JPH04305512A - External preparation for skin - Google Patents

Abstract

PURPOSE:To obtain an external preparation for skin effective for preventing and ameliorating chapped skin and preventing the sagging of skin and loss of skin luster to prevent the aging of skin by compounding vitamins to an extract of a plant of genus Melissa, family Labiatae. CONSTITUTION:The objective preparation can be produced by compounding (A) preferably 0.005-15wt.% (based on the whole preparation) of an extract obtained by extracting a plant of genus Melissa, family Labiatae (e.g. melissa) with hot water, polyhydric alcohol, etc., under refluxing and concentrating the extract after filtration and (B) preferably 0.01-5wt.% of one or more kinds of vitamins. The amount of the component B is preferably 1/10 of the extract. The vitamins compounded to the preparation are effective for remarkably promoting the activity of the melissa extract (activities to prevent and ameliorate chapped skin and prevent the sagging of skin and loss of skin luster to prevent the aging of skin) without causing side effects.

Description

[Detailed description of the invention]

0001

FIELD OF THE INVENTION The present invention relates to a skin preparation for external use, and more particularly to a skin preparation for external use that is highly effective in preventing and improving skin roughness, as well as preventing skin sagging and loss of luster, thereby preventing aging.

0002

[Prior Art] Conventionally, various raw materials extracted from natural products, such as proteins, polysaccharides, extracted extracts, natural polymers, etc., have been blended into external skin preparations because of their distinctive effects. However, the results were still insufficient and the effects were not as high as expected.

0003

[Problems to be Solved by the Invention] The present inventors have conducted extensive research to find a method for preventing skin roughness, improving skin roughness, preventing skin sagging, loss of luster, and increasing the effect of preventing aging. The present invention has been completed based on the discovery that this object can be achieved by blending a plant extract of the genus Melissa with one or more vitamins.

0004

[Means for Solving the Problems] That is, the present invention provides a skin preparation for external use, which is characterized in that it contains an extract of a plant belonging to the Lamiaceae family, the genus Melissa, and one or more vitamins. Hereinafter, the configuration of the present invention will be explained in detail. The plants of the genus Melissa of the Lamiaceae family used in the present invention include Melissa officinalis. These generally use leaves, but fruits and bark are also used. The extraction method for the plant extract of the Lamiaceae genus Melissa used in the present invention may be carried out according to a conventional method, and an example is as follows.

[0005] In the extraction method, a plant of the genus Melissa of the Lamiaceae family is heated under reflux in a solvent such as water, a polyhydric alcohol such as dipropylene glycol or 1,3-butylene glycol, or a mixture thereof, and then filtered. This extract is concentrated and used. Alternatively, an extract obtained by fractionating the extract obtained by the above-described method using adsorption chromatography such as silica gel chromatography can also be used.

[0006] In the present invention, when a plant of the genus Melissa of the Lamiaceae family is blended as an extract or as a fractionated extract, the blending amount is 0.0001 in the total amount of the skin external preparation.
-30% by weight, preferably 0.005-15% by weight. If it is less than 0.0001% by weight, the effect will not be exhibited, and if it exceeds 30% by weight, it is unfavorable in terms of the manufacturing process of the product.

[0007] The vitamins used in the present invention include vitamin A oil, retinol, retinol acetate, etc.
vitamin B2 such as riboflavin, riboflavin butyrate, flavin adenine dinucleotide, vitamin B6 such as pyridoxine hydrochloride, pyridoxine tripalmitate, pyridoxine dioctanoate, calcium bantothenate, D-pantothenyl alcohol, pantotenyl Pantothenic acids such as ethyl ether and acetyl pantothenyl ethyl ether, nicotinic acids such as inosit, ergocalciferol, cholecalciferol, nicotinic acid, nicotinamide, benzyl nicotinate, α-tocopherol, δ-tocopherol, DL-α acetate -tocopherol, DL-α-tocopherol nicotinic acid,
Vitamin E such as DL-α-tocopherol succinate.
Biotin etc.

[0008] There is no particular limitation on the amount of vitamins to be blended in the present invention, but preferably 0.
0.05 to 10% by weight, more preferably 0.01 to 5% by weight. The amount of vitamins to be added to the skin external preparation is 1/100 times or more, preferably 1/10 times or more by weight of the extract or extract of a plant belonging to the genus Melissa of the Lamiaceae family.

