JP6656822B2 - Effervescent tablet and method for producing the same - Google Patents
Effervescent tablet and method for producing the same Download PDFInfo
- Publication number
- JP6656822B2 JP6656822B2 JP2015104872A JP2015104872A JP6656822B2 JP 6656822 B2 JP6656822 B2 JP 6656822B2 JP 2015104872 A JP2015104872 A JP 2015104872A JP 2015104872 A JP2015104872 A JP 2015104872A JP 6656822 B2 JP6656822 B2 JP 6656822B2
- Authority
- JP
- Japan
- Prior art keywords
- tablet
- effervescent
- effervescent tablet
- component
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000007938 effervescent tablet Substances 0.000 title claims description 120
- 238000004519 manufacturing process Methods 0.000 title claims description 34
- 239000003826 tablet Substances 0.000 claims description 96
- 239000003205 fragrance Substances 0.000 claims description 27
- 239000000203 mixture Substances 0.000 claims description 25
- JRKICGRDRMAZLK-UHFFFAOYSA-L peroxydisulfate Chemical compound [O-]S(=O)(=O)OOS([O-])(=O)=O JRKICGRDRMAZLK-UHFFFAOYSA-L 0.000 claims description 13
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims description 11
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 10
- 150000007522 mineralic acids Chemical class 0.000 claims description 9
- 150000007524 organic acids Chemical class 0.000 claims description 9
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 8
- 239000001257 hydrogen Substances 0.000 claims description 8
- 229910052739 hydrogen Inorganic materials 0.000 claims description 8
- 239000000796 flavoring agent Substances 0.000 description 56
- 235000019634 flavors Nutrition 0.000 description 56
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 26
- 230000000052 comparative effect Effects 0.000 description 19
- -1 alkali metal salts Chemical class 0.000 description 17
- 230000000694 effects Effects 0.000 description 16
- 239000000546 pharmaceutical excipient Substances 0.000 description 15
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 14
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 14
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 12
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 12
- 239000002304 perfume Substances 0.000 description 11
- 238000004061 bleaching Methods 0.000 description 10
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 8
- 229910052783 alkali metal Inorganic materials 0.000 description 8
- 238000005406 washing Methods 0.000 description 8
- 235000006679 Mentha X verticillata Nutrition 0.000 description 7
- 235000002899 Mentha suaveolens Nutrition 0.000 description 7
- 235000001636 Mentha x rotundifolia Nutrition 0.000 description 7
- 239000001569 carbon dioxide Substances 0.000 description 7
- 229910002092 carbon dioxide Inorganic materials 0.000 description 7
- 150000003839 salts Chemical class 0.000 description 7
- 229910000029 sodium carbonate Inorganic materials 0.000 description 7
- XSVSPKKXQGNHMD-UHFFFAOYSA-N 5-bromo-3-methyl-1,2-thiazole Chemical compound CC=1C=C(Br)SN=1 XSVSPKKXQGNHMD-UHFFFAOYSA-N 0.000 description 6
- 235000019359 magnesium stearate Nutrition 0.000 description 6
- 239000004094 surface-active agent Substances 0.000 description 6
- 238000005187 foaming Methods 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- LNOPIUAQISRISI-UHFFFAOYSA-N n'-hydroxy-2-propan-2-ylsulfonylethanimidamide Chemical compound CC(C)S(=O)(=O)CC(N)=NO LNOPIUAQISRISI-UHFFFAOYSA-N 0.000 description 5
- 229920001223 polyethylene glycol Polymers 0.000 description 5
- 239000011734 sodium Substances 0.000 description 5
- 229910052708 sodium Inorganic materials 0.000 description 5
- FRPJTGXMTIIFIT-UHFFFAOYSA-N tetraacetylethylenediamine Chemical compound CC(=O)C(N)(C(C)=O)C(N)(C(C)=O)C(C)=O FRPJTGXMTIIFIT-UHFFFAOYSA-N 0.000 description 5
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 4
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 4
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 4
- GLZPCOQZEFWAFX-UHFFFAOYSA-N Geraniol Chemical compound CC(C)=CCCC(C)=CCO GLZPCOQZEFWAFX-UHFFFAOYSA-N 0.000 description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 4
- 239000002202 Polyethylene glycol Substances 0.000 description 4
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 4
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 4
- 239000002738 chelating agent Substances 0.000 description 4
- 235000015165 citric acid Nutrition 0.000 description 4
- 239000012141 concentrate Substances 0.000 description 4
- 238000011156 evaluation Methods 0.000 description 4
- 230000001771 impaired effect Effects 0.000 description 4
- 239000003921 oil Substances 0.000 description 4
- 235000019198 oils Nutrition 0.000 description 4
- 238000007789 sealing Methods 0.000 description 4
- 239000000377 silicon dioxide Substances 0.000 description 4
- 235000012239 silicon dioxide Nutrition 0.000 description 4
- 229910052938 sodium sulfate Inorganic materials 0.000 description 4
- 235000011152 sodium sulphate Nutrition 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 229960002920 sorbitol Drugs 0.000 description 4
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 3
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 239000007844 bleaching agent Substances 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 238000007796 conventional method Methods 0.000 description 3
- 239000004088 foaming agent Substances 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- NUJGJRNETVAIRJ-UHFFFAOYSA-N octanal Chemical compound CCCCCCCC=O NUJGJRNETVAIRJ-UHFFFAOYSA-N 0.000 description 3
- 235000005985 organic acids Nutrition 0.000 description 3
- 229940075560 sodium lauryl sulfoacetate Drugs 0.000 description 3
- UAJTZZNRJCKXJN-UHFFFAOYSA-M sodium;2-dodecoxy-2-oxoethanesulfonate Chemical compound [Na+].CCCCCCCCCCCCOC(=O)CS([O-])(=O)=O UAJTZZNRJCKXJN-UHFFFAOYSA-M 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 3
- GRWFGVWFFZKLTI-IUCAKERBSA-N (-)-α-pinene Chemical compound CC1=CC[C@@H]2C(C)(C)[C@H]1C2 GRWFGVWFFZKLTI-IUCAKERBSA-N 0.000 description 2
- ZCHHRLHTBGRGOT-SNAWJCMRSA-N (E)-hex-2-en-1-ol Chemical compound CCC\C=C\CO ZCHHRLHTBGRGOT-SNAWJCMRSA-N 0.000 description 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 2
- ZPVFWPFBNIEHGJ-UHFFFAOYSA-N 2-octanone Chemical compound CCCCCCC(C)=O ZPVFWPFBNIEHGJ-UHFFFAOYSA-N 0.000 description 2
- XPCTZQVDEJYUGT-UHFFFAOYSA-N 3-hydroxy-2-methyl-4-pyrone Chemical compound CC=1OC=CC(=O)C=1O XPCTZQVDEJYUGT-UHFFFAOYSA-N 0.000 description 2
- GNKZMNRKLCTJAY-UHFFFAOYSA-N 4'-Methylacetophenone Chemical compound CC(=O)C1=CC=C(C)C=C1 GNKZMNRKLCTJAY-UHFFFAOYSA-N 0.000 description 2
- ROWKJAVDOGWPAT-UHFFFAOYSA-N Acetoin Chemical compound CC(O)C(C)=O ROWKJAVDOGWPAT-UHFFFAOYSA-N 0.000 description 2
- KWOLFJPFCHCOCG-UHFFFAOYSA-N Acetophenone Chemical compound CC(=O)C1=CC=CC=C1 KWOLFJPFCHCOCG-UHFFFAOYSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
- WEEGYLXZBRQIMU-UHFFFAOYSA-N Eucalyptol Chemical compound C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 description 2
- LHXDLQBQYFFVNW-UHFFFAOYSA-N Fenchone Chemical compound C1CC2(C)C(=O)C(C)(C)C1C2 LHXDLQBQYFFVNW-UHFFFAOYSA-N 0.000 description 2
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
- KFSLWBXXFJQRDL-UHFFFAOYSA-N Peracetic acid Chemical compound CC(=O)OO KFSLWBXXFJQRDL-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 2
- 150000001299 aldehydes Chemical class 0.000 description 2
- 150000001340 alkali metals Chemical class 0.000 description 2
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 2
- ROOXNKNUYICQNP-UHFFFAOYSA-N ammonium persulfate Chemical compound [NH4+].[NH4+].[O-]S(=O)(=O)OOS([O-])(=O)=O ROOXNKNUYICQNP-UHFFFAOYSA-N 0.000 description 2
- 150000008064 anhydrides Chemical class 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- HUMNYLRZRPPJDN-UHFFFAOYSA-N benzaldehyde Chemical compound O=CC1=CC=CC=C1 HUMNYLRZRPPJDN-UHFFFAOYSA-N 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- AKGGYBADQZYZPD-UHFFFAOYSA-N benzylacetone Chemical compound CC(=O)CCC1=CC=CC=C1 AKGGYBADQZYZPD-UHFFFAOYSA-N 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 2
- CRPUJAZIXJMDBK-UHFFFAOYSA-N camphene Chemical compound C1CC2C(=C)C(C)(C)C1C2 CRPUJAZIXJMDBK-UHFFFAOYSA-N 0.000 description 2
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 2
- ULDHMXUKGWMISQ-UHFFFAOYSA-N carvone Chemical compound CC(=C)C1CC=C(C)C(=O)C1 ULDHMXUKGWMISQ-UHFFFAOYSA-N 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 235000010980 cellulose Nutrition 0.000 description 2
- NEHNMFOYXAPHSD-UHFFFAOYSA-N citronellal Chemical compound O=CCC(C)CCC=C(C)C NEHNMFOYXAPHSD-UHFFFAOYSA-N 0.000 description 2
- QMVPMAAFGQKVCJ-UHFFFAOYSA-N citronellol Chemical compound OCCC(C)CCC=C(C)C QMVPMAAFGQKVCJ-UHFFFAOYSA-N 0.000 description 2
- JOZKFWLRHCDGJA-UHFFFAOYSA-N citronellol acetate Chemical compound CC(=O)OCCC(C)CCC=C(C)C JOZKFWLRHCDGJA-UHFFFAOYSA-N 0.000 description 2
- 235000019820 disodium diphosphate Nutrition 0.000 description 2
- GYQBBRRVRKFJRG-UHFFFAOYSA-L disodium pyrophosphate Chemical compound [Na+].[Na+].OP([O-])(=O)OP(O)([O-])=O GYQBBRRVRKFJRG-UHFFFAOYSA-L 0.000 description 2
- HCRBXQFHJMCTLF-ZCFIWIBFSA-N ethyl (2r)-2-methylbutanoate Chemical compound CCOC(=O)[C@H](C)CC HCRBXQFHJMCTLF-ZCFIWIBFSA-N 0.000 description 2
- WDAXFOBOLVPGLV-UHFFFAOYSA-N ethyl isobutyrate Chemical compound CCOC(=O)C(C)C WDAXFOBOLVPGLV-UHFFFAOYSA-N 0.000 description 2
- FKRCODPIKNYEAC-UHFFFAOYSA-N ethyl propionate Chemical compound CCOC(=O)CC FKRCODPIKNYEAC-UHFFFAOYSA-N 0.000 description 2
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 description 2
- 239000001530 fumaric acid Substances 0.000 description 2
- 235000011087 fumaric acid Nutrition 0.000 description 2
- AOGQPLXWSUTHQB-UHFFFAOYSA-N hexyl acetate Chemical compound CCCCCCOC(C)=O AOGQPLXWSUTHQB-UHFFFAOYSA-N 0.000 description 2
- 150000004677 hydrates Chemical class 0.000 description 2
- PEYVWSJAZONVQK-UHFFFAOYSA-N hydroperoxy(oxo)borane Chemical compound OOB=O PEYVWSJAZONVQK-UHFFFAOYSA-N 0.000 description 2
- MLFHJEHSLIIPHL-UHFFFAOYSA-N isoamyl acetate Chemical compound CC(C)CCOC(C)=O MLFHJEHSLIIPHL-UHFFFAOYSA-N 0.000 description 2
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 2
- UWKAYLJWKGQEPM-LBPRGKRZSA-N linalyl acetate Chemical compound CC(C)=CCC[C@](C)(C=C)OC(C)=O UWKAYLJWKGQEPM-LBPRGKRZSA-N 0.000 description 2
- 229910052744 lithium Inorganic materials 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 2
- 235000019341 magnesium sulphate Nutrition 0.000 description 2
- 239000001630 malic acid Substances 0.000 description 2
- 235000011090 malic acid Nutrition 0.000 description 2
- NMRPBPVERJPACX-UHFFFAOYSA-N octan-3-ol Chemical compound CCCCCC(O)CC NMRPBPVERJPACX-UHFFFAOYSA-N 0.000 description 2
- HFPZCAJZSCWRBC-UHFFFAOYSA-N p-cymene Chemical compound CC(C)C1=CC=C(C)C=C1 HFPZCAJZSCWRBC-UHFFFAOYSA-N 0.000 description 2
- 239000012466 permeate Substances 0.000 description 2
- 150000004968 peroxymonosulfuric acids Chemical class 0.000 description 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
- USHAGKDGDHPEEY-UHFFFAOYSA-L potassium persulfate Chemical compound [K+].[K+].[O-]S(=O)(=O)OOS([O-])(=O)=O USHAGKDGDHPEEY-UHFFFAOYSA-L 0.000 description 2
- HDMGAZBPFLDBCX-UHFFFAOYSA-M potassium;sulfooxy sulfate Chemical compound [K+].OS(=O)(=O)OOS([O-])(=O)=O HDMGAZBPFLDBCX-UHFFFAOYSA-M 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 230000001007 puffing effect Effects 0.000 description 2
- 235000019719 rose oil Nutrition 0.000 description 2
- 239000010666 rose oil Substances 0.000 description 2
- CZCBTSFUTPZVKJ-UHFFFAOYSA-N rose oxide Chemical compound CC1CCOC(C=C(C)C)C1 CZCBTSFUTPZVKJ-UHFFFAOYSA-N 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 2
- 235000017557 sodium bicarbonate Nutrition 0.000 description 2
