JP6678097B2 - Instantaneous heart rate evaluation device, method and program - Google Patents

Description

  Embodiments of the present invention relate to an instantaneous heart rate evaluation device, method, and program for evaluating characteristics of instantaneous heart rate, which is biological information of a subject.

  There are two types of autonomic nerves: sympathetic nerves and vagus nerves. The sympathetic nerve and vagus nerve are widely distributed in various organs and the like, and control involuntary physical functions such as circulation and metabolism. In many cases, it is said that the sympathetic nerve and the vagus nerve antagonize one organ.

  It is known that sympathetic nervous activity, which is one of the autonomic nervous activities, is enhanced by stress stimulation such as mental arithmetic load.

  On the other hand, vagal activity, which is another autonomic nervous activity, is often understood as being equivalent to parasympathetic nervous activity, because the vagus nerve mainly carries sub-exchangeable nervous activity in each organ. Note that the vagus nerve is strictly the name of the Xth nerve, which is one of the cranial nerves, and refers to all the nerves from the brain to each organ. For this reason, the parasympathetic nerve activity in the target organ may be indicated by adding the name of the target organ, such as the cardiac vagus nerve.

  One of the organs governed by the autonomic nerve is the heart. It is said that the heart is antagonistically controlled by the sympathetic nerve and the vagus nerve, and reflects a static balance between sympathetic nerve activity and vagus nerve activity (for example, see Non-Patent Document 3).

  FIG. 4 is a diagram illustrating an example of the instantaneous heart rate (RRI). In particular, as shown in FIG. 4, the fluctuation of the instantaneous heartbeat (RRI: RR interval), which is the interval between two R waves adjacent in time series (hereinafter, sometimes simply referred to as adjacent), is caused by sympathetic nerve activity and vagus nerve. It is known to change with both activities. The R wave is one of electrocardiographic waveforms obtained by electrocardiogram measurement and reflects the depolarizing activity of the heart (for example, see Non-Patent Document 4).

  One of the means for measuring an electrocardiogram is a wearable device such as a Holter electrocardiograph. Electrocardiograms obtained by using these devices have abnormal electrodes due to electrode abnormalities such as deformation and displacement of electrodes, or measurement abnormalities due to various factors such as body movement, sweating, and static electricity (for example, see Non-Patent Document 5). FIG. 5 is a diagram illustrating an example of a measurement abnormality in an electrocardiogram. This measurement abnormality can be confirmed in the electrocardiogram in the form of noise (W1) and artifact (W2) as shown in FIG.

  Among the measurement abnormalities, the waveform observed as an artifact is similar to the R wave, and one or more waveforms are continuously observed. For this reason, an algorithm for analyzing an electrocardiogram and extracting an R wave may erroneously determine that an artifact is an R wave and extract the artifact (hereinafter, such a waveform is referred to as a measurement abnormal R wave). The abnormal measurement R-wave does not reflect the heart's depolarizing activity at all due to its mechanism of occurrence. Therefore, when at least one of the R waves constituting the instantaneous heartbeat is a measurement abnormal Rwave, it can be said that the instantaneous heartbeat is incorrect.

  As examples of the instantaneous heartbeat visualization method, a graph (first conventional method) shown in FIG. 6 (for example, see Non-Patent Document 1) and a Lorentz plot (second conventional method) shown in FIG. 7 (for example, Non-Patent Document 2) Reference). These visualization methods are used for grasping changes in instantaneous heart rate.

Science of stress and autonomic nervous system (confirmed October 13, 2016), http://hclab.sakura.ne.jp/stress_novice_LFHF.html, Yusuke Tsuji, A study on the psychological burden evaluation of the cared person in the downward movement of the care lift, Mie University Graduate School of Engineering 2013 Master's thesis, 2014 Hiroshi Inoue, Cardiovascular Disease and Autonomic Nervous Function 2nd Edition, Medical Shoin, 2001 Jun Okude, you know! Easy point electrocardiogram 2nd edition, Medical Shoin, 2011 Nihon Kohden, mechanism of noise contamination and countermeasures: points for recording a clean ECG-Holter ECG version-(October 6, 2016), http://www.nihonkohden.co.jp/iryo/point/holter/ mechanism.html Shigeyuki Watanabe et al., How to Read ECG Perfect Manual, Yodosha, 2006

  In the first and second conventional methods, all the instantaneous heartbeats to be drawn are expressed in the same manner. For this reason, it is not possible to distinguish between (1) the instantaneously measured instantaneous heartbeat and (2) the instantaneous heartbeat in which at least one of the R waves constituting the instantaneous heartbeat is a measurement abnormal Rwave.

  The present invention has been made in view of the above circumstances, and an object of the present invention is to provide an instantaneous heart rate evaluation device, an instantaneous heart rate evaluation method, and a program which can realize visualization of characteristics of an instantaneous heart rate measured during a certain period. It is to be.

In order to achieve the above object, a first aspect of the instantaneous heart rate evaluating apparatus according to the embodiment of the present invention is to convert an R-wave of an electrocardiogram based on a signal output from an electrocardiogram measuring means for measuring a subject's electrocardiogram. Extracting means for extracting, calculating means for calculating at least two instantaneous heartbeats, which are intervals between two R waves adjacent in time series, extracted by the extracting means, and two adjacent heartbeats extracted by the extracting means. Evaluating means for evaluating the measurement state of the instantaneous heartbeat calculated by the calculation means, which is the interval of the R wave, according to the type of each measurement state of the R wave, and for the instantaneous heartbeat evaluated by the evaluation means, Color information determining means for determining color information according to the type of the evaluation, wherein the measurement state of the R wave is a first measurement state of the R wave, a second measurement state of the R wave, and Third measurement of R wave The first measurement state of the R-wave is an abnormal measurement state in which the potential of the R-wave satisfies the condition, and the second measurement state of the R-wave is that the potential of the R-wave is While the magnitude does not satisfy the condition, the fluctuation of the base line of the potential of the R wave is noise having a magnitude satisfying the condition, and the third measurement state of the R wave does not correspond to the abnormal measurement state and the noise. Provide a device that is in a normal measurement state.