[0009] In addition to the above-mentioned essential ingredients, the external skin preparation of the present invention contains other ingredients normally used in external skin preparations such as cosmetics and pharmaceuticals, such as avocado oil, palm oil, peanut oil, beef tallow, rice bran oil, and jojoba. Oil, carnauba wax, lanolin, liquid paraffin, oxystearic acid, isostearyl palmitate, isostearyl alcohol and other oils, glycerin, sorbitol, polyethylene glycol, pyrrolidone carboxylic acid and its salts, collagen, hyaluronic acid and its salts, chondroitin sulfate and Humectants such as its salts, amyl paradimethylaminobenzoate,
Ultraviolet absorbers such as urocanic acid, ethyl diisopropyl cinnamate, sodium erythorbate, sage extract,
Antioxidants such as parahydroxyanisole, sodium stearyl sulfate, diethanolamine cetyl sulfate, cetyltrimethylammonium saccharin, polyethylene glycol isostearate, surfactants such as glyceryl arachiate, preservatives such as ethylbaraben, butylbaraben, auricularis, oren, Extracts of Chinese citrus, peony, Japanese japonica, birch, loquat, etc., anti-inflammatory agents such as glycyrrhizinic acid derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokitiol, zinc oxide, allantoin, placenta extract, glutathione, saxifrage extract, ascorbic acid derivatives, etc. whitening agent, carrot, aloe, mallow,
Extracts of iris, grape, lily, loofah, lily, etc., royal jelly, photosensor, cholesterol derivative,
Activators such as various amino acids, saffron, nebula, ginger, hypericum, ononis, rosemary,
Extracts such as garlic, blood circulation promoters such as γ-oryzanol and sodium dextran sulfate, antiseborrheic agents such as sulfur and thianthol, fragrances, water, alcohol, thickeners such as carboxyvinyl polymer, titanium yellow, cursamine,
A coloring agent such as safflower red may be appropriately blended as necessary.

[0010] The dosage form of the skin external preparation of the present invention is arbitrary;
Any dosage form may be used, such as a solution system, a solubilized system, an emulsification system, an undispersed powder system, a water-oil two-layer system, a water-oil-powder three-layer system, etc. In addition, the use of the skin external preparation of the present invention is arbitrary, and it can be used in facial cosmetics such as lotions, milky lotions, creams, and packs, makeup cosmetics such as foundations, lipsticks, and eye shadows, body cosmetics, aromatic cosmetics, and cleaning products. It can be used in creams, ointments, etc.

[0011]

[Examples] Next, Examples and Comparative Examples will be given to specifically clarify the present invention. The present invention is not limited thereby. The arrangement amount is weight %. Test Example 1 In the cream with the following formulation, 0 melissa extract* was added.
wt%, 5 wt%, 0 DL-α-tocopherol acetate
A skin roughness prevention and skin improvement effect test was conducted on a human body panel using creams with varying amounts of 0.5% and 0.5% by weight. That is, a skin replica of the skin surface morphology of a healthy female person (face) is taken using a replica method using myristic resin and observed under a microscope (17x magnification).

[0012] From the condition of the skin pattern and the peeling condition of the stratum corneum -
Thirty people (skin panel) who were judged to have a skin roughness rating of 1 or 2 based on the criteria shown in Example 1 were given the cream obtained in Example 1, a cream without Melissa extract, or acetic acid DL- on the left and right half of their faces. A cream containing no α-tocopherol was applied twice a day. Two weeks later, a replica was taken again and the condition of the skin was observed and evaluated according to the criteria in Table 1.

*Manufacturing method: Wash 100 g of Melissa leaves thoroughly with water, add 1.2 kg of 50% aqueous 1,3-butylene glycol solution and 2.4 ml of methyl paraoxybenzoate.
g and soaked at room temperature for 10 days. This extract is filtered to obtain a melissa extract. A. Setanol

0.5% Vaseline

2.0
Squalane

7.0 Self-emulsifying glyceryl monostearate
2.5 Polyoxyethylene sorbitan monostearate (20EO)


1.5 Pantothenyl ethyl ether
0.5 Jojoba oil

5.
0 Acetate-DL-α-tocopherol
0.5 or 0
B. Propylene glycol

5.0 Glycerin

5.0 Veegum (montmorillonite)
5.0 Melissa extract
5 or 0 potassium hydroxide

0.3 water


Residue - Manufacturing method - Heat A (oil phase) and B (aqueous phase) to 70°C to completely dissolve them. Add A to B and emulsify with an emulsifier. The emulsion was cooled using a heat exchanger to obtain cream.

[0014]

[Table-1]

[0015] The results are shown in Table 2.

[Table-2]

[0016] The results show that facial areas using cosmetics containing DL-α-tocopherol acetate and melissa or extract have a remarkable effect on preventing and improving rough skin compared to facial areas using other cosmetics. Admitted.

