JPH0347268A - Fluid treatment apparatus and method for driving the same - Google Patents

Abstract

PURPOSE:To reduce the necessary installation area of a system by generating pressure change in the fluid within a liquid inflow space part and/or liquid outflow space part by the reciprocating movement of a flexible member to allow the fluid to pass through a fluid treatment part. CONSTITUTION:When gas or a liquid is introduced into an operating chamber 8 from a pressure controller 10 through a fluid pressure supply port 7c, a flexible member 6 is reciprocally moved by the fluid pressure and the pressure change of the blood in a fluid inflow space part 4 is generated by the reciprocating movement of the flexible member 6. Therefore, by the pressure change and the action of two check valves 9, 13, the blood introduced from a blood introducing port 7a smoothly flows through a hollow fiber bundle 3 from the fluid inflow space part 4 to a fluid outflow space part 5 as shown by an arrow and gas exchange is performed between said blood and the oxygen-containing gas introduced from a gas introducing port 14 on the way. By this method, the installation area of the system can be reduced.

Description

Detailed Description of the Invention [Industrial Application Field] The present invention relates to a fluid processing device such as an artificial lung or an artificial dialysis machine, and particularly to a fluid processing device configured to allow fluid to pass through a fluid processing section using a pump and its drive. Regarding the method.

[Prior Art] Conventionally, in a fluid processing device such as a hollow fiber oxygenator used for gas exchange between carbon dioxide and oxygen in blood, a roller pump has been used as a pump for blood circulation. ing. This pump was provided separately from the main body of the oxygenator.

[Problem to be solved by the invention] However, when using this conventional hollow fiber in an oxygenator,
In use, it is necessary to assemble the system by connecting the oxygenator body and the roller pump with piping, tubes, etc., which is not only time-consuming and troublesome, but also increases the area required for the system to be set up. there were. Further, when a roller pump is used, there is a problem that cracks occur in the tube due to long-term straining of the tube, resulting in blood leakage, contamination, and the like. Furthermore, blood tends to stagnate in the blood inflow space or the blood outflow space, and this stagnation can lead to thrombus formation, especially during extracorporeal circulation without the use of anticoagulants. There was a risk of causing thread blockage.

In addition, E CM O (Extracorporal
Membraeee Oxygenation),
V-A bypass and V-V bypass are used in most cases, but when a roller pump is used, it buffers excessive suction caused by forced blood removal by the roller pump, and prevents the blood removal catheter from sticking to the blood vessel wall. To prevent this, venous reservoirs or positive pressure absorption chambers are provided. However, in extracorporeal circulation without the use of anticoagulants, stagnation within the 5 circuits causes thrombus formation, so there is a problem in that these venous reservoirs or positive pressure absorption chambers cannot be provided.

The present invention has been made in view of the above-mentioned problems, and its objects are to reduce the area required for installing the system, to facilitate its assembly, and to prevent the occurrence of fluid stagnation. It is an object of the present invention to provide a fluid processing device and a method for driving the same that can prevent various adverse effects caused by these.

[Means for Solving the Problems] In order to solve the above problems, the present invention provides a fluid processing section having a fluid inlet and a fluid outlet, and a fluid processing section provided respectively corresponding to the fluid inlet and the fluid outlet. In the fluid treatment device, the fluid treatment device includes a pair of fluid inflow space and a fluid outflow space, each having a fluid inlet and a fluid inlet, the fluid inlet can be made conductive or shut off, respectively, and the fluid flow is directed to the fluid inlet space. a pair of through-hole opening/closing means for preventing backflow directed from the fluid inflow space to the fluid outflow space; The flexible member includes a flexible member, a working chamber provided outside the flexible member, and a fluid pressure applying means for applying fluid pressure to reciprocate the flexible member within the working chamber, The present invention proposes a fluid treatment device characterized in that the reciprocating movement of members causes pressure fluctuations in the fluid in the fluid inflow space and/or the fluid outflow space to cause the fluid to pass through the fluid treatment section. It is.

In the above structure, a structure is proposed in which the fluid processing section includes a hollow system bundle.

In the above structure, a structure in which the communication port opening/closing means is a check valve is also proposed.

Further, in the above configuration, the present invention provides a first opening/closing means that allows the communication port opening/closing means to conduct or shut off the fluid communication port of the fluid inflow space, and the fluid communication port of the fluid outflow space. The second
The fluid pressure applying means includes a first pressure source that applies negative fluid pressure in the working chamber, a second pressure source that applies negative fluid pressure or atmospheric pressure, and the first pressure source. A first pressure applying flow path that communicates between the pressure source and the working chamber, and a second pressure applying flow path that communicates the second pressure source and the working chamber, and both flow paths can be communicated or blocked, respectively. The present invention proposes a fluid treatment device characterized by a configuration including a switching means capable of switching between the two.

Furthermore, in the fluid treatment apparatus according to the above configuration, the present invention includes a first step of bringing the first opening/closing means into a closed state, and, after the first step, bringing the second opening/closing means into an open state. , the switching means on the fluid inflow space side is connected to the first switching means.
a second step of switching to the pressure applying flow path;
a third step of bringing the opening/closing means into a closed state; a fourth step of opening the first opening/closing means after the third step; and a fourth step after the third step and the fourth step. The method further comprises a fifth step of switching the switching means to the second pressure applying channel, and a control means for driving the communication port opening/closing means and the fluid pressure applying means by sequentially repeating each step. This paper proposes a fluid treatment device.

In this configuration, the control means causes the switching means to switch between the two flow paths after the second step, before the third step, after the fifth step, and before the first step. It is proposed that each further comprises a step of blocking both of them.

Further, in the fluid treatment apparatus according to the present invention, the switching means includes a first switching means on the fluid inflow space side and a second switching means on the fluid outflow space side; a first step of closing the first opening/closing means, switching the second switching means to the second pressure applying flow path, and switching the first switching means to the first pressure applying flow path; a second step, and a third step of opening the second opening/closing means and switching the second switching means to the first pressure applying channel; and bringing the second opening/closing means into a closed state. a fifth step of opening the first opening/closing means; and a sixth step of switching the first switching means to the second pressure applying channel. The present invention proposes a fluid treatment device comprising a control means for driving the communication port opening/closing means and the fluid pressure applying means by sequentially repeating each step.

In this configuration, after the second step and before the third step, the step of blocking both the flow paths by the first switching means, and the step of blocking both the flow paths by the second switching means. further comprising the step of blocking either of the flow paths, and further comprising the step of blocking both of the flow paths by the second switching means after the third step and before the fourth step. There is proposed a fourth method comprising the step of blocking both of the flow paths by the first switching means after the sixth step and before the first step.

Furthermore, in the fluid treatment device according to the above configuration, the switching means includes a first switching means on the fluid inflow space side and a second switching means on the fluid outflow space side, and a first step of bringing the first opening/closing means into a closed state; and opening the second opening/closing means, placing the first switching means in the first pressure applying flow path and connecting the second switching means to the first pressure applying channel; a second step of respectively switching to the first pressure applying channel; a third step of bringing the second opening/closing means into a closed state; and a fourth step of bringing the first opening/closing means into an open state. , a fifth step of switching the first switching means to the second pressure applying flow path, and a sixth step of switching the second switching means to the second pressure applying flow path, each of which includes: The present invention proposes a fluid treatment device comprising a control means for driving the communication port opening/closing means and the fluid pressure applying means by sequentially repeating the steps.

In this configuration, after the second step and before the third step, the step of blocking both the flow paths by the first switching means, and the step of blocking both the flow paths by the second switching means. further comprising the step of blocking either of the flow paths, after the sixth step and before the first step, blocking both of the flow paths by the first switching means; A device further comprising the step of blocking both of the flow paths by a second switching means is proposed.