In a second aspect of the instantaneous heart rate evaluation device having the above configuration, in the first aspect, the measurement state of the instantaneous heartbeat is a first measurement state of the instantaneous heartbeat, a second measurement state of the instantaneous heartbeat, A first measurement state of the instantaneous heartbeat including a third measurement state of the instantaneous heartbeat, a fourth measurement state of the instantaneous heartbeat, a fifth measurement state of the instantaneous heartbeat, and a sixth measurement state of the instantaneous heartbeat The state indicates that the measurement state of one of the R waves constituting the instantaneous heartbeat and the other measurement state of the other R wave are the normal measurement state, and the second measurement state of the instantaneous heartbeat indicates that the instantaneous heartbeat constitutes the instantaneous heartbeat. Indicates that the measurement state of the R wave is the normal measurement state and the other measurement state is the noise, and the third measurement state of the instantaneous heartbeat is one and the other R wave constituting the instantaneous heartbeat The measurement state of all The fourth measurement state of the instantaneous heartbeat indicates that the measurement state of one of the R waves constituting the instantaneous heartbeat is the normal measurement state and the other measurement state is the abnormal measurement state. The fifth measurement state of the instantaneous heartbeat indicates that the measurement state of one of the R waves constituting the instantaneous heartbeat is the noise and the other measurement state is the abnormal measurement state. The sixth measurement state provides an apparatus that indicates that the measurement states of one and the other R-waves constituting the instantaneous heartbeat are both abnormal measurement states.

In a third aspect of the instantaneous heart rate evaluation device having the above configuration, in the second aspect, the evaluation means may be configured to determine whether the measurement state of the instantaneous heartbeat is a measurement state of a preceding R wave in a time series constituting the instantaneous heartbeat. The color information determining means determines the color information based on the type of evaluation of the instantaneous heartbeat by the evaluating means and the order evaluated by the evaluating means. Provide equipment.

According to a fourth aspect of the instantaneous heart rate evaluation device having the above configuration, in the third aspect, the evaluation means evaluates a length of time of the instantaneous heartbeat, and the color information determination means determines the instantaneous heartbeat by the evaluation means. And an apparatus for determining the color information for determining the color information based on the type of evaluation, the order evaluated by the evaluation means, and the length of the instantaneous heartbeat time evaluated by the evaluation means.

An aspect of the instantaneous heart rate evaluation method according to the embodiment of the present invention is a method applied to an apparatus, in which an R-wave of an electrocardiogram is extracted based on a signal output from an electrocardiogram measuring unit that measures a subject's electrocardiogram. And calculating at least two instantaneous heartbeats, which are intervals between two extracted R-waves that are adjacent in time series, and according to the type of the measurement state of each of the extracted two adjacent R-waves, Estimate the measurement state of the calculated instantaneous heartbeat, which is the interval of the R-wave, determine color information corresponding to the type of the evaluation for the evaluated instantaneous heartbeat, and the measurement state of the R-wave is The first measurement state of the R wave includes a first measurement state of the R wave, a second measurement state of the R wave, and a third measurement state of the R wave. An abnormal measurement state that satisfies the condition, and the second measurement of the R wave The state is noise in which the potential of the R-wave does not satisfy the condition while the fluctuation of the baseline of the R-wave potential satisfies the condition, and the third measurement state of the R-wave is A method is provided for an abnormal measurement state and a normal measurement state that does not correspond to the noise .

  An aspect of the instantaneous heart rate evaluation processing program according to the embodiment of the present invention is a program used for a computer that operates as a part of the instantaneous heart rate evaluation apparatus according to the first aspect, wherein the computer includes the extraction unit, the calculation unit, A program for functioning as the evaluation unit and the color information determination unit is provided.

  ADVANTAGE OF THE INVENTION According to this invention, it becomes possible to implement | achieve the visualization of the characteristic of the instantaneous heartbeat measured in a certain period.

FIG. 1 is a diagram illustrating a configuration example of an instantaneous heart rate visualization device according to an embodiment of the present invention. 5 is a flowchart illustrating an example of a processing procedure performed by the instantaneous heart rate visualization device according to the embodiment of the present invention. The figure which shows an example of the relationship between the absolute value of the potential amplitude of QRS group, and the potential of R wave. The figure which shows an example of an instantaneous heartbeat (RRI). The figure which shows an example of the measurement abnormality in an electrocardiogram. The figure which shows an example of an instantaneous heartbeat. The figure which shows an example of an instantaneous heartbeat.

Hereinafter, embodiments of the present invention will be described with reference to the drawings.
In one embodiment, the patterning of the instantaneous heartbeat is performed based on at least one of the information of the R wave or the time information of the instantaneous heartbeat constituting the instantaneous heartbeat, and the color code corresponding to the instantaneous heartbeat is determined according to the pattern. Note that the pattern division includes at least one of the following information (a), (b), and (c).

