JP5684490B2 - Syringe assembly, method for forming a syringe assembly, and adapter for forming a syringe assembly - Google Patents

Description

  The present invention relates to a syringe assembly, a method of forming a syringe assembly, and an adapter for forming a syringe assembly.

BACKGROUND OF THE INVENTION The following information is provided to help readers understand the invention disclosed below and the environment in which it is commonly used. The terms used herein are not intended to be limited to a particular narrow interpretation unless explicitly stated in this document. The symbols set forth herein facilitate understanding of the invention and the background of the invention. The disclosures of all references cited herein are hereby incorporated by reference.

Injector-driven syringes and powered injectors are used for, but not limited to, therapeutic drug delivery and diagnostic drug delivery (eg, angiography, computed tomography, ultrasound, NMR / MRI, etc.).
U.S. Pat. No. 4,006,736 shows, for example, an injector and syringe that injects fluid into the human or animal vasculature. Generally, such injectors include a drive member such as a piston that is connected to and moves the syringe plunger. For example, U.S. Pat.No. 4,677,980 discloses an angiographic injector and syringe, where the injector drive member is connected to the syringe plunger at any point along the plunger's transition path by a releasable mechanism and out of the syringe plunger. The disclosure of which is incorporated herein by reference. A front loading syringe and injector system is also disclosed in US Pat. No. 5,383,858, the disclosure of which is incorporated herein by reference.

  Various types of syringe interfaces are deployed on the injector to operably connect the syringe to the injector. The front loading injector of US Pat. No. 5,383,858 includes a bayonet syringe interface or attachment mechanism for attaching a syringe to the front wall of the injector. In this regard, the syringe of US Pat. No. 5,383,858 includes two generally opposing mounting flanges at the rear end of the syringe that cooperate with corresponding retaining flanges on the injector to provide bayonet. Form a connection.

U.S. Pat.No. 5,873,861 discloses another front-loading bayonet type syringe mounting mechanism in which multiple pairs or sets of syringe mounting flanges cooperate with corresponding pairs of injector holding flanges to place the syringe on the injector. Attach to. In one embodiment, the first mounting flange pair is spaced from the second mounting flange pair. Another type of attachment mechanism for a front loading syringe is disclosed in US Pat. No. 6,652,489, the disclosure of which is incorporated herein by reference.
In one embodiment of US Pat. No. 6,652,489, the syringe includes a single engaging flange that extends around the entire circumference of the syringe, releasably engages a flexible ring in the syringe interface of the injector, Attach to the injector.

In general, the use of a specially designed or unique mounting mechanism or fixture on the front loading injector prevents the use of various other types of syringes in the flint loading injector (i.e., having a mounting mechanism). The syringe is not directly compatible with the front loading injector or the syringe interface / holding mechanism of the syringe without such an attachment mechanism).
Furthermore, syringes designed for manual injection procedures cannot be directly connected to the injector. Adapters that can be attached to front loading injectors are often used to provide different types of syringes for front loading injectors (e.g., syringes designed for use with other injectors and / or syringes designed for manual injection) Allow) to be used.

For example, US Pat. No. 5,520,653 discloses several adapters designed to allow the use of various syringes for front loading injectors.
Other adapters include PCT Publication No. WO01 / 08727, and U.S. Patent Nos. 6,336,913, 6,488,661, 6,676,634, 6,716,195, 6,726,657, 6,743,205, 7,029,458, 7,273,477. No. 7,497,843, the disclosures of which are incorporated herein by reference.

Generally, such an adapter includes an injector interface that installs the adapter in operative connection with the injector. The injector interface is designed to include an attachment mechanism that is similar to or similar to an attachment mechanism for a syringe that is generally designed to be used in connection with an injector.
The adapter further includes a syringe interface that connects the syringe to the adapter, which is not designed to be directly connected to the injector.
A plunger adapter, or plunger extension, can also be deployed so that the injector piston can be operatively connected to the syringe. Currently available adapters are generally designed to be connected to an injector and modify the syringe interface of the injector. Such adapters are often referred to as “syringe adapters”, but they are more precisely defined as “injector adapters” or “injector interface adapters”.
Once such an adapter is in place on the injector, any number of syringes can be used with it (continuously).

 Although many syringe interfaces and adapters are currently available, it remains desirable to develop improved syringe assemblies and syringe interfaces and adapters that are used with various types of syringe assemblies.

SUMMARY OF THE INVENTION In one aspect of the invention, a syringe assembly is provided that includes a syringe interface and a drive member that can be connected to an injector. The syringe assembly includes a syringe portion including a barrel portion containing a fluid to be pressurized and an outlet connected to the barrel portion so that the fluid can come and go. The syringe assembly also includes an adapter formed separately from the syringe portion and including a plurality of portions. At least two portions of the plurality of portions can irremovably engage the adapter with the syringe portion. In many embodiments, the adapter includes only two portions to irremovably connect the adapter to the syringe portion. The adapter further includes an attachment mechanism configured to be connected to the injector syringe interface. The adapter also includes a passage operatively connected to the barrel portion after the adapter is connected to the syringe portion, and the drive member is slidably positioned through the passage and into the barrel portion when the adapter is connected to the syringe portion. Actuate the plunger to obtain.

  For example, the syringe part includes a flange near the rear end of the syringe part. At least two portions are engageable and the flange is engaged so that it cannot be moved by the adapter.

  For example, at least two parts can be attached via a mechanical connection. In some embodiments, at least two portions can be attached via a snap fit. For example, a snap fit is a permanent snap fit.

  At least two parts are brought together and attached at a non-zero angle with respect to the long axis of the barrel. In many embodiments, at least two parts are brought together and mounted at an angle substantially parallel to the long axis of the barrel portion.

  Each of the at least two portions is formed from a polymeric material. For example, each of the at least two parts is formed separately from the other of the two parts via a molding process.

  In some embodiments, the flange of the syringe portion is non-annular and at least two portions engage the flange so that the syringe portion cannot rotate relative to the adapter.

  For example, one of the at least two portions includes a rear portion that includes an attachment mechanism and a front portion that engages the other of the at least two portions.

  In many embodiments, the adapter further includes at least a third portion engageable with the at least two portions to help prevent disconnection of the connection (eg, snap fit) between the at least two portions. .