The present invention also provides a fluid treatment device having a fluid inlet and a fluid outlet, a pair of fluid inlet spaces and a fluid outlet, each provided corresponding to the fluid inlet and the fluid outlet, and each having a fluid communication port. a pair of backflow-preventing communication ports that enable each of the fluid communication ports to conduct or shut off, and direct the flow of fluid from the fluid inflow space to the fluid outflow space; a deformable flexible member provided on the wall means that partitions the fluid inflow space, a working chamber provided outside the flexible member, and a flexible member disposed within the working chamber. a first opening/closing means for applying fluid pressure to reciprocate the fluid inlet, the inlet opening/closing means being able to conduct or shut off the fluid inlet of the fluid inflow space; a second opening/closing means that can connect or shut off the fluid communication port of the space, and the fluid pressure applying means is connected to a first pressure source that applies negative fluid pressure in the working chamber and a second pressure source that applies atmospheric pressure; a first pressure applying channel that communicates the first pressure source and the working chamber; and a second pressure source that communicates the second pressure source and the working chamber. A first pressure applying channel capable of communicating or blocking the pressure applying channel and the first pressure applying channel.
a first step of bringing the first opening/closing means into a closed state; a second step of setting the second connecting means in a cutoff state after the first step; a third step of setting the second opening/closing means in an open state after the second step; After the step, a fourth step of bringing the first passage means into a communicating state, and substantially simultaneously after the fourth step, bringing the second opening/closing means into a closed state and opening the first passage means. a fifth means for placing the disconnection means in a disconnection state and placing the second passage means in a communication state;
and a sixth step of opening the first opening/closing means after the fifth step, thereby driving the communication port opening/closing means and the fluid pressure applying means; The present invention proposes a fluid treatment device characterized in that the reciprocating movement of the flexible member causes pressure fluctuations in the fluid in the fluid inflow space and allows the fluid to pass into the fluid treatment section.

Furthermore, in the present invention, in the fluid treatment apparatus according to the above configuration, there is provided a driving method for causing fluid to pass through the fluid treatment section, the first opening/closing means being in a closed state.
After the first step, a second step of opening the second opening/closing means and switching the switching means on the fluid inflow space side to the second pressure applying channel; a third step of bringing the second opening/closing means into a closed state; a fourth step after the third step of bringing the first opening/closing means into an open state; The present invention proposes a method for driving a fluid processing device, comprising a fifth step of switching the switching means to the second pressure applying channel after step 4, and repeating each step in sequence. It is.

In this method, after the second step, before the third step, after the fifth step, and before the first step, both of the flow paths are shut off by the switching means. A driving method is proposed, each further comprising steps.

Further, in the present invention, in the fluid treatment apparatus according to the above configuration, the switching means is a first switch on the fluid inflow space side.
and a second switching means on the side of the fluid outflow space, the driving method for passing fluid into the fluid processing section, wherein a first step of bringing the first opening/closing means into a closed state. a second step of switching the second switching means to the second pressure applying flow path and switching the first switching means to the first pressure applying flow path; and a second step of switching the second switching means to the first pressure applying flow path; a third step of switching the second switching means to the first pressure applying channel; a fourth step of switching the second switching means to the closed state; and a fourth step of switching the second switching means to the first pressure applying channel; and a sixth step of switching the first switching means to the second pressure applying flow path, and each step is performed by sequentially repeating the steps. This paper proposes a method.

In this method, after the second step and before the third step, the first switching means blocks both of the flow paths; The method further comprises a step of blocking both flow paths, and after the third step and before the fourth step, blocking both of the flow paths by the second switching means. A driving method is proposed, further comprising the step of blocking both of the flow paths by the first switching means after the sixth step and before the first step.

Further, in the present invention, in the fluid treatment device according to the above configuration, the switching means is a first switch on the fluid inflow space side.
and a second switching means on the side of the fluid outflow space, the driving method for passing fluid into the fluid processing section, wherein a first step of bringing the first opening/closing means into a closed state. and a second opening/closing means that opens the second opening/closing means and switches the first switching means to the first pressure applying flow path and the second switching means to the first pressure applying flow path. a third step of opening the second opening/closing means; a fourth step of opening the first opening/closing means; and a fourth step of opening the first switching means. A driving method comprising: a fifth step of switching to the pressure applying flow path; and a sixth step of switching the second switching means to the second pressure applying flow path, and each step is performed by sequentially repeating each step. This is what we propose.

In this method, after the second step and before the third step, the step of blocking both the flow paths by the first switching means; further comprising the step of blocking both flow paths, and after the sixth step and before the first step, blocking both of the flow paths by the first switching means. A method is proposed, further comprising: blocking both of the flow paths by the second switching means.

Further, in the present invention, there is provided a fluid processing section having a fluid inlet and a fluid outlet, a pair of fluid inlet spaces provided corresponding to the fluid inlet and the fluid outlet, and each having a fluid communication port; a fluid treatment device comprising a fluid outflow space, a pair of backflow prevention conductors that enable the fluid communication ports to be connected or shut off, respectively, and direct the flow of fluid from the fluid inflow space to the fluid outflow space; a mouth opening/closing means, a deformable flexible member provided on the wall means that partitions the fluid inflow space, and an operating chamber provided outside the flexible member;
a fluid pressure applying means for applying a fluid pressure to reciprocate the flexible member within the working chamber, and the fluid passage opening/closing means can enable the fluid passage opening of the fluid inflow space to conduct or shut off. a first opening/closing means and a second opening/closing means capable of making the fluid communication port of the fluid outflow space conductive or disconnected; a second pressure source that applies negative fluid pressure or atmospheric pressure; a first pressure applying channel that communicates the first pressure source and the working chamber; and the second pressure source. A second pressure-applying channel that communicates with the working chamber, and a first communication means that can communicate or cut off the first pressure-applying channel, and a second pressure-applying channel that communicates or disconnects the second pressure-applying channel. In a fluid processing device comprising a second passage means that can be shut off, a driving method for passing a fluid into the fluid processing section, the method comprising: a first step of bringing the first opening/closing means into a closed state; After the first step, a second step of turning the second passage means into a closed state; and after the second step, a third step of turning the second opening/closing means into an open state.
a fourth step of bringing the first passage means into a communicating state after the third step, and substantially simultaneously bringing the second opening/closing means into a closed state after the fourth step. , the first guard means is turned off, and the second guard is turned off.
a fifth step of bringing the passage means into a communicating state;
The present invention proposes a method for driving a fluid processing device, characterized in that after the step, a sixth step of opening the first opening/closing means is repeated in sequence.

[Function 1] In the fluid treatment device of the present invention having the above configuration, when fluid pressure is applied within the working chamber by the fluid pressure applying means, the flexible member reciprocates; A pressure fluctuation is generated in the fluid in the fluid inflow space and/or the fluid outflow space, and due to the action of this pressure fluctuation and the communication port opening/closing means, the fluid introduced from the fluid communication port passes through the fluid inlet and is processed. The fluid passes through the fluid outlet and is further sent out through the fluid inlet. In other words, the fluid flows smoothly from the fluid passage port on the fluid inflow space side, through the fluid processing section, and to the fluid communication port on the fluid outflow space side, and as a result, the fluid flows inside the fluid inflow space and the fluid outflow space. Eliminates fluid stagnation.

In addition, when used as an artificial lung, controlling the pressure in the working chamber allows for gentler blood removal, eliminating the need for a venous reservoir or positive pressure prevention chamber in the extracorporeal circulation circuit. Additional retention portions may be provided in the entire extracorporeal circuit.

Furthermore, by allowing blood to flow from the top to the bottom of the oxygenator,
If a flexible member is provided in the blood inflow space and the blood is caused to flow into the inflow part by a drop, the blood will always flow as if being pushed out, so that no positive pressure will be generated in the blood within the device.

