JP5610312B2 - Packaging container - Google Patents

Description

  The present invention relates to a packaging container that supplies a sufficient amount of a medium during transportation of a biological sample and reduces the influence of nutrients supplied to the biological sample and discharged matter. For example, the present invention relates to a packaging container that supplies a sufficient amount of culture medium to a biological sample in transportation of a biological sample including a regenerated tissue or the like manufactured in a cell processing facility.

  Regenerative medicine that restores the function of organs and the like using a biological sample such as a regenerated tissue produced using cells as a raw material is expected as a radical treatment method for diseases for which there has been no conventional treatment method. The manufacturing process of biological samples such as regenerative tissues used for regenerative medicine is based on Good Manufacturing Practice (GMP), which is a standard for manufacturing management and quality control of pharmaceuticals and the like. Manufacture is performed at the Cell Processing Center (CPC) and follows the Standard Operational Procedure (SOP) that satisfies GMP. In Japan, laws and regulations established by the Ministry of Health, Labor and Welfare are enforced in GMP (for example, Ministry of Health, Labor and Welfare Order No. 179, Yakuhatsu No. 480). Outside Japan, relevant laws and regulations are being implemented mainly by Western institutions (eg, US Food and Drug Administration, European Commission).

CPC operation requires human resources with significant costs and specialized culture techniques. Therefore, at the stage of practical application of regenerative medicine, regenerative tissue is produced with a small number of CPCs as production bases, and the produced biological samples are transported to various medical institutions and research institutions for use in patient treatment or research. it is conceivable that.
When applying a biological sample to a living body, for example, when treatment is performed, the biological sample after transport needs to maintain a good state with respect to an index such as metabolic function or cell viability. Regenerated tissue produced by CPC is immersed in the medium. The medium supplies nutrients to the biological sample. In addition, the biological sample discharges substances such as lactic acid involved in metabolism into the medium. If the amount of the medium being transported is small, there is a risk that the nutrients of the medium will be depleted, the concentration of the effluent will rise, and the pH of the medium will be particularly acidified by lactic acid. When the treatment is performed, in order for the biological sample to be in a good state, it is necessary to supply a sufficient amount of medium during transportation.

  There are several reports regarding the transport / packaging technology of biological samples such as regenerative tissues as conventional technology against the above background. Patent Document 1 discloses a technique relating to a culture vessel in which an aggregated biological sample can be partitioned so as not to further aggregate, and a culture medium is supplied to the partitioned region via a membrane filter. .

  Patent Document 2 discloses a technique relating to a culture container that has a pressing device that prevents a biological sample from coming out of the culture vessel, and the pressing device supplies a culture medium to the biological sample through the membrane portion. .

JP 2010-158214 A JP 2003-180335 A

  In the method described in Patent Document 1, a culture medium is supplied through a membrane filter to a region where an aggregated biological sample is partitioned. The amount of medium that can be supplied depends on the volume of the culture vessel to be used. When transporting a biological sample using this culture vessel, it is difficult to change the amount of the medium according to the type and number of cells contained in the biological sample, especially when a large amount of medium is required. I can not cope. Further, when a biological sample is taken out from the culture container after transportation, a device for aseptically attaching a flow path tube for taking out the culture medium and aspirating it is further required.

  In the method described in Patent Document 2, a culture medium is supplied to a biological sample via a membrane part included in the pressing device. As in Patent Document 1, the total amount of the medium is determined by the volume of the culture container to be used. It cannot cope with the case where a large amount of medium is required. Furthermore, when a biological sample is transported using this culture container, the culture container leaks from the gap between the main body part and the lid part of the culture container when the culture container is tilted, and biological contamination occurs to the biological sample. Have danger.

  Therefore, an object of the present invention is to provide a packaging container that supplies a sufficient amount of medium to a biological sample being transported.

  In order to achieve the above object, the present invention has the following configuration.

The packaging container of the present invention comprises a packaging container main body portion that houses a sample container having a sample therein and holds it on the bottom surface, and a packaging container lid portion that seals the packaging container main body portion. The packaging container lid is provided with a medium holding part that is partitioned by a porous film and holds the first medium inside. By joining the packaging container main body and the packaging container lid, the packaging container lid seals the sample container. The medium holding section, when the sealing of the sample container according to prior Symbol packaging container lid, and a second medium in the interior of the sample container and the first culture medium of said medium holding portion is in contact via the porous membrane Is. In the porous membrane, substances absorbed or discharged by the cells contained in the first and second culture media can move in both directions.

