JP6621453B2 - Sex hormone concentration estimation device, sex hormone concentration estimation method, and program - Google Patents

Description

  The present invention relates to a sex hormone concentration estimation device, a sex hormone concentration estimation method, and a program.

  Conventionally, it is known to measure cortisol concentration from body fluid such as blood, urine, saliva, etc. of a subject using a specialized analyzer. For example, Non-Patent Document 1 describes that the cortisol concentration is measured by a body fluid by an RIA (Radio Immuno Assay) method and an EIA method (Enzyme Immuno Assay) method. In addition, liquid chromatography tandem mass spectrometry is also known as a method for measuring cortisol concentration from body fluids. Non-Patent Document 2 describes that there is a negative correlation between the amount of parasympathetic nerve activity of a subject under a high stress level and the cortisol concentration measured from saliva.

Hershel Raff, 1 other, "Circadian rhythm of salivarycortisol, plasma cortisol, and plasma ACTH in end-stage renal disease", Endocrine Connections, October 2012, 2: 23-31 Kozo Yoshino and three others, “Correlation between bedtime salivary cortisol concentration and autonomic nervous system activity balance in young men”, Stress Science Research 2011, 26, 48-52

  The ratio of sex hormone concentration to cortisol concentration is measured from the body fluid of the subject using an analyzer. The body fluid is, for example, blood, urine, saliva. For this reason, in order to measure the ratio of sex hormone concentration to cortisol concentration, it is unavoidable to collect a body fluid from a subject or to prepare an analyzer, which cannot be easily measured. It was.

  In addition, when the RIA method and the EIA method as described above are used, it may take several days or more to measure the cortisol concentration, and may not be accurately measured. Further, according to the liquid chromatography tandem mass spectrometry, the cortisol concentration is accurately measured, but it takes several days or more. In order to estimate the cortisol concentration based on the correlation with the heart rate, it is necessary to measure the heart rate after placing the subject in a specific state of high stress. In Non-Patent Document 3, it has not been confirmed that there is a correlation between the heart rate and the cortisol concentration in a state other than a high stress state or a time zone other than before going to bed, and this is a future problem. Therefore, there is a problem that it is difficult to quickly and easily grasp the cortisol concentration in any time zone and in a state where there is no high stress by any of the above-described methods.

  Thus, since it is difficult to measure the ratio of the sex hormone concentration to the cortisol concentration and the cortisol concentration quickly and easily, it is difficult to measure the sex hormone concentration quickly and easily.

  An object of the present invention made in view of such circumstances is to provide a sex hormone concentration estimation device, a sex hormone concentration estimation method, and a program capable of estimating a sex hormone concentration quickly and easily.

  In order to solve the above problems, a sex hormone concentration estimation apparatus according to the present invention is a sex hormone concentration estimation apparatus for estimating a sex hormone concentration of a subject, and is correlated with the autonomic nerve activity of the subject. A first calculation unit that calculates a rate of change of the activity index value in a first predetermined time interval, and a representative of the heart rate related index value related to the heart rate of the subject measured at each time in a second predetermined time interval A change calculated by the first calculation unit such that the second calculation unit for calculating the value and a predetermined rate of change of the autonomic nervous activity index value and a ratio of the sex hormone concentration to the cortisol concentration have a negative correlation The ratio of the sex hormone concentration to the cortisol concentration calculated from the rate, and the representative value of the predetermined heart rate-related index value and the cortisol concentration are positively correlated with each other by the second arithmetic unit. And cortisol concentration in the subject is calculated from the issued the representative value, characterized in that it comprises an estimation unit for estimating the hormone concentration based on.

Moreover, the sex hormone concentration estimation device according to the present invention is a sex hormone concentration estimation device for estimating the sex hormone concentration of a subject,
A first computing unit that calculates a rate of change in a first predetermined time interval of an autonomic nerve activity index value correlated with the subject's autonomic nerve activity;
A second calculation unit that calculates a representative value in a second predetermined time interval of a heartbeat-related index value related to the heartbeat of the subject measured at each time;
Based on the first relationship between the rate of change of the predetermined autonomic nervous activity index value and the ratio of the sex hormone concentration to the cortisol concentration, it is calculated from the rate of change calculated by the first calculation unit. Based on the ratio of the sex hormone concentration to the cortisol concentration and the second relationship between the representative value of the predetermined heart rate-related index value and the cortisol concentration, the representative value calculated by the second calculating unit is used. An estimation unit that estimates the sex hormone concentration based on the calculated cortisol concentration of the subject;
With
The first relationship is the estimation of the ratio of the sex hormone concentration to the cortisol concentration of the subject when the rate of change of the autonomic nerve activity index value during presentation from the autonomic nerve activity index value before presentation is the first value. The ratio of the sex hormone concentration to the cortisol concentration of the subject when the rate of change from the pre-presentation autonomic nerve activity index value to the second value larger than the first value is greater than the value The estimated value of becomes smaller,
The second relationship is a fourth value in which the representative value is greater than the third value than the estimated value of the cortisol concentration of the subject when the representative value of the heartbeat-related index value is a third value. In this case, the cortisol concentration of the subject is a large value.