Further, the communication port opening/closing means includes a first opening/closing means and a second opening/closing means, and the fluid pressure applying means switches the first pressure applying flow path and the second pressure applying flow path so as to be able to communicate with or disconnect from each other. By providing the switching means to obtain the fluid flow, the fluid flows more smoothly from the fluid inlet of the fluid inflow space to the fluid inlet of the fluid outflow space, and the fluid is effectively retained in the fluid inflow space and the fluid outflow space. It can be prevented.

In addition, in the above-mentioned method for driving a fluid processing device, by switching the switching means to the first pressure applying flow path, the working chamber becomes a positive pressure state, and therefore the flexible member becomes a pressed state, and conversely, the switching means is switched to a positive pressure state. By switching to the second pressure-applying flow path, the working chamber becomes in a positive pressure or atmospheric pressure state, and therefore the flexible member becomes in a suction state. and a second step of opening the second opening/closing means on the outflow side and switching the switching means on the inflow side to the first pressure applying channel after the first step, the fluid inflow space is closed. a third step in which the fluid in the part passes through the fluid processing part, is forced into the fluid outflow space, is led out from the fluid communication port, and closes the second opening/closing means; A fourth step of opening the first opening/closing means, and a fifth step of switching the switching means to the second pressure applying channel after the third and fourth steps, the fluid is injected into the fluid inflow space. Fluid is introduced through the communication port.

In another method, the first step of bringing the first opening/closing means into a closed state, switching the second switching means to the second pressure applying flow path, and switching the first switching means to the first pressure applying flow path, In the second step, the fluid in the fluid inflow space passes through the fluid treatment part and is forced into the fluid outflow space, thereby opening the second opening/closing means and switching the second switching means to the first. The third step of switching to the pressure applying channel causes the fluid in the fluid outflow space to be led out from the blood communication port, and the fourth step of switching the second opening/closing means to the closed state and opening the first opening/closing means. By the fifth step of setting the state, and the sixth step of switching the first switching means to the second pressure applying flow path,
Fluid is introduced into the fluid inflow space from the fluid communication port.

Still another method includes the first step of bringing the first opening/closing means into the closed state, and the step of bringing the second opening/closing means into the open state;
and a second step of switching the switching means to the first pressure applying flow path and the second switching means to the first pressure applying flow path, the fluid in the fluid outflow space is led out from the fluid communication port, A third step in which the fluid in the fluid inflow space passes through the fluid treatment section and is pushed into the fluid outflow space, and the second opening/closing means is brought into a closed state; and a fourth step in which the first opening/closing means is brought into an open state. , a fifth step of switching the first switching means to the second pressure applying flow path, and a sixth step of switching the second switching means to the second pressure applying flow path,
Fluid is introduced into the fluid inflow space from the fluid communication port, and the fluid in the fluid inflow space passes through the fluid treatment section and is forced into the fluid inflow space.

In each of the above methods, by sequentially repeating each step and b, the fluid flows more smoothly from the fluid inlet of the fluid inflow space to the fluid outflow space, and the fluid inflow space and the fluid outflow space are It is possible to effectively prevent fluid from stagnation in the area.

Furthermore, each of the above methods includes a step of blocking both flow paths using the switching means, thereby preventing excessive pressure rise or pressure drop (positive pressure state) of blood inside the oxygenator. However, even better fluid retention and backflow prevention effects can be obtained, and these effects are even better than the first one.
The step of blocking both flow paths by the second communication means, and the first and second communication opening/closing means. Second
This can be further improved by including a step for ensuring the operation of the alert means.

[Example] Hereinafter, the present invention will be described in detail with reference to the accompanying drawings.

FIG. 1 shows a cross-sectional structure of a hollow fiber oxygenator according to a first embodiment of the present invention. In the figure, l is a cylindrical housing that covers the blood processing section where gas exchange between carbon dioxide and oxygen in the blood takes place, and a hollow fiber bundle 3 is disposed inside this housing 1. . Although porous hollow fibers are generally used as gas exchange membranes constituting the hollow fiber bundle 3, it is preferable to use a diffusion membrane in this embodiment. In other words, unlike porous hollow fibers, there is no direct communication between the inside and outside of a diffusion membrane, so in the unlikely event that
When positive pressure is generated in the circuit, there is no risk of air bubbles entering the blood or destruction of blood cells. It can be obtained by

Both ends of the hollow fiber bundle 3 have their openings exposed through partition walls 2a and 2b made of polyurethane resin, respectively, and
The fluid inlet 16a and the fluid outlet 16b are formed and supported and fixed in a liquid-tight manner, thereby configuring the aforementioned blood processing section. A blood inflow space 4 and a blood outflow space 5 are provided at both ends of the hollow fiber bundle 3, corresponding to the fluid inlet 16a and the fluid outlet 16b, respectively. A conical flexible member 6 having an opening 4a at its tip is disposed above one of the partition walls 2a.
The flexible member 6 and the partition wall 2a form the blood inflow space 4.
are divided into sections.

The flexible member 6 is formed of, for example, a flat film of silicone resin, is deformable by fluid pressure described below, and is configured to reciprocate in the direction of the partition wall 2a. A peripheral edge 6a of the flexible member 6 is fixed to the upper edge of the cylindrical body l.

Furthermore, a working chamber forming member 7 is disposed outside the flexible member 6. The working chamber forming member 7 has a blood conducting lower a formed in the center thereof, and the opposing surface of the blood conducting lower a is open, and there is a gap between the working chamber forming member 7 and the flexible member 6. The working chamber 8 is divided into sections. The working chamber forming member 7 is fitted into the edge portion of the housing 1 by a rim 7b provided at its open end, and is tightly fixed onto the periphery of the flexible member 6. The opening 4a provided at the tip of the flexible member 6 is fixed in communication with a blood conduction lower a provided in the working chamber forming member 7. Also,
A check valve 9 is disposed inside the blood conduction lower a, and the check valve 9 allows blood to be introduced into the blood inflow space 4, but conversely, the flow of blood into the blood inflow space 4 is controlled by the check valve 9. The blood is prevented from being drawn out from the blood conduction lower a.

Furthermore, the working chamber forming portion, member 7, is provided with a fluid pressure supply lower c. A fluid pressure applying means, for example, a pressure controller IO is connected to this fluid pressure supply lower C, and is adapted to apply fluid pressure to reciprocate the flexible member 6 within the working chamber 8. .

This pressure controller 10 is a device that can freely control the state of pressure application in the working chamber forming member 7, and for example, turns on/off the supply of compressor air created within the device or introduced from outside the device to the pressure controller IO. Conventional artificial lung pumps include a solenoid valve that turns on and off the release of the pressure added to the pressure controller to atmospheric pressure, and a control unit that controls the timing of these solenoid valves. It is lighter, more compact, and easier to manufacture than.

Further, a peripheral edge portion 11a of a conical spatula 11 is adhesively fixed to the peripheral edge portion of the housing l to which the other partition wall 2b is fixed. The header 11 and the partition wall 2b define the fluid outflow space 5. This header 1
An annular member 12 is fixed to the outer circumferential surface of the adhesive portion between the peripheral edge lLa of the header 1 and the partition wall 2b to strengthen the fixation of the header 11 to the housing l. A blood communication port 11b is provided at the center of the tip of the header 11. A reverse valve 13 is disposed inside the blood passage port 11b, and is paired with the check valve 9 to constitute a passage opening/closing means for preventing backflow. Blood outlet 11b of section 5
Although it is allowed to lead out from the outflow space 5, it is prevented from being introduced into the outflow space 5. Note that 15 indicates an inlet for oxygen-containing gas, and 14 indicates an outlet for gas after gas exchange.