  According to the packaging container of the present invention, it is possible to supply a sufficient amount of medium during transportation and maintain the state of the biological sample in good condition after transportation.

The figure which shows one Example of this invention and shows the structure which accommodated the sample container in the packaging container. The figure which shows one Example of this invention and shows the cross section of the vertical direction of the structure which accommodated the sample container in the packaging container, and a horizontal direction. The figure which shows other one Example of this invention, and shows a structure when not having a porous film between the cover part of a packaging container, and a sample container. The other example of the present invention is shown, and the figure showing the composition in case the width of the channel which connects a culture part and a tank part is large in the lid part of a packaging container. The figure which shows other one Example of this invention, and shows the structure which used a part of packaging container as the gas-permeable film. The other example of the present invention is a figure showing the composition which stored the sample container of various shapes in the packaging container. The figure which shows the structure of the cell transport container which transports the sample container packaged in the packaging container of this invention. The figure explaining an example which takes out the packaging container of this invention from CPC. The figure explaining an example which carries the packaging container of this invention into a medical institution etc. FIG.

  Hereinafter, embodiments of the present invention will be described with reference to the drawings. Note that components having the same function are denoted by the same reference symbols throughout the drawings for describing the embodiments, and the repetitive description thereof will be omitted.

  The basic components of the packaging container 100 will be described with reference to FIGS. 1 and 2. A sample container 104 containing a biological sample 120 such as a regenerated tissue is packaged by a packaging container main body 103 and a packaging container lid 101.

The materials of the packaging container main body 103 and the packaging container lid 101 need to be sterilized by sterilization. For example, when the packaging container is made of polystyrene, it can be sterilized by sterilization by γ-ray irradiation or ethylene oxide gas treatment before use.
In the above, polystyrene is taken as an example, but it goes without saying that it can be applied if it can be sterilized with a material that is not harmful to a biological sample.

FIG. 1A shows a packaging container lid 101. The packaging container lid portion 101 may be configured to have an elastic member 102 such as silicone or rubber in order to prevent the culture medium in the sample container 104 from leaking out.
The elastic member 102 is preferably of a medical use quality that can be sterilized by γ-ray irradiation, ethylene oxidide gas treatment, etc., and does not emit harmful substances. The elastic member 102 is preferably softer than the packaging container material, and when the sample container 104 described later is pressed against the packaging container main body 103, the sample container 104 is pressed against the bottom surface of the packaging container main body with an appropriate pressing force. It becomes possible. In addition, a screw receiving portion 110 for sealing the packaging container main body 103 is provided on the inner side surface of the packaging container lid portion 101. In addition, it cannot be overemphasized that it can hold | maintain by fixing a several location by fitting, pinning, a spring material etc. as another method of sealing.

  The sample container lid 101 is formed with a medium holding part 107 which is a space partitioned by the porous film 106 and holds the first medium 108. The culture medium holding part 107 is formed so as to protrude from the packaging container lid part toward the bottom surface of the packaging container main body part. The first medium 108 is connected to the medium supply unit 113 through the flow path 112. The culture medium supply unit 113 is provided with an injection suction port 114 for injecting or suctioning the culture medium. By attaching a cap or the like, the first culture medium can be injected and sucked as required. During transportation, it is possible to prevent medium leakage from the inlet / inlet port 114 by attaching a cap. Examples of the material of the porous film 106 include polystyrene and polycarbonate.

FIG. 1B shows the packaging container main body 103. The sample container 104 is held on the bottom surface of the packaging container main body 103. The sample container main body is provided with a guide 115 for sandwiching the sample container so that a place where the sample container is installed is uniquely determined. Further, the outer peripheral side surface of the packaging container main body 103 has a screw portion 111 that can be joined to the screw receiving portion 110 of the packaging container lid portion 101. The packaging container can be sealed by joining the screw portion 111 and the screw receiving portion 110 together. When the sample container is sealed, the screw portion can prevent the bacteria from entering the inside of the packaging container even if the bacteria adhere to the outside of the packaging container. Therefore, it is possible to avoid the occurrence of biological contamination on the biological sample in the sample container.
Further, in this example, an example in which sealing is performed by providing the screw portion 111 is shown. However, the present invention is not limited to this, and both may be sealed using a hook material or the like, It goes without saying that an elastic member such as rubber may be attached to the inner side surface to seal the lid member.