- 229960001922 sodium perborate Drugs 0.000 description 2
- YKLJGMBLPUQQOI-UHFFFAOYSA-M sodium;oxidooxy(oxo)borane Chemical compound [Na+].[O-]OB=O YKLJGMBLPUQQOI-UHFFFAOYSA-M 0.000 description 2
- 239000000600 sorbitol Substances 0.000 description 2
- 235000010356 sorbitol Nutrition 0.000 description 2
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 2
- 239000000454 talc Substances 0.000 description 2
- 229910052623 talc Inorganic materials 0.000 description 2
- RUVINXPYWBROJD-ONEGZZNKSA-N trans-anethole Chemical compound COC1=CC=C(\C=C\C)C=C1 RUVINXPYWBROJD-ONEGZZNKSA-N 0.000 description 2
- KMPQYAYAQWNLME-UHFFFAOYSA-N undecanal Chemical compound CCCCCCCCCCC=O KMPQYAYAQWNLME-UHFFFAOYSA-N 0.000 description 2
- 239000004711 α-olefin Substances 0.000 description 2
- FQTLCLSUCSAZDY-UHFFFAOYSA-N (+) E(S) nerolidol Natural products CC(C)=CCCC(C)=CCCC(C)(O)C=C FQTLCLSUCSAZDY-UHFFFAOYSA-N 0.000 description 1
- LHXDLQBQYFFVNW-XCBNKYQSSA-N (+)-Fenchone Natural products C1C[C@]2(C)C(=O)C(C)(C)[C@H]1C2 LHXDLQBQYFFVNW-XCBNKYQSSA-N 0.000 description 1
- NFLGAXVYCFJBMK-RKDXNWHRSA-N (+)-isomenthone Natural products CC(C)[C@H]1CC[C@@H](C)CC1=O NFLGAXVYCFJBMK-RKDXNWHRSA-N 0.000 description 1
- NZGWDASTMWDZIW-MRVPVSSYSA-N (+)-pulegone Chemical compound C[C@@H]1CCC(=C(C)C)C(=O)C1 NZGWDASTMWDZIW-MRVPVSSYSA-N 0.000 description 1
- FINOAUDUYKVGDS-UHFFFAOYSA-N (2-tert-butylcyclohexyl) acetate Chemical compound CC(=O)OC1CCCCC1C(C)(C)C FINOAUDUYKVGDS-UHFFFAOYSA-N 0.000 description 1
- QMVPMAAFGQKVCJ-SNVBAGLBSA-N (R)-(+)-citronellol Natural products OCC[C@H](C)CCC=C(C)C QMVPMAAFGQKVCJ-SNVBAGLBSA-N 0.000 description 1
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 1
- UFLHIIWVXFIJGU-ARJAWSKDSA-N (Z)-hex-3-en-1-ol Chemical compound CC\C=C/CCO UFLHIIWVXFIJGU-ARJAWSKDSA-N 0.000 description 1
- YFKBXYGUSOXJGS-UHFFFAOYSA-N 1,3-Diphenyl-2-propanone Chemical compound C=1C=CC=CC=1CC(=O)CC1=CC=CC=C1 YFKBXYGUSOXJGS-UHFFFAOYSA-N 0.000 description 1
- OEVIJAZJVZDBQL-UHFFFAOYSA-N 1-(5,5-dimethylcyclohexen-1-yl)pent-4-en-1-one Chemical compound CC1(C)CCC=C(C(=O)CCC=C)C1 OEVIJAZJVZDBQL-UHFFFAOYSA-N 0.000 description 1
- CHLICZRVGGXEOD-UHFFFAOYSA-N 1-Methoxy-4-methylbenzene Chemical compound COC1=CC=C(C)C=C1 CHLICZRVGGXEOD-UHFFFAOYSA-N 0.000 description 1
- HNAGHMKIPMKKBB-UHFFFAOYSA-N 1-benzylpyrrolidine-3-carboxamide Chemical compound C1C(C(=O)N)CCN1CC1=CC=CC=C1 HNAGHMKIPMKKBB-UHFFFAOYSA-N 0.000 description 1
- GIEMHYCMBGELGY-UHFFFAOYSA-N 10-undecen-1-ol Chemical compound OCCCCCCCCCC=C GIEMHYCMBGELGY-UHFFFAOYSA-N 0.000 description 1
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
- RCYIBFNZRWQGNB-UHFFFAOYSA-N 2,6-dimethylheptan-1-ol Chemical compound CC(C)CCCC(C)CO RCYIBFNZRWQGNB-UHFFFAOYSA-N 0.000 description 1
- VZSRBBMJRBPUNF-UHFFFAOYSA-N 2-(2,3-dihydro-1H-inden-2-ylamino)-N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]pyrimidine-5-carboxamide Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C(=O)NCCC(N1CC2=C(CC1)NN=N2)=O VZSRBBMJRBPUNF-UHFFFAOYSA-N 0.000 description 1
- LCPVQAHEFVXVKT-UHFFFAOYSA-N 2-(2,4-difluorophenoxy)pyridin-3-amine Chemical compound NC1=CC=CN=C1OC1=CC=C(F)C=C1F LCPVQAHEFVXVKT-UHFFFAOYSA-N 0.000 description 1
- BHQBQWOZHYUVTL-UHFFFAOYSA-N 2-(3-methylbutoxy)ethylbenzene Chemical compound CC(C)CCOCCC1=CC=CC=C1 BHQBQWOZHYUVTL-UHFFFAOYSA-N 0.000 description 1
- SJWKGDGUQTWDRV-UHFFFAOYSA-N 2-Propenyl heptanoate Chemical compound CCCCCCC(=O)OCC=C SJWKGDGUQTWDRV-UHFFFAOYSA-N 0.000 description 1
- RCSBILYQLVXLJG-UHFFFAOYSA-N 2-Propenyl hexanoate Chemical compound CCCCCC(=O)OCC=C RCSBILYQLVXLJG-UHFFFAOYSA-N 0.000 description 1
- GZFRVDZZXXKIGR-UHFFFAOYSA-N 2-decanoyloxybenzoic acid Chemical compound CCCCCCCCCC(=O)OC1=CC=CC=C1C(O)=O GZFRVDZZXXKIGR-UHFFFAOYSA-N 0.000 description 1
- VMUNAKQXJLHODT-VAWYXSNFSA-N 2-tridecenal Chemical compound CCCCCCCCCC\C=C\C=O VMUNAKQXJLHODT-VAWYXSNFSA-N 0.000 description 1
- DLHQZZUEERVIGQ-UHFFFAOYSA-N 3,7-dimethyl-3-octanol Chemical compound CCC(C)(O)CCCC(C)C DLHQZZUEERVIGQ-UHFFFAOYSA-N 0.000 description 1
- JFTSYAALCNQOKO-UHFFFAOYSA-N 3-(4-ethylphenyl)-2,2-dimethylpropanal Chemical compound CCC1=CC=C(CC(C)(C)C=O)C=C1 JFTSYAALCNQOKO-UHFFFAOYSA-N 0.000 description 1
- NMRPBPVERJPACX-QMMMGPOBSA-N 3-Octanol Natural products CCCCC[C@@H](O)CC NMRPBPVERJPACX-QMMMGPOBSA-N 0.000 description 1
- RHLVCLIPMVJYKS-UHFFFAOYSA-N 3-octanone Chemical compound CCCCCC(=O)CC RHLVCLIPMVJYKS-UHFFFAOYSA-N 0.000 description 1
- RYYXDZDBXNUPOG-UHFFFAOYSA-N 4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine;dihydrochloride Chemical compound Cl.Cl.C1C(N)CCC2=C1SC(N)=N2 RYYXDZDBXNUPOG-UHFFFAOYSA-N 0.000 description 1
- DKKRDMLKVSKFMJ-UHFFFAOYSA-N 4-propan-2-ylcyclohexan-1-ol Chemical compound CC(C)C1CCC(O)CC1 DKKRDMLKVSKFMJ-UHFFFAOYSA-N 0.000 description 1
- WWJLCYHYLZZXBE-UHFFFAOYSA-N 5-chloro-1,3-dihydroindol-2-one Chemical compound ClC1=CC=C2NC(=O)CC2=C1 WWJLCYHYLZZXBE-UHFFFAOYSA-N 0.000 description 1
- QGFSQVPRCWJZQK-UHFFFAOYSA-N 9-Decen-1-ol Chemical compound OCCCCCCCCC=C QGFSQVPRCWJZQK-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- DKPFZGUDAPQIHT-UHFFFAOYSA-N Butyl acetate Natural products CCCCOC(C)=O DKPFZGUDAPQIHT-UHFFFAOYSA-N 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 240000007436 Cananga odorata Species 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 239000005973 Carvone Substances 0.000 description 1
- NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 description 1
- 241000723346 Cinnamomum camphora Species 0.000 description 1
- JOZKFWLRHCDGJA-LLVKDONJSA-N Citronellyl acetate Natural products CC(=O)OCC[C@H](C)CCC=C(C)C JOZKFWLRHCDGJA-LLVKDONJSA-N 0.000 description 1
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 239000004386 Erythritol Substances 0.000 description 1
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- HZPKNSYIDSNZKW-UHFFFAOYSA-N Ethyl 2-methylpentanoate Chemical compound CCCC(C)C(=O)OCC HZPKNSYIDSNZKW-UHFFFAOYSA-N 0.000 description 1
- YIKYNHJUKRTCJL-UHFFFAOYSA-N Ethyl maltol Chemical compound CCC=1OC=CC(=O)C=1O YIKYNHJUKRTCJL-UHFFFAOYSA-N 0.000 description 1
- 239000005770 Eugenol Substances 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 239000005792 Geraniol Substances 0.000 description 1
- GLZPCOQZEFWAFX-YFHOEESVSA-N Geraniol Natural products CC(C)=CCC\C(C)=C/CO GLZPCOQZEFWAFX-YFHOEESVSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- KGEKLUUHTZCSIP-UHFFFAOYSA-N Isobornyl acetate Natural products C1CC2(C)C(OC(=O)C)CC1C2(C)C KGEKLUUHTZCSIP-UHFFFAOYSA-N 0.000 description 1
- JGFBQFKZKSSODQ-UHFFFAOYSA-N Isothiocyanatocyclopropane Chemical compound S=C=NC1CC1 JGFBQFKZKSSODQ-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 235000019501 Lemon oil Nutrition 0.000 description 1
- HYMLWHLQFGRFIY-UHFFFAOYSA-N Maltol Natural products CC1OC=CC(=O)C1=O HYMLWHLQFGRFIY-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
- NFLGAXVYCFJBMK-UHFFFAOYSA-N Menthone Chemical compound CC(C)C1CCC(C)CC1=O NFLGAXVYCFJBMK-UHFFFAOYSA-N 0.000 description 1
- 239000006001 Methyl nonyl ketone Substances 0.000 description 1
- HSHXDCVZWHOWCS-UHFFFAOYSA-N N'-hexadecylthiophene-2-carbohydrazide Chemical compound CCCCCCCCCCCCCCCCNNC(=O)c1cccs1 HSHXDCVZWHOWCS-UHFFFAOYSA-N 0.000 description 1
- GLZPCOQZEFWAFX-JXMROGBWSA-N Nerol Natural products CC(C)=CCC\C(C)=C\CO GLZPCOQZEFWAFX-JXMROGBWSA-N 0.000 description 1
- FQTLCLSUCSAZDY-ATGUSINASA-N Nerolidol Chemical compound CC(C)=CCC\C(C)=C\CC[C@](C)(O)C=C FQTLCLSUCSAZDY-ATGUSINASA-N 0.000 description 1
- 235000019502 Orange oil Nutrition 0.000 description 1
- 241001499740 Plantago alpina Species 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- PXRCIOIWVGAZEP-UHFFFAOYSA-N Primaeres Camphenhydrat Natural products C1CC2C(O)(C)C(C)(C)C1C2 PXRCIOIWVGAZEP-UHFFFAOYSA-N 0.000 description 1
- UVMRYBDEERADNV-UHFFFAOYSA-N Pseudoeugenol Natural products COC1=CC(C(C)=C)=CC=C1O UVMRYBDEERADNV-UHFFFAOYSA-N 0.000 description 1
- GPMLJOOQCIHFET-UHFFFAOYSA-N Rhubafuran Chemical compound C1OC(C)CC1(C)C1=CC=CC=C1 GPMLJOOQCIHFET-UHFFFAOYSA-N 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- 229910021536 Zeolite Inorganic materials 0.000 description 1
- 239000001940 [(1R,4S,6R)-1,7,7-trimethyl-6-bicyclo[2.2.1]heptanyl] acetate Substances 0.000 description 1
- UAOKXEHOENRFMP-ZJIFWQFVSA-N [(2r,3r,4s,5r)-2,3,4,5-tetraacetyloxy-6-oxohexyl] acetate Chemical compound CC(=O)OC[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](OC(C)=O)C=O UAOKXEHOENRFMP-ZJIFWQFVSA-N 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000001361 adipic acid Substances 0.000 description 1
- 235000011037 adipic acid Nutrition 0.000 description 1
- XCPQUQHBVVXMRQ-UHFFFAOYSA-N alpha-Fenchene Natural products C1CC2C(=C)CC1C2(C)C XCPQUQHBVVXMRQ-UHFFFAOYSA-N 0.000 description 1
- MVNCAPSFBDBCGF-UHFFFAOYSA-N alpha-pinene Natural products CC1=CCC23C1CC2C3(C)C MVNCAPSFBDBCGF-UHFFFAOYSA-N 0.000 description 1
- WUOACPNHFRMFPN-UHFFFAOYSA-N alpha-terpineol Chemical compound CC1=CCC(C(C)(C)O)CC1 WUOACPNHFRMFPN-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- WMGSQTMJHBYJMQ-UHFFFAOYSA-N aluminum;magnesium;silicate Chemical compound [Mg+2].[Al+3].[O-][Si]([O-])([O-])[O-] WMGSQTMJHBYJMQ-UHFFFAOYSA-N 0.000 description 1
- 229910001870 ammonium persulfate Inorganic materials 0.000 description 1
- 239000002280 amphoteric surfactant Substances 0.000 description 1
- 229940011037 anethole Drugs 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 239000003945 anionic surfactant Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 229910052788 barium Inorganic materials 0.000 description 1
- DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 description 1
- ZCHPOKZMTJTNHI-UHFFFAOYSA-L barium(2+);sulfonatooxy sulfate Chemical compound [Ba+2].[O-]S(=O)(=O)OOS([O-])(=O)=O ZCHPOKZMTJTNHI-UHFFFAOYSA-L 0.000 description 1
- 238000003287 bathing Methods 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- JGQFVRIQXUFPAH-UHFFFAOYSA-N beta-citronellol Natural products OCCC(C)CCCC(C)=C JGQFVRIQXUFPAH-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
- OBNCKNCVKJNDBV-UHFFFAOYSA-N butanoic acid ethyl ester Natural products CCCC(=O)OCC OBNCKNCVKJNDBV-UHFFFAOYSA-N 0.000 description 1
- 229940043232 butyl acetate Drugs 0.000 description 1
- PWLNAUNEAKQYLH-UHFFFAOYSA-N butyric acid octyl ester Natural products CCCCCCCCOC(=O)CCC PWLNAUNEAKQYLH-UHFFFAOYSA-N 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 239000000378 calcium silicate Substances 0.000 description 1
- 229910052918 calcium silicate Inorganic materials 0.000 description 1
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
- 239000008116 calcium stearate Substances 0.000 description 1
- 235000013539 calcium stearate Nutrition 0.000 description 1
- OYACROKNLOSFPA-UHFFFAOYSA-N calcium;dioxido(oxo)silane Chemical compound [Ca+2].[O-][Si]([O-])=O OYACROKNLOSFPA-UHFFFAOYSA-N 0.000 description 1
- 229930006739 camphene Natural products 0.000 description 1
- ZYPYEBYNXWUCEA-UHFFFAOYSA-N camphenilone Natural products C1CC2C(=O)C(C)(C)C1C2 ZYPYEBYNXWUCEA-UHFFFAOYSA-N 0.000 description 1
- 229930008380 camphor Natural products 0.000 description 1
- 229960000846 camphor Drugs 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 239000003093 cationic surfactant Substances 0.000 description 1
- 239000010627 cedar oil Substances 0.000 description 1
- SVURIXNDRWRAFU-OGMFBOKVSA-N cedrol Chemical compound C1[C@]23[C@H](C)CC[C@H]3C(C)(C)[C@@H]1[C@@](O)(C)CC2 SVURIXNDRWRAFU-OGMFBOKVSA-N 0.000 description 1
- 229940026455 cedrol Drugs 0.000 description 1
- PCROEXHGMUJCDB-UHFFFAOYSA-N cedrol Natural products CC1CCC2C(C)(C)C3CC(C)(O)CC12C3 PCROEXHGMUJCDB-UHFFFAOYSA-N 0.000 description 1
- 239000001507 cistus ladaniferus l. oil Substances 0.000 description 1
- 239000010632 citronella oil Substances 0.000 description 1
