JP6409618B2 - Dentifrice composition - Google Patents

Description

  The present invention relates to a dentifrice composition containing a polyvalent metal compound that has an improved astringent feeling-imparting effect, gives a continuous astringent feeling, and suppresses dripping from the mouth of the preparation and has an excellent feeling of use.

In recent years, with the improvement of periodontal disease prevention awareness, there is an increasing need for oral care products in the periodontal disease care category. In particular, since bleeding from gums is mixed in the discharge after brushing and easily recognized visually, an oral care product having a hemostatic effect is required.
As an effective means for preventing or improving such bleeding, it is said that tightening of the oral cavity, particularly gums, is useful. As means for tightening gums, polyvalent metal compounds such as ferric sulfate and zinc chloride and natural astringents such as tannins are known as effective means (Patent Document 1: Japanese Patent No. 4230536), Among them, especially polyvalent metal compounds have high astringency, and are therefore blended in oral compositions and marketed.

  However, among the usability of the dentifrice composition, the dripping of the preparation from the mouth not only reduces the effect of the dentifrice composition but also is easily recognized as an unpleasant feeling of use, but the polyvalent metal The dentifrice composition containing the compound has a problem that liquid dripping occurs from the mouth during brushing and the feeling of use is inferior.

  As a method of enhancing the astringent effect in the oral cavity by the composition for oral cavity, a high astringent effect is exhibited by blending an aluminum compound typified by alum such as aluminum potassium sulfate, which is a polyvalent metal compound, and sodium chloride. A method has been proposed in which the metallic taste is not felt while being sustained (Patent Document 2: International Publication No. 2009/034919), but there is no mention of dripping from the mouth during use.

  On the other hand, polyethylene glycol is generally used as a moisturizer or thickener in the oral cavity field, but there are few examples of blending highly polymerized polyethylene glycol having a molecular weight of 100,000 or more in the preparation, and foaming liquid dentifrice. Examples used for improving performance (Patent Document 3: JP 2006-506359 A) and examples used for dentifrices that have an excellent effect of promoting remineralization of teeth (Patent Document 4: JP 2013-112613 A) ), An example (Patent Document 5: International Publication No. WO 2010/073975) is disclosed in which foaming property and persistence of foaming are improved by blending highly polymerized polyethylene glycol, alkyl sulfate and thickening silica. ing.

Japanese Patent No. 4230536 International Publication No. 2009/034919 JP 2006-506359 A JP 2013-112613 A International Publication No. 2010/073975

  Therefore, in the dentifrice composition, it has been desired to develop a technique for suppressing the dripping from the mouth of the preparation due to the polyvalent metal compound and applying it to the astringent feeling.

  The present invention has been made in view of the above circumstances, and a polyvalent metal compound having an excellent feeling of use with improved astringency imparting effect, giving a sustained astringent feeling, and suppressing dripping from the mouth of the preparation. It aims at providing the dentifrice composition containing.

  As a result of intensive studies to achieve the above object, the present inventor (A) 0.2 to 3% by mass of one or more aluminum compounds selected from aluminum potassium sulfate, aluminum ammonium sulfate and aluminum sulfate, (B) The viscosity of a 5 W / V% aqueous solution at 25 ° C. measured with a Brookfield viscometer is 10 mPa · s or more, and the viscosity of a 2 W / V% aqueous solution at 25 ° C. measured with the viscometer is 800 mPa · s. By blending 0.05 to 0.5 mass% of the following highly polymerized polyethylene glycol, the effect of imparting astringency is improved, giving a continuous astringency, and dripping from the mouth of the preparation The present inventors have found that a dentifrice composition containing a polyvalent metal compound that is suppressed and has an excellent feeling in use can be obtained, and has led to the present invention.