Example 1 Cream A. stearic acid

10.0% stearyl alcohol

4.0 Butyl stearate
8.0 Stearic acid monoglycerol ester
2.0 Vitamishi E
acetate
0.5
fragrance

0.4 Preservative

Appropriate amount B. Melissa extract
30.0
glycerin

4.0 Potassium hydroxide

0.4 Trisodium edetate
0.05
purified water

The remaining oil phase portion of A and water phase portion of B are each heated to 70°C to completely dissolve them. Add phase A to phase B,
Emulsify with an emulsifying machine. The emulsion was cooled using a heat exchanger to obtain cream.

Example 2 Cream A. Setanol

4.0% Vaseline

7.0 Isopropyl myristate
8.0
Squalane

15.0 Stearic acid monoglycerol ester
2.2 POE(20) Sorbitan Monostearate 2.8
Vitamin E Nicotinate

2.0 Fragrance

0.3 Antioxidant
Appropriate amount preservative

Appropriate amountB. glycerin

10.0 Melissa extract
0
．． 02 Dipropylene glycol

4.0 Sodium pyrrolidone carboxylate
1.0 Edetate disodium

0.01 Purified water

A cream was obtained according to the rest of Example 1.

Example 3 Emulsion A. Squalane

5.0% oleyl oleate

3.0 Vaseline

2
．． 0 Sorbitan sesquioleate
0.8
Polyoxyethylene oleyl ether (20E
O) 1.2 Vitamin A oil
0.
03 Fragrance

0.3 Preservative

Appropriate amountB. 1,3 butylene glycol
4
．． 5 Melissa extract

1.5 Sodium hyaluronate
0.5 ethanol

3.0
carboxyvinyl polymer
0.
2 Potassium hydroxide

0.1 Sodium hexametaphosphate
0.05 Purified water

A milky lotion was obtained according to the rest of Example 1.

Example 4 Foundation A. Setanol

3.5% deodorized lanolin

4.0 Jojoba oil

5.0
Vaseline

2.0 Squalane

6.0 Stearic acid monoglycerol ester
2.5 POE
(60) Hydrogenated castor oil
1.5 P
OE(20) Cetyl ether
1.0
Pyridoxine Tripalmitate
0.1
Preservative

Appropriate amount fragrance

0.3B. Propylene glycol
10.0
melissa extract

0.1 Mixed powder

12.0 Trisodium edetate
0.2
purified water

A foundation was obtained according to the rest of Example 1.

Example 5 Lotion A. ethanol

5.0% POE oleyl alcohol ether
2.0 2-ethylhexyl-P-dimethylaminobenzoate 0.18 Fragrance


0.05B. 1,3 butylene glycol

9.5 Sodium pyrrolidone carboxylate
0
．． 1 Melissa extract

5.0 Nicotinamide

0.3 Glycerin

5.0
purified water

The remaining alcohol phase of A was added to the aqueous phase of B and solubilized to obtain a lotion.

Example 6 Pack (1) Polyvinyl alcohol
10.0% (2
) Polyethylene glycol (molecular weight 400)
0.4(3) Glycerin

3.0 (4) Ethanol (9
5%)
8.0 (5) Melissa extract

0.1 (6) Inosit

0.1 (7) Preservative

0.1 (8)
fragrance

0.1 (9) Purified water

Mix and dissolve (4), (7), and (8) at room temperature, and add (1), (2), (3), and (5), (6), and (9) to 80%
After stirring and adding the mixture to the solution mixed and dissolved at ℃, the mixture was allowed to cool to room temperature to obtain a pack.

Example 7 Lipstick (1) Castor oil
2
0.0% (2) Cetyl alcohol
2
0.0 (3) Beeswax

5.0(4) Candelilla Row

30.0 (5) Melissa extract

2.0(6) Squalane

13.0(7) Carnauba Low

5.0(8) Pigment

5.0(9) Cholecalciferol
0.01 (10) Fragrance

Appropriate amount

0024
] (1) to (9) were mixed and dissolved at 80°C, poured into a mold, allowed to cool to room temperature, and then taken out from the mold to obtain a lipstick stick.

[0025]

[Effects of the Invention] The skin external preparation of the present invention has the effect of preventing rough skin and improving skin roughness, and the effect of preventing aging by preventing skin sagging and loss of luster, etc., of the extract of a plant belonging to the genus Melissa of the Lamiaceae family, by incorporating vitamins. It has the advantage of being able to increase significantly without side effects.

Claims (2)

[Claims] [Claim 1] A skin external preparation characterized by containing an extract of a plant of the genus Melissa of the Lamiaceae family and one or more vitamins. 2. The skin external preparation according to claim 1, wherein the plant of the genus Melissa of the Lamiaceae family is Melissa officinalis.