- 229930003633 citronellal Natural products 0.000 description 1
- 235000000983 citronellal Nutrition 0.000 description 1
- 235000000484 citronellol Nutrition 0.000 description 1
- 239000001926 citrus aurantium l. subsp. bergamia wright et arn. oil Substances 0.000 description 1
- 239000004927 clay Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000010634 clove oil Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 239000000306 component Substances 0.000 description 1
- 238000000748 compression moulding Methods 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- BLBJUGKATXCWET-UHFFFAOYSA-N cyclaprop Chemical compound C12CC=CC2C2CC(OC(=O)CC)C1C2 BLBJUGKATXCWET-UHFFFAOYSA-N 0.000 description 1
- VSSAZBXXNIABDN-UHFFFAOYSA-N cyclohexylmethanol Chemical compound OCC1CCCCC1 VSSAZBXXNIABDN-UHFFFAOYSA-N 0.000 description 1
- 239000001941 cymbopogon citratus dc and cymbopogon flexuosus oil Substances 0.000 description 1
- KSMVZQYAVGTKIV-UHFFFAOYSA-N decanal Chemical compound CCCCCCCCCC=O KSMVZQYAVGTKIV-UHFFFAOYSA-N 0.000 description 1
- SQIFACVGCPWBQZ-UHFFFAOYSA-N delta-terpineol Natural products CC(C)(O)C1CCC(=C)CC1 SQIFACVGCPWBQZ-UHFFFAOYSA-N 0.000 description 1
- 239000002781 deodorant agent Substances 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- VTIIJXUACCWYHX-UHFFFAOYSA-L disodium;carboxylatooxy carbonate Chemical compound [Na+].[Na+].[O-]C(=O)OOC([O-])=O VTIIJXUACCWYHX-UHFFFAOYSA-L 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 1
- 235000019414 erythritol Nutrition 0.000 description 1
- 229940009714 erythritol Drugs 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 239000001813 ethyl (2R)-2-methylbutanoate Substances 0.000 description 1
- 229940090910 ethyl 2-methylbutyrate Drugs 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 229940093503 ethyl maltol Drugs 0.000 description 1
- DEFVIWRASFVYLL-UHFFFAOYSA-N ethylene glycol bis(2-aminoethyl)tetraacetic acid Chemical compound OC(=O)CN(CC(O)=O)CCOCCOCCN(CC(O)=O)CC(O)=O DEFVIWRASFVYLL-UHFFFAOYSA-N 0.000 description 1
- OUDSFQBUEBFSPS-UHFFFAOYSA-N ethylenediaminetriacetic acid Chemical compound OC(=O)CNCCN(CC(O)=O)CC(O)=O OUDSFQBUEBFSPS-UHFFFAOYSA-N 0.000 description 1
- 239000010642 eucalyptus oil Substances 0.000 description 1
- 229940044949 eucalyptus oil Drugs 0.000 description 1
- 229960002217 eugenol Drugs 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 229930006735 fenchone Natural products 0.000 description 1
- 239000004872 foam stabilizing agent Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- HIGQPQRQIQDZMP-UHFFFAOYSA-N geranil acetate Natural products CC(C)=CCCC(C)=CCOC(C)=O HIGQPQRQIQDZMP-UHFFFAOYSA-N 0.000 description 1
- 229940113087 geraniol Drugs 0.000 description 1
- 239000010648 geranium oil Substances 0.000 description 1
- 235000019717 geranium oil Nutrition 0.000 description 1
- HIGQPQRQIQDZMP-DHZHZOJOSA-N geranyl acetate Chemical compound CC(C)=CCC\C(C)=C\COC(C)=O HIGQPQRQIQDZMP-DHZHZOJOSA-N 0.000 description 1
- HNZUNIKWNYHEJJ-UHFFFAOYSA-N geranyl acetone Natural products CC(C)=CCCC(C)=CCCC(C)=O HNZUNIKWNYHEJJ-UHFFFAOYSA-N 0.000 description 1
- HNZUNIKWNYHEJJ-FMIVXFBMSA-N geranyl acetone Chemical compound CC(C)=CCC\C(C)=C\CCC(C)=O HNZUNIKWNYHEJJ-FMIVXFBMSA-N 0.000 description 1
- 239000000174 gluconic acid Substances 0.000 description 1
- 235000012208 gluconic acid Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 229960001031 glucose Drugs 0.000 description 1
- 235000001727 glucose Nutrition 0.000 description 1
- CATSNJVOTSVZJV-UHFFFAOYSA-N heptan-2-one Chemical compound CCCCCC(C)=O CATSNJVOTSVZJV-UHFFFAOYSA-N 0.000 description 1
- FXHGMKSSBGDXIY-UHFFFAOYSA-N heptanal Chemical compound CCCCCCC=O FXHGMKSSBGDXIY-UHFFFAOYSA-N 0.000 description 1
- UFLHIIWVXFIJGU-UHFFFAOYSA-N hex-3-en-1-ol Natural products CCC=CCCO UFLHIIWVXFIJGU-UHFFFAOYSA-N 0.000 description 1
- JARKCYVAAOWBJS-UHFFFAOYSA-N hexanal Chemical compound CCCCCC=O JARKCYVAAOWBJS-UHFFFAOYSA-N 0.000 description 1
- FUZZWVXGSFPDMH-UHFFFAOYSA-M hexanoate Chemical compound CCCCCC([O-])=O FUZZWVXGSFPDMH-UHFFFAOYSA-M 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- GFAZHVHNLUBROE-UHFFFAOYSA-N hydroxymethyl propionaldehyde Natural products CCC(=O)CO GFAZHVHNLUBROE-UHFFFAOYSA-N 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- 229940117955 isoamyl acetate Drugs 0.000 description 1
- 239000010656 jasmine oil Substances 0.000 description 1
- SVURIXNDRWRAFU-UHFFFAOYSA-N juniperanol Natural products C1C23C(C)CCC3C(C)(C)C1C(O)(C)CC2 SVURIXNDRWRAFU-UHFFFAOYSA-N 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 229960001375 lactose Drugs 0.000 description 1
- 239000000171 lavandula angustifolia l. flower oil Substances 0.000 description 1
- 239000010501 lemon oil Substances 0.000 description 1
- 235000001510 limonene Nutrition 0.000 description 1
- 229940087305 limonene Drugs 0.000 description 1
- UWKAYLJWKGQEPM-UHFFFAOYSA-N linalool acetate Natural products CC(C)=CCCC(C)(C=C)OC(C)=O UWKAYLJWKGQEPM-UHFFFAOYSA-N 0.000 description 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
- 239000001095 magnesium carbonate Substances 0.000 description 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
- 229910001629 magnesium chloride Inorganic materials 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 239000000845 maltitol Substances 0.000 description 1
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 1
- 235000010449 maltitol Nutrition 0.000 description 1
- 229940035436 maltitol Drugs 0.000 description 1
- 229940043353 maltol Drugs 0.000 description 1
- 229960002160 maltose Drugs 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000001525 mentha piperita l. herb oil Substances 0.000 description 1
- 229930007503 menthone Natural products 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- HRGPYCVTDOECMG-RHBQXOTJSA-N methyl cedryl ether Chemical compound C1[C@@]23[C@H](C)CC[C@H]2C(C)(C)[C@]1([H])[C@@](OC)(C)CC3 HRGPYCVTDOECMG-RHBQXOTJSA-N 0.000 description 1
- JPTOCTSNXXKSSN-UHFFFAOYSA-N methylheptenone Chemical compound CCCC=CC(=O)CC JPTOCTSNXXKSSN-UHFFFAOYSA-N 0.000 description 1
- 239000010445 mica Substances 0.000 description 1
- 229910052618 mica group Inorganic materials 0.000 description 1
- 239000008368 mint flavor Substances 0.000 description 1
- 239000003607 modifier Substances 0.000 description 1
- XONPDZSGENTBNJ-UHFFFAOYSA-N molecular hydrogen;sodium Chemical compound [Na].[H][H] XONPDZSGENTBNJ-UHFFFAOYSA-N 0.000 description 1
- 229930008383 myrcenol Natural products 0.000 description 1
- DUNCVNHORHNONW-UHFFFAOYSA-N myrcenol Chemical compound CC(C)(O)CCCC(=C)C=C DUNCVNHORHNONW-UHFFFAOYSA-N 0.000 description 1
- UUIQMZJEGPQKFD-UHFFFAOYSA-N n-butyric acid methyl ester Natural products CCCC(=O)OC UUIQMZJEGPQKFD-UHFFFAOYSA-N 0.000 description 1
- WASNIKZYIWZQIP-AWEZNQCLSA-N nerolidol Natural products CC(=CCCC(=CCC[C@@H](O)C=C)C)C WASNIKZYIWZQIP-AWEZNQCLSA-N 0.000 description 1
- MGFYIUFZLHCRTH-UHFFFAOYSA-N nitrilotriacetic acid Chemical compound OC(=O)CN(CC(O)=O)CC(O)=O MGFYIUFZLHCRTH-UHFFFAOYSA-N 0.000 description 1
- GYHFUZHODSMOHU-UHFFFAOYSA-N nonanal Chemical compound CCCCCCCCC=O GYHFUZHODSMOHU-UHFFFAOYSA-N 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 239000010502 orange oil Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- QNGNSVIICDLXHT-UHFFFAOYSA-N para-ethylbenzaldehyde Natural products CCC1=CC=C(C=O)C=C1 QNGNSVIICDLXHT-UHFFFAOYSA-N 0.000 description 1
- RUVINXPYWBROJD-UHFFFAOYSA-N para-methoxyphenyl Natural products COC1=CC=C(C=CC)C=C1 RUVINXPYWBROJD-UHFFFAOYSA-N 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 235000019477 peppermint oil Nutrition 0.000 description 1
- WRMXOVHLRUVREB-UHFFFAOYSA-N phosphono phosphate;tributylazanium Chemical compound OP(O)(=O)OP([O-])([O-])=O.CCCC[NH+](CCCC)CCCC.CCCC[NH+](CCCC)CCCC WRMXOVHLRUVREB-UHFFFAOYSA-N 0.000 description 1
- XUWHAWMETYGRKB-UHFFFAOYSA-N piperidin-2-one Chemical compound O=C1CCCCN1 XUWHAWMETYGRKB-UHFFFAOYSA-N 0.000 description 1
- 239000001738 pogostemon cablin oil Substances 0.000 description 1
- 229920000137 polyphosphoric acid Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 235000015497 potassium bicarbonate Nutrition 0.000 description 1
- 229910000028 potassium bicarbonate Inorganic materials 0.000 description 1
- 239000011736 potassium bicarbonate Substances 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 235000011181 potassium carbonates Nutrition 0.000 description 1
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- GRWFGVWFFZKLTI-UHFFFAOYSA-N rac-alpha-Pinene Natural products CC1=CCC2C(C)(C)C1C2 GRWFGVWFFZKLTI-UHFFFAOYSA-N 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 229930007790 rose oxide Natural products 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 239000010671 sandalwood oil Substances 0.000 description 1
- 235000015424 sodium Nutrition 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 1
- RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 description 1
- 239000012418 sodium perborate tetrahydrate Substances 0.000 description 1
- 229940045872 sodium percarbonate Drugs 0.000 description 1
- CHQMHPLRPQMAMX-UHFFFAOYSA-L sodium persulfate Substances [Na+].[Na+].[O-]S(=O)(=O)OOS([O-])(=O)=O CHQMHPLRPQMAMX-UHFFFAOYSA-L 0.000 description 1
- 229910000031 sodium sesquicarbonate Inorganic materials 0.000 description 1
- 235000018341 sodium sesquicarbonate Nutrition 0.000 description 1
- IBDSNZLUHYKHQP-UHFFFAOYSA-N sodium;3-oxidodioxaborirane;tetrahydrate Chemical compound O.O.O.O.[Na+].[O-]B1OO1 IBDSNZLUHYKHQP-UHFFFAOYSA-N 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 229940032147 starch Drugs 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229940116411 terpineol Drugs 0.000 description 1
- 235000019818 tetrasodium diphosphate Nutrition 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- WCTAGTRAWPDFQO-UHFFFAOYSA-K trisodium;hydrogen carbonate;carbonate Chemical compound [Na+].[Na+].[Na+].OC([O-])=O.[O-]C([O-])=O WCTAGTRAWPDFQO-UHFFFAOYSA-K 0.000 description 1
- KYWIYKKSMDLRDC-UHFFFAOYSA-N undecan-2-one Chemical compound CCCCCCCCCC(C)=O KYWIYKKSMDLRDC-UHFFFAOYSA-N 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 239000010679 vetiver oil Substances 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 230000003313 weakening effect Effects 0.000 description 1
- 238000004383 yellowing Methods 0.000 description 1
- 239000010457 zeolite Substances 0.000 description 1
Landscapes
- Detergent Compositions (AREA)
Description
本発明は、発泡錠剤及びその製造方法に関する。 The present invention relates to an effervescent tablet and a method for producing the same.
従来、発泡錠剤が知られており、通常、発泡錠剤は水に投入して二酸化炭素を発生させて使用される。しかしながら、発泡錠剤は吸湿して潮解しやすいといった特性を有することから、使用前まで発泡錠剤を水等の液体から遠ざけておくことが望ましい。 2. Description of the Related Art Conventionally, effervescent tablets are known, and effervescent tablets are generally used by being poured into water to generate carbon dioxide. However, since the effervescent tablet has a characteristic of easily deliquescent by absorbing moisture, it is desirable to keep the effervescent tablet away from a liquid such as water before use.
また、発泡錠剤は、通常、各成分の混合物を打錠機で圧縮成形等することにより製造されるが、打錠時に、混合物の一部が杵に付着してスティッキングが生じ、これにより発泡錠剤の一部が破損するといった問題がある（特許文献１）。特に、香料を含有する発泡錠剤は、発泡錠剤を構成する粉体同士の結合力の弱化に起因してスティッキングが一層生じやすくなる。 In addition, effervescent tablets are usually manufactured by compression-molding a mixture of each component using a tableting machine.At the time of tableting, a part of the mixture adheres to a punch and sticking occurs. There is a problem that a part of the device is damaged (Patent Document 1). In particular, effervescent tablets containing a flavoring are more likely to cause sticking due to weakening of the bonding force between the powders constituting the effervescent tablet.