(A) Combination information of measurement states of two R waves constituting instantaneous heartbeat (information indicating combination of measurement states of two R waves constituting instantaneous heartbeat)
(B) Order information of the measurement states of the two R-waves constituting the instantaneous heartbeat (information indicating the order of the measurement states of the two R-waves constituting the instantaneous heartbeat)
(C) Time information of instantaneous heartbeat (information indicating the time of instantaneous heartbeat)
(Constitution)
FIG. 1 is a diagram illustrating a configuration example of an instantaneous heartbeat visualization device according to an embodiment of the present invention. 1 includes an electrocardiogram measuring unit 11 and an instantaneous heart rate visualizing unit (instantaneous heart rate evaluating unit) 12. As an example, in the instantaneous heart rate visualization device 10, the electrocardiogram measurement unit 11 is a wearable device that can be worn on a subject (user), and the instantaneous heart rate visualization unit 12 is a computer device such as a smartphone, a tablet terminal, and a personal computer (PC). It is realized by the system. For example, the computer device includes a processor such as a CPU (Central Processing Unit), a memory connected to the processor, and a communication interface for communicating (for example, wirelessly) with the electrocardiogram measurement unit 11. In addition, the realization form of the instantaneous heartbeat visualization device 10 is not limited to this example. For example, the instantaneous heart rate visualization device 10 may be realized as one device. In addition, the electrocardiogram measurement unit 11 may be provided outside the instantaneous heart rate visualization device 10. In other words, the instantaneous heart rate visualization device 10 may acquire the result of measuring the subject's electrocardiogram from an external electrocardiogram measurement device corresponding to the electrocardiogram measurement unit 11.

  The difference between the embodiment and the prior art is that each of the instantaneous heartbeats of the subject is based on at least one of (1) information on the R wave constituting the instantaneous heartbeat or (2) time information on the instantaneous heartbeat. , A corresponding color code is determined.

  The electrocardiogram measurement unit 11 measures the subject's electrocardiogram, and sends the measurement result to the instantaneous heart rate visualization unit 12. The electrocardiogram is a biological signal of the circulatory system, and includes, for example, a periodic signal synchronized with the contraction of the ventricle. The electrocardiogram measurement unit 11 measures the electrocardiogram using at least two electrodes. The measurement result includes data from which an electrocardiogram corresponding to the R wave in the electrocardiogram can be extracted. For example, the measurement results include electrocardiogram data. The electrocardiogram measuring unit 11 only needs to be able to measure an electrocardiographic waveform equivalent to an R wave, and its realization form is not limited. For example, the electrocardiogram measuring unit 11 is formed of a Holter electrocardiograph.

The instantaneous heartbeat visualization unit 12 receives the measurement result from the electrocardiogram measurement unit 11, and visualizes the instantaneous heartbeat of the subject based on the received measurement result. For example, the instantaneous heartbeat visualization unit 12 includes an R-wave extraction unit 121, an R-wave related information recording unit 122, an instantaneous heartbeat calculation unit 123, an instantaneous heartbeat recording unit 124, an instantaneous heartbeat evaluation unit 125, and a color information determination unit 126.
The functions of the R-wave extraction unit 121, the R-wave related information recording unit 122, the instantaneous heartbeat calculation unit 123, the instantaneous heartbeat recording unit 124, the instantaneous heartbeat evaluation unit 125, and the color information determination unit 126 are as follows. It is realized by reading and executing a program that is in use. Some or all of these functions may be realized by a circuit such as an application specific integrated circuit (ASIC).

  The R-wave extraction unit 121 analyzes the electrocardiogram obtained by the electrocardiogram measurement unit 11 and extracts an R-wave. Further, the R-wave extracting unit 121 records the information related to the extracted R-wave in the R-wave related information recording unit 122.

The R-wave related information recording unit 122 includes a storage medium such as a nonvolatile memory, and records the information of the R-wave extracted by the R-wave extraction unit 121 on this storage medium. The process by the R-wave extraction unit 121 is essential when using information on the R-wave that constitutes the instantaneous heartbeat.
In this embodiment, when the information of the R wave constituting the instantaneous heart rate is used, at least two types of measurement states of a normal measurement state and an artifact (abnormal measurement state), which will be described later, can be distinguished because the measurement abnormal R wave is detected. Information is recorded in the R-wave related information recording unit 122, but other information is not specified.

  The instantaneous heartbeat calculating unit 123 calculates an instantaneous heartbeat that is an interval between two adjacent R waves based on the R waves extracted by the R wave extracting unit 121. The instantaneous heartbeat calculation unit 123 can record information indicating the calculated instantaneous heartbeat in the instantaneous heartbeat recording unit 124.

  The instantaneous heartbeat recording unit 124 includes a storage medium such as a nonvolatile memory, and records information indicating the instantaneous heartbeat calculated by the instantaneous heartbeat calculation unit 123 in this storage medium. The processing by the instantaneous heartbeat recording unit 124 is essential when using the time information of the instantaneous heartbeat. Although a specific recording format is not particularly specified, for example, (1) a matrix of instantaneous heartbeats, and (2) data composed of time information of the first R wave and instantaneous heartbeats constituting the instantaneous heartbeat Matrix.

  The instantaneous heartbeat evaluation unit 125 uses one or more types of information recorded in the R-wave related information recording unit 122 or information recorded in the instantaneous heartbeat recording unit 124, based on a value held in each recording unit. Evaluate the instantaneous heart rate. A specific evaluation method will be described in an operation example described later.

