JP5587395B2 - Ophthalmic surgical microscope with OCT system - Google Patents

Description

  The present invention includes a microscope main objective lens, an observation optical path that passes through the microscope main objective lens, and an OCT system for capturing an image of the object area. The OCT system guides the object area through the scan mirror structure. The present invention relates to an ophthalmic surgical microscope including an OCT scanning optical path.

  A surgical microscope of the kind mentioned at the beginning is known from US Pat. The surgical microscope includes an OCT system that generates a scanning optical path derived from short coherent laser radiation. The OCT system includes an analysis unit for evaluating the interference signal and includes a device for scanning the OCT scanning optical path with two scanning mirrors that can be adjusted about two axes of motion. . The OCT scanning optical path in the surgical microscope is input coupled to the illumination optical path of the surgical microscope via the beam splitting mirror, and is guided to the object region through the microscope main objective lens together with this.

The OCT system allows non-invasive display and measurement of tissue internal structures using optical coherence tomography. Optical coherence tomography is an optical image generation method that makes it possible in particular to generate cross-sectional or volume images of biological tissue with micrometer resolution. A corresponding OCT system includes a light source for light of coherence length l _c that is supplied to the sample and reference optical paths and is temporally incoherent and spatially coherent. The sample optical path is directed to the tissue to be examined. The OCT system superimposes the laser radiation bounced back to the sample optical path based on the scattering center in the tissue with the laser radiation originating from the reference optical path. An interference signal is generated by superposition. Based on this interference signal, the position of the scattering center for laser radiation in the examined tissue can be determined.

  Regarding the OCT system, the structural principles of “time domain OCT” and “Fourier domain OCT” are known.

  The structure of “time domain OCT” is described in Patent Document 2, for example, from column 5 line 40 to column 11 line 10 with reference to FIG. In such a system, the optical path length of the reference optical path is continuously changed by a reference mirror capable of high-speed movement. Light derived from the sample optical path and the reference optical path is superimposed on the photodetector. When the optical path lengths of the sample optical path and the reference optical path match, an interference signal is generated in the photodetector.

  “Fourier domain OCT” is described in Patent Document 3, for example. In order to measure the optical path length of the sample optical path, the light derived from the sample optical path is also superimposed on the light derived from the reference optical path. However, unlike “time domain OCT”, in order to measure the optical path length of the sample optical path, the light derived from the sample optical path and the reference optical path is not directly supplied to the detector, but is first measured by the spectrometer. Disassembled. Then, the spectral intensity of the superimposed signal derived from the sample optical path and the reference optical path thus generated is detected by the detector. Similarly, by evaluating the detector signal, the optical path length of the sample optical path can be determined.

European Patent No. 097611B1 US Pat. No. 5,321,501 International Publication No. 2006 / 10544A1 Pamphlet

  SUMMARY OF THE INVENTION An object of the present invention is to provide an ophthalmic surgical microscope having a compact configuration that can capture an OCT tomogram of a human eye and can guide an OCT scanning optical path to an OCT scanning plane without loss of intensity. It is.

  The problem is that an optical member is provided between the scan mirror structure and the microscope main objective lens to focus the light in the OCT scanning optical path emitted from the scan mirror structure and shift it to the optical path that passes through the microscope main objective lens. It is solved by an ophthalmic surgical microscope of the kind mentioned at the beginning.

  The above problems are also solved by an ophthalmic surgical microscope of the type described at the beginning, which is provided with an ophthalmoscope inspection loupe that can be turned inward and outward to enter and exit the observation and OCT scanning optical paths. Is done. The ophthalmoscope loupe allows the OCT scanning optical path to be focused on the bottom of the patient's eye, thereby scanning the fundus and simultaneously looking into the eyepiece through the optical observation optical path of the surgical microscope. To be able to see.

  In the development of the present invention, the optical member between the scan mirror structure and the microscope main objective is manufactured as a movable lens unit. In this way, various tomographic planes of the human eye can be scanned with OCT radiation.