  FIG. 1C shows a sample container 104 into which a biological sample is introduced and stored. A second medium 105 is contained in the sample container 104. A biological sample 120 is contained in the second medium. There are many types of media, but examples of those that supply nutrients include, for example, KCM media for epidermal cells and corneal epithelial cells, and 10% serum-containing media for dermal fibroblasts. Examples of those that do not supply nutrients include PBS medium, physiological saline, perfusate used for organ transplantation, UW solution, etc., which have the same osmotic pressure as the inside of cells.

  Regarding culture environment, when a biological sample is cultured using a sample container, generally a lid is also used. The lid is provided with a gap so that a gas such as oxygen can enter from the outside of the sample container. Therefore, when this sample container is used for transportation, the culture medium leaks when the sample container is tilted. This causes biological contamination. Therefore, in this method, the lid of the sample container is changed to the packaging container lid portion 101. That is, the packaging container main body 103 and the sample container 104 held on the bottom surface of the packaging container main body 103 are sealed with the packaging container lid 101 to prevent leakage of the culture medium during transportation.

In order to seal the packaging container main body 103 and the sample container 104, it is desirable that the side wall of the sample container 104 and the side wall of the packaging container main body 103 have the same height. Thereby, it becomes possible to seal both only by the fastening force of the screw receiving part 110 of the packaging container lid part 101. Further, as described above, by attaching the elastic member 102 to the lid portion 101, the possibility of leakage can be further reduced.
Furthermore, if the height of the side wall of the sample container 104 is not the same, the difference in height can be absorbed by the elastic force of the elastic member 102. Even if the side wall of the sample container 104 is lower than the packaging container main body 103, a similar effect can be obtained by providing a convex portion at a position corresponding to the side wall of the lid 101 and making the shape of the elastic member 102 corresponding to that. Needless to say,

  FIG. 1D shows a state in which the sample container main body 104 is accommodated in the packaging container main body 103. The position of the sample container 104 is uniquely determined by the guide 115. FIG. 1E shows a state where the packaging container lid 101 is further attached and integrated with the packaging container main body 103 from the state of FIG. These can be integrated by a screw structure. At this time, the elastic member 102 is pressed against the sample container 104 by the tightening force of the packaging container lid 101. Thereby, even if the sample container 104 is inclined, the second culture medium 105 inside does not leak to the outside. In addition, the first culture medium 108 is in contact with the second culture medium 105 in the sample container, the porous membrane 106, and the flow path 112 by the culture medium holding unit 107 provided in the packaging container lid. This allows substances that are absorbed or excreted by the cells to move in both directions. That is, it becomes possible to avoid depletion of nutrients during transportation or acidification of the medium by lactic acid discharged from the biological sample.

  For supplying the culture medium to the packaging container 100, the sample container 104 is sealed in the packaging container main body 103 and the lid 101, and then the culture medium is introduced through the injection suction port 114. In a clean environment such as a safety cabinet, the injection suction port 114 is opened, and the medium is filled with the packaging container 100 tilted. The injection / suction port 114 is closed with no air layer inside. Transport in this state. After the transportation, the reverse procedure is performed to remove the medium in the packaging container 100 and the sample container 104, and then the package is opened. The amount to be removed is such that the biological sample 120 in the sample container 104 is immersed in the medium after opening. Further, when the packaging container lid 101 is lifted and separated from the sample container 104 at the time of opening, the medium does not rapidly pass through the porous film 106, so that the medium is held on the upper part of the porous film 106. The packaging container lid 101 can be removed. In this case, the medium may be removed later.

  FIG. 2 is a cross-sectional view in the vertical direction and the horizontal direction with respect to the state in which the sample container 104 shown in FIG. In this example, a cylindrical container generally used as a sample container is shown. Therefore, the packaging container and the parts related thereto are all concentric. For example, the culture medium supply unit 113 may have a rectangular shape or the like as long as it does not cause a steric hindrance upon integration with the packaging container.

  FIG. 3 shows another embodiment. In this embodiment, the packaging container lid 101 does not have a porous film. Thereby, the diffusion efficiency of the substance between the second culture medium 105 in the sample container and the first culture medium 108 in the packaging container lid is improved. On the other hand, in the opening operation after transportation, since the porous film 106 holding the first medium 108 is not provided in this example, the first medium 108 is completely removed from the injection suction port 114 before opening. There is a need. When the sample container 104 and the packaging container lid 101 are separated while the first medium 108 remains, the medium exceeding the capacity of the sample container 104 is left, and the medium leaks out of the sample solution. This is because it can cause biological contamination.

