JP6625994B2 - Chemical filling device - Google Patents

Description

  The present invention relates to a drug solution filling device for filling a drug solution into a drug solution storage portion of a portable drug solution administration device such as an insulin pump.

  2. Description of the Related Art In recent years, a treatment method for continuously administering a drug solution into a patient's body by a subcutaneous injection, an intravenous injection, or the like has been performed. For example, as a treatment method for a diabetic patient, a treatment for continuously injecting a small amount of insulin into a patient's body has been performed. In this treatment method, in order to administer a drug solution (insulin) to a patient all day, a portable drug solution administration device (so-called insulin pump) that is fixed and portable to a patient's body or clothes is used.

  2. Description of the Related Art As a conventional drug solution administration device, for example, there is one as described in Patent Document 1. The drug solution administration device described in Patent Document 1 has a drug solution storage unit that stores a drug solution, and a piston that is driven in the drug solution storage unit. And a medical solution is administered to a user by a piston pushing out a medical solution from a chemical solution storage part.

  However, in general, when the drug solution delivery device reaches the user, the drug solution is not previously filled in the drug solution storage unit. Therefore, when using the drug solution administration device, the user needs to perform an operation of filling the drug solution storage unit from a drug solution container (for example, a vial) in which a drug solution is separately stored.

  As a conventional method of filling a drug solution storage unit, for example, a user first pours a drug solution from a drug solution container using a syringe. Then, there is a method in which a needle tube of a syringe is punctured into a filling port provided in the drug solution storage unit to fill the drug solution into the drug solution storage unit.

  Further, as another conventional method of filling the chemical solution storage unit, for example, first, the chemical solution storage unit and the chemical solution container are connected using an adapter. Next, there is also a method of pulling a pusher provided in the drug solution storage unit to fill the drug solution in the drug solution container into the drug solution storage unit.

Japanese Patent Publication No. 2010-501283

  However, in the conventional method of filling the chemical storage unit, whether or not the filling is completed is performed by the user visually checking the chemical storage unit. Therefore, when the liquid medicine to be filled in the liquid medicine storage section is a colorless and transparent liquid medicine such as insulin which is difficult to visually recognize, it is difficult to determine whether or not the filling operation of the liquid medicine in the liquid medicine storage section is completed. Had a problem.

  SUMMARY OF THE INVENTION An object of the present invention is to provide a liquid medicine filling apparatus that can easily determine completion of filling of a liquid medicine in a liquid medicine storage section even when the color of the liquid medicine is difficult to see in consideration of the above problems.

  In order to solve the above problems and achieve the object of the present invention, a drug solution filling device of the present invention includes a housing, a mounting portion, a suction-side connection port, and a suction mechanism. The mounting section is provided on the housing, and is mounted with a chemical storage section having a filling port into which the chemical liquid is injected and a liquid sending port for sending out the filled chemical liquid. The suction side connection port communicates with the liquid sending port. The suction mechanism suctions the gas inside the drug solution storage unit via the suction-side connection port. The suction mechanism has a lever member, a suction side pusher, a syringe, and a notification mechanism. The lever member is rotatably provided on the housing. The suction side pusher is operated by a lever member. The syringe is inserted so that the suction side pusher can slide. The notification mechanism notifies that the drug solution storage unit has been filled with the drug solution based on the load applied to the lever member. Then, when the gas in the drug solution storage unit is sucked by the suction mechanism, the drug solution is filled into the drug solution storage unit from the drug solution container connected to the filling port.

  ADVANTAGE OF THE INVENTION According to the chemical | medical-solution filling apparatus of this invention, even if the color of a chemical | medical solution is hard to be seen, completion of filling | filling to a chemical | medical solution storage part can be determined easily.

BRIEF DESCRIPTION OF THE DRAWINGS It is a perspective view which shows the chemical | medical-solution filling apparatus and the chemical | medical-solution filling unit concerning embodiment of this invention. FIG. 2 is an exploded perspective view showing a chemical filling device and a chemical filling unit according to the embodiment of the present invention. It is a front view showing the medical fluid filling device concerning an embodiment of the invention. It is explanatory drawing which shows typically the chemical | medical-solution filling apparatus concerning embodiment of this invention, and the chemical | medical-solution filling operation | movement of a chemical | medical-solution filling unit. It is a front view which shows the chemical | medical solution filling apparatus concerning embodiment of this invention, and operation | movement which fills a chemical | medical solution to the chemical | medical solution storage part of a chemical | medical solution filling unit. FIGS. 6A and 6B show the operation of the notification mechanism of the liquid medicine filling apparatus according to the embodiment of the present invention, in which FIG. 6A is an explanatory diagram showing a state before the lever member 48 is operated, and FIG. FIG. 7A illustrates the operation of the notification mechanism in a state in which the filling of the drug solution in the drug solution filling device according to the embodiment of the present invention is completed, FIG. 7A is an explanatory diagram showing a state before the lever member 48 is operated, and FIG. It is explanatory drawing which shows the state which operated 48. It is explanatory drawing which shows the modification of the alerting | reporting mechanism in the chemical | medical solution filling apparatus concerning embodiment of this invention. It is a block diagram which shows the control system concerning the modification of the alerting | reporting mechanism in the chemical | medical solution filling apparatus concerning embodiment of this invention.