  In the development of the present invention, the optical member is accommodated in a lens exchange device. In this way, rapid reciprocal switching between various scanning planes of OCT radiation in the object area is possible.

  In a development of the invention, the optical member is manufactured as a zoom system with variable focal length. In this way, the tomographic plane examined by the patient's eye can be changed steplessly by OCT radiation.

  In a development of the invention, means are provided for adjusting the focal length of the main objective lens. In this manner, various planes of the object region can be inspected using the ophthalmic surgical microscope, and at that time, it is not necessary to displace the surgical microscope.

  In a development of the invention, the scan mirror structure includes a first scan mirror for scanning the OCT scan path. In addition to this, a second scan mirror is preferably provided, in which case the first scan mirror can be moved about the first axis of rotation and the second scan mirror is the second scan mirror. The first and second rotation axes are offset laterally and are perpendicular to each other. In this way, the object region can be scanned with a mesh pattern extending perpendicular to each other.

  In a development of the invention, the OCT system includes an optical waveguide having a light exit area for the OCT scanning optical path, which is accompanied by means for moving. In this way, the OCT system can be adapted to use various wavelengths of OCT radiation.

  In a development example of the present invention, an ophthalmologic surgical microscope is provided with an ophthalmoscope inspection loupe capable of turning inward and outward so as to enter and exit the observation optical path and the OCT scanning optical path. The ophthalmoscope inspection loupe is preferably combined with a reduction lens, and the ophthalmoscope inspection loupe and the reduction lens can be turned inward and outward so as to enter and exit the OCT scanning optical path and the observation optical path. Located in the module. In this way, an ophthalmic surgical microscope can be used to examine not only the front area of the patient's eye but also the fundus thereof with OCT radiation.

  In a development of the invention, the OCT system of the ophthalmic surgical microscope provides a first OCT scanning beam having a first wavelength and a second wavelength having a second wavelength different from the first wavelength. Designed to provide two OCT scan rays. A corresponding first OCT system and a corresponding second OCT system are preferably provided which provide OCT scanning beams of different wavelengths. In this way, body tissues with different absorption characteristics for OCT radiation can be examined with excellent resolution.

  Advantageous embodiments of the invention are illustrated in the drawings and are described below.

An ophthalmic surgical microscope comprising an ophthalmoscopic examination attachment module and a first OCT system. 1. The ophthalmic surgical microscope of FIG. 1 with a second OCT system, wherein the ophthalmoscopic examination attachment module is pivoted inward to enter the observation optical path of the ophthalmic surgical microscope. It is sectional drawing of the microscope main objective lens along the III-III line | wire of FIG. FIG. 3 is an area of an ophthalmic surgical microscope equipped with first and second OCT systems. It is an intensity distribution of the OCT scanning light beam emitted from the optical waveguide of the OCT system in the surgical microscope. It is an intensity distribution of the OCT scanning light beam in the OCT scanning plane of the object region of the surgical microscope. Figure 2 is a modified embodiment of an OCT system for a surgical microscope. Figure 2 is a modified embodiment of an OCT system for a surgical microscope.

  The surgical microscope 100 of FIG. 1 has a microscope main objective lens 101 having an optical axis 102 and a focal plane 103. The stereoscopic observation optical path 105 of the binocular tube 106 passes through the microscope main objective lens 101.

  In order to illuminate the object region as the patient's eye 108, the surgical microscope 100 has an illumination module 120 as an illumination device. The illumination module 120 includes a first optical waveguide 121 that provides illumination light 122 from a light source not shown in detail. A field stop 124 whose position is adjustable is illuminated by illumination light 122 emitted from the optical waveguide 121. Illumination light emitted from the optical waveguide 121 is guided to the object region 108 through the microscope main objective lens 101 by the reflecting mirror 123 disposed on the opposite side of the microscope main objective lens 101 from the object.