In other words, blending an astringent component into a dentifrice composition is effective as a means of preventing and improving periodontal diseases, but in a dentifrice composition blended with a polyvalent metal compound effective as an astringent component, Although it was difficult to improve the feeling of use focusing on the improvement of dripping from the mouth with the prior art, in the present invention, combining the components (A) and (B) unexpectedly only improves the effect of imparting a feeling of convergence. In addition, dripping from the mouth of the preparation can be suppressed and the feeling of use can be improved.
In this case, among the polyvalent metal compounds, particularly when an aluminum compound such as potassium aluminum sulfate (potash alum), which is a typical astringent component, is blended into the dentifrice composition, the foaming component and the like are salted out with the polyvalent metal, In the present invention, the component (A) is used in spite of the problem that foam disappears and dripping occurs, resulting in a problem that the usability is reduced. Combining (B) with an appropriate amount enhances the astringent feeling imparting effect, gives a convergent feeling that persists even after the elapse of 5 minutes after use, and blends an alkyl sulfate such as sodium lauryl sulfate as a foaming component. Even when brushing, it is possible to prevent the preparation from dripping from the mouth during brushing and to give an excellent feeling of use.
In addition, in patent document 2, a metal taste is suppressed by mix | blending sodium chloride with the dentifrice composition containing aluminum compounds, such as an aluminum potassium sulfate, and it has a favorable usability | use_condition, and examination about dripping of a formulation is considered. No mention is made of blending highly polymerized polyethylene glycol.
Furthermore, in the present invention, the highly polymerized polyethylene glycol of component (B) improves the astringency feeling and has an excellent effect of suppressing dripping. Polyethylene glycol as a moisturizing agent and a thickening agent for a dentifrice composition From the blending of the above, the above-mentioned exceptional effect by the combined use of the components (A) and (B) cannot be predicted.

Accordingly, the present invention provides the following dentifrice composition.
[1]
(A) 0.2 to 3% by mass of one or more aluminum compounds selected from potassium aluminum sulfate, aluminum ammonium sulfate and aluminum sulfate;
(B) The viscosity of a 5 W / V% aqueous solution at 25 ° C. measured with a Brookfield viscometer is 10 mPa · s or more, and the viscosity of a 2 W / V% aqueous solution at 25 ° C. measured with the viscometer is 800 mPa · s. (A) / (B) which contains 0.05-0.5 mass% of the following highly polymerized polyethylene glycol, and shows the ratio of the compounding quantity of (A) component and (B) component is mass ratio. dentifrice composition characterized 1-20 der Rukoto as.
[2]
The dentifrice composition according to [1], wherein the aluminum compound as component (A) is potassium aluminum sulfate and / or aluminum sulfate.
[3]
Furthermore, the dentifrice composition of [1] or [2] containing 0.5-5 mass% of surfactant.
[4]
Furthermore, the dentifrice composition in any one of [1]-[3] which is a toothpaste containing 5-50 mass% of abrasive | polishing agents.

  According to the present invention, there is provided a dentifrice composition containing a polyvalent metal compound having an improved astringent feeling-improving effect, giving a continuous astringent feeling, and suppressing dripping from the mouth of the preparation and having an excellent feeling of use. it can. The dentifrice composition of the present invention can be suitably used for the prevention or suppression of periodontal diseases by tightening the gums by astringency.

  The present invention will be described in detail below. The dentifrice composition of the present invention comprises (A) one or more aluminum compounds selected from potassium aluminum sulfate, ammonium ammonium sulfate and aluminum sulfate, and (B) 5 W / V% at 25 ° C. measured with a Brookfield viscometer. And a highly polymerized polyethylene glycol having a viscosity of 10 mPa · s or higher and a viscosity of a 2 W / V% aqueous solution at 25 ° C. measured by the viscometer of 800 mPa · s or lower.

The aluminum compound as component (A) is one or more selected from aluminum potassium sulfate, aluminum ammonium sulfate, and aluminum sulfate, and these are astringent components that give a feeling of convergence.
The aluminum compound is preferably aluminum potassium sulfate, aluminum ammonium sulfate, or aluminum sulfate, more preferably potassium aluminum sulfate (potash alum) or aluminum sulfate, particularly aluminum sulfate from the viewpoint of the feeling of use as a dentifrice composition. Potassium is preferred. This potash alum has been widely used as a food additive as a color-retaining agent for pickles and boiled foods, but recently it has been used in oral compositions as a component having an astringent action and a bactericidal action.