With the above configuration, the hollow fiber of this example can be used in an oxygenator.
When gas or liquid is introduced into the working chamber 8 from the pressure controller 10 through the fluid pressure supply lower c, the flexible member 6 reciprocates due to the fluid pressure, and the reciprocating movement of the flexible member 6 causes the fluid to flow in. Blood pressure fluctuations occur within the space 4. Due to this pressure fluctuation and the action of the two check valves 9.13, the blood introduced from the blood conduction lower a is moved through the hollow fiber bundle 3 from the fluid inflow space 4 side to the fluid outflow space as shown by the arrow in the figure. It flows smoothly toward the part 5 side, and on the way, gas exchange is performed with the oxygen-containing gas introduced from the gas inlet 14.

As described above, since the hollow fiber oxygenator according to this embodiment has a pump built into the main body, a roller pump or the like for blood supply is not particularly required. therefore,
There is no need to assemble the system by connecting the main body and the pump using piping or tubes, which is required in the past, and the time and effort required for assembly is reduced. In other words, since a roller pump pumps out blood by squeezing the tube from the outside, the circuit is set up (connecting each component with a tube), and then it is fitted into the roller part of the roller pump. Needs to be set on roller pump. On the other hand, in this oxygenator, the circuit assembly and connection to the pressure controller lo can be done in parallel, making the work easier, and the installation area of the system can be reduced compared to conventional systems. .

In addition, since a roller pump is not required for blood supply, the tube that is set in the roller pump (usually has an enlarged diameter in order to obtain a specified flow rate) and the tubes before and after it. The priming volume is reduced by the volume of the tube, and problems such as blood leakage and contamination due to cracks in the tube do not occur.

Furthermore, since the flexible member 6 reciprocates and introduces the fluid, blood does not stay in the fluid inflow space 4.
Therefore, there is no risk of the occurrence of thrombi or occlusion of the device due to the occurrence of thrombus.

FIG. 2 shows a hollow fiber according to a second embodiment of the present invention in an oxygenator,
FIG. 3 shows the drive circuit for this artificial lung. In this artificial lung, the outflow side of the blood processing section is configured in the same manner as the inflow side of the blood processing section according to the first embodiment, and therefore the flexible member 6 and the working chamber 8 are provided on the inflow side and the outflow side. Each is provided. In FIG. 2, the same components as those in FIG. 1 are designated by the same reference numerals, and the explanation thereof will be omitted.

The artificial lung of this embodiment is arranged so that the blood passes from the bottom to the top inside the blood processing section, but if the blood passes in the opposite direction from the top to the bottom, the working chamber 8 will be under positive pressure. When connected to a positive pressure source, open the blood outflow clamp and close the blood inflow clamp, and when connected to a positive pressure source (or open to atmosphere), open the outflow clamp. By opening the inflow side clamp, the pressure caused by the head difference allows smooth introduction and extraction. This aspect is suitably used for Vv bypass.

The conduction port opening/closing means of the artificial lung of this embodiment is provided in a tube connected to the blood conduction lower a of the blood inflow space 4,
It is composed of, for example, a clamp 40 that serves as a first opening/closing means, and a clamp 41, for example, that is provided on a tube connected to the blood conduction lower a of the blood outflow space 5 and serves as a second opening/closing means. By configuring the communication port opening/closing means using the clamps 40 and 41 in this manner, a better effect of preventing blood clots can be obtained.

In this case, the tube to be clamped has an outer diameter of 5 to 14 mm.
It is preferable that the degree of

Note that the clamp 40.41 is used as the 1.2 opening/closing means.
Instead, a solenoid valve or the like may be used.

The fluid pressure applying means includes a confirmation gauge (CI) which serves as a positive pressure source as a first pressure source that applies negative fluid pressure to the working chamber 8.
-1,0Kg/cm2) with a positive pressure tank 31 and a near compressor 35 for the positive pressure tank, and a positive pressure or atmospheric pressure as a second pressure source that applies negative fluid pressure or atmospheric pressure to the working chamber 8. Comes with a gauge to confirm the source (0.5K
g/cm2~open to the atmosphere), a positive pressure tank 32, a vacuum pump 36 for the positive pressure tank, and a positive pressure application flow path 33 as a first pressure application flow path that communicates the positive pressure source with the working chamber 8. ,
A positive pressure or atmospheric pressure application channel 34 as a second pressure application channel that communicates a source of positive pressure or atmospheric pressure with the working chamber 8, and a switch that can alternately and repeatedly switch one of both channels. For example, it is constituted by three-way solenoid valves 42 and 43. As the switching means, electromagnetic valves may be provided in the positive pressure applying channel 33 and the positive pressure or atmospheric pressure providing channel 34, respectively, and the respective channels may be switched by opening and closing these.

For accuracy, the vacuum pump 36 is preferably a diaphragm type that can operate for a long time, compared to an oil rotary type.
0 times/min (50 m (27 times)) The positive pressure tank 32 has an atmospheric release leak valve 39, and by opening this, the above-mentioned atmospheric pressure can be applied. Also, between the near compressor 35 and the positive pressure tank 31 and the vacuum pump 36
A pressure regulating valve 37 is provided between the positive pressure tank 32 and the positive pressure tank 32 to adjust the source pressure of each tank. Flow control valves 38 are provided between the electromagnetic valves 42 and 43 and the positive pressure tanks 31 and 32, respectively. This flow rate adjustment valve 38 is particularly suitable for low flow i.
! It is preferable that fine adjustment of (0.5 to 10 β/m1n) is possible, and furthermore, a maximum of about several 10127 m1n is preferable.

The three-way solenoid valve 42 constitutes a first switching means and is connected to the fluid pressure supply lower c of the working chamber 8 of the blood inflow space 4, and the three-way solenoid valve 43 constitutes a second switching means, It is connected to the fluid pressure supply lower c of the working chamber 8 of the blood outflow space 5. Furthermore, the piping forming the positive pressure applying flow path 33 and the positive pressure or atmospheric pressure applying flow path 34 in the above circuit is preferably a pressure-resistant vinyl chloride tube with an inner diameter of about 5 mm.

In this artificial lung, each operation of the clamps 40, 41 and the solenoid valves 42, 43 is controlled by a controller 44 constituting a control means, and a communication port opening/closing means provided with these clamps 40, 41 and the solenoid valves 42, 43. and the fluid pressure applying means constitute a driving device that causes blood to pass through the blood processing section.

This drive device, for example, follows each mode described below,
can be controlled.

(Mode 1) In this mode, a control method will be described in which only the flexible member 6 of the working chamber 8 on the inflow side is operated and the flexible member 6 of the working chamber 8 on the outflow side is not operated. Figure 4 (A-F) shows the operation steps of each clamp and solenoid valve, and Figure 5 (A-F) shows the operation steps of each clamp and solenoid valve.
F is a diagram schematically showing the operating state of the flexible member 6 on the inflow side in each step.

That is, first, in the state of step A, the clamp 40
Close. In this step A, the clamp 41 is in a closed state, and the lightning valve 42 is in a state where it is switched to the positive pressure or atmospheric pressure applying flow path 34, so the working chamber 8 is in a positive pressure or atmospheric pressure state, and the flexible The member 6 is in the suction state.

Next, when the clamp 41 is opened (step B) and the solenoid valve 42 is switched to the positive pressure applying flow path 33 (step C), a negative fluid pressure is applied to the inside of the working chamber 8, and the inside of the working chamber 8 is brought into a positive pressure state. This causes the flexible member 6 to be pressed. As a result, the pressure of the blood in the blood inflow space 4 increases, the blood passes through the blood processing section and is pushed toward the blood outflow space 5, and the blood in the blood outflow space 5 flows through the blood conduction lower a. It is derived from Note that the opening of the clamp 41 and the switching of the solenoid valve 42 may be performed at the same time or in reverse. be.

