JP5943342B2 - 概日リズム改善剤 - Google Patents
概日リズム改善剤 Download PDFInfo
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- JP5943342B2 JP5943342B2 JP2012046806A JP2012046806A JP5943342B2 JP 5943342 B2 JP5943342 B2 JP 5943342B2 JP 2012046806 A JP2012046806 A JP 2012046806A JP 2012046806 A JP2012046806 A JP 2012046806A JP 5943342 B2 JP5943342 B2 JP 5943342B2
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- circadian rhythm
- improving agent
- lactic acid
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
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- A—HUMAN NECESSITIES
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- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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Description
ストレス性睡眠障害を誘発したマウスを用い、マウスの自発行動量(輪回し行動量。以下「活動量」ともいう。)を指標としてSBL88株の菌体処理物による概日リズムの改善効果を評価した。
SBL88株を培地(組成:マルトース2質量%、酵母エキス1.4質量%、酢酸ナトリウム0.5質量%、硫酸マンガン0.005質量%、pH6.5〜7.0)に植菌し、30℃で1日間静置培養した。得られた培養液(約8×108cfu/ml)を8,000rpmで10分間遠心分離し、菌体を回収した。回収した菌体を蒸留水に再懸濁し、8,000rpmで10分遠心分離し、菌体を回収した。この操作を2度繰り返した。回収した菌体を蒸留水に懸濁し、105℃で10分間加熱処理した後、凍結乾燥して加熱処理菌体粉末(菌体処理物)を得た。
粉末飼料CE−2(日本クレア株式会社製)にSBL88株の菌体処理物を0.5質量%添加した後、ペレット化して菌体処理物を含むマウス飼料(SBL88含有CE−2飼料)を調製した。対照として、粉末飼料CE−2をペレット化して菌体処理物を含まないマウス飼料(CE−2飼料)を調製した。
全期間を通して、マウスを回転かご(SW−15S、有限会社メルクエスト)内で飼育した。マウスの活動量は、クロノバイオロジーキット(Stanford Software Systems,CA)を用いて測定した。
非ストレス飼育期間後、物理的に遮蔽してマウスが回転輪から降りられないように制限することにより、ストレス性睡眠障害を2週間連続的に誘発した(ストレス飼育期間)。このストレス性睡眠障害マウスは、一般的な睡眠障害に外挿できるリズム障害を示す。また、総活動量がやや低下するとともに、明期暗期ともに活動が見られる行動リズムの乱れが観察される。特に明期前半の過活動が特徴である。またこれに連動するように、明期前半の睡眠量低下、活動期(暗期)における睡眠量の増加が認められる。
図1は、マウスの1日の行動パターンを示す図である。図1中、縦軸は飼育期間を表し、非ストレス飼育期間の開始日を0週間(0w)、馴化飼育期間の開始日をマイナス2週間(−2w)で表す。横軸は時刻を表す。ドットはマウスの輪回し行動が観察されたことを示す。なお、図1(A)はストレス負荷していないマウスの行動パターンを、図1(B)はストレス負荷したマウスの行動パターン(非ストレス飼育期間4w経過時点からストレス負荷開始)を示す。図1より、明期(8〜20時:睡眠時間帯)では、ほとんど輪回し行動が観察されないことが分かる(ドットが少ない)。一方、暗期(20〜8時:活動時間帯)では、活発に輪回し行動を行っていることが分かる(ドットが多い)。また、マウスに上記ストレスを与えることで、明期におけるドットの増加及び暗期におけるドットの減少が観察され、行動パターンが乱れることが分かる。
ストレス飼育期間における暗期(20〜8時:活動時間帯)と明期(8〜20時:睡眠時間帯)とで、対照群とSBL88群の1日あたりの活動量を比較した。図2は、暗期における1日あたりの活動量を示すグラフである。図3は明期における1日あたりの活動量を示すグラフである。図2及び図3において、ストレス飼育期間(2週間)の最初の1週間を前期とし、残りの1週間を後期とした。
実施例1における、ストレス負荷最終日(2週間負荷後)の午前8〜10に殺処分したマウスの大腸から全mRNAを抽出した後、定量PCR法にて時計遺伝子(Per1、Per2、BMAL1)の発現量を調べた。
Claims (10)
- 乳酸菌の菌体又はその処理物を有効成分として含有する概日リズム改善剤(但し、発酵ホエーを含有するものを除く。)。