そこで、香料を含有する発泡錠剤を製造する場合には、このような問題を軽減する目的で、香料を賦形剤にあらかじめ含浸させて、得られた含浸物を他の成分と混合して打錠する方法が一般的に用いられている。しかしながら、発泡錠剤において香料の含有量が多くなると、たとえ香料を賦形剤に含浸させて打錠した場合であってもスティッキングが頻発し、これによって錠剤表面が欠けて良好な外観が得られない、各錠剤の重量にばらつきが生じて一定の品質を保つことが難しくなるといった問題が生じる。また、スティッキングが発生すると、例えば工場において製造作業を一旦停止させて杵に付着した混合物を除去する等の作業が必要になるため、スティッキングの頻発は発泡錠剤の製造効率を著しく悪化させる。 Therefore, when producing effervescent tablets containing a flavor, in order to reduce such problems, the flavor is pre-impregnated with an excipient, and the obtained impregnated material is mixed with other components and punched. A locking method is generally used. However, when the content of the flavor in the effervescent tablet increases, sticking frequently occurs even if the flavor is impregnated with an excipient and tableting is performed, whereby the tablet surface is chipped and a good appearance is not obtained. In addition, there arises a problem that the weight of each tablet varies and it becomes difficult to maintain a constant quality. Further, when sticking occurs, for example, it is necessary to temporarily stop the manufacturing operation in a factory and remove the mixture adhering to the punches. Therefore, the frequent occurrence of sticking significantly deteriorates the manufacturing efficiency of the effervescent tablet.
このため、スティッキングの問題を軽減しながらも、より多くの香料を含有する発泡錠剤を得ることは重要である。 For this reason, it is important to obtain effervescent tablets that contain more flavor while reducing the problem of sticking.
本発明は、スティッキングの問題を軽減しながら、より多くの香料を含有可能な発泡錠剤を提供することを目的とする。 An object of the present invention is to provide an effervescent tablet which can contain more flavor while reducing the problem of sticking.
本発明者らは、前記課題を解決するために鋭意検討を重ねていたところ、炭酸塩及び／又は炭酸水素塩、ならびに有機酸及び／又は無機酸を含有する混合物を打錠して錠剤を形成させ、次いで、得られた錠剤に香料を担持させることによって、香料を含有する発泡錠剤においてスティッキングの問題が抑制できることを見出した。本発明は該知見に基づき更に検討を重ねた結果完成されたものであり、次に掲げるものである。
項１．下記（Ａ）成分及び下記（Ｂ）成分を含有する混合物を打錠して錠剤を形成する第１工程と、該工程により得られた錠剤に下記（Ｃ）成分を担持させる第２工程を含む、下記（Ａ）〜（Ｃ）成分を含有する発泡錠剤の製造方法：
（Ａ）炭酸塩及び／又は炭酸水素塩、
（Ｂ）有機酸及び／又は無機酸、
（Ｃ）香料。
項２．前記発泡錠剤中の香料の含有量が０．１〜１０重量％である、項１に記載の製造方法。
項３．前記発泡錠剤が更に下記（Ｄ）及び／又は下記（Ｅ）成分を含有し、前記第１工程が、前記（Ａ）成分及び（Ｂ）成分ならびに該（Ｄ）及び／又は（Ｅ）成分を含有する混合物を打錠して錠剤を形成する工程である、項１または２に記載の製造方法：
（Ｄ）過硫酸塩及び／又は過硫酸水素塩、
（Ｅ）過ホウ酸塩。
項４．前記第１工程により得られた錠剤がその一部に凹部が形成されているものである、項１〜３のいずれかに記載の製造方法。
項５．項１〜４のいずれかに記載の製造方法により得られる発泡錠剤。
Means for Solving the Problems The inventors of the present invention have made intensive studies in order to solve the above-mentioned problem, and formed a tablet by tableting a mixture containing a carbonate and / or a hydrogen carbonate and an organic acid and / or an inorganic acid. Then, it was found that sticking problems can be suppressed in the effervescent tablet containing the flavor by carrying the flavor on the obtained tablet. The present invention has been completed as a result of further studies based on the findings, and is as follows.
Item 1. It comprises a first step of tableting a mixture containing the following component (A) and the following component (B) to form a tablet, and a second step of supporting the following component (C) on the tablet obtained by the step. And a method for producing an effervescent tablet containing the following components (A) to (C):
(A) carbonate and / or bicarbonate,
(B) an organic acid and / or an inorganic acid,
(C) perfume.
Item 2. Item 2. The production method according to Item 1, wherein the content of the flavor in the effervescent tablet is 0.1 to 10% by weight.
Item 3. The effervescent tablet further contains the following component (D) and / or the following component (E), and the first step comprises the steps of (A) and (B), and (D) and / or (E). Item 1. The production method according to Item 1 or 2, wherein the step comprises tableting the mixture to form tablets.
(D) persulfate and / or hydrogen persulfate,
(E) perborate.
Item 4. Item 4. The method according to any one of Items 1 to 3, wherein the tablet obtained in the first step has a recess formed in a part thereof.
Item 5. Item 7. An effervescent tablet obtained by the production method according to any one of Items 1 to 4.
本発明によれば、スティッキングの問題を軽減しながら、より多くの香料を含有可能な発泡錠剤を得ることができる。 ADVANTAGE OF THE INVENTION According to this invention, the foaming tablet which can contain more flavors can be obtained, reducing the problem of sticking.
本発明は、下記（Ａ）成分及び下記（Ｂ）成分を含有する混合物を打錠して錠剤を形成する第１工程と、該工程により得られた錠剤に下記（Ｃ）成分を担持させる第２工程を含む、下記（Ａ）〜（Ｃ）成分を含有する発泡錠剤の製造方法に関する。また、本発明は、該製造方法により得られた発泡錠剤に関する。
（Ａ）炭酸塩及び／又は炭酸水素塩、
（Ｂ）有機酸及び／又は無機酸、
（Ｃ）香料。
The present invention comprises a first step of tableting a mixture containing the following components (A) and (B) to form a tablet, and a step of supporting the following component (C) on the tablet obtained by the step. The present invention relates to a method for producing a foamed tablet containing the following components (A) to (C), including two steps. The present invention also relates to an effervescent tablet obtained by the production method.
(A) carbonate and / or bicarbonate,
(B) an organic acid and / or an inorganic acid,
(C) perfume.
以下、本発明についてより詳細に説明する。
発泡錠剤
本発明の発泡錠剤は下記（Ａ）〜（Ｃ）成分を含有する。
Hereinafter, the present invention will be described in more detail.
Effervescent Tablet The effervescent tablet of the present invention contains the following components (A) to (C).
本発明において発泡錠剤とは、水中で下記（Ａ）成分と（Ｂ）成分とが反応することによって二酸化炭素を発生する錠剤をいう。 In the present invention, the effervescent tablet refers to a tablet that generates carbon dioxide by reacting the following components (A) and (B) in water.
（Ａ）成分
（Ａ）炭酸塩及び／又は炭酸水素塩として、従来公知の炭酸塩及び／又は炭酸水素塩が挙げられ、本分野において発泡剤の一成分として従来使用されてきた炭酸塩及び／又は炭酸水素塩が好ましく挙げられる。
(A) Component (A) The carbonate and / or bicarbonate includes conventionally known carbonates and / or bicarbonates, and carbonates and / or bicarbonates conventionally used as one component of a foaming agent in the art. Or a hydrogen carbonate is preferably mentioned.
このような炭酸塩として、好ましくは炭酸ナトリウムや炭酸カリウム等の炭酸のアルカリ金属塩、炭酸マグネシウム、炭酸カルシウム等が例示される。炭酸塩は無水物であっても水和物であってもよく、好ましくは無水物である。炭酸塩として、より好ましくは炭酸ナトリウムが例示される。 Preferred examples of such a carbonate include alkali metal salts of carbonic acid such as sodium carbonate and potassium carbonate, magnesium carbonate, calcium carbonate and the like. The carbonate may be an anhydride or a hydrate, and is preferably an anhydride. More preferably, the carbonate is exemplified by sodium carbonate.
また、このような炭酸水素塩として、好ましくは炭酸水素ナトリウムや炭酸水素カリウム等の炭酸水素のアルカリ金属塩が例示され、より好ましくは炭酸水素ナトリウムが例示される。 Further, as such a bicarbonate, an alkali metal bicarbonate such as sodium bicarbonate or potassium bicarbonate is preferably exemplified, and more preferably, sodium bicarbonate is exemplified.
また、このような（Ａ）成分として、セスキ炭酸ナトリウム等の炭酸塩と炭酸水素塩の複塩が例示される。 Examples of the component (A) include a double salt of a carbonate such as sodium sesquicarbonate and a hydrogen carbonate.
これらは１種単独で使用してもよく、２種以上を組み合わせて使用してもよい。 These may be used alone or in combination of two or more.
本発明の発泡錠剤において（Ａ）成分の含有量は、本発明の効果が得られる限り制限されないが、好ましくは５〜５０重量％、より好ましくは１５〜３５重量％が例示される。 The content of the component (A) in the effervescent tablet of the present invention is not limited as long as the effects of the present invention are obtained, but is preferably 5 to 50% by weight, more preferably 15 to 35% by weight.
（Ｂ）成分
（Ｂ）有機酸及び／又は無機酸として、従来公知の有機酸及び／又は無機酸が挙げられ、本分野において発泡剤の一成分として従来使用されてきた有機酸及び／又は無機酸が好ましく挙げられる。
(B) Component (B) The organic acid and / or inorganic acid include conventionally known organic acids and / or inorganic acids, and organic acids and / or inorganic acids conventionally used as one component of a foaming agent in this field. Acids are preferred.
このような有機酸として、好ましくはクエン酸、フマル酸、リンゴ酸、コハク酸、酒石酸、マレイン酸、グルコン酸、サリチル酸、アジピン酸、シュウ酸、マロン酸、グルタン酸、安息香酸等が例示され、より好ましくはクエン酸、フマル酸、リンゴ酸、コハク酸が例示される。 Examples of such organic acids preferably include citric acid, fumaric acid, malic acid, succinic acid, tartaric acid, maleic acid, gluconic acid, salicylic acid, adipic acid, oxalic acid, malonic acid, glutanic acid, and benzoic acid. More preferably, citric acid, fumaric acid, malic acid and succinic acid are exemplified.
また、このような無機酸として、好ましくはスルファミン酸、リン酸等が例示され、より好ましくはスルファミン酸が例示される。 Examples of such an inorganic acid include preferably sulfamic acid and phosphoric acid, and more preferably include sulfamic acid.
これらは１種単独で使用してもよく、２種以上を組み合わせて使用してもよい。 These may be used alone or in combination of two or more.
本発明の発泡錠剤において（Ｂ）成分の含有量は、本発明の効果が得られる限り制限されないが、好ましくは５〜４０重量％、より好ましくは１０〜２５重量％が例示される。 The content of the component (B) in the effervescent tablet of the present invention is not limited as long as the effects of the present invention can be obtained, but is preferably 5 to 40% by weight, more preferably 10 to 25% by weight.
本発明において、前記（Ａ）成分と（Ｂ）成分の含有量は、これらが水中で反応して二酸化炭素を発生できる限り制限されないが、発泡錠剤中、該（Ｂ）成分１重量部に対して前記（Ａ）成分が、好ましくは０．３〜１０重量部、より好ましくは０．３〜５重量部、更に好ましくは０．３〜３重量部が例示される。 In the present invention, the content of the component (A) and the component (B) is not limited as long as they can react with each other in water to generate carbon dioxide. The component (A) is, for example, preferably 0.3 to 10 parts by weight, more preferably 0.3 to 5 parts by weight, and still more preferably 0.3 to 3 parts by weight.
また、本発明において、前記（Ａ）成分と（Ｂ）成分の含有量は、これらが水中で反応して二酸化炭素を発生できる限り制限されないが、発泡錠剤中、該（Ａ）及び（Ｂ）成分の含有量は、これらの合計でより好ましくは１０〜９０重量％、更に好ましくは２５〜５５重量％、特に好ましくは３０〜４５重量％が例示される。 In the present invention, the contents of the components (A) and (B) are not limited as long as they can react in water to generate carbon dioxide. The content of the component is, for example, more preferably 10 to 90% by weight, further preferably 25 to 55% by weight, and particularly preferably 30 to 45% by weight.
（Ｃ）成分
（Ｃ）香料は、用途や趣向性に応じて適宜決定すればよく制限されない。香料として、精油等の天然香料を単独もしくは組み合わせて用いてもよく、合成の単品香料を単独もしくは組み合わせて用いてもよく、また、天然香料と合成香料を任意に組み合わせて調合香料として用いてもよい。
(C) The component (C) fragrance is not limited as long as it is appropriately determined according to the use and taste. As a fragrance, a natural fragrance such as an essential oil may be used alone or in combination, a single synthetic fragrance may be used alone or in combination, or a natural fragrance and a synthetic fragrance may be used in any combination as a compounded fragrance. Good.
本発明を制限するものではないが、天然香料としては、例えば、レモン油、オレンジ油、ベルガモット油、イランイラン油、パチュリ油、シトロネラ油、レモングラス油、ボアドローズ油、チョウジ油、ユーカリ油、セダー油、ラベンダー油、ビャクダン油、ベチバー油、ゼラニウム油、ラブダナム油、ミント油、ペパーミント油、ローズ油、ジャスミン油、リッツアキュベバ油等が挙げられる。 While not limiting the invention, examples of natural flavors include lemon oil, orange oil, bergamot oil, ylang-ylang oil, patchouli oil, citronella oil, lemongrass oil, boad rose oil, clove oil, eucalyptus oil, cedar Oil, lavender oil, sandalwood oil, vetiver oil, geranium oil, labdanum oil, mint oil, peppermint oil, rose oil, jasmine oil, ritz acubeba oil and the like.
また、本発明を制限するものではないが、合成の単品香料としては例えば次の香料が例示される。 Further, the present invention is not limited thereto, but examples of the synthetic perfume include the following perfumes.
炭化水素系香料として、例えば、リモネン、α−ピネン、カンフェン、ｐ−サイメン、フェンチェン等が挙げられる。 Examples of the hydrocarbon-based fragrance include limonene, α-pinene, camphene, p-cymene, and Fenchen.
エーテル系香料として、例えば、テトラヒドロ−２，４−ジメチル−４−フェニルフラン、１，８−シネオール、ローズオキサイド、セドロールメチルエーテル（セドランバー）、ｐ−クレジルメチルエーテル、イソアミルフエェニルエチルエーテル、４−フェニル−２，４，６−トリメチル−１，３−ジオキサン、アネトール等が挙げられる。 Examples of ether-based fragrances include tetrahydro-2,4-dimethyl-4-phenylfuran, 1,8-cineole, rose oxide, cedrol methyl ether (cedrum bar), p-cresyl methyl ether, isoamylphenyl ethyl ether, -Phenyl-2,4,6-trimethyl-1,3-dioxane, anethole and the like.
