JP6218352B2 - Display device, display method and display program used in measurement system - Google Patents

Description

  The present invention relates to a display device, a display method, and a display program used in a measurement system that measures light generated from a luminescent or fluorescent substance contained in a liquid to be measured or radiation contained in the liquid to be measured. About.

  The measurement system is used, for example, in a liquid collection device. As an example of the liquid collection device, a blood collection device for collecting blood, that is, collecting blood will be described. The blood collection device is used for quantitative analysis in nuclear medicine diagnosis (for example, PET (Positron Emission Tomography), SPECT (Single Photon Emission CT), etc.), and in particular, the radioactivity concentration in arterial blood of small animals (eg, mice, rats, etc.). Used for measurement.

Specifically, blood is collected (collected) after administration of a radiopharmaceutical to a small animal, and plasma separation is performed by centrifugation after completion of the whole blood collection at a predetermined time. Changes in radioactivity concentration in whole blood and plasma over time Is measured (for example, see Patent Documents 1 and 2). More specifically, the measurement is performed using an imaging plate (IP: Imaging Plate) that exposes β ⁺ rays contained in blood to visualize the radioactivity distribution. As software for acquiring a radiation dose value from an IP image obtained from an imaging plate (abbreviated as “IP” as appropriate), there is Multi Gauge manufactured by Fuji Film, for example. With this software, the radiation dose per unit area can be obtained by reading an IP image, setting a region of interest on the software, and calculating a pixel value in the region of interest.

  In Patent Document 1, a sample (here, blood) that radiates radioactivity is placed in a container partitioned by a predetermined dimension, the radiation intensity of the sample is measured by IP, and the area of the sample is measured by a scanner. Since the container is designed with a predetermined dimension, the volume of the sample is obtained from the area of the sample as a measurement result. A technique for calculating the radioactivity concentration (= radiation intensity / volume) of each sample by combining an IP image of radiation intensity acquired by IP and a scanner image acquired by a scanner is shown. In Patent Document 2, an example of a container partitioned by a predetermined dimension is shown, and a container in which a flow path for putting a plurality of samples into a flat disk is formed.

  When determining the blood radioactivity concentration, it is processed in the following flow. That is, blood to be measured is collected in a flow path of a disc (also called “CD well”). Plasma separation is performed by rotating the disc and centrifuging to separate blood into plasma and blood cells. The disk is imaged with a flat head scanner, and image data (scanner image) is acquired.

  Each flow path of the disk is formed by grooving with a predetermined dimension with respect to the disk, so if the groove length or groove region of the blood fed into the flow path is known, the flow path has a predetermined dimension. The volume of blood fed into the flow path can be defined based on the cross-sectional area of the groove that has been grooved or the depth of the groove. The acquired image data (scanner image) of the disc is read by the above-described software, and the flow path position, the boundary between plasma and gas from which blood in the flow path is separated, and the boundary between plasma and blood cells are displayed on the CPU ( It is automatically detected by an algorithm by a central processing unit). The boundary can be automatically detected by a Sobel filter or the like. At this time, as shown in FIG. 10, the boundary line L is superimposed on the image data so that the position of the detected boundary can be seen. For convenience of illustration, although hatching or the like is shown in FIG. 10, plasma, blood cells, and gas are projected on the scanner image in an actual scanner image.

The groove length is determined from the position of the boundary line L, and the volume of each part of plasma and blood cells is obtained from the groove length and the cross-sectional area of the flow path. On the other hand, the IP image acquired by the IP, performs superimposition processing by superimposing the above-described scanner image, from counting information part of the beta ⁺ line which overlaps with the plasma and blood cell on IP image, each part of the beta ⁺ line By subtracting the volume of each part from the radiation intensity, the blood radioactivity concentration per unit volume is obtained.

International Publication No. WO2009-093306 Japanese Patent Application Laid-Open No. 2011-074420

However, when the boundary position is automatically detected, there is a problem that the automatically detected boundary position is deviated from the actual boundary position (obtained by imaging).
That is, dust, dust, or scratches on the surface of the CD well are reflected in the scanner image captured by the flat head scanner, or the boundary surface of gas / plasma or plasma / blood cells is mixed and unclear and blurred. An erroneous detection occurs in which the automatically detected boundary position deviates from the actual boundary position.

  The present invention has been made in view of such circumstances, and an object thereof is to provide a display device, a display method, and a display program used in a measurement system that can easily determine the presence or absence of a false detection. To do.

  As a result of earnest research to solve the above problems, the inventors have obtained the following knowledge.

That is, in the case of erroneous detection, each region should be able to be accurately obtained by correcting (adjusting) the above-described boundary line to the correct boundary position. However, it is difficult to distinguish whether the boundary line is located at the actual boundary position or whether a false detection has occurred. Taking the case of plasma separation as an example, when the boundary between gas and plasma is actually detected as a boundary between plasma and blood cells, the displayed boundary is the boundary between gas and plasma. It is difficult to distinguish whether it is displayed or the boundary between plasma and blood cells.

  This may be due to manually setting the boundary line. Then, instead of displaying the manually set boundary line, in addition to the image obtained by actual imaging, if the data obtained based on the algorithm by the CPU is displayed separately, false detection will occur. The knowledge that the presence or absence can be easily determined was obtained.

The present invention based on such knowledge has the following configuration.
That is, the display device used in the measurement system according to the present invention is a measurement system that measures light generated from a luminescent or fluorescent substance contained in a liquid to be measured or radiation contained in the liquid to be measured. A display device used for
An image obtained by imaging the measurement object is displayed, and a flow path region relating to a flow path of a container provided for containing the liquid to be measured is extracted as an extraction result extracted by an algorithm for the image. The flow path region is formed by a surrounding area surrounding the flow path on the image and a filled area that fills the flow path on the image with a color. And the extraction result display means for filling and displaying the flow path by the filled area, and at least one of the image and the flow path area as the extraction result is manually moved on the display screen. adjustment, or characterized in that it comprises an image-extraction result adjusting means for manually adjusting the size of the channel region and the extraction result on the display screen Than is.

