JP7213528B2 - pressurized drug injector - Google Patents

Description

The present invention relates to a pressurized pharmaceutical injector with an injection port for cleaning fluid.

According to the announcement by the National Cancer Center Hospital in 2013, the total number of cancer patients in Japan is 862,452, which is extremely high, and treatment is being carried out all over the country. Currently, the three major cancer treatments are surgery (surgical treatment), drug therapy (chemotherapy), and radiotherapy. Depending on the cancer type, stage (progress), patient background, etc., one or more of the above treatment methods are selected for each patient under the guidance of a specialist doctor, and multidisciplinary treatment is given. .

Of these, chemotherapy uses anti-cancer drugs and has the effect of suppressing the proliferation of cancer cells and preventing recurrence and metastasis. Anticancer drugs can be treated with a single type of drug or with a combination of several types of drugs. Depending on the type of drug, it is administered orally, by intravenous drip, by subcutaneous injection, or directly into other organs. Therefore, the purpose and timing of implementation differ depending on the type of cancer, stage (progress of disease), lifestyle, and the like. The administration period is usually divided into several times over several weeks to several months.

In addition, colorectal cancer (ranked 2nd by site) and breast cancer (ranked 4th by site) are major types of cancer that are often treated with chemotherapy because of their good drug response and high treatment results. The main drug solution administration schedule for colorectal cancer chemotherapy is repeated intravenous administration for 46 to 48 hours per dose once every two weeks, and drug administration is performed using a portable pressurized drug infusion pump. often. In addition, breast cancer chemotherapy is also carried out as one course of continuous administration for 15 to 90 minutes each time for 21 to 28 days, mainly by intravenous drip.

When these drug solutions are continuously administered intravenously over a short period of time, patients experience (1) pain due to securing the blood vessel with an injection needle each time, and (2) the fact that they are connected to the infusion route during administration. (3) Intravenous injections use peripheral veins such as elbows or wrists, but those blood vessels are thin, and administration of high-concentration anticancer drugs there causes severe pain due to osmotic pressure. (4) In the case of intravenous injection, if the vein is thin or obstructed, repeated puncture of the injection needle may be required. To alleviate these problems, the tip of a resin tube, called a catheter, which is thinner than a blood vessel, is inserted into the supracentral vein, and a silicon septum (repeated Huber needle) is inserted into a metal or resin tank called a port. A CV port, which is connected to a device with a port-specific needle (target) and is implanted under the skin, has been developed and is widely used in patients undergoing anticancer drug treatment. When using the CV port, if the Huber needle is used and the drug solution is not to be administered, the needle can be removed to release the drip line.

In addition, current chemotherapy is carried out based on evidence from various clinical trials, and it has been proven that continuous administration of some anticancer agents improves therapeutic effects. Based on the results of these treatments, FOLFOX6/FOLFIRI therapy, which is a representative form of chemotherapy for colorectal cancer and is administered continuously for 46 to 48 hours, has become the global standard treatment. In addition, depending on the regimen, it may be administered continuously for 7 days, and the patient is forced to rest in hospital because he is connected to the drip route. Therefore, in recent years, a portable balloon-type drug injector has been developed, and by using it in combination with the above-mentioned CV port system, the patient is released from the drip route even while drug solution is being administered, so treatment can be performed outpatient or at home. Became.

In this anticancer drug administration system, a drug solution filling port called a CV port is surgically placed in the patient's body, such as the chest, upper arm or forearm, and the implanted CV port penetrates the patient's skin. A (portable) pressurized drug injector that pierces a Huber needle and is portable through the Huber needle (and associated tubing) is widely known.

When the drug solution injection from the CV port is completed, wash the drug solution remaining in the port and the catheter, and in order to prevent blockage inside the catheter due to thrombus formation due to reverse blood and changes in drug composition, etc., remove the cleaning solution from the Huber needle. (Physiological saline or heparinized saline) must be used to clean the inside of the CV port (hereinafter referred to as system cleaning).

BACKGROUND ART As a conventional portable pressurized drug injector used for administration of anticancer drugs, a medical liquid storage container as shown in Patent Document 1 is known. This medical liquid storage container is a pressurized pharmaceutical injector that pushes out the medical liquid out of the container by the force of contraction of the balloon by introducing the medical liquid into the balloon and expanding it.