エステル系香料として、例えば、ゲラニルアセテート、エチルアセテート、エチルプロピオネート、メチルブチレート、エチルイソブチレート、エチルブチレート、ブチルアセテート、エチル２−メチルブチレート、イソアミルアセテート、エチル２−メチルペンタノエート（マンザネート）、ヘキシルアセテート、アリルヘキサノエート、トリシクロデセニルプロピオネート（ＶＥＲＴＯＰＲＯ；フロロシクレン）、アリルヘプタノエート、イソボルニルアセテート、リナリルアセテート、シトロネリルアセテート、２−ｔｅｒ−ブチルシクロヘキシルアセテート（ナルシドール）等が挙げられる。 As ester-based flavors, for example, geranyl acetate, ethyl acetate, ethyl propionate, methyl butyrate, ethyl isobutyrate, ethyl butyrate, butyl acetate, ethyl 2-methyl butyrate, isoamyl acetate, ethyl 2-methyl pentano Ethate (manzanate), hexyl acetate, allyl hexanoate, tricyclodecenyl propionate (VERTOPRO; fluorocyclene), allyl heptanoate, isobornyl acetate, linalyl acetate, citronellyl acetate, 2-tert-butylcyclohexyl Acetate (narcidol) and the like.
アルコール系香料として、例えば、リナノール、３−オクタノール、２，６−ジメチル−ヘプタノール、１０−ウンデセノール、ゲラニオール、ネロール、シトロネロール、ロジノール、ミルセノール、テトラヒドロリナロール、ターピネオール、セドロール、２，４−ジメチル−３−シクロヘキサン−１−メタノール、４−イソプロピルシクロヘキサノール、ネロリドール、９−デセノール、シス−３−ヘキセノール、トランス−２−ヘキセノール、オイゲノール等が挙げられる。 Examples of alcohol-based flavors include linanol, 3-octanol, 2,6-dimethyl-heptanol, 10-undecenol, geraniol, nerol, citronellol, rosinol, myrcenol, tetrahydrolinalool, terpineol, cedrol, and 2,4-dimethyl-3-. Examples thereof include cyclohexane-1-methanol, 4-isopropylcyclohexanol, nerolidol, 9-decenol, cis-3-hexenol, trans-2-hexenol, and eugenol.
アルデヒド系香料として、例えば、シトロネラール、オクタナール、パラアルデハイド、ベンズアルデヒド、アルデヒドＣ−６、アルデヒドＣ−７、アルデヒドＣ−８、アルデヒドＣ−９、アルデヒドＣ−１０、トリプラール、ｐ−エチルジメチルヒドロシンナミックアルデヒド（フローラゾン）、２−トリデセナール、アルデヒドＣ１１等が挙げられる。 Examples of the aldehyde-based fragrance include citronellal, octanal, paraaldehyde, benzaldehyde, aldehyde C-6, aldehyde C-7, aldehyde C-8, aldehyde C-9, aldehyde C-10, tripral, and p-ethyldimethylhydrocinamic. Aldehyde (florazone), 2-tridecenal, aldehyde C11 and the like can be mentioned.
ケトン系香料として、例えば、１−（５，５−ジメチル−１−シクロヘキセン-１-イル）−４−ペンテン−１−オン、アセトイン、メチルアミルケトン、エチルアミルケトン、メチルヘキシルケトン、メチルノニルケトン、メチルヘプテノン、コアボン、カンファー、カルボン、メントン、ｄ−プレゴン、ピペリトン、フェンチョン、ゲラニルアセトン、マルトール、エチルマルトール、２，５−ジメチル−４−ヒドロキシフラノン、プリカトン、アセトフェノン、ｐ−メチルアセトフェノン、ベンジルアセトン、ベンジルケトン等が挙げられる。 Examples of ketone-based flavors include 1- (5,5-dimethyl-1-cyclohexen-1-yl) -4-penten-1-one, acetoin, methyl amyl ketone, ethyl amyl ketone, methyl hexyl ketone, and methyl nonyl ketone , Methylheptenone, koabon, camphor, carvone, menthone, d-pulegone, piperidone, fenchone, geranylacetone, maltol, ethylmaltol, 2,5-dimethyl-4-hydroxyfuranone, pricatone, acetophenone, p-methylacetophenone, benzylacetone And benzyl ketone.
香料は液状、固形状等を問わないが、好ましくは液状が例示される。 The fragrance may be liquid, solid, or the like, but is preferably a liquid.
これらは１種単独で使用してもよく、２種以上を組み合わせて使用してもよい。 These may be used alone or in combination of two or more.
本発明の発泡錠剤において（Ｃ）成分の含有量は、本発明の効果が得られる限り制限されず、発泡錠剤中の香料の含有量として、好ましくは０．１〜１０重量％、より好ましくは０．１〜５重量％、更に好ましくは０．３〜４重量％、特に好ましくは０．３５〜３重量％が例示される。 In the effervescent tablet of the present invention, the content of the component (C) is not limited as long as the effects of the present invention are obtained, and is preferably 0.1 to 10% by weight, more preferably, as the content of the flavor in the effervescent tablet. 0.1-5% by weight, more preferably 0.3-4% by weight, particularly preferably 0.35-3% by weight.
なお、本発明では、発泡錠剤に含まれる全ての香料を後述の第２工程で錠剤に担持させてもよく、一部の香料を後述の第１工程で錠剤に含有させて残りの香料を後述の第２工程で錠剤に担持させてもよい。より詳細に、本発明の発泡錠剤が（Ｃ）成分を０．１重量％含有する場合を例に挙げて説明すると、前者の場合は、本発明の発泡錠剤に含有される全香料を後述の第２工程において錠剤に担持させて、発泡錠剤中の香料の含有量を０．１重量％とすればよい。また、後者の場合は、前記第１工程においてスティッキングが生じない程度に一部の香料を混合して錠剤を形成し、得られた錠剤に残りの香料を担持させて、これらの香料の合計量が発泡錠剤中０．１重量％とすればよい。 In the present invention, all flavors contained in the effervescent tablet may be carried on the tablet in the second step described below, and some flavors may be contained in the tablet in the first step described below, and the remaining flavors may be described later. May be carried on the tablet in the second step. More specifically, the case where the effervescent tablet of the present invention contains the component (C) in an amount of 0.1% by weight will be described as an example. In the former case, the whole fragrance contained in the effervescent tablet of the present invention is described below. In the second step, the content of the flavor in the effervescent tablet may be adjusted to 0.1% by weight by supporting the effervescent tablet on the tablet. In the latter case, a part of the fragrance is mixed to such an extent that sticking does not occur in the first step to form a tablet, and the remaining fragrance is carried on the obtained tablet. Should be 0.1% by weight in the effervescent tablet.
その他の成分
本発明の発泡錠剤には、本発明の効果を妨げない範囲で、必要に応じて任意の成分を更に含有してもよい。
Other Ingredients The effervescent tablet of the present invention may further contain an optional ingredient, if necessary, as long as the effects of the present invention are not hindered.
このような任意の成分として（Ｄ）過硫酸塩及び／又は過硫酸水素塩が例示される。本発明の効果を妨げない限り制限されないが、（Ｄ）成分として、過硫酸ナトリウムや過硫酸カリウム等の過硫酸のアルカリ金属塩、過硫酸アンモニウム、過硫酸リチウム、過硫酸バリウム、過硫酸水素ナトリウムや過硫酸水素カリウム等の過硫酸水素アルカリ金属塩、過硫酸水素アンモニウム、過硫酸水素リチウム、過硫酸水素バリウム、これらの水和物等が例示される。（Ｄ）成分として、より好ましくは過硫酸のアルカリ金属塩、過硫酸水素アルカリ金属塩が例示され、更に好ましくは過硫酸カリウム、過硫酸水素カリウムが例示され、特に好ましくは過硫酸・硫酸・五カリウム塩が例示される。これらは１種単独で使用してもよく２種以上を組み合わせて使用してもよい。 Examples of such optional components include (D) persulfate and / or hydrogen persulfate. The component (D) is not limited as long as the effects of the present invention are not impaired, but may be an alkali metal salt of persulfuric acid such as sodium persulfate or potassium persulfate, ammonium persulfate, lithium persulfate, barium persulfate, sodium hydrogen persulfate, Examples thereof include alkali metal hydrogen persulfate such as potassium hydrogen persulfate, ammonium hydrogen persulfate, lithium hydrogen persulfate, barium hydrogen persulfate, and hydrates thereof. As the component (D), more preferred are alkali metal salts of persulfuric acid and alkali metal salts of hydrogen persulfate. More preferred are potassium persulfate and potassium hydrogen persulfate. Examples are potassium salts. These may be used alone or in combination of two or more.
本発明の発泡錠剤において（Ｄ）成分の含有量は、本発明の効果が得られる限り制限されないが、好ましくは５０重量％以下、より好ましくは１２〜４５重量％、更に好ましくは２０〜４５重量％、特に好ましくは２５〜４０重量％が例示される。 The content of the component (D) in the effervescent tablet of the present invention is not limited as long as the effects of the present invention are obtained, but is preferably 50% by weight or less, more preferably 12 to 45% by weight, and still more preferably 20 to 45% by weight. %, Particularly preferably 25 to 40% by weight.
また、任意の成分として（Ｅ）過ホウ酸塩が例示される。本発明の効果を妨げない限り制限されないが、（Ｅ）成分として、過ホウ酸ナトリウムや過ホウ酸カリウム等の過ホウ酸のアルカリ金属塩、過ホウ酸アンモニウム、過ホウ酸ナトリウム一水和物や過ホウ酸ナトリウム四水和物等の過ホウ酸の水和物等が例示される。（Ｅ）成分として、より好ましくは過ホウ酸のアルカリ金属塩、過ホウ酸の水和物が例示され、更に好ましくは過ホウ酸ナトリウム水和物が例示される。これらは１種単独で使用してもよく２種以上を組み合わせて使用してもよい。 In addition, (E) perborate is exemplified as an optional component. The component (E) is not limited as long as the effects of the present invention are not impaired, but may include, as the component (E), an alkali metal salt of perborate such as sodium perborate and potassium perborate, ammonium perborate, and sodium perborate monohydrate And hydrates of perboric acid such as sodium perborate tetrahydrate and the like. As the component (E), an alkali metal perborate and a hydrate of perboric acid are more preferable, and a hydrate of sodium perborate is more preferable. These may be used alone or in combination of two or more.
本発明の発泡錠剤において（Ｅ）成分の含有量は、本発明の効果が得られる限り制限されないが、好ましくは１〜５０重量％、より好ましくは２〜２０重量％、更に好ましくは５〜２０重量％が例示される。 The content of the component (E) in the effervescent tablet of the present invention is not limited as long as the effects of the present invention can be obtained, but is preferably 1 to 50% by weight, more preferably 2 to 20% by weight, and still more preferably 5 to 20% by weight. % By weight.
このほか、任意の成分として、界面活性剤、キレート剤、漂白剤、漂白補助剤、結合剤、滑沢剤、洗浄補助剤、調整剤、酸化剤、酵素、着色剤、抗菌・殺菌剤、防錆剤、発泡安定剤、保存剤、崩壊剤、消臭剤、防腐剤、賦形剤、糖類、ｐＨ調整剤、油性成分、流動化剤、保湿剤、ビタミン類等が例示される。 In addition, as optional components, surfactants, chelating agents, bleaching agents, bleaching aids, binders, lubricants, cleaning aids, modifiers, oxidizing agents, enzymes, coloring agents, antibacterial and bactericidal agents, antibacterial agents Examples include rust agents, foam stabilizers, preservatives, disintegrants, deodorants, preservatives, excipients, sugars, pH adjusters, oily components, fluidizers, humectants, vitamins, and the like.
これらの任意の成分は、１種単独で使用してもよく２種以上を組み合わせて使用してもよい。任意の成分の含有量も目的に応じて適宜設定すればよい。 These optional components may be used alone or in combination of two or more. The content of an arbitrary component may be appropriately set according to the purpose.
例えば界面活性剤として、本発明の効果が損なわれない限り制限されず、従来の発泡剤に使用されるカチオン性、アニオン性、非イオン、両性界面活性剤の別を問わず広く任意のものを用いることができる。これらは１種単独で使用してもよく２種以上を組み合わせて使用してもよい。界面活性剤を用いる場合、発泡錠剤中、界面活性剤は好ましくは０．１〜４重量％、より好ましくは０．５〜３重量％が例示される。 For example, the surfactant is not limited as long as the effects of the present invention are not impaired, and any of cationic, anionic, nonionic and amphoteric surfactants used in conventional foaming agents can be widely used regardless of the surfactant. Can be used. These may be used alone or in combination of two or more. When a surfactant is used, the surfactant is preferably 0.1 to 4% by weight, more preferably 0.5 to 3% by weight in the effervescent tablet.
例えばキレート剤として、本発明の効果が得られる限り制限されず、例えばエチレンジアミン三酢酸及び／またはその塩、エチレンジアミン四酢酸及び／またはその塩、グリコールエーテルジアミン四酢酸及び／またはその塩、ニトリロ三酢酸及び／またはその塩、ポリリン酸及び／またはその塩（例えばピロリン酸四ナトリウム、ピロリン酸二水素ナトリウム等）等が例示される。好ましくは、金属イオンのキレート能力及び環境有害性の観点から、エチレンジアミン四酢酸、その塩が例示される。これらは１種単独で使用してもよく２種以上を組み合わせて使用してもよい。キレート剤を用いる場合、発泡錠剤中、キレート剤は好ましくは１〜５重量％、より好ましくは１〜３重量％が例示される。 For example, the chelating agent is not limited as long as the effects of the present invention can be obtained. Examples thereof include ethylenediaminetriacetic acid and / or a salt thereof, ethylenediaminetetraacetic acid and / or a salt thereof, glycol etherdiaminetetraacetic acid and / or a salt thereof, and nitrilotriacetic acid. And / or salts thereof, polyphosphoric acid and / or salts thereof (eg, tetrasodium pyrophosphate, sodium dihydrogen pyrophosphate, etc.) and the like. Preferably, ethylenediaminetetraacetic acid and salts thereof are exemplified from the viewpoint of the chelating ability of metal ions and environmental harm. These may be used alone or in combination of two or more. When a chelating agent is used, the chelating agent is preferably 1 to 5% by weight, more preferably 1 to 3% by weight in the effervescent tablet.
例えば漂白剤として、本発明の効果が損なわれない限り制限されず、過炭酸ナトリウム、過リン酸ナトリウム、二酸化チオ尿素、過ピロリン酸ナトリウム等が例示される。これらは１種単独で使用してもよく２種以上を組み合わせて使用してもよい。 For example, the bleach is not limited as long as the effects of the present invention are not impaired, and examples thereof include sodium percarbonate, sodium perphosphate, thiourea dioxide, and sodium perpyrophosphate. These may be used alone or in combination of two or more.