  Hereinafter, an embodiment of a drug solution filling device of the present invention will be described with reference to FIGS. In the drawings, common members are denoted by the same reference numerals. Further, the present invention is not limited to the following embodiments.

<1. Embodiment>
1-1. Configuration Examples of Chemical Filling Device, Chemical Filling Device, and Chemical Filling Adapter First, referring to FIGS. 1 to 3, an embodiment of a chemical filling device, a chemical filling device, and a chemical filling adapter of the present invention (hereinafter, “this example” ") Will be described.
FIG. 1 is a perspective view of the liquid medicine filling device of the present example as viewed from the front, and FIG. 2 is an exploded perspective view showing the liquid medicine filling device, the filling adapter, and the liquid medicine storage device of the present example. In FIGS. 1 and 2, an outer case 61 of the chemical solution storage device 2 described later is shown transparent so as to show a main part of the chemical solution storage device 2.

As shown in FIG. 1, the drug solution filling device 1 is a device for filling a drug solution into a drug solution storage unit 62 of a drug solution storage device 2. The drug solution filling device 1 is provided with a drug solution storage device 2 constituting a drug solution administration device and a filling adapter 3. Note that a filling adapter 3 is attached to the chemical storage device 2 in advance.
The chemical storage unit 2 and the filling adapter 3 constitute a chemical filling unit 5. The chemical filling device 1 and the chemical filling unit 5 mounted on the chemical filling device 1 constitute a chemical filling set 10.

  A vial 4, which is an example of a drug solution container, is attached to the filling adapter 3. The drug solution storage device 2 is integrally combined with a power supply, a drive unit having a drive mechanism for sending a drug solution, and the like to form a drug solution administration device. The drug solution administration device is a portable drug solution administration device for continuously administering a drug solution into a patient's body, such as a patch-type insulin pump, a tube-type insulin pump, and other portable drug solution administration devices. Widely applied.

[Drug filling device]
Next, the chemical filling device 1 will be described with reference to FIGS.
FIG. 3 is a front view showing the chemical liquid filling set 10. FIG. 3 shows a state where the first case 16 of the chemical liquid filling device 1 is removed.

  As shown in FIGS. 1 to 3, the liquid medicine filling apparatus 1 includes a housing 11 constituting an external appearance, a filling amount adjusting mechanism 12 provided in the housing 11, and a suction mechanism 13.

[Housing]
The housing 11 is formed in a substantially rectangular parallelepiped shape with a part cut away, and is formed so as to be grippable by a user. The housing 11 has a first case 16 and a second case 17 overlapping each other.

  The first case 16 has a front portion 16a formed in a substantially rectangular shape, an upper surface portion 16b that is substantially vertically continuous from one longitudinal end of the front portion 16a, and substantially vertically continuous from the other longitudinal end of the front portion 16a. And a mounting surface portion 16c opposed to the upper surface portion 16b. In addition, the first case 16 is connected to a first side surface portion 16d that is substantially vertically continuous from one end in the short direction of the front portion 16a, and is substantially vertically continuous from the other side in the short direction of the front portion 16a. It has a second side face 16e facing the section 16d. And the chemical | medical solution filling apparatus 1 stands by setting the mounting surface part 16c to a desk or a table | surface, and making the longitudinal direction of the housing | casing 11 turn to a perpendicular direction.

  On the other side in the longitudinal direction of the front portion 16a, there is provided a pedestal portion 18 projecting toward both sides in the short direction. The pedestal portion 18 is formed with a substantially circular insertion hole 22.

  Further, a mounting portion 21 is provided above the pedestal portion 18 in the front portion 16a. The mounting part 21 is formed from the front part 16a to the upper part 16b. The mounting portion 21 is recessed from one surface of the front portion 16a in a width direction orthogonal to both the longitudinal direction and the short direction of the front portion 16a. Then, as shown in FIGS. 1 and 2, the liquid filling unit 5 is mounted on the mounting section 21.

  An opening 23 having a substantially square shape and a through-hole 24 are formed in a main surface portion 21a of the mounting portion 21 which is parallel to one surface of the front portion 16a. A positioning groove 26 is provided in the side wall 21b of the mounting portion 21 on the side of the second side surface 16e.

  On one side in the longitudinal direction of the front portion 16a and on the other side opposite to the exposed side, a rotating pin, a first bearing portion, and a second bearing portion (not shown) are provided. A lever member 48 of the suction mechanism 13 described later is rotatably supported by the rotation pin. A feed screw shaft 34 of the filling amount adjusting mechanism 12 described later is rotatably supported by the first bearing portion, and an unillustrated swing of a guide member 37 of the filling amount adjusting mechanism 12 is supported by the second bearing portion. A pin is rotatably supported.

  The upper surface portion 16b is provided with a suction-side connection hole 27 into which a second connection port 74 of the filling adapter 3 described later is inserted. In the suction side connection hole 27, a suction side connection port 55 of the suction mechanism 13 described later is arranged.

  As shown in FIGS. 1 and 2, a lever member 48 of the suction mechanism 13, which will be described later, is disposed on the first side surface 16d.