[Operation / Effect] According to the display device used in the measurement system of the present invention, an image obtained by imaging an object to be measured is displayed, and a liquid to be measured is obtained as an extraction result extracted by an algorithm for the image. The flow channel region relating to the flow channel of the container provided to contain the image is added to the image and displayed, and the flow channel region is filled with the color of the enclosing region surrounding the flow channel on the image and the flow channel on the image. An extraction result display means that is formed by a filled area and surrounds and displays the flow path by the enclosed area and also displays the flow path by the filled area, and is extracted by an algorithm into an image obtained by actual imaging. By adding and displaying the flow channel region formed by the enclosed region and the filled region as the extraction result, the flow channel region as the extraction result is Even if each area of the image obtained by imaging at the time is misdetected because it does not match due to dust, dirt, scratches, etc., at least it is easily determined by the surrounding area and the filled area that there was a misdetection can do. In addition, when the flow path region as the extraction result matches each region of the image obtained by actual imaging, it can be easily determined that there is no false detection based on the surrounding region and the painted region. As a result, it is possible to easily determine the presence or absence of erroneous detection based on the flow channel region (enclosed region and filled region) as the extraction result extracted by the algorithm. In addition, by providing an image / extraction result adjustment means for manually adjusting at least one of the image and the extraction result flow path area on the display screen, the flow area indicated as the extraction result having the erroneous detection is imaged. Can be matched relatively, manually adjust the flow area as the extraction result extracted by the algorithm, and emphasize the display of each area of the image by the flow area as the adjusted extraction result can do.

  It should be noted that the color to be filled is not limited to a colored color, but includes a color filled with a color (for example, a transparent color or a semi-transparent color) according to the pixel value of the image.

The display method according to the present invention also provides measurement data obtained by measuring light generated from a luminescent or fluorescent substance contained in a liquid to be measured or radiation contained in the liquid to be measured. A display method for displaying an image obtained by imaging the measurement object, and a container provided for containing the liquid to be measured as an extraction result extracted by an algorithm for the image A flow channel region related to the flow channel is added to the image and displayed, and the flow channel region is formed by a surrounding region surrounding the flow channel on the image and a filled region that fills the flow channel on the image with a color. , as well as enclosure displaying the flow path by the surrounding region, and the extraction result display step of displaying fill the flow path by the filled area, the image, and the extraction result Image-extraction result adjustment process and manually adjust in the flow path adjusting moved manually in either at least one display screen area, or the extraction results and the display screen on the size of the channel region It is characterized by providing.

Further, the display program according to the present invention provides measurement data obtained by measuring light generated from a luminescent or fluorescent substance contained in a liquid to be measured or radiation contained in the liquid to be measured. A display program for causing a computer to execute a series of processing to be displayed, displaying an image obtained by imaging with respect to the measurement object, and extracting the result of the measurement with respect to the image as an extraction result extracted by an algorithm. A flow channel region relating to a flow channel of a container provided for containing a liquid is added to the image and displayed, and the flow channel region is surrounded by a surrounding region surrounding the flow channel on the image and the flow channel on the image Is formed by a color-filled area, the flow path is surrounded by the enclosed area, and the flow path is filled by the filled area. And Shimesuru extraction result display step, the size of the image, the extraction result and the said channel region either adjusted manually moved at least one display screen, or set to the extracted result of the channel region And an image / extraction result adjustment step for manually adjusting the image on the display screen .

[Operation / Effect] According to the display method and display program of the present invention, in the extraction result display step, the image obtained by imaging the measurement object is displayed, and the extraction result extracted by the algorithm for the image is as follows: A flow channel region relating to a flow channel of a container provided to store the liquid to be measured is added to the image and displayed, and the flow channel region is surrounded by a surrounding region surrounding the flow channel on the image and the flow channel on the image. The flow area as the extraction result was obtained by actual imaging by displaying the flow path with the enclosed area and displaying the flow path with the filled area. Whether each area of the image matches or does not match can be easily discriminated from the surrounding area and the filled area. As a result, it is possible to easily determine the presence or absence of erroneous detection based on the flow channel region (enclosed region and filled region) as the extraction result extracted by the algorithm. Also, by manually adjusting on the display screen in the image / extraction result adjustment process, the flow path area that is the erroneous detection result can be matched relatively to the image, and extracted with an algorithm. It is possible to manually adjust the flow channel region as the extracted result, and to emphasize the display of each region of the image by the flow channel region as the adjusted extraction result.

  In these display devices described above, it is preferable that the extraction result display means displays the component obtained as an extraction result by adding a component region to each component obtained by centrifuging the liquid to be measured on the image. . By adding the component area extracted by the algorithm to each component on the image and displaying it, it is possible to easily determine whether or not each component on the actual image matches the component area extracted by the algorithm. it can.

  An example of the component area (an example of the former) is a surrounding area surrounding each component on the image, and the extraction result display unit separately displays each component by surrounding the surrounding area. Alternatively, another example of the component area (an example of the latter) is a filled area in which each component on the image is filled with a color, and the extraction result display unit fills and displays each component separately in the filled area. As described in the flow channel region, the color to be painted is not limited to colored. In addition, the former example and the latter example may be combined, and each component may be separately enclosed and displayed by the surrounding area, and each component may be separately filled and displayed by the filling area for the inner portion.

According to the display device used in the measurement system according to the present invention, an image obtained by imaging an object to be measured is displayed, and the liquid to be measured is accommodated as an extraction result extracted by an algorithm for the image. The flow channel area related to the flow path of the container provided in is added to the image and displayed, and the flow path area is formed by a surrounding area surrounding the flow path on the image and a filled area that fills the flow path on the image with a color. In addition, by providing an extraction result display means for enclosing and displaying the flow path with the enclosed area and displaying the flow path with the filled area, the flow area (enclosed area and filled area) as the extraction result extracted by the algorithm is provided. ) To easily determine the presence or absence of false detection.
Further, according to the display method and the display program of the present invention, in the extraction result display step, an image obtained by imaging the measurement target is displayed, and the extraction result of the measurement target is displayed as an extraction result extracted by an algorithm for the image. A flow channel region related to the flow channel of the container provided to contain the liquid is added to the image and displayed, and the flow channel region is indicated by the color of the surrounding region surrounding the flow channel on the image and the flow channel on the image. The flow area (enclosed area and filled area) as the extraction result extracted by the algorithm by forming the filled area and surrounding the flow path with the enclosed area and displaying the flow path with the filled area. Based on this, it is possible to easily determine the presence or absence of erroneous detection.

It is a schematic perspective view of the blood collection apparatus and measurement apparatus which concern on an Example. It is a block diagram of the measuring apparatus which concerns on an Example. It is a schematic perspective view of the scanner in the imaging part of a measuring device. It is a schematic plan view of the disc which concerns on an Example. It is a block diagram of the display apparatus which concerns on an Example. It is an example of the display form in the output monitor of a display apparatus. It is a schematic plan view of the fixing jig which concerns on an Example. (A)-(d) is the figure which added each example of the extraction result (flow-path area | region) to the scanner image. It is the flowchart which showed the flow of a series of processes which concern on an Example. It is the figure which superimposed the conventional boundary line on image data.

