a container 5, an outer holder 10 for holding a required number of the reaction containers 5, and an inner holder 20 constituting the other reaction line disposed inside the outer holder 10, Exchange devices 30 and 40 for transferring the reaction vessels 5 of the outer holder 10 and the inner holder 20 at predetermined positions, and a predetermined amount of a reagent corresponding to a measurement item to be sucked and dispensed into the reaction vessel 5 at a predetermined position. Reagent dispensing devices 6 and 6 ', and an optical measuring device 7 for optically measuring a reaction between a sample and a reagent after a lapse of a predetermined time at a predetermined wavelength.
And a cleaning device 8 for cleaning the reaction container 5 for which the optical measurement work has been completed.

The sample container 1 is made of a material such as synthetic resin and has a cylindrical shape with a bottom. For example, 100 pieces are held by the snake chain 2. In addition, this sample container 1
A label (not shown), which is a bar coded and printed information (for example, patient registration number, examination type, hospital code, etc.) related to the stored sample, is attached to the outer peripheral surface of the information. Not read by the barcode reader at the time of sampling and automatically input to the control device.

Each of the snake chains 2 is formed by connecting independent ones in an endless manner, and holds the sample container 1 and sequentially transfers it to the sampling position a.

The sampling pipette device 4 has four arms 4b extending radially from a shaft 4a, and a pipette 4c is arranged at the other end of each arm 4b. A sampling pump for sucking a required amount of sample at a position of 1a and discharging it at a position of b is connected and connected, and each pipette 4c is connected to the washing position c from the sample suction position a through the sample dispensing position b. Rotation is controlled around 4a at a predetermined timing. Of course, in the sampling pipette device 4, the shaft 4a
1 may be configured to be movable in the front-rear direction of FIG. 1, and the aspirated sample may be dispensed into the reaction container 5 reaching the sample dispensing position b ′ of the inner holder 20. Of course, the automatic analyzer of the present invention is not limited to the sampling pipette device having the above-mentioned configuration, and other known sampling pipette devices may be applied.

In this sample measuring method, the wicking system is filled with water, the sample and water are suctioned and measured in a state of being separated from each other via air, and then only the sample is discharged, and then the sample is washed from the inside. The inside of each pipette 4c is washed with water. The pipette 4c is provided with a suction amount confirmation device (not shown) having a known configuration for confirming the suction amount of the sample or the like, and detects the absolute amount of the sample or the like each time sampling is performed. If the sample volume is insufficient, this will be corrected automatically.

As shown in FIG. 2, the reaction vessel 5 is formed of a transparent synthetic resin or the like into a polygonal shape (in the illustrated embodiment, a substantially octagonal shape), and its outer surface is made of magnetized metal. The holder 5a is fitted. The bottom surface of the holder 5a has a hole 5b through which the measurement light of the optical measuring device 7 is transmitted.
Has been established.

Of course, the entire reaction container 5 may be formed of a metal or a magnet adsorbing material, but it is assumed that at least the portion of the optical measuring device 7 through which the measurement light is transmitted is transparent.

Each of the reaction vessels 5 formed in this manner has 49 loops, which is one less than the number of the holding holes formed in the outer holder 10 and the inner holder 20, respectively.

The outer holder 10 is formed in a ring shape, and the outer holder 10 is provided with 50 bottomed holding holes 11 into which the reaction vessels 5 are fitted and held at predetermined intervals. Further, a measurement light transmitting hole (not shown) is formed in the portion where the holding hole 11 is opened so as to be coaxial with the measurement light transmitting hole 5b of the holder 5a, and the measurement light transmitting hole is formed. The required number of holes are also provided between the holding holes 11 at equal intervals.

The outer holder 10 thus constructed
Are transferred in the clockwise direction in FIG. 1 via a known drive device (not shown) such as a pulse motor.

As a mode of transferring the outer holder 10, the reaction containers 5 may be transferred intermittently by one pitch (container), or may be transferred by rotating stepwise by a predetermined number of containers.

As a mode of step rotation, the outer holder 10 is rotated in the clockwise direction in FIG.
7.2 ° step rotation, and as a result, the reaction container 5 is intermittently transferred by one pitch in the clockwise direction in FIG. 1 for each step rotation, and the outer holder 10 is 49 containers in the counterclockwise direction in FIG. In other words, 352.8 degrees step rotation transfer,
Therefore, as a result, the reaction vessel 5 held by the outer holder 10 is moved in the direction opposite to the transfer direction of the outer holder 10.
Either one of the modes in which the pitch (one container) is intermittently transferred can be selected and adopted. Of course, this step rotation form is conventionally known, and therefore a detailed description thereof will be omitted here.

