JPH02299660A - Method for filling liquid medicine into syringe serving also as container - Google Patents

Abstract

PURPOSE:To keep a sterilization of liquid medicine and to shorten a time for filling by closing a vacuum suction circuit and opening a liquid medicine supply circuit so as to fill the liquid medicine into a vacant chamber of an outer cylinder after evacuating that vacant chamber by opening the vacuum suction circuit and closing the liquid medicine supply circuit. CONSTITUTION:A gasket 6 made of rubber is screwed to a plunger rod 5 inserted through an opening 4 of an outer cylinder 2. That gasket 6 is fitted liquid-tightly to the inner face of outer cylinder 2 and freely movable lengthwise. Therefore, if the liquid medicine is filled after setting the tip face 7 of the gasket 6 at a position lcorresponding to a specified volume, the specified volume of liquid medicine can be filled. When the outer cylinder 2 is communicated with a vacuum suction circuit 10, however, pressure inside the outer cylinder becomes negative, the gasket 6 is sucked toward a tip face 8 of inner chamber and there is a fear that the position l can be kept no more. It is possible, therefore, to keep the specified gasket 6 position l by arranging a stopper 21, which has a cross-sectional shape of U and a length corresponding to the position l, between the head 19 of plunger rod and a brim part 20 of the outer cylinder 2.

Description

DETAILED DESCRIPTION OF THE INVENTION Field of the Invention The present invention relates to a method for filling a medicinal solution into an outer barrel of a container-cum-syringe called a prefill filler.

2. Description of the Related Art A first example of a conventional method for filling a drug solution into a container/syringe is, as shown in FIG. Exposing the hole C, insert a gasket l-D made by Com in advance into the outer cylinder A.
Insert the small diameter pipe E into the outer cylinder A through the spout hole C, with the cylinder tip B pointing in one direction, and inject the chemical solution F into the outer cylinder A through the pipe E. In this method, the pipe E is gradually pulled out, and air is discharged from the gap between the pipe E and the spout hole C.

In addition, in a second example of the conventional filling method, as shown in FIG. The hole C is sealed, and then a pipe J is filled with a chemical solution through the opening (2) and inserted into the outer cylinder A, and a predetermined amount of the chemical solution F is filled through the pipe J. Next, as shown in Figure 1-1, fit the gasket ID into the outer cylinder A through the opening (2), and push it toward the liquid level K of the chemical solution F as shown by the dashed line in the figure. advance,
At this time, the air remaining in the chamber H between the gasket D and the liquid level is discharged, and the air is filled by pushing the caskera l-D until it comes into contact with the liquid level K. The air mixed in the chemical solution F is discharged from the opening (2).

Problems to be Solved by the Invention As a method for filling a drug solution into a syringe that also serves as a container, a syringe shaped like a commonly used syringe is used. This is done reliably, and the accumulated air between the chemical liquid surface and the gasket is sufficiently discharged, and the chemical liquid does not flood from the injection port during filling! , “
The requirements for the chemical filling method are that

However, in the first conventional example of the method of filling the chemical solution J shown in FIG. A thin pipe E for filling is inserted into the pipe E, and the filling operation is performed using the pipe E, which not only makes the filling operation difficult, but also causes the filled chemical solution F to leak out from the spout hole C11 along with the discharged air. There is a problem.

In addition, in the second conventional example shown in FIG. As shown in FIG. 11, while pushing the casquel I-D made by Com toward the chemical liquid surface K, the air remaining between the casquella I-D and the chemical liquid surface is discharged, so that the chemical liquid F is There is a problem in that it takes a lot of time to fill, and there is a risk that some air may remain in the chamber H because it is exhausted by the pushing operation of the Caskera L-D. , gasket L-D for the small diameter pipe for discharging residual air.
This requires a means for inserting the vacuum cleaner between the outer tube A and the inner wall of the outer cylinder A, or for operating it inside the vacuum device, resulting in problems such as the need for a large amount of accessory equipment.

There is also the problem that if an excessive pressing force is applied when screwing the plunger rod G to the caskera L-D, the internal pressure of the chemical solution F will increase, causing an unexpected situation in which the cap L may come off. .

In view of the above-mentioned conventional method for filling a container-cum-syringe, the present invention does not involve the above-mentioned method of filling a drug solution that is difficult and requires skill, but allows for easy filling operation and filling of a predetermined amount of drug solution. is carried out reliably, the residual air between the chemical solution surface and the rubber gasket is sufficiently discharged, and excessive internal pressure is not applied when screwing plunger rods 1 to 1 to the gasket during the filling operation. This eliminates the possibility of leakage of the chemical solution due to the cap coming off, and the discharge of residual air in the chamber and filling of the drug solution are performed automatically in a timely manner, the sterility of the drug solution is maintained, and the filling time is shortened. Our goal is to provide an efficient filling method.

Means for Solving the Problems In order to solve the above-mentioned problems, the present invention provides a structure in which the distal end surface of a gasket with a plunger rod fitted into the outer cylinder of a syringe is connected to the distal end surface of the inner chamber of the outer cylinder. After fixing the plunger rod in a position where a chamber with a predetermined volume is formed, the open tip of the outer cylinder is connected to a vacuum suction circuit and a chemical supply circuit, and the plunger rod is The suction circuit is opened, the chemical solution supply circuit is closed, and the vacuum chamber of the outer cylinder is made to have a negative pressure.Then, the vacuum suction circuit is closed, and the chemical solution supply circuit is opened, and the chemical solution is filled into the cavity. When the chemical liquid is filled, the tip of the cylinder is removed from both circuits to perform the chemical filling operation.

Function The present invention has the configuration as shown in -1- below, and when filling the container-cum-syringe with a medicinal solution, the outer barrel 2 of the syringe 1 is opened and opened as shown in FIG. The rubber gasket 6 inserted from the section 4 is screwed onto the end of the plunger rod 5, which is an inner cylinder, and is fitted so as to be liquid-tight with respect to the inner chamber 25 of the outer cylinder 2 and to be able to move forward and backward. The position l of the gasket 6 is set in advance so that a cavity 9 with a predetermined volume is formed between the tip surface 7 of the casket 6 and the inner tip surface 8 of the outer cylinder 2, and the position l is Then, the gasket 6 is fixed by a stopper 21, which will be described later, and the chemical liquid is filled from the cylinder tip 3 toward the cavity 9, thereby obtaining the outer cylinder 2 filled with a predetermined amount of the chemical liquid. In order to hold the aforementioned J-sket [. Stopper 21 of equivalent length
By detachably arranging the vacuum suction circuit 10, which will be described later, the vacuum pressure of the vacuum suction circuit 10 acts on the empty chamber 9, and the casket 6 moves toward the end surface 8 of the inner chamber to move to the position l. The fear of change is eliminated.

On the one hand, as shown in FIG.
and pneumatic equipment such as vacuum tank 23 and three-way control valve 12
A vacuum suction circuit]-- is constituted by the chemical liquid tank 14, a supply pipe 15, a three-way control valve 13, and a pipe 16 connecting the two control valves 12 and 13 to form a chemical liquid supply circuit 11. As shown in FIGS. 1 and 4, the cylinder tip 3 of the outer cylinder 2 is connected to the port 1-A of the control valve 12 of the vacuum suction circuit 10 through a connector 17. Therefore, the cylinder tip 3 is connected to the control valve 12.13.
By selectively operating the , it communicates with both the vacuum suction circuit 10 and the chemical liquid supply circuit 11 . For example, as shown in FIGS. 1 and 5, by operating the control valve 12 to connect the boat B to the vacuum tank 23 and connect the boat 1-A to the tube tip 3, the vacuum suction circuit 10 is activated. The chamber 9 becomes a negative pressure due to the vacuum pressure of the vacuum tank 23, and air is discharged.Then, the control valve 12 is operated to open the vacuum suction circuit 10 as shown in FIG. "If the chemical solution supply circuit 11 is closed by operating the control valve 13, the circuit from the control valve 12 to the empty chamber 9 of the outer cylinder 2 is under negative pressure, so the chemical solution supply circuit 11 Negative pressure is applied to the supply pipe 15 to suck the chemical solution, and the air 9 is filled with a predetermined volume of the drug solution. Next, by removing the barrel tip 3 from the mount 18, it can be handled as a syringe 1 filled with a predetermined amount of drug. Next, when filling the outer cylinder 1 with a new chemical solution, first fill the first
As shown in FIG. 7, the chemical supply circuit 11 is closed by operating the control valve 13, the vacuum suction circuit 10 is closed by operating the control valve 12, and the outer cylinder is closed. After confirming that the tube tip 3 is fitted to the mount 18 of the connector 17, the control valve 12 is operated as shown in FIGS. 17 and 8 to open the vacuum suction circuit 10.
At this point, the circuit from the control valve 12 to the empty chamber 9 of the outer cylinder 2 becomes a negative pressure, and since the chemical solution supply circuit 11 is in the "closed" state, it is in a state before being filled with the chemical solution. -1- By repeating the above-mentioned operation, the same quantitative filling can be performed for the next syringe. Also, the selection operation between the vacuum suction circuit 10 and the drug supply circuit 11 is performed using the sensor. In addition, if a control device such as a solenoid valve is provided in the circuit and electrical control is performed, it can be operated automatically and accurately without manual effort.

Embodiment FIGS. 1 to 8 show an embodiment, and as shown in FIG. 2, the outer barrel 2 of the container/syringe 1 has a needle base 11 of a commonly used injection needle. A rubber gasket l-6 is screwed onto the plunger rod 5, which has a cylinder tip 3 for landing and which is inserted through the opening 4 of the outer cylinder 2. Fitted liquid-tightly into the inner surface of
, and is said to be able to advance and retreat freely. If the tip surface 7 of the gasket 6 is held at a position l where a cavity 9 of a predetermined volume is formed between the tip surface 7 of the gasket 6 and the inner tip surface 8 of the outer cylinder 2, and the chemical solution is filled, a predetermined amount of the drug solution will be filled. An outer cylinder 2 is obtained. Therefore, the position of the tip surface 7 of the gasket 6 is set in advance at the position e of the predetermined capacity, and the filling operation is performed. However, when the outer cylinder 2 is connected to the vacuum suction circuit 10, which will be described later, a negative pressure is generated. As a result, the gasket 6 may be sucked toward the end surface 8 of the inner chamber, and the position β may not be maintained. Therefore, as shown in FIGS. 2 and 3, plunger rod head 1-9
and the flange 20 of the outer cylinder 2, a stopper 21 having a U-shaped cross section as shown in FIG. 3 and having a length corresponding to the position β is detachably attached to the plunger rod 5. Even if vacuum pressure is applied to the gasket 6 and the gasket 6 is suctioned, the presence of the stopper 21 prevents the rod 5 from leaving the gasket 60 at a predetermined position l.
It is held and does not move.

On the other hand, a filling device for filling the container-cum-syringe 1 with a drug solution is a vacuum pump 22. Vacuum is generated by an air source composed of a vacuum tank 23 and accessory equipment (not shown), a three-way control valve 1.2, and an air vibe 24 that connects the control valve 12 and the air source such as the vacuum tank 23. A suction circuit 10 is formed,
The barrel tip 3 of the outer barrel 2 of the syringe 1 is shown in FIGS. 1 and 4.
As shown in the figure, the connector 17 has a mount 18 made by Kono Co., Ltd. which is screwed onto the control valve 12. The outer tube 2 is formed to fit tightly and to be easily detachable when replacing the outer tube 2, and the tube tip 3 is communicated with the vacuum suction circuit 10 via the control valve 12.

Further, as shown in FIG. 1, the three-way control valve 13 is located below the control valve 12, and the port +-C communicating with the chemical solution tank 14 and the port A) to the control valve 12 are open. However, port B is of a shape that is always closed, and includes the control valve 12, the chemical liquid tank 1-4, the supply vibrator 15 protruding into the chemical liquid, and the control valves 12 and 13.
A chemical supply circuit 11 is formed by a pipe 16 that connects the vacuum tank 23 and the The outer cylinder 2 is communicated with
On the other hand, the control valve 13 communicates with a chemical liquid tank 14, and when the control valves 12 and 13 are selectively opened and closed, the cylinder tip 3 is connected to the vacuum suction circuit 10 and the chemical liquid supply circuit 1. The structure is said to be Now, as shown in FIG. 5, the control valve 12 is selectively operated to open port B to the vacuum tank 23 and port A to the cylinder tip 3, while the control valve 13 is selectively operated to supply the chemical solution. circuit 11
When closed, the negative pressure in the tank 23 from the vacuum suction circuit 10+ makes the empty space 9 extending from the cylinder tip 3 of the outer cylinder 2 to the casket 6 negative pressure.

Next, the control valve 12 is operated in the direction of the arrow to close the vacuum suction circuit 10 as shown in FIG. 6, and the control valve 13 is operated in the direction of the arrow to close the chemical supply circuit 11.
If it is opened, the circuit from the control valve 12 to the empty chamber 9 of the outer cylinder 2 is under negative pressure, so the chemical solution supply circuit 11
is a negative pressure, and the chemical solution tank 1 is supplied by the supply vibrator 1-5.
The chemical solution No. 4 is suctioned, and the empty space 9 reaching the tip end surface 7 of the gasket 6 of the outer cylinder 2 is filled to the fullest, and the outer cylinder 2 is filled with a predetermined volume of the chemical liquid. A predetermined volume of chemical liquid is placed in the outer cylinder 2.
When the tube tip 3 is filled with the connector 1-7,
By removing the syringe barrel 1 from the mount 18, a syringe barrel 1 filled with a predetermined volume of drug solution is obtained.

Next, in order to newly fill the syringe 1 with a drug, first operate the control valve 13 to close the drug supply circuit 11 as shown in FIG.
If the control valve 12 is then rotated in the direction of the arrow to connect port A and port B to open the vacuum suction circuit 10, the vacuum suction circuit 10 as described above is opened.
The pressure becomes negative until reaching the empty space 9 of the outer cylinder 2, which is the state before the chemical solution is filled. Next, when the control valve 13 is operated to open the chemical liquid supply circuit 11, the port C is connected to the chemical liquid tank 1.
4, the direction is automatically controlled while operating the two control valves 12 and 13 and checking the filling amount of the outer cylinder 2 of the syringe 1 and the state of the 71 kund, as described above. Filling with the chemical solution can be repeated by switching the valve J2°13.

Effect The present invention is based on the configuration and operation explained above,
It is suitable for commonly used container and syringes,
By fitting a removable stopper between the flange of the syringe outer cylinder and the plunger rod head, the gasket I fitted inside the outer cylinder can be easily fixed at a predetermined volume position. Even if negative pressure is applied by the vacuum suction circuit, the gasket position does not shift, and the opening and closing operations of the vacuum suction circuit and chemical supply circuit are automatically controlled by a predetermined program using a three-way control valve. Discharging the residual air in the chamber and filling the chemical solution can be performed in a timely manner without requiring any skill, and a stopper of a predetermined length can be inserted to fill a predetermined amount of the chemical solution. This has the effect of allowing accurate filling, and since the air pressure can be adjusted during the filling process, there is no excessive internal pressure, and therefore there is no risk of leakage of the chemical solution. Since the work is carried out automatically in a sealed line, the sterility of the chemical solution is maintained.
Moreover, the filling time can be shortened and the operability can be improved.

[Brief explanation of the drawing]

FIG. 1 is an explanatory diagram of a vacuum suction circuit and a drug supply circuit used in an example of implementation, FIG. 2 is a longitudinal sectional view showing a syringe used in the example in use, and FIG. l in figure 2
ll-111 line sectional view, Figure 4 is a vertical cross-sectional view showing the mounting state of the tip of the cylinder shown in Figure 1, Figure 5 is the direction shown in Figure 4 before moving from the vacuum suction circuit to the chemical filling circuit. The operation diagram of the control valve, Figure 6 is the filling operation diagram of the directional control valve in the chemical liquid supply circuit shown in Figure 4, and Figure 7 is the diagram of the filling operation of the directional control valve shown in Figure 4.
Figure 8 is a diagram of the operation of the directional control valve when the outer cylinder is replaced as shown in Figure 4. Figure 8 is a diagram of the operation of the directional control valve when the vacuum suction circuit is switched to the one shown in Figure 4. Figure 9 is a diagram of the operation of the directional control valve when the outer cylinder is replaced as shown in Figure 4. 10th longitudinal side view showing the first example of the injection state into the syringe;
11 is a longitudinal side view showing a second example of the injection state of the conventional container-cum-syringe, and FIG. 11 is a longitudinal side view showing the state of exhausting residual air from the chamber of the syringe shown in FIG. 10. 1: Syringe, 2: Outer tube, 3: Cylinder tip, 5 Nib plunger rod, 6° casket, 7: Tip surface, 8: Inner chamber tip surface, 9: Empty chamber, 10 Vacuum suction circuit, 11: Chemical liquid supply circuit, β position. Patent applicant Yokoshima Rika Sangyo Co., Ltd. Agent Osamu Ichikawa Yoshito
Tatsuya Fuji Figure 2 Figure 3! ! 2-9 ~Ryoji J-Mon Figure 11 Teitouri Neho Seisho (Spontaneous) 1 Indication of the incident Heisei 1st Department General Application No. 1.21091 2 Name of the invention Method for filling drug solution into a container-cum-syringe 3 Amendment Relationship with the case of a person who makes a patent application Patent applicant Takashima Rika Sangyo Co., Ltd. 4 Agent 5 Column 6 “Detailed description of the invention” in the specification subject to amendment 6 Contents of amendment □ Insert chapter. [It should be noted that the configurations of the vacuum suction circuit, chemical liquid supply circuit, and directional control valve are not limited to the illustrated structure, and of course, any circuit configuration that achieves the object of the present invention may be used. "that's all

Claims (1)

[Claims] The plunger rod is fixed by keeping the tip of the gasket with the plunger rod fitted into the outer cylinder of the syringe at a position where a cavity with a predetermined volume is formed between the tip of the plunger rod and the inner tip of the outer cylinder. After that, the opened tip of the outer cylinder is connected to a vacuum suction circuit and a chemical liquid supply circuit, the vacuum suction circuit is opened, the chemical liquid supply circuit is closed, and the empty space of the outer cylinder is set to negative pressure; A container characterized in that the vacuum suction circuit is then closed, the chemical solution supply circuit is opened, the chemical solution is filled into the cavity, and when the cavity is filled with a predetermined amount of the chemical solution, the barrel tip is removed from both circuits. How to fill a dual-purpose syringe with a drug solution.