Embodiments of the present invention will be described below with reference to the drawings.
1 is a schematic perspective view of a blood collection device and a measurement device according to an embodiment, FIG. 2 is a block diagram of the measurement device according to the embodiment, and FIG. 3 is a schematic perspective view of a scanner in an imaging unit of the measurement device. FIG. In the present embodiment, blood will be described as an example of a liquid to be measured, and a system including a blood collection device and a measurement device as a measurement system will be described as an example.

  As shown in FIG. 1, the blood collection apparatus 10 according to the present embodiment collects blood to be measured by separating it in time series. In addition, a measuring device 30 that measures radiation (for example, β rays, γ rays, etc.) contained in blood collected by the blood collecting device 10 is provided around the blood collecting device 10.

  The blood collection apparatus 10 includes a microfluidic device (liquid dividing device) 40 configured by vertically stacking two PDMS substrates 11 and 12 made of PDMS resin (Polydimethylsiloxane). The PDMS substrates 11 and 12 are grooved with a predetermined dimension, and the main flow path 13 and the side paths 41, 42, and 43 are formed by the grooves. Here, the material of the blood collection device 10 is not limited to PDMS, and may be any material that is optically transparent such as acrylic, polycarbonate, COP (cycloolefin polymer).

  A catheter 14 is disposed on the blood inlet side of the main channel 13, and the main channel 13 and the catheter 14 are connected via a connector 15. Blood is continuously fed from the catheter 14 into the main channel 13 and the amount of inflow is controlled by a valve (not shown). A blood pipe 16 is disposed on the blood outlet side of the main flow path 13, and the main flow path 13 and the blood pipe 16 are connected via a connector 17.

  A light source 21 and a photodiode 22 are disposed across the main flow path 13. The blood flowing in the main flow path 13 or heparin solution described later is irradiated with light from the light source 21, and the photodiode 22 detects the light shielding by the blood, so that the blood or heparin solution is optically monitored (monitored) as described later. Measure length information of blood or heparin solution. Here, the light source 21 and the photodiode 22 have been described as an example of the optical measurement means. However, any means for measuring the liquid interval while optically monitoring the liquid to be measured can be used as the light source 21 and the photodiode 22. It is not limited. For example, volume information of the liquid to be measured may be acquired by a CCD camera. In addition, the light source 21 and the photodiode 22 are so-called “transmission type sensors” that are arranged to face each other with the main flow channel 13 interposed therebetween as shown in FIG. On the other hand, a so-called “reflective sensor” may be used in which light detection means typified by a photodiode is provided on the same side, and detection is performed using reflected light from blood.

  On the other hand, a nozzle 23 is connected to the downstream side of the blood pipe 16 described above. As the nozzle 23, a capillary tube such as an injection needle or a glass tube is used. Here, although the nozzle 23 is used as the discharge unit for discharging the liquid, a dispenser may be used. A disk (also called “CD well”) 24 that receives and stores blood dropped from the nozzle 23 is provided. On the central side of the disc 24, flow path inlets 25 (also see FIG. 4) each having a plurality of openings for receiving the dropped blood are arranged radially. Similarly to the PDMS substrates 11 and 12 described above, the circular plate 24 is also grooved, and a plurality of U-shaped flow paths 26 each having a U-shaped groove (FIG. 4). Are also formed radially. Each U-shaped channel 26 is connected to the outer end of the above-described channel inlet 25 on a one-to-one basis, and each U-shaped channel 26 is formed to extend in the radial direction of the disk 24. . Thus, by interposing the nozzle 23, the disc 24 is formed so that blood can flow through the main flow path 13. The disc 24 corresponds to the container in the present invention, and the U-shaped channel 26 corresponds to the channel in the present invention. A specific configuration of the disc 24 will be described later with reference to FIG.

On the other hand, the measuring device 30 includes a reading unit 31. The reading unit 31 is provided with a cover for inserting the exposed imaging plate IP, and detects β ⁺ rays contained in the blood by reading the light excited from the imaging plate IP. . Specifically, as shown in FIG. 1B, the reading unit 31 includes a laser light source 32 and a photomultiplier tube (photomultiplier tube) 33, and a laser is applied from the laser light source 32 to the imaging plate IP. , And the photomultiplier tube 33 converts the light excited by the laser irradiation of the imaging plate IP into electrons and multiplies them, thereby detecting β ⁺ rays simultaneously two-dimensionally.

  Subsequently, a block diagram of the measuring apparatus 30 will be described. As shown in FIG. 2, the measuring device 30 includes an imaging unit 34 and a display device 35 in addition to the reading unit 31 described above. The display device 35 may be configured by a normal personal computer. The display device 35 corresponds to the display device in this invention. A specific configuration of the display device 35 will be described later with reference to FIG.

  As shown in FIG. 3, the imaging unit 34 images the disc 24. In this embodiment, a flat head scanner is employed as the imaging unit 34. A flat head scanner is composed of a linear light source 34a having at least a length corresponding to the diameter of the disc 24 and a linear photodiode array (that is, a line sensor) 34b arranged to face the light source 34a with the disc 24 in between. Configure. The disk 24 is imaged by scanning the disk 24 with a flat head scanner, and an image of the disk 24 is acquired.

  Returning to the description of FIG. 1, as described above, the microfluidic device 40 includes the main flow path 13 for feeding blood, the side path 41 for feeding a heparin solution which is a kind of anticoagulant for preventing the occurrence of blood coagulation, A side path 42 for feeding air or gas and a side path 43 for discharging blood or heparin solution are provided.

  A cleaning liquid pipe 44 is disposed on the solution inlet side of the side path 41, and the side path 41 and the cleaning liquid pipe 44 are connected via a connector 45. If necessary, the heparin solution is poured into the main flow path 13 from the cleaning liquid pipe 44 via the side path 41 to clean the flow path. The inflow of heparin solution is controlled by a valve. Anticoagulants are not limited to heparin solutions.

  A bubble piping 46 is disposed on the gas inlet side of the side passage 42, and the side passage 42 and the bubble piping 46 are connected via a connector 47. The inflow time of air or gas controlled by a pressure generator (not shown) is adjusted by a valve and sent to the main flow path 13 through the side path 42. The bubbles are used to extract blood based on blood length information and to discharge waste liquid (blood, heparin solution, or a mixture thereof) remaining in the flow path of the microfluidic device 40. Here, the gas to be fed is not limited, and may be any gas that does not react with blood or heparin solution, as exemplified by rare gas such as helium, neon, and argon, or nitrogen gas.