  The second case 17 is formed in a substantially rectangular flat plate shape, and is disposed on the back side of the housing 11. The second case 17 covers an opening formed by the upper surface portion 16b, the first side surface portion 16d, the second side surface portion 16e, and the mounting surface portion 16c in the first case 16. Further, the other side in the longitudinal direction of the second case 17 projects toward both sides in the lateral direction, similarly to the front portion 16 a of the first case 16.

[Filling amount adjustment mechanism]
Next, the configuration of the filling amount adjusting mechanism 12 will be described.
As shown in FIG. 3, the filling amount adjusting mechanism 12 includes a feed screw shaft 34, an operation unit 35, a movable member 36, a guide member 37, and a hook member 38.

  The feed screw shaft 34 is rotatably supported by a first bearing (not shown) provided in the first case 16. The feed screw shaft 34 is provided with a spirally extending screw groove on the outer peripheral surface thereof. The feed screw shaft 34 is arranged such that its axial direction is along the longitudinal direction of the housing 11. On the other side in the axial direction of the feed screw shaft 34, an operation unit 35 is provided. The operation unit 35 is formed in a substantially disk shape, and is fixed to the feed screw shaft 34. A part of the operation unit 35 is exposed from an operation window (not shown) of the second case 17. Then, when the user rotates the operation unit 35, the feed screw shaft 34 rotates.

  The guide member 37 is formed in a substantially rectangular flat plate shape. A swing pin (not shown) is provided at one end of the guide member 37 in the longitudinal direction. The swing pin of the guide member 37 is rotatably attached to a second bearing (not shown) provided in the first case 16. Thus, the guide member 37 rotates around the swing pin.

  On the other side of the guide member 37 in the longitudinal direction, a bent piece 37a is provided. The release button 42 protrudes from one surface of the bent piece 37a. As shown in FIG. 2, the release button 42 is inserted through the insertion hole 22 of the first case 16. A return spring (not shown) is arranged between the bent piece 37a and the second case 17.

  A guide groove (not shown) is formed between the swing pin and the bent piece 37a in the guide member 37. The guide groove is formed along the longitudinal direction of the guide member 37. Further, an engagement piece 43 is formed between the guide groove of the guide member 37 and the bent piece 37a. The engagement piece 43 projects in the same direction as the release button 42. As shown in FIG. 2, the engagement piece 43 passes through the through hole 24 of the first case 16.

  The movable member 36 is formed in a substantially flat plate shape, and an opening that opens in a substantially square shape is formed at a substantially center thereof. A nut 44 is provided on one side of the movable member 36. The nut 44 engages with the feed screw shaft 34.

A hook member 38 is inserted into the opening of the movable member 36. The hook member 38 has a slide piece (not shown) slidably inserted into the guide groove of the guide member 37 and a hook piece 38a. The hook pieces 38a protrude in the same direction as the engagement pieces 43.
The hook piece 38a is engaged with a nut piece 64c of the drug solution storage device 2 described later.

  When the feed screw shaft 34 is rotated, the rotational force of the feed screw shaft 34 is transmitted to the movable member 36 and the hook member 38 via the nut 44. Then, the movable member 36 and the hook member 38 move along the guide groove of the guide member 37. Thereby, the position of the hook piece 38a can be adjusted.

  The hook member 38 is attached to the guide member 37 via a sliding piece. Therefore, when the guide member 37 rotates, the hook member 38 moves together with the guide member 37.

[Suction mechanism]
Next, the configuration of the suction mechanism 13 will be described.
As shown in FIG. 3, the suction mechanism 13 includes a suction side connection port 55, a suction tube 46, a syringe 47, a lever member 48, a suction side presser 49, a lever member 48 and a suction side presser 49. And a notification mechanism 100 for connecting the

  As shown in FIG. 2, the suction side connection port 55 is disposed in the suction side connection hole 27 provided in the housing 11. As shown in FIG. 3, a suction tube 46, which is an example of a suction passage, is connected to the suction-side connection port 55. One end of the suction tube 46 is connected to the suction-side connection port 55, and the other end of the suction tube 46 is connected to the syringe 47.

  Further, a first check valve 51 is provided in the middle of the suction tube 46. The first check valve 51 is opened only when the gas passing through the suction tube 46 flows from the suction side connection port 55 to the syringe 47, and is closed when the gas flows from the syringe 47 to the suction side connection port 55.

  The syringe 47 is formed in a substantially cylindrical shape. A second check valve 52 is provided at one end of the syringe 47 in the axial direction. The second check valve 52 is opened only when gas is discharged from the syringe 47 to the outside of the apparatus, and is closed when gas is sucked into the syringe 47 from outside except for the suction tube 46. Therefore, only the gas passing through the suction tube 46 is sent into the syringe 47.

  A suction side pusher 49 is slidably inserted in the cylindrical hole of the syringe 47 in the axial direction of the syringe 47. The suction side pusher 49 is for freely adjusting the capacity in the syringe 47. Further, a pressing spring 53 is provided on the suction side pusher 49. The pressing spring 53 is interposed between the suction side presser 49 and the second side surface 16 e of the first case 16. The pressing spring 53 urges the suction-side pusher 49 toward one side of the syringe 47 in the axial direction.