Next, the clamp 41 is closed (step D), then the clamp 40 is opened (step E), and then the solenoid valve 42 is switched to the positive pressure or atmospheric pressure applying channel 34 (step F).
Then, a negative fluid pressure is applied to the inside of the working chamber 8, and the inside of the working chamber 8 becomes a negative pressure or atmospheric pressure state, whereby the flexible member 6 returns to its original state (suction state) (step F). . As a result, the pressure of the blood in the blood inflow space 4 decreases, and blood is introduced into the blood inflow space 4.

In addition, in each step D, E, and F, each D
It is also possible to do E, E, F, D, E, and F at substantially the same time.

Thereafter, the process returns to step A and the above steps are repeated in sequence.

It is preferable that each step described above is adjusted within a range of 0.1 seconds and within 2.0 seconds so that the next step can proceed. However, step C.

As for step F, it is preferable that the vehicle position be 0.1 seconds and variably adjusted within a range of 30 seconds so that the next step can be proceeded to.

(Mode 2) In this mode, the operating steps of each clamp and solenoid valve are shown in Fig. 6 (A-H), and the operating state of the flexible member 6 in each step is schematically shown in Fig. 7 (A-F). As shown, this is a control method for operating the flexible members 6 of the working chambers 8 on the inflow side and the outflow side, respectively.

First, in step A, the clamp 40 is closed. At this time, the clamp 41 is in a closed state, and the solenoid valve 42 is in a positive pressure or atmospheric pressure applying channel 34. The electromagnetic valve 43 is connected to the positive pressure applying flow path 33
The working chamber 8 on the inflow side is in a positive pressure or atmospheric pressure state, and the working chamber 8 on the outflow side is in a positive pressure state.

Therefore, the flexible member 6 on the inflow side is in a suction state, and the flexible member 6 on the outflow side is in a pressed state.

Next, the solenoid valve 43 is switched to the positive pressure or atmospheric pressure supply channel 34 (step B), and the solenoid valve 42 is switched to the positive pressure supply channel 34.
(Step C), the inside of the working chamber 8 on the outflow side becomes a positive pressure or atmospheric pressure state, and the inside of the working chamber 8 on the inflow side becomes a positive pressure state, whereby the flexible member 6 on the outflow side is sucked,
The flexible member 6 on the inflow side is pressed. As a result, the blood in the blood inflow space 4 passes through the blood processing section and is forced into the blood outflow space 5 side. Note that switching of the electromagnetic valve 43 and switching of the electromagnetic valve 42 may be performed at the same time or in reverse.

Next, open the clamp 41 (step D), and open the solenoid valve 43.
When the flow path 33 is switched to the positive pressure applying channel 33 (step E), the flexible member 6 on the inflow side is pressed and the flexible member 6 on the outflow side is also pressed, whereby the blood in the blood outflow space 5 is is led out from the blood passage port. In addition, the above clamp 4
The opening of the valve 1 and the switching of the solenoid valve 43 may be performed simultaneously or in reverse.

Next, after closing the clamp 41 (step F), opening the clamp 40 (step G), and then switching the solenoid valve 42 to the positive pressure or atmospheric pressure applying channel 34 (step H), the inflow side working chamber 8 becomes in a positive pressure or atmospheric pressure state, therefore, the flexible member 6 on the inflow side becomes in a suction state, and blood is introduced into the blood inflow space 4 (step H). In addition,
In each step of F, G, and H, F and G, respectively,
It is also possible to perform G and H, or F, G and H at substantially the same time.

Thereafter, the process returns to step A and the above steps are repeated in sequence.

In addition, it is preferable that each step described above is variably adjusted within a range of 0.1 second vehicle position and 2.0 seconds, and the transition to the next step can be made. However, step C,
It is preferable that steps E and H be variably adjusted within a range of 0.1 seconds and within 30 seconds so that the next step can be proceeded to.

(Mode 3) Similar to Mode 2, this mode is a control method for operating the flexible members 6 of the working chambers 8 on the inflow side and the outflow side. The operating steps of each clamp and solenoid valve in that case are shown in FIG. 8 (A-H), and the operating state of the flexible member 6 in each step is shown in FIG. 9 (A-H).

First, in step A, the clamp 40 is closed. At this time, the clamp 41 is in a closed state, and the electromagnetic valves 42 and 43 are in a state where they are switched to positive pressure or atmospheric pressure applying flow path 34, respectively.

Next, open the clamp 41 (step B), and open the solenoid valve 42.
to the positive pressure applying channel 33 (step C1, solenoid valve 4
3 to the positive pressure applying channel 33 (step D), the working chamber 8 on the inflow side and the working chamber 8 on the outflow side become in a positive pressure state, and therefore the flexible members 6 on the inflow side and the outflow side are in a pressed state. As a result, the blood in the blood inflow space 4 passes through the blood processing section and is pushed into the blood outflow space 5, and the blood in the blood outflow space 5 is led out from the blood conduction lower a. Blood in the blood outflow space 5 is led out from the blood conduction lower a.

In addition, in each step, take A and B, B and C2C,
It is also possible to do A, B, and C, B and C, or A, B, C, and D substantially simultaneously. Furthermore, after step A,
It is also possible to do it in the order of C, D, H.

Next, the clamp 41 is closed (step E), then the clamp 40 is opened (step F), and then the solenoid valve 42 is switched to the positive pressure or atmospheric pressure applying channel 34 (step G).
), the working chamber 8 on the inflow side is brought into a positive pressure or atmospheric pressure state, and therefore the flexible member 6 on the inflow side becomes in a suction state, thereby introducing blood into the blood inflow space 4 .

Next, when the solenoid valve 43 is switched to the positive pressure or atmospheric pressure applying channel 34 (step H), the working chamber 8 on the outflow side becomes in a positive pressure or atmospheric pressure state, and therefore the flexible member 6 on the outflow side
enters the suction state, whereby the blood in the blood processing section is pushed into the blood outflow space 5, the blood in the blood inflow space 4 enters the blood processing section, and the blood is further introduced into the blood inflow space 4. Ru.

In addition, in each step, E and F, F and G, G and H,
E, F, and G, F, G, and H, and E, F, G, and H can also be performed substantially simultaneously.

It is preferable that each step described above is variably adjusted within a range of 0.1 seconds and within 2.0 seconds, as in mode 1, so that the next step can proceed. However, step C
, for step D, step G, and step H, 0
．． It is preferable to use a device that can be variably adjusted within a range of 1 second and within 30 seconds and can move to the first step.

(Mode 4) This mode is the above-mentioned mode 1 with step C' added between steps C and D, and step F' added between steps F and A, as shown in Figure 1O. be.

That is, after step C, in step C', the positive pressure applying flow path 33 and the positive pressure or atmospheric pressure applying flow path 34 are shut off, and then step D is performed.

However, in step C, the working chamber 8 becomes a positive pressure state, and the blood in the blood inflow space 4 is pushed into the blood outflow space 5. However, when the clamp 41 becomes closed during the pushing, the working chamber 8 is pushed into the blood outflow space 5. Despite the positive pressure state, blood is not drawn out from the blood conduction lower a, and there is a risk that the blood will have nowhere to go. Therefore, before step D of closing the solenoid valve 43, the solenoid valve 42 shuts off both of the flow paths, and from then on, neither negative fluid pressure nor positive fluid pressure is applied to the working chamber 8. This is an attempt to eliminate fear.

In the case of step F', when the clamp 40 is closed while the working chamber 8 is in a positive pressure state, the inside of the hollow fiber becomes a positive pressure state, and if the hollow fiber is porous, for example, the outer periphery There is a risk that air may enter from the
Both flow paths are shut off at ', and then step A is performed.

The other operations are the same as those of the controller 1, and the explanation will be omitted.

In addition, in FIG. 10, the valve states that are close to each other are those with positive pressure, the flow path 33, and the flow path 3 with positive pressure or atmospheric pressure E1.
4'', which shows the state in which all four are cut off, is the same as in Figures 11 and 12.