  The bubble pipe 46 sends gas (for example, air or gas) through the side passage 14 to the main flow path 13 and inserts the gas as bubbles at a specified predetermined interval, whereby the blood to be measured is timed. Separated in series and sent to the disc 24. That is, the bubbles serve as a separator. In addition, although gas was used as a separator, it is not limited to gas, and there is little possibility of mixing with the liquid to be measured (blood in this embodiment), or if there is no possibility, the liquid to be measured May use another liquid as a separator. When the liquid to be measured is blood as in this embodiment, a liquid that does not mix with blood, such as mineral oil or fluorine oil, may be used as the separator. However, when a liquid is used as a separator, it can be used as a separator because it comes into contact with blood, but it is not desirable in that it is sent to the disk 24 and collected.

  A waste liquid pipe 48 is provided on the side of the waste liquid outlet side of the side path 43, and the side path 43 and the waste liquid pipe 48 are connected via a connector 49. The discharge amount is adjusted by a valve, and blood other than blood to be collected, heparin solution after channel cleaning, or a mixed solution thereof is discharged as waste liquid.

  Further, a valve is disposed downstream of the connector 15 of the main flow path 13, and a valve is disposed upstream of the connector 17, the light source 21, and the photodiode 22 of the main flow path 13. A valve is disposed downstream of the connector 45 of the side passage 41, and a valve is disposed downstream of the connector 47 of the side passage 42. A valve is disposed upstream of the connector 49 in the side passage 43.

  Next, a specific configuration of the disc 24 will be described with reference to FIG. 4 including FIG. FIG. 4 is a schematic plan view of a disk according to the example. As shown in FIG. 4, the U-shaped flow path 26 of the disk 24 is formed by connecting the flow path inlet 25 and the air hole 27 described above. When the flow channel inlet 26 that is a blood inlet is the upstream portion of the blood and the air hole 27 is the downstream portion, the U-shaped flow channel 26 extends inward in the radial direction of the disk 24 from the upstream portion to the downstream portion. The U-shape is formed by extending from the outside toward the outside, turning back and extending from the outside toward the inside in the radial direction of the disc 24. A plurality of such U-shaped flow paths 26 are provided.

  The disc 24 has two recesses 24A and 24B, which are fitted into a fixing jig 61 (see FIG. 7) described later. The fixing jig 61 will be described later with reference to FIG.

  As shown in FIG. 1, a motor 28 that rotates the disc 24 is provided at the center of the disc 24. By connecting the rotating shaft 29 of the motor 28 to the disc 24, the centrifugal force of the disc 24 by the motor 28 is used to perform blood separation to separate blood into plasma and blood cells.

  In this embodiment, the disc 24 is formed of an acrylic plate. The material of the circular plate 24 is not limited to acrylic, and any resin optically transparent material such as the above-described PDMS, polycarbonate, COP may be used.

  Next, a specific configuration of the display device 35 will be described with reference to FIGS. 5 and 6. FIG. 5 is a block diagram of the display device according to the embodiment, and FIG. 6 is an example of a display form on the output monitor of the display device. As shown in FIG. 5, the display device 35 includes a first reading unit 36 </ b> A, a second reading unit 36 </ b> B, a memory unit 37, a controller 38, an input unit 39, and an output monitor 50. The input unit 39 corresponds to the image / extraction result adjusting means in this invention.

  The first reading unit 36A and the second reading unit 36B are configured by a reading device such as an I / O (Input / Output) device, for example. The first reading unit 36A reads an IP image acquired by the imaging plate IP (see FIG. 1) via the reading unit 31 (see FIGS. 1 and 2). The second reading unit 36B reads the scanner image acquired by the imaging unit 34.

  The memory unit 37 is composed of a storage medium represented by ROM (Read-only Memory), RAM (Random Access Memory), and the like. In this embodiment, a display program 37A for causing a computer (controller 38 in this embodiment) to execute the series of processes shown in FIG. 9 and an image obtained by imaging such as an IP image or a scanner image are processed. The memory unit 37 includes an extraction result memory unit 37B that stores the flow channel region as an extraction result extracted by the algorithm. The display program 37A is composed of ROM, and the extraction result memory unit 37B is composed of RAM. Specifically, the flow channel region is a flow channel region in the U-shaped flow channel 26 (see FIGS. 1 and 4) of the disc 24 (see FIGS. 1, 3 and 4). Further, in this embodiment, as an extraction result, in addition to the flow channel region, components in each component (plasma and blood cells in this embodiment) obtained by centrifuging the liquid to be measured (blood in this embodiment) A description will be given by taking a region as an example. The display program 37A corresponds to the display program in the present invention.

  The controller 38 includes a central processing unit (CPU). A program for performing various image processing, a program for calculating a radioactivity concentration, a display program 37A shown in FIG. 5 and the like are executed by the controller 38 so that image processing and display program 37A corresponding to the program are executed. A series of processes shown in FIG. 9 (reading control to the first / second reading units 36A and 36B, display mode on the output monitor 50) are performed. As various types of image processing, the controller 38 has a function of reduction / enlargement processing for reducing and enlarging the scanner image, or a function of edge enhancement for enhancing the contour of the scanner image and outputting an edge-enhanced image. . Further, the controller 38 has a function of performing calculation (algorithm) processing based on the contour-enhanced image and outputting a flow channel region (other component region) as the extraction result described above.

  The input unit 39 includes a pointing device represented by a mouse, a keyboard, a joystick, a trackball, a touch panel, and the like. In the present embodiment, the input unit 39 displays each image reduced and displayed on the reduction screens 52, 53, and 54 (see FIG. 6), which will be described later, in order to enlarge the display on a main screen 51 (see FIG. 6) described later. Image selection function for selecting images, images obtained by imaging such as IP images and scanner images, and at least one of the flow path areas as extraction results are adjusted on the display screen, or extracted results It has a function of an image / extraction result adjusting means for adjusting the size of the flow path region on the display screen.

  As shown in FIG. 6, the output monitor 50 includes a main screen 51 for enlarging and displaying a main image, a reduction screen 52 for reducing and displaying an IP image, a reduction screen 53 for reducing and displaying a scanner image, And a reduction screen 54 for reducing and displaying an image after the superimposition process obtained by superimposing the scanner images. In FIG. 6, the IP image read by the first reading unit 36 </ b> A and the scanner image read by the second reading unit 36 </ b> B are superimposed and displayed on the main screen 51. On the main screen 51, a flow path region as an extraction result is added to the image and displayed. The main screen 51 corresponds to the extraction result display means in this invention.