  Further, a lever member 48 is connected to the suction side pusher 49 via a notification mechanism 100. At one end of the lever member 48, a bearing hole 48a is provided. A rotating pin (not shown) provided in the first case 16 passes through the bearing hole 48a. The lever member 48 is rotatably supported by the first case 16 and the second case 17 about a pivot pin. A notification mechanism 100 is rotatably attached to the other end of the lever member 48.

  The notification mechanism 100 includes a first member 101, a second member 102, a first urging spring 103, and a second urging spring 104. One end of the first member 101 is attached to the lever member 48 via a connection pin 101a. The first member 101 has a saw blade-shaped engaging portion 101b formed of a plurality of irregularities along the moving direction of the first member 101. The engaging portion 101b of the first member 101 is movably engaged with the second member 102.

  The second member 102 is rotatably attached to the suction side pusher 49 via the connection pin 102a. The second member 102 has an engaged portion 102b that engages with the engaging portion 101b of the first member 101. The engaged portion 102b is formed in a saw blade shape including a plurality of irregularities along the moving direction of the first member 101. The second member 102 supports the first member 101 movably in a direction approaching and separating from the end on the connection pin 102a side.

  A first biasing spring 103 is interposed between an end of the first member 101 opposite to the connection pin 101a and an end of the second member 102 on the side of the connection pin 102a. The first biasing spring 103 biases the first member 101 in a direction away from the end of the second member 102 on the connection pin 102a side.

  The second biasing spring 104 is interposed between the first member 101 and the second member 102. The second biasing spring 104 is disposed at a position between the first member 101 and the second member 102 on a side opposite to a position where the engaging portion 101b and the engaged portion 102b are engaged. The second biasing spring 104 biases the engaging portion 101b of the first member 101 toward the engaged portion 102b.

  When the user grips the lever member 48, the suction side pusher 49 moves to the other axial side of the syringe 47 together with the first member 101 and the second member 102 of the notification mechanism 100 against the urging force of the pressing spring 53. (See FIGS. 5 and 6B). As a result, the capacity in the syringe 47 is increased, and air is sent into the syringe 47 via the suction-side connection port 55 and the suction tube 46.

  When the user stops the gripping operation of the lever member 48, the suction side pusher 49 is urged by the pressing spring 53 and inserted into the syringe 47. The suction tube 46 is provided with a first check valve 51 that shuts off air flowing from the syringe 47 to the suction-side connection port 55. Therefore, the air in the syringe 47 is discharged to the outside via the second check valve 52. Further, the moving force of the suction side pusher 49 is transmitted to the lever member 48 via the notification mechanism 100, and the lever member 48 returns to the initial state shown in FIG.

[Chemical liquid filling unit]
Next, the chemical liquid filling unit 5 including the chemical liquid storage device 2 and the filling adapter 3 will be described with reference to FIGS.

[Drug storage device]
As shown in FIG. 2, the drug solution storage device 2 includes an outer case 61 having an open surface, a drug solution storage unit 62 housed inside the outer case 61, a storage unit side connection port 63, and a pusher member 64. have.

  The outer case 61 is formed in a container shape with one surface opened. The outer case 61 has a substantially rectangular main surface portion 61a, a side wall 61b surrounding the main surface portion 61a, and a concave portion 61c recessed from the main surface portion 61a by one step. A substantially cylindrical storage section side connection cylinder 66 is provided in the concave section 61c. A positioning protrusion 61d is provided on a side wall 61b of the outer case 61 (see FIG. 2). The positioning protrusion 61 d is inserted into the positioning groove 26 provided in the mounting portion 21 when the liquid medicine filling unit 5 is attached to the liquid medicine filling device 1.

  As shown in FIG. 3, the chemical solution storage part 62 is formed in a substantially cylindrical shape, and one surface is closed and the other surface is open. A filling port 62a and a liquid sending port 62b are provided at the closed end of the chemical solution storage unit 62. A chemical is injected from the filling port 62a, and air or a chemical is sent out from the liquid sending port 62b. When the liquid medicine filling unit 5 is mounted on the liquid medicine filling apparatus 1, the liquid sending port 62b is disposed above the filling port 62a in the vertical direction.

  The liquid sending tube 69 is connected to the liquid sending port 62b. The storage section side connection port 63 is connected to an end of the liquid transfer tube 69 opposite to the liquid transfer port 62b. The storage section side connection port 63 is arranged on the storage section side connection cylinder 66 in the outer case 61.

  Further, a pusher member 64 is slidably inserted into the cylindrical hole of the chemical solution storage unit 62. The pusher member 64 includes a gasket 64a that moves in close contact with the inner peripheral surface of the chemical solution storage unit 62 in a liquid-tight manner, a shaft portion 64b attached to the gasket 64a, and a nut piece 64c fixed to the shaft portion 64b. Have. The nut piece 64c is provided on the shaft portion 64b on the side opposite to the gasket 64a. When the chemical storage device 2 and the drive unit are combined together, the nut piece 64c is engaged with a screw shaft of a drive mechanism provided in the drive unit.

  As shown in FIG. 3, the nut piece 64c engages with the hook piece 38a of the filling amount adjusting mechanism 12 when the chemical liquid filling unit 5 is attached to the chemical liquid filling device 1.

[Filling adapter]
Next, the filling adapter 3 will be described.