(Mode 5) In this mode, as shown in FIG.
Slab C'C- after step C and before D, step E' after step E and before F, step! Step H' is added after 1 and before A.

In step C', the solenoid valve 42 is connected to the positive pressure applying channel 33, in step C'', the solenoid valve 4;
Any positive pressure [, < is atmospheric pressure, for example, and the supply flow path 34 is also cut off to eliminate excessive pressure W and pressure drop (positive pressure state) inside the oxygenator, as described in Section 4 above. It eliminates such fears.

Other operations are similar to mode 2.

(1,000-do 6) -1-do is 7-do 3 as shown in Figure 12.
After step D, step ■)'I
)", step [1 after A before 6.nisdep I('
11" is added.

In step D', the solenoid valve 42, in step D'', the solenoid valve 43, in step H', the solenoid valve 42, and in step 11-, the ai solenoid valve 43 is connected to the positive pressure applying channel 33.
When the positive pressure and the positive pressure l-7<, the atmospheric pressure E1 supply flow path 34 is also cut off to eliminate the fear described in Mode 4.

Other operations (J, same as mode 3).

Thereafter, return to step A and repeat steps 51 and 51 in sequence.

In both modes 1 to G, by sequentially repeating each step, blood conduction is established from the blood conduction lower a of the blood inflow space 4 through the blood processing section to the blood outflow space 5.
The blood flows smoothly in the layer 7a, and stagnation of blood in the blood inflow space 4 and the blood outflow space 5 can be effectively prevented.

FIG. 13 shows a drive circuit for a hollow fiber plastic oxygenator according to a third embodiment of the present invention. This artificial lung operates only the flexible part 6 on the inflow side of the blood processing section, and in the fluid pressure chi τ1 providing means, the first pressure that communicates the positive pressure tank 31 and the working chamber 8 is A solenoid valve 45 constituting a first communication stage that enables communication or isolation of the flow path is disposed in the flow path 33, and a solenoid valve 45 is provided in the positive pressure tank 3.
2 and the working chamber 8.
A solenoid valve 45 constituting a second communication means for communicating or blocking the flow path is disposed. That is, the solenoid valve 45
．． 46 constitutes the passage means.

In FIG. 13, the same components as those in the second embodiment described above are given the same reference numerals, and the explanation thereof will be omitted.

The human lung configured in this manner can drive the conduction [-1 opening/closing means, fluid pressure, etc.] supplying means, for example, in the seventh mode described below.

(Mode 7) The mainland mode is based on the above-mentioned mode 4, as shown in FIG.

First, after the step F' of closing the clamp 40, the time required to complete the closing operation of the clamp 40, for example, Q
, 2 seconds later! , ``The solenoid 946 is in the shut-off state (step A in FIG. The clamp 41 is opened after a period of time, e.g., O, 1 second (step B), and after step B, the solenoid valve 45 is opened after a period of time, e.g., 0.1 seconds, required for the clamp 40 to complete the opening operation Y. (Step C).This results in
Clap 40, 41 and solenoid valve 45 in step C
．． 46 is in a state similar to step C in mode 4.

Next, at substantially the same time as the solenoid valve 45 is brought into the cut-off state (indicated by a closed circle in FIG. 14), the valve 41 is closed and the solenoid valve 46 is brought into the open state (Step C') Step C' After that, the inside of the tube that constitutes the flow path 34 and the working chamber 8
The clamp 40 is opened within the time required for the pressure to change from a positive pressure state to a positive pressure state, for example, after 0.2 seconds (step E
).

According to this mode 7, the operation timings of the clamps 40, 41 and the solenoid valves 45, 46 are shifted so that the next step can be started after each operation is completely completed, and the sharp blood flow inside the oxygenator is made possible. The effects described in Mode 4, such as being able to avoid peak pressure, can be further improved.

Moreover, this mode 7 can be executed by operating only the flexible member 6 on the inflow side, and therefore the structure of the oxygenator is simplified.

Note that it is effective to set the above-mentioned timing shift according to the chain volume, compliance, and cylinder opening/closing speed.

Further, when the hollow fibers of the oxygenator are a homogeneous membrane, the pressure of the fluid applied to the working chamber 8 by the positive pressure source may be in a positive pressure state, and when the hollow fibers are microporous, may be, for example, about 1 OmmHg higher than atmospheric pressure.

(Experiment Example 1) Hollow fibers were made of artificial lung Caviox ITO8 (Terumo Corporation)
(manufactured by J.D., membrane area: 0.8 m2) was basically used. Specifically, according to the first example, first, a porous hollow fiber membrane whose pores were filled with silicone resin to form a diffusion membrane was used as the hollow fiber.

Next, a flexible member 6 forming the blood inflow space 4 is made of silicone rubber with a film thickness of 100 μm, and an operating chamber 8, a pressure controller IO, and check valves 9 and 13 are provided, respectively. I got an artificial lung. As shown in FIG. 15, this artificial lung is attached to a blood circulation circuit consisting of a blood storage layer 21 and circuit tubes 22 and 23, with the blood inflow space 4 located at the bottom and the blood flowing from the bottom to the top. Then, briming was performed with 5 U/cc heparinized blood. The inner diameter of the circuit tube 22 was 8ITiffi, and the inner diameter of the circuit tube 23 was 6ITiffi. Pressure controller 10
Using the apparatus described in the examples, the fluid pressure was 0.2 to 0.7.
kg/c+++" and open to the atmosphere (kg/c+++2). Also, the volume of the blood inflow space 4 made up of the flexible member 6 when opened to the atmosphere (this circuit system (head 100 cm) The volume of the blood inflow space (when the pressure was applied to the flexible member) was 32 m12. Then, the fluid pressure pattern of the pressure controller 10 was changed by the near compressor 24, and the flow rate was measured. As a result, the atmosphere was opened for 0.9 seconds, and the fluid pressure was 0.5 kg.
/cm2.920aj2/ by repeating 0.7sec
A blood flow of min. min was obtained, and no air bubbles were mixed into the blood or destruction of blood cells occurred.

(Experiment Example 2) The hollow fiber was used as an oxygenator caviox ll08 (Terumo Corporation).
(manufactured by J.D., membrane area: 0.8 m2) was basically used. Specifically, according to the third example, first, a porous hollow fiber membrane whose pores were filled with silicone resin to form a diffusion membrane was used as the hollow fiber.

Next, a flexible member 6 that forms the blood inflow space 4 is made of silicone rubber with a film thickness of 200 μm, and the conduction port is opened and closed by a clamp, a solenoid valve, etc. as shown in FIG. A device equipped with means and fluid pressure applying means was obtained.

As shown in FIG. 15, the blood inflow space 4 is positioned at the bottom, and the blood storage layer 2 is positioned so that the blood flow is from the bottom to the top.
1 and circuit tubes 22 and 23, and was primed with 5 U/cc heparinized blood. Note that the inner diameter of the circuit tube 22 was 8 mm, and the inner diameter of the circuit tube 23 was 6 mm. The pressure of the positive pressure tank 31 shown in FIG. The volume of the blood inflow space 4 (the volume of the blood inflow space in this circuit system (when pressure with a head of 100 cm is applied to the flexible member)) was 32 mβ. Then, according to mode 7,
l cycle 3.4 sec, Osee in step A
Then, step B-F is changed to O in step B.
, 1 sec, 0.2 sec in step C, 2, 0 sec in step C', 2°2 sec in step I, 3.2 sec in step I
7, and the flow rate was measured. As a result, a blood flow rate of 550 mA/min was obtained, and no air bubbles were mixed into the blood and no GJ destruction of blood cells occurred.