However, in the invention described in Patent Document 1, when cleaning the system of the CV port, Huber needle and tube after administering the drug solution, the tube connector of the pressurized pharmaceutical injector is removed from the tube connector of the Huber needle and prepared separately. It is necessary to connect a syringe containing saline or heparinized saline (hereinafter referred to as a syringe containing washing solution) to the tube connector of the Huber needle for washing. This operation is not only troublesome for the patient or user, but it is also known that the operation of replacing the connection of the route increases the risk of leakage of the drug solution or cleaning solution and infection. In particular, if the anticancer drug leaks out of the route and is exposed to the human body, there is a risk of causing serious complications such as injury or damage to the human body. Means for preventing this have conventionally been implemented in an uncertain and complicated manner, such as wearing gloves so as not to be exposed to the leaked chemicals, and carefully handling the members.

After the drug injection from the portable pressurized drug injector containing the anticancer drug is completed, medical staff, patients, and their families (hereafter referred to as users) need to clean the system as described above. In general, remove the connection between the pressurized pharmaceutical injector and Huber needle and connect a syringe containing cleaning fluid to clean the system, or remove the unevenness attached to the route of the pressurized pharmaceutical injector and Huber needle. System cleaning is performed by connecting a syringe containing cleaning fluid to a connectable connector (three-way stopcock, Y connector, etc.). It can be said that this operation is always exposed to anticancer drug exposure, droplets, and causes of infection in order to open and connect the tube filled with anticancer drugs.

JP 2015-181822 A

Therefore, it is an object of the present invention to provide a portable pressurized pharmaceutical injector for preventing leakage of the chemical or cleaning solution, exposure to the human body, and infection during system cleaning using the cleaning solution.

In order to achieve the above object, the present invention provides a pressurized pharmaceutical injector equipped with a system cleaning function, comprising a medical fluid filling port for filling a medical fluid into a reservoir, a balloon storing a medical fluid and having a pressure capable of discharging the medical fluid, and the like. (including a tank that can be filled with a drug and has a pressurization function), a flow rate control tube that adjusts the flow rate of the drug that is discharged by pressurization from a balloon, etc. , an infusion filter that prevents contamination by air and bacteria, and a container that contains the chemical injection port of the system cleaning port.
The container has respective openings for a drug solution filling port, a system cleaning solution inlet, and a drug solution discharge port. This pressurized pharmaceutical injector is characterized in that the washing port is moved to the outside through communication means such as a tube.

In the case of the pressurized pharmaceutical injector with this configuration, the system cleaning port is installed as a single unit inside, so when cleaning the stem, which was previously performed by the user at the end of drug administration, the connector equipped on the tube, etc. It is not necessary to remove and replace the syringe containing the washing solution. Therefore, when the user cleans the system such as the CV port, the chemical solution or cleaning solution will not leak outside, and the user, all the people who handle this product, and the surrounding people can be prevented from being exposed to the chemical solution. Therefore, it can be said that the use is convenient and safe for patients or users in that careful handling operations for preventing drug exposure and excessive precautions and troubles for leakage are not required.

In addition, according to the pressurized pharmaceutical injector of this configuration, the chemical solution filling port for injecting the chemical solution and the system cleaning port injection port are all arranged inside the container, so even when the chemical solution and cleaning solution are filled and injected, It is possible to prevent leakage and exposure of chemicals.

The drug solution filling port and the system cleaning port inlet have a connector function (screw hole) that fits with the tip of a syringe for medical equipment in order to introduce the drug solution and cleaning solution.

The medical device connected to the injection port of the drug solution filling/system cleaning port of the pressurized drug injector of this configuration can be fixed by screw fitting, and the injection pressure is generated between the syringe and each filling port when the drug solution is injected. It is possible to suppress the stress that tends to separate them due to the repulsive action, so that the operation can be performed safely and easily without worry.

Preferably, the system wash port inlet opening of the container is sealed by a removable sealing member.

One of the most important things is to prevent contamination (introduction of infection-causing bacteria, etc. into the body through operation) that occurs during system cleaning operations.
With the pressurized pharmaceutical injector of this configuration, the system cleaning port injection port and its opening are sealed with a clean sealing member until just before the system cleaning operation, maintaining a sterile state and preventing contamination due to connection operation. This allows patient-safe system cleaning operations.