  The filling adapter 3 includes a main body 71, a support portion 72, a first connection port 73, a second connection port 74, a liquid sending needle tube 75 and a ventilation needle tube 76 held by the main body 71, 77. Further, the filling adapter 3 has a protection mechanism 78 provided on the main body 71.

[Main unit]
The main body 71 is formed in a substantially rectangular parallelepiped shape. On one side of the main body 71 in the longitudinal direction, a support portion 72, a protection mechanism 78, a needle tube 75 for liquid feeding, and a needle tube 76 for ventilation are arranged. A first connection port 73 and a second connection port 74 are arranged on the other side of the main body 71 in the longitudinal direction. The first connection port 73 and the second connection port 74 are formed in a substantially columnar shape. The first connection port 73 is inserted into the storage section side connection cylinder 66 of the drug solution storage device 2 and connected to the storage section side connection port 63. Further, the second connection port 74 is inserted into the suction side connection hole 27 of the liquid medicine filling device 1 and connected to the suction side connection port 55.

  In addition, a communication path 84 (see FIG. 4) that allows the first connection port 73 and the second connection port 74 to communicate with each other is formed in the main body 71. The communication passage 84 is provided with a ventilation filter 77 (see FIGS. 4 and 5). The ventilation filter 77 has a mechanism that allows only gas such as air to pass and does not allow liquid to pass.

[Needle tube for sending liquid and needle tube for ventilation]
A needle point is provided at one end of the liquid supply needle tube 75 and one end of the ventilation needle tube 76, respectively. One end of the liquid sending needle tube 75 and one end of the ventilation needle tube 76 are pierced by a rubber stopper that seals the opening of the vial 4 and penetrate the rubber stopper. A needle tip is also provided at the other end of the liquid sending needle tube 75. The other end of the liquid sending needle tube 75 is pierced into the filling port 62a of the drug solution storage part 62 and penetrates the filling port 62a. The other end of the liquid supply needle tube 75 is bent in a substantially L shape.

  The liquid sending needle tube 75 and the ventilation needle tube 76 are held by the main body 71. One end sides of the liquid supply needle tube 75 and the ventilation needle tube 76 protrude from one surface of the main body 71. In addition, the other end side of the liquid sending needle tube 75 protrudes from the other surface, which is a surface opposite to one surface of the main body 71. That is, the liquid supply needle tube 75 is provided to penetrate the main body 71 in the up-down direction. The other end of the ventilation needle tube 76 protrudes from the other surface of the main body 71, or its end surface is located on the same plane as the other surface. The other end of the ventilation needle tube 76 does not have to protrude from the other surface of the main body 71, and for example, a ventilation hole communicating with the ventilation needle tube 76 may be provided in the main body 71.

  On one side of the main body 71 in the longitudinal direction, a substantially cylindrical support part 72 is provided. The opening of the support portion 72 is set to a size into which the mouth of the vial 4 can be inserted. One end sides of the liquid supply needle tube 75 and the ventilation needle tube 76 are arranged in the cylindrical hole of the support portion 72. In other words, the support portion 72 is formed in a cylindrical shape that covers the periphery of the liquid sending needle tube 75 and the ventilation needle tube 76, and is radially separated from the needle tip on one side of the liquid sending needle tube 75 and the ventilation needle tube 76. It is provided. Thereby, it is possible to prevent the user from accidentally puncturing the needle tips at one end of the liquid sending needle tube 75 and the ventilation needle tube 76.

  The protection mechanism 78 (see FIGS. 1 and 2) is provided in the main body 71 and is rotatably disposed near the other end of the liquid sending needle tube 75 in the main body 71. The protection mechanism 78 covers the other end side of the liquid sending needle tube 75 by rotating. Thereby, the needle point at the other end of the liquid sending needle tube 75 after the filling operation is completed can be covered, and the used filling adapter 3 can be in a safe state.

1-2. Next, an example of a chemical liquid filling method using the chemical liquid filling set 10 of the present embodiment will be described with reference to FIGS.
FIG. 4 is an explanatory diagram schematically showing a filling operation of a chemical solution. FIG. 5 is a front view of the liquid medicine filling set 10 showing an operation of filling the liquid medicine storage section 62 of the liquid medicine storage device 2 with the liquid medicine. 6 and 7 are explanatory diagrams showing the operation of the notification mechanism 100 during the filling operation.

  First, as shown in FIG. 2, the user stands the chemical liquid filling device 1 on a desk or table such that the opening on the upper surface 16 b side of the mounting portion 21 faces upward. In addition, the chemical liquid filling device 1 is provided with a pedestal portion 18 that extends on both sides of the first side surface portion 16d and the second side surface portion 16e below the housing 11. Thereby, the chemical | medical solution filling apparatus 1 can be stably stood on a desk or a base.

  Next, the operation unit 35 of the chemical liquid filling device 1 is operated to set a display piece (not shown) at a predetermined scale position. The setting of the filling amount adjusting mechanism 12 may be performed before placing the chemical liquid filling device 1 on a desk or a table, or may be performed after attaching the chemical liquid filling unit 5 to the chemical liquid filling device 1.