  The color information determination unit 126 determines color information (for example, information indicating hue, lightness, and saturation) corresponding to each instantaneous heartbeat calculated by the instantaneous heartbeat calculation unit 123 based on the evaluation result by the instantaneous heartbeat evaluation unit 125. . The processing by the color information determination unit 126 is characterized in that one or more types of information corresponding to hue, lightness, and saturation are determined based on the evaluation result by the instantaneous heart rate evaluation unit 125. Specific processing will be described in the following operation example.

(Operation example)
Next, an operation example of the embodiment will be described. In the present embodiment, “(a) combination information of measurement states of two R waves constituting instantaneous heartbeat”, “(b) order information of measurement states of two R waves constituting instantaneous heartbeat”, “ A description will be given of a case where the color information determination unit 126 determines color information corresponding to each instantaneous heartbeat calculated by the instantaneous heartbeat calculation unit 123 based on three types of information “(c) time information of instantaneous heartbeat”.
In the present embodiment, in order to distinguish the measurement abnormal R wave, three types of measurement states including (1) normal measurement state, (2) noise, and (3) artifact are assumed as the measurement state of the R wave. To make these distinctions, the R-wave extraction unit 121 records the R-wave potential information in the R-wave related information recording unit 122.

The specific processing procedure is shown below. FIG. 2 is a flowchart illustrating an example of a processing procedure by the instantaneous heart rate visualization device according to the embodiment of the present invention.
The electrocardiogram measurement unit 11 measures the electrocardiogram using at least two electrodes (S1).
The R-wave extracting unit 121 extracts an R-wave from the electrocardiogram measured by the electrocardiogram measuring unit 11. The R-wave extracting unit 121 records the extracted potential information of each R-wave in the R-wave related information recording unit 122.

  The instantaneous heartbeat calculation unit 123 calculates an instantaneous heartbeat from two adjacent R waves based on the R wave acquired by the R wave extraction unit 121 (S2). The instantaneous heartbeat calculation unit 123 records information on the calculated instantaneous heartbeat in the instantaneous heartbeat recording unit 124.

  The instantaneous heartbeat evaluating unit 125 evaluates the instantaneous heartbeat based on the R-wave potential information stored in the R-wave related information recording unit 122 and the instantaneous heartbeat time information stored in the instantaneous heartbeat recording unit 124.

  Specifically, first, the instantaneous heart rate evaluation unit 125 first calculates “(a) combination information of the measurement states of the two R waves that constitute the instantaneous heartbeat” based on the potential information of the two R waves that constitute the instantaneous heartbeat. And “(b) Order information of measurement state of two R waves constituting instantaneous heartbeat”. The instantaneous heart rate evaluation unit 125 determines three types of measurement states, ie, a normal measurement state, noise, and artifacts, from the R-wave potential information.

In the present embodiment, the internal memory (not shown) of the instantaneous heart rate evaluation unit 125 stores the evaluation criteria of the measurement state of the R wave described in Table 1 below. When the potential of the R wave indicated by the information stored in the R wave related information recording unit 122 is 3.5 mV or more, it is determined that the measurement state of the R wave is an artifact (S3).
Note that another evaluation criterion may be used as long as the same determination can be made. For example, the instantaneous heart rate evaluation unit 125 may perform abnormality determination based on the statistical information of the electrocardiogram, and evaluate the instantaneous heart rate based on information obtained by combining the result of the abnormality determination and the measured R wave information.

The instantaneous heart rate evaluation unit 125 determines whether or not the R wave determined to be an artifact in S3 is noise (a waveform in which the baseline of the potential fluctuates by a certain amount or more compared to the normal measurement state) ( S4). Regarding this determination, any means can be used as long as the method can detect the baseline fluctuation.
In the present embodiment, the instantaneous heart rate evaluation unit 125 calculates the potential of the R wave to be determined (the tip of the arrow in FIG. 3) and the absolute value of the potential amplitude of the QRS complex (electrocardiogram) including the R wave to be determined. If (see FIG. 3) exceeds the threshold, the R wave is determined to be noise. In the present embodiment, this threshold is assumed to be 0.5 mV. FIG. 3 is a diagram illustrating an example of the relationship between the absolute value of the potential amplitude of the QRS complex and the potential of the R wave.
The instantaneous heart rate evaluation unit 125 determines that the measurement state of the R wave that is not determined to be an artifact or noise in S3 and S4 is a normal measurement state (S5).
Based on the measurement state determined for each R-wave, the instantaneous heart rate evaluation unit 125 calculates the “(a) combination information of the measurement states of the two R waves constituting the instantaneous heartbeat” and “(b) the instantaneous heartbeat”. The order information of the measurement states of the two R waves that constitute it is obtained. When the three types of the normal measurement state, noise, and artifacts are considered, the above-mentioned “(a) combination information of the measurement states of the two R waves constituting the instantaneous heartbeat (sometimes referred to as state details)” and “( b) the sequence information of the measurement states of the two R-waves constituting the instantaneous heartbeat (sometimes simply referred to as the sequence) ”is any of the patterns indicated by the serial numbers # 1 to # 9 shown in Table 2 below. It will be.