  The sex hormone concentration estimation method according to the present invention is a sex hormone concentration estimation method for estimating the sex hormone concentration of a subject, and is a first autonomic nervous activity index value correlated with the subject's autonomic nervous activity. A step of calculating a rate of change in a predetermined time interval, a step of calculating a representative value in a second predetermined time interval of the heartbeat-related index value related to the heartbeat of the subject measured at each time, and The ratio of the sex hormone concentration to the cortisol concentration calculated from the change rate is determined in advance so that the change rate of the obtained autonomic nervous activity index value and the ratio of the sex hormone concentration to the cortisol concentration have a negative correlation. The sex hormone concentration based on the subject's cortisol concentration calculated from the representative value so that the representative value and the cortisol concentration have a positive correlation. Characterized in that it comprises the steps of: estimating a.

  The sex hormone concentration estimation method according to the present invention is a sex hormone concentration estimation method for estimating the sex hormone concentration of a subject, and is a first autonomic nervous activity index value correlated with the subject's autonomic nervous activity. A step of calculating a rate of change in a predetermined time interval, a step of calculating a representative value in a second predetermined time interval of the heartbeat-related index value related to the heartbeat of the subject measured at each time, and Cortisol concentration calculated from the change rate calculated by the first calculation unit based on the first relationship between the change rate of the obtained autonomic nervous activity index value and the ratio of the sex hormone concentration to the cortisol concentration Calculated by the second calculation unit based on the second relationship between the ratio of the sex hormone concentration to and the representative value of the predetermined heart rate-related index value and the cortisol concentration. Estimating the sex hormone concentration based on the subject's cortisol concentration calculated from the representative value, wherein the first relationship is before the presentation of the autonomic nervous activity index value being presented The pre-presentation autonomic nerve activity index of the presenting autonomic nerve activity index value rather than the estimated value of the ratio of the sex hormone concentration to the cortisol concentration of the subject when the rate of change from the autonomic nerve activity index value is the first value The estimated value of the ratio of the sex hormone concentration to the cortisol concentration of the subject when the rate of change from the value is a second value greater than the first value is a relationship, and the second relationship is the heart rate The cortisol concentration of the subject when the representative value is a fourth value larger than the third value is larger than the estimated value of the subject cortisol concentration when the representative value of the related index value is the third value. Characterized in that it is a relation of a value.

  The program according to the present invention causes a computer to function as the sex hormone concentration estimation apparatus.

  According to the present invention, the sex hormone concentration can be estimated quickly and easily.

It is a figure which shows an example of the finger plethysmogram measured by the sphygmograph before and during the output of the stimulation sound from the headphones. It is a figure which shows the ratio of the amplitude value at the time of presenting the stimulus at the time of normalizing the average value of the amplitude value of the pulse wave before presenting the stimulus. It is a figure which shows the correlation with the change rate of the amplitude value of a pulse wave, and sex hormone / testosterone concentration ratio. It is a figure which shows an example of the time change of the heart rate calculated from the electrocardiogram. It is a figure which shows the correlation with the representative value of the heart rate at rest, and cortisol concentration. It is a block diagram which shows the structural example of the sex hormone concentration estimation apparatus which concerns on one Embodiment of this invention. It is a flowchart which shows an example of the sex hormone concentration estimation method which concerns on one Embodiment of this invention. It is a flowchart which shows the detail of estimation of the sex hormone concentration shown in FIG.

  In describing the embodiment of the present invention, first, the correlation between the finger plethysmogram and the ratio of sex hormone concentration to cortisol concentration discovered by the inventors will be described.

  Hereinafter, the “ratio of sex hormone concentration to cortisol concentration” may be referred to as “sex hormone / cortisol concentration ratio”.

  In an experiment conducted by the inventors, a stimulus for changing autonomic nerve activity was presented to 20 subjects three times each, and the subject's autonomic nerve activity index was measured before and during the presentation. The value was measured. In this experiment, as shown in FIG. 1, stimulation was presented to the subject wearing the headphones by outputting stimulation sound from the headphones. The stimulus sound is, for example, a sound generated when a nail or the like scratches the blackboard. In this experiment, the autonomic nerve activity index value is the amplitude value of the fingertip pulse wave indicating the volume of the peripheral blood vessel. The inventors measured fingertip pulse waves by attaching a pulse wave meter to the subject's finger.