With the pressurized pharmaceutical injector of this configuration, it is possible to adjust the flow rate of the medicine according to the purpose of use, regardless of the nature of the medicine and the patient. applicable. In addition, the flow rate is controlled between the balloon and the drug discharge port, and the system cleaning port injection port is attached downstream from the flow control tube. The internal pressure rises, and the downstream side is connected to the vein via the CV port placed in the patient, so the pressure difference prevents the cleaning fluid from flowing upstream of the flush port, and the cleaning fluid flows downstream to clean the system. becomes possible.

It is desirable that an infusion filter for suppressing the passage of particles and air below a predetermined diameter be provided immediately before the flow control tube. The infusion filter comprises hydrophobic and hydrophilic membranes.

With the pressurized pharmaceutical injector of this configuration, an infusion filter is provided in the flow path through which the drug passes, so there is no need to prepare a separate infusion filter, making it possible for patients to administer medication more easily, safely, and with good portability. Become.

A tube is used as a communication means for each member such as the drug solution outlet, the infusion filter, the flow control tube, and the system cleaning port, which are arranged in the container. Preferably, a substantially cylindrical tube winding portion is provided.
This allows even the use of long tubes to be placed within the container, making it possible to provide a compact pressurized drug injector.

According to the pressurized pharmaceutical injector of the present invention, when the user cleans the system, the chemical solution or cleaning solution does not leak to the outside, preventing exposure to the user and surrounding people, and preventing the chemical solution or cleaning solution from leaking out. Leakage and exposure can also be prevented when filling pressurized drug injectors. Therefore, it is beneficial for the user to wear gloves to prevent exposure and reduce the mental burden of careful operation.

In addition, with the pressurized pharmaceutical injector of this configuration, when introducing a medical solution or cleaning solution, all the medical solution injection ports can be fixed by screwing into the medical syringe. The separation that occurs can be suppressed, and the operation can be performed safely and easily.

Furthermore, according to the pressurized pharmaceutical injector of the present invention, the flexible and strong resin material prevents direct impact or stress from being applied directly to the balloon filled with the medical solution due to an erroneous operation such as dropping by the user during administration of the medical solution. container absorbs shock. In the unlikely event that the balloon breaks and the liquid leaks, the liquid medicine does not leak out of the container because the container uses a hydrophobic air filter. This can prevent exposure to the user and surrounding people. In addition, even when dropped, it is possible to prevent damage by not directly impacting the internal chemical filling port and system cleaning port.

FIG. 4 shows an example of a schematic diagram of a flow path of a drug solution in the pressurized pharmaceutical injector of the present invention. FIG. 4 shows a schematic diagram of another flow path of the drug solution in the pressurized pharmaceutical injector of the present invention. FIG. 11 shows still another schematic diagram of the flow path of the drug solution in the pressurized pharmaceutical injector of the present invention. 1 shows a perspective view of one example of a pressurized pharmaceutical injector of the present invention; FIG. The perspective view seen from the back side of FIG. 4 is shown. (a) is a cross-sectional perspective view of one of the pressurized pharmaceutical injectors cut along the AA' cross section in FIG. 4, and (b) is the other pressurized pharmaceutical injector cut along the AA' cross section of FIG. 1 shows a cross-sectional perspective view of the .

Hereinafter, the pressurized pharmaceutical injector of the present invention will be described with reference to the drawings.
FIGS. 1, 2 and 3 are schematic diagrams showing flow paths of a chemical liquid and a cleaning liquid in a specific configuration example of the pressurized medical injector of the present invention (see FIGS. 4 to 6). A pressurized pharmaceutical injector will be described in detail with reference to the schematic diagrams of FIGS. 1, 2 and 3. FIG. Each member name will be described in detail after the description of the flow path.