  Here, the filling adapter 3 is attached to the drug solution storage device 2 in advance. The other end of the liquid supply needle tube 75 in the filling adapter 3 penetrates the filling port 62 a of the drug solution storage unit 62. Further, the first connection port 73 is inserted into the storage section-side connection cylinder 66 of the drug solution storage device 2. Thus, the liquid supply port 62b, the liquid supply tube 69, and the storage unit side connection port 63 of the drug solution storage device 2 communicate with the first connection port 73 of the filling adapter 3.

  Next, as shown in FIGS. 1 and 3, the chemical filling unit 5 is attached to the chemical filling device 1. Specifically, the protrusion 61 d of the drug solution storage device 2 is inserted into the positioning groove 26 of the mounting portion 21, and the drug solution storage device 2 is mounted on the mounting portion 21. Further, the second connection port 74 of the filling adapter 3 is inserted into the suction side connection hole 27 of the liquid medicine filling device 1. Thereby, the second connection port 74 and the suction-side connection port 55 communicate with each other. Then, as shown in FIG. 4A, the internal space of the syringe 47 of the suction mechanism 13 and the internal space of the chemical solution storage unit 62 are communicated via the liquid supply port 62b, the liquid supply tube 69, the communication path 84, and the suction tube 46. You. Further, a suction passage 95 is configured by the liquid feeding tube 69, the communication passage 84, and the suction tube 46.

  The engagement piece 43 protruding from the mounting portion 21 is engaged with the side wall 61 b of the outer case 61 in the chemical solution storage device 2. Thereby, the drug solution storage device 2 can be stably mounted on the mounting portion 21.

  Further, the hook piece 38a of the filling amount adjusting mechanism 12 is engaged with the nut piece 64c of the drug solution storage device 2, and the insertion position of the pusher member 64 into the drug solution storage portion 62 is held at a predetermined position. Thereby, as shown in FIG. 3, the position of the pusher member 64 in the gasket 64a in the chemical solution storage unit 62 is maintained, and the capacity in the chemical solution storage unit 62 can be maintained at the set amount. Further, even after the chemical solution storage device 2 is mounted on the mounting portion 21, the position of the hook piece 38a that engages with the nut piece 64c can be changed by operating the operation portion 35, and the capacity of the chemical solution storage portion 62 can be reduced. Can be easily changed.

  Next, the vial 4 having the drug solution is attached to the support portion 72 of the filling adapter 3. As a result, one end of the liquid supply needle tube 75 and the ventilation needle tube 76 of the filling adapter 3 penetrates the rubber stopper of the vial 4, and the internal space of the liquid supply needle tube 75, the ventilation needle tube 76 and the vial bottle 4 is formed. Communicate. The other end of the liquid supply needle tube 75 penetrates the filling port 62 a of the chemical solution storage unit 62. Therefore, as shown in FIG. 4A, the internal space of the vial 4 and the internal space of the chemical solution storage unit 62 communicate with each other via the liquid supply needle tube 75.

  The vial 4 may be attached to the filling adapter 3 before attaching the chemical filling unit 5 to the chemical filling device 1.

  Next, as shown in FIG. 5, the user grips the housing 11, grips the lever member 48, and rotates the lever member 48. As shown in FIGS. 6A and 6B, when the pressure in the suction tube 46 and the syringe 47 is equal to the atmospheric pressure, the load applied to the lever member 48 is light. When the load applied to the lever member 48 is smaller than the urging force of the first urging spring 103 and the engaging force between the engaging portion 101b and the engaged portion 102b, the second member 102 moves to the reference position shown in FIG. 6A. From P, it moves to the other axial side of the syringe 47 together with the first member 101. Therefore, the suction side pusher 49 connected to the second member 102 via the connection pin 102a also moves, and the capacity in the syringe 47 increases.

  In addition, the syringe 47 is provided with a second check valve 52 that opens only when the gas is discharged from the syringe 47 to the outside, and closes when the gas is sucked into the syringe 47 from the outside. . Therefore, the pressure in the syringe 47 temporarily decreases. Then, since the pressure in the syringe 47 becomes a negative pressure, the suction mechanism 13 sucks air from the suction tube 46 side.

  Thereby, as shown in FIG. 4B, the air in the drug solution storage unit 62 is sucked into the syringe 47 via the suction passage 95. As a result, the inside of the chemical solution storage unit 62 becomes a negative pressure. Further, when the air of the drug solution storage unit 62 flows into the syringe 47, the pressure in the syringe 47 returns to the initial value, that is, the atmospheric pressure.

  Further, since the inside of the chemical solution storage unit 62 has a negative pressure, the chemical solution M1 is injected from the vial 4 into the chemical solution storage unit 62 through the liquid supply needle tube 75 and the filling port 62a. External air is sent into the vial 4 via a ventilation needle tube 76. In this way, the user can easily inject the drug solution M1 into the drug solution storage unit 62 by gripping the lever member 48.

  When the user stops the gripping operation of the lever member 48, the suction side pusher 49 is urged by the pressing spring 53 and inserted into the syringe 47. The suction tube 46 is provided with a first check valve 51 that shuts off air flowing from the syringe 47 to the suction-side connection port 55. Further, as described above, the syringe 47 opens only when the gas is discharged from the syringe 47 to the outside of the apparatus, and closes when the gas is sucked into the syringe 47 from the outside. A valve 52 is provided. Therefore, the air in the syringe 47 is discharged to the outside via the second check valve 52 instead of the suction tube 46 side. Further, the moving force of the suction side pusher 49 is transmitted to the lever member 48 via the notification mechanism 100, and the lever member 48 returns to the initial state shown in FIG.

