JPH04282311A - Aerosol-type foamable wound-disinfectant - Google Patents

Aerosol-type foamable wound-disinfectant

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Publication number
JPH04282311A
JPH04282311A JP3069205A JP6920591A JPH04282311A JP H04282311 A JPH04282311 A JP H04282311A JP 3069205 A JP3069205 A JP 3069205A JP 6920591 A JP6920591 A JP 6920591A JP H04282311 A JPH04282311 A JP H04282311A
Authority
JP
Japan
Prior art keywords
wound
disinfectant
aerosol
foam
collagen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP3069205A
Other languages
Japanese (ja)
Inventor
Ryuichi Endo
隆一 遠藤
Seigo Sato
佐藤 征吾
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koike Chemical Co Ltd
Original Assignee
Koike Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koike Chemical Co Ltd filed Critical Koike Chemical Co Ltd
Priority to JP3069205A priority Critical patent/JPH04282311A/en
Publication of JPH04282311A publication Critical patent/JPH04282311A/en
Pending legal-status Critical Current

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  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PURPOSE:To provide an aerosol-type foamable wound-disinfectant capable of surely disinfecting the wound to give easy feeling because the application of the disinfectant to the wound can be confirmed with eye and applicable without loss and the staining of clothes because the disinfectant is free from dripping tendency. CONSTITUTION:The objective disinfectant contains (a) a wound-disinfectant such as iodine, (b) an aqueous medium such as water or a waterethanol solution, (c) a foaming agent such as anionic and/or nonionic surfactant and (d) a conventional propellant for aerosol products as essential components and preferably further contains (e) a collagen compound such as collagen hydrochloride and/or (f) a film-forming agent such as a foamable agent containing a water-soluble polymer (e.g. polyvinyl alcohol). The components are filled in an aerosol container to obtain the aerosol-type foamable wound-disinfectant covering the wound with foam. The wound-disinfectant exhibits, in addition to the above effects, a hemostatic effect and a skin-regeneration effect when the disinfectant contains the component (e) and a wound-protecting effect to form a thin film on the wound when it contains the component (f).

Description

【発明の詳細な説明】[Detailed description of the invention]

【0001】0001

【産業上の利用分野】本発明は、傷口を泡状に覆うエア
ゾール型の発泡性傷口消毒剤に関する。
BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an aerosol-type foaming wound disinfectant that covers wounds in the form of foam.

【0002】0002

【従来の技術】家庭を中心として、簡易な傷口消毒剤が
使用されている。これは、消毒薬を水性液としたもので
、傷口に塗布あるいはポンプ容器で霧状に噴霧すること
により使用されている。
2. Description of the Related Art Simple wound disinfectants are used mainly at home. This is an aqueous disinfectant that is applied to the wound or sprayed into a mist using a pump.

【0003】しかしこの傷口消毒剤は、液体であるので
、塗布したあとに垂れ落ちて効果が持続しなかったり、
衣服等を汚す場合がある。また、流れ落ちてしまう事お
よび透明である事から、傷口にしっかりと塗布され効果
が発揮されているかを使用者が確認できずに不安となる
ケースが多く、必要以上に多く塗布したり、不安感を拭
いきれない場合がある。また、真皮が露出したり、血が
滲み出ている状態が目で見える場合は、誰でも不安感に
かられるものであり、気持ちのよいものではない。
[0003] However, since this wound disinfectant is a liquid, it may drip down after application and the effect may not last long.
May stain clothes, etc. In addition, because it runs off and is transparent, there are many cases where users become anxious because they cannot confirm whether it has been applied properly to the wound and is effective, and they may end up applying more than necessary or feeling anxious. It may not be possible to wipe it completely. Furthermore, when the dermis is exposed or blood is visibly seeping out, anyone feels anxious and it is not a pleasant experience.

【0004】0004

【発明が解決しようとする課題】本発明は、消毒剤が傷
口に間違いなく適用された事が一目で判り、しかも、効
果および安心感が大きい傷口消毒剤を提供するものであ
る。
SUMMARY OF THE INVENTION It is an object of the present invention to provide a wound disinfectant that can be seen at a glance that the disinfectant has been applied to the wound without fail, and that is highly effective and provides a sense of security.