The holding hole 11 is formed to have substantially the same outer shape as that of each holder 5a. On the inner holder side, as shown in FIG.
Each of the holding holes 11 is provided with a permanent magnet or an electromagnet (not shown) having a known structure. There is. Further, on the outer peripheral wall side of the holding hole 11, the reaction vessel 5 is held in the holding hole 2 of the inner holder 20 at the position f in FIG.
Piston rod 31 of the exchange device 30 that pushes and transfers to 1
Holes 12 are formed in the respective holes 12 for appearing and disappearing.

The inner holder 20 is, as described above,
It is arranged inside the outer holder 10, and is formed in a ring shape having a smaller diameter than the outer holder 10. The inner holder 20 is also provided with the same number of bottomed holding holes 21 as the outer holder 10 at which the reaction vessels 5 are fitted and held at predetermined intervals.
In addition, a measurement light transmission hole (not shown) is formed in the portion where the holding hole 21 is formed so as to be coaxial with the measurement light transmission hole of the outer holder 10, and the measurement light transmission hole is formed. The required number of holes are also provided between the holding holes 21 at equal intervals.

The inner holder 20 is moved in the clockwise direction in FIG. 1 via a driving device (not shown).

As a mode of transferring the inner holder 20, the reaction containers 5 may be transferred intermittently by one pitch (container), or may be transferred by rotating stepwise by a predetermined number of containers.

As for the mode of step rotation, as in the case of the outer holder 10, the inner holder 20 is stepwise rotated by 51 containers in the clockwise direction in FIG. 1, that is, 367.2 degrees, and as a result, the reaction container 5 is rotated. Fig. 1 for each step rotation
The inner holder 20 is intermittently transferred by one pitch in a clockwise direction, and the inner holder 20 is transferred in the counterclockwise direction in FIG. 1 by 49 containers, that is, 352.8 degrees step rotation, and thus the reaction container 5 held by the inner holder 20 is transferred. As a result, one pitch (one container) in the direction opposite to the transfer direction of the inner holder 20.
Either one of the modes of intermittent transfer can be selected and adopted. Of course, this step rotation form is conventionally known, and therefore a detailed description thereof will be omitted here.

The holding holes 21 are formed to have substantially the same outer shape as each reaction vessel 5, and the outer holder side thereof is opened so that the reaction vessels 5 can be put in and taken out, as shown in FIG. At the same time, a permanent magnet or an electromagnet (not shown) having a known structure is disposed on the inner peripheral wall side of each holding hole 21.

On the inner peripheral wall side of the holding hole 21, the piston rod 4 of the exchange device 40 for pressing and transferring the reaction container 5 to the holding hole 11 of the outer holder 10 at the position of FIG.
Holes 22 for allowing the 1's to appear in and out are respectively provided. Therefore, the holding hole 11 of the outer holder 10 and the holding hole 21 of the inner holder 20 are formed so that their openings face each other.

In the illustrated embodiment, the outer holder 10
The case where a magnetic material is provided on the wall surfaces of the holding holes 11 and 21 of the inner holder 20 has been described as an example. However, the outer holder 10 and the inner holder 20 as a whole may be magnetized to adsorb and hold the reaction vessel 5. Of course, it may be configured as follows.

The exchanging devices 30 and 40 are composed of actuators having a known structure, as shown in FIG. 3, and the piston rod 31 of the exchanging device 30 is shown in FIG.
The reaction vessel 5 held by the outer holder 10 at the position of is moved to the inner holder 20, and the piston rod 41 of the exchanging device 40 changes the reaction vessel 5 held by the inner holder 20 at the position of FIG. The drive is controlled so as to be changed to 10.

Reagent dispensing devices 6, 6'for dispensing reagents corresponding to measurement items are reagent bottles 60, 60 'arranged in an arc shape along the outer peripheral side of the outer holder 10.
Is movably arranged along the outer peripheral side of the outer holder 10 so as to reach the first reagent suction position e and the second reagent suction position h.

The reagent dispensing device 6 sucks the reagent in the reagent bottle 60 at the first reagent suction position e, and then the reaction container 5 held by the holders 10 and 20 at the first reagent dispensing positions d and d '.
In addition, the reagent dispensing device 6'is
After sucking the reagent in 0 ′ at the second reagent suction position h,
Dispensing into the reaction container 5 held by the holders 10 and 20 at the reagent dispensing positions g and g '.