The present invention has been described below with reference to Examples, but the present invention is not limited to the Examples described in F. . For example, in the first embodiment, the flexible member 6 is provided on the blood inflow space 4 side, but it may also be provided on the blood outflow space 5 side, or It may also be configured to be provided on both sides. In addition, in the third embodiment, the flexible portion 1.4'6 is attached to the blood inflow space 4 side by m&
j, but it may be provided on the blood outflow space 5 side.

Furthermore, the present invention can also be applied to fluids other than blood, such as industrial water treatment equipment, gas treatment equipment, and the like.

[Advantageous Effects of the Invention 1] As explained above, the fluid treatment device of the present invention is provided with a fluid inlet opening/closing means that can make each of the fluid inlet ports conductive or cut-off, and directs the flow in one direction, and in addition, the fluid inlet space is At least a portion of the wall means delimiting the fluid outflow space and/or the fluid outflow space is controlled by the fluid pressure! 4: It is formed of a flexible member that can be more deformed, and an operating chamber is provided on the outside of the flexible member; Due to the reciprocating movement of the flexible member, the fluid is passed through the fluid processing section with a pressure fluctuation of 111g in the fluid outflow space 6 and/or the fluid outflow space. There is no need for a pump for supply, and there is no need to assemble the system by connecting the main body and the pump with piping or chikubu as in the past, so it does not take more than 10 minutes to assemble. The installation area of the system can be reduced compared to conventional systems. Furthermore, the amount of pressure required to connect the pump to the pump is reduced by the length of the tube, etc. required. Furthermore, since a roller pump is not required for fluid supply, problems such as fluid leakage and contamination due to cracks in the tube do not occur.

Furthermore, the flexible member reciprocates: 1. The fluid passes through the fluid processing section from T', and the fluid flow is regulated in one direction by the action of the pair of communication port opening/closing means. Since the fluid flows smoothly to the fluid communication port on the outflow space side, it is possible to prevent stagnation in the fluid inflow space and the fluid outflow space, and
When used as an oxygenator, there is no need to provide a venous reservoir or positive pressure prevention gouyan bar, so it is possible to prevent stagnation in the circuit due to this, and therefore, the occurrence of various adverse effects such as blood clots associated with these can be prevented. ni: has the effect of being able to.

Further, in the fluid processing device, the communication port opening/closing means includes first and second opening/closing means, and the fluid pressure applying means comprises the first opening/closing means.
By providing a switching means capable of switching both the pressure E 45 flow path and the second pressure E 45 flow path and the second pressure E 1 supply flow path so that they can communicate or shut off, fluid communication between the fluid inflow '' and the -] passes through the fluid processing section to the fluid conduction section 1 of the fluid outflow space, and the fluid flows more smoothly, thereby effectively preventing fluid stagnation and backflow.

Furthermore, in the method of driving a fluid treatment device, the first method is as follows. The opening/closing operation of the second opening/closing means, the switching operation of the opening/closing means, or the first. By sequentially repeating the communication and blocking operations of the second oil cut, and the operation of blocking both flow paths, the fluid flow is made even smoother.
The retention and backflow prevention effects were well achieved).

[Brief explanation of drawings]

1 is a longitudinal cross-sectional view of a hollow fiber oxygenator according to a first embodiment of the present invention, FIG. 2 is a longitudinal cross-sectional view of a hollow fiber oxygenator according to a second embodiment i; The figure shows the drive circuit for the person's L lungs, No. 4.6, 8゜1 (). 11.12 is an explanatory diagram showing the operation steps of the clamp and solenoid valve in modes 1 to 6, respectively, and 5.7.
Figure 9 shows each subtitle from 1 to 3.
Schematic diagram showing the operating state of the flexible member in the tube, first
3 is a diagram showing a drive circuit for a hollow fiber oxygenator according to the third embodiment, FIG. 14 is an explanatory diagram showing the operation steps in mode 7, and FIG. 15 is based on the first embodiment of the present invention. FIG. 2 is a configuration diagram of a circuit used in an experimental example. ■...Cylindrical body, 2a, 2b...Partition wall 3.
...Hollow fiber bundle, 4...Blood inflow space 5...
Blood outflow space, 6... flexible member 7a, ll
a...Blood communication port, 8...Working chamber 9.13...
- Check valve, 10... Pressure controller 33... Positive pressure application channel,

Claims (1)