  In this experiment, saliva was collected from each of the 20 subjects, and the sex hormone / cortisol concentration ratio in the saliva was measured. In the experiment, the test subject was a male and testosterone was used as a sex hormone.

  FIG. 1 is a diagram illustrating an example of a pulse wave of a subject measured by a pulse wave meter before and during output of stimulation sound from headphones. As shown in FIG. 1, it was found that in many subjects, the amplitude value of the pulse wave during the presentation of the stimulus tends to be smaller than before the presentation of the stimulus.

FIG. 2 is a diagram showing the ratio of the amplitude value during the presentation of the stimulus to the average value of the amplitude value of the pulse wave before the presentation of the stimulus. The inventors measured the pulse wave during the stimulus presentation by integrating the value obtained by subtracting the average value of the amplitude of the pulse wave before the stimulus presentation from the amplitude value of the pulse wave during the stimulus presentation. The value divided by the time was calculated as a value x (hereinafter referred to as “change rate x”) corresponding to the degree of decrease in the amplitude value. Note that the change rate x of the amplitude value is expressed by Expression (1). In Expression (1), T is the time (for example, 60 seconds) during which the pulse wave is measured during the presentation of the stimulus. F (t) is the amplitude value of the pulse wave at time t during presentation of the stimulus. F _ave is an average value of a predetermined time (for example, 10 seconds) of the amplitude value before the presentation of the stimulus.

  FIG. 3 is a graph showing the relationship between the change rate of the amplitude value of the pulse wave and the ratio of the testosterone concentration to the cortisol concentration. Testosterone is an example of a sex hormone. Hereinafter, the “ratio of testosterone concentration to cortisol concentration” may be referred to as “testosterone / cortisol concentration ratio”. The vertical axis represents the testosterone / cortisol concentration ratio measured from the saliva of the subject. The horizontal axis represents the rate of change of the amplitude value of the pulse wave. It can be seen from FIG. 3 that the testosterone / cortisol concentration ratio tends to decrease as the change rate of the amplitude value of the pulse wave increases. In this way, the inventors have a negative correlation between the autonomic nerve activity index value taking the amplitude value of the pulse wave as an example and the sex hormone / cortisol concentration ratio taking the testosterone / cortisol concentration ratio as an example. I found out. Although the experiment was conducted on males, the correlation between the finger plethysmogram and the ratio of sex hormone concentration to cortisol concentration is expected to hold not only for male hormones but also for female hormones (estrogens). Therefore, it is generalized here as “correlation with the ratio of sex hormone concentration to cortisol concentration”.

  The correlation function between the autonomic nerve activity index value and the sex hormone / cortisol concentration ratio can be derived from the experimental results. Although the correlation function varies depending on the environment and conditions of the experiment, an example is shown in Equation (2). In the formula (2), T / COR is a testosterone / cortisol concentration ratio. x is the rate of change of the amplitude value calculated by the above equation (1). In the present invention, the testosterone / cortisol concentration ratio is calculated using the negative correlation or correlation function thus derived.

  T / COUNT = −0.00115 × x + 0.0864 Formula (2)

  Next, the correlation between heart rate and cortisol concentration will be described.

  In experiments conducted by the inventors, heart rate related index values related to the heart rate of 20 subjects in a resting state were measured. In this experiment, the heart rate related index value is the heart rate. In addition, the inventors calculated a representative value of the heart rate related index value, that is, a representative value of the heart rate. The representative value is, for example, a value obtained by statistically calculating the heart rate measured within a predetermined time such as an average value or an intermediate value. A known electrocardiograph was used for measuring the heart rate. Here, “rest state” is used to mean “not performing a task”. In other words, it does not mean “absolute rest” in which the person does not lie down, but means that the task (task) has not been performed, in other words, “normal state”.

  The electrocardiograph measures the voltage between electrodes attached to the subject. The electrocardiograph calculates the heart rate based on the RR interval, which is the interval between one R wave and the R wave adjacent to the one R wave. Thereby, the electrocardiograph can measure the time change of the heart rate as shown in FIG.

  Moreover, in this experiment, when the heart rate related index value was measured as described above, saliva was collected from each of 20 subjects, and the cortisol concentration in the saliva was measured.