The reason why the second reagent is added after the reaction container 5 is transferred and held by the inner holder 20 is to measure the sample blank when the reaction with the first reagent is completed. The necessary measurement value is corrected according to the sample blank value.

The reagent bottles 60 and 60 'respectively accommodate a first reagent bottle and a second reagent corresponding to the measurement item, and the first reagent is always kept at 8 ° C to 1 ° C by the first reagent cooler 61.
The second reagent is kept cold at 0 ° C., and the second reagent is kept cold at 8 ° C. to 10 ° C. at all times by the second reagent cool box 61 ′.

As shown in FIG. 1, the reagent bottles 60 and 60 'are controlled to reciprocate on the basis of a command from the control section 74, and the reagent bottle corresponding to the measurement item is moved to the reagent suction position e or h.
Transfer to. As the transfer means for transferring the reagent bottles 60, 60 ′ to the reagent suction position e or h, for example, a known moving mechanism such as a slide rail and a step motor drive can be applied. The first and second reagent bottles are set in predetermined positions and stored in the control device.

Next, the reagent dispensing device 6 is composed of an arm 6b which rotates about a shaft 6a and a pipette 6c which is arranged at the other end of the arm 6b. , After sucking a required amount of the first reagent at the reagent suction position e, the suction reagent is heated to remove the first reagent from the reagent dispensing position d of the outer holder 10 and / or the inner holder 2
The rotation is controlled so as to dispense to the reagent dispensing position d ′ of 0. Of course, the pipette 6c is transferred to the washing position m after the reagent is dispensed, and the washing operation is performed.

Further, the reagent dispensing apparatus 6'is constructed so that the stirring member 9 is disposed on the arm 6b 'to perform stirring work at the position of FIG. 1i, and the sucked second reagent is stored in the outer holder. The reagent dispensing device 6 is configured in the same manner as the reagent dispensing device 6 except that the reagent dispensing position g of 10 and / or the reagent dispensing position g ′ of the inner holder 20 is configured. The same components are assigned the same reference numerals as those used in the reagent dispensing device 6, and detailed description thereof will be omitted here.

The stirring member 9 is driven integrally with the arm 6b ', and a known stirring rod is immersed in the liquid to stir it. Of course,
The stirring rod is washed after the stirring operation.

In the measuring method of the above reagent, the wicking system is filled with distilled water, the reagent and the distilled water are suctioned and measured in a state of being separated from each other through air, and then only the reagent is discharged. The inside of each pipette 6c, 6c 'is washed from the rear inside through washing water, and the outside is washed with distilled water.

Further, the pipettes 6c and 6c 'are provided with a suction amount confirmation device (not shown) having a known structure for confirming the suction amount of the reagent, and the reagent is sucked every time the reagent is sucked. Is detected, and if the reagent amount is insufficient, this is automatically corrected.

As shown in FIG. 1, the optical measuring device 7 for forming the detecting portion or the observation point compares the reaction state of the reaction container 5 held by the outer holder 10 and / or the inner holder 20 at a predetermined position. The measurement is performed by the light source 70 in the same manner as the configuration and operation of a known diffraction grating type optical measuring device.
An optical system 71 that collects the measurement light emitted from the light source 70, a light dispersion element 72, and a light receiving element 73 that receives the amount of light after the measurement light has passed through the reaction container 5 at predetermined wavelengths.
, And 49 reaction vessels 5 are measured by one rotation operation of the holders 10 and 20, and each reaction vessel 5 is optically measured 49 times at a constant time interval. , Get a time course of reaction.

As shown in FIG. 4, the quantity of light of the wavelength corresponding to the measurement item received by the light receiving element 73 is converted into a voltage and the analysis value thereof is processed, and a memory for storing the measurement result is stored. Section 75, an operation section / display 76 for performing all operations of the automatic analyzer A, a printer 77,
Is calculated by a data processing device composed of, and the result is output by the printer 77. The control unit 74 controls each operation of the automatic analyzer A, calculates a measurement signal, and determines the result.

Therefore, for example, in the case of performing the measurement of one reagent system and the step rotation control of the outer holder 10 and the inner holder 20 is performed independently of each other, each of the outer holder 10 and the inner holder 20 is controlled. The transfer timing is shifted so that the measurement light transmitting holes formed in the holding holes 11 and 21 do not match, and the holding hole 11 of the outer holder 10 is different from the measurement light transmitting hole formed in the holding hole 21 of the inner holder 20. Inner holder 20
Other measurement light of the outer holder 10 that is different from the measurement light transmission hole formed in the holding hole 11 of the outer holder 10 by making the holding hole 21 of the inner holder 20 coincide with the optical axis of the other measurement light transmitting hole. By matching the optical axis of the transmission hole,
Optical measurement of each specimen sample in the reaction container 5 held by the outer holder 10 and the inner holder 20 can be continuously performed.