  The ophthalmic surgical microscope 100 has a reduction lens 131 that can be turned inward and outward to enter and exit the stereoscopic observation optical path 105 of the surgical microscope 100 as indicated by double arrows 133 and 134. And an ophthalmoscope inspection attachment module 130 including an ophthalmoscope inspection loupe 132 are attached.

  The ophthalmic surgical microscope 100 is provided with a first OCT system 140. The ophthalmic surgical microscope further includes a second OCT system shown in FIG. These OCT systems make it possible to capture OCT images.

  The OCT system 140 shown in FIG. 1 includes a unit 141 for generating and analyzing an OCT scanning optical path 142. The unit 141 is incorporated in the surgical microscope 100. Alternatively, the unit can be placed on a corresponding tripod pole outside the surgical microscope 100. The unit 141 is connected to an optical waveguide 143 that provides an OCT scanning optical path 142.

  The OCT scanning optical path 142 emitted from the optical waveguide 143 is guided by the diverging optical path to the first scanning mirror 144 and the second scanning mirror 145 of the OCT scanning unit 146, and from there, the optical in the form of a condensing lens 147. It reaches the member and then passes through the microscope main objective 101. The OCT scan path 142 is focused on the front area of the patient's eye 108 at the OCT scan plane 160.

  The OCT light back-scattered from the object region in the form of the patient's eye 108 to the OCT scanning optical path returns to the unit 141 via the microscope main objective lens 101, the condenser lens 147, and the OCT scanning unit 146. Thus, OCT scanning light backscattered from the object area is interfered with by OCT radiation originating from the reference optical path. The interference signal is detected by a detector and evaluated by a computer unit which, based on this signal, calculates the optical distance between the OCT light scattering center in the object region and the light path length in the reference shunt. Calculate the path length difference.

  To adjust the OCT scan plane 160, the condenser lens 147 is provided with a position adjustment mechanism 148, which allows the condenser lens to be moved as indicated by the double arrow 149.

  The first OCT system 140 operates at a wavelength λ = 1310 nm. The second OCT system of the ophthalmic surgical microscope 100 is configured according to the first OCT system 140, but has an operating wavelength of λ = 800 nm. Of course, the OCT system can be designed for other operating wavelengths. The operating wavelength can be embodied in particular within the range of 600 nm <λ <1500 nm, preferably each depending on the application.

  FIG. 2 shows the microscope for ophthalmic surgery 100 of FIG. 1 with a second OCT system 150 configured and arranged according to the first OCT system 140.

  The same reference numerals as those in FIG. 1 are assigned to the same modules of the surgical microscope.

  The OCT system 150 includes a unit 151 for generating and analyzing the OCT scanning optical path 152 of the OCT system 150, and produces OCT scanning radiation 152 at the exit end of the optical waveguide 153. Similar to the OCT scanning radiation 142 of the OCT system 190 shown in FIG. 1, the OCT scanning radiation 152 is configured as a condenser lens 157 by an OCT scanning unit 156 including a first scanning mirror 154 and a second scanning mirror 155. The optical main member 101 is guided through the optical member.

  FIG. 2 shows the ophthalmic surgical microscope 100 in an operating mode in which the reduction lens 131 of the ophthalmoscopic examination attachment module 130 and the ophthalmoscopic examination loupe 132 are pivoted inward so as to enter the observation optical path 205 of the surgical microscope 100. ing. This allows examination of the fundus 190 of the patient's eye 108 by light that bounces off the fundus 190 and enters the observation light path of the surgical microscope and by OCT scanning light.

  The condensing lens 157 focuses the OCT scanning optical path and guides it to the microscope main objective lens 101. The OCT scanning radiation passes through the microscope main objective 101, reduction lens 131, and ophthalmoscope loupe 132, and enters the patient's eye 108 and is focused on the fundus 190 of the patient's eye 108 at the OCT scanning plane 170. .

  The OCT light back-scattered from the object region in the form of the patient's eye 108 to the OCT scanning optical path is generated and analyzed