  FIG. 5 is a diagram showing the relationship between cortisol concentration and a representative value of heart rate. The vertical axis represents the cortisol concentration measured from the saliva of the subject. The horizontal axis is a representative value of heart rate. The representative value here is the average value of the heart rate in a predetermined time interval. As shown in FIG. 5, it can be seen that the higher the representative value of the heart rate, the higher the cortisol concentration. Thus, the inventors have found that there is a positive correlation between the cortisol concentration and the representative value of the heart rate. In this experiment, unlike Non-Patent Document 3, the measurement is performed not in the time zone before bedtime but in the daytime. Also, the subject is not in a high stress state. That is, a positive correlation between the cortisol concentration and the heart rate-related index value for a subject in an arbitrary state (a state that is not a high stress state) in the daytime period, which has not been clarified in Non-Patent Document 3. It was observed.

  The correlation function between the heart rate related index value and the cortisol concentration can be derived from the experimental results. Although the correlation function varies depending on the environment and conditions of the experiment, an example is shown in Equation (3). In the formula (3), CORT is the cortisol concentration. HR is a representative value of heart rate. In the present invention, the cortisol concentration is calculated using the positive correlation or correlation function thus derived.

  CORT = 28.9 × HR-1035 Formula (3)

  Hereinafter, an embodiment of the present invention will be described in detail with reference to the drawings. FIG. 6 is a diagram illustrating a configuration example of the sex hormone concentration estimation apparatus 1 according to the embodiment. As shown in FIG. 6, the sex hormone concentration estimation apparatus 1 includes an input unit 11, an autonomic nervous activity index value storage unit 12, a first calculation unit 13, a heart rate related index value storage unit 14, and a second calculation unit. 15, an estimation unit 16, and an output unit 17. A subject whose sex hormone is estimated by the sex hormone concentration estimation device 1 is presented with a stimulus by the stimulus presentation device 4. The sex hormone concentration estimation apparatus 1 receives information output from the first measurement apparatus 51 and the second measurement apparatus 52. The sex hormone concentration estimation device 1 outputs information to the presentation device 6.

  The stimulus presentation device 4 presents a stimulus for changing the autonomic nerve activity to the subject. The stimulus is a sound, an image, light, or the like that fluctuates a human emotional value. The stimulus may be, for example, a sound generated when a nail or the like scratches the blackboard, or a sound created by performing signal processing on the sound. Stimulation is not limited to sounds generated when nails or the like scratches the blackboard, but sounds that fluctuate human emotional values, such as sounds that make people feel uncomfortable, sounds that make them feel uneasy, sounds that make people feel comfortable, etc. Any sound that changes the emotions is acceptable. When the stimulus is an image, an image / video that gives an unpleasant impression, an image / video that makes you feel anxious or feared, an image / video that makes you feel comfortable, and the like may be used. When the stimulus is light, a stimulus that gives a sense of security or anxiety to the person may be used depending on the color of the light, the presentation interval of the stimulus or the like. The stimulus presentation device 4 presents a stimulus sound for a predetermined time (for example, 1 minute or more). The predetermined time may be at least as long as it can detect a change in a biological reaction (biological signal) accompanying a change in the emotional value of the person presented with the stimulus.

  The first measuring device 51 measures an autonomic nerve activity index value that is an index value indicating the activity of the autonomic nerve activity of the subject within the first predetermined time interval. Specifically, the first measuring device 51 measures the subject's autonomic nerve activity index value as the pre-presenting autonomic nerve activity index value before presenting the stimulus to the subject, and is presenting the stimulus to the subject. Then, the autonomic nerve activity index value of the subject is measured as the autonomic nerve activity index value during presentation. Further, the first measuring device 51 outputs the measured pre-presentation autonomic nerve activity index value and the presenting autonomic nerve activity index value to the sex hormone concentration estimation device 1. The autonomic nerve activity index value is, for example, an amplitude value of a finger plethysmogram indicating the volume of a peripheral blood vessel, blood pressure, pupil diameter, or the like. In the present embodiment, an example in which the autonomic nerve activity index value is the amplitude value of the finger plethysmogram will be described below.

  The 1st measuring device 51 can be comprised by the well-known pulse wave meter which measures the amplitude value of a finger tip pulse wave, for example. Specifically, the first measurement device 51 measures the pre-presentation finger plethysmogram as an example of the pre-presentation autonomic nerve activity index value at a predetermined time before the stimulus presentation device 4 presents the stimulus to the subject, The stimulus presenting device 4 measures the presenting middle plethysmogram as an example of the presenting autonomic nerve activity index value at a predetermined time during the presentation of the stimulus to the subject. The first measuring device 51 outputs the measured pre-presentation finger plethysmogram and the presented middle finger plethysmogram to the sex hormone concentration estimation device 1.