【0005】[0005]

【課題を解決するための手段】本発明のエアゾール型発
泡性傷口消毒剤は、傷口消毒薬、水性媒体、発泡剤およ
び噴射剤を含有する泡形成性薬剤を、エアゾール容器に
充填したことを特徴とする。
[Means for Solving the Problems] The aerosol-type foaming wound disinfectant of the present invention is characterized in that an aerosol container is filled with a foam-forming agent containing a wound disinfectant, an aqueous medium, a foaming agent, and a propellant. shall be.

【0006】[0006]

【作用】エアゾール容器から傷口消毒剤が患部(傷口)
に噴出されると、発泡して泡を形成し傷口全体を覆う。 この泡はしばらくの間持続し、やがて、あるいはガーゼ
等で押さえることにより消泡する。
[Action] The wound disinfectant is applied to the affected area (wound) from the aerosol container.
When squirted, it foams to form bubbles that cover the entire wound. This foam lasts for a while, and eventually disappears by pressing with gauze or the like.

【0007】[0007]

【実施例】図1は、本発明のエアゾール型発泡性傷口消
毒剤の実施例を示す断面図であり、エアゾール容器11
内に、泡形成性薬剤21が充填されている。13はディ
ップチューブを示す。
[Example] Fig. 1 is a sectional view showing an example of the aerosol type foaming wound disinfectant of the present invention.
A foam-forming agent 21 is filled inside. 13 indicates a dip tube.

【0008】泡形成性薬剤21は、傷口消毒薬、水性媒
体、発泡剤および噴射剤を含む。アクチュエータ17を
押してバルブ15を開口すると、噴出口19より泡形成
性薬剤21が取り出される。このとき、噴出時の衝撃(
撹拌)、噴射剤のガス化により、発泡剤を含む水性媒体
が発泡し、泡形成性薬剤21は細かい白い泡の塊りとな
って手足等の傷口の上を覆う。そこで、薬剤21が確実
に傷口に適用されたことが確認できる。また、白い泡で
傷口が覆われて見えなくなるので安心感が生じる。さら
に、通常の液剤と違って液垂れがないので、無駄がなく
、衣服等を汚すことがない。
Foam-forming agents 21 include wound disinfectants, aqueous media, foaming agents, and propellants. When the actuator 17 is pushed to open the valve 15, the foam-forming agent 21 is taken out from the spout 19. At this time, the shock at the time of ejection (
By stirring) and gasifying the propellant, the aqueous medium containing the foaming agent foams, and the foam-forming agent 21 turns into a mass of fine white foam and covers the wound on the limb or the like. Therefore, it can be confirmed that the medicine 21 has been reliably applied to the wound. In addition, the wound is covered with white foam and becomes invisible, giving a sense of security. Furthermore, unlike ordinary liquids, there is no dripping, so there is no waste and there is no chance of staining clothes, etc.

【0009】消泡ないし破泡することにより、傷口消毒
薬が傷口に適用され、消毒効果が得られる。泡が自然に
消泡するまでそのまま放置してもよく、また、ガーゼ等
を上から軽く押し当てて破泡し、余剰の成分をガーゼ等
に吸収して絆創膏で上からそのまま固定してもよい。
[0009] By defoaming or breaking the foam, the wound disinfectant can be applied to the wound and a disinfecting effect can be obtained. You can leave it as is until the foam naturally disappears, or you can break the foam by lightly pressing gauze, etc. from above, absorb the excess ingredients into gauze, etc., and fix it with a bandage from above. .

【0010】泡の細かさ、泡の維持時間は、発泡剤の種
類や量で調整でき、また、必要に応じて泡形成性薬剤中
に増粘剤(増泡剤)を添加することもできる。さらに、
泡形成性薬剤中にコラーゲン類や被膜形成剤を添加する
こともできる。
[0010] The fineness of the foam and the foam maintenance time can be adjusted by the type and amount of the foaming agent, and if necessary, a thickener (foaming agent) can be added to the foam-forming agent. . moreover,
Collagens and film-forming agents can also be added to the foam-forming agent.