  Next, a specific configuration of the fixing jig 61 will be described with reference to FIG. FIG. 7 is a schematic plan view of the fixing jig according to the embodiment. A fixing jig 61 is provided as shown in FIG. 7 in order to support the circular plate 24 (see FIGS. 1, 3, and 4) while fixing and positioning. The fixing jig 61 is provided with an opening 62 into which the disk 24 is fitted, and the opening 62 is provided with two protrusions 62A and 62B. By fitting the recess 24A (see FIG. 4) of the disc 24 into the projection 62A and fitting the recess 24B (see FIG. 4) of the disc 24 into the projection 62B, the fixing jig 61 becomes a circle. The plate 24 is fixed and supported while positioning.

  In this embodiment, as shown in FIG. 7, one opening 62 is provided, and one disk 24 is fixed to one fixing jig 61. However, a plurality of (for example, two) openings 62 are provided. In addition, the plurality of disks 24 may be fixed to one fixing jig 61. Further, a notch 61A is provided in the fixing jig 61 at the upper left of the drawing.

  In the case of the fixing jig 61 shown in FIG. 7, if it is rotated by 180 °, there is a possibility that the upper and lower sides and the right and left may be mistaken due to the symmetry of the flow path inlet 26 (see FIG. 1 and FIG. 4). The IP image acquired by the imaging plate IP (see FIG. 1) via the reading unit 31 (see FIG. 1 and FIG. 2) and the scanner image acquired by the imaging unit 34 The orientation can be aligned with reference to the notch 61A.

  The fixing jig 61 fixes and positions the disc 24 separated into plasma and blood cells by the centrifugal force of the disc 24 (see FIG. 1, FIG. 3 and FIG. 4) by the motor 28 (see FIG. 1). By supporting while performing, the direction and position of each flow path inlet 26 (refer FIG. 1 and FIG. 4) of the disc 24 are also fixed. Then, in a state where the orientation and position are fixed, the imaging plate 34 (see FIG. 1) is used to capture an image of the disk 24 to obtain an IP image, and the imaging unit 34 (FIGS. 2, 3, and 5). The image of the disk 24 is captured by the flat head scanner of FIG. Note that the order of imaging is not particularly limited.

More specifically, the disk 24 (see FIGS. 1, 3, and 4) and the fixing jig 61 are used as samples to open and accommodate a cassette (not shown), and an imaging plate IP (see FIG. 1) and the cassette is closed for exposure. By this exposure, electrons are captured by lattice defects of the phosphor (not shown) of the imaging plate IP due to the ionizing ability of β ⁺ rays contained in the blood. After exposure for a fixed time, the imaging plate IP is taken out of the cassette and inserted into the cover portion of the reading unit 31 (see FIGS. 1 and 2) of the measuring device 30 (see FIG. 1), and light is applied to the imaging plate IP. Irradiate to perform exposure.

A laser is irradiated to the imaging plate IP (see FIG. 1) from a laser light source 32 (see FIGS. 1 and 2) of the reading unit 31 (see FIGS. 1 and 2). The trapped electrons are excited to the conductor by this irradiation and recombine with holes, and are excited as light from the phosphor. The photomultiplier tube 33 (see FIGS. 1, 2, and 5) converts the light excited by the laser irradiation to the imaging plate IP into electrons and multiplies it, thereby two-dimensionally as an electric pulse. Simultaneously detect and count. In addition, after irradiating the imaging plate IP from the laser light source 32, the captured electrons are erased by irradiating the imaging plate IP with light from an erasing light source (not shown) for reuse. Based on the count information of the obtained beta ⁺ line in the imaging plate IP and reading unit 31, obtains the radiation dose in the blood which is count information on beta ⁺ line. In this way, an IP image is acquired.

  On the other hand, the imaging unit 34 (see FIG. 2, FIG. 3, and FIG. 5) is configured so that the plasma and blood cells separated from the plasma are a disc 24 (see FIG. 1, FIG. 3, and FIG. 4) and a fixing jig that supports the disc 24. 61 is imaged. By irradiating light from the light source 32a (see FIG. 3) of the flat head scanner of the imaging unit 34, plasma and blood cells appear as a difference in density on the imaged image due to the difference in absorbance and easily on the image. Be identifiable. In this way, a scanner image is acquired.

  Since the scanner image is a morphological information image including blood, the disc 24 (see FIGS. 1, 3 and 4) and the fixing jig 61 provided with the notch 61A, information such as the notch 61A is also reflected. However, since the IP image is a measurement information image having measurement information, information such as the cutout 61A is not reflected in the image. However, since the direction and position of each flow path inlet 26 (see FIGS. 1 and 4) are fixed by the fixing jig 61, the U-shaped flow path 26 of the disk 24 (which is the fixed position of the disk 24). And the relative position of the fixing jig 61 are also determined.

  However, even if the fixing jig 61 is provided, as described above, the surface of the CD well (that is, the disc), scratches, dust, dust, etc. are flat on the imaging unit 34 (see FIGS. 2, 3, and 5). If it is reflected in the scanner image captured by the head scanner, the boundary position of gas / plasma or plasma / blood cell may be erroneously detected. Further, when the disk 24 (see FIGS. 1, 3, and 4) is tilted together with the fixing jig 61 when imaging with the flat head scanner, the U-shaped flow path (FIGS. 1 and 4) of the disk 24 is changed. The flow channel position and flow channel region in (see Fig. 1) cannot be detected correctly, and may be detected out of alignment with the actual flow channel position and flow channel region.

  Therefore, the flow path region is added to the image (here, the scanner image) and displayed as the extraction result extracted by the algorithm. Each example of the extraction result will be described with reference to FIG. FIGS. 8A to 8D are diagrams in which each example of the extraction result (flow channel region) is added to the scanner image. 8A and 8C, a component area 72 is added to the scanner image in addition to the flow path area 71 as the extraction result. In FIG. 8B and FIG. 8D, a flow channel region 71 as an extraction result is added to the scanner image. The code | symbol BP in FIG. 8 shows plasma, and code | symbol BC shows a blood cell. In FIG. 8, since it is black and white, the color to be painted is distinguished by hatching or the like, but it is actually colored. However, it is not limited to colored.

  Next, a series of processes will be described with reference to FIG. 9 and will be described in conjunction with FIG. FIG. 9 is a flowchart illustrating a flow of a series of processes according to the embodiment.

  First, an IP image is acquired from the imaging plate IP (see FIG. 1) via the reading unit 31 (see FIGS. 1 and 2), and the imaging unit 34 (see FIGS. 2, 3, and 5). A scanner image is acquired from a flat head scanner.

(Step S1) Image Reading The second reading unit 36B (see FIG. 5) reads the scanner image acquired by the imaging unit 34 (see FIGS. 2, 3, and 5).