例えば漂白補助剤として、テトラアセチルエチレンジアミン、ペンタアセチルグルコース、イナノイルオキシベンゼンスルホン酸、デカノイルオキシ安息香酸等が例示される。これらは１種単独で使用してもよく２種以上を組み合わせて使用してもよい。好ましくは、前記（Ｄ）成分との反応により、即効性の漂白剤である過酢酸を効率良く生成する観点から、テトラアセチルエチレンジアミンが例示される。 For example, examples of the bleaching aid include tetraacetylethylenediamine, pentaacetylglucose, inanoyloxybenzenesulfonic acid, decanoyloxybenzoic acid, and the like. These may be used alone or in combination of two or more. Preferably, from the viewpoint of efficiently producing peracetic acid, which is a quick-acting bleach, by reaction with the component (D), tetraacetylethylenediamine is exemplified.
例えば結合剤として、ポリビニルピロリドン、ポリオキシエチレン（分子量２０，０００〜５００，０００）、ポリエチレングルコール（分子量約１０００〜５０，０００）、カーボワックス（分子量４，０００〜２０，０００）、カルボキシメチルセルロースナトリウム、ヒドロキシプロピルセルロース、ヒドロキシプロピルメチルセルロース、セルロース、ゼラチン、クレー、ソルビトール、マルチトール、エリスリトール、デンプン、グルコース、マルトース、ラクトース等が例示される。これらは１種単独で使用してもよく２種以上を組み合わせて使用してもよい。 For example, as a binder, polyvinylpyrrolidone, polyoxyethylene (molecular weight of 20,000 to 500,000), polyethylene glycol (molecular weight of about 1,000 to 50,000), carbowax (molecular weight of 4,000 to 20,000), carboxymethyl cellulose Examples include sodium, hydroxypropylcellulose, hydroxypropylmethylcellulose, cellulose, gelatin, clay, sorbitol, maltitol, erythritol, starch, glucose, maltose, lactose and the like. These may be used alone or in combination of two or more.
例えば滑沢剤として、ステアリン酸マグネシウム、ステアリン酸カルシウム、ステアリン酸ナトリウム、ショ糖脂肪酸エステル、安息香酸ナトリウム、タルク、パラフィンワックス等が例示される。これらは１種単独で使用してもよく２種以上を組み合わせて使用してもよい。 Examples of the lubricant include magnesium stearate, calcium stearate, sodium stearate, sucrose fatty acid ester, sodium benzoate, talc, paraffin wax and the like. These may be used alone or in combination of two or more.
例えば賦形剤として、二酸化ケイ素、ケイ酸カルシウム、メタケイ酸アルミン酸マグネシウム、結晶セルロース、マイカ、タルク、ソルビトール、ゼオライト等が例示される。これらは１種単独で使用してもよく２種以上を組み合わせて使用してもよい。 Examples of the excipient include silicon dioxide, calcium silicate, magnesium aluminate metasilicate, crystalline cellulose, mica, talc, sorbitol, zeolite and the like. These may be used alone or in combination of two or more.
例えば調整剤として、硫酸ナトリウム、硫酸カルシウム、硫酸マグネシウム、塩化ナトリウム、塩化カルシウム、塩化マグネシウム等が例示される。これらは１種単独で使用してもよく２種以上を組み合わせて使用してもよい。 For example, examples of the adjusting agent include sodium sulfate, calcium sulfate, magnesium sulfate, sodium chloride, calcium chloride, and magnesium chloride. These may be used alone or in combination of two or more.
本発明の発泡錠剤は、後述の第１工程と第２工程を含む製造方法によって製造される。該製造方法によれば、香料を比較的高含有量で含んでいる場合であってもスティッキングを抑制できる。このため、本発明の発泡錠剤は、香料をより多量に含みながらも、錠剤表面の不自然な凸凹や欠けが抑制されて良好な外観を有し、また、各発泡錠剤の重量のばらつきが抑制されている。 The effervescent tablet of the present invention is manufactured by a manufacturing method including a first step and a second step described below. According to the production method, sticking can be suppressed even when the fragrance is contained at a relatively high content. For this reason, the effervescent tablet of the present invention has a good appearance in which unnatural irregularities and chipping on the tablet surface are suppressed, and the unevenness of the weight of each effervescent tablet is suppressed, while containing a larger amount of perfume. Have been.
本発明の発泡錠剤の用途は制限されず、本発明を制限するものではないが、対象物の洗浄及び／または漂白を目的とするもの、入浴剤、錠菓等が例示される。洗浄及び／または漂白の対象物としては、本発明を制限するものではないが、便器、貯水槽、排水管等のパイプ、風呂釜、シンク、食器、水筒、ポット、義歯、洗面、花瓶、洗濯槽等の硬質表面、衣類、寝具、カーテン等の布等が例示され、本発明の発泡錠剤はこれらの対象物表面に付着する汚れ（カビ等による黒ずみ、タンパク質や尿等による黄ばみ、水アカ、ぬめり、油汚れ、食べこぼし等）の洗浄及び／または漂白に使用できる。 The use of the effervescent tablet of the present invention is not limited, and the present invention is not limited thereto. Examples thereof include those intended for washing and / or bleaching of an object, bath salts, tablet confectionery and the like. The objects to be washed and / or bleached are not limited to the present invention, but include toilets, water tanks, drain pipes, and other pipes, bathtubs, sinks, dishes, water bottles, pots, dentures, washbasins, vases, and laundry. Hard surfaces such as tanks, clothes, bedding, cloths such as curtains, etc. are exemplified. The effervescent tablet of the present invention includes dirt (darkening due to mold, yellowing due to protein or urine, water stain) adhered to the surface of these objects. It can be used for washing and / or bleaching of slicks, oil stains, food spills, etc.).
発泡錠剤の使用方法及び使用量は用途に応じて適宜設定すればよい。更に、対象物の洗浄及び／または漂白を目的とする場合は、対象物や汚れの程度等に応じて適宜設定すればよい。 The method and amount of use of the effervescent tablet may be appropriately set according to the application. Further, when the object is to be washed and / or bleached, it may be appropriately set depending on the object, the degree of dirt, and the like.
例えば、水洗であって水たまり部を有する一般的な便器に使用する場合、便器の水たまり部に本発明の発泡錠剤３〜５０ｇ程度を投入して使用することが例示される。また、水洗トイレの貯水槽に使用する場合、インタンク用の発泡錠剤として、貯水槽の水１Ｌに対して発泡錠剤を３ｇ程度以上、より好ましくは５〜２５ｇ程度を投入して使用することが例示される。 For example, in the case of washing with water and using it for a general toilet having a puddle portion, it is exemplified that about 3 to 50 g of the effervescent tablet of the present invention is put into the puddle portion of the toilet and used. In addition, when used in a water tank of a flush toilet, as an effervescent tablet for an in-tank, about 3 g or more, more preferably about 5 to 25 g of an effervescent tablet may be added to 1 L of water in the cistern. Is exemplified.
本発明を制限するものではないが、このように、例えば洗浄及び／または漂白の対象物が、水を蓄えることが可能な構造である場合には（例えば便器、貯水槽、排水管、風呂釜等）、対象物に蓄えられた水に１回もしくは複数回に分けて本発明の発泡錠剤を投入すればよい。また、例えば、対象物が水を蓄えていない構造である場合には、水に対象物の一部または全部を浸漬させて、ここに本発明の発泡錠剤を投入してもよく、あるいは、水に本発明の発泡錠剤を投入して、ここに対象物を浸漬させてもよい。対象物の洗浄及び／または漂白は、本発明の発泡錠剤を入れた水と対象物とを接触させることにより実施される。 Although the present invention is not limited thereto, for example, when the object to be washed and / or bleached has a structure capable of storing water (for example, a toilet bowl, a water tank, a drain pipe, a bath kettle) Etc.), the effervescent tablet of the present invention may be put into the water stored in the object once or divided into a plurality of times. In addition, for example, when the object has a structure that does not store water, a part or the whole of the object may be immersed in water, and the effervescent tablet of the present invention may be added here, or The effervescent tablet of the present invention may be put into the container, and the object may be immersed here. The washing and / or bleaching of the object is carried out by bringing the water containing the effervescent tablet of the present invention into contact with the object.
本発明の発泡錠剤は、水と接触することにより二酸化炭素を発生して崩壊する。本発明の発泡錠剤は発泡性に優れているため、非発泡性錠剤と比較して、比較的短時間であっても洗浄及び／または漂白効果が得られるが、発泡終了後も洗浄及び／または漂白効果が持続または向上するため、洗浄及び／または漂白時間を発泡時間より長時間とするとより効果的である。好ましい洗浄及び／または漂白時間は対象物、汚れの程度、発泡錠剤の使用量等に応じて適宜選択すればよく、例えば発泡錠剤を水と接触させてから２分〜７２時間、好ましくは１０分〜２４時間である。通常、洗浄及び／または漂白後に必要に応じて水等を流して対象物から汚れを除去すればよい。 The effervescent tablet of the present invention generates carbon dioxide upon contact with water and disintegrates. Since the effervescent tablet of the present invention is excellent in effervescence, a washing and / or bleaching effect can be obtained even in a relatively short time as compared with a non-effervescent tablet. Since the bleaching effect is maintained or improved, it is more effective to set the washing and / or bleaching time longer than the foaming time. The preferred washing and / or bleaching time may be appropriately selected depending on the object, the degree of stain, the amount of the effervescent tablet used, and the like. For example, 2 minutes to 72 hours after contacting the effervescent tablet with water, preferably 10 minutes ~ 24 hours. Usually, after washing and / or bleaching, water or the like may be flowed as necessary to remove stains from the object.
また、本発明を制限するものではないが、発泡錠剤が入浴剤である場合、例えば１回もしくは複数回に分けて発泡錠剤を浴槽に投入すればよく、浴槽への水の添加は錠剤投入の前〜後のいずれであってもよい。 Further, the present invention is not limited to this. When the effervescent tablet is a bathing agent, for example, the effervescent tablet may be put into the bathtub once or divided into a plurality of times. Any of before to after may be used.
この場合、水の温度は本発明の効果が得られる限り制限されず、効果的に発泡する観点から、０〜８０℃、より好ましくは５〜４５℃が例示される。 In this case, the temperature of water is not limited as long as the effects of the present invention can be obtained, and from the viewpoint of effective foaming, is exemplified by 0 to 80 ° C, more preferably 5 to 45 ° C.
本発明の発泡錠剤が水に投入された後、水中に発泡錠剤が固形状で認められなくなった際の溶液のｐＨも本発明の効果が得られる限り制限されないが、該溶液のｐＨとして７〜１１が例示される。 After the effervescent tablet of the present invention is poured into water, the pH of the solution when the effervescent tablet is no longer recognized as a solid in water is not limited as long as the effects of the present invention can be obtained. 11 is exemplified.
この限りにおいて本発明の発泡錠剤の大きさ、形状、硬さ等も制限されない。本発明を制限するものではないが、本発明の発泡錠剤は０．５〜１００ｇ／個が例示され、一般消費者の使い勝手の観点から、好ましくは２〜３０ｇ／個が例示される。また、その形状も適宜決定すればよく、その少なくとも一部に凹部が形成されていてもよい。但し、該凹部は、例えば図１及び図２に示すようにスティッキングによるものではない。 The size, shape, hardness and the like of the effervescent tablet of the present invention are not limited as long as this is the case. Although the present invention is not limited thereto, the effervescent tablet of the present invention exemplifies 0.5 to 100 g / piece, and preferably 2 to 30 g / piece from the viewpoint of convenience for general consumers. In addition, the shape may be appropriately determined, and a concave portion may be formed in at least a part thereof. However, the recess is not formed by sticking as shown in FIGS. 1 and 2, for example.
また、本発明の発泡錠剤は、水に投入した際に二酸化炭素を発生して崩壊するものであれば、その硬さも制限されず、例えば、垂直方向の硬度として５〜３０ｋｇｆが例示される。なお、硬度はデジタルフォースゲージ（ＦＧＰ−１００、日本電産シンポ社製）及び電動式横型スタンド（ＦＧＳ−５０ＸＢ−Ｌ 低速用、日本電産シン社製）で測定される。 The hardness of the effervescent tablet of the present invention is not limited as long as it generates carbon dioxide when poured into water and disintegrates. For example, the hardness in the vertical direction is 5 to 30 kgf. The hardness is measured with a digital force gauge (FGP-100, manufactured by Nidec Shinpo) and an electric horizontal stand (FGS-50XB-L for low speed, manufactured by Nidec Shinpo).
発泡錠剤の製造方法
本発明は、下記（Ａ）成分及び下記（Ｂ）成分を含有する混合物を打錠して錠剤を形成する第１工程と、該工程により得られた錠剤に下記（Ｃ）成分を担持させる第２工程を含む、下記（Ａ）〜（Ｃ）成分を含有する発泡錠剤の製造方法を提供する。
（Ａ）炭酸塩及び／又は炭酸水素塩
（Ｂ）有機酸及び／又は無機酸
（Ｃ）香料
該第１工程は、該（Ａ）及び（Ｂ）成分を含有する混合物を打錠して錠剤を形成できる限り制限されない。該（Ａ）及び（Ｂ）成分は前述の通りであり、第１工程で形成される錠剤は、前述の発泡錠剤中の含有量が充足される範囲において該（Ａ）及び（Ｂ）成分を含有する。また、第１工程で形成される錠剤は、必要に応じて前述の任意の成分、また、スティッキングが生じないことを限度として前記（Ｃ）成分の一部、すなわち香料の一部を更に含有してもよい。任意の成分や香料も前述と同様に説明され、前述の発泡錠剤中の各成分の含有量が前記説明の通り充足される範囲において該錠剤に含有される。
The present invention relates to a first step of forming a tablet by tableting a mixture containing the following component (A) and the following component (B), and adding the following (C) to the tablet obtained by the step. Provided is a method for producing an effervescent tablet containing the following components (A) to (C), including a second step of supporting the components.
(A) carbonate and / or bicarbonate (B) organic acid and / or inorganic acid (C) fragrance In the first step, the mixture containing the components (A) and (B) is tabletted to form a tablet. Is not limited as long as it can be formed. The components (A) and (B) are as described above, and the tablet formed in the first step contains the components (A) and (B) as long as the content in the effervescent tablet is satisfied. contains. The tablet formed in the first step further contains, if necessary, the above-mentioned optional components and a part of the above-mentioned component (C), that is, a part of a flavor, as long as sticking does not occur. You may. Optional components and flavors are also described in the same manner as described above, and are contained in the effervescent tablet as long as the content of each component in the effervescent tablet is satisfied as described above.
第１工程では、該（Ａ）及び（Ｂ）成分ならびに前述の任意の成分や香料を必要に応じて混合して打錠すればよい。第一工程で製造される錠剤に香料が含有される場合、香料はそのまま混合して打錠してもよく、従来の方法と同様にあらかじめ賦形剤等に含浸させて、これを他の成分と混合して打錠してもよい。 In the first step, the components (A) and (B) and any of the above-mentioned optional components and flavors may be mixed and compressed as necessary. When the fragrance is contained in the tablet produced in the first step, the fragrance may be mixed as it is and then compressed, and the excipient may be impregnated in advance as in the conventional method, and this may be mixed with other ingredients. And tableting.