【0011】組成中にコラーゲン類を含む場合は、上記
処置により、止血ならびに皮膚再生効果を促すことがで
きる。また、組成中に皮膜形成剤を含む場合は、消泡後
、傷口上に薄い被膜が形成されて傷口を保護する。
[0011] When collagens are included in the composition, the above treatment can promote hemostasis and skin regeneration effects. Furthermore, when a film forming agent is included in the composition, a thin film is formed on the wound after defoaming to protect the wound.

【0012】傷口消毒剤としては、ヨード、ポンピドン
ヨード、アクリノール、アクリノフラビン、ニトロフラ
ゾン、塩化ベンザルコニウム、塩化ベンゼトニウム、ク
ロルヘキシジンなどが用いられる。
[0012] As the wound disinfectant, iodine, pompidone iodine, acrinol, acrinoflavin, nitrofurazone, benzalkonium chloride, benzethonium chloride, chlorhexidine, etc. are used.

【0013】コラーゲン類のコラーゲン塩酸塩は、血液
に接触すると水分吸収し、血小板粘着、凝集を起こす。 また、コラーゲンの−COOH基をエステル化した正電
荷リッチコラーゲンは、未修飾の元のコラーゲンより強
い血小板粘着を起こし、通常の消毒剤より止血効果が期
待できる。さらに、コラーゲン繊維の添加により、酸性
下でコラーゲン繊維が水を吸って膨潤し、粘着性が増し
、原液特性の変化により創傷部への付着性と皮膚成形性
が改善される。
Collagen hydrochloride, which is a type of collagen, absorbs water when it comes into contact with blood, causing platelet adhesion and aggregation. In addition, positively charged rich collagen obtained by esterifying the -COOH group of collagen causes stronger platelet adhesion than the original unmodified collagen, and is expected to have a more hemostatic effect than ordinary disinfectants. Furthermore, by adding collagen fibers, the collagen fibers absorb water and swell under acidic conditions, increasing adhesiveness and improving adhesion to wound areas and skin moldability due to changes in the properties of the stock solution.

【0014】コラーゲン類は、原液(泡形成性薬剤から
噴射剤を除いた組成)中に0.1〜3.0重量%配合す
ることが望ましい。水性媒体としては、水あるいは水−
エタノール溶液のような人体に安全なものが用いられる
[0014] Collagen is desirably blended in an amount of 0.1 to 3.0% by weight in the stock solution (composition obtained by removing the propellant from the foam-forming agent). The aqueous medium is water or water-
A substance that is safe for the human body, such as an ethanol solution, is used.

【0015】発泡剤としては、界面活性剤が代表的であ
り、アニオン界面活性剤、ノニオン界面活性剤などが用
いられる。ノニオン界面活性剤を用いる場合は、傷口消
毒薬剤の他の成分の可溶化のために、新油性の高いノニ
オン界面活性剤(例えば、HLB=2〜3)と、親水性
の高い界面活性剤(例えば、HLB=10〜12)とを
適当な割合で併用することができる。前者の具体例とし
ては、ソルビタンの高級脂肪酸エステル(スパン20、
花王アトラス社製など)、後者の具体例としては、ソル
ビタン部分高級脂肪酸エステルのエチレンオキシド付加
物(トゥイーン20、花王アトラス社製など)が挙げら
れる。また、ポリオキシエチレン高級アルキルエーテル
等のエチレンオキシド付加モル数を調整することによっ
ても、HLBをコントロールできる。
[0015] As the foaming agent, surfactants are typical, and anionic surfactants, nonionic surfactants, etc. are used. When using a nonionic surfactant, in order to solubilize other components of the wound disinfectant, a highly oily nonionic surfactant (for example, HLB = 2 to 3) and a highly hydrophilic surfactant ( For example, HLB=10-12) can be used in combination at an appropriate ratio. Specific examples of the former include higher fatty acid esters of sorbitan (span 20,
Specific examples of the latter include ethylene oxide adducts of sorbitan partial higher fatty acid esters (Tween 20, manufactured by Kao Atlas, etc.). Furthermore, HLB can also be controlled by adjusting the number of moles of ethylene oxide added to polyoxyethylene higher alkyl ether or the like.