“R” of the determination result in Table 2 indicates a normal measurement state, “N” indicates noise, and “A” indicates an artifact. That is, “R, R” of the determination result corresponding to the serial number # 1 in Table 2 indicates that the determination results of the measurement states of the adjacent first and second R waves are both normal measurement states. “R, N” of the determination result corresponding to the serial number # 2 in Table 2 indicates that the determination result of the measurement state of the adjacent first R wave is a normal state and the determination result of the measurement state of the second R wave is Is noise. In the determination result “N, R” corresponding to the serial number # 3 in Table 2, the determination result of the measurement state of the adjacent first R wave is noise, and the determination result of the measurement state of the second R wave is Indicates normal status. “N, N” of the determination result corresponding to the serial number # 4 in Table 2 indicates that the determination results of the measurement states of the first and second adjacent R waves are both noise.
“R, A” of the determination result corresponding to the serial number # 5 in Table 2 indicates that the determination result of the adjacent first R wave measurement state is normal, and the determination result of the second R wave measurement state is normal. Is an artifact. In the determination result “A, R” corresponding to the serial number # 6 in Table 2, the determination result of the measurement state of the adjacent first R wave is an artifact, and the determination result of the measurement state of the second R wave is Indicates normal status. “N, A” of the determination result corresponding to the serial number # 7 in Table 2 indicates that the determination result of the measurement state of the adjacent first R wave is noise and the determination result of the measurement state of the second R wave is Indicates an artifact. In the determination result “A, N” corresponding to the serial number # 8 in Table 2, the determination result of the measurement state of the adjacent first R wave is an artifact, and the determination result of the measurement state of the second R wave is Indicates noise. “A, A” of the determination result corresponding to the serial number # 9 in Table 2 indicates that both the determination results of the measurement states of the adjacent first and second R waves are artifacts.

“(A) Details of state” in Table 2 means “(a) combination information of the measurement states of the two R waves constituting the instantaneous heartbeat” and is based on the determination result of the same row in Table 2. The details of the measurement state of two adjacent R waves are shown.
In the example shown in Table 2, there are nine combinations of the determination results of the measurement states corresponding to the serial numbers # 1 to # 9, but the “(a) state details” corresponding to # 2 and # 3 are the same “ "One is a normal measurement state, the other is noise", and "(a) State details" corresponding to # 5 and # 6 are the same "One is a normal measurement state, the other is artifact" and correspond to # 7 and # 8 The “details of the (a) state” are the same “one is a noise and the other is an artifact”, and thus “details of the (a) state” in Table 2 are six types.

The “(b) order” in Table 2 is “(b) the order information of the measurement states of the two R waves constituting the instantaneous heartbeat”, and two (2) indicated by the determination result of the same row in Table 2. If the measurement state of the R wave is the same, the value of “(b) order” in Table 2 is expressed as “0”.
Further, when the measurement states of the two R-waves, which are indicated by the determination result of the same row in Table 2, are different, it is defined that the noise is a measurement state better than the artifact and the normal measurement state is a measurement state better than the noise. Will be explained. For example, if the measurement state of the first R wave measured first, that is, the measurement state of the second R wave is better than the measurement state of the second R wave measured later (for example, as in the row of the serial number # 2 in Table 2, When the measurement state of the first R wave is “R” and the measurement state of the second R wave is “N”, the value of “(b) order” in Table 2 is set to “1”. Express, if the measurement state of the second R wave is better than the measurement state of the first R wave (for example, the measurement state of the first R wave is When “N” and the measurement state of the second R wave is “R”), the value of “(b) order” in Table 2 is expressed as “−1”. Here, the value of “(b) order” is represented as “0”, “1”, or “−1” according to the measurement state of each R wave, but is not limited thereto, and for example, “0”, “ 5 "," -5 "," 0 "," 100 "," -100 "," 0 "," 1 "," 4 ", and the like. That is, as long as the order of the measurement states of the two R-waves constituting the instantaneous heartbeat and the values are in correspondence, the sign of each value does not matter. Further, each value may not be a continuous value.

As shown in Table 2, the instantaneous heart rate evaluation unit 125 generates information that can distinguish details of the measurement state of the R wave. In the present embodiment, “(a) the details of the measurement state of the two R-waves constituting the instantaneous heartbeat” and “(b) the order information of the measurement state of the two R-waves constituting the instantaneous heartbeat” are collectively referred to as serial numbers. Using (# 1, # 2,...), Associated information is generated as shown in Table 2 and stored in the internal memory.
Then, the instantaneous heart rate evaluating unit 125 compares the information shown in Table 2 with the determination result of the measurement state of the two R waves constituting the instantaneous heart rate recorded in the instantaneous heart rate recording unit 124, and finds the corresponding “(a ) State Details ”and“ (b) Order ”values are specified from the information shown in Table 2, and the specified result is calculated based on the instantaneous heartbeat calculated by the instantaneous heartbeat calculation unit 123. Of the measurement states of the two R waves to be performed "and" (b) Order information of the measurement states of the two R waves forming the instantaneous heartbeat "(S6). Note that the format of the serial number is not limited to the above.

The instantaneous heartbeat evaluation unit 125 evaluates the time information of the instantaneous heartbeat based on the information recorded in the instantaneous heartbeat recording unit 124 (S7). The evaluation of the time information only needs to be able to evaluate the length of the instantaneous heartbeat, and a specific evaluation method is not specified in this embodiment. In the present embodiment, three types of time information of extended, normal, and shortened are assumed based on the time information of a normal instantaneous heartbeat. It is stored in the internal memory of the unit 125.
Then, the instantaneous heart rate evaluation unit 125 collates the evaluation criterion of each row indicated by the column of the evaluation criterion in Table 3 with the instantaneous heartbeat recorded in the instantaneous heart rate recording unit 124, and among the evaluation criteria of each row in Table 3, The relationship between one instantaneous heartbeat (RRI) to be evaluated, the average μ of all the instantaneous heartbeats to be evaluated, and the standard deviation σ satisfies the condition. Then, the instantaneous heart rate evaluating unit 125 specifies any one of “extended”, “normal”, and “shortened” in the column of “(c) time information” associated with the column of the evaluation criterion, and the specified result Is evaluated as “(c) instantaneous heartbeat time information” for the instantaneous heartbeat calculated by the instantaneous heartbeat calculation unit 123.