FIGS. 1(a), (b), FIGS. 2(a), (d) and FIG. 3 show examples of flow paths of the pressurized pharmaceutical injector 1 which is an embodiment of the present invention shown in FIGS. 4 to 6. ing. According to the flow path of FIG. 1(a), after filling the balloon 50 with the drug solution from the drug solution filling port of the pressurized medical injector 1, the drug solution is discharged from the drug solution outlet 8d of the reservoir 8 through the first tube (not shown). Move to the infusion filter 14, move from the infusion filter 14 to the flow control tube 11 through the second tube (not shown), and introduce the washing liquid from the flow control tube 11 through the third tube (not shown). to the system wash port 12, which has a wash fluid inlet (not shown) for the patient, and through a fourth tube (not shown) to the patient: CV port. At this time, if a flow rate control tube is used as a substitute for the flow rate control tube 11, it is possible to use the flow rate control tube for the second tube to the third tube.

The flow rate control tube is a tube that adjusts the flow rate by the frictional properties of the inner surface of the tube, and by arbitrarily adjusting the length, it is possible to arbitrarily adjust the administration rate of the drug.
On the other hand, when the flow control tube 11 is used, there is no need to consider the handling of the tube, and the members can be stably arranged, so it is possible to reduce wasted space. It becomes vessel 1.

The pressurized pharmaceutical injector 1 of the present invention has a configuration in which the tube extending from the chemical outlet 8d to the downstream of the system cleaning port 12 in the flow path described above is provided as one unit. , There is no need for a route switching operation for injecting cleaning fluid, such as removing this pressurized pharmaceutical injector 1 and the Huber needle, or using another connection system. Prevention is possible.

Next, in the flow path of FIG. 1(b), the infusion filter 14 is integrated with the drug solution outlet 8d. In this case, the first tube becomes unnecessary, and the second tube directly communicates from the infusion filter 14 to the flow control tube 11, and further moves from the fourth tube to the patient via the CV port. With this configuration, the unit size and weight of the pressurized pharmaceutical injector 1 are small, and therefore the portability is excellent.
In the flow channel of FIG. 1(b), as in the flow channel of FIG. It is also possible to deal with

A configuration without the infusion filter 14 as shown in FIG. 2(a) may be used. With this configuration, the unit size of the pressurized pharmaceutical injector 1 is small and the weight is small, so the portability is excellent. In the flow path of FIG. 2(a), from the chemical outlet 8d, it moves to the flow control pipe 11 through the first tube, and from the flow control pipe 11 through the third tube, the cleaning liquid inlet for introducing the cleaning liquid is provided. system wash port 12 with a fourth tube through the CV port to the patient. At this time, if a flow control tube is used as a substitute for the flow control tube 11, it is possible to use the flow control tube from the first tube to the third tube.

In the route shown in FIG. 2(b), the drug solution outlet 8d, the infusion filter 14 and the flow rate control tube 11 are integrated. The first and second tubes are no longer necessary, and the third tube directly communicates with the system cleaning port 12, and further moves to the patient: CV port via the fourth tube. With this configuration, the unit size and weight of the pressurized pharmaceutical injector 1 are reduced, so that portability is excellent.

3, the chemical outlet 8d, the infusion filter 14, the flow control tube 11, and the system cleaning port 12 are integrated. The first tube, second tube, and third tube described above become unnecessary, and the patient moves to the CV port via the fourth tube. With this configuration, the unit size and weight of the pressurized pharmaceutical injector 1 are reduced, which is advantageous in that it is excellent in portability.

1(b), 2(a), 2(b), and 3. Even in the present pressurized pharmaceutical injector 1 that employs the flow paths shown in FIGS. It can be said that at least the tube from the chemical solution filling port to the chemical solution discharge port 8d to the downstream of the system cleaning port 12 is provided as one unit.

Next, a specific configuration example of the pressurized pharmaceutical injector 1 of the present invention described above will be described with reference to FIGS. 4 to 6. FIG.

4 and 5 are perspective views showing an embodiment of the pressurized pharmaceutical injector 1 of the present invention. FIG. 5 shows a rear view of FIG. 4 (back side of the paper surface). The pressurized pharmaceutical injector 1 of the present invention shown in FIGS. 2 is composed of a drug solution connecting tube 20 and a balloon 50 shown in FIG.

The exterior case 2 has a rectangular z-direction cross section with r-shaped corners, and is tapered from the lower end to the bottom. Therefore, as a whole, it has a shape that has few corners and is safe and does not get caught when it is put in a patient's pocket or the like. The upper cover 4 has a rectangular z-direction cross-section with r-shaped corners like the outer case 2 , and has a top plate with an open bottom. Between the outer case 2 and the upper cover 4, a substantially flat top plate 6, which is the upper portion of the outer case 2, is arranged. are provided with gaps (spaces).

The container consisting of the exterior case 2 and the upper cover 4 is made of a light material such as resin and is excellent in portability. In addition, elastic materials are used in the examples of FIGS. 4 to 6 in order to prevent breakage and damage due to impact such as dropping and external stress.

On the top plate 6, the tube winding portion 10, the reservoir 8, and the system cleaning port 12 are arranged substantially in series in the longitudinal direction of the top plate 6. The top plate of the cover 4 is arranged so as not to interfere with each other. Approximately circular openings 4a and 4b are provided in the top plate of the upper cover 4, and the chemical solution filling port 8a of the reservoir 8 and the cleaning solution introduction part 12a of the system cleaning port 12 are used when introducing the chemical solution and the cleaning solution. can be fluidly connected to a medical syringe. A substantially circular opening 4c is provided on the side of the upper cover 4 in the vicinity of the system cleaning port 12 for passing a tube for discharging the chemical solution or cleaning solution to the outside.

With the above configuration, the pressurized pharmaceutical injector 1 can be easily stored in a pouch or a bag, and can be administered while in a pocket of clothing, making it easy for patients to carry. Although the details will be described later, in this pressurized pharmaceutical injector 1, since the system cleaning port for introducing the cleaning liquid is in the pressurized pharmaceutical injector 1, it is necessary to perform the route switching operation of the chemical liquid to be injected into the system cleaning and the cleaning liquid. Therefore, cleaning can be performed while avoiding exposure and infection due to unexpected liquid leakage.

The reservoir 8 is integrally formed with the liquid medicine connecting pipe 20 shown in FIG. A liquid medicine filling port 8a is arranged on the upper side of the top plate 6 of the reservoir 8, and the upper cover 2 is formed with an opening 4a for connecting with the liquid medicine filling port 8a.

On the other hand, a drug solution connecting pipe 20 integrally formed with the lower reservoir 8 of the top plate 6 is arranged in the space between the exterior case 2 and the top plate 6, and a balloon 50 is attached so as to cover it.
As for the material, it is preferable to use a resin having a certain degree of elasticity in order to prevent easy damage when dropped. When the drug solution is filled, the drug solution (not shown) is supplied from a syringe or the like (not shown) by a medical staff's hand or by mechanical control, through the opening 4a of the upper cover 4 and the drug solution filling port 8a, and into the drug solution connection pipe 20 shown in FIG. injected into. Although not shown, a check valve 8c is arranged between the chemical solution filling port 8a and the reservoir strut, so there is no backflow to the chemical solution filling port.

Further, although not shown, another example of the drug solution filling port 8 a has a screw hole that fits with the tip of a medical syringe for introducing the drug solution into the balloon 50 . The tip of a medical syringe having a screw-type lock is fixed to the medical solution filling port 8a by screw fitting while being rotated, so that the effect of the reaction generated by the resistance of the medical solution between the medical solution filling port 8a and the medical syringe when the medical solution is filled. can be suppressed, separation can be prevented, and stable chemical filling is possible.

The opening 4a of the upper cover 4 is provided with a detachable cap (not shown) by, for example, screw fitting. By removing the cap when introducing the drug and attaching the cap before and after introducing the drug, contamination of the opening 4a is prevented before the liquid medicine filling operation and contamination (contamination) of the inside of the pressurized drug injector 1 during liquid medicine filling is prevented. However, when the medical syringe or the like is removed, the drug remaining in the opening can be sealed. The cap is preferably attached to the exterior case 2 or the upper cover 2 with a strap or the like so as not to be lost during use.

The structure of the reservoir 8 will now be further described with reference to FIG. Fig. 6 shows a view of Fig. 4 cut along AA' cross section (xz cross section), Fig. 6(a) shows a view from the front side of Fig. 4, and Fig. 6(b) shows a view from the back side of the paper. ing. As shown in FIG. 6, the reservoir 8 is integrally formed with a chemical filling port 8a, a receiving portion 8b, a check valve 8c, a chemical connecting pipe 20 , and a chemical discharging port 8d from the upper side. A medical staff connects the tip of a medical syringe or the like to the drug solution filling port 8a, applies a positive pressure to pass the drug solution through the check valve 8c, and fills the balloon 50 through the drug solution connecting pipe 20 with the balloon. The check valve 8c completely prevents the drug solution filled in the balloon 50 from backflowing into the drug solution filling port 8a, so that the drug can be delivered to the drug solution discharge port 8d .

The balloon 50 is arranged between the exterior case 2 and the top plate 6, covers the drug solution connecting tube 20 of the reservoir 8, and fixes the filled drug so that it does not leak.
The balloon 50 is made of resinous rubber such as silicon rubber, which has chemical resistance, pressure resistance, and elasticity. When the balloon 50 is filled with a medical solution, it is deformed under pressure, and the force acting to restore the deformation under pressure can push the medical solution upward. As a result, the chemical liquid is sent out through the chemical liquid connecting pipe 20 to the chemical liquid discharge port 8d .

A dotted line in FIG. 6 indicates a state in which the balloon 50 is inflated by being filled with the drug solution. The balloon 50 expands within the spatial range of the exterior case 2, and when it shrinks to its original size, it pushes out the enclosed drug solution upward.

In addition to the balloon, the pressure deformation means may use a driving method such as a motor, air pressure, or a spring.

A first tube (not shown) is connected to the drug solution outlet 8d , which is connected to the injection port 14a of the infusion filter 14, and a flow rate control tube (not shown) is connected to the outlet 14b of the infusion filter 14. It is Since the flow rate control tube requires a length of 5 to 10 cm, it is wound around the substantially cylindrical tube winding part 10 so as not to bend the tube, connected to the port inlet 12b of the system cleaning port 12, and connected to the outlet of the system cleaning port 12. A fourth tube is connected to 12c and exits the container through an opening 4C of the upper cover 4. As shown in FIG.

The tube winding part 10 is preferably made of elastic lightweight resin so that the flow control tube can easily be wound and the tube is not crushed or broken, and the outer circumference is provided with a helically rounded groove.

The infusion filter 14 is arranged near the longitudinal inner side surface of the upper cover 4 . A general shape is adopted, and FIGS. 4 to 6 show a substantially circular shape. The infusion filter 14 filters the medicinal solution, and if the filled medicinal solution contains foreign matter, large particles, or air, it can be used to prevent contamination of the patient and clogging of the flow control tube 11 and the flow control tube. preferably.

As another example (not shown) of the configuration from the chemical liquid outlet 8d to the port inlet 12b, there is also a configuration in which the chemical liquid outlet 8d and the port inlet 12b are communicated with each other through the flow control pipe 11. FIG. According to this configuration, it is possible to directly connect between the liquid discharge port 8d and the port inlet 12b to the flow rate control pipe 11 without using a tube. The overall size of the pressure medication injector 1 can be further reduced. Here, the flow rate control pipe means a pipe capable of controlling the flow rate by inserting a resistance device such as unevenness or a filter into the pipe. Further, if the infusion filter 14 is provided in the flow control tube, the size of the pressurized pharmaceutical injector 1 can be made more compact while preventing foreign matter and large particle size particles from entering the patient.

As another example (not shown), the opening 4b of the upper cover 4 may be provided with a removable sealing member. The sealing member seals from the outside so as to cover the opening 4b, and by removing the sealing member when introducing the cleaning liquid, it is possible to see the cleaning liquid introduction section 12a through the opening 4b and the opening 4b. As a result, contamination around the cleaning liquid introduction part 12a can be prevented, and the flush port 12 can be kept clean until the system cleaning. In addition to the opening 4b, the cleaning liquid introduction section 12a, the opening 4b, and the cleaning liquid introduction section 12a may be sealed with a sealing member. In addition to the sealing member, it is also conceivable to adopt the above-described cap member as necessary.

In addition, in the system cleaning port 12, similarly to the reservoir 8 described above, the upper part of the cleaning liquid introducing portion 12a at the upper end of the system cleaning port 12 and the opening 4b of the top plate of the upper cover 4 are arranged apart from each other. With this configuration, even if an erroneous operation occurs when introducing the chemical or cleaning liquid, or if the opening 4b faces the ground, it is possible to prevent the chemical or cleaning liquid from leaking out of the pressurized medical injector 1. is.

Furthermore, the upper cover 4 also increases the effect of mitigating direct impacts on the reservoir 8 and the system wash port 12 .

Although the pressurized pharmaceutical injector 1 of the present invention has been described above with reference to FIGS. For example, the first tube may be connected to the flow control tube 11 and eliminated as the second tube by removing the filter 14 to improve portability. Also, the filter 14 may be provided integrally with the reservoir 8 . In addition, the shape of the pressurized pharmaceutical injector 1 as a whole can be made flatter or elongated in accordance with the place where it is placed.

As still another example, the cleaning liquid introduction part 12a of the system cleaning port 12 is arranged in, for example, the exterior case 2, and an opening is provided in the exterior case 2 so that the cleaning liquid introduction part 12a and the chemical solution filling port 8a are separated from each other. By arranging it in a more convenient place, it is possible to make it lighter and more compact. In addition, in order to maintain the sanitary condition of the cleaning fluid introduction part 12a of the system cleaning port 12, a method of arranging the system cleaning port 12 including the cleaning fluid introduction part 12a in a substantially closed space is also conceivable.

With conventional pressurized pharmaceutical injectors, when cleaning the system, it is necessary to switch tube connections, etc., to inject cleaning fluid, which poses the risk of exposure to chemicals and infection. As described above, the pressurized pharmaceutical injector 1 of the present invention is provided with the system cleaning port 12 in the substantially closed space formed by the exterior case 2 and the upper cover 4. With this configuration, tube connection, etc. There is no need to switch between them, and it is possible to fill the chemical solution and inject the washing solution as one unit that includes all the tubes, filters, and the like. The tube winding section 10 enables a tube of any length to be densely arranged in a fixed space without damage.

The pressurized pharmaceutical injector 1 of the present invention has been described above, but the arrangement shape and size of the members are suitable for use as medicines and medical equipment, and are within a general range to respond to medical care that is evolving day by day. It goes without saying that modifications can be made in

2 Exterior case 4 Top cover 6 Top plate 8 Reservoir 8d Chemical solution outlet
10 tube wrap 12 system wash port 14 infusion filter
20 chemical connecting pipe
50 balloon

Claims (5)

A pressurized pharmaceutical injector with system cleaning, comprising:
a reservoir having a chemical inlet and a chemical outlet;
pressure deformation means communicating with the reservoir, the pressure deformation means being pressurized and deformed by the filling of the chemical solution from the chemical solution filling port, and pushing out the chemical solution from the chemical solution discharge port by the force of the pressure deformation returning; ,
a flow control tube that adjusts the flow rate of the chemical solution by resistance ;
a system wash port communicating with the flow control tube downstream of the flow control tube and having a wash fluid inlet for injecting a wash fluid and an outlet ;
a case containing the reservoir, the pressure deformation means, the flow control pipe, and the system cleaning port ;
with
The case has openings in the vicinity of the chemical filling port, the discharge port, and the cleaning liquid injection port,
The chemical solution injected from the chemical solution filling port is filled in the pressure deformation means to pressurize and deform the pressure deformation means, and is pushed out from the chemical solution discharge port by the pressure that causes the pressure deformation to return ,
The flow rate of the drug solution is adjusted by the flow control tube, and the drug with the adjusted flow rate passes through the system cleaning port and moves to the outside of the pressurized pharmaceutical injector from the outlet. Pharmaceutical injector. 2. The pressurized pharmaceutical injector according to claim 1, wherein the opening of the case near the cleaning liquid inlet is spaced apart from the top of the cleaning liquid inlet. 3. The pressurized pharmaceutical product according to claim 1 or 2 , wherein the chemical solution filling port and the cleaning solution inlet have screw holes inside thereof for fitting with the tip of a syringe for introducing the chemical solution and the cleaning solution. injector. 4. The pressurized type according to any one of claims 1 to 3, wherein an opening of the case near the cleaning liquid inlet is sealed by a removable sealing member to ensure sterilization. pharmaceutical injector The pressurized type according to any one of claims 1 to 4, wherein a filter that suppresses passage of particles having a predetermined diameter or more is provided between the chemical outlet and the flow control pipe. Pharmaceutical injector.

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