打錠は混合成分の全部を直接打錠してもよく、打錠前に混合成分の一部または全部を顆粒状にしてそののちに打錠してもよく、常法に従い打錠すればよい。また、例えば、臼の中に所定量の前記成分を充填し、これを杵で圧縮成形により打錠して錠剤形態とできる。打錠圧は、目的に応じて適宜設定すればよく本発明を制限するものではないが、例えば０．５〜１０トン／ｃｍ２が例示される。 For tableting, the whole of the mixed components may be directly tableted, or some or all of the mixed components may be granulated before tableting and then tableted, or tableting may be performed according to a conventional method. Alternatively, for example, a predetermined amount of the above-mentioned components may be filled in a die, and the resulting mixture may be compressed into a tablet by a punch and formed into a tablet. The tableting pressure may be appropriately set according to the purpose and does not limit the present invention, and is, for example, 0.5 to 10 ton / cm 2 .
第２工程は、このようにして得られた錠剤に前記（Ｃ）成分を担持させる工程であり、この限りにおいて制限されない。該（Ｃ）成分は前述の通りに説明され、前述の含有量を充足する範囲において該（Ｃ）成分が担持される。 The second step is a step of supporting the component (C) on the tablet thus obtained, and is not limited as long as the tablet (C) is carried. The component (C) is explained as described above, and the component (C) is supported in a range satisfying the content described above.
錠剤への（Ｃ）成分の担持方法は、該（Ｃ）成分が錠剤に担持される限り制限されない。本発明を制限するものではないが、例えば前述の香料そのものまたは香料の濃縮物を、第１工程で形成された錠剤に接触させることにより、香料を錠剤に担持させてもよい。また、例えば、前述の香料を、賦形剤、界面活性剤、増粘剤、有機溶媒等の前述の任意の成分とあらかじめ混合し、得られた混合物を第１工程で形成された錠剤に接触させることにより、香料を錠剤に担持させてもよい。また、これらの担持前に、錠剤に目視では確認できない程度の凹凸を付け、該凹凸部に香料そのもの、香料の濃縮物、または前記混合物を接触させることにより、香料を錠剤に担持させてもよい。また、香料そのもの、香料の濃縮物または前記混合物を錠剤と接触させた後に、更に該接触部分に対して空気による加圧及び／または減圧を１回以上行うことにより香料を錠剤に担持させてもよい。また、香料そのもの、香料の濃縮物または前記混合物を錠剤と接触させた後に、更に接触部位に賦形剤等を接触させることにより、香料を錠剤に担持させてもよい。また、錠剤の一部または複数箇所に目視可能な凹部を形成し、該凹部に前述のようにして香料を担持させてもよい。香料は錠剤の１箇所のみに滴下、塗布等してもよく、複数箇所に滴下、塗布等してもよく、錠剤の全体に滴下、塗布等してもよい。また、錠剤を香料に一定時間浸漬させてもよい。また、錠剤を包装する際に、該包装の内面に香料を滴下、塗布等し、該内面と錠剤とを接触させることにより錠剤に香料を担持させてもよい。 The method for supporting the component (C) on the tablet is not limited as long as the component (C) is supported on the tablet. Although the present invention is not limited thereto, the flavor may be carried on the tablet by, for example, bringing the flavor or the concentrate of the flavor into contact with the tablet formed in the first step. In addition, for example, the above-mentioned flavor is preliminarily mixed with the above-mentioned optional components such as an excipient, a surfactant, a thickener, and an organic solvent, and the obtained mixture is brought into contact with the tablet formed in the first step. By doing so, the flavor may be carried on the tablet. Further, before carrying these, the tablet may be loaded with irregularities to the extent that it cannot be visually confirmed, and the flavor may be carried on the tablets by bringing the flavor into contact with the perfume itself, the concentrate of the flavor, or the mixture. . Further, after the flavor itself, the concentrate of the flavor, or the mixture is brought into contact with the tablet, the flavor is carried on the tablet by further performing one or more pressurizations and / or pressure reductions with air on the contact portion. Good. Alternatively, the perfume may be carried on the tablet by bringing the perfume itself, the concentrate of the perfume or the mixture into contact with the tablet, and further contacting an excipient or the like with the contact site. In addition, a visible concave portion may be formed in a part or a plurality of portions of the tablet, and the flavor may be carried in the concave portion as described above. The fragrance may be dropped and applied to only one place of the tablet, may be dropped and applied to a plurality of places, or may be dropped and applied to the whole tablet. Further, the tablet may be immersed in the flavor for a certain period of time. Further, when packing the tablet, the flavor may be carried on the tablet by dropping or applying a flavor on the inner surface of the package and bringing the inner surface into contact with the tablet.
また、本発明において担持は、（Ｃ）成分が錠剤に担持される限り制限されず、第１工程で得られた錠剤の表面に（Ｃ）成分が付着しているだけであってもよく、錠剤内部に（Ｃ）成分が浸透しているだけであってもよく、また、（Ｃ）成分が錠剤表面に付着し且つ内部にも浸透していてもよく、好ましくは、錠剤の少なくとも一部の内部に（Ｃ）成分が浸透している。この観点から好ましくは、前記第２工程は、前記第１工程により得られた錠剤に（Ｃ）成分を含浸させる工程ということができる。また、この限りにおいて、担持させた（Ｃ）成分全てが錠剤内部に浸透していてもよく、担持させた（Ｃ）成分の一部のみが錠剤内部に浸透していてもよい。 Further, in the present invention, the loading is not limited as long as the component (C) is loaded on the tablet, and the component (C) may only be attached to the surface of the tablet obtained in the first step, The component (C) may only penetrate into the tablet, or the component (C) may adhere to the tablet surface and penetrate into the tablet. Preferably, at least a part of the tablet The component (C) has penetrated into the inside of. From this viewpoint, preferably, the second step can be said to be a step of impregnating the tablet obtained in the first step with the component (C). Further, as long as this is the case, all of the carried component (C) may permeate into the tablet, or only a part of the carried component (C) may permeate into the tablet.
そして、本発明において香料は、前述の通り、第２工程において該（Ｃ）成分を錠剤に担持させることによってのみ発泡錠剤に含有させてもよく、前記第１工程において一部の（Ｃ）成分を用いて錠剤を形成し、次いで第２工程において残りの（Ｃ）成分を錠剤に担持させることによって、発泡錠剤に含有させてもよい。 In the present invention, as described above, the flavor may be contained in the effervescent tablet only by supporting the component (C) on the tablet in the second step, and a part of the component (C) may be contained in the first step. May be used to form a tablet, and then the remaining component (C) may be carried on the tablet in the second step so as to be contained in the foamed tablet.
このようにして得られた発泡錠剤は、通常、１錠ずつまたは複数錠ずつ個包装され、使用時に個包装から取り出して使用される。 The effervescent tablet thus obtained is usually individually packaged one tablet or a plurality of tablets, and is taken out of the individual package and used when used.
このような製造方法によれば、香料を比較的高含有量で含んでいる場合であっても、スティッキングを抑制できる。このため、本発明によれば、スティッキングを抑制しながらも、香料をより多量に含有可能な発泡錠剤を製造できる。また、このような製造方法によれば、香料をより多量に含みながらも、錠剤表面の意図しない不自然な凸凹や欠けが抑制されて良好な外観を有しており、また、各発泡錠剤の重量のばらつきが抑制されており、従って一定の品質が保たれた発泡錠剤を製造できる。また、このような製造方法によれば、杵に付着した混合物を除去するといった作業が軽減できるため、香料を含有する発泡錠剤の製造効率を向上できる。 According to such a manufacturing method, sticking can be suppressed even when the fragrance is contained at a relatively high content. For this reason, according to the present invention, it is possible to produce an effervescent tablet that can contain a larger amount of flavor while suppressing sticking. In addition, according to such a production method, while containing a larger amount of fragrance, unintended unnatural irregularities and chipping of the tablet surface are suppressed and have a good appearance, and each of the effervescent tablets Variations in weight are suppressed, so that effervescent tablets with a constant quality can be produced. In addition, according to such a manufacturing method, since the operation of removing the mixture adhering to the punch can be reduced, the manufacturing efficiency of a foamed tablet containing a flavor can be improved.
このように、本発明の製造方法は、従来よりも簡便且つ高効率で優れた発泡錠剤を提供できる。このようにして得られた発泡錠剤は前述の効果を有し、前述の通りに使用される。 As described above, the production method of the present invention can provide an excellent effervescent tablet that is simpler, more efficient, and more efficient than in the past. The effervescent tablet thus obtained has the above-mentioned effects and is used as described above.
以下に実施例を示して本発明をより詳細に説明するが、本発明はこれらに限定されない。 Hereinafter, the present invention will be described in more detail with reference to Examples, but the present invention is not limited thereto.
試験例１
１．発泡錠剤の製造
表１に従い、発泡錠剤（実施例１）、比較発泡錠剤（比較例１）、参考発泡錠剤（参考例１）を製造した。
Test example 1
1. Production of Effervescent Tablets According to Table 1, effervescent tablets (Example 1), comparative effervescent tablets (Comparative Example 1), and reference effervescent tablets (Reference Example 1) were produced.
具体的には、発泡錠剤（実施例１）において、炭酸ナトリウム、スルファミン酸、オキソン、SODIUM PERBORATE MONOHYDRATE、硫酸ナトリウム、テトラアセチルエチレンジアミン、ラウリルスルホ酢酸ナトリウム及びポリエチレングリコールを混合し、次いでステアリン酸マグネシウムを混合した。得られた混合物を円筒状の臼杵に約２５ｇ投入し、油圧ポンプ（面圧９００ｋｇ／ｃｍ２）で上杵を押し下げて、香料が配合されていない円柱状の錠剤を得た。得られた錠剤の上面中心部にミント系香料１を０．２ｇ滴下した後、１０分間放置し、香料が担持された発泡錠剤（実施例１）を製造した。 Specifically, in the effervescent tablet (Example 1), sodium carbonate, sulfamic acid, oxone, SODIUM PERBORATE MONOHYDRATE, sodium sulfate, tetraacetylethylenediamine, sodium lauryl sulfoacetate and polyethylene glycol are mixed, and then magnesium stearate is mixed. did. About 25 g of the obtained mixture was put into a cylindrical die and punch, and the upper punch was pushed down by a hydraulic pump (surface pressure: 900 kg / cm 2 ) to obtain a columnar tablet containing no perfume. 0.2 g of mint flavor 1 was dropped at the center of the upper surface of the obtained tablet, and then allowed to stand for 10 minutes to produce a foamed tablet carrying the flavor (Example 1).
また、比較発泡錠剤（比較例１）において、二酸化珪素にミント系香料１を含浸させて含浸混合物を得た。得られた含浸混合物を、炭酸ナトリウム、スルファミン酸、オキソン、SODIUM PERBORATE MONOHYDRATE、硫酸ナトリウム、テトラアセチルエチレンジアミン、ラウリルスルホ酢酸ナトリウム及びポリエチレングリコールを混合し、次いでステアリン酸マグネシウムを混合した。得られた混合物を円筒状の臼杵に約２５ｇ投入し、前述と同様にして円柱状の比較発泡錠剤（比較例１）を製造した。 In the comparative foamed tablet (Comparative Example 1), silicon dioxide was impregnated with mint-based flavor 1 to obtain an impregnated mixture. The resulting impregnated mixture was mixed with sodium carbonate, sulfamic acid, oxone, SODIUM PERBORATE MONOHYDRATE, sodium sulfate, tetraacetylethylenediamine, sodium lauryl sulfoacetate and polyethylene glycol, and then magnesium stearate. About 25 g of the obtained mixture was put into a cylindrical die and punch, and a columnar comparative foamed tablet (Comparative Example 1) was produced in the same manner as described above.
また、参考発泡錠剤（参考例１）において、炭酸ナトリウム、スルファミン酸、オキソン、SODIUM PERBORATE MONOHYDRATE、硫酸ナトリウム、テトラアセチルエチレンジアミン、ラウリルスルホ酢酸ナトリウム及びポリエチレングリコールを混合し、次いでステアリン酸マグネシウムを混合した。得られた混合物を円筒状の臼杵に約２５ｇ投入し、前述と同様にして円柱状の参考発泡錠剤（参考例１）を製造した。 In the reference effervescent tablet (Reference Example 1), sodium carbonate, sulfamic acid, oxone, SODIUM PERBORATE MONOHYDRATE, sodium sulfate, tetraacetylethylenediamine, sodium lauryl sulfoacetate, and polyethylene glycol were mixed, and then magnesium stearate was mixed. About 25 g of the obtained mixture was put into a cylindrical die and punch, and a columnar reference foamed tablet (Reference Example 1) was produced in the same manner as described above.
２．スティッキング評価
各発泡錠剤におけるスティッキング評価は、前述の油圧ポンプによる打錠後、上下の杵への粉体の付着具合と製造された錠剤の表面の状態とを、目視で観察することにより行った。スティッキングが認められたものをスティッキング「あり」、認められなかったものを「なし」とした。
2. Sticking Evaluation The sticking evaluation of each effervescent tablet was performed by visually observing the state of powder adhesion to the upper and lower punches and the surface condition of the manufactured tablet after tableting with the above-described hydraulic pump. The sticking was recognized as "sticking" when it was recognized, and the sticking was not performed when it was not recognized.
３．結果
結果を表１に示す。
3. Results The results are shown in Table 1.
表１から明らかなように、錠剤を形成した後に香料を担持させた実施例１では、発泡錠剤の製造中にスティッキングは認められなかった。これに対して、従来通り、賦形剤に香料をあらかじめ含浸させてから他の成分と混合し、これを打錠して得た比較例１では、発泡錠剤の製造中にスティッキングが認められた。なお、香料及び賦形剤を用いることなく製造した参考例１では、発泡錠剤の製造中にスティッキングは認められなかった。 As is clear from Table 1, sticking was not observed during the production of the effervescent tablet in Example 1 in which a fragrance was loaded after the tablet was formed. On the other hand, sticking was observed during the production of the effervescent tablet in the comparative example 1 obtained by previously impregnating the excipient with the flavor and then mixing it with other components and compressing the excipient. . In addition, in Reference Example 1 manufactured without using a flavor and an excipient, sticking was not recognized during the manufacture of the effervescent tablet.
このことから、発泡錠剤中の香料の含有量を、従来の方法ではスティッキングが生じる量とした場合であっても、実施例１の製造方法により発泡錠剤を製造することによって、スティッキングの発生を抑制して発泡錠剤を製造することができた。 From this, even if the content of the flavor in the effervescent tablet is set to an amount that causes sticking in the conventional method, the occurrence of sticking is suppressed by manufacturing the effervescent tablet by the manufacturing method of Example 1. To produce effervescent tablets.
