JP6062793B2 - 血流画像診断装置 - Google Patents
血流画像診断装置 Download PDFInfo
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- JP6062793B2 JP6062793B2 JP2013090562A JP2013090562A JP6062793B2 JP 6062793 B2 JP6062793 B2 JP 6062793B2 JP 2013090562 A JP2013090562 A JP 2013090562A JP 2013090562 A JP2013090562 A JP 2013090562A JP 6062793 B2 JP6062793 B2 JP 6062793B2
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7271—Specific aspects of physiological measurement analysis
- A61B5/7282—Event detection, e.g. detecting unique waveforms indicative of a medical condition
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/026—Measuring blood flow
- A61B5/0261—Measuring blood flow using optical means, e.g. infrared light
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/0016—Operational features thereof
- A61B3/0025—Operational features thereof characterised by electronic signal processing, e.g. eye models
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/12—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
- A61B3/1225—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes using coherent radiation
- A61B3/1233—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes using coherent radiation for measuring blood flow, e.g. at the retina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/12—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
- A61B3/1241—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes specially adapted for observation of ocular blood flow, e.g. by fluorescein angiography
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/74—Details of notification to user or communication with user or patient ; user input means
- A61B5/742—Details of notification to user or communication with user or patient ; user input means using visual displays
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T5/00—Image enhancement or restoration
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T7/00—Image analysis
- G06T7/0002—Inspection of images, e.g. flaw detection
- G06T7/0012—Biomedical image inspection
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T2207/00—Indexing scheme for image analysis or image enhancement
- G06T2207/10—Image acquisition modality
- G06T2207/10024—Color image
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T2207/00—Indexing scheme for image analysis or image enhancement
- G06T2207/30—Subject of image; Context of image processing
- G06T2207/30004—Biomedical image processing
- G06T2207/30088—Skin; Dermal
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T2207/00—Indexing scheme for image analysis or image enhancement
- G06T2207/30—Subject of image; Context of image processing
- G06T2207/30004—Biomedical image processing
- G06T2207/30101—Blood vessel; Artery; Vein; Vascular
- G06T2207/30104—Vascular flow; Blood flow; Perfusion
Description
MBR = (スペックルのコントラスト)-2 = (平均光強度 / 変動成分の標準偏差)2
で定義される。白色人種に比べて有色人種の方が網膜血管のMBR値が低く表示される理由は以下のように説明できる。有色人種の血管部の血流成分によるスペックルの時間変化は白色人種と変わらないが、背景組織に含まれる色素成分によって後方散乱光が低下し、上式の分子にある平均光強度が白人より低下する。その結果血流値(MBR値)が低めに表示される。
Claims (7)
- 血球を有する生体組織の観察領域にレーザー光を照射するレーザー光照射系と、前記生体組織の観察領域からの反射光を検出する複数の画素からなる受光部と、前記受光部からの信号に基づき連続的に複数の画像を取り込む画像取込部と、前記複数の画像を記憶する画像記憶部と、該記憶された複数画像の対応する各画素の出力信号の時間的変化から生体組織内の血流速度を演算する演算部と、該演算結果の二次元分布を血流マップとして表示する表示部からなる血流画像診断装置において、
前記演算部における演算により得られた血流マップに観察領域の色素濃度に応じた補正を加えるための色素濃度補正部を備えたことを特徴とする血流画像診断装置。 - 前記色素濃度補正部は、観察領域の色素濃度をレーザー反射率として検出するレーザー反射率演算部と、該レーザー反射率演算部からのレーザー反射率に基づいて、血流マップを補正する補正係数を作成する補正係数作成部を備えた請求項1に記載の血流画像診断装置。
- 前記演算部は、血流マップのずれ量を計算し、移動量を補正して重ねるトラッキング処理を行う血流解析部と、トラッキング処理された血流マップに対して、色素濃度補正部から出力された補正係数に基づき観察領域の色素濃度に応じた補正を加える血流マップ作成部を備え、前記レーザー反射率演算部は、血流マップを合成する基になるスペックル画像を重ね合わせて得られるレーザー反射強度マップから求めたレーザー反射強度及びレーザー光照射系から照射されるレーザー光の強度信号を基に、レーザー反射率を求める請求項2に記載の血流画像診断装置。
- 観察領域におけるレーザー反射率と血流値の関係を複数の健常者に対して予め求めてその関係を記憶する記憶部を備え、前記補正係数作成部は、新たに測定された血流マップに関して取得したレーザー反射率に基づいて、前記記憶部に記憶しているレーザー反射率と血流値の関係から前記補正係数を作成する請求項3に記載の血流画像診断装置。
- 前記レーザー反射率は観察領域毎に算出され、かつ各観察領域に対して別々の補正係数を作成する請求項4に記載の血流画像診断装置。
- 前記生体組織の血流は、眼底血流、或いは皮膚血流である請求項1に記載の血流画像診断装置。
- 前記観察領域は皮膚組織であり、この皮膚組織の色素濃度に応じた前記補正は、比較的安定な数値になることが解っている特定の部位を対象として一段目の補正として行い、かつ、色素の濃さ及び角質層の散乱特性の異なる部位別の補正係数を前記一段目の補正に掛ける二段目の補正を行う請求項1に記載の血流画像診断装置。
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2013090562A JP6062793B2 (ja) | 2013-04-23 | 2013-04-23 | 血流画像診断装置 |
CA2871400A CA2871400C (en) | 2013-04-23 | 2014-04-17 | Blood flow image diagnosing device and method |