  Normally, in order to extract a region of interest, the controller 38 (see FIG. 5) emphasizes the contour of the scanner image read in step S1, and outputs a contour-enhanced image. As the contour enhancement processing, for example, contour enhancement processing by first-order differentiation for obtaining the difference between the pixel of interest and its surrounding pixels, represented by the Sobel filter processing and Prewitt filter processing, Laplacian filter What is necessary is just to perform the contour emphasis process by the secondary differentiation etc. which calculates | requires the further difference of the difference of an attention pixel and its peripheral pixel represented by the (Laplacian filter) process. Since these contour enhancement processes are known techniques, their description is omitted.

  This contour-enhanced image is used for the extraction result (flow channel region). In other words, the controller 38 (see FIG. 5) applies an algorithm such as contour enhancement processing to the scanner image to emphasize the contour of the scanner image and output the contour enhanced image, whereby the disk 24 (FIG. 1 or FIG. 5). 3) (see FIG. 3 and FIG. 4) U-shaped flow path (see FIG. 1 and FIG. 4) of the flow path contour (that is, the flow path region) and the boundary position of gas / plasma or plasma / blood cells, The outline of the flow path (flow path area) is extracted, and the boundary position and the area surrounded by the flow path area are extracted as component areas. Then, the flow channel region 71 (see FIGS. 8A to 8D) obtained as an extraction result by the algorithm of the contour enhancement process is written and stored in the extraction result memory unit 37B (see FIG. 5). At the same time, the component area 72 (see FIGS. 8A and 8C) may be written and stored in the extraction result memory unit 37B (see FIG. 5).

(Step T1) Image Reading On the other hand, the first reading unit 36A (see FIG. 5) receives the IP acquired by the imaging plate IP (see FIG. 1) via the reading unit 31 (see FIGS. 1 and 2). Load an image. The order of step S1 and step T1 described above is not particularly limited, and step T1 may be performed first, step S1 may be performed first, or steps S1 and T1 may be performed concurrently. Good.

(Step S2) Image Display The scanner image read in step S1 is displayed on each screen of the output monitor 50 (see FIG. 6). At that time, the scanner image may be reduced, and the reduced scanner image may be displayed on the reduction screen 53 shown in FIG. 6 and then enlarged and displayed on the main screen 51 shown in FIG.

(Step S3) Extraction Result Display When the scanner image is displayed on the main screen 51 shown in FIG. 6 in step S2, an algorithm is applied to the scanner image as shown in FIGS. 8 (a) to 8 (d). The flow path area extracted as the extraction result is added to the scanner image and displayed on the main screen 51. In order to add and display the extraction results (flow channel region, component region) shown in FIGS. 8A to 8D on the main screen 51, the extraction results from the extraction result memory unit 37B (see FIG. 5) are displayed. The flow channel region is read out, and the flow channel region 71 is added to the scanner image and displayed on the main screen 51 as shown in FIGS. 8A to 8D. In addition to the channel region 71, as shown in FIGS. 8A and 8C, the component region 72 can be added to the scanner image as an extraction result and displayed on the main screen 51. This step S3 corresponds to the extraction result display step in this invention.

  In FIG. 8A to FIG. 8D, the extraction result (flow channel region 71) is formed by a surrounding region surrounding the flow channel on the scanner image and a filled region that fills the flow channel on the scanner image with a color. ing.

  In addition, in FIG. 8A and FIG. 8C, the component region 72 is also displayed, and the component region 72 is a plasma BP / blood cell BC which is each component obtained by centrifuging blood. Is a surrounding area. In particular, in FIG. 8A, the component region 72 is a combination of a surrounding region and a painted region that fills the plasma BP / blood cell BC. Plasma BP and blood cells BC are separately enclosed and displayed by the enclosed area, and plasma BP and blood cells BC are separately filled and displayed by the filled area.

  After detecting the boundary position of gas / plasma or plasma / blood cells, the flow of the U-shaped flow path 26 (see FIG. 1 or 4) of the disk 24 (see FIG. 1, FIG. 3 or FIG. 4). By detecting the outline of the road, the component area 72 is extracted first, and then the flow path area 71 is extracted. Of course, after detecting the contour in the flow path of the U-shaped flow path 26 of the disc 24, the flow path region 71 is first extracted by detecting the boundary position of gas / plasma or plasma / blood cells, and then The component region 72 may be extracted with If the component region 72 is extracted after extracting the flow channel region 71, whether the flow channel region 71 is correctly detected as shown in FIG. 8B or erroneously detected as shown in FIG. 8D described later. It is possible to easily confirm whether or not

  Further, if the flow channel region is erroneously detected, the plasma flow region can be adjusted and corrected in step S4 to be described later before detecting the boundary position of gas / plasma or plasma / blood cells. It becomes easier to detect the region and the blood cell region more accurately.

  As described above, as a result of the surface scratches, dust, dust, or the like appearing in the scanner image, the extracted component region 72 becomes an actual gas / plasma or plasma / blood cell as shown in FIG. Even if misdetection is caused with a deviation from the boundary position, it can be determined that the misdetection has actually occurred. Similarly, as shown in FIG. 8D, as a result of tilting when taking an image with a flat head scanner, even if the extracted flow path region 71 is misdetected with respect to the actual flow path, an error is detected. It can be determined that detection has actually occurred.

(Step S4) Adjustment Even if there is an erroneous detection in step S3, it is even more preferable to adjust as in step S4. Specifically, at least one of the scanner image and the channel region 71 as the extraction result is adjusted by moving on the display screen, or the size of the channel region 71 as the extraction result is adjusted on the display screen. . It adjusts with the input part 39 (refer FIG. 5). From the output monitor 50 shown in FIG. 6, the flow channel regions 71 (other component regions 72) as the respective extraction results are grouped, and the grouped extraction results are dragged to match the components and flow channels of the scanner image. Do not move and adjust on the display screen or group each extraction result (flow channel region, component region), and drag the extraction results (flow channel region, component region) individually. It is adjusted by moving it on the display screen so as to match the components and flow paths of the image, or by adjusting the pointer to the enclosing part of the enclosing area and adjusting the size of the extraction result (flow path area, component area). Of course, the scanner image may be moved and adjusted on the display screen, or both may be moved and adjusted on the display screen. Further, the input unit 39 is configured by a touch panel of the output monitor 50, and adjustment is performed by directly touching a scanner image or an extraction result (flow path region, component region) to be adjusted on the touch panel of the output monitor 50 with a finger. May be. This step S4 corresponds to the image / extraction result adjustment step in the present invention.