Specifically, commercially available products shown below can be used.
・ Aluminium sulfate potassium (Daimei Chemical Industry Co., Ltd., Potash alum (hydrate))
・ Aluminum ammonium sulfate (manufactured by Daimei Chemical Co., Ltd., ammonium alum)
・ Aluminum sulfate (Daimei Chemical Industry Co., Ltd.)

  (A) The compounding quantity of the aluminum compound of a component is 0.2 to 3% (mass%, hereafter the same) of the whole composition, Preferably it is 0.3 to 2% from the point of convergence. If it is less than 0.2%, sufficient convergence cannot be obtained, and if it exceeds 3%, dripping cannot be suppressed.

The highly polymerized polyethylene glycol (B) is a polymer compound having a structure in which ethylene glycol is polymerized, and is a 5 W / V (mass / volume (capacity))% aqueous solution at 25 ° C. measured with a Brookfield viscometer. The viscosity is 10 mPa · s or more, and the viscosity of a 2 W / V% aqueous solution at 25 ° C. measured with the viscometer is 800 mPa · s or less.
When the viscosity of the 5 W / V% aqueous solution exceeds 20,000 mPa · s, the viscosity cannot be measured, so the viscosity in the 2 W / V% aqueous solution is adopted. That is, in the present invention, highly polymerized polyethylene glycol has the following viscosity physical properties (1) or (2).
(1) The viscosity of a 5 W / V% aqueous solution at 25 ° C. is 10 to 20,000 mPa · s.
(2) In (1), when the viscosity exceeds 20,000 mPa · s, the viscosity of the 2 W / V% aqueous solution at 25 ° C. is 800 mPa · s or less. In the present invention, more preferable highly polymerized polyethylene glycol is 5 W at 25 ° C. The viscosity of the / V% aqueous solution is 10 to 18,000 mPa · s, particularly 30 to 10,000 mPa · s, especially 55 to 2,000 mPa · s.
In the present invention, by using highly polymerized polyethylene glycol having a viscosity within the above specific range as the component (B), the astringent feeling imparting effect is improved, the continuous astringent feeling is given, and the dripping suppression effect is excellent, Gives an excellent feeling of use.
When the viscosity of the 5 W / V% aqueous solution is less than 10 mPa · s, it does not contribute to the improvement of the astringent feeling imparting effect, the astringent feeling imparting effect is inferior, and the viscosity of the 2 W / V% aqueous solution exceeds 800 mPa · s. In addition, the dispersibility of the dentifrice composition is deteriorated and a sufficient astringency cannot be obtained, and the stability is lowered.

As the highly polymerized polyethylene glycol of component (B), the following commercially available products can be used.
・ POLYOX WSR N-10
(Manufactured by Dow Chemical Co., Ltd., viscosity of 5 W / V% aqueous solution: 12-50 mPa · s, measuring equipment: Brookfield RVT, rotor No. 1, rotation speed 50 rpm, measuring temperature 25 ° C., measuring time 0.5 minutes)
・ POLYOX WSR N-80
(Manufactured by Dow Chemical Co., Ltd., viscosity of 5 W / V% aqueous solution: 55 to 115 mPa · s, measuring equipment: Brookfield RVT, rotor No. 1, rotation speed 50 rpm, measuring temperature 25 ° C., measuring time 0.5 minutes)
・ POLYOX WSR N-750
(Viscosity of 5 W / V% aqueous solution manufactured by Dow Chemical Company: 1,000 to 1,200 mPa · s, measuring equipment: Brookfield RVF, rotor No. 2, rotation speed 10 rpm, measuring temperature 25 ° C., measuring time 1 minute )
・ POLYOX WSR-205
(Viscosity of 5 W / V% aqueous solution manufactured by Dow Chemical Company: 4,500-8,800 mPa · s, measuring equipment: Brookfield RVF, rotor No. 2, rotation speed 2 rpm, measuring temperature 25 ° C., measuring time 5 minutes )
・ POLYOX WSR-1105
(Viscosity of 5 W / V% aqueous solution manufactured by Dow Chemical Company: 8,800-17,600 mPa · s, measuring equipment: Brookfield RVF, rotor No. 2, rotation speed 2 rpm, measuring temperature 25 ° C., measuring time 5 minutes )
・ POLYOX WSR N-12K
(Manufactured by Dow Chemical Co., Ltd., viscosity of 2 W / V% aqueous solution: 400 to 800 mPa · s, measuring equipment: Brookfield RVF, rotor No. 1, rotation speed 10 rpm, measuring temperature 25 ° C., measuring time 1 minute)