In another aspect, a method is provided for forming a syringe assembly connectable to a first injector including a first syringe interface and a first drive member, the method comprising:
A step of providing a barrel portion containing a fluid to be pressurized, a syringe portion having an outlet through which fluid is removably connected to the barrel portion, and an adapter comprising a plurality of parts formed separately from the syringe portion Providing a mounting mechanism configured to be connected to the injector syringe interface; and engaging at least two portions of the plurality of portions to connect the adapter to the syringe portion so as not to move. Including.
The adapter further includes a passage operatively connected to the barrel portion after engagement, and when the adapter is connected to the syringe portion, the first drive member passes through the passage and the plunger slidably moves within the barrel portion. For example, the syringe portion includes an attachment mechanism configured to be connected to a second injector that includes a second syringe interface separate from the first syringe interface of the first injector.
For example, the at least two parts engage with at least a part of the attachment mechanism of the syringe part to connect the adapter to the syringe part so as not to move.

In a further aspect, a syringe portion having a barrel portion containing a fluid to be pressurized and an outlet connected to the barrel portion so that the fluid can flow back and forth is operable on an injector including a syringe interface and a drive member. A kit is deployed that allows it to be connected. The kit includes an adapter that includes a plurality of parts.
At least two portions of the plurality of portions are engageable and connect the adapter to the syringe portion so as not to move. The adapter further includes an attachment mechanism configured to be connected to the injector syringe interface. The adapter also includes a passage operatively connected to the barrel portion after connection of the adapter to the syringe portion, and upon connection to the syringe portion of the adapter, the drive member is slidably disposed within the barrel portion through the passage. Move the plunger to get.

In another aspect, a method for forming a syringe assembly connectable to an injector including a syringe interface and a drive member is provided. The syringe assembly includes a syringe portion having a barrel portion containing a fluid to be pressurized and an outlet connected to the barrel portion so that fluid can flow back and forth.
The method includes a kit including an adapter that includes a plurality of portions that are engageable with at least two portions to connect the adapter to the syringe portion, and an attachment mechanism configured to be connected to an injector syringe interface. A step of deploying. The adapter further includes a passage operatively connected to the barrel portion after the adapter is connected to the syringe portion, and the drive member is slidably positioned through the passage and into the barrel portion when the adapter is attached to the syringe portion. Actuate the plunger to obtain.

In a further aspect, a method is provided for forming a plurality of syringe assemblies connectable to a plurality of injectors. Each of the plurality of syringe assemblies includes a separate unique attachment mechanism configured to connect to a unique cooperating syringe interface on one of the plurality of injectors.
The method comprises the steps of deploying a plurality of barrel portions each containing a fluid to be pressurized and an outlet connected to the barrel portion so that fluid can flow back and forth, each with a plurality of portions and a unique attachment Deploying a plurality of adapters having one of the mechanisms and formed separately from the plurality of syringe sections, engaging at least two portions of each of the plurality of portions of the plurality of injector interfaces, Connecting each of the adapters to one of the plurality of syringe sections so as not to move.
At least two of the plurality of syringe parts are, for example, substantially the same (or have the same shape and dimensions).

  The invention, its nature and attendant advantages will be best appreciated and understood by the following detailed description in conjunction with the accompanying drawings.

FIG. 2 is a side cross-sectional view of a syringe interface of an injector with a syringe, where the syringe is used for an injector (often referred to herein as a “conventional” syringe or, in particular, a “syringe section”) that operably connects to the syringe interface Designed to be

It is side surface sectional drawing to which the syringe sensing system of the syringe interface of FIG. 1A was expanded.

1B is another side cross-sectional view of the syringe interface of FIG. 1A showing the injector piston or drive member operably connected to the plunger of a conventional syringe. FIG.

1B is a perspective view of a conventional syringe designed for use with the syringe interface of FIG. 1A. FIG.

FIG. 4 is a side perspective view of an embodiment of the syringe adapter of the present invention, operatively connected to a syringe portion that is not disassembled or connected and is not designed to be directly connected to a syringe interface of an injector Is in a position to be installed.

2B is a perspective cross-sectional view of the syringe adapter of FIG. 2A operatively connected to a syringe section. FIG.

FIG. 2B is another perspective cross-sectional view of the syringe adapter of FIG. 2A operatively connected to the syringe section.

FIG. 2B is a perspective view of the syringe adapter of FIG. 2A operatively connected to the syringe section.

It is front sectional drawing of the syringe adapter of FIG. 2A.

It is side surface sectional drawing of the syringe adapter of FIG. 2A.

FIG. 2B is a perspective view of a syringe adapter whose operation is similar to the syringe adapter of FIG. 2A, with the syringe portion configured for use with one of two different types of syringe interfaces of different injectors.

FIG. 7 is a perspective view showing the use of the syringe adapter of the present invention for an empty or general syringe or syringe section, and produces a syringe assembly for use with an injector.

FIG. 4 is a perspective view showing the use of another syringe adapter of the present invention for an empty or generic syringe or syringe section, and produces a syringe assembly for use with various injectors.

2H is a perspective view of another syringe portion in an amount substantially different from the syringe of FIGS. 2H and 2I used for one of the syringe adapters of FIG. 2H or FIG. 2I.

For empty or generic syringes or syringe sections, the use of other syringe adapters of the present invention is shown, with a generally annular rear flange to make a syringe assembly for use with an injector.

It is a side perspective view of other examples of the syringe adapter of the present invention, in a state where it is disassembled or not connected, and is operably connected to a new syringe or syringe part. is there.

FIG. 3B is a side cross-sectional view of the syringe adapter of FIG. 3A operatively connected to the syringe section.

3B is a cross-sectional perspective view of a syringe adapter whose operation approximates that of the syringe adapter of FIG. 3A, and is operatively connected to the syringe section.

FIG. 3C is a perspective view of the syringe adapter of FIG. 3C, in a disassembled or unconnected state, aligned in a straight line to operably connect to the syringe section.

3D is a perspective view of the syringe adapter of FIG. 3C operably connected to the syringe section. FIG.

FIG. 3C is a perspective view of the syringe adapter of FIG. 3C operatively connected to a syringe, with other portions engaging the syringe adapter to help maintain the syringe adapter engaged with the syringe portion.

FIG. 4 is a perspective view of another embodiment of the syringe adapter of the present invention, operating in a manner similar to the syringe adapter of FIG. 3C, but including a pressure jacket.

3C shows a cross-sectional view of the syringe adapter of FIG. 3F.

FIG. 6 is a side view of another embodiment of the syringe adapter of the present invention, in a disassembled or unconnected state, in a position to operably connect to a new syringe or syringe section.

FIG. 4B is a perspective view of the syringe adapter of FIG. 4A operatively connected to the syringe section.

FIG. 4B is a side cross-sectional view of the syringe adapter of FIG. 4A operatively connected to the syringe section.

As used in the detailed description of the invention and the appended claims, the singular forms “a”, “an” and “the” include plural forms unless the content clearly dictates otherwise. Contains citations.
Thus, for example, reference to “a flange” includes a plurality of such flanges and their equivalents known to those skilled in the art, and the reference to “the flange” includes one or more Including such flanges and their equivalents known to those skilled in the art.