【0016】増粘剤としては、カルボキシメチルセルロ
ース、カルボキシビニルポリマーなどが用いられる。
[0016] As the thickener, carboxymethylcellulose, carboxyvinyl polymer, etc. are used.

【0017】被膜形成剤としては、ポリビニルアルコー
ル、ポリ酢酸ビニル、ポリ酢酸ビニル部分加水分解物、
ポリビニルピロリドン、あるいはビニルピロリドン−酢
酸ビニル共重合体などの水溶性高分子が主に用いられる
。また、これらは増粘剤としても働き、逆に上記増粘剤
は被膜形成剤として作用するものもある。被膜形成剤は
、原液中に3〜20重量%配合することが好ましい。
Film forming agents include polyvinyl alcohol, polyvinyl acetate, polyvinyl acetate partial hydrolyzate,
Water-soluble polymers such as polyvinylpyrrolidone or vinylpyrrolidone-vinyl acetate copolymer are mainly used. These also act as thickeners, and some of the above thickeners act as film-forming agents. The film-forming agent is preferably blended in an amount of 3 to 20% by weight in the stock solution.

【0018】噴射剤としては、エアゾール製品に使用さ
れているものが一般に用いられ、ジメチルエーテル、液
化石油ガス、フロン、炭酸ガスなどが用いられる。噴射
剤5〜25重量部と原液75〜95重量部を混合して、
エアゾール容器中に充填するのが一般的である。
As the propellant, those used in aerosol products are generally used, such as dimethyl ether, liquefied petroleum gas, chlorofluorocarbons, carbon dioxide gas, and the like. Mixing 5 to 25 parts by weight of propellant and 75 to 95 parts by weight of stock solution,
It is generally filled into an aerosol container.

【0019】下記表1処方の原液85重量部と噴射剤(
ジメチルエーテル、LPガスの混合物)15重量部とを
エアゾール容器に充填して本発明の傷口消毒剤を作成し
た。 なお、ヨウ度丁幾はヨードの8%エタノール溶液である
85 parts by weight of the stock solution of the formulation in Table 1 below and a propellant (
A wound disinfectant of the present invention was prepared by filling an aerosol container with 15 parts by weight of a mixture of dimethyl ether and LP gas. Note that the iodine content is an 8% ethanol solution of iodine.

【0020】[0020]

【表1】        ヨウ度丁幾                
                         
     10  wt%    ポリビニルピロリド
ン                        
            15  wt%    ポリ
オキシエチレン(9モル)ラウリルエーテル     
          0.5wt%    ポリオキシ
エチレン(15モル)ラウリルエーテル       
        1.0wt%    エタノール  
                         
                   12  wt
%    コラーゲン               
                         
       1.5wt%    精製水     
                         
                    バランス 
                         
                         
          100  wt%
[Table 1] Iodity degree

10 wt% polyvinylpyrrolidone
15 wt% polyoxyethylene (9 mol) lauryl ether
0.5wt% polyoxyethylene (15 mol) lauryl ether
1.0wt% ethanol

12wt
% collagen

1.5wt% purified water

balance


100 wt%

【0021】こ
の傷口消毒剤を傷口に噴出したところ、わずかに着色し
た細かい白い泡が傷口表面を覆った。
When this wound disinfectant was squirted onto the wound, fine, slightly colored white bubbles covered the surface of the wound.

【0022】[0022]

【発明の効果】本発明によれば、傷口消毒薬を発泡性組
成物としてエアゾール容器に充填することにより、消毒
剤が傷口を覆うことが目で確認でき、消毒が確実に行な
え安心感が高い。また、通常の液剤のように、液垂れで
衣服を汚すこともない。
[Effects of the Invention] According to the present invention, by filling an aerosol container with a wound disinfectant as a foaming composition, it is possible to visually confirm that the disinfectant covers the wound, ensuring disinfection and providing a high sense of security. . Also, unlike regular liquids, it does not drip and stain clothes.

【0023】また、コラーゲン類を含有するときは、そ
の止血作用および皮膚再生作用を利用することができる
[0023] Furthermore, when collagens are contained, their hemostatic and skin regenerating effects can be utilized.