  The second measuring device 52 measures the heart rate related index value for each time of the subject who is in a resting state for the second predetermined time interval, and outputs it to the sex hormone concentration estimating device 1. The heart rate related index value is an index value related to the heart rate. The predetermined time is a time (for example, 60 seconds) in which the representative value of the heartbeat-related index value calculated by the second calculation unit 15 is considered to effectively indicate the state of the subject. The representative value is a value obtained by statistically calculating a second predetermined time interval such as an average value or an intermediate value, and a measured heartbeat-related index value. In the present embodiment, an example in which the heart rate related index value is a heart rate will be described. In this case, the second measuring device 52 measures the heart rate and sequentially outputs the measured heart rate to the sex hormone concentration estimating device 1.

  Each structure with which the sex hormone concentration estimation apparatus 1 is provided is demonstrated in detail.

  The input unit 11 inputs the pre-presenting autonomic nerve activity index value and the presenting autonomic nerve activity index value output from the first measuring device 51. In the present embodiment, the input unit 11 inputs the pre-presentation finger plethysmogram and the presented middle finger plethysmogram output from the sex hormone concentration estimation apparatus 1. In addition, the input unit 11 inputs a heartbeat-related index value for each time that is measured by the second measuring device 52 for a second predetermined time interval and sequentially output. Specifically, the input unit 11 inputs time-series data of heart rate related index values. More specifically, the input unit 11 inputs time-series data of heart rate.

  The autonomic nerve activity index value storage unit 12 may include an arbitrary storage device such as a semiconductor storage device and a magnetic storage device, or may include a plurality of types of storage devices. The autonomic nerve activity index value storage unit 12 stores the pre-presentation autonomic nerve activity index value measured by the first measurement device 51 before the stimulus presentation device 4 presents the stimulus to the subject. In this embodiment, the autonomic nerve activity index value storage unit 12 stores the pre-presentation finger plethysmogram as the pre-presentation autonomic nerve activity index value.

  The first computing unit 13 is input by the input unit 11 and is an autonomic nerve activity index value before presentation that is an autonomic nerve activity index value before the stimulus is presented to the subject in the first predetermined time interval, and the stimulus The presenting autonomic nerve activity index value, which is the autonomic nerve activity index value of the subject during the presentation, is acquired. And the 1st calculating part 13 calculates the change rate from the autonomic nerve activity index value before presentation of the autonomic nerve activity index value during presentation. The rate of change can be, for example, the average value of the differences from the average value of the pre-presenting autonomic nerve activity index value of the presenting autonomic nerve activity index value. That is, the rate of change was calculated by integrating the difference from the average value of the autonomic nerve activity index value before presentation with the average value of the autonomic nerve activity index value before presentation and dividing by the time during which the autonomic nerve activity index value being presented was measured. Can be a value.

  In the present embodiment, as described above, the pre-presentation autonomic nerve activity index value is the amplitude value of the pre-presentation finger plethysmogram before the presentation of the stimulus to the subject, that is, a predetermined time before the stimulus presentation. It is time series data which consists of the amplitude value of the finger plethysmogram for every time in a section. In addition, the presenting autonomic nerve activity index value is the amplitude value of the subject's presenting middle finger plethysmogram during presentation of the stimulus to the subject, that is, the finger plethysmogram at each time in a predetermined time interval during the stimulus presentation It is time series data consisting of amplitude values. Therefore, the first calculation unit 13 acquires time-series data of the amplitude value of the pre-presenting finger plethysmogram and time-series data of the amplitude value of the presented middle finger plethysmogram from the first measuring device 51. And the 1st calculating part 13 calculates the change rate of an amplitude value based on the time series data of the amplitude value of the finger plethysmogram before presentation, and the time series data of the amplitude value of the middle finger plethysmogram presenting. For example, the first calculation unit 13 calculates the average value of the amplitude values of the pre-presentation finger plethysmogram, that is, the average value of the amplitude values from the time-series data of the pre-presentation finger plethysmogram. Then, the first calculation unit 13 calculates an integrated value of the difference between each amplitude value in the time-series data of the presented middle finger plethysmogram and the average value of the amplitude of the pre-presented finger plethysmogram. The value divided by the presented time is calculated as the change rate of the amplitude value.

  The heartbeat-related index value storage unit 14 may include an arbitrary storage device such as a semiconductor storage device and a magnetic storage device, or may include a plurality of types of storage devices. The heartbeat-related index value storage unit 14 stores time-series data of heartbeat-related index values measured by the second measuring device 52 for a second predetermined time interval and input by the input unit 11. Specifically, the heart rate related index value storage unit 14 stores the heart rate related index value continuously measured in the second predetermined time interval and the time when the heart rate related index value is measured in association with each other. The time may be an elapsed time from the start time.