  Next, the color information determination unit 126 calculates “(a)” of the two R waves constituting the instantaneous heartbeat regarding the instantaneous heartbeat calculated by the instantaneous heartbeat calculation unit 123, which is obtained by the instantaneous heartbeat evaluation unit 125 in S6 and S7. Colors for visualizing these information based on "combination information of state", "(b) Order information of measurement state of two R waves constituting instantaneous heartbeat", and "(c) Time information of instantaneous heartbeat" Determine information. In the present embodiment, a case will be described in which the hue, lightness, and saturation, which are color element information, and various information (a), (b), and (c) of the instantaneous heartbeat are associated as follows.

Color information corresponding to "(a) combination information of measurement states of two R waves constituting instantaneous heartbeat": hue Corresponding to "(b) Order information of measurement states of two R waves constituting instantaneous heartbeat" Color information: Lightness Color information corresponding to “(c) Instantaneous heartbeat time information”: Saturation Note that the type (hue, lightness, saturation) of color element information and various information (a), ( The correspondence between b) and (c) is not limited to the above. For example, the element information corresponding to “(a) combination information of measurement states of two R waves constituting instantaneous heartbeat” is kept as described above, and “(b) two R waves constituting instantaneous heartbeat are maintained. May be changed to saturation, and the element information corresponding to "(c) instantaneous heartbeat time information" may be changed to lightness. An example of setting the types of hue, lightness, and saturation will be described below. However, if the colors according to the above (a), (b), and (c) can be distinguished, the setting contents are particularly limited. Absent.
Further, in the present embodiment, the instantaneous heart rate evaluation unit 125 generates the color information corresponding to the “(a) combination information of the measurement states of the two R waves constituting the instantaneous heart rate” and “(b) configures the instant heart rate. In the form of not evaluating all of the order information of the measurement states of the two R waves to be performed "and" (c) the time information of the instantaneous heartbeat ", for example, in the form of evaluating only one of the above or in the form of evaluating only two of the above. There may be. For example, the instantaneous heartbeat evaluation unit 125 does not evaluate “(c) instantaneous heartbeat time information”, but “(a) combination information of measurement states of two R waves constituting the instantaneous heartbeat” and “(b) instantaneous heartbeat”. , The order information of the measurement states of the two R-waves that constitutes the two types of information ”, the element information of the colors respectively corresponding to the remaining information to be evaluated is calculated from the above hue, lightness, and saturation. There may be two types.

  Hereinafter, details of the setting of the hue, lightness, and saturation will be described. The color information determination unit 126 sets a hue corresponding to each of “(a) combination information of measurement states of two R waves constituting an instantaneous heartbeat” in each row shown in Table 2, and stores this information in an internal memory. It is stored (S8). In the present embodiment, as shown in Table 4 below, the hue is set in each row of # 1 to # 9 in the column of “corresponding hue of (a)” in Table 4 so that the color changes from blue to red as the serial number increases. Is set, and this information is stored in an internal memory (not shown).

  In Table 4, the hue corresponding to "(a) information details" is indicated as "(a) corresponding hue", and the lightness corresponding to "(b) order" is indicated as "(b) corresponding lightness". An example is shown in which color information determined by the hue determined by “(a) information details” and the brightness determined by “(b) order” is represented by “color determined by (a) and (b)”.

Further, the color information determination unit 126 sets the brightness corresponding to the value of “(b) order” shown in Table 2 in each row of # 1 to # 9 in the column of “(b) order” in Table 4. This information is stored in the internal memory (S9). In the present embodiment, the color information determination unit 126 displays the brightness using the pure color as it is when both the determination results of the measurement states of the two R waves are normal (“(b) order” value = 0). 4 is set in the corresponding row in the column of “(b) order”.
Further, the color information determination unit 126 sets the pure color when the determination result of one of the measurement states is the abnormal measurement R wave and the state of the previously measured R wave is good (“(b) order” value = 1). Brightness is set in a corresponding row in the column of “(b) order” in Table 4 and when the state of the R wave measured later is good (the value of “(b) order” = −). 1) sets a lightness that is darker than a pure color in a corresponding row in the column of “(b) order” in Table 4.

  In the example shown in Table 4, the color information determination unit 126 uses the gray scale, and when the value of the “(b) order” of a certain row = 0, the brightness remains pure (expressed in gray in Table 4). Is set in the column of “corresponding brightness of (b)” in the same row, and when the value of “order of (b)” in a row = 1, the brightness is 1.2 times the brightness of the pure color (in Table 4, Is expressed in light gray, which is lighter than gray) in the column of “corresponding lightness of (b)” in the same row, and when the value of “(b) order” in a row is −1, The lightness of 0.8 times (in Table 4, expressed in black, which is a color darker than the above gray) is set in the column of “corresponding lightness of (b)” in the same row.