【図面の簡単な説明】[Brief explanation of the drawing]

【図1】図1は、本発明のエアゾール型発泡性傷口消毒
剤の実施例を示す断面図である。
FIG. 1 is a sectional view showing an embodiment of the aerosol-type foaming wound disinfectant of the present invention.

【符号の説明】[Explanation of symbols]

11  エアゾール容器 13  ディップチューブ 15  バルブ 17  アクチュエータ 19  噴出口 21  泡形成性薬剤 11 Aerosol container 13 Dip tube 15 Valve 17 Actuator 19 Spout 21 Foam-forming agents

Claims (3)

【特許請求の範囲】[Claims] 【請求項1】  傷口消毒薬、水性媒体、発泡剤および
噴射剤を含有する泡形成性薬剤を、エアゾール容器に充
填したことを特徴とするエアゾール型発泡性傷口消毒剤
1. An aerosol-type foaming wound disinfectant, characterized in that an aerosol container is filled with a foam-forming agent containing a wound disinfectant, an aqueous medium, a foaming agent, and a propellant.
【請求項2】  泡形成性薬剤が、コラーゲン類をさら
に含む請求項1に記載のエアゾール型発泡性傷口消毒剤
2. The aerosol-type foaming wound disinfectant according to claim 1, wherein the foam-forming agent further contains collagen.
【請求項3】  泡形成性薬剤が、被膜形成剤をさらに
含む請求項1または2に記載のエアゾール型発泡性傷口
消毒剤。
3. The aerosol-type foaming wound disinfectant according to claim 1, wherein the foam-forming agent further comprises a film-forming agent.
JP3069205A 1991-03-08 1991-03-08 Aerosol-type foamable wound-disinfectant Pending JPH04282311A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP3069205A JPH04282311A (en) 1991-03-08 1991-03-08 Aerosol-type foamable wound-disinfectant

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3069205A JPH04282311A (en) 1991-03-08 1991-03-08 Aerosol-type foamable wound-disinfectant

Publications (1)

Publication Number Publication Date
JPH04282311A true JPH04282311A (en) 1992-10-07

Family

ID=13395991

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3069205A Pending JPH04282311A (en) 1991-03-08 1991-03-08 Aerosol-type foamable wound-disinfectant

Country Status (1)

Country Link
JP (1) JPH04282311A (en)

Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07196530A (en) * 1993-11-24 1995-08-01 Aspid Sa De Cv Polymerized collagen-based antifibrous composition
JPH0899873A (en) * 1994-09-30 1996-04-16 Kobayashi Pharmaceut Co Ltd Aerosol type foamable cleaning disinfectant for wound
WO1996017595A1 (en) * 1994-12-06 1996-06-13 Giltech Limited Foamable formulation and foam
JP2005015365A (en) * 2003-06-25 2005-01-20 Koike Kagaku Kk Aerosol type cleansing disinfectant
JP2006505583A (en) * 2002-10-25 2006-02-16 フォーミックス エルティーディー. Cosmetic and pharmaceutical foam
JP2007503428A (en) * 2003-08-25 2007-02-22 フォーミックス エルティーディー. Osmotic pharmaceutical foaming agent
WO2007094245A1 (en) * 2006-02-16 2007-08-23 Ricoh Company, Ltd. Fixer, fixing device, and image forming apparatus
JP2009104205A (en) * 2009-02-16 2009-05-14 Ricoh Co Ltd Fixing method and image forming method
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US10092588B2 (en) 2009-07-29 2018-10-09 Foamix Pharmaceuticals Ltd. Foamable compositions, breakable foams and their uses
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US10398641B2 (en) 2016-09-08 2019-09-03 Foamix Pharmaceuticals Ltd. Compositions and methods for treating rosacea and acne
US11135315B2 (en) 2010-11-30 2021-10-05 Convatec Technologies Inc. Composition for detecting biofilms on viable tissues

Cited By (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07196530A (en) * 1993-11-24 1995-08-01 Aspid Sa De Cv Polymerized collagen-based antifibrous composition
JPH0899873A (en) * 1994-09-30 1996-04-16 Kobayashi Pharmaceut Co Ltd Aerosol type foamable cleaning disinfectant for wound
US6187290B1 (en) 1994-12-06 2001-02-13 Giltech Limited Physiologically acceptable foamable formulation and foam
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