In FIG. 4, reference numeral 78 is a stabilizing power source, and 79
Is a power source, 80 is a cold insulation control unit of the first and second reagent cold storages 61, 61 ', and 81 is a constant temperature for heating and holding the reaction liquid in the reaction container 5 held by the outer holder 10 and the inner holder 20 at the living body temperature. The respective control units are shown.

The cleaning device 8 is configured to perform cleaning work in nine steps from the j position to the k position of the inner holder 20, and the reaction liquid is sucked and discarded at the j position. Injecting and discarding wash water in the second step, injecting wash solution in the third step, leaving injection fluid in the fourth step, discarding wash solution in the fifth step, sucking wash water in the sixth to ninth steps Discarded. The water blank of the reaction vessel 5 into which the cleaning water has been injected in the seventh step is measured as the inner holder 20 is rotated, and is used as a cell blank value for correcting the measured value. Of course, this cleaning device 8
In order to wash the reaction container 5 of the outer holder 10, it is also possible to have a cleaning mechanism similar to the cleaning mechanism of the inner holder 20.

The reaction liquid is discarded and the cleaning liquid / cleaning water is injected / discarded by a cleaning pipe of a known cleaning drive unit (not shown), and the cleaning liquid / cleaning water is sent from the reaction container cleaning pump.

Next, in the automatic analyzer A having the above structure, the outer holder 10 is intermittently transferred by one pitch in the clockwise direction in FIG. 1, and the inner holder 20 is moved in the counterclockwise direction in FIG. 1 by 49 containers, that is, 352.8. The operation in the case of stepwise rotation transfer will be described.

When the start switch (not shown) is turned on, the sample container 1 held by the snake chain 2 is transferred to the sample suction position a, and the serum sample in the sample container 1 at the sample suction position a is sampled by the sampling pipette device. After the required amount is aspirated via 4, the serum sample is dispensed into the reaction container 5 held by the outer holder 10 at the sample dispensing position b.

The reaction container 5 into which the serum sample has been dispensed in this manner is intermittently transferred to the first reagent dispensing position d by one pitch at a time and corresponds to the measurement item via the reagent dispensing device 6 at the same position d. The required amount of the first reagent is dispensed.

Thereafter, the reaction container 5 into which the first reagent has been dispensed is intermittently transferred to the position f while being held by the outer holder 10, and at the position f, the reaction container 5 is replaced by the exchange device 30. It is transferred to the inner holder 20 via.

The reaction container 5 thus transferred to the inner holder 20 is intermittently transferred by one pitch in a direction (counterclockwise direction in FIG. 1) opposite to the rotation direction (clockwise direction in FIG. 1) of the inner holder 20. After the second reagent corresponding to the measurement item is dispensed in the required amount through the reagent dispensing device 6 ′ at the position of FIG. 1g, and after the bubble stirring by the stirrer 9 is performed at the position i one pitch upstream. The reaction state of the reaction liquid in the reaction container 5 is colorimetrically measured by the optical measuring device 7.
In addition, as described above, the reaction container 5 is used as the outer holder 10.
The sample blank is measured by the optical measuring device 7 in the reaction container 5 after the transfer from the inner holder 20 to the second holder until the second reagent is dispensed.

The reaction container 5 for which the measurement by the optical measuring device 7 has been completed is then transferred to the cleaning device 8 for cleaning the inside thereof, and the reaction container 5 for which this cleaning has been completed is replaced by the exchange device 40 at the position of FIG. Is transferred from the inner holder 20 to the outer holder 10 by the sample dispensing position b
Is intermittently transferred to.

Therefore, the automatic analyzer A according to this embodiment is
In that case, the number of sample treatments per unit time is significantly improved, and further, it is possible to measure the cell blank and the sample blank and dramatically improve the reliability of the measurement accuracy. Since 60 'is arranged so as to be movable along the outer circumference of the outer holder 10, the width of the device can be made significantly smaller than that of the conventional automatic analyzer, and can be easily installed even in an inspection room with a small installation space. be able to.