  (B) The compounding quantity of the highly polymerized polyethylene glycol of a component is 0.05 to 0.5% of the whole composition, Preferably it is 0.1 to 0.3%. When the blending amount is less than 0.05%, it does not contribute to the sufficient improvement of the astringent feeling imparting effect and the improvement of the dripping, the astringent feeling is inferior, and the dripping cannot be suppressed. If it exceeds 0.5%, the dispersibility of the dentifrice composition is deteriorated and sufficient convergence cannot be obtained, and the stability may be deteriorated.

  In the present invention, the blending ratio of the aluminum compound of the component (A) and the highly polymerized polyethylene glycol of the component (B) is not particularly limited, but indicates the ratio of the blending amount of the component (A) and the component (B). (A) / (B) has a mass ratio of preferably 1-20, more preferably 2-15, and even more preferably 2-8. If it is within the above range, the astringent feeling imparting effect is more excellent and dripping is further suppressed. If the (A) / (B) ratio is too small, the astringent feeling imparting effect may be inferior, and if it is too large, dripping may not be sufficiently suppressed.

  The dentifrice composition of the present invention is suitably prepared as a toothpaste, a liquid dentifrice, and the like, particularly as a toothpaste. Moreover, the well-known component normally used besides the said component can be mix | blended as needed according to the dosage form. For example, abrasives, thickeners, binders, surfactants, sweeteners, preservatives, colorants, fragrances, active ingredients other than the above, and the like are used in normal amounts within a range that does not interfere with the effects of the present invention. Can do.

  Examples of the abrasive include silica-based abrasives such as silica gel, precipitated silica, aluminosilicate, zirconosilicate, calcium phosphate-based abrasives such as dicalcium phosphate, aluminum hydroxide, alumina, calcium carbonate, synthetic resin-based abrasives, etc. It is done. Among these, a silica-based abrasive is preferably blended because the stability of the dentifrice composition is improved. The blending amount of the abrasive is usually 5 to 50%.

  Examples of the thickener include sugar alcohols such as sorbit, xylit and erythritol, and polyhydric alcohols such as propylene glycol and glycerin. The amount of these thickeners is usually 5 to 50%.

  Examples of the binder include gums such as xanthan gum and cellulose derivatives such as sodium carboxymethyl cellulose. The amount of the binder is usually 0 to 5%, particularly 0.1 to 5%.

As the surfactant, an anionic surfactant, a cationic surfactant, a nonionic surfactant, and an amphoteric surfactant can be blended.
Examples of the anionic surfactant include alkyl sulfates such as sodium lauryl sulfate. Examples of nonionic surfactants include polyhydric acids such as sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters, sugar alcohol fatty acid esters such as sucrose fatty acid esters, glycerin fatty acid esters, polyglycerin fatty acid esters, and polyoxyethylene glycerin fatty acid esters. Examples include alcohol fatty acid esters, polyoxyethylene alkyl ethers, polyoxyethylene fatty acid esters such as polyoxyethylene hydrogenated castor oil, and fatty acid alkanolamides.
Examples of the cationic surfactant include alkylammonium type, and examples of the amphoteric surfactant include betaine type and imidazoline type.
The blending amount of the surfactant is preferably 0.5 to 5% of the entire composition.
In the present invention, dripping can be effectively suppressed even when a nonionic surfactant such as polyoxyethylene hydrogenated castor oil having a foam stabilizing action is not blended. The surfactant polyoxyethylene hydrogenated castor oil may not be blended.

  In the present invention, even when an alkyl sulfate salt such as sodium lauryl sulfate, which is a foaming component, is blended, the dripping of the dentifrice composition is suppressed, and an astringent feeling imparting effect and a feeling of use are excellent. The blending amount of the alkyl sulfate is desirably 5% or less, particularly 4% or less, particularly 3% or less of the entire composition.