- 前記乳酸菌が、ラクトバチラス・ブレビス(Lactobacillus brevis)に属する乳酸菌である、請求項1に記載の概日リズム改善剤。
- 前記乳酸菌が、ラクトバチラス・ブレビス(Lactobacillus brevis)SBC8803(受託番号:FERM BP−10632)である、請求項1又は2に記載の概日リズム改善剤。
- 時計遺伝子のmRNA発現量を正常化させることに基づくものである、請求項1〜3のいずれか一項に記載の概日リズム改善剤。
- 前記時計遺伝子が、Per2又はBmal1である、請求項4に記載の概日リズム改善剤。
- 概日リズム睡眠障害改善用である、請求項1〜5のいずれか一項に記載の概日リズム改善剤。
- 請求項1〜6のいずれか一項に記載の概日リズム改善剤の概日リズム改善用飲食品の製造における使用。
- 請求項1〜6のいずれか一項に記載の概日リズム改善剤を含有する概日リズム改善用医薬品。
- 請求項1〜6のいずれか一項に記載の概日リズム改善剤を含有する概日リズム改善用飲食品。
- 請求項1〜6のいずれか一項に記載の概日リズム改善剤を含有する概日リズム改善用飲食品添加物。
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JP2012046806A JP5943342B2 (ja) | 2012-03-02 | 2012-03-02 | 概日リズム改善剤 |
CA2865874A CA2865874C (en) | 2012-03-02 | 2013-02-08 | Circadian rhythm-improving agent |
US14/382,193 US10695383B2 (en) | 2012-03-02 | 2013-02-08 | Circadian rhythm-improving agent |
PCT/JP2013/053091 WO2013129085A1 (ja) | 2012-03-02 | 2013-02-08 | 概日リズム改善剤 |
EP13754034.0A EP2821073B1 (en) | 2012-03-02 | 2013-02-08 | Agent for use in improving circadian rhythm sleep disorders |
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EP (1) | EP2821073B1 (ja) |
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TWI731377B (zh) | 2019-07-25 | 2021-06-21 | 生展生物科技股份有限公司 | 短乳酸桿菌ProGA28及其代謝物用於治療或改善睡眠障礙之用途 |
WO2021131568A1 (ja) * | 2019-12-25 | 2021-07-01 | サントリーホールディングス株式会社 | 身体活動量低下の抑制又は改善用組成物 |
JP2022088787A (ja) * | 2020-12-03 | 2022-06-15 | 日清食品ホールディングス株式会社 | 時計遺伝子の発現を制御するビフィズス菌 |
CN115590889A (zh) * | 2022-10-11 | 2023-01-13 | 江南大学(Cn) | 一种调节生物昼夜节律的短双歧杆菌及其应用 |
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US20070207134A1 (en) | 2004-03-31 | 2007-09-06 | Calpis Co., Ltd | Functional food for ameliorating engogenous melatonin secretion rhythm and functional food for ameliorating circadian rhythm |
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WO2021157434A1 (ja) | 2020-02-05 | 2021-08-12 | 雪印メグミルク株式会社 | 睡眠促進用組成物及び組成物を含む食品、医薬品、飼料 |
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US10695383B2 (en) | 2020-06-30 |
US20150064151A1 (en) | 2015-03-05 |
CA2865874A1 (en) | 2013-09-06 |
EP2821073A4 (en) | 2016-01-27 |
CA2865874C (en) | 2020-06-09 |
EP2821073B1 (en) | 2019-11-06 |
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WO2013129085A1 (ja) | 2013-09-06 |
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