  Then, the user repeats the gripping operation of the lever member 48. As a result, the air in the drug solution storage unit 62 is sucked by the suction mechanism 13 of the drug solution filling device 1 to have a negative pressure, and the drug solution M1 is injected into the drug solution storage unit 62 from the vial 4.

  When the inside of the chemical solution storage unit 62 is filled with the chemical solution M1, as shown in FIG. 4B, the chemical solution M1 is filled up to the liquid sending tube 69. Here, the suction passage 95 is provided with a ventilation filter 77 that allows only gas such as air to pass and does not allow liquid to pass. Then, the chemical solution M1 is filled up to the chemical solution storage part 62 and the ventilation filter 77 in the suction passage 95.

  When the chemical liquid M1 is filled up to the chemical liquid storage part 62 and the ventilation filter 77 in the suction passage 95 and the air is exhausted, the air cannot be sucked by the suction mechanism 13 and the pressure in the suction tube 46 and the syringe 47 becomes negative. In pressure. Therefore, the load applied to the lever member 48 increases, and the turning operation of the lever member 48 becomes hard.

  When the load applied to the lever member 48 is larger than the urging force of the first urging spring 103 and the engaging force between the engaging portion 101b and the engaged portion 102b, as shown in FIGS. 7A and 7B, the engaging portion 101b And the engaged portion 102b is released. Therefore, the second member 102 and the suction side pusher 49 do not move from the reference position P, and only the first member 101 moves to the other axial side of the syringe 47.

  Further, when the engagement between the engaging portion 101b and the engaged portion 102b is released and the engaging portion 101b gets over the engaged portion 102b, a click feeling and a click sound are generated. Thereby, the user can know that the chemical solution M1 has been filled in the chemical solution storage part 62 by a click feeling or a click sound generated when the lever member 48 is gripped. This makes it possible to easily determine the completion of the filling of the chemical solution storage unit 62.

  Then, when the user stops the gripping operation of the lever member 48, the first member 101 is urged by the first urging spring 103 and returns to the initial position shown in FIGS. 3 and 7A.

  In this example, an example has been described in which the user is notified of the completion of the filling of the medicinal solution M1 with a click feeling or a click sound generated when the engagement between the engaging portion 101b and the engaged portion 102b is released. It is not limited to this. For example, a detection unit that detects the release of the engagement between the engagement unit 101b and the engaged unit 102b is provided. When the detection unit detects the release of the engagement between the engagement unit 101b and the engaged unit 102b, The notification unit that notifies the user of the completion of the filling by sound, light, or the like may be operated.

  Further, the liquid sending port 62b from which the air is sucked in the chemical solution storage unit 62 is disposed vertically above the filling port 62a into which the chemical solution M1 is injected. Furthermore, by suctioning the air in the drug solution storage unit 62 with the suction mechanism 13 of the drug solution filling device 1, the air in the drug solution storage unit 62 can be exhausted from the liquid feed port 62b without leaving any excess. As a result, it is possible to omit the operation of operating the pusher member 64 provided on the chemical solution storage device 2 after the chemical solution filling operation to remove the air remaining from the chemical solution storage unit 62. Further, since there is no need to operate the pusher member 64, the capacity of the drug solution storage unit 62 does not change, so that an appropriate amount can be filled in the drug solution storage unit 62 and the amount of the drug solution M1 generated at the time of air release is reduced. Emissions can also be eliminated.

  Further, the filling operation can be performed in a state where the liquid feeding port 62b and the filling port 62a are arranged vertically above the gasket 64a of the pusher member 64 by the chemical liquid filling device 1.

  Next, the chemical filling unit 5 is removed from the chemical filling device 1. Specifically, the release button 42 is pressed. Thereby, the guide member 37 rotates around the swing pin (not shown). As a result, the engagement between the engagement piece 43 and the outer case 61 is released, and the engagement between the hook piece 38a and the nut piece 64c is released.

  Next, the chemical filling unit 5 is pulled out upward. Thereby, the second connection port 74 is pulled out from the suction side connection hole 27, and the drug solution storage device 2 is removed from the mounting portion 21. As a result, external air enters the syringe 47 from the suction side connection port 55 and the suction tube 46, and the pressure of the syringe 47 returns to the atmospheric pressure. Thus, the operation of filling the chemical solution storage unit 62 with the chemical solution is completed. The vial 4 may be removed from the filling adapter 3 before removing the chemical filling unit 5 from the chemical filling device 1.

<Modification>
Next, a modification of the notification mechanism will be described with reference to FIGS. 8 and 9.
FIG. 8 is an explanatory diagram showing a modification of the notification mechanism, and FIG. 9 is a block diagram showing a configuration of a control system in a modification of the notification mechanism.

  As shown in FIG. 8, the lever member 48 and the suction side pusher 49 are connected via a link member 50. The link member 50 is provided with a load detection unit 201 constituting a notification mechanism. The load detection unit 201 is, for example, a strain gauge that detects a strain of the link member 50. As described above, when the drug solution M1 is filled in the drug solution storage unit 62, the load applied to the lever member 48 increases. Then, the load applied to the link member 50 connecting the lever member 48 and the suction side pusher 49 also increases, and the link member 50 is slightly distorted. The load detecting unit 201 detects the strain generated in the link member 50.