(Step T2) Image Display On the other hand, the IP image read in step T1 is also displayed on each screen of the output monitor 50 (see FIG. 6). At this time, the IP image may be reduced, and the reduced IP image may be displayed on the reduction screen 52 shown in FIG. 6 and then enlarged and displayed on the main screen shown in FIG. The order of steps S2 to S4 and T2 described above is not particularly limited, and step T2 may be performed first, steps S2 to S4 may be performed first, or steps S2 to S4 and T2 are performed in parallel. You may go to

(Step U1) Superimposition Processing The controller 38 (see FIG. 5) performs superimposition processing by superimposing the scanner image adjusted in step S4 and the IP image displayed in step T2.

(Step U2) Superimposition Display The image after superimposition processing (shown as “superimposed image” in FIG. 9) is displayed on each screen of the output monitor 50 (see FIG. 6). At this time, the image after the superimposition process is reduced, and the image after the reduction process is displayed on the reduction screen 54 shown in FIG. 6 and then enlarged and displayed on the main screen shown in FIG. Good.

  According to the display device 35 used in the measurement system according to the present embodiment, an image (scanner image in the present embodiment) obtained by imaging the measurement target is displayed, and the image (scanner image) is extracted with an algorithm. As a result of the extraction, it relates to the flow path (U-shaped flow path 26 in this embodiment) of the container (disk 24 in this embodiment) provided to accommodate the liquid to be measured (blood in this embodiment). The flow channel region 71 is added to the image (scanner image) and displayed, and the flow channel region 71 is surrounded by a surrounding region and an image (scanner image) surrounding the flow channel (U-shaped flow channel 26) on the image (scanner image). An extraction result display that forms the upper flow path (U-shaped flow path 26) with a color-filled area, surrounds the flow path with the enclosed area, and displays the flow path with the filled area. (Main screen 51 in the present embodiment), the flow path region 71 formed by the surrounding region and the painted region as an extraction result extracted by the algorithm is added to the image (scanner image) obtained by actual imaging. By adding and displaying, the channel region 71 as an extraction result is erroneously detected without matching each region of an image (scanner image) obtained by actual imaging due to dust, dirt, scratches, or the like. Even so, it is possible to easily determine at least that there was an erroneous detection based on the surrounding area and the filled area. Further, when the flow path area 71 as the extraction result matches each area of the image (scanner image) obtained by actual imaging, it is easily determined by the surrounding area and the filled area that there is no false detection. can do. As a result, the presence / absence of erroneous detection can be easily determined based on the flow channel region 71 (enclosed region and filled region) as the extraction result extracted by the algorithm.

  It should be noted that the color to be painted as described above is not limited to a colored color, but includes a color painted according to a pixel value of an image (for example, a transparent color or a semi-transparent color).

  Further, according to the display method and the display program 37A according to the present embodiment, in step S3, an image (scanner image in the present embodiment) obtained by imaging the measurement target is displayed, and the image (scanner image) is displayed. As an extraction result extracted by the algorithm, a flow path (a U-shaped flow in this embodiment) of a container (a disk 24 in this embodiment) provided to contain a liquid to be measured (blood in this embodiment) is stored. A flow channel region 71 relating to the channel 26) is displayed in addition to the image (scanner image), and the flow channel region 71 is surrounded by a surrounding region and an image surrounding the flow channel (U-shaped channel 26) on the image (scanner image). The flow path (U-shaped flow path 26) on the (scanner image) is formed by a filled area that is filled with a color, and the flow path is surrounded and displayed by the enclosed area, and the flow path is filled by the filled area. Doing, extraction result and the flow path area 71, it is possible to easily determine the actual match or mismatched to whether the surrounding region and filled area to each area of the image obtained by the imaging (scanner image). As a result, the presence or absence of erroneous detection can be easily determined based on the extraction results (enclosed area and filled area) extracted by the algorithm.

  In the display device 35 according to the present embodiment, at least one of the image (scanner image in the present embodiment) and the flow channel region 71 as the extraction result is adjusted by moving on the display screen, or the flow channel as the extraction result. It is preferable to provide an image / extraction result adjusting means (in the embodiment, the input unit 39) for adjusting the size of the area 71 on the display screen.

  Further, in the display method according to the present embodiment, at least one of the image (scanner image in the present embodiment) and the flow path region 71 as the extraction result is moved on the display screen to be adjusted, or the flow as the extraction result is displayed. It is preferable to include step S4 for adjusting the size of the road area 71 on the display screen. By adjusting on the display screen, it is possible to make the flow channel region 71, which is an extraction result having a false detection, relatively coincide with the image (scanner image), and the flow as the extraction result extracted by the algorithm is used. The display of each area | region of an image (scanner image) can be emphasized with the flow path area | region 71 which adjusted the road area | region 71 manually and made the adjusted extraction result.

  In this embodiment, the extraction result display means (main screen 51 in this embodiment) is obtained by centrifuging the liquid to be measured (blood in this embodiment) on the image (scanner image in this embodiment). It is preferable to add and display the component region 72 (see FIGS. 8A and 8C) as an extraction result for each component (plasma BP / blood cell BC in the present embodiment). Each component (plasma BP, blood cell BC) on the image (scanner image) is displayed by adding the component region 72 extracted by the algorithm to display each component (plasma BP • It is possible to easily determine whether the blood cell BC) matches or does not match the component region 72 extracted by the algorithm.

  An example of the component region 72 (an example of the former) is a surrounding region surrounding each component (plasma BP / blood cell BC in this embodiment) on the image as shown in FIG. (In the present embodiment, the main screen 51) separately displays each component (plasma BP / blood cell BC) by the surrounding area. Alternatively, another example of the component region 72 (an example of the latter) is a painted region that fills each component (plasma BP / blood cell BC) on the image with a color, and the extraction result display means (main screen 51) Each component (plasma BP / blood cell BC) is separately filled and displayed in the filled area. As described in the flow channel region 71, the color to be painted is not limited to a colored color. Further, as shown in FIG. 8 (a), the former example and the latter example are combined, and each component (plasma BP / blood cell BC) is separately enclosed and displayed by the enclosed region, and the inner portion is a filled region. Each component (plasma BP / blood cell BC) may be filled and displayed separately.

  The present invention is not limited to the above-described embodiment, and can be modified as follows.

  (1) In the above-described embodiments, blood has been described as an example of the liquid to be measured. However, the liquid is not limited to blood, and includes a radioactive substance, a luminescent substance, and a fluorescent agent. Or a liquid mixture used in an analyzer. Further, the liquid to be measured need not be the liquid to be centrifuged.