  Examples of the sweetening agent include saccharin sodium. Examples of the preservative include paraoxybenzoic acid ester, benzoic acid or a salt thereof. Examples of the colorant include blue No. 1, yellow No. 4, and the like.

  Perfumes include peppermint oil, spearmint oil, anise oil, eucalyptus oil, winter green oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil, Lime oil, lavender oil, rosemary oil, laurel oil, camomil oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, grapefruit oil, sweetie Natural fragrances such as oil, coconut oil, Iris concrete, absolute peppermint, absolute rose, orange flower, and processing of these natural fragrances (front reservoir cut, rear reservoir cut, fractional distillation, liquid-liquid extraction, essence, powder Perfumes, etc.) and menthol, Rubon, Anethole, Cineol, Methyl salicylate, Synamic aldehyde, Eugenol, 3-1-Mentoxypropane-1,2-diol, Thymol, Linalol, Linarel acetate, Limonene, Menthone, Menthyl acetate, N-Substituted paramenthane 3-carboxamide, pinene, octyl aldehyde, citral, pulegone, carbyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allylcyclohexane propionate, methyl anthranilate, ethyl methyl phenyl glycidate, vanillin, undecalactone, Hexanal, butanol, isoamyl alcohol, hexenol, dimethyl sulfide, cycloten, furfural, trimethylpyrazine, ethyl lactate, ethyl Toothpaste compositions such as single flavors such as oacetate, and other flavors such as strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, butter flavor, milk flavor, fruit mix flavor, tropical fruit flavor, etc. The known perfume materials used can be used in combination. The blending amount of these fragrances is usually 0.00001 to 3%.

  As an active ingredient, the well-known thing normally mix | blended with a dentifrice composition can be used, For example, a fluoride, a disinfectant, an anti-inflammatory agent, an enzyme, a plant extract, a calculus inhibitor, an anti-plaque agent etc. can be mix | blended. Specifically, fluorides such as sodium fluoride and sodium monofluorophosphate, nonionic fungicides such as isopropylmethylphenol, cationic fungicides, enzyme tranexamic acids such as dextranase, epsilon aminocaproic acid, allantoin, etc. Anti-inflammatory agents, sodium chloride and the like. In addition, the said active ingredient can be mix | blended in an effective amount in the range which does not prevent the effect of this invention.

  EXAMPLES Hereinafter, although an Example, a comparative example, a formulation example is shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples, “%” means “% by mass” unless otherwise specified.

[Examples and Comparative Examples]
A dentifrice composition (toothpaste) having the composition shown in Tables 1 to 3 was prepared by a conventional method and evaluated by the following method. The results are shown in Tables 1-3.

(1) Evaluation method of astringency during use Sensory evaluation was performed using 10 professional panelists. The test dentifrice composition filled in the laminate tube was extruded 1 cm onto a toothbrush and mounted for 3 minutes in the same manner as usual, and the convergence feeling during use was determined according to the following criteria.
Score criteria:
4 points: I feel a sense of convergence very much 3 points: I feel a sense of convergence 2 points: I feel a little sense of convergence 1 point: I do not feel a feeling of convergence at all I evaluated the average value of the judgment results of 10 people according to the following criteria Those for which the evaluations of, ◎ and ○ were ensured were judged to be dentifrice compositions with a moderate astringency during use.
Evaluation criteria:
◎: Average point 3.5 points or more and 4.0 points or less ○: Average point 3.0 points or more and less than 3.5 points △: Average point 2.0 points or more and less than 3.0 points ×: Average point 1.0 points More than 2.0 points

(2) Evaluation method of convergence feeling after 5 minutes of use Sensory evaluation was performed using 10 professional panelists. The test dentifrice composition filled in the laminate tube was extruded 1 cm on a toothbrush and mounted for 3 minutes in the same way as usual, and the convergence feeling after 5 minutes from use was judged according to the following criteria.
Score criteria:
4 points: I feel a sense of convergence very much 3 points: I feel a sense of convergence 2 points: I feel a little sense of convergence 1 point: I do not feel a feeling of convergence at all I evaluated the average value of the judgment results of 10 people according to the following criteria What was evaluated as, ◎ and ○ was judged to be a dentifrice composition with a moderate astringency when 5 minutes passed after use.
Evaluation criteria:
◎: Average point 3.5 points or more and 4.0 points or less ○: Average point 3.0 points or more and less than 3.5 points △: Average point 2.0 points or more and less than 3.0 points ×: Average point 1.0 points More than 2.0 points