  FIG. 4 shows another embodiment. In this embodiment, the width of the flow path 112 is made larger than that of the configuration shown in FIGS. The channel 112 has a role of connecting the first medium 108 with the medium holding unit 107 and the medium supply unit 113. By increasing the width of the flow path 112, the diffusion efficiency of the substance in the first medium is improved. That is, the effect of supplying nutrients to the biological sample 120 and diffusing discharged substances is improved.

  FIG. 5 shows another embodiment. In this embodiment, a part of the packaging container lid portion 101 is a gas permeable membrane 501. The gas permeable membrane 501 is made of a thin film of polycarbonate, for example. The gas permeable membrane 501 makes it possible to take in a gas such as oxygen from the outside to the inside of the packaging container even during transportation. A biological sample is composed of various cells. For example, cardiomyocytes have a high oxygen demand. When transporting such cells, the state of the biological sample after transport is improved by supplying oxygen from the outside of the packaging container through the gas permeable membrane 501. It is also possible to control the pH of the medium by supplying carbon dioxide from the outside. In this way, by employing the gas permeable membrane 501 for the packaging container lid 101, it is possible to provide a packaging container that is transported while maintaining a good state for biological samples such as cells having high oxygen demand. .

  FIG. 6 shows an example of packaging other types of sample containers. FIG. 6A shows an example in which the insert-type sample container 601 is packaged. When cells are cultured using an insert-type sample container, generally, the insert-type sample container is placed in a 6-well plate or the like, and two-layer culture is performed. In transporting the insert-type sample container, an insert-type sample container 602 for storing the insert-type sample container is prepared, and only the insert-type sample container 601 is stored in the packaging container 100. In the insert type sample container 601, the culture medium can move through a thin film at the bottom, and the nutrients contained in the medium in the insert type sample container container 602 and the discharge from the biological sample can be diffused. The packaging container lid part is sealed by the tightening force of the screw receiving part 110 of the packaging container lid part 101. As another method, a plurality of places can be held by screws, fittings, pinning, spring materials, or the like. Although FIG. 6A shows a diagram in which one insert type sample container 601 is accommodated, a plurality of insert type sample containers 601 may be accommodated.

  FIG. 6B shows an example in which a 6-well plate 603 is packaged. Since the cylindrical sample container and the insert-type sample container have a circular cross section in the horizontal direction, they can be integrated with the packaging container body by rotating the packaging container lid. On the other hand, the 6-well plate has a rectangular parallelepiped shape. Therefore, in this figure, the screw 604 is used to fix and integrate the four corners of the packaging container. As another method, it goes without saying that it can be held by fixing a plurality of locations by fitting, pinning, spring material or the like.

  FIG. 7 shows a configuration example in the case of carrying out transport using a cell transport container capable of maintaining a constant temperature with a heat storage material for the sample container accommodated in the packaging container as described above. . In the cell transport container, a heat insulating material 703 is disposed inside a container main body 701 and a container lid 702 that house internal components. A heat storage material box 704 in which a heat storage material is enclosed is disposed inside. The heat storage material is preferably a pure substance having a constant melting point, or a substance having a large heat capacity and a small temperature change of the melting point (for example, ± 1 ° C. or less). This makes it possible to reduce the change width of the internal temperature during transportation, and the influence of the temperature on the biological sample is reduced.

As an example of the heat storage material, hydrocarbon which is a pure substance can be given. For example, the melting point of a hydrocarbon whose chemical formula is C ₂₀ H ₄₂ is 36.4 ° C. Hydrocarbons having different numbers of C have different melting points. Therefore, it is possible to change the temperature value that the cell transport container maintains constant by selecting the type of hydrocarbon.

  In the cell transport container, the sample container 706 accommodated in the packaging container disposed in the sample container accommodating part 705 at a location sandwiched between the heat storage material boxes 704, and the temperature, pressure, vibration, etc. during the transport. A monitoring device 707 to be evaluated is arranged. Thereby, it becomes possible to confirm the environment under transportation after transportation.