  As noted above, currently available adapters are designed to connect to an injector and constitute the syringe interface of the injector so that the injector can be used connected to a “new” syringe. As noted above, the “new” syringe is not designed for use with an injector and does not include an attachment mechanism configured to be used directly with the syringe interface of the injector. Once the adapter is installed so as to be operatively connected to the injector, a plurality of new syringes are generally used for the adapter (continuously).

  Unlike such adapters, the syringe adapter of the present invention is attached to a new syringe or syringe section, for example, prior to installation on an adapter that is operably connected to an injector. Furthermore, the syringe adapter of the present invention is configured such that one adapter cannot be used for multiple syringes. Before describing the adapter of the present invention, the operation of a representative injector (10) will be described in connection with the operation of a typical conventional syringe (100) (an exemplary embodiment of the adapter of the present invention). In connection with the injector used).

Those skilled in the art will recognize that the adapter of the present invention can be applied to virtually any injector and novel, simply by means of an injector interface mounting mechanism, an appropriate design of the adapter interface portion or injector interface portion of the adapter, and an appropriate design of the syringe interface portion of the adapter. It will be appreciated that it can be used with a simple syringe or syringe part.
In this regard, the syringe adapter of the present invention includes a syringe interface that includes a syringe that interacts with and is connected to a new syringe portion, and an injector interface that allows the adapter to operate on the syringe interface of the injector. Including rear part to connect to. Injector interfaces generally have a structure that approximates the mounting mechanism (e.g. flange structure) found in conventional syringes (so that such conventional syringes are attached to the syringe interface of the injector)

FIGS. 1A-1C are injectors that find commercial use for the STELLANT ™ described, for example, in US Pat. Nos. 6,652,489 and 7,462,166, available from Medrad, Indianola, Pennsylvania. The syringe interface (20) is shown. For example, referring to FIG. 1D, a conventional syringe (100) includes a body or barrel portion (110) that includes a rear end (120) and a front end (130) that includes a fluid outlet or outlet (132). Have The tab, attachment member, or attachment flange (122), is adjacent to the rear end (120) of the syringe (100) or is connected to the barrel portion (110) at the rear end.
In addition, a flange (140) (often referred to as a drip flange) is positioned in front of the mounting flange (122) to facilitate engagement of the syringe (100) to the syringe interface (20), and / or, for example. Alternatively, it is preferable to prevent fluid discharged from the outlet or outlet (132) of the syringe (100) from entering the injector (10) via the syringe interface (20) (see, for example, U.S. Pat.No. 5,383,858). As described).

As described in U.S. Pat.No. 6,652,489, the syringe interface (20) is deployed between the rear plate (24) and the front plate (26) to cooperate with the mounting flange (122) of the syringe (100). A flexible retaining ring (22) is provided. When the rear end (120) of the syringe (100) moves backward through the opening (28) of the syringe interface (20), the mounting flange (122) contacts the ring (22) and bends it. The mounting flange (122) includes a sloping portion and a shoulder portion substantially orthogonal to the outer surface of the cylindrical barrel portion (110).
The rear ledge or surface of the retaining ring (22) will engage the front or shoulder of the mounting flange (122) of the syringe (100) when the syringe (100) is fully attached to the syringe interface (20). It is configured. At least one, preferably two or more extension tabs or protrusions (128) are provided at the rear end of the syringe (100). As described in US Pat. No. 6,652,489, when the syringe (100) rotates, the tab or protrusion (128) allows the syringe (100) to be disengaged from the syringe interface (20).

For example, with reference to FIGS. 1A-1D, the terms “axial”, “axial” as used herein to describe various embodiments of the injector 10, syringe 100, and syringe adapter of the present invention. ”,“ Longitudinal ”,“ longitudinal ”or similar words generally refers to an axis A around which, for example, a conventional syringe (100) and injector drive member (60) are formed, and the axis A Point in the same straight line or parallel direction.
The terms `` back '', `` backward '' or similar words refer to the axial or longitudinal direction to the end of the injector (10) opposite the end to which the syringe (100) (or the adapter of the present invention) is attached. Abbreviated. The terms “previous”, “previous” or similar words generally refer to the axial or longitudinal direction to the syringe outlet or outlet (132).
The terms “radial”, “radial” or similar words generally indicate a direction perpendicular to an axis, such as axis A.

The injector (10) further includes a sensor assembly (50) operably connected to the syringe interface (20), the operation of which is described in US Pat. No. 7,462,166. The sensor assembly (50) is located with the seating (30) of the injector (10) in the vicinity of the syringe interface (20).
As described in US Pat. No. 7,462,166, the sensor assembly (50) includes a light emitter or light source (52) such as a light emitting diode. The light source (52) is electrically connected to a printed circuit board (54) that controls the operation of the light source (52). The sensor assembly (50) also includes a plurality of sensors (56a)-(56e). Light from the light source (52) travels or propagates axially through the light transmissive / semi-transparent wall of the syringe (100). Indicators Indicator such as (124a) (124c), as described in U.S. Patent No. 7,462,166, in the predetermined position to reflect light to the sensor (56a) (56c), the information of the configuration of the syringe And control the system (80) of the injector (10).
The position of the indicator (and thereby the position of the sensor where the indicator reflects light) can correspond to, for example, a binary code associated with the syringe configuration.

As used herein, the term “syringe configuration” includes information about the mechanical properties of the syringe (eg, material, length and diameter) as well as information about the contents of the syringe (eg, quantity and composition). Used to contain all information about a particular syringe (or syringe assembly as described herein).
With the advent of new syringes and in particular with prefilled syringes, there is an increased need to accurately encode and sense (or read) syringe configuration variables.
The syringe configuration information is used by the injector (10) to control the injection procedure as a function of the predetermined syringe configuration / injection parameters. In addition, a record of the data related to the infusion procedure is stored to meet the requirements for accurate billing and cost information, eg under supervised medical care.
Records of syringe used, amount of contrast agent used, type of contrast agent used, sterilization date, expiration date, lot code, contrast agent characteristics, and / or other clinically relevant information Such information is maintained.
Such information can be recorded digitally for sharing with computerized hospital billing systems, inventory systems, control systems, and the like.

  In FIG. 1C, the drive member or piston (60) of the injector (10) is shown operably connected to the syringe plunger (160) of the syringe (100). As described in published U.S. Patent Application No. 2004/0064041, as the piston (60) advances toward the plunger (160), the biased (e.g., spring loaded) sensing pin (62 ) Contacts the rear or inner surface of the plunger cover (62). The pin (62) is pushed and violates the area of the sensor (64) (eg optical sensor). The sensor (64) sends a signal to the control system (80) of the injector (10), and the control system (80) stops the advance of the piston (60) after a predetermined time or after a predetermined distance of the piston (60). The piston (60) engages with the plunger (160), but the advancement of the piston (60) stops before the movement of the syringe plunger (160). The piston (60) also includes a retractable pin (66), the pin (66) being one or more formed around the inside of the plunger base (166) when the piston (60) is pulled. Connected adjacent to the protrusion, flange or groove (164), thereby retracting or moving the syringe plunger (160) with the piston (60) backward. In FIG. 1C, for example, the pin 66 on the piston 60 is shown as extending and connects to the plunger 160 of the syringe 100.

  As the piston (60) advances and the plunger (160) advances through the syringe (100) (e.g., to discharge air or fluid contained within the syringe (100)), the piston (60) As the pin advances and engages the plunger (160), the pin (66) remains in the retracted state. If retraction of the plunger (160) is desired, the pin (66) extends to contact the ridge (164).

  2A through 2F show an example of a syringe adapter (200) operable to be suitable for a novel syringe or syringe section used for the syringe interface (20) of the injector (10). The syringe adapter (200) is pre-filled with 125 ml ULTRAJECT ™ available from Covidien, Mansfield, Mass. (Ie, filled with infusion fluid / contrast media before being delivered to the end user) Shown to be used for a representative example of a novel syringe or syringe section in the form of a syringe (100a).

In the illustrated embodiment, the syringe (100a) includes a body or barrel portion (110a), which has a rear end portion (120a) and a front end portion (130a) that includes a fluid outlet or outlet (132a).
The octagonal flange (123a) extends radially outward from the barrel portion (110) located adjacent to or at the rear end portion (120a) of the syringe (100a). The plunger (160a) is slidably positioned in the syringe belleb portion (110a). In the case of a prefilled syringe (100a), the plunger (160a) is generally located near the rear end of the syringe barrel portion (110a).

The syringe adapter (200) cooperates with the flange (123a) to operably connect the syringe adapter (200) to the new syringe (100a). In the embodiment shown in FIGS. 2A-2D, the syringe adapter 200 is formed in at least two parts. In this regard, the first part (210) and the second part (250) are interconnectable and engage the flange (123a), enclose and capture the flange, thereby allowing the syringe (100a) to be attached to the adapter (200 ) Firmly attached.
The first part (210) interacts with the syringe (100a) (and the second part (250)) to attach the syringe (100a) to the front part (212) and the adapter (200) to the syringe interface ( 20) including a rear or injector interface portion (240) operatively connected.
The first portion (210) is dimensioned to receive and seat the flange portion (123a) when the syringe flange (123a) is lowered into the seating (214) (in the orientation shown). )including. The flange (123a) is brought into contact with the front surface and the rear surface of the seating (214) to prevent the syringe (100a) from moving backward and forward with respect to the adapter (200).
The second portion (250) also includes a sheeting or face (254) (see, eg, FIG. 2B) that contacts at least a portion of the syringe flange (123a). A part of the syringe flange (123a) in contact with the surface (254) is located between the rear facing surface of the sheeting (254) and the front facing surface (216) of the first portion (210). The front end (212) of the first portion (210) includes a passageway (213) through which the extension (162a) and flange (164a) of the plunger (160a) can pass, as described below, the plunger adapter Form a connection to cooperate with (290).

The second portion (250) includes a laterally extending portion (260) dimensioned to slide within a passage or slot (220) of the first portion (210). A connector or locking element (262) that includes an enlarged end (264) that extends downward (orientation in the figure) is a passage, seating, or positioning element (210) in the first portion (210), as shown in FIG. 2C. 224) with an interconnect, locking or snap fit.
In some embodiments, if the second portion (250) is removed from connection with the second portion (210), the expansion connector (262) (and / or other portion of the adapter (200) may be removed. ) One or both of them, which is evidence that the adapter (200) is unusable. In general, the syringe adapter (200) cannot be removed from the syringe part (100a) under the force of normal storage, transportation, use, etc. The connection cannot be removed.
Furthermore, if it is attempted to remove the syringe adapter (200) from the syringe part (100a), the result will be the damage as described above.

In general, a snap fit is a mechanical joint system where positioning and locking configuration is achieved with a part-to-part connection (often referred to as a forced feature) and one or the other of the elements is typically joined homogeneously. The Connecting generally requires at least one flexible locking configuration that flexes or moves to engage the coupling portion, and then the locking configuration returns to its original position, latching the elements together Make the necessary interference to do.
The positioning configuration is a second cooperating forced configuration that is generally inflexible and provides strength and stability to the fixture. The snap fit is designed to form a number of removable connections or to form a single permanent connection (generally it cannot be removed without breaking).

  The second portion (250) also includes a front enlarged central portion (270) dimensioned to slide within the central slot (230) of the first portion (210). When the first part (210) and the second part (250) are connected, the arc surface (232) of the first part (210) and the arc surface (272) of the second part (250) are connected to the syringe barrel (110a). Surround the circumference.

The rear of the first part (210), ie, the injector interface (240) is the rear of the conventional syringe (100) that operably connects the syringe adapter (200) (and syringe (100a)) to the syringe interface (20). Includes elements corresponding to the elements of the piston (120). In this regard,
Mounting flange (242) corresponds to mounting flange (122) and operates in a manner similar to mounting flange (122).
Indicator (244b) and (244e), the indicator of the syringe (100) (124a) corresponding to (124c), the indicator (124a) (124c) that operates in a similar manner (and thereby sensing system (60) The configuration of the adapter (200) / syringe (100a) is shown in the injector control system (80).
Further, the projecting tab (246) corresponds to the projecting tab (128) of the syringe (100) and operates in a similar manner as the projecting tab (128), from the operable connection with the syringe interface (20) to the adapter ( Allows to remove 200b). At the rear end of the first portion (212), a radially extending ledge (248) corresponds to the flange (140) of the syringe (100) and operates in a manner similar to the flange (140).
The rear or injector interface portion (240) further includes a generally central passage (249) through which the piston (60) can be retracted along with the plunger (160a).

2A, 2B, and 2F show an exemplary embodiment of a plunger adapter (290) or plunger interface used for the injector (10) and syringe (100a).
The plunger adapter (290) has a rear (292) that mimics or mimics the interaction of the rear surface of the plunger cover (162) of the plunger (160) with, for example, the piston (60) and the sensing pin (62). Including. The plunger adapter (290) further includes a front enlarged portion (294) and a front plunger contact portion (296). As with other elements of the plunger adapter (290), the length of the enlarged portion (294) can be adjusted to match the characteristics of the individual syringe portions and / or syringe plungers.

  In the case of a prefilled syringe, such as a 25 ml ULTRAJECT ™ prefilled syringe (100a), there is no need to pull the plunger (160a). In this way, there is no need for the piston (60) to catch the rear (292) or to form a connecting connection with the rear (292), and the contact (296) catches the plunger (160a) or the plunger (160a It is not necessary to form a connection connection with). In this respect, if only the forward movement is applied to the plunger (160a), the rear part (292) simply acts as a contact surface, adjoins the drive member (60), and the contact part (296) merely serves as a contact surface. Operates and adjoins the plunger (160a).

However, those skilled in the art, for example, the rear portion (292) is formed similar to the plunger (160) and engages the pin (66) of the piston (60). For example, in the illustrated embodiment, the rear portion (292) of the plunger adapter (290) includes a generally conical surface (292a) that generally contacts the conical front surface of the drive member (60).
The rear portion (292) also includes a radially inwardly extending portion or ledge (292b) that contacts the pin (66) of the drive member (60) to allow retraction of the plunger adapter (290). Similarly, the contact element (296) includes one or more capture elements, or connectors, that connect to the plunger (160a) to allow for backward movement or retraction of the piston (160a).
In the illustrated embodiment, for example, the plunger adapter (290) includes a seating (296a) that cooperates with the rear flange (164a) on the rear expansion member (162a) of the plunger (160a). In the case of prefilled syringes, the syringe plunger is generally located farther from the rear in the syringe barrel. In the illustrated embodiment, the seating (296a) and the rear flange (164a) are easily connected during installation to connect the syringe (100a) to the syringe adapter (200).

  The injector drive mechanism, i.e. the engagement between the piston and syringe plunger, forms various other mechanisms (manual or automatic between the drive member, i.e. piston and plunger adapter, as well as manual or automatic engagement between the plunger adapter and syringe plunger). Which can be used for engagement) are disclosed, for example, in US Pat. No. 6,652,489 and US Patent Application No. 2004/0064041, the disclosures of which are incorporated herein by reference.

Novel syringes such as syringe (100a) can be made from a variety of materials including, for example, one or more polymeric materials, glass, metal, and the like. For example, a 25 ml ULTRAJECT ™ pre-filled syringe (100a) is made from polyethylene. In the embodiment described with respect to FIGS. 2A-2E, the first portion (210) and the second portion (250) can be made, for example, from a resilient polymeric material. In one embodiment, each first portion (210) and second portion (250) is made from polyethylene terephthalate (PET).
PET provides the necessary strength for high-pressure injection, such as occurs during CT contrast injection, while providing the optical translucency required for operation of the syringe adapter (200) with respect to a light or optical-based sensor assembly (50). To do.

  By using polymeric materials for the adapter (200) and other adapters of the present invention, a wide variety of simple and inexpensive manufacturing methods (e.g., injection) can be used for new or other syringes such as the syringe (100a). Molding) and assembly methods (eg, by snap fit, welding, adhesive, etc.) are provided.

Using one adapter per syringe increases safety (and thereby reduces the associated risk of cross-contamination) by reducing the possibility of reusing the same syringe for different patients. For example, the injector (10) can be programmed to not allow reuse of the adapter / syringe assembly previously used for the injector (10) (eg, as recognized by the sensor assembly (50)). The adapter of the present invention is provided or manufactured, for example, as a kit by a syringe manufacturer, which allows the syringe manufacturer to assemble adapter / syringe assemblies for use with a wide range of syringes and injectors.
The relatively inexpensive adapter / syringe assembly (or simply syringe assembly) of the present invention is disposed of after use, for example. The adapter allows a wide selection of contrast agents to be used for a particular injector.

As will be apparent to those skilled in the art, the adapter of the present invention is readily configured to modify or apply most syringe sections for use with most front loading injectors. For example, FIG. 2G shows the application or modification of the syringe (100a) used in either the syringe interface (20) of the injector (10) or the syringe interface of the injector disclosed, for example, in US Pat. No. 5,383,858. .
For example, the syringe interface disclosed in US Pat. No. 5,383,858 is used with a Medrad VISTRON ™ CT injector available from Medrad. A conventional syringe (100 ') includes a body or barrel portion (110') having a rear end (120 ') and a front end (130') having a fluid outlet or outlet (132 ').
Two mounting members, i.e. mounting flanges (122a ') (122b'), are adjacent to the rear end (120 ') of the syringe (100') or at the barrel (110 ') at the rear end (120'). ). In addition, the flange (140) (often referred to as the drip flange) is located at the front end of the mounting flange (122a ') (122b') and into the syringe interface of the injector of U.S. Pat. Preferably, fluids discharged from the outlet or outlet (132 ′) of the syringe (100 ′) are prevented from entering the injector via the syringe interface.

The syringe adapter (200 ′) is operatively connected to the syringe adapter (200 ′) of the new syringe (100a) in cooperation with the flange (123a) of the new syringe (100a). In the embodiment shown in FIG. 2G, similar to the syringe adapter (200), the syringe adapter (200 ′) engages the flange (123a) and is formed in at least two parts that can be interconnected to enclose or capture. Is done.
The front end (212 ′) of the first part (210 ′) has the same configuration and operation as the front end (212) of the first part (210) of the syringe adapter (200). The elements at the front end (212 ′) are labeled in the same manner as the elements at the front end (212), and the display “′” is added. The second part (250 ′) is also identical in construction and operation to the second part (250) of the syringe adapter (200). The elements of the second part (250 ′) are labeled in the same way as the elements of the second part (250) and are appended with the indication “′”.

  The rear part or injector interface part (240 ') of the first part (210') includes elements corresponding to the elements of the rear part (120 ') of the new syringe (100'), and the syringe adapter (200 ') (and the syringe) (100a)) is operably connected to the syringe interface of US Pat. No. 5,383,858. In this respect, the mounting flanges (242a ′) and (242b ′) correspond to the mounting flanges (122a ′) and (122b ′) and operate in the same manner as the mounting flanges (122a ′) and (122b ′).

In addition to retrofitting new syringes, for example, commercially available syringes used for various front loading injectors, the syringe adapter of the present invention can be used for syringe blanks or generic syringes to provide one of the various injector interfaces. Modify or modify the syringe blank used for one. The syringe blank need not correspond to, for example, a new syringe available on the market, and need not be usable for any injector (without modification).
The term “syringe” or “syringe part” as used herein refers to a fluid container having a barrel part containing a fluid to be pressurized and an outlet through which the fluid can come and go. For example, the term includes both the novel syringes and syringe blanks described herein.

An example of a syringe blank (300a) is shown in FIGS. 2H and 2I. The body or barrel part (310a) and front end part (330a) (fluid outlet or outlet (332a)) of the syringe blank (300a) correspond to the syringe (100 ′) and / or the syringe (100) shown in FIG. 2G. It is almost identical to the element. Syringe manufacturers that produce various syringes used for different injector interfaces, for example, make one syringe blank (or purchase from another manufacturer) and use that syringe blank, for example, as shown in FIGS. 2H and 2I. Could be modified or modified to produce a syringe assembly for use with one of the injector interfaces, simplifying the manufacturing procedure and reducing manufacturing costs.
In general, for use with a syringe blank (300a) (having a rectangular flange (323a) relative to an octagonal flange), the syringe adapter (200 ') seating (214') and the syringe adapter (200) seating (214) needs to be modified somewhat. FIG. 2J shows a perspective view of another syringe portion (300a) of substantially different amounts, including a rear flange (323a ′) used for the syringe adapter of the present invention, for example as shown in FIG. 2H or FIG. 2I.

  Again, portions of the syringe adapter of the present invention can be easily formed from polymeric materials such as polyethylene terephthalate (PET), polycarbonate, and other polymeric materials by a molding process (eg, injection molding). Forming the syringe assembly of the present invention is cheaper than an integral syringe that includes an injector mounting mechanism, as is often done by integral injection molding or now.

For example, in the case of the syringe interfaces disclosed in U.S. Pat. Attach the syringe to the syringe interface or remove the syringe from the connection with the syringe interface. For new syringes and syringe blanks that include non-circular (e.g., octagonal, oval, etc.) rear flanges, the collaborative sheeting of the syringe adapter of the present invention allows the syringe part after the syringe adapter is connected to the syringe part. The size is determined or dimensioned such that (eg, a new syringe or syringe blank) cannot rotate relative to the syringe adapter. In this way, the user can still grip the syringe barrel of the syringe portion of the syringe assembly, rotate the entire syringe assembly, attach the syringe assembly to the syringe interface of the injector, and / or connect the syringe assembly from the syringe interface. Remove. In the case of the syringe part (300b), as shown in FIG. 2K including a circular rear flange (323b), a seating (214 '') is provided in the syringe adapter (200 ''), and the syringe adapter (200 '' It is somewhat more difficult to prevent rotation of the new syringe or syringe blank (300b) relative to
In the case of the syringe interface disclosed in U.S. Pat. The user simply holds the syringe adapter of the present invention, rotates the syringe adapter, and removes the syringe adapter from connection with the syringe interface. Gripping elements known in the art (e.g., jagged areas or enlarged flanges not shown) are deployed on the syringe adapter of the present invention to facilitate gripping of the syringe adapter and rotation relative to the syringe interface.
Alternatively, for example, a mechanism that engages the syringe part (300b) is incorporated in the syringe adapter (200 ″) to prevent rotation of the syringe part (300b) relative to the syringe adapter (200 ″). For example, in the embodiment shown in FIG. 2J, the syringe adapter (200 ″) includes a flexible ring (215 ″) that includes a grip or gripping member such as a tooth (215a ″). When the adapter (200 ″) is connected to the syringe part (300b), the teeth (215a ″) of the flexible ring (215 ″) are connected to the first part (210 ″) and the second part (250 ′). It is pushed by the peripheral edge of the flange (323b) by ') to prevent the syringe part (300b) from rotating with respect to the syringe adapter (200 ″).
In other embodiments, the syringe adapter (200 '') operates in a manner similar to the syringe adapter (200 '), and the elements of the syringe adapter (200'') are the corresponding elements of the syringe adapter (200'). It is encoded in the same way as, and replaces the display "'" with "".

  For example, a non-circular member (323b '), shown in dotted lines in FIG. 2K, is used to help form a connection between the syringe adapter of the present invention and the syringe part, which is the size of the syringe adapter sheeting. And / or having rear flanges of different shapes. In the embodiment of FIG. 2K, the member (323b ') cooperates with the flexible ring (215 ") to engage the syringe part (300b), and the syringe part (200") Block rotation of 300b).

  The syringe adapter of the present invention need not cooperate with the rear flange of the syringe portion described for the above embodiment. The syringe adapter of the present invention can, for example, cooperate with certain locations in the syringe where a change in radius occurs throughout. For example, the syringe adapter of the present invention forms a contact connection that cooperates with the forward transition region (328b) of the syringe portion (300b) (see, eg, FIGS. 3G and 3H and the following description).

  3A and 3B show another example of a syringe adapter (200a) used for a 25 ml ULTRAJECT ™ pre-filled syringe (100a). In many embodiments, the syringe adapter (200a) operates in a manner similar to the syringe adapter (200), and some elements of the syringe adapter (200a) are labeled similar to elements of the syringe adapter (200). Display "a" is added.

Similar to the syringe adapter (200), the syringe adapter (200a) cooperates with the flange (123a) to form an operable connection with the syringe (100a). In the embodiment shown in FIGS. 3A and 3B, the syringe adapter 200a is formed in at least two parts, a first part 210a and a second part 250a, the two parts being interconnectable. Engage and enclose or capture the flange (123a).
The first part (210a) interacts with the syringe (100a) to connect the front part (212a) to the syringe (100a) and the rear part or the adapter (200a) to the syringe interface (20). Injector interface section (240a) is included. The rear part or the injector interface part (240a) is substantially the same in configuration and operation as the injector interface part (240), and operates in the same manner as the rear end part (120) of the conventional syringe (100), and the adapter ( 200a) is connected to the syringe interface (20) of the injector (10).
In this regard, the mounting flange (242a) operates in a manner similar to the mounting flange (122) corresponding to the mounting flange (122). Indicator (244ab) (244ae) corresponds to the indicator of the syringe (100) (124a) (124c) operates an indicator (124a) (124c) and similar methods, in cooperation with the sensing assembly (50), The configuration of the adapter (200a) / syringe (100a) is identified and / or the configuration is shown to the injector control system (80).
Furthermore, the protruding tab (246a) corresponds to the protruding tab (128) of the syringe (100) and operates in the same manner as the protruding tab (128), and operates with the syringe interface (20) of the adapter (200a). Allows release from possible connections. A radially outwardly extending ledge (248a) at the rear end of the first portion (212a) operates in a manner similar to the flange (140), corresponding to the flange (140) of the syringe (100).

  The first location (210) includes a generally octagonal seating (214a) formed in its first portion (212), the seating being dimensioned to receive an octagonal flange (123a). The rear surface of the flange (123a) is in contact with the front facing surface of the sheeting (214a). The second location (250a) also includes a rear facing surface (254) (see, eg, FIG. 2B) that contacts the front facing surface of the syringe flange (124a). The syringe flange (123a) is thereby positioned between the rear facing surface (254) and the front facing surface of the sheeting (214).

The second portion (250) includes a generally circular passageway (253a) dimensioned to have a diameter that is much larger than the outer diameter of the syringe barrel (110a). During assembly, the syringe flange (123a) sits on the seating (214a) and the second part (250a) is placed on the syringe (100a) and moves backward (the syringe barrel (110a) opens through the opening (253a). Pass through). A radially inwardly extending flange or locking element (257a) on the rearward enlargement (259a) of the second part (250a) bends outwardly upon contact with the first part (210a), eg, FIG. As shown in FIG. 3, a bulge (217a) of the first portion (210a) and a snap fit are formed.
For example, the first portion (210a) has a chamfer (215a) on its front surface to facilitate radially outward deflection of the flange (257a) and extension (259a). Once the first part (210a) and the second part (250a) are firmly engaged, the rear surface of the seating (254a) of the second part (250a) is adjacent to the syringe flange (123a) as described above. Thus, the forward movement of the syringe (100a) with respect to the adapter (200a) is prevented. The syringe flange (123a) is thereby captured or captured between the first part (210a) and the second part (250a).

  The 90 ° angle of the front surface of the flange (257a) (with respect to the long axis of the syringe part) is a permanent snap fit. In this way, the attempt to remove the second part (250a) from the connection with the first part (210a) can be achieved by the flange (257a), the extension (259a), or the first part (210a) or the second part (250a). ) Other parts are damaged, leaving evidence of tampering and making the adapter (200a) unusable. One or more parts of the adapter (200a) are designed so that they will not function, for example, during tampering or attempts to remove the syringe (100a).

3C-3E show another embodiment of a syringe adapter (200a ') that is similar in construction to the syringe adapter (200a). In general, the only difference between the syringe adapter (200a ') and the syringe adapter (200a) is that the first part (210a') is not a ledge (217a) of the first part (210a) but projects inwardly or radially inwardly The concave ring or groove (217a ′) is connected to the flange (257a ′) of the second part (250a ′) in cooperation. Any attempt to remove the second part (250a ′) from the first part (210a ′) makes it more difficult to access the flange (257a ′) by the groove (217a).
In other embodiments, the syringe adapter (200a ′) operates in a manner similar to the syringe adapter (200a), and the elements of the syringe adapter (200a ′) are labeled with the symbol “′” on the elements of the syringe adapter (200a). The same reference is made in the same manner as the one to which is added.

FIG. 3F shows the use of a third portion (260a ′) that surrounds at least the front end (212a ′) and a portion of the extension (259a ′), which is generally cylindrical or annular in shape. The third part (260a ') restricts access to the snap-fit element before use, during use or after use, and prevents the radially outward deflection of the extension (259a'), thereby preventing the first part. Helps ensure that the snap fit between (210a ') and the second part (250a') remains permanent.
The third portion (260a ′) is, for example, a carbon reinforced tape band or a flexible open annular member (eg, a permanent snap fit seal) that includes a sealing mechanism.

In an injection procedure, such as an angiographic injection procedure, the pressure in the syringe barrel is relatively high (eg, about 1500 psi or less). Such high pressure injection causes a portion of the wall of the polymeric syringe barrel to bulge or expand, resulting in a phenomenon called “capacity” or “stored energy” in the system.
In extreme cases, dentition or damage occurs as a result of high pressure. As is known in the art, a pressure jacket is used to surround at least a portion of the syringe barrel to support the syringe barrel (see, eg, PCT International Publication No. WO 2004/058332).
3 and 3G illustrate the use of the pressure jacket assembly (270a ′) for the first portion (210a ′). In the illustrated embodiment, the pressure jacket assembly (270a ') includes a first generally cylindrical member (270a') having an inner diameter that is much larger than the outer diameter of the syringe barrel (110a). And configured to support the syringe barrel (110a). The first member (270a ′) is cantilevered and includes an inwardly extending flange or locking element (274a ′) to form a permanent snap fit with the groove (217a ′). The pressure jacket assembly (270a ′) also includes, in front, a second generally cylindrical or generally annular member (280a ′) that is cantilevered and has an inwardly extending flange or locking element (282a). ') To form a permanent snap fit with the groove (276a') of the first cylindrical member (272a ').

  FIGS. 3G and 3H also illustrate one method for engaging the front end of the syringe portion, where the radius of the syringe portion varies across the front end. For example, such engagement is made in a syringe portion that does not include a rear flange (such as flange 123a).

4A and 4B show another example of a syringe adapter (200b) used for a representative example of a ULTRAJECT ™ pre-filled syringe (100a). In many respects, the syringe adapter (200b) operates in the same manner as the syringe adapter (200a), and some elements of the syringe adapter (200b) replace the instruction "a" with the instruction "b". Corresponding elements of the syringe adapter (200a) are similarly referenced.
In the embodiment of FIGS. 4A and 4B, the syringe adapter (200b) is longitudinally divided into two generally similar parts or halves (210b). Part (210b) interacts with the syringe flange (123a) to attach the syringe (100a) to the front end (212b) and the adapter (200b) to the syringe interface (20) to operably attach the rear end ( 240b).
Within each portion (210b), a seating (214) is formed to seat a portion (ie, half) of the syringe flange (123a). During assembly, one of the portions (210b) can be operably placed on the syringe (100a) (ie, with the flange (123a) seated on the seating (214b)).
The rest of the portion (210b) is then carried to operably connect to the syringe (100a). Portions (210b) are then bonded together by ultrasonic welding, solvent welding, snap fit, adhesion, etc., as is known in the art of bonding and connecting polymer compounds.

As described with respect to the syringe adapter (200) (200a), the mounting flange (242b) corresponds to the mounting flange (122) and operates in a manner similar to the mounting flange (122).
Indicator (244bb) (244Be) corresponds to the indicator of the syringe (100) (124a) (124c) operates in the same manner as the indicator (124a) (124c), in cooperation with the sensing assembly (50), the adapter The configuration of (200b) / syringe (100a) is identified, and the configuration of the adapter (200b) / syringe (100a) is displayed on the injector control system (80).
Furthermore, the projecting tab (246b) corresponds to the projecting tab (128) of the syringe (100) and operates in a similar manner to the projecting tab (128), from an operable connection with the syringe interface (20) to the adapter ( Allows to remove 200b). At the rear end of the first portion (212b), a radially extending ledge (248b) corresponds to the flange (140) of the syringe (100) and operates in a manner similar to the flange (140).

  In some embodiments, the first and second portions of the syringe adapter of the present invention are carried together and attached at a non-zero angle with respect to the major axis of the barrel portion of the syringe portion. For example, in the case of the syringe adapters (200) and (200b), the first part and the second part of the syringe adapter are carried together to be attached, and the syringe is at an angle substantially perpendicular to the long axis of the barrel part of the syringe part. Engage with the part. Connecting a portion of the syringe adapter of the present invention at an angle to the axis of the syringe barrel distributes around the periphery of the adapter and / or shifts the direction of partial connection of the syringe adapter during the connection and injection procedure. As a result, a force is generated (as a result of the forward movement of the injector drive member and the connected syringe plunger) and the possibility of disengagement is reduced (eg, by snap connection or disengagement of the adhesive seam).

  The foregoing description and accompanying drawings describe the preferred embodiment of the present invention. Various modifications, additions and alternative designs will, of course, be apparent to those skilled in the art in light of the above disclosure without departing from the scope of the invention. The scope of the invention is indicated by the following claims rather than by the foregoing description. All changes and modifications that come within the meaning and range of equivalency of the claims are to be embraced within their scope.

Claims (34)

A syringe assembly connectable to an injector,
A first adapter section defining an open slot ;
Formed to fit enter sliding into an open slot, and a second adapter portion separating,
A snap connector Ru coupled with the first adapter portion and a second adapter portion,
Have
The second adapter portion includes a side extending portion formed so as to slide into the open slot.
The first adapter portion, the second adapter portion, or a combination thereof is configured such that the front portion is configured to be attached to the rear end of the syringe and the rear portion is configured to operably connect the syringe assembly to the injector syringe interface. Moreover, it is arranged to cooperate with the detection system, which comprises an indicator which is positioned at a predetermined position to reflect light, the syringe assembly.   The syringe assembly according to claim 1, wherein a rear end of the syringe part has a flange, and the first adapter part, the second adapter part or a combination thereof is configured to be coupled to the flange. The syringe assembly according to claim 1, wherein the first adapter part and the second adapter part are attachable via a mechanical connection. The syringe assembly of claim 1, wherein the first adapter portion and the second adapter portion are carried together and attached at a non-zero angle with respect to the long axis of the barrel portion of the syringe. The syringe assembly according to claim 1, wherein the first adapter part and the second adapter part are carried together and attached at an angle orthogonal to the long axis of the barrel part of the syringe. The syringe assembly according to claim 1, wherein each of the first adapter part and the second adapter part is formed of a polymer material. A first adapter part each of the second adapter portion are separately formed via a molding process, a syringe assembly according to claim 1. The syringe assembly of claim 2, wherein the flange is non-circular and the first adapter portion and the second adapter portion engage the flange so that the syringe portion cannot rotate relative to the first adapter portion and the second adapter portion . . The syringe assembly according to claim 1, further comprising a third portion engageable with the first adapter portion and the second adapter portion .   And a passage operatively connected to the barrel portion after being connected to the syringe portion, and upon connection of the syringe assembly, the drive member operates a plunger that can be slidably positioned within the syringe through the passage. Item 2. The syringe assembly according to Item 1. A method of forming a syringe assembly connectable to a first injector having a first syringe interface and a first drive member comprising:
Deploying a syringe comprising a barrel to contain fluid to be pressurized and an outlet connected to the barrel for fluid flow;
The syringe comprises the steps of deploying a separately formed adapter, the adapter includes a first part component defining an open slot, which is formed to fit enter sliding into open slots, separated has a minute second part has, part 1 minute is a couplable to part 2 minutes, part 1 minute and second part component binds at least a first portion component and a second part component ingredients to give a snap connectors for each part component is configured to be attached to the rear end of the syringe, the second portion, which is formed to fit enter sliding into an open slot, a portion extending laterally comprises , the rear is composed of the syringe assembly to operably couple to the injector syringe interface, rear cooperate with further detection system, an indicator which is positioned at a predetermined position to reflect light ingredients el, the steps,
Placing the rear end of the syringe in the adapter;
Sliding the second part into the open slot of the first part to form a bond between the first part and the second part and connecting the adapter to the syringe part;
The painting tool, a method of forming a syringes assembly connected to the injector.   The method of claim 11, wherein the syringe includes an attachment mechanism configured to be connected to a second injector that includes a second syringe interface that is different from the first syringe interface of the first injector. A kit capable of operably connecting a syringe to an injector,
Comprising an adapter comprising a first adapter portion capable of binding to a second adapter portion separated,
The first adapter portion defines an open slot and the second adapter portion is formed to slide into the open slot;
The second adapter portion includes a side extending portion formed so as to slide into the open slot.
The first adapter portion has a front portion configured to attach to the rear end of the syringe and a rear portion configured to operably couple to the injector syringe interface, the rear portion further cooperating with the detection system; and comprises an indicator which is positioned at a predetermined position to reflect light,
Kit that allows a syringe to be operably connected to an injector. The syringe assembly of claim 1 , wherein the rear portion has a mounting flange. The syringe assembly of claim 1, wherein the front portion includes an attachment portion configured to carry at least a portion of a syringe flange at the rear end of the syringe. Rear portion, immediately a projecting tab capable of separating assembly from the injector syringe interface Eteiru, syringe assembly of claim 1. The syringe assembly of claim 1, wherein the rear portion has a radially extending protruding edge.   The syringe assembly of claim 1, wherein the indicator displays the shape of the syringe relative to the injector.   The syringe assembly of claim 1, wherein the indicator corresponds to a binary code. The syringe assembly of claim 1, wherein the syringe assembly comprises an optically transparent polymeric material. The syringe assembly of claim 1, wherein the first adapter portion and the second adapter portion have two halves of the syringe assembly that are substantially identical in shape . Further ingredients plunger adapter Eteiru, syringe assembly of claim 1. The syringe assembly of claim 1, wherein failure occurs when the first adapter portion is removed from the second adapter portion. The syringe assembly of claim 1, wherein failure occurs when the first adapter portion and the second adapter portion are removed from the syringe. When removing the first portion and the second portion from the syringe, breakage occurs The method of claim 11.   12. The method of claim 11, wherein the indicator displays the shape of the syringe relative to the injector. Indicator corresponds to a binary code method of claim 12. The method of claim 11, wherein the syringe assembly comprises an optically clear polymeric material. 14. The kit of claim 13 , wherein breakage occurs when the first adapter part is removed from the second adapter part. 14. The kit of claim 13, wherein breakage occurs when the first adapter portion and the second adapter portion are removed from the syringe. Furthermore the plunger adapter ingredients Eteiru The kit of claim 13.   The kit of claim 13, wherein the indicator displays the shape of the syringe relative to the injector.   The kit of claim 13, wherein the indicator corresponds to a binary code.   14. The kit of claim 13, wherein the assembly comprises an optically clear polymeric material.

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