(3) Evaluation method of absence of dripping from mouth during use Sensory evaluation was performed using 10 professional panelists. The test dentifrice composition filled in the laminate tube was extruded 1 cm onto a toothbrush and mounted for 3 minutes in the same manner as usual, and the dripping from the mouth during use was judged according to the following criteria.
Score criteria:
4 points: no dripping at all 3 points: slightly dripping 2 points: dripping 1 point: dripping drastically The average value of the judgment results of 10 people was evaluated according to the criteria shown below. What was ensured to be evaluated was judged to be a dentifrice composition that was difficult to drip from the mouth during use and had a good feeling of use.
Evaluation criteria:
◎: Average point 3.5 points or more and 4.0 points or less ○: Average point 3.0 points or more and less than 3.5 points △: Average point 2.0 points or more and less than 3.0 points ×: Average point 1.0 points More than 2.0 points

Details of the raw materials used are shown below. The viscosity of the highly polymerized polyethylene glycol is the viscosity at 25 ° C. measured with a Brookfield viscometer (Brookfield RVT or RVF), as described above. Further, the viscosity of polyethylene glycol # 4000 measured by the same method was less than the viscosity of (B) highly polymerized polyethylene glycol.
(A) Potassium aluminum sulfate; manufactured by Daimyo Chemical Industry Co., Ltd., Potash alum (hydrate)
(A) Aluminum sulfate; Daimyo Chemical Co., Ltd. (B) highly polymerized polyethylene glycol;
POLYOX WSR N-80
(Viscosity of 5 W / V% aqueous solution manufactured by Dow Chemical Company: 85 mPa · s (rotor No. 1
, Rotation speed 50rpm, measurement time 0.5min))
POLYOX WSR N-10
(Viscosity of 5 W / V% aqueous solution manufactured by Dow Chemical Company: 35 mPa · s (rotor No. 1
, Rotation speed 50rpm, measurement time 0.5min))
POLYOX WSR N-750
(Viscosity of 5 W / V% aqueous solution manufactured by Dow Chemical Company: 1,100 mPa · s (Rotor N
o. 2, rotation speed 10rpm, measurement time 1min))
POLYOX WSR N-12K
(Viscosity of 2 W / V% aqueous solution manufactured by Dow Chemical Company: 420 mPa · s (rotor no.
1, rotation speed 10rpm, measurement time 1min))
Polyethylene glycol # 4000
(Average molecular weight 2,600-3,8 described in Sanyo Chemical Industries, Ltd., quasi-drug raw material standard 2006
00)
In addition, content of potassium aluminum sulfate in the table is a pure conversion value.

  The formulation examples are shown in Table 4 below. The toothpaste compositions of the prescription examples both felt moderate astringency during use and after 5 minutes of use, and the use feeling was good because the dripping from the mouth during use was suppressed.

Claims (4)

(A) 0.2 to 3% by mass of one or more aluminum compounds selected from potassium aluminum sulfate, aluminum ammonium sulfate and aluminum sulfate;
(B) The viscosity of a 5 W / V% aqueous solution at 25 ° C. measured with a Brookfield viscometer is 10 mPa · s or more, and the viscosity of a 2 W / V% aqueous solution at 25 ° C. measured with the viscometer is 800 mPa · s. (A) / (B) which contains 0.05-0.5 mass% of the following highly polymerized polyethylene glycol, and shows the ratio of the compounding quantity of (A) component and (B) component is mass ratio. dentifrice composition characterized 1-20 der Rukoto as.   The dentifrice composition according to claim 1, wherein the aluminum compound (A) is potassium aluminum sulfate and / or aluminum sulfate. Furthermore, the dentifrice composition of Claim 1 or 2 containing 0.5-5 mass% of surfactant. Furthermore, it is a toothpaste containing 5-50 mass% of abrasive | polishing agents, The dentifrice composition of any one of Claims 1-3.