  The second calculation unit 15 calculates a representative value of the heart rate related index value based on the time series data of the heart rate related index value stored in the heart rate related index value storage unit 14.

  The estimator 16 determines the sex hormone / cortisol concentration based on the rate of change calculated by the first calculator 13 so that the rate of change and the sex hormone / cortisol concentration ratio have a negative correlation (first relationship). Estimate the ratio. Specifically, when the rate of change is calculated by the first calculating unit 13, the estimating unit 16 has a negative correlation with the estimated result of the sex hormone / cortisol concentration ratio with respect to the rate of change, for example, Sex hormone / cortisol concentration level indicates that the higher the rate of change, the smaller the estimated result of the sex hormone / cortisol concentration ratio, or the smaller rate of change indicates the greater the estimated result of the sex hormone / cortisol concentration ratio. Estimate the ratio. Alternatively, the estimation unit 16 determines the sex hormone / cortisol concentration ratio when the change rate is a second value larger than the first value than the estimation result of the sex hormone / cortisol concentration ratio when the change rate is the first value. Estimate the sex hormone / cortisol concentration ratio so that the estimated result of is smaller. For example, the sex hormone / cortisol concentration ratio is estimated using the negative correlation function expressed by the above-described equation (2).

  In addition, the estimation unit 16 estimates the cortisol concentration so that the representative value of the heartbeat-related index value and the cortisol concentration have a positive correlation (second relationship). Specifically, when the representative value is calculated by the second calculator 15, the estimating unit 16 is configured so that the estimated value of the cortisol concentration is positively correlated with the representative value, that is, the representative value is large. The cortisol concentration is estimated so as to indicate that the estimated value of the cortisol concentration is large, or so that the estimated value of the cortisol concentration is small as the representative value is small. Alternatively, the estimating unit 16 determines that the estimated value of the cortisol concentration when the representative value is the fourth value larger than the third value is larger than the estimated value of the cortisol concentration when the representative value is the third value. As such, cortisol concentration is estimated. For example, the estimation unit 16 estimates the cortisol concentration based on a positive correlation function related to a representative value of a predetermined heart rate related index value. An example of the positive correlation function is a positive correlation function represented by the above-described equation (3).

  Furthermore, the estimation unit 16 estimates the sex hormone concentration based on the sex hormone / cortisol concentration ratio and the cortisol concentration estimated as described above. Specifically, a value obtained by multiplying the cortisol concentration by the sex hormone / cortisol concentration ratio is estimated as the sex hormone concentration.

  The output unit 17 outputs the sex hormone concentration estimated by the estimation unit 16 to the presentation device 6.

  The presentation device 6 presents the sex hormone concentration estimated by the estimation unit 16 and output by the output unit 17. Specifically, the presentation device 6 may display the sex hormone concentration on a display. Moreover, the presentation apparatus 6 may output the sound which shows a sex hormone density | concentration with a speaker.

  Next, a sex hormone concentration estimation method by the sex hormone concentration estimation apparatus 1 will be described with reference to FIG. FIG. 7 is a flowchart showing an example of a sex hormone concentration estimation method.

  First, the input unit 11 inputs the pre-presentation finger plethysmogram of the subject measured by the first measurement device 51 when the stimulus presentation device 4 is not presenting the stimulus to the subject (step S11).

  Next, the autonomic nervous activity index value storage unit 12 stores the pre-presentation finger plethysmogram input by the input unit 11 (step S12).

  Next, the stimulus presentation device 4 presents the stimulus to the subject for a predetermined time interval (step S13).

  While the stimulus presenting device 4 is presenting the stimulus to the subject, the input unit 11 inputs the subject's presented middle finger plethysmogram measured by the first measuring device 51 (step S14).

  Next, the first calculation unit 13 decreases the amplitude value of the finger plethysmogram based on the pre-presentation finger plethysmogram stored in step S12 and the presented middle finger plethysmogram measured in step S14. Is calculated (step S15).

  Next, the input unit 11 inputs a heartbeat-related index value for each measured time at the second predetermined time interval by the second measuring device 52 (step S16). Note that the second predetermined time interval is independent of the predetermined time interval in step S13.

  Next, the heart rate related index value storage unit 14 stores the time series data of the heart rate related index value for each time input by the input unit 11 (step S17).

  Next, the second calculation unit 15 calculates a representative value of the heart rate related index value in the second predetermined time interval from the heart rate related index value for each time stored in the heart rate related index value storage unit 14 (step S18). An example of the representative value is an average value of the heartbeat-related index values in the second predetermined time interval, but is not limited to this, and any value that represents the heartbeat-related index value in the second predetermined time interval may be used. Good.