EP14780741.6A EP2989977A4 (en) | 2013-04-23 | 2014-04-17 | IMAGING DEVICE FOR BLOOD FLOW DIAGNOSIS AND DIAGNOSTIC METHOD |
PCT/JP2014/060909 WO2014175154A1 (ja) | 2013-04-23 | 2014-04-17 | 血流画像診断装置及び診断方法 |
US14/391,539 US10098592B2 (en) | 2013-04-23 | 2014-04-17 | Blood flow image diagnosing device and method |
Applications Claiming Priority (1)
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---|---|---|---|
JP2013090562A JP6062793B2 (ja) | 2013-04-23 | 2013-04-23 | 血流画像診断装置 |
Publications (2)
Publication Number | Publication Date |
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JP2014212851A JP2014212851A (ja) | 2014-11-17 |
JP6062793B2 true JP6062793B2 (ja) | 2017-01-18 |
Family
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JP2013090562A Active JP6062793B2 (ja) | 2013-04-23 | 2013-04-23 | 血流画像診断装置 |
Country Status (5)
Country | Link |
---|---|
US (1) | US10098592B2 (ja) |
EP (1) | EP2989977A4 (ja) |
JP (1) | JP6062793B2 (ja) |
CA (1) | CA2871400C (ja) |
WO (1) | WO2014175154A1 (ja) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
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JP6062793B2 (ja) * | 2013-04-23 | 2017-01-18 | ソフトケア有限会社 | 血流画像診断装置 |
US10178959B1 (en) * | 2014-07-10 | 2019-01-15 | Verily Life Sciences Llc | Non-invasive flow monitoring |
KR102299361B1 (ko) * | 2014-09-03 | 2021-09-07 | 삼성전자주식회사 | 혈압을 모니터링하는 장치 및 방법, 혈압 모니터링 기능을 갖는 웨어러블 디바이스 |
EP3188651A4 (en) | 2014-10-14 | 2018-07-04 | East Carolina University | Methods, systems and computer program products for visualizing anatomical structures and blood flow and perfusion physiology using imaging techniques |
WO2016061041A1 (en) * | 2014-10-14 | 2016-04-21 | East Carolina University | Methods, systems and computer program products for determining hemodynamic status parameters using signals derived from multispectral blood flow and perfusion imaging |
US11553844B2 (en) * | 2014-10-14 | 2023-01-17 | East Carolina University | Methods, systems and computer program products for calculating MetaKG signals for regions having multiple sets of optical characteristics |
US10219687B2 (en) | 2014-11-07 | 2019-03-05 | Ohio State Innovation Foundation | Methods and apparatus for making a determination about an eye in ambient lighting conditions |
JP6507639B2 (ja) * | 2014-12-29 | 2019-05-08 | 花王株式会社 | 皮膚血流量の計測方法 |
KR102411658B1 (ko) | 2015-01-15 | 2022-06-21 | 삼성전자주식회사 | 생체 정보 검출 장치 |
KR102384225B1 (ko) | 2015-03-06 | 2022-04-07 | 삼성전자주식회사 | 혈압 측정 장치 및 방법 |
IL239113A (en) | 2015-06-01 | 2016-12-29 | Elbit Systems Land & C4I Ltd | A system and method for determining audio characteristics from a body |
KR101788850B1 (ko) * | 2015-08-24 | 2017-10-20 | 상명대학교산학협력단 | 영상 피부색 증폭을 통한 심박 신호 측정 방법 |
KR102434701B1 (ko) | 2015-09-01 | 2022-08-22 | 삼성전자주식회사 | 생체 정보 획득 장치 및 생체 정보 획득 방법과 생체 정보 검사 장치 |
US11330995B2 (en) | 2016-06-28 | 2022-05-17 | Softcare Co., Ltd. | Apparatus and method for imaging and analyzing hemodynamics |
KR102655671B1 (ko) | 2016-10-12 | 2024-04-05 | 삼성전자주식회사 | 생체정보 추정 장치 및 방법 |
JP6489707B2 (ja) * | 2016-12-22 | 2019-03-27 | 義則 宮▲崎▼ | 緑内障のリスクレベルの判定補助方法、緑内障のリスクレベルを判定するための判定装置および判定プログラム |
JP7266293B2 (ja) * | 2019-07-18 | 2023-04-28 | ソフトケア有限会社 | スペックル信号調整装置、並びにこれを使用した画像化測定装置の校正方法および画像化測定装置の異常診断方法 |
US11622682B2 (en) | 2019-12-27 | 2023-04-11 | Ohio State Innovation Foundation | Methods and apparatus for making a determination about an eye using color temperature adjusted ambient lighting |
US20210196119A1 (en) | 2019-12-27 | 2021-07-01 | Ohio State Innovation Foundation | Methods and apparatus for detecting a presence and severity of a cataract in ambient lighting |
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JP6062793B2 (ja) * | 2013-04-23 | 2017-01-18 | ソフトケア有限会社 | 血流画像診断装置 |
-
2013
- 2013-04-23 JP JP2013090562A patent/JP6062793B2/ja active Active
-
2014
- 2014-04-17 WO PCT/JP2014/060909 patent/WO2014175154A1/ja active Application Filing
- 2014-04-17 US US14/391,539 patent/US10098592B2/en active Active
- 2014-04-17 CA CA2871400A patent/CA2871400C/en active Active
- 2014-04-17 EP EP14780741.6A patent/EP2989977A4/en not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
US20160278718A1 (en) | 2016-09-29 |
WO2014175154A1 (ja) | 2014-10-30 |
EP2989977A1 (en) | 2016-03-02 |
JP2014212851A (ja) | 2014-11-17 |
EP2989977A4 (en) | 2016-06-01 |
CA2871400A1 (en) | 2014-10-30 |
CA2871400C (en) | 2019-06-18 |
US10098592B2 (en) | 2018-10-16 |
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