  8 and 9 schematically show how the packaging container shown in the present embodiment is transported from a cell processing facility such as CPC to a medical institution or the like. FIG. 8 shows a process when the sample container is carried out from the cell processing facility, and FIG. 9 shows a process when the sample container is carried into the medical institution after transportation.

As shown in FIG. 8, the cells are cultured in a culture area in a cell processing facility such as CPC. The cleanliness of this room is generally set to Grade B, which is the second highest after Grade A. The sample container 104 at the time of culture is contained in a thermostatic bath, and is taken out as necessary, and operations such as medium exchange are performed in a safety cabinet. The cleanliness in the safety cabinet is generally set to grade A. A sample which has been cultured and shipped to a medical institution is packaged by a packaging container 100 in a safety cabinet. The packaging container is sterilized in advance and is in a sterile state. Thereby, when packaging is completed, the inside of the sample container and the inside and outside of the packaging container have the same level of cleanliness as Grade A.
In this state, the packaged sample container 104 is carried out of the cell processing facility. At this time, if necessary, it is accommodated in a transport container that maintains a constant temperature. As it is transported out of the cell processing facility from the culture area, the cleanliness in the transport environment decreases. Therefore, finally, organisms and particles such as bacteria adhere to the outside of the outermost packaging container 100. On the other hand, the inside of the packaging container 100 located on the outermost side, the sample container 104 and the like are in an unopened state, and therefore maintain the cleanliness of grade A.

FIG. 9 shows a process when transporting to a medical institution. After arriving at a medical institution, first, the state of the biological sample is evaluated. Based on the result of the evaluation, it is confirmed that it can be used for treatment.
At this time, the sample to be used for treatment must be a non-invasive evaluation method. This is because the quality of a biological sample changes in an invasive evaluation method. In addition, it is desirable that 100% inspection can be performed. Since cultured biological samples use the same cell source and have undergone the same manufacturing process, the quality after culturing is considered to be the same, but the quality of cells can be easily changed by slight environmental changes.
Therefore, in this example, the microscopic observation, which is the non-invasive evaluation method described above, is performed with the sample container being packaged.

  If it is determined that it can be used for treatment, preparation for treatment is started. Prepare the patient for treatment. Thereafter, the sample container 104 is transported to the operating room where the treatment is performed. The operating room generally has class 100 cleanliness. There are clean and unclean fields in the operating room. The sample container brought into the operating room is first disinfected with ethanol or the like. Then, in the unclean field, the packaging container 100 is opened. At this time, care should be taken so that the outside of the packaging container does not touch a clean sample. Then, an operator who is in charge of handling only clean field instruments takes out only the sample container 104. Finally, the same worker takes out the biological sample from the sample container in the clean field. Use it for treatment.

  Next, a series of procedures for carrying the cells into the cell processing facility such as the packaging container when the cells are transported using the packaging container having the above configuration will be described.

<Step S1: Preparation>
Make the necessary preparations to transport the cells. The packaging container is packaged in advance with an autoclave bag or the like, and sterilized in that state to be sterilized. The method of sterilization is autoclaving, ethylene oxide gas treatment, γ-ray irradiation, etc., and a method that does not change the properties of the packaging container by performing sterilization is selected. For example, if the material is polystyrene, γ-ray irradiation treatment is adopted.
If the heat storage material is a hydrocarbon C ₂₀ H ₄₂ , the heat storage material box is made of metal or heat-resistant polycarbonate, and the hydrocarbon C ₂₀ H ₄₂ is completely sealed. Encapsulate. Since the melting point of hydrocarbon C ₂₀ H ₄₂ is 344 ° C., it does not evaporate even if it is autoclaved (120 ° C.), and there is no effect on the temperature maintenance performance of the heat storage material box. After sterilization, in order to store heat in the heat storage material, put it in a thermostatic bath in a packaged state and leave it until the temperature is stabilized. For example, in the case of hydrocarbon C ₂₀ H ₄₂ having a melting point of 36.4 ° C., the temperature of the thermostatic bath is 37 ° C. when most of the outside temperature to be transported is 36.4 ° C. or less. This is because, during transport, the outside temperature is lower than the melting point of C ₂₀ H ₄₂ , so heat goes out of the cell transport container. Conversely, if most of the outside temperature to be transported is 36.4 ° C or higher, the temperature of the thermostatic bath shall be 36 ° C. This is because, during transport, the outside temperature is higher than the melting point of C ₂₀ H ₄₂ , so heat enters the cell transport container from the outside.
For monitoring devices that are not resistant to various types of sterilization, ethanol disinfection shall be performed.

<Step S2: Carrying into cell processing facility>
Carry the sterilized cell transport container and packaging container to the culture area in the cell treatment facility. When moving between rooms in a cell processing facility, it is necessary to pass through a pass box in order to maintain cleanliness of the room and prevent cross contamination. When passing through the pass box, each component is sterilized by spraying ethanol from the outside of the package, placed in the pass box, and removed from the door on the side of the moving room.
After arriving at the cell culture area, the equipment other than the packaging container is opened and removed aseptically so as not to touch the outside of the packaging. Since the temperature of the heat storage material box changes when exposed to room temperature, it is desirable to prepare a thermostatic chamber in the same room if possible and place it in the thermostatic chamber until use to prevent temperature changes.
The packaging container is sterilized by spraying with ethanol around the package and placed in a safety cabinet. Thereafter, the packaging container is removed aseptically so as not to touch the outside of the packaging.
It is assumed that ethanol is disinfected outside in advance for bringing in the monitoring device. It is desirable to carry out sterilization and sterilization when bringing equipment into the room where cells are treated. However, since sterilization cannot be performed on mechanical devices, only ethanol treatment is generally performed.

DESCRIPTION OF SYMBOLS 100 Packaging container 101 Packaging container cover part 102 Elastic member 103 Packaging container main-body part 104 Sample container 105 Second culture medium 106 Porous membrane 107 Medium holding part 108 First culture medium 110 Screw receiving part 111 Screw part 112 Channel 113 Medium supply part 114 Injection suction port 115 Guide 120 Biological sample 501 Gas permeable membrane 601 Insert type sample container 602 Insert type sample container container 603 Six well plate 604 Screw 701 Container main body 702 Container lid 703 Heat insulating material 704 Heat storage material box 705 Sample container storage part 706 Sample container 707 Monitoring device

Claims (12)

A packaging container comprising a packaging container main body portion that contains a sample container having a sample therein and is held at the bottom, and a packaging container lid portion that seals the packaging container main body portion,
The packaging container lid part is provided with a medium holding part that is partitioned by a porous film and holds the first medium,
By joining the packaging container body and the packaging container lid, the packaging container lid seals the sample container,
The medium holding section, when the sealing of the sample container according to prior Symbol packaging container lid, and a second medium in the interior of the sample container and the first culture medium of said medium holding portion is in contact via the porous membrane Is,
The porous container is a packaging container characterized in that a substance absorbed or discharged by cells contained in each of the first and second culture media can move in both directions.   The packaging container according to claim 1,
  A guide part for positioning the sample container formed at the bottom of the packaging container main body part, a culture medium supply part that communicates with the culture medium holding part via a flow path, and supplies a culture medium to the culture medium holding part; Have
The culture container is characterized in that the culture medium supply part protrudes from the packaging container lid part toward the bottom surface of the packaging container main body part and is formed around the guide part.   In the packaging container according to claim 1 or 2,
  At the time of sealing the sample container by the packaging container lid, the culture medium holding part protrudes toward the bottom surface of the packaging container main body part rather than the part in contact with the sample container in the packaging container lid part. A packaging container characterized by being. The packaging container according to claim 1,
The packaging container lid part has an injection suction port for injecting and suctioning a culture medium. The packaging container according to claim 1,
The packaging container, wherein the sample container bottom part and the packaging container body part bottom part are in pressure contact with each other by a pressing force of the packaging container lid part to the packaging container body part. The packaging container according to claim 1,
A packaging container comprising a screw part on an outer peripheral side surface of the packaging container main body part and a screw receiving part on an inner side surface of the packaging container lid part. The packaging container according to claim 1,
The packaging container, wherein the sample is a biological sample. The packaging container according to claim 1,
A packaging container, wherein an elastic member is provided in a contact portion of the packaging container lid with the sample container. The packaging container according to claim 1,
The packaging container, wherein the side wall of the sample container and the side wall of the packaging container main body are substantially the same height. The packaging container according to claim 1,
A packaging container, wherein a gas permeable membrane is formed on a part of the packaging container lid. The packaging container according to claim 1,
A packaging container, wherein the sample container comprises an insert type sample container and an insert type sample container. The packaging container according to claim 1,
A packaging container, wherein the sample container is a well plate.

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