JPH02212431A - Tampon for improving metrorrhagia and leukorrhea - Google Patents

Abstract

PURPOSE:To obtain the subject tampon, capable of absorbing secretions, such as blood, and having rapid-acting and sustained antitumor and anti-inflammatory action without side effects by impregnating or applying a drug containing Lithospermi Radix, Ligustici Radix and San-chi Ginseng thereto. CONSTITUTION:A tampon for improving metrorrhagia and leukorrhea obtained by blending a fatty or oily base, such as cacao fat, a water-soluble base, such as macrogol, or hydrophilic base, such as hydrophilic vaseline, with Lithospermi Radix, Ligustici Radix and San-chi Ginseng, further, as necessary, adding a preservative or stabilizer, preparing a drug and impregnating gauze or absorbent cotton, etc., constituting the tampon with the resultant drug or applying the drug to the peripheral surface of the tampon.

Description

Detailed Description of the Invention (Field of Industrial Application) This invention relates to a tampon for improving abnormal uterine bleeding and leucorrhoea. The purpose of the present invention is to provide a tampon for improving abnormal uterine bleeding and leucorrhoea, which has fast-acting and long-lasting antitumor and anti-inflammatory effects.

(Background of the Invention) The following are the main causes of abnormal uterine bleeding in women.

■ It is caused by functional abnormalities of the diencephalon, pituitary gland, ovarian system, etc.
This includes menorrhagia and frequent menstruation, and may also be due to endocrine active tumors of the ovary (granulosa cell type, capsular cell type).

■ Caused by uterine tumors, including benign tumors such as subpurpuric fibroids, interstitial fibroids, and supramucous fibroids that arise from the smooth muscles of the uterine body, cervix, and abdomen, as well as malignant tumors such as cervical cancer and uterine corpus cancer. ,
These include chorioepitheloma and uterine sarcoma.

■ Caused by inflammation, including intrauterine pancreatitis and uterine abdominal tuberculosis.

■ Endometrial polyps, cervical polyps, uterine abdominal erosions,
It may be caused by a foreign body in the uterus.

■ This is due to a bleeding diathesis, including abnormal bleeding due to blood diseases such as leukemia and thrombocytopenia.

■ Regarding pregnancy, delivery, and puerperium, in the early stages of pregnancy, miscarriage, ectopic pregnancy, hydatidiform mole, and in the late pregnancy and at the time of delivery, premature birth, placenta previa, placental abruption, and uterine rupture. , cervical laceration, atonic bleeding, retained placenta, placental polyps, etc.

In addition, the main causes of vaginal discharge are vaginitis, and cervical discharge (which causes cervicoabdominal pseudoerythrosis) is usually caused by cervical catarrh; It may also be secreted from tumors that develop in other areas.

(Prior art) Conventionally, in order to search for the cause of abnormal uterine bleeding or leucorrhoea, patients have been treated with histological examination by test scraping of the endometrium, hysterography, hysteroscopy, basal body temperature measurement, After conducting blood tests, etc., appropriate treatment such as surgery or administration of drugs was selected.

For example, in the case of uterine fibroids, the tumor may be surgically removed, or
Those who were inoperable were treated with radiation therapy and androgen therapy to shrink the tumor.

(Problem to be solved by the invention) However, it takes a considerable number of days after abnormal uterine bleeding or leucorrhoea is recognized until appropriate treatment is taken, and until then, sanitary products are used instead. The only way to stop the bleeding was to absorb blood caused by abnormal uterine bleeding, which sometimes made symptoms even worse.

In addition, surgical therapy leaves surgical scars on the abdomen and causes problems such as rejection due to blood transfusions, so it has been limited to patients who cannot be cured with drugs.

Furthermore, when treating with only drugs, it takes a considerable number of days for the patient to be cured because the patient is administered for a long period of time.

In particular, when chemotherapeutic agents such as penicillin are taken orally, there is a risk that side effects such as worsening of physical condition may occur due to bacterial replacement in the intestines.

In view of the above-mentioned circumstances, the industry is developing products that absorb blood and other secretions caused by abnormal uterine bleeding and leucorrhoea, as well as improving abnormal uterine bleeding and leucorrhoea, which have fast-acting and long-lasting anti-tumor and anti-inflammatory effects without side effects. There was a desire to create a tampon for use.

(Means for Solving the Problems) The tampon for improving abnormal uterine bleeding and leucorrhoea according to the present invention is characterized by being impregnated with or coated with a drug containing Shikon, Toki, and Sanshichi. Since it is a tampon for improving leucorrhoea, it solves all of the above problems.

The structure of the tampon for improving abnormal uterine bleeding and leucorrhoea according to the present invention will be explained in detail below.

(Structure of the Invention) In this invention, Shikon, Toki, and Sanshichi are preferably used.

Shikon is a hard purple root belonging to the family Boraginaceae.
ceae purple Lithospermum eryt
hrorhizon 5ie-bold et Zu
ccarini (Lithostrermum of
ficinaLeLinne var, erythr
Orhizo? L Maximowicz) roots, and soft purple roots of Ma of the Boraginaceae family.
croto-mia euchroma pB11
3 (Lithospltrmua euchro
tga ) ioy-1e ) root.

The reason why purple root is used in this invention is that acetylshikonin, the main component of purple root, and shikonin, its hydrolyzate, have antitumor, anti-inflammatory, and granulation growth promoting effects, which can cause abnormal uterine bleeding. This is because it has the ability to cure uterine tumors and intrauterine pancreatitis.

In addition, AngeLic, AngeLic, a
acutilobal (ilaga-wa1 Hokkaitouki (Hokkai Touki) AnlleLica QCut
i-1oba Kitagawa var, 5utt
iyaaae Frikino % KaratoukiAnge
lica 5tnensis (01iver) Di
els and Oninodake An11eLica gigas
Refers to the root of NakBi.

The reason for using Toki in this invention is that it has a sedative and analgesic effect that not only regulates the function of the uterus, but also relieves abdominal pain associated with abnormal uterine bleeding or leucorrhoea.

Furthermore, Sanshichi means Araliaceae: Araliaceae: / PanaX nOtog! nsen
g (l1url(,) p, )l C1H4n(P
anax ranchf HOO, Panax pse
Udo-ginseng Wall.

var, notoginsentt (Burk,)
Hoo et Tseng), Chikisetsu Carrot P
anax japonIcum C, A, 1d6y,
refers to the root of

The reason why 37 is used in this invention is that 37 has an anti-inflammatory effect and also has a hemostatic effect by increasing the number of platelets.

In addition, the above-mentioned Shikon, Toki, and Sanshichi have antiviral, antibacterial, and antifungal effects, so they can cure intrauterine pancreatitis caused by pyogenic bacteria such as Streptococcus, Staphylococcus, Phosphorus, Escherichia coli, and Mycobacterium tuberculosis. It also has effects.

In this invention, in order to further enhance hemostatic and analgesic effects, cinnamon (Lauraceae, Nikkei C) (n.
naaomua 5ittboldri 146iSn
, (C1nnαao-kauct.

Jap, non Nees), white chrysanthemum (Paeoni-aceae Pattoni)
a LactifLora pill, with the outer skin of the root removed), Schisandra (Mognoliacaceae)
eae SchizandraCh
ingnsis BHill, ripe fruits), ripe fruits of
Reh-mannia gLutinosa
1il)□S(h, 1.hueichingensr
s (Chao et 5chih) Hsiao rhizome)
, Umbelliferae LigusticumwaLLichii Fr.
enCh, rhizome), gold sand (Bombycidae Bombycidae)
1 dae Domestic silkworm Bombyx feces),
Paeoniaceae (Paeoniaceae Pag)
onia 5uff-ruticosa And (root bark), anterior row (Labiatae Labiatae 5ch
Stems, branches with flower spikes or flower spikes of Izon Oeta tenuifo Ha 9riq, etc. may be blended.

Drugs are prepared using the above-mentioned Shikon, Toki, Sanshichi, etc., and the amount to be added may be determined as appropriate depending on the symptoms.