[Scope of Claims] (1) A fluid processing section having a fluid inlet and a fluid outlet, and a pair of fluid inlet spaces each provided corresponding to the fluid inlet and the fluid outlet and each having a fluid communication port. and a fluid outflow space, the fluid treatment device includes a pair of backflow prevention devices that enable the fluid communication ports to be connected or blocked, respectively, and direct the flow of fluid from the fluid inflow space to the fluid outflow space. a deformable flexible member provided on at least a part of the wall means that partitions the fluid inflow space and/or the fluid outflow space; and a deformable flexible member provided on the outside of the flexible member. a working chamber provided therein, and a fluid pressure applying means for applying fluid pressure to reciprocate the flexible member within the working chamber, and the reciprocating movement of the flexible member causes the fluid inflow space and/or A fluid treatment device characterized in that the fluid treatment device is configured to generate pressure fluctuations in the fluid in the fluid outflow space and cause the fluid to pass through the fluid treatment portion. (2) The fluid treatment device according to claim 1, wherein the fluid treatment section includes a hollow fiber bundle. (3) The fluid treatment device according to claim 1, wherein the communication port opening/closing means comprises a check valve. (4) The communication port opening/closing means may be capable of connecting or blocking the fluid communication port of the fluid inflow space with a first opening/closing device capable of conducting or blocking the fluid communication port of the fluid outflow space. a second opening/closing means, the fluid pressure applying means applying a positive fluid pressure within the working chamber;
a second pressure source that applies negative fluid pressure or atmospheric pressure; a first pressure applying channel that communicates the first pressure source and the working chamber; and the second pressure source. 2. The fluid processing device according to claim 1, comprising: a second pressure-applying channel that communicates with the working chamber; and switching means that can switch between communicating and blocking both channels. (5) A first step of bringing the first opening/closing means into a closed state, and after the first step, bringing the second opening/closing means into an open state and switching the switching means on the fluid inflow space side to the a second step of switching to the first pressure applying channel; a third step of bringing the second opening/closing means into a closed state;
After the step, a fourth step of opening the first opening/closing means; and a fourth step of switching the switching means to the second pressure applying channel after the third and fourth steps. 5. The fluid treatment apparatus according to claim 4, further comprising control means for driving said communication port opening/closing means and fluid pressure application means by sequentially repeating each step. (6) The control means may perform a third step after the second step.
Before the step of and after the fifth step,
6. The fluid treatment device according to claim 5, further comprising, before the first step, another step of blocking either of the flow paths by the switching means. (7) The switching means includes a first switching means on the side of the fluid inflow space and a second switching means on the side of the fluid outflow space, and the first switching means closes the first opening/closing means. a second step of switching the second switching means to the second pressure applying flow path and switching the first switching means to the first pressure applying flow path; and a second opening/closing means. a third step of switching the second switching means to the first pressure applying channel; a fourth step of switching the second switching means to the closed state; and a fourth step of switching the second switching means to the first pressure applying channel; A fifth step of opening the means, and a sixth step of switching the first switching means to the second pressure applying channel, and by sequentially repeating each step, the communication port opening/closing means and 5. The fluid treatment device according to claim 4, further comprising a control means for driving the fluid pressure applying means. (8) The control means may perform a third step after the second step.
The method further comprises, before the step, the step of blocking both the flow paths by the first switching means, and the step of blocking both the flow paths by the second switching means, After the third step and before the fourth step, the step further includes the step of blocking both the flow paths by the second switching means, and after the sixth step and before the first step. 8. The fluid treatment device according to claim 7, further comprising the step of blocking both of said flow paths by said first switching means. (9) The switching means includes a first switching means on the side of the fluid inflow space and a second switching means on the side of the fluid outflow space, and the first switching means closes the first opening/closing means. a step of opening the second opening/closing means and switching the first switching means to the first pressure applying flow path and the second switching means to the first pressure applying flow path; a third step of bringing the second opening/closing means into the closed state; a fourth step of bringing the first opening/closing means into the open state; and a fourth step of bringing the first switching means into the second opening state. A fifth step of switching to the pressure applying channel, and a sixth step of switching the second switching means to the second pressure applying channel, and by sequentially repeating each step, the communication port opening/closing means and 5. The fluid treatment device according to claim 4, further comprising a control means for driving the fluid pressure applying means. (10) A step in which the control means blocks both of the flow paths by the first switching means after the second step and before the third step, and the second switching means further comprising the step of blocking both of the flow paths by using the first switching means, after the sixth step and before the first step, blocking both of the flow paths by the first switching means. 10. The fluid treatment device according to claim 9, further comprising: a step of blocking both of the flow paths by the second switching means. (11) A fluid processing section having a fluid inlet and a fluid outlet, and a pair of fluid inlet spaces and fluid outlet spaces provided corresponding to the fluid inlets and fluid outlets, respectively, and each having a fluid communication port. and a pair of backflow prevention conduction port opening/closing means that can respectively make the fluid conduction ports conductive or cut-off and direct the flow of fluid from the fluid inflow space to the fluid outflow space. , a deformable flexible member provided on a wall means that partitions the fluid inflow space, a working chamber provided outside the flexible member, and a reciprocating member for reciprocating the flexible member within the working chamber. fluid pressure applying means for applying a fluid pressure to cause the fluid to move, and the passage opening/closing means is capable of making the fluid passage opening of the fluid inflow space conductive or shut off.
and a second opening/closing means capable of connecting or blocking the fluid communication port of the fluid outflow space, and the fluid pressure applying means applies a positive fluid pressure within the working chamber. a pressure source and a second pressure source that applies negative fluid pressure or atmospheric pressure; a first pressure application channel that communicates the first pressure source and the working chamber; and the second pressure source and the A second pressure-applying channel that communicates with the working chamber, and a first communication means that enables communication or blocking of the first pressure-applying channel, and communicating or blocking the second pressure-applying channel. a first step of bringing the first opening/closing means into a closed state; and a second step of bringing the second opening/closing means into a closed state after the first step; a third step of opening the second opening/closing means after the second step; and a fourth step of opening the first opening/closing means after the third step. and the steps of
After the fourth step, a fifth step of substantially simultaneously bringing the second opening/closing means into a closed state, bringing the first passage means into a blocked state, and bringing the second passage means into a communicating state. and a sixth step of opening the first opening/closing means after the fifth step, thereby driving the communication port opening/closing means and the fluid pressure applying means; A fluid processing device characterized in that the flexible member is configured to cause pressure fluctuations in the fluid in the fluid inflow space by reciprocating the flexible member, thereby causing the fluid to pass into the fluid processing section. (12) In the fluid treatment device according to claim 4, there is provided a driving method for causing fluid to pass through the fluid treatment section, comprising: a first step of bringing the first opening/closing means into a closed state; Thereafter, a second step of opening the second opening/closing means and switching the switching means on the fluid inflow space side to the first pressure applying channel, and closing the second opening/closing means. a fourth step of opening the first opening/closing means after the third step; and a fourth step of opening the switching means after the third step and the fourth step. a fifth step of switching to the second pressure applying flow path, and each step is repeated in sequence. (13) After the second step and before the third step, and after the fifth step and before the first step, the switching means blocks both of the flow paths. 13. The method of driving a fluid treatment device according to claim 12, further comprising each of the other steps. (14) In the fluid treatment device according to claim 4, the switching means includes a first switching means on the fluid inflow space side and a second switching means on the fluid outflow space side, and A driving method for causing fluid to pass through the first opening/closing means, the method comprising: a first step of closing the first opening/closing means; switching the second switching means to the second pressure applying channel; a second step of switching the switching means to the first pressure applying channel; and opening the second opening/closing means;
a third step of switching the second switching means to the first pressure applying channel; a fourth step of turning the second opening/closing means into a closed state; and a fourth step of turning the first opening/closing means into an open state. and a sixth step of switching the first switching means to the second pressure applying flow path, the driving of the fluid processing device characterized in that each step is sequentially repeated. Method. (15) After the second step and before the third step, a step of blocking both the flow paths by the first switching means; and a step of blocking both the flow paths by the second switching means. further comprising the step of blocking any of the above, after the third step and before the fourth step, the second
further comprising the step of blocking either of the two flow paths by the switching means, and after the sixth step and before the first step, the first switching means shuts off either of the two flow paths. Claim 14 further comprising the step of blocking.
A method of driving the fluid treatment device described above. (16) In the fluid treatment device according to claim 4, the switching means includes a first switching means on the fluid inflow space side and a second switching means on the fluid outflow space side, and A driving method for causing fluid to pass through the first switching means, comprising: a first step of turning the first opening/closing means into a closed state; opening the second opening/closing means; and switching the first switching means to the first switching means. a second step of switching the second switching means to the first pressure applying flow path in the pressure applying flow path; a third step of switching the second switching means to a closed state; and a third step of switching the second switching means to the first pressure applying flow path; a fourth step of opening and closing the opening/closing means; a fifth step of switching the first switching means to the second pressure applying flow path; and a fifth step of switching the first switching means to the second pressure applying channel. A method for driving a fluid processing device, comprising: a sixth step of switching to a flow path, and repeating each step in sequence. (17) After the second step and before the third step, a step of blocking both the flow paths by the first switching means; and a step of blocking both the flow paths by the second switching means. further comprising the step of blocking any of the above, after the sixth step and before the first step, the first
17. The fluid treatment device according to claim 16, further comprising the steps of: blocking either of the flow paths by the switching means; and blocking both of the flow paths by the second switching means. Driving method. (18) A fluid processing section having a fluid inlet and a fluid outlet, and a pair of fluid inlet spaces and fluid outlet spaces provided corresponding to the fluid inlets and fluid outlets, respectively, and each having a fluid communication port. and a pair of backflow prevention conduction port opening/closing means that can respectively make the fluid conduction ports conductive or cut-off and direct the flow of fluid from the fluid inflow space to the fluid outflow space. , a deformable flexible member provided on a wall means that partitions the fluid inflow space, a working chamber provided outside the flexible member, and a reciprocating member for reciprocating the flexible member within the working chamber. fluid pressure applying means for applying a fluid pressure to cause the fluid to move, and the passage opening/closing means is capable of making the fluid passage opening of the fluid inflow space conductive or shut off.
and a second opening/closing means capable of connecting or blocking the fluid communication port of the fluid outflow space, and the fluid pressure applying means applies a positive fluid pressure within the working chamber. a pressure source and a second pressure source that applies negative fluid pressure or atmospheric pressure; a first pressure application channel that communicates the first pressure source and the working chamber; and the second pressure source and the A second pressure-applying channel that communicates with the working chamber, and a first communication means that enables communication or blocking of the first pressure-applying channel, and communicating or blocking the second pressure-applying channel. A driving method for causing fluid to pass through the fluid processing section in a fluid treatment comprising a second passage means for enabling fluid treatment, the method comprising: a first step of bringing the first opening/closing means into a closed state; a second step of placing the second passage means in a blocked state after the first step; a third step of placing the second opening/closing means in an open state after the second step;
After the step, a fourth step of bringing the first passage means into a communicating state, and substantially simultaneously after the fourth step, bringing the second opening/closing means into a closed state and opening the first passage means. a fifth step of placing the disconnection means in a disconnection state and placing the second passage means in a communication state; and a sixth step of placing the first opening/closing means in an open state after the fifth step; A method for driving a fluid treatment device, characterized in that the operation is performed repeatedly.