  Next, the sex hormone concentration is estimated by the estimation unit 16 based on the degree of amplitude decrease and the representative value of the heart rate related index value (step S19).

  Here, the details of the method by which the estimation unit 16 estimates the sex hormone concentration will be described in detail with reference to FIG.

  First, the estimation unit 16 estimates the sex hormone / cortisol concentration ratio from the degree of decrease in the amplitude of the finger plethysmogram calculated in step S15 (step S191). Specifically, the sex hormone / cortisol concentration ratio is estimated so as to have a negative correlation with the degree of decrease in the amplitude of the fingertip pulse wave calculated in step S15.

  Next, the cortisol concentration is estimated by the estimation unit 16 so as to have a positive correlation with the representative value based on the representative value calculated in step S18 (step S192). Specifically, the cortisol concentration is estimated so as to have a positive correlation with the representative value calculated in step S18. For example, when the cortisol concentration estimated by the estimation unit 24 when the representative value is the first value is the first cortisol concentration, the estimation unit estimates when the representative value is a second value larger than the first value. The estimation process of the estimation unit 24 is performed so that the cortisol concentration becomes a second value larger than the first cortisol concentration.

  Next, the estimation unit 16 estimates a value obtained by multiplying the sex hormone / cortisol concentration ratio estimated in step S191 by the cortisol concentration estimated in step S192 as a sex hormone concentration (step S193).

  Returning to FIG. 7, the output unit 17 outputs the sex hormone concentration estimated in step S19 to the presentation device 6 (step S20).

  Note that some or all of the processing from step S11 to step S15 and the processing from step S16 to step S18 may be performed simultaneously in parallel. The process from step S11 to step S15 may be performed before the process from step S16 to step S18.

  In addition, a computer can be suitably used to function as the sex hormone concentration estimation apparatus 1 described above, and such a computer can store a program describing processing contents for realizing each function of the sex hormone concentration estimation apparatus 1. It can be realized by storing the program in a database of the computer, and reading and executing the program by the CPU of the computer.

  The program may be recorded on a computer readable medium. If a computer-readable medium is used, it can be installed on a computer. Here, the computer-readable medium on which the program is recorded may be a non-transitory recording medium. The non-transitory recording medium is not particularly limited, but may be a recording medium such as a CD-ROM or a DVD-ROM.

  As described above, according to the first embodiment, the sex hormone concentration estimation apparatus 1 uses the autonomic nerve activity index value correlated with the subject's autonomic nerve activity and the heart rate related index value related to the heart rate. Estimate sex hormone concentration based on. Therefore, the sex hormone concentration estimation apparatus 1 can quickly estimate the sex hormone concentration as compared with the case where the sex hormone concentration is measured using a body fluid as in the past. In addition, since the autonomic nerve activity index value and the heart rate related index value are non-invasively measured, the sex hormone concentration estimation apparatus 1 can easily measure the sex hormone concentration.

  In the above-described embodiment, the sex hormone concentration estimation apparatus 1 may include the stimulus presentation device 4 as a stimulus presentation unit. In this case, the stimulus presentation unit presents the stimulus to the subject. Moreover, the sex hormone concentration estimation apparatus 1 may include the first measurement device 51 as a first measurement unit. In this case, the first measurement unit measures the autonomic nervous activity index value of the subject. Moreover, the sex hormone concentration estimation apparatus 1 may include the second measurement device 52 as a second measurement unit. In this case, the second measurement unit measures the heart rate related index value of the subject.

  Moreover, in the above-mentioned embodiment, the sex hormone concentration estimation apparatus 1 may be provided with the presentation apparatus 6 as a presentation part. In this case, the presentation unit presents the testosterone concentration.

  Although the above embodiment has been described as a representative example, it will be apparent to those skilled in the art that many changes and substitutions can be made within the spirit and scope of the invention. Therefore, the present invention should not be construed as being limited by the above-described embodiments, and various modifications and changes can be made without departing from the scope of the claims.