  As illustrated in FIG. 9, the notification mechanism includes a load detection unit 201, a control unit 202 connected to the load detection unit 201, and a notification unit 203. The load detection unit 201 transmits the detected strain information of the link member 50 to the control unit 202.

  The control unit 202 calculates a load applied to the lever member 48 based on the strain information sent from the load detection unit 201. The notification unit 203 is connected to the control unit 202. The notification unit 203 has a configuration that can notify a user, such as a buzzer and a light emitting unit, for example. The control unit 202 determines whether or not the chemical solution storage unit 62 has been filled with the chemical solution M1 based on the calculated load information applied to the lever member 48. When the control unit 202 determines that the drug solution storage unit 62 has been filled with the drug solution M1, the control unit 202 activates the notification unit 203. Thereby, the user can be notified that the filling operation of the chemical solution M1 into the chemical solution storage unit 62 is completed.

  The present invention is not limited to the embodiment described above and shown in the drawings, and various modifications can be made without departing from the gist of the invention described in the claims. For example, the mounting portion may be configured to cover the entire exterior case 61 of the drug solution storage device 2. In this case, it is preferable to provide a viewing window through which the state of the drug solution storage unit 62 can be viewed in the mounting unit.

  DESCRIPTION OF SYMBOLS 1 ... Chemical liquid filling apparatus, 2 ... Chemical liquid storage device, 3 ... Filling adapter, 4 ... Vial bottle (chemical liquid container), 5 ... Chemical liquid filling unit, 10 ... Chemical liquid filling set, 11 ... Housing, 12 ... Filling amount adjustment mechanism, DESCRIPTION OF SYMBOLS 13 ... Suction mechanism, 16 ... 1st case, 17 ... 2nd case, 18 ... Base part, 21 ... Mounting part, 27 ... Suction side connection hole, 49 ... Suction side presser, 50 ... Link member, 51 ... 1st Check valve, 52: Second check valve, 55: Suction side connection port, 61: Outer case, 62: Chemical storage unit, 62a: Filling port, 62b: Liquid sending port, 73: First connection port, 74 ... Second connection port, 75: Needle tube for liquid feed, 76: Needle tube for ventilation, 77: Ventilation filter, 78: Protection mechanism, 95: Suction passage, 100: Notification mechanism, 101: First member, 101a: Connection pin, 1 1b ... engaging portion 102 ... second member, 102a ... connection pin, 102b ... engaged part, 201 ... load detection unit, 202 ... controller, 203 ... notification unit, M1 ... chemical

Claims (4)

A housing;
A mounting portion provided on the housing, and a mounting portion for mounting a drug solution storage portion having a filling port into which the drug solution is injected and a liquid sending port to send out the filled drug solution,
A suction-side connection port communicating with the liquid sending port;
A suction mechanism that suctions gas inside the chemical solution storage unit through the suction side connection port,
The suction mechanism,
A lever member rotatably provided on the housing,
A suction side pusher operated by the lever member,
A syringe into which the suction side pusher is slidably inserted,
A notification mechanism that notifies that the drug solution storage unit has been filled with the drug solution based on a load applied to the lever member,
When sucking the gas of the drug solution storage unit by the suction mechanism, a drug solution is filled into the drug solution storage unit from a drug solution container connected to the filling port,
The notification mechanism,
A first member attached to the lever member and having an engagement portion;
An engaging portion engaged with the engaging portion, the movably supporting the first member when the engagement between the engaging portion and the engaged portion is released, and pushing the suction side. A second member attached to the child,
The chemical filling device , wherein the engagement portion and the engaged portion are released from engagement when a predetermined load is applied to the lever member . The engaging portion and the engaged portion is filled with a drug solution according to claim 1, along the direction of movement of the first member is formed in a sawtooth shape having a plurality of irregularities. A housing,
A mounting portion provided on the housing, and a mounting portion for mounting a drug solution storage portion having a filling port into which the drug solution is injected and a liquid sending port to send out the filled drug solution,
A suction-side connection port communicating with the liquid sending port;
A suction mechanism that suctions gas inside the chemical solution storage unit through the suction side connection port,
The suction mechanism,
A lever member rotatably provided on the housing,
A suction side pusher operated by the lever member,
A syringe into which the suction side pusher is slidably inserted,
A notification mechanism that notifies that the drug solution storage unit has been filled with the drug solution based on a load applied to the lever member,
When sucking the gas of the drug solution storage unit by the suction mechanism, a drug solution is filled into the drug solution storage unit from a drug solution container connected to the filling port,
The lever member and the suction side pusher are connected via a link member,
The notification mechanism,
A load detection unit provided on the link member and detecting a strain of the link member,
An informing unit that informs that the drug solution has been filled in the drug solution storage unit,
A control unit that operates the notification unit based on the strain information of the link member detected by the load detection unit . The drug solution filling device according to any one of claims 1 to 3 , wherein a ventilation filter that allows only gas and does not allow the drug solution to pass is provided between the suction side connection port and the liquid sending port.

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