The form of the drug is not particularly limited, but in order to provide sustainability, it may be prepared using an oily base such as cacao butter, a water-soluble base such as macrogol or glycerogelatin, or a hydrophilic base such as hydrophilic vaseline. , Sanshichi may be added.

Incidentally, if necessary, preservatives such as methyl paraoxybenzoate and propyl paraoxybenzoate, stabilizers, etc. may be added.

The tampon for improving abnormal uterine bleeding and leucorrhoea according to the present invention is prepared by impregnating gauze, absorbent cotton, etc. constituting the tampon with the drug obtained as described above, or by applying it to the outer circumferential surface of the tampon. be able to.

The tampon used in this invention may be a tampon normally used as a sanitary product, and tampons made of sterilized gauze, absorbent cotton, etc. covered with a polymeric absorbent material are preferably used.

In this invention, it is desirable that the drug be easily absorbed into the vaginal mucosa, and when gauze, absorbent cotton, etc. are impregnated with the drug, for example, the polymer absorbent material that is the outer layer of a tampon may be partially perforated. All you have to do is take measures such as

The tampon for improving abnormal uterine bleeding and vaginal discharge obtained as described above may be used in the same manner as a normal sanitary product tampon.

Examples and test examples of the tampon for improving abnormal uterine bleeding and leucorrhoea according to the present invention will be shown below.

(Example) After melting and mixing 1000 g of sesame oil, 350 g of beeswax, and 25 g of pig intestine at about 80°C, add 90 g of Shikon (powder of dried purple root) and 90 g of toki (powder of dried root of Japanese trumpet). , 90 g of Sanshichi (powder of dried ginseng root) were added and mixed evenly.

This was rubbed through a cloth while hot, then cooled and solidified to form an ointment.

This ointment was applied to the outer circumferential surface of a tampon (trade name: Nislim Tanvac Stampon, manufactured by Tambrands Limited) (approx. 3 g) to prepare a tampon for improving abnormal uterine bleeding and vaginal discharge.

(Test Example 1) 20 female patients with subserosal fibroids were given 3 tampons for improving abnormal uterine bleeding and leucorrhoea obtained in the example.
Changes in symptoms after daily use (once a day, excluding periods during menstruation) were investigated.

As a result, no abnormal uterine bleeding or discharge of leucorrhea was confirmed in 18 patients, and when hysteroscopy was performed on these 18 patients, it was confirmed that the tumors had shrunk or disappeared in 9 patients.

(Test Example 2) Thirty female patients with vaginitis used the tampon for improving irregular uterine bleeding and leucorrhoea obtained in the example for two days (used once a day during menstruation). We investigated the changes in symptoms after the treatment.

As a result, discharge of leucorrhoea was not confirmed in all 30 patients, and when 8 vaginal smears were prepared, fixed, stained, and examined for these 30 patients, vaginitis was found in 23 patients. It turned out that he had fully recovered.

(Effects of the Invention) As detailed above, the tampon for improving abnormal uterine bleeding and leucorrhoea according to the present invention is characterized by being impregnated with or coated with a drug containing Higen, Toki, and Sanshichi. Since it is a tampon for improving uterine bleeding and vaginal discharge, it has the following effects.

The polymeric absorbent materials, gauze, absorbent cotton, etc. that make up the tampon absorb secretions such as discharge and blood, and the drug also acts directly on the vaginal mucosa or endometrium or indirectly by being absorbed from the vaginal mucosa. , prevent abnormal uterine bleeding or vaginal discharge by shrinking or eliminating tumors or recovering from inflammation.

Furthermore, the tampon for improving abnormal uterine bleeding and leucorrhoea according to the present invention is fast-acting and long-lasting because it is inserted directly into the vagina, and has no side effects because the main component of the drug is a crude drug.

Claims (1)

[Claims] (1) A tampon for improving abnormal uterine bleeding and leucorrhoea, characterized by being impregnated with or coated with a drug containing Shikon, Toki, and Sanshichi.