(2) In the above-described embodiment, the measurement information image is an IP image having measurement information of radiation (β ⁺ rays in this embodiment) acquired from the imaging plate IP. If it is a measurement information image having measurement information on the light emitted from the contained luminescent or fluorescent material or the radiation contained in the liquid to be measured, for example, light (photon: photon) or radiation directly It is not necessarily limited to an IP image, such as a measurement information image obtained by counting.

  (3) In the above-described embodiment, the morphological information image is a scanner image acquired from the flat head scanner of the imaging unit 34. However, if the morphological information image has the morphological information of the liquid to be measured, for example, It is not necessarily limited to a scanner image, such as a morphological information image acquired by a radiation imaging means composed of radiation irradiating means and radiation detecting means.

  (4) In the above-described embodiment, the target image to be displayed with the flow channel region added as the extraction result is a morphological information image (scanner image in the embodiment) having the morphological information of the liquid to be measured. However, it is not limited to this. For example, it may be a measurement information image (IP image in the embodiment) having light or radiation measurement information.

  (5) In the above-described embodiment, the algorithm for outputting the flow channel region as the extraction result is the contour emphasis processing. However, the algorithm is not limited to the contour emphasis processing as long as the algorithm is normally used.

  (6) In the above-described embodiment, at least one of an image (scanner image in the embodiment) and a flow path region that is an extraction result is adjusted by moving on the display screen, or the size of the flow path area that is the extraction result. The height is adjusted on the display screen. However, when the positions of the image and the flow path region as the extraction result are relatively coincident with each other, the adjustment is not necessarily required.

  (7) In the above-described embodiment, the container is a disk that performs centrifugation. However, if the liquid to be measured is not the liquid to be centrifuged, the container is a circle that stores the liquid. It is not limited to a board. It may be a square plate or a polygonal plate.

  (8) In the embodiment described above, a plurality of U-shaped flow paths 26 formed in the radial direction are provided by radially grooving along the radial direction of the disk 24, but are not necessarily arranged radially. do not have to. For example, you may arrange | position in parallel mutually.

  (9) When the centrifugal separation is not performed as in the above-described modification (1) and modification (7), only the flow channel region may be obtained as the extraction result. In that case, for the color to be filled, the entire region (flow channel region) of a single component that is not separated may be displayed in a single color.

  (10) In the embodiment described above, the components are two components (plasma and blood cells in the embodiment), and each component is separately displayed by color, but in the case of three or more components, Three or more components may be painted separately. Moreover, even if it is two components, you may paint also about the location of gas. Further, it may be only the enclosed area without being painted.

  (11) In the above-described embodiment, the fixing jig 61 that supports the container (the disk 24 in the embodiment) while fixing and positioning is provided, but the fixing jig 61 is not necessarily provided. For example, as shown in FIG. 4, by providing a recess in the disk 24 itself, or by providing a notch or protrusion on the disk 24 itself, the object is to be superimposed on the basis of the recess, notch or protrusion. The image orientation may be aligned. Alternatively, a superimposing process may be performed by pasting a member having different light or radiation transmissivity as a marker on a predetermined portion of the disc 24 and aligning the direction of the captured image with the marker portion as a reference.

  (12) In the above-described embodiment, the automatic blood collection by the blood collection device 10 is described as an example in the measurement system, but the liquid collection method is not limited to the automatic liquid collection device. The liquid may be dropped onto the U-shaped flow path 26 of the disk 24 by an operator's technique.

24 ... disk 26 ... U-shaped flow path 35 ... display device 37A ... display program 38 ... controller 39 ... input unit 51 ... main screen 71 ... flow path area 72 ... component area BP ... plasma BC ... blood cell

Claims (6)

A display device used in a measurement system that measures light generated from luminescent or fluorescent substances contained in a liquid to be measured or radiation contained in the liquid to be measured,
Displaying an image obtained by imaging the measurement object on a display screen ;
Based on an image obtained by imaging with respect to the measurement target, the flow path region related to the flow path of the container provided to contain the liquid to be measured is extracted with an algorithm,
Based on the extraction result, the flow channel region is formed by the surrounding region surrounding the flow channel on the image obtained by the imaging and the filled region to be filled with color, and the image is added to the image obtained by the imaging and displayed. Extraction result display means;
At least one of the image obtained by the imaging and the flow channel region is manually moved on the display screen, and the relative position on the displayed display screen is adjusted, or the image obtained by the imaging A display device comprising: an image / extraction result adjusting unit that manually adjusts the size of the flow channel region on the display screen . The display device according to claim 1,
The extraction result display means displays a component area added as the extraction result to each component obtained by centrifuging the liquid to be measured on the image. . The display device according to claim 2,
The component region is a surrounding region surrounding each component on the image,
The extraction result display means displays the components separately in the enclosed area. The display device according to claim 2 or claim 3,
The component area is a filled area that fills each component on the image with a color,
The extraction result display means displays the respective components separately by using the filled area. A display method for displaying measurement data obtained by measuring light emitted from a luminescent or fluorescent substance contained in a liquid to be measured or radiation contained in the liquid to be measured,
Displaying an image obtained by imaging the measurement object on a display screen ;
Based on an image obtained by imaging with respect to the measurement target, the flow path region related to the flow path of the container provided to contain the liquid to be measured is extracted with an algorithm,
Based on the extraction result, the flow channel region is formed by the surrounding region surrounding the flow channel on the image obtained by the imaging and the filled region to be filled with color, and the image is added to the image obtained by the imaging and displayed. Extraction result display process;
At least one of the image obtained by the imaging and the flow channel region is manually moved on the display screen, and the relative position on the displayed display screen is adjusted, or the image obtained by the imaging A display method comprising: an image / extraction result adjustment step of manually adjusting a size of the flow channel region with respect to the display screen . Causes a computer to execute a series of processing for displaying measurement data obtained by measuring light emitted from a luminescent or fluorescent substance contained in the liquid to be measured or radiation contained in the liquid to be measured. Display program for
Displaying an image obtained by imaging the measurement object on a display screen ;
Based on an image obtained by imaging with respect to the measurement target, the flow path region related to the flow path of the container provided to contain the liquid to be measured is extracted with an algorithm,
Based on the extraction result, the flow channel region is formed by the surrounding region surrounding the flow channel on the image obtained by the imaging and the filled region to be filled with color, and the image is added to the image obtained by the imaging and displayed. Extraction result display process;
At least one of the image obtained by the imaging and the flow channel region is manually moved on the display screen, and the relative position on the displayed display screen is adjusted, or the image obtained by the imaging An image / extraction result adjustment step of manually adjusting the size of the flow channel region with respect to the display screen .

Images