Of course, the transfer mode of the reaction container 5 is only one example as described above in the present invention, and for example, for the analysis item of one reagent system, the outer holder 1 is used.
0 and the inner holder 20 are intermittently transferred, for example, in the same direction by one pitch at a time, or by inputting a command to the control unit 74 so as to rotate stepwise in the same direction. Compared with the number of items, it is possible to obtain twice the processing capacity, and it is also possible to reduce the time required for analysis processing to about 1/2. At this time, the sampling pipette device 4, the reagent dispensing devices 6, 6 ′, and the cleaning device 8 are drive-controlled so that the reaction container 5 of each holder 10, 20 performs a predetermined operation at a predetermined position.

In the case of an analysis item having a long reaction time, for example, after the reaction container is transferred from the outer holder 10 rotating in steps to the inner holder 20 rotating in steps, the reaction container 5 is shown at a predetermined position. Not third
By changing the inner holder 20 to the outer holder 10 again by the exchange device, the reaction container 5 can be transferred between the holders 10 and 20, so that various types of analysis can be performed automatically. It can be performed by the device, and the equipment cost is significantly reduced.

In the above embodiment, the case where one reaction container 5 is replaced with the outer holder 10 or the inner holder 20 has been described as an example. However, the present invention is not limited to this, and for example, two containers can be used. It is possible to double the number of processes per unit time by arranging so that they are exchanged at the same time. Of course, in this case, the number of reaction vessels and each device such as a sampling pipette device and a reagent dispensing device are required to be doubled. In addition, two optical measuring devices, one for the outer holder 10 and one for the inner holder 20, are used, and the coloring state of the serum sample in the reaction container 5 held by the outer holder 10 or the inner holder 20 is measured by an independent optical measuring device. It can also be configured to.

[0056]

INDUSTRIAL APPLICABILITY As described above, according to the present invention, a reaction vessel can be transferred by two reaction lines and can be transferred to a partner reaction line at a predetermined position. The transfer form of the reaction container can be selected, and correspondingly, the optical measurement of each sample held in each reaction line can be continuously performed, so the number of sample processes per unit time can be significantly increased. Depending on the measurement item, the number of analysis processes can be doubled, and the analysis process time can be halved, and it can handle measurement items with long reaction times. Moreover, since the cell blank and the sample blank of the reaction container held in the holder of 1 can be measured, the reliability of the measurement accuracy in the automatic analyzer can be dramatically improved. It can be further, by movably disposed along the reagent bottle on the outer periphery of the outer holder, an excellent effect such as can be greatly reduced width dimension of the mass processable automatic analyzer.

[Brief description of drawings]

FIG. 1 is an explanatory diagram schematically showing the overall configuration of an automatic analyzer according to an embodiment of the present invention.

FIG. 2 is an exploded perspective view of a reaction container and a holder.

FIG. 3 is a plan view showing the details of each configuration of an outer holder and an inner holder with a part thereof cut away.

FIG. 4 is a block diagram showing a driving principle of an automatic analyzer.

[Explanation of sign]

A automatic analyzer a Sample suction position b Sample dispensing position d, d'first reagent dispensing position f, l Reaction vessel replacement position g, g'second reagent dispensing position 1 sample container 5 reaction vessels 6,6 'Reagent dispensing device 7 Optical measuring device 10 Outer holder 11 Outer holder holding hole 20 Inner holder 21 Inner holder holding hole 30,40 exchange device

Claims (3)

[Claims] 1. A reaction vessel holder for holding a required number of reaction vessels is composed of two coaxially arranged reaction lines for holding the reaction vessels in a loop shape, and each reaction line is held by each of these reaction lines. The reaction vessel is configured to be transferred to a reaction line of the other party at a predetermined position via an exchange device, and each reaction line is connected to the other reaction line by a drive device independent of the other reaction line. An automatic analyzer characterized by being driven and controlled so as to be transferable in a mode different from that of a reaction line, and measuring a color reaction state of each reaction container held in each reaction line by one optical measuring device. 2. The pipette for dispensing a reagent into each reaction container is drive-controlled so that the reagent can be selectively dispensed into each reaction container held in the two reaction lines. Automatic analyzer. 3. An automatic analyzer comprising a reaction line holding a required number of reaction containers, a reagent dispensing device for dispensing a reagent corresponding to a measurement item in the reaction container, and an optical measuring device. In the above, the reaction line is composed of two coaxially arranged lines that hold a required number of reaction vessels in a loop, and the reagent bottle containing the reagent is the outer peripheral side of the reaction line. An automatic analyzer characterized in that it is arranged in a circular arc shape along with and is movably arranged along the outer peripheral side of the reaction line.