また、表１には示さないが、錠剤を形成させた後に、実施例１とは異なる手順で錠剤に香料を担持させた場合であっても（実施例２及び３）、実施例１と同様に、発泡錠剤の製造中にスティッキングは認められなかった。具体的には、実施例２では、実施例１と同様にして錠剤を形成し、その後、該錠剤の表面に設けた凹部全体に同量のミント系香料１をベタ塗りすることによって、錠剤にミント系香料１を担持させた。また、実施例３では、実施例１と同様にして錠剤を形成し、該錠剤の表面の５点にミント系香料１を滴下することによって、錠剤にミント系香料１を担持させた。このように、実施例２及び３において錠剤形成後に香料を担持させることによっても、スティッキングを抑制できた。 Further, although not shown in Table 1, even when a perfume is carried on the tablet in a procedure different from that of Example 1 after forming the tablet (Examples 2 and 3), the same as in Example 1 No sticking was observed during the production of the effervescent tablet. Specifically, in Example 2, a tablet was formed in the same manner as in Example 1, and thereafter the same amount of the mint-based flavor 1 was solid-coated over the entire concave portion provided on the surface of the tablet, whereby the tablet was formed. Mint-based flavor 1 was carried. In Example 3, a tablet was formed in the same manner as in Example 1, and the mint-based flavor 1 was carried on the tablet by dropping the mint-based flavor 1 at five points on the surface of the tablet. As described above, sticking was able to be suppressed by carrying a flavor after tablet formation in Examples 2 and 3.
また、実施例１〜３の発泡錠剤では、錠剤表面の不自然な凸凹や欠けも認められず、良好な形状を有していた。 In addition, the foamed tablets of Examples 1 to 3 had good shapes without any unnatural irregularities or chipping on the tablet surface.
更に、結果には示さないが、実施例１〜３のいずれの発泡錠剤でもパフィングの発生が認められず、また、各発泡錠剤を水に投入した場合の二酸化炭素発生量及び発泡時間についても、十分に実用可能な結果が得られた。 Furthermore, although not shown in the results, no occurrence of puffing was observed in any of the effervescent tablets of Examples 1 to 3, and also regarding the amount of carbon dioxide generated and the foaming time when each effervescent tablet was put into water, Satisfactory practical results were obtained.
なお、パフィングは、製造した発泡錠剤を袋内に密封し、その膨張率を測定、算出することにより評価した。具体的には、発泡錠剤２５ｇをアルミニウムフィルム製の袋（１００ｍｍ×６５ｍｍ）に入れて密封した直後の袋の体積を測定した（密封直後の体積）。その後、５０℃で２週間保存し、保存後の袋の体積を測定し（保存後の体積）、以下の計算式により膨張率を算出した。
膨張率（％）＝｛（保存後の体積）−（密封直後の体積）｝÷（密封直後の体積）×１００
The puffing was evaluated by sealing the manufactured effervescent tablet in a bag, and measuring and calculating the expansion rate. Specifically, the volume of the bag immediately after 25 g of the effervescent tablet was put in an aluminum film bag (100 mm x 65 mm) and sealed (volume immediately after sealing) was measured. Thereafter, the bag was stored at 50 ° C. for 2 weeks, the volume of the bag after storage was measured (the volume after storage), and the expansion coefficient was calculated by the following formula.
Expansion coefficient (%) = {(volume after storage) − (volume immediately after sealing)} (volume immediately after sealing) × 100
発泡時間は、２０００ｍｌのビーカーに４０℃の水２０００ｍｌを入れ、発泡錠剤１個を、発泡錠剤に設けられた凹部が上側になる状態で投入し、５００秒後に、直径１０ｍｍ以上の大きさの溶け残りがないかどうかを目視で観察した。 Foaming time was as follows: 2000 ml of water at 40 ° C. was placed in a 2000 ml beaker, and one effervescent tablet was placed with the concave portion provided on the effervescent tablet facing upward. It was visually observed whether there was any residue.
このことから、実施例１〜３の発泡錠剤は、発泡錠剤として良好に使用できることが分かった。 From this, it was found that the effervescent tablets of Examples 1 to 3 can be favorably used as effervescent tablets.
試験例２
１．発泡錠剤の製造、評価
実施例１において香料の種類及び含有量を代えた以外は、表２に従って前述と同様にして、発泡錠剤（実施例４〜７）を製造、評価した。
Test example 2
1. Production and Evaluation of Effervescent Tablets Effervescent tablets (Examples 4 to 7) were produced and evaluated in the same manner as described above in accordance with Table 2 except that the type and content of the fragrance were changed in Example 1.
２．結果
結果を表２に示す。
2. Results The results are shown in Table 2.
表２から明らかなように、実施例１と同様に、実施例４〜７においても発泡錠剤の製造中にスティッキングは認められなかった。 As is clear from Table 2, sticking was not observed during the production of the effervescent tablets in Examples 4 to 7 as in Example 1.
また、前記実施例２及び３と同様に、実施例４〜６において、それぞれ凹部全体に香料をベタ塗りした実施例８〜１０、それぞれ錠剤の表面の５点に香料を滴下した実施例１１〜１３においても、スティッキングが生じることなく発泡錠剤を製造できた。 Further, similarly to Examples 2 and 3, in Examples 4 to 6, Examples 8 to 10 in which a fragrance was solid-coated on the entire concave portion, and Examples 11 to 11 in which the fragrance was dropped on five points on the surface of the tablet, respectively. In No. 13, effervescent tablets could be produced without sticking.
これらのことから、前述の製造方法によれば、香料の種類や含有量を変更した場合であっても、スティッキングが生じることなく発泡錠剤を製造することができることが分かった。 From these facts, it was found that according to the above-described production method, even when the type and content of the flavor were changed, an effervescent tablet could be produced without sticking.
参考試験例
１．発泡錠剤の製造、評価
表３に従い、比較発泡錠剤（比較例２）、参考発泡錠剤（参考例２）を製造した。該比較発泡錠剤は、従来通り、賦形剤に香料をあらかじめ含浸させて、これを他の成分と混合して製造した発泡錠剤である。一方、該参考発泡錠剤は、香料を用いていない以外は比較例２の比較発泡錠剤と同様にして製造した発泡錠剤であり、賦形剤を他の成分と混合したものである。
Reference test example
1. Production of Effervescent Tablets According to Evaluation Table 3, comparative effervescent tablets (Comparative Example 2) and reference effervescent tablets (Reference Example 2) were produced. The comparative effervescent tablet is an effervescent tablet produced by impregnating an excipient with a flavorant in advance and mixing it with other components. On the other hand, the reference effervescent tablet is an effervescent tablet manufactured in the same manner as the comparative effervescent tablet of Comparative Example 2 except that no flavor is used, and is obtained by mixing an excipient with other components.
具体的には、比較発泡錠剤（比較例２）において、二酸化珪素にミント系香料４を含浸させて含浸混合物を得た。得られた含浸混合物、炭酸ナトリウム、クエン酸、オキソン、SODIUM PERBORATE MONOHYDRATE、ピロリン酸二水素二ナトリウム、アルファオレフィンスルホン酸ナトリウム及びＤ−ソルビトールをレディゲミキサー（株式会社マツボー製）を用いて混合し、次いでステアリン酸マグネシウムを混合した。得られた混合物をロータリー打錠機（株式会社菊水製作所製）で打錠し、１錠あたり２．６５ｇの円柱状の比較発泡錠剤（比較例２）を得た。 Specifically, in the comparative effervescent tablet (Comparative Example 2), silicon dioxide was impregnated with mint-based flavor 4 to obtain an impregnated mixture. The obtained impregnated mixture, sodium carbonate, citric acid, oxone, SODIUM PERBORATE MONOHYDRATE, disodium dihydrogen pyrophosphate, sodium alpha-olefin sulfonate and D-sorbitol were mixed using a Redige mixer (Matsubo Co., Ltd.), Then magnesium stearate was mixed. The resulting mixture was tableted with a rotary tableting machine (manufactured by Kikusui Seisakusho Co., Ltd.) to obtain 2.65 g of a comparative foamed cylindrical tablet (Comparative Example 2) per tablet.
また、参考発泡錠剤（参考例２）において、炭酸ナトリウム、クエン酸、オキソン、SODIUM PERBORATE MONOHYDRATE、ピロリン酸二水素二ナトリウム、アルファオレフィンスルホン酸ナトリウム、Ｄ−ソルビトール及び二酸化珪素をレディゲミキサー（株式会社マツボー製）を用いて混合し、次いでステアリン酸マグネシウムを混合した。得られた混合物をロータリー打錠機（株式会社菊水製作所製）で打錠し、１錠あたり２．６５ｇの円柱の参考発泡錠剤（参考例２）を得た。 In the reference effervescent tablet (Reference Example 2), sodium carbonate, citric acid, oxone, SODIUM PERBORATE MONOHYDRATE, disodium dihydrogen pyrophosphate, sodium alpha-olefin sulfonate, D-sorbitol, and silicon dioxide were mixed with a Loedige mixer (Co., Ltd.). (Matsubo Co., Ltd.) and then magnesium stearate. The obtained mixture was tableted with a rotary tableting machine (manufactured by Kikusui Seisakusho Co., Ltd.) to obtain 2.65 g of a cylindrical reference foamed tablet (Reference Example 2) per tablet.
得られた錠剤について、前述と同様にしてスティッキングについて評価した。 The obtained tablets were evaluated for sticking in the same manner as described above.
２．結果
結果を表３に示す。
2. Results The results are shown in Table 3.
表３に示すように、比較例２の比較発泡錠剤ではスティッキングの発生が認められたのに対して、参考例２の参考発泡錠剤ではスティッキングの発生が認められなかった。このように、従来通り、賦形剤に香料をあらかじめ含浸させて製造した比較発泡錠剤ではスティッキングが発生し、香料を用いることなく賦形剤を混合して製造した発泡錠剤ではスティッキングが発生しなかった。このことから、スティッキングは賦形剤の有無、また、他の成分の有無よりも、香料の有無に影響を受けることが分かった。 As shown in Table 3, sticking occurred in the comparative effervescent tablet of Comparative Example 2, whereas sticking did not occur in the reference effervescent tablet of Reference Example 2. As described above, sticking occurs in the comparative effervescent tablet manufactured by previously impregnating the excipient with the flavor, and sticking does not occur in the effervescent tablet manufactured by mixing the excipient without using the flavor. Was. From this, it was found that sticking was more affected by the presence or absence of the fragrance than by the presence or absence of the excipient and other components.
Claims (3)
（Ａ）炭酸塩及び／又は炭酸水素塩、
（Ｂ）有機酸及び／又は無機酸、
（Ｃ）香料、
（Ｄ）過硫酸塩及び／又は過硫酸水素塩、
（Ｅ）過ホウ酸塩。 A first step of tableting a mixture containing the following components (A ), (B ), (D), and (E) to form a tablet, and loading the following component (C) on the tablet obtained by the step: A method for producing an effervescent tablet containing the following components (A) to ( E ), including a second step of producing the effervescent tablet, wherein the content of the (A) component in the effervescent tablet is 15 to 35% by weight, and (B) The content of the component is 10 to 25% by weight, the content of the component (C) is 0.3 to 10% by weight, the content of the component (D) is 12 to 45% by weight, and the content of the component (E) is 2 -20% by weight :
(A) carbonate and / or bicarbonate,
(B) an organic acid and / or an inorganic acid,
(C) fragrance ,
(D) persulfate and / or hydrogen persulfate,
(E) perborate .
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2015104872A JP6656822B2 (en) | 2015-05-22 | 2015-05-22 | Effervescent tablet and method for producing the same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2015104872A JP6656822B2 (en) | 2015-05-22 | 2015-05-22 | Effervescent tablet and method for producing the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016216652A JP2016216652A (en) | 2016-12-22 |
| JP6656822B2 true JP6656822B2 (en) | 2020-03-04 |
Family
ID=57579949
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015104872A Active JP6656822B2 (en) | 2015-05-22 | 2015-05-22 | Effervescent tablet and method for producing the same |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP6656822B2 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109957468A (en) * | 2017-12-25 | 2019-07-02 | 浙江神英科技有限公司 | A kind of plant laundry effervescent tablet in olive oil source and preparation method thereof |
| JP7189610B2 (en) * | 2019-01-10 | 2022-12-14 | シーバイエス株式会社 | SOLID CLEANING COMPOSITION FOR COOKING EQUIPMENT AND CLEANING METHOD USING THE SAME |
| JP7246091B2 (en) * | 2019-12-05 | 2023-03-27 | 株式会社ヘルスカンパニー | detergent set |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60110800A (en) * | 1983-11-21 | 1985-06-17 | 株式会社エンクラ−ビジネス | Detergent |
| JPH06108099A (en) * | 1992-09-30 | 1994-04-19 | Lion Corp | Tablet detergent composition |
| US6468950B1 (en) * | 1998-04-30 | 2002-10-22 | Kyowa Limited | Denture detergents containing antimicrobial metal ions |
| ES2288998T3 (en) * | 2000-05-17 | 2008-02-01 | Henkel Kommanditgesellschaft Auf Aktien | MOLDED BODIES OF DETERGENTS OR CLEANING PRODUCTS. |
| JP5339672B2 (en) * | 2006-07-03 | 2013-11-13 | 小林製薬株式会社 | Bleach cleaning composition |
-
2015
- 2015-05-22 JP JP2015104872A patent/JP6656822B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2016216652A (en) | 2016-12-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP1034250B1 (en) | Detergent tablet | |
| ES2234127T3 (en) | METHODS TO REDUCE MICROORGANISMS AND COMPOSITIONS TO CLEAN FOOD. | |
| JP6656822B2 (en) | Effervescent tablet and method for producing the same | |
| US20020061831A1 (en) | Effervescent toilet bowl sanitizer tablet | |
| US4540504A (en) | Denture cleaner having improved dissolution time and clarity and method of preparation | |
| JP6664884B2 (en) | Bleaching detergent composition and method for suppressing temperature rise | |
| US11492572B2 (en) | Effervescing compositions and tablets for treating toilets | |
| US4755354A (en) | Bromide activated hypochlorite cleaning of soiled toilet bowls | |
| WO2014024170A1 (en) | Tablet coating | |
| JP2024032791A (en) | Foaming cleaning agent and its usage method | |
| US10920178B2 (en) | Dishwasher detergent fragrance composition | |
| JP7240105B2 (en) | Effervescent composition | |
| US6491947B2 (en) | Expanded perborate salt, use, and method of production | |
| JP2012219012A (en) | Aromatic | |
| US20230071639A1 (en) | Effervescing Compositions and Tablets for Treating Toilets | |
| USRE32771E (en) | Denture cleaner having improved dissolution time and clarity and method of preparation | |
| JP2002513072A (en) | Non-granular detergent products containing bleach activators | |
| JP7149745B2 (en) | Effervescent cleaning tablet | |
| JP2003336098A (en) | Foaming composition | |
| JP2835710B2 (en) | Denture cleaning composition | |
| GB2157705A (en) | Cleaning composition for waste-disposer | |
| JP2010043210A (en) | Foamable cleaning composition | |
| KR20030096491A (en) | Foaming cleaner for a drain-outlet | |
| EP4157979B1 (en) | Tablet | |
| CA1237040A (en) | Disposer cleaner |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20180410 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20190611 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20190730 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20190820 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20191017 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20191218 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20200107 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20200205 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 6656822 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |