JP7476231B2 - 温熱療法又は熱モニタと共に行われる電気刺激 - Google Patents
温熱療法又は熱モニタと共に行われる電気刺激 Download PDFInfo
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Description
第五の態様において、前述又は後述の態様の1つ又は複数に加えて、又は幾つかの態様の代わりに、電界は電極対によって画定される少なくとも1つのベクトルを横断して送達される。
第七の態様において、前述又は後述の態様の1つ又は複数に加えて、又は幾つかの態様の代わりに、温度センサはがん性腫瘍の中に挿入されるようになされる。
次に図5を参照すると、本明細書の各種の実施形態による医療機器500の概略図が示されている。各種の実施形態において、医療機器500は、1つ又は複数の電界を発生させるように構成された少なくとも1つの電界発生回路を含むことができる。電界発生回路は、ハウジング102内に配置できる。医療機器500は、電界発生回路と通信可能な制御回路構成をさらに含むことができる。制御回路構成は、電界発生回路からの1つ又は複数の電界の送達を制御するように構成されることができる。各種の実施形態において、制御回路構成は、電界発生回路に10kHz~1MHzの範囲から選択された周波数で1つ又は複数の電界を発生させる。各種の実施形態において、医療機器500は植込みハウジング102を含むことができる。植込みハウジング102は内部空間を画定でき、その中に電界発生回路と第一の制御回路が配置される。
幾つかの実施形態において、医療機器は少なくとも1つの温度センサ518を含むことができる。温度センサ518は、腫瘍110の部位における組織の温度を測定し、例えば電界発生の結果であり得る温度変化又は加熱素子による加熱の結果であり得る変化をモニタするように構成されることができる。温度センサ518は、制御回路構成と電気的に通信できる。幾つかの実施形態において、医療機器は少なくとも1つの温度センサ519を含むことができ、これは、例えば健康な組織内等、治療対象領域の中にない組織内に配置される。治療領域から離れた温度センサ519は、治療の結果である温度変化を特定するために温度センサ518と共に使用できる。
幾つかの実施形態において、制御回路構成は電界の電力出力を計算するように構成されることができる。制御回路はまた、例えば電力出力及び電極対の電極108間距離に基づいて、電界内の組織の温度を推定するように構成されることもできる。電力(ワット)は、以下のように電流と抵抗/インピーダンスに関係付けられる:Pavg=I2 rms *R。1ワットは1ジュール/秒と等しい。伝達される熱はq=mCpΔT又はΔT=q/mCpとして特定でき、式中、qはエネルギ(キロジュール)、mは質量、Cpは組織の比熱容量、ΔTは温度変化である。それゆえ、ΔTはI2 rms *R/mCpとして概算できる。幾つかの実施形態において、電極間の距離(D)は質量の代わりとして使用できる。それゆえ、幾つかの実施形態において、ΔTはI2 rms *R/DCpとして概算できる。組織の比熱容量は、約3.6~3.9kJkg-1K-1とすることができる。
幾つかの実施形態において、制御回路構成は、例えばインピーダンス測定に基づいて電界内の組織の温度を推定するように構成されることができる。幾つかの実施形態において、制御回路構成は、例えばインピーダンス測定と電極対の電極108間距離に基づいて電界内の組織の温度を推定するように構成されることができる。医療機器500は、電極対の電極108間の距離に関するデータを受信するように構成されることができる。別の実施形態において、制御回路構成は、例えば測定されたインピーダンスの変化に基づいて電界内の組織の温度変化を推定するように構成されることができる。
幾つかの実施形態において、医療機器500により送達される療法は、電界を発生させることと、腫瘍110で熱を発生させることとを含むことができる。図7は、本明細書の各種の実施形態による医療機器500の概略図である。幾つかの実施形態において、医療機器500は加熱素子722を含むことができる。加熱素子722は、熱を発生させるように構成されることができる。各種の実施形態において、加熱素子722は電極が電界を発生させるのと同時に熱を発生できる。
幾つかの場合に、本明細書において機器はかなりの量の電力を消費し得る。例えば、ジュール加熱はかなりの量の電力を消費し得る。完全に植え込まれたコンポーネントの電力容量は、幾分限定され得る(例えば、植え込まれたバッテリにより提供される総電力容量には限界がある)。そのため、幾つかの実施形態において、システムは体外電源から体内(植え込まれた)コンポーネントに電力を送達するように構成されてよい。
本明細書では様々な方法が想定されており、これには製造方法、使用方法等が含まれるがこれらに限定されない。本明細書の他の箇所に記載のシステム/機器の動作の様々な面は、本明細書の各種の実施形態による1つ又は複数の方法の動作として実行できる。
各種の実施形態において、本明細書のシステム又は装置(又は制御回路構成等のその構成要素)は、電界発生回路に対し、電界を10kHz~1MHzの範囲から選択された1つ又は複数の周波数を使って電界を送達することを指示するように構成されることができる。幾つかの実施形態において、制御回路構成は、電界発生回路に対し、100kHz~500kHzの範囲から選択された1つ又は複数の周波数で電界を送達することを指示するように構成されることができる。幾つかの実施形態において、制御回路構成は、電界発生回路に対し、100kHz~300kHzの範囲から選択された1つ又は複数の周波数で電界を送達することを指示するように構成されることができる。幾つかの実施形態において、制御回路構成は、電界発生回路に対し、1MHzを超える1つ又は複数の周波数で電界を周期的に送達することを指示するように構成されることができる。
Claims (6)
- 1つ又は複数の電界を発生させるように構成される電界発生回路と、
前記電界発生回路と通信する制御回路であって、前記電界発生回路からの前記1つ又は複数の電界の送達を制御するように構成される制御回路と、
前記電界を患者の体内のがん性腫瘍の部位に送達するために少なくとも1つの電極対を形成する2つ以上の植込み型電極と、
前記がん性腫瘍の前記部位における組織の温度を測定するための植込み型温度センサであって、前記制御回路と電気的に通信する植込み型温度センサと、
前記制御回路と少なくとも1つの植込み型電極との間の電気的通信を提供する第一の植込み型リードであって、前記植込み型温度センサが当該第一の植込み型リード上に配置される第一の植込み型リードと、
を含み、
前記制御回路は、前記電界発生回路に10kHz~1MHzの範囲から選択される周波数で、がん性細胞内の細胞有糸分裂を中断させるのに有効な1つ又は複数の電界を発生させ、
前記制御回路は、がん性腫瘍の部位における組織の温度をモニタするように構成されるとともに、前記がん性腫瘍の部位における組織の熱破壊を防止するために前記1つ又は複数の電界を調整するように構成され、
前記制御回路は前記1つ又は複数の電界の電力出力を演算し、当該電力出力及び前記少なくとも1つの電極対の前記2つ以上の植込み型電極間の距離に基づいて、前記1つ以上の電界内の組織の温度を推定する
植込み型医療機器システム。 - 前記電界は前記少なくとも1つの電極対の中の前記植込み型電極間に延びる1つのベクトルに沿って送達される、請求項1に記載の植込み型医療機器システム。
- 前記植込み型温度センサは前記少なくとも1つの電極対の中の前記植込み型電極間に位置付けられる、請求項2に記載の植込み型医療機器システム。
- 前記電界は少なくとも第一のベクトルと第二のベクトルとを横断して送達され、前記第一のベクトルは第一の電極対によって画定され、前記第二のベクトルは第二の電極対によって画定される、請求項1~3の何れか一項に記載の植込み型医療機器システム。
- 前記第一のベクトルに沿った電界と前記第二のベクトルに沿った電界は相互に空間的及び/又は方向的に離れている、請求項4に記載の植込み型医療機器システム。
- 少なくとも2つの電界発生回路を含み、第一の電界発生回路は植え込まれ、第二の電界発生回路は体外に設置される、請求項1~5の何れか1項に記載の植込み型医療機器システム。
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Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11338135B2 (en) | 2017-10-23 | 2022-05-24 | Cardiac Pacemakers, Inc. | Medical devices for cancer therapy with electric field shaping elements |
EP3954314A1 (en) | 2019-02-27 | 2022-02-16 | Novocure GmbH | Delivering tumor treating fields (ttfields) using implantable transducer arrays |
JP2022530872A (ja) | 2019-04-22 | 2022-07-04 | ボストン サイエンティフィック サイムド,インコーポレイテッド | 癌治療のための電気刺激機器 |
WO2020219337A1 (en) | 2019-04-22 | 2020-10-29 | Boston Scientific Scimed, Inc. | Systems for administering electrical stimulation to treat cancer |
EP4356955A2 (en) | 2019-04-23 | 2024-04-24 | Boston Scientific Scimed, Inc. | Electrodes for electrical stimulation to treat cancer |
US11607542B2 (en) | 2019-04-23 | 2023-03-21 | Boston Scientific Scimed, Inc. | Electrical stimulation for cancer treatment with internal and external electrodes |
CN113766950A (zh) | 2019-04-23 | 2021-12-07 | 波士顿科学国际有限公司 | 带有热治疗或热监测的电刺激 |
WO2021123914A1 (en) * | 2019-12-20 | 2021-06-24 | Novocure Gmbh | Treatment assembly for providing tumor treating fields to animal test subjects |
WO2021173509A1 (en) | 2020-02-24 | 2021-09-02 | Boston Scientific Scimed, Inc. | Systems and methods for treatment of pancreatic cancer |
WO2024102325A1 (en) * | 2022-11-10 | 2024-05-16 | Cardiac Pacemakers, Inc. | Implantable medical systems for cancer treatment with thermal management features |
Citations (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050004507A1 (en) | 2000-03-13 | 2005-01-06 | Oncostim. Inc. | Method and device for treating cancer with electrical therapy in conjunction with chemotherapeutic agents and radiation therapy |
US20050096584A1 (en) | 2003-10-29 | 2005-05-05 | Bozidar Ferek-Petric | Implantable electroporation therapy device and method for using same |
US20100217356A1 (en) | 2006-08-21 | 2010-08-26 | Marom Bikson | Method to reduce heating at implantable medical devices including neuroprosthetic devices |
US20100261994A1 (en) | 2009-04-09 | 2010-10-14 | Rafael Davalos | Integration of very short electric pulses for minimally to noninvasive electroporation |
JP2011078804A (ja) | 2004-04-23 | 2011-04-21 | Novocure Ltd | 異なる周波数の電界による腫瘍等の治療 |
US20110224665A1 (en) | 2010-03-11 | 2011-09-15 | Peter Andrew Crosby | Modular stimulator for treatment of back pain, implantable rf ablation system and methods of use |
JP2013544133A (ja) | 2010-10-25 | 2013-12-12 | メドトロニック アーディアン ルクセンブルク ソシエテ ア レスポンサビリテ リミテ | 腎ニューロモジュレーションのためのマルチ電極アレイを有するカテーテル装置ならびに関連のシステムおよび方法 |
US20140350541A1 (en) | 2011-12-13 | 2014-11-27 | Lazure Scientific, Inc. | Control and delivery of electric fields via an electrode array |
JP2016523135A (ja) | 2013-06-05 | 2016-08-08 | メタベンション インコーポレイテッド | 標的神経線維の調節 |
JP2017518805A (ja) | 2014-05-12 | 2017-07-13 | バージニア テック インテレクチュアル プロパティース インコーポレイテッド | パルス電界を使用した細胞の細胞内効果の選択的調節 |
US20170231694A1 (en) | 2004-09-10 | 2017-08-17 | Boston Scientific Scimed, Inc. | Apparatus and method for treatment of in-stent restenosis |
WO2019084021A1 (en) | 2017-10-23 | 2019-05-02 | Cardiac Pacemakers, Inc. | ELECTRIC FIELD CANCER TREATMENT DEVICES COMPRISING FEEDBACK MECHANISMS AND DIAGNOSTICS |
US20200061385A1 (en) | 2015-07-01 | 2020-02-27 | Btl Medical Technologies S.R.O. | Aesthetic method of biological structure treatment by magnetic field |
Family Cites Families (154)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4016886A (en) | 1974-11-26 | 1977-04-12 | The United States Of America As Represented By The United States Energy Research And Development Administration | Method for localizing heating in tumor tissue |
US5099838A (en) | 1988-12-15 | 1992-03-31 | Medtronic, Inc. | Endocardial defibrillation electrode system |
US5324328A (en) | 1992-08-05 | 1994-06-28 | Siemens Pacesetter, Inc. | Conductor for a defibrillator patch lead |
US5397342A (en) | 1993-06-07 | 1995-03-14 | Cardiac Pacemakers, Inc. | Resilient structurally coupled and electrically independent electrodes |
US5582609A (en) | 1993-10-14 | 1996-12-10 | Ep Technologies, Inc. | Systems and methods for forming large lesions in body tissue using curvilinear electrode elements |
US5458597A (en) | 1993-11-08 | 1995-10-17 | Zomed International | Device for treating cancer and non-malignant tumors and methods |
ES2159315T3 (es) | 1994-04-01 | 2001-10-01 | Akzo Nobel Nv | Uso de una banda de sujecion para cerrar recipientes para compuestos quimicos, y un recipiente correspondiente. |
US5755758A (en) | 1995-11-07 | 1998-05-26 | Medtronic, Inc. | Intramuscular stimulation lead with enhanced infection resistance |
US6366808B1 (en) | 2000-03-13 | 2002-04-02 | Edward A. Schroeppel | Implantable device and method for the electrical treatment of cancer |
US20040215296A1 (en) | 1999-11-16 | 2004-10-28 | Barrx, Inc. | System and method for treating abnormal epithelium in an esophagus |
US6549812B1 (en) | 1999-11-29 | 2003-04-15 | Medtronic, Inc. | Medical electrical lead having bending stiffness which increase in the distal direction |
US6853864B2 (en) | 2000-02-02 | 2005-02-08 | Catholic University Of America, The | Use of electromagnetic fields in cancer and other therapies |
GB0002849D0 (en) | 2000-02-08 | 2000-03-29 | Gyrus Medical Ltd | An electrosurgical instrument and an electosurgery system including such an instrument |
US8175698B2 (en) | 2000-02-17 | 2012-05-08 | Novocure Ltd. | Treating bacteria with electric fields |
US8447395B2 (en) | 2000-02-17 | 2013-05-21 | Novocure Ltd | Treating bacteria with electric fields |
US7089054B2 (en) | 2002-10-02 | 2006-08-08 | Standen Ltd. | Apparatus and method for treating a tumor or the like |
US7136699B2 (en) | 2002-10-02 | 2006-11-14 | Standen, Ltd. | Apparatus for destroying dividing cells |
US7146210B2 (en) | 2000-02-17 | 2006-12-05 | Standen Ltd. | Apparatus and method for optimizing tumor treatment efficiency by electric fields |
US6868289B2 (en) | 2002-10-02 | 2005-03-15 | Standen Ltd. | Apparatus for treating a tumor or the like and articles incorporating the apparatus for treatment of the tumor |
CN1416466A (zh) | 2000-02-17 | 2003-05-07 | 约朗姆·帕尔蒂 | 破坏正在分裂的细胞的方法和装置 |
GB0005247D0 (en) | 2000-03-03 | 2000-04-26 | Btg Int Ltd | Electrical impedance method for differentiating tissue types |
US6673623B1 (en) | 2000-09-12 | 2004-01-06 | Novocure, Inc. | Methods and compositions that control lipid production |
WO2002083016A1 (en) | 2001-04-13 | 2002-10-24 | Surgi-Vision, Inc. | Systems and methods for magnetic-resonance-guided interventional procedures |
US7305266B1 (en) | 2001-05-14 | 2007-12-04 | Pacesetter, Inc. | Cardiac stimulation devices and methods for measuring impedances associated with the heart |
US20020198567A1 (en) | 2001-06-07 | 2002-12-26 | Yona Keisari | Electro-endocytotic therapy as a treatment modality of cancer |
JP2003036987A (ja) | 2001-07-24 | 2003-02-07 | Harison Toshiba Lighting Corp | 放電ランプ点灯装置、機器および画像形成装置 |
US6909918B2 (en) | 2001-10-10 | 2005-06-21 | Medtronic, Inc. | Implantable percutaneous stimulation lead with lead carrier |
US7653438B2 (en) | 2002-04-08 | 2010-01-26 | Ardian, Inc. | Methods and apparatus for renal neuromodulation |
US20030204161A1 (en) | 2002-04-25 | 2003-10-30 | Bozidar Ferek-Petric | Implantable electroporation therapy device and method for using same |
AU2003299471A1 (en) | 2002-05-07 | 2004-05-13 | Kai Kroll | Method and device for treating concer with electrical therapy in conjunction with chemotherapeutic agents and radiation therapy |
DE10255858A1 (de) | 2002-11-29 | 2004-06-17 | Evotec Oai Ag | Fluidisches Mikrosystem mit feldformenden Passivierungsschichten auf Mikroelektroden |
US6920361B2 (en) | 2003-02-14 | 2005-07-19 | Medtronic, Inc. | Reverse wound electrodes |
US8346482B2 (en) | 2003-08-22 | 2013-01-01 | Fernandez Dennis S | Integrated biosensor and simulation system for diagnosis and therapy |
US7524274B2 (en) | 2003-11-07 | 2009-04-28 | Cytyc Corporation | Tissue positioning systems and methods for use with radiation therapy |
US20050222646A1 (en) | 2004-04-06 | 2005-10-06 | Kai Kroll | Method and device for treating cancer with modified output electrical therapy |
US7720549B2 (en) | 2004-04-06 | 2010-05-18 | Oncostim, Inc. | Partially implantable system for the electrical treatment of abnormal tissue growth |
US20120277839A1 (en) | 2004-09-08 | 2012-11-01 | Kramer Jeffery M | Selective stimulation to modulate the sympathetic nervous system |
CA2586802A1 (en) | 2004-11-08 | 2006-05-11 | Continence Control Systems International Pty Ltd. | An implantable electrode arrangement |
AU2005301103A1 (en) | 2004-11-08 | 2006-05-11 | Continence Control Systems International Pty Ltd | An implantable electrode arrangement |
US8409111B2 (en) | 2004-11-22 | 2013-04-02 | Bard Peripheral Vascular, Inc. | Removable localizing wire |
EP2161054B1 (en) | 2004-12-07 | 2015-12-02 | Novocure Limited | Electrodes for applying an electric field in-vivo over an extended period of time |
US20060282122A1 (en) | 2005-06-08 | 2006-12-14 | Yoram Palti | Treating cancer with electric fields that are guided to desired locations within a body |
AU2006261666B2 (en) | 2005-06-28 | 2011-05-26 | Bioness Inc. | Improvements to an implant, system and method using implanted passive conductors for routing electrical current |
CN101321555B (zh) | 2005-10-03 | 2020-12-08 | 诺沃库勒有限责任公司 | 优化电场特征以增加电场在增殖细胞上的效果 |
US7616992B2 (en) | 2006-01-30 | 2009-11-10 | Medtronic, Inc. | Intravascular medical device |
US8019414B2 (en) | 2006-04-05 | 2011-09-13 | Novocure Ltd. | Treating cancer using electromagnetic fields in combination with other treatment regimens |
US7899555B2 (en) | 2006-04-11 | 2011-03-01 | Pacesetter, Inc. | Intrapericardial lead |
US7809441B2 (en) | 2006-05-17 | 2010-10-05 | Cardiac Pacemakers, Inc. | Implantable medical device with chemical sensor and related methods |
US20070270916A1 (en) | 2006-05-18 | 2007-11-22 | Fischell Robert E | Cardiac pacemaker with integrated battery |
WO2008034107A2 (en) | 2006-09-14 | 2008-03-20 | Lazure Technologies, Llc | Tissue ablation and removal |
WO2008036548A2 (en) | 2006-09-18 | 2008-03-27 | Boston Scientific Limited | Endoprostheses |
US8728073B2 (en) | 2006-10-10 | 2014-05-20 | Biosense Webster, Inc. | Multi-region staged inflation balloon |
US20080208305A1 (en) | 2007-01-17 | 2008-08-28 | The Cleveland Clinic Foundation | Apparatus and methods for treating pulmonary conditions |
US7844345B2 (en) | 2007-02-08 | 2010-11-30 | Neuropace, Inc. | Drug eluting lead systems |
US7937147B2 (en) | 2007-02-28 | 2011-05-03 | Cardiac Pacemakers, Inc. | High frequency stimulation for treatment of atrial fibrillation |
EP3231480A1 (en) | 2007-03-06 | 2017-10-18 | Novocure Ltd. | Treating cancer using electromagnetic fields in combination with photodynamic therapy |
US8376013B2 (en) | 2008-03-11 | 2013-02-19 | Duke University | Plasmonic assisted systems and methods for interior energy-activation from an exterior source |
CA2696352C (en) | 2007-08-14 | 2017-03-21 | Novocure Limited | Treating parasites with electric fields |
US8562602B2 (en) | 2007-09-14 | 2013-10-22 | Lazure Technologies, Llc | Multi-layer electrode ablation probe and related methods |
US20090076500A1 (en) | 2007-09-14 | 2009-03-19 | Lazure Technologies, Llc | Multi-tine probe and treatment by activation of opposing tines |
US8715203B2 (en) | 2007-09-17 | 2014-05-06 | Novocure Limited | Composite electrode |
TWI348280B (en) | 2008-01-21 | 2011-09-01 | Univ Nat Taiwan | Dual injection locked frequency dividing circuit |
WO2009097527A1 (en) | 2008-01-30 | 2009-08-06 | Transoma Medical, Inc. | Minimally invasive physiologic parameter recorder and introducer system |
US8864677B2 (en) | 2008-03-13 | 2014-10-21 | Cardiac Pacemakers, Inc. | Systems and methods for myocardial ischemia detection |
US8968173B2 (en) | 2008-07-16 | 2015-03-03 | Frank Sivo | Methods to arrest cancer cell growth and proliferation using electromagnetic energy delivered via electromagnetic coil systems |
US8886334B2 (en) | 2008-10-07 | 2014-11-11 | Mc10, Inc. | Systems, methods, and devices using stretchable or flexible electronics for medical applications |
US9155885B2 (en) | 2009-04-24 | 2015-10-13 | Medtronic, Inc. | Incontinence therapy |
TWI423738B (zh) | 2009-04-28 | 2014-01-11 | Masayuki Kumada | A method and apparatus for generating high density hollow electron cloud instantaneously by laser |
EP2429630B1 (en) | 2009-04-30 | 2017-10-25 | Medtronic, Inc | A shielded implantable medical lead with reduced torsional stiffness |
US8340783B2 (en) | 2009-06-30 | 2012-12-25 | Medtronic, Inc. | Implantable medical device lead with selectively exposed electrodes and reinforcement member |
WO2011017049A1 (en) | 2009-07-27 | 2011-02-10 | Cardiac Pacemakers, Inc. | Medical device for treating heart failure through blood volume redistribution |
CN102711902B (zh) | 2009-09-23 | 2015-09-16 | 湖区制造公司,商用名湖区医药 | 导丝型起搏导联 |
CN101693875B (zh) | 2009-09-30 | 2012-04-18 | 重庆大学 | 基于柱状微电极阵列的细胞电融合芯片装置及电融合方法 |
US8543202B2 (en) | 2009-11-25 | 2013-09-24 | Steven M. Goetz | Medical electrical stimulation with external simulated case electrode |
WO2011103133A2 (en) | 2010-02-16 | 2011-08-25 | Angiodynamics, Inc. | Dual bracketed energy delivery probe and method of use |
US9526911B1 (en) | 2010-04-27 | 2016-12-27 | Lazure Scientific, Inc. | Immune mediated cancer cell destruction, systems and methods |
EP2651497B1 (en) | 2010-12-14 | 2019-02-20 | The Regents of The University of California | Extracranial implantable systems for the treatment of medical disorders |
WO2012082900A2 (en) | 2010-12-15 | 2012-06-21 | Boston Scientific Neuromodulation Corporation | Systems and methods for making and using leads for electrical stimulation systems with improved rf compatibility |
US8945207B2 (en) | 2010-12-20 | 2015-02-03 | Graftcraft I Göteborg Ab | Removable stent and method of production |
WO2012103419A2 (en) | 2011-01-28 | 2012-08-02 | Medtronic, Inc. | Implantable medical leads and systems that utilize reflection points to control induced radio frequency energy |
EP2497530A3 (en) | 2011-03-07 | 2013-06-19 | Giancarlo Barolat | Modular nerve stimulation system |
US9295404B2 (en) | 2011-03-30 | 2016-03-29 | Admittance Technologies, Inc. | Low power apparatus and method to measure complex electrical admittance or impedance |
US20150134022A1 (en) | 2011-05-13 | 2015-05-14 | Chong Il Lee | Cell electric stimulator with separate electrodes for electrical field shaping and for stimulation |
DE102011111649A1 (de) | 2011-08-26 | 2013-02-28 | Peter Osypka | Implantierbare Epikardiale Elektroden Anordnung |
JP6522942B2 (ja) | 2011-10-04 | 2019-05-29 | べシックス・バスキュラー・インコーポレイテッド | ステント内再狭窄を治療するためのシステム及び方法 |
CN202365923U (zh) | 2011-12-07 | 2012-08-08 | 北京天助畅运医疗技术股份有限公司 | 肾神经射频消融涂层电极 |
CN104066395B (zh) | 2011-12-15 | 2017-09-05 | 里兰斯坦福初级大学理事会 | 用于治疗肺动脉高血压的设备和方法 |
JP5898336B2 (ja) | 2011-12-23 | 2016-04-06 | べシックス・バスキュラー・インコーポレイテッド | 拡張可能なバルーン及び熱感知デバイスを備えた電極パッドを含むデバイス |
KR102189536B1 (ko) | 2012-01-17 | 2020-12-14 | 아르티오 메디컬 인크. | 팽창성 바디 디바이스 및 사용 방법 |
US20130261706A1 (en) | 2012-03-30 | 2013-10-03 | Neuropace, Inc. | Systems and methods for applying rapid sequential electrode stimulation |
US8923976B2 (en) | 2012-04-26 | 2014-12-30 | Medtronic, Inc. | Movement patterns for electrical stimulation therapy |
EP2664354B1 (fr) | 2012-05-16 | 2015-09-16 | Sorin CRM SAS | Sonde médicale avec une électrode en forme de bague destinée à être implantée dans un vaisseau cardiaque ou cérébral et un procédé pour sa fabrication |
US10195419B2 (en) | 2012-06-13 | 2019-02-05 | Mainstay Medical Limited | Electrode leads for use with implantable neuromuscular electrical stimulator |
US9339655B2 (en) | 2012-06-30 | 2016-05-17 | Boston Scientific Neuromodulation Corporation | System and method for compounding low-frequency sources for high-frequency neuromodulation |
US9282894B2 (en) | 2012-10-08 | 2016-03-15 | Tosense, Inc. | Internet-based system for evaluating ECG waveforms to determine the presence of p-mitrale and p-pulmonale |
US20170050017A1 (en) | 2013-02-25 | 2017-02-23 | Cosman Medical, Inc. | Electrosurgical System |
WO2014160832A2 (en) | 2013-03-27 | 2014-10-02 | Tricord Holdings, L.L.C. | Systems and methods for neurological traffic and/or receptor functional evaluation and/or modification |
US20160068598A1 (en) | 2013-04-12 | 2016-03-10 | University Of Louisville Research Foundation, Inc. | Anti-cd19 compositions and methods for treating cancer |
US9655669B2 (en) | 2013-05-06 | 2017-05-23 | Novocure Limited | Optimizing treatment using TTFields by changing the frequency during the course of long term tumor treatment |
US10779875B2 (en) | 2013-05-06 | 2020-09-22 | Novocure Gmbh | Optimizing treatment using TTfields by changing the frequency during the course of long term tumor treatment |
US9993656B2 (en) | 2013-06-03 | 2018-06-12 | The General Hospital Corporation | Magnetic neural stimulator and method of activation of neural tissue with same |
US9106004B2 (en) | 2013-12-19 | 2015-08-11 | Medtronic, Inc. | Implantable medical electrical leads and connector assemblies thereof |
WO2015100451A1 (en) | 2013-12-27 | 2015-07-02 | M.O.E. Medical Devices Llc | Applying electric field treatment to parts of the body |
US9956035B2 (en) | 2014-03-27 | 2018-05-01 | Biosense Webster (Israel) Ltd. | Temperature measurement in catheter |
US10639098B2 (en) * | 2014-05-06 | 2020-05-05 | Cosman Instruments, Llc | Electrosurgical generator |
US10232167B2 (en) | 2014-05-07 | 2019-03-19 | Medtronic, Inc. | Electrode construction for implantable medical electrical leads |
US10265530B1 (en) | 2014-05-29 | 2019-04-23 | Stimwave Technologies Incorporated | Simulation with electrode arrays |
US9844641B2 (en) | 2014-07-16 | 2017-12-19 | Fractyl Laboratories, Inc. | Systems, devices and methods for performing medical procedures in the intestine |
US9833617B2 (en) | 2014-07-25 | 2017-12-05 | Loyalty Based Innovations, LLC | Apparatus and method for treating multiple tumors in patients with metastatic disease by electric fields |
AU2015307284B2 (en) | 2014-08-27 | 2018-11-01 | Neuronano Ab | Method of implantation of a medical device into neural tissue |
EP3209367A4 (en) | 2014-10-24 | 2018-08-01 | Medtronic Inc. | Coronary sinus medical electrical lead |
US10188863B2 (en) | 2015-02-26 | 2019-01-29 | Medtronic, Inc. | Therapy program selection for electrical stimulation therapy based on a volume of tissue activation |
US9533163B2 (en) | 2015-02-27 | 2017-01-03 | Pacesetter, Inc. | Systems and methods for implantable medical device communication |
CN107405483A (zh) | 2015-03-09 | 2017-11-28 | 皇家飞利浦有限公司 | 离子电渗的设备、装置和方法 |
WO2016149575A1 (en) | 2015-03-19 | 2016-09-22 | Old Dominion University | Synergistic regulated cell death induction with hsp90 inhibitors and nanosecond pulsed electric fields |
CN204698678U (zh) | 2015-04-15 | 2015-10-14 | 杭州睿笛生物科技有限公司 | 纳秒脉冲肿瘤消融阵列电极 |
WO2016168485A1 (en) | 2015-04-17 | 2016-10-20 | David Robinson | An implantable neuro-stimulation device |
AU2016262085B2 (en) | 2015-05-12 | 2020-10-22 | National University Of Ireland Galway | Devices for therapeutic nasal neuromodulation and associated methods and systems |
WO2016179712A1 (en) | 2015-05-14 | 2016-11-17 | London Health Sciences Centre Research Inc. | Intratumoral modulation therapy |
WO2016199142A1 (en) | 2015-06-10 | 2016-12-15 | Hadasit Medical Research Services And Development Ltd. | Implantable monitoring device |
EP3331466A1 (en) | 2015-08-05 | 2018-06-13 | Boston Scientific Scimed, Inc. | Expandable balloon mapping and ablation device |
EP3347085B1 (en) | 2015-09-11 | 2023-07-26 | Nalu Medical, Inc. | Apparatus for peripheral or spinal stimulation |
US9910453B2 (en) | 2015-09-25 | 2018-03-06 | Novocure Limited | High voltage, high efficiency sine wave generator with pre-set frequency and adjustable amplitude |
US20170105793A1 (en) | 2015-10-15 | 2017-04-20 | Boston Scientific Scimed, Inc. | Energy delivery devices and related methods of use |
US10188851B2 (en) | 2015-10-28 | 2019-01-29 | Novocure Limited | TTField treatment with optimization of electrode positions on the head based on MRI-based conductivity measurements |
EP3377607A4 (en) | 2015-11-20 | 2019-12-11 | ACEA Biosciences Inc. | CELL SUPPLY MONITORING OF CANCER CELLS |
WO2017112665A1 (en) | 2015-12-22 | 2017-06-29 | Gupte Akshay Ashok | Systems to provide sympathetic modulation therapy |
KR20180108655A (ko) | 2016-01-15 | 2018-10-04 | 알에프이엠비 홀딩스, 엘엘씨 | 암의 면역학적 치료 |
US10646644B2 (en) | 2016-03-15 | 2020-05-12 | CalXStars Business Accelerator, Inc. | Stimulator, pump and composition |
WO2017173275A1 (en) | 2016-03-31 | 2017-10-05 | Cardiac Pacemakers, Inc. | Implantable medical device with rechargeable battery |
US10821283B2 (en) | 2016-04-04 | 2020-11-03 | Novocure Gmbh | Reducing motility of cancer cells using tumor treating fields (TTFields) |
US9925369B2 (en) | 2016-04-29 | 2018-03-27 | Pacesetter, Inc. | Retrievable intrapericardial electrotherapy lead |
EP3429679B1 (en) | 2016-05-17 | 2022-11-23 | Boston Scientific Neuromodulation Corporation | Systems for anchoring a lead for neurostimulation of a target anatomy |
KR102555691B1 (ko) | 2016-06-30 | 2023-07-13 | 노보큐어 리미티드 | 신체에 대한 종양 치료장의 길이 방향 전달을 위한 어레이들 |
US20180008708A1 (en) | 2016-07-10 | 2018-01-11 | Novocure Limited | Synchronizing Tumor Cells to the G2/M Phase Using TTFields Combined with Taxane or Other Anti-Microtubule Agents |
DK3500334T3 (da) | 2016-08-18 | 2023-10-09 | Novocure Gmbh | Temperaturmåling i arrays til levering af ttfields |
US20180154142A1 (en) | 2016-12-05 | 2018-06-07 | Old Dominion University Research Foundation | Methods and devices for treatment of tumors with nano-pulse stimulation |
CN106823145A (zh) | 2017-03-24 | 2017-06-13 | 长沙普特斯科技有限公司 | 一种采用调幅电场治疗肿瘤的装置 |
PL421532A1 (pl) | 2017-05-08 | 2018-11-19 | Michalczyk Marta | System do leczenia nowotworów wewnątrzczaszkowych z wykorzystaniem implantu, generującego ciągłe, zmienne pole elektryczne oraz ultradźwięki, zasilanego metodą przezskórnego transferu energii |
US20190117969A1 (en) | 2017-10-23 | 2019-04-25 | Cardiac Pacemakers, Inc. | Medical devices for treatment of cancer with electric fields |
US20190117971A1 (en) | 2017-10-23 | 2019-04-25 | Cardiac Pacemakers, Inc. | Volume-filling leads for treatment of cancer with electric fields |
US20190117970A1 (en) | 2017-10-23 | 2019-04-25 | Cardiac Pacemakers, Inc. | Electric field shaping leads for treatment of cancer |
US11338135B2 (en) | 2017-10-23 | 2022-05-24 | Cardiac Pacemakers, Inc. | Medical devices for cancer therapy with electric field shaping elements |
US11071875B2 (en) | 2018-02-20 | 2021-07-27 | University Of Iowa Research Foundation | Therapeutic systems using magnetic and electric fields |
US20200009376A1 (en) | 2018-07-03 | 2020-01-09 | Edwin Chang | Using Alternating Electric Fields to Increase Cell Membrane Permeability |
WO2020219337A1 (en) | 2019-04-22 | 2020-10-29 | Boston Scientific Scimed, Inc. | Systems for administering electrical stimulation to treat cancer |
JP7382422B2 (ja) | 2019-04-22 | 2023-11-16 | ボストン サイエンティフィック サイムド,インコーポレイテッド | 癌の併用電気化学療法 |
JP2022530872A (ja) | 2019-04-22 | 2022-07-04 | ボストン サイエンティフィック サイムド,インコーポレイテッド | 癌治療のための電気刺激機器 |
EP4356955A2 (en) | 2019-04-23 | 2024-04-24 | Boston Scientific Scimed, Inc. | Electrodes for electrical stimulation to treat cancer |
US11607542B2 (en) | 2019-04-23 | 2023-03-21 | Boston Scientific Scimed, Inc. | Electrical stimulation for cancer treatment with internal and external electrodes |
CN113766950A (zh) | 2019-04-23 | 2021-12-07 | 波士顿科学国际有限公司 | 带有热治疗或热监测的电刺激 |
US20220241586A1 (en) | 2019-05-09 | 2022-08-04 | Incube Labs, Llc | Anchor system for retaining a device in tissue |
WO2021173509A1 (en) | 2020-02-24 | 2021-09-02 | Boston Scientific Scimed, Inc. | Systems and methods for treatment of pancreatic cancer |
US20220296907A1 (en) | 2021-03-22 | 2022-09-22 | Cardiac Pacemakers, Inc. | Rechargeable systems for delivering electrical stimulation therapy for cancer therapy |
-
2020
- 2020-04-22 CN CN202080030856.7A patent/CN113766950A/zh active Pending
- 2020-04-22 WO PCT/US2020/029277 patent/WO2020219521A1/en unknown
- 2020-04-22 US US16/855,448 patent/US11712561B2/en active Active
- 2020-04-22 JP JP2021562972A patent/JP7476231B2/ja active Active
- 2020-04-22 EP EP20724703.2A patent/EP3958960A1/en active Pending
-
2023
- 2023-07-27 US US18/227,021 patent/US20240024670A1/en active Pending
Patent Citations (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050004507A1 (en) | 2000-03-13 | 2005-01-06 | Oncostim. Inc. | Method and device for treating cancer with electrical therapy in conjunction with chemotherapeutic agents and radiation therapy |
US20050096584A1 (en) | 2003-10-29 | 2005-05-05 | Bozidar Ferek-Petric | Implantable electroporation therapy device and method for using same |
JP2011078804A (ja) | 2004-04-23 | 2011-04-21 | Novocure Ltd | 異なる周波数の電界による腫瘍等の治療 |
US20170231694A1 (en) | 2004-09-10 | 2017-08-17 | Boston Scientific Scimed, Inc. | Apparatus and method for treatment of in-stent restenosis |
US20100217356A1 (en) | 2006-08-21 | 2010-08-26 | Marom Bikson | Method to reduce heating at implantable medical devices including neuroprosthetic devices |
US20100261994A1 (en) | 2009-04-09 | 2010-10-14 | Rafael Davalos | Integration of very short electric pulses for minimally to noninvasive electroporation |
US20110224665A1 (en) | 2010-03-11 | 2011-09-15 | Peter Andrew Crosby | Modular stimulator for treatment of back pain, implantable rf ablation system and methods of use |
JP2013544133A (ja) | 2010-10-25 | 2013-12-12 | メドトロニック アーディアン ルクセンブルク ソシエテ ア レスポンサビリテ リミテ | 腎ニューロモジュレーションのためのマルチ電極アレイを有するカテーテル装置ならびに関連のシステムおよび方法 |
US20140350541A1 (en) | 2011-12-13 | 2014-11-27 | Lazure Scientific, Inc. | Control and delivery of electric fields via an electrode array |
JP2016523135A (ja) | 2013-06-05 | 2016-08-08 | メタベンション インコーポレイテッド | 標的神経線維の調節 |
JP2017518805A (ja) | 2014-05-12 | 2017-07-13 | バージニア テック インテレクチュアル プロパティース インコーポレイテッド | パルス電界を使用した細胞の細胞内効果の選択的調節 |
US20200061385A1 (en) | 2015-07-01 | 2020-02-27 | Btl Medical Technologies S.R.O. | Aesthetic method of biological structure treatment by magnetic field |
WO2019084021A1 (en) | 2017-10-23 | 2019-05-02 | Cardiac Pacemakers, Inc. | ELECTRIC FIELD CANCER TREATMENT DEVICES COMPRISING FEEDBACK MECHANISMS AND DIAGNOSTICS |
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US20200338346A1 (en) | 2020-10-29 |
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US20240024670A1 (en) | 2024-01-25 |
US11712561B2 (en) | 2023-08-01 |
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