Further, the color information determination unit 126 converts color information determined by the hue set in S8 and the brightness set in S9 into # 1 to # 1 in the column of "color determined by (a) and (b)" in Table 4. 9, and this information is stored in the internal memory.
The color information determination unit 126 calculates the saturation defined to correspond to each of “extended”, “normal”, and “shortened” of “(c) instantaneous heartbeat time information” shown in Table 3, and The color information determined by the color indicated by “a color determined by (a) and (b)”, that is, the color information reflecting the hue, lightness, and saturation is described in “(a), (b), (c) in Table 5 below. ) Is set in each row of # 1 to # 9 corresponding to each column of “(c) extended”, “(c) normal”, and “(c) shortened” of the color determined by the color, and this information is stored in the internal memory. (S10).

  In the present embodiment, when the “(c) instantaneous heartbeat time information” obtained according to Table 3 is “extended”, the color information determination unit 126 uses the same saturation as the pure color. Based on this, the color information determination unit 126 sets the lower chroma in the order of “(c) instantaneous heartbeat time information” obtained according to Table 3 when “normal” and “shortened”. I do.

  In the example shown in Table 5, the color information determination unit 126 determines that the saturation decreases in the order of “extended”, “normal”, and “shortened” which are “(c) instantaneous heartbeat time information”. In Table 5, the color codes of “colors determined by (a), (b), (c)” are replaced by “(c) extension”, “colors determined by (a), (b), (c)” in Table 5. This is set for each row of # 1 to # 9 corresponding to each column of "(c) normal" and "(c) shortened".

  In the example shown in Table 5, the color information determination unit 126 sets the saturation when “(c) instantaneous heartbeat time information” is “extended” to “255 (equivalent to pure color)” in the HSL system (table 5, the saturation when “(c) instantaneous heartbeat time information” is “normal” is set to “200” of the HSL system (for example, in Table 5, for example, “blue (high saturation)”). In the case of “blue (medium saturation)”, the saturation when “(c) instantaneous heartbeat time information” is “shortened” is HSL system “150” (in Table 5, for example, “blue (saturation)”). This is an example in which the expression is set as “low”).

  Next, the color information determination unit 126 calculates “(a)” of the two R waves constituting the instantaneous heartbeat regarding the instantaneous heartbeat calculated by the instantaneous heartbeat calculation unit 123, which is obtained by the instantaneous heartbeat evaluation unit 125 in S6 and S7. State combination information "," (b) the order information of the measurement states of the two R waves constituting the instantaneous heartbeat ", and" (c) the time information of the instantaneous heartbeat "and the information shown in Tables 2 and 3. By collation, “(a)“ detailed state ”,“ (b) order ”, and“ (c) time information ”regarding the instantaneous heartbeat evaluated by the instantaneous heartbeat evaluation unit 125 are obtained.

  Then, the color information determination unit 126 collates the obtained information with the information shown in Table 5 to obtain the instantaneous heartbeat evaluated by the instantaneous heartbeat evaluation unit 125 as “(a)“ 2 constituting the instantaneous heartbeat ”. Color information for visualizing "combination information of measurement states of two R waves", "(b) order information of measurement states of two R waves constituting instantaneous heartbeat", and "(c) time information of instantaneous heartbeat". The specified color information is specified from Table 5, and is displayed on a monitor (not shown) or the like (S11). Thereby, the characteristics of the instantaneous heartbeat can be visualized.

In the present embodiment, in order to determine the color code of the saturation, the condition is that the information on the instantaneous heartbeat to be calculated includes one or more, but other information may not be included.
For example, when each of the instantaneous heartbeats is represented by a circle, the color information determination unit 126 determines the information of “(a) the combination of the measurement states of the two R waves constituting the instantaneous heartbeat” and “(b) The color code is determined based on the information of "the order of the measurement states of the two R waves constituting the instantaneous heartbeat", and the size of the circle drawn for the instantaneous heartbeat is determined based on "(c) time information of the instantaneous heartbeat". Alternatively, a visualization method such as determining may be performed. In the present embodiment, the style of the graphic for drawing the instantaneous heartbeat using the color code is not particularly defined.

The effect produced by the present invention will be described.
According to the present invention, the instantaneous heartbeat is divided into patterns based on at least one type of information of the R wave or the instantaneous heartbeat time information that constitutes the instantaneous heartbeat, and the corresponding color code is determined according to the pattern. Intuitive visualization of measurement status and temporal characteristics of

  In the present invention, the color code used to visualize the instantaneous heartbeat is determined based on the information on the instantaneous heartbeat, so that it can be combined with a conventional visualization method such as a graph or Lorentz plot. That is, in the conventional visualization method, it becomes possible to provide a visualization method of the measurement state of the instantaneous heartbeat and the temporal characteristic.

  It should be noted that the present invention is not limited to the above-described embodiment, and can be variously modified in an implementation stage without departing from the scope of the invention. In addition, the embodiments may be implemented in appropriate combinations as much as possible, in which case the combined effects can be obtained. Furthermore, the above embodiments include inventions at various stages, and various inventions can be extracted by appropriate combinations of a plurality of disclosed constituent elements. For example, even if some components are deleted from all the components shown in the embodiment, the problem described in the column of the problem to be solved by the invention can be solved and the effects described in the column of the effect of the invention can be solved. Is obtained, a configuration from which this configuration requirement is deleted can be extracted as an invention.

  In addition, the method described in each embodiment can be executed by a computer (computer) as a program (software means) such as a magnetic disk (floppy (registered trademark) disk, hard disk, or the like), an optical disk (CD-ROM, It can be stored in a recording medium such as a DVD, MO, or a semiconductor memory (ROM, RAM, flash memory, etc.), and can also be transmitted and distributed via a communication medium. The program stored on the medium side includes a setting program for causing the computer to execute software means (including not only the execution program but also tables and data structures) to be executed in the computer. A computer that implements the present apparatus reads a program recorded on a recording medium, and in some cases, constructs software means using a setting program, and executes the above-described processing by controlling the operation of the software means. The recording medium referred to in the present specification is not limited to a medium for distribution, but includes a storage medium such as a magnetic disk or a semiconductor memory provided in a computer or a device connected via a network.