1, 2, 3 Sex hormone concentration estimation device 4 Stimulus presentation device 6 Presentation device 11 Input unit 12 Index value storage unit 13 First calculation unit 14 Heart rate related index value storage unit 15 Second calculation unit 16 Estimation unit 17 Output unit 18 Hormone concentration storage unit 19 Determination unit 20 Reduction rate storage unit 51 First measurement device 52 Second measurement device 100 Sex hormone concentration estimation unit

Claims (5)

A sex hormone concentration estimation device for estimating a sex hormone concentration of a subject,
A first computing unit that calculates a rate of change in a first predetermined time interval of an autonomic nerve activity index value correlated with the subject's autonomic nerve activity;
A second calculation unit that calculates a representative value in a second predetermined time interval of a heartbeat-related index value related to the heartbeat of the subject measured at each time;
Ratio of sex hormone concentration to cortisol concentration calculated from the rate of change calculated by the first calculation unit so that the rate of change of autonomic nerve activity index value and the ratio of sex hormone concentration to cortisol concentration have a negative correlation And the cortisol concentration of the subject calculated from the representative value calculated by the second calculation unit so that the representative value of the heart rate-related index value and the cortisol concentration have a positive correlation. An estimation unit for estimating the hormone concentration;
A sex hormone concentration estimation apparatus comprising: A sex hormone concentration estimation device for estimating a sex hormone concentration of a subject,
A first computing unit that calculates a rate of change in a first predetermined time interval of an autonomic nerve activity index value correlated with the subject's autonomic nerve activity;
A second calculation unit that calculates a representative value in a second predetermined time interval of a heartbeat-related index value related to the heartbeat of the subject measured at each time;
Based on the first relationship between the rate of change of the predetermined autonomic nervous activity index value and the ratio of the sex hormone concentration to the cortisol concentration, it is calculated from the rate of change calculated by the first calculation unit. Based on the ratio of the sex hormone concentration to the cortisol concentration and the second relationship between the representative value of the predetermined heart rate-related index value and the cortisol concentration, the representative value calculated by the second calculating unit is used. An estimation unit that estimates the sex hormone concentration based on the calculated cortisol concentration of the subject;
With
The first relationship is the estimation of the ratio of the sex hormone concentration to the cortisol concentration of the subject when the rate of change of the autonomic nerve activity index value during presentation from the autonomic nerve activity index value before presentation is the first value. The ratio of the sex hormone concentration to the cortisol concentration of the subject when the rate of change from the pre-presentation autonomic nerve activity index value to the second value larger than the first value is greater than the value The estimated value of becomes smaller,
The second relationship is a fourth value in which the representative value is greater than the third value than the estimated value of the cortisol concentration of the subject when the representative value of the heartbeat-related index value is a third value. In this case, the sex hormone concentration estimating apparatus is characterized in that the cortisol concentration of the subject is a large value. A sex hormone concentration estimation method for estimating the sex hormone concentration of a subject,
Calculating a rate of change in a first predetermined time interval of an autonomic nerve activity index value correlated with the subject's autonomic nerve activity;
Calculating a representative value in a second predetermined time interval of a heartbeat-related index value related to the heartbeat of the subject measured at each time;
The ratio of the sex hormone concentration to the cortisol concentration calculated from the change rate so that the predetermined change rate of the autonomic nerve activity index value and the ratio of the sex hormone concentration to the cortisol concentration have a negative correlation, and the representative value Estimating the sex hormone concentration based on the subject's cortisol concentration calculated from the representative value so that the cortisol concentration and the cortisol concentration have a positive correlation;
A method for estimating a sex hormone concentration, comprising: A sex hormone concentration estimation method for estimating the sex hormone concentration of a subject,
Calculating a rate of change in a first predetermined time interval of an autonomic nerve activity index value correlated with the subject's autonomic nerve activity;
Calculating a representative value in a second predetermined time interval of a heartbeat-related index value related to the heartbeat of the subject measured at each time;
Based on the first relationship between the rate of change of the predetermined autonomic nervous activity index value and the ratio of the sex hormone concentration to the cortisol concentration, it is calculated from the rate of change calculated by the first calculation unit. Based on the ratio of the sex hormone concentration to the cortisol concentration and the second relationship between the representative value of the predetermined heart rate-related index value and the cortisol concentration, the representative value calculated by the second calculating unit is used. Estimating the sex hormone concentration based on the calculated cortisol concentration of the subject;
Including
The first relationship is the estimation of the ratio of the sex hormone concentration to the cortisol concentration of the subject when the rate of change of the autonomic nerve activity index value during presentation from the autonomic nerve activity index value before presentation is the first value. The ratio of the sex hormone concentration to the cortisol concentration of the subject when the rate of change from the pre-presenting autonomic nerve activity index value to the second value larger than the first value is greater than the value The estimated value of becomes smaller,
The second relationship is a fourth value in which the representative value is greater than the third value than the estimated value of the cortisol concentration of the subject when the representative value of the heartbeat-related index value is a third value. In this case, the sex hormone concentration estimation method is characterized in that the cortisol concentration of the subject is a large value.   A program for causing a computer to function as the sex hormone concentration estimating apparatus according to claim 1.

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