  Reference Signs List 10: instantaneous heartbeat visualization device, 11: electrocardiogram measurement unit, 12: instantaneous heartbeat visualization unit, 121: R-wave extraction unit, 122: R-wave related information recording unit, 123: instantaneous heartbeat calculation unit, 124: instantaneous heartbeat recording unit, 125: Instantaneous heart rate evaluation unit; 126: Color information determination unit.

Claims (6)

Extracting means for extracting an R wave of the electrocardiogram based on a signal output from the electrocardiographic measuring means for measuring the electrocardiogram of the subject;
Calculating means for calculating at least two instantaneous heartbeats which are intervals between two time-series adjacent R waves extracted by the extracting means;
Evaluation means for evaluating the measurement state of the instantaneous heartbeat calculated by the calculation means, which is the interval between the R waves, according to the type of each measurement state of the two adjacent R waves extracted by the extraction means; ,
For the instantaneous heart rate evaluated by the evaluation means, color information determination means for determining color information according to the type of the evaluation,
The measurement state of the R wave includes a first measurement state of the R wave, a second measurement state of the R wave, and a third measurement state of the R wave,
The first measurement state of the R wave is an abnormal measurement state in which the potential of the R wave has a magnitude satisfying a condition,
The second measurement state of the R-wave is noise in which the potential of the R-wave does not have the magnitude satisfying the condition, while the fluctuation of the baseline of the R-wave potential satisfies the condition,
The third measurement state of the R-wave, the abnormal measurement state and instantaneous heartbeat evaluation device Ru normal measurement state der does not correspond to the noise. The instantaneous heartbeat measurement state includes the instantaneous heartbeat first measurement state, the instantaneous heartbeat second measurement state, the instantaneous heartbeat third measurement state, the instantaneous heartbeat fourth measurement state, and the instantaneous heartbeat measurement state. A fifth measurement state of the heartbeat, and a sixth measurement state of the instantaneous heartbeat,
The first measurement state of the instantaneous heartbeat indicates that the measurement state of one and the other R waves constituting the instantaneous heartbeat is both the normal measurement state,
The second measurement state of the instantaneous heartbeat indicates that the measurement state of one R wave constituting the instantaneous heartbeat is the normal measurement state, and the other measurement state is the noise,
The third measurement state of the instantaneous heartbeat indicates that the measurement state of one and the other R-waves constituting the instantaneous heartbeat is both the noise,
The fourth measurement state of the instantaneous heartbeat indicates that the measurement state of one R wave constituting the instantaneous heartbeat is the normal measurement state, and the other measurement state is the abnormal measurement state,
The fifth measurement state of the instantaneous heartbeat indicates that the measurement state of one R wave constituting the instantaneous heartbeat is the noise, and the other measurement state is the abnormal measurement state,
2. The instantaneous heart rate evaluation device according to claim 1 , wherein the sixth measurement state of the instantaneous heart beat indicates that both the measurement states of one and the other R waves constituting the instantaneous heartbeat are the abnormal measurement states. The evaluation means,
In the measurement state of the instantaneous heartbeat, the order of the measurement state of the subsequent R wave with respect to the measurement state of the previous R wave in the time series configuring the instantaneous heartbeat is evaluated,
The color information determining means,
The instantaneous heart rate evaluation device according to claim 2 , wherein the color information is determined based on a type of the evaluation of the instantaneous heart rate by the evaluation unit and the order evaluated by the evaluation unit. The evaluation means,
Assessing the length of the instantaneous heartbeat,
The color information determining means,
4. The color information according to claim 3 , wherein the color information is determined based on a type of the evaluation of the instantaneous heartbeat by the evaluation unit, the order evaluated by the evaluation unit, and a length of time of the instantaneous heartbeat evaluated by the evaluation unit. Instantaneous heart rate evaluation device. A method applied to the device,
Extracting the R wave of the electrocardiogram based on the signal output from the electrocardiogram measuring means for measuring the electrocardiogram of the subject,
Calculating at least two instantaneous heartbeats, which are intervals between two extracted R-waves adjacent in time series,
According to the type of the measurement state of each of the extracted two adjacent R waves, the measurement state of the calculated instantaneous heartbeat, which is the interval between the R waves, is evaluated,
For the evaluated instantaneous heartbeat, determine color information according to the type of the evaluation ,
The measurement state of the R wave includes a first measurement state of the R wave, a second measurement state of the R wave, and a third measurement state of the R wave,
The first measurement state of the R wave is an abnormal measurement state in which the potential of the R wave has a magnitude satisfying a condition,
The second measurement state of the R-wave is noise in which the potential of the R-wave does not have the magnitude satisfying the condition, while the fluctuation of the baseline of the R-wave potential satisfies the condition,
The instantaneous heart rate evaluation method , wherein the third measurement state of the R wave is the abnormal measurement state and the normal measurement state that does not correspond to the noise . A program used in a computer that operates as a part of the instantaneous heart rate evaluation device according to claim 1,
Said computer,
An instantaneous heart rate evaluation processing program for functioning as the extraction unit, the calculation unit, the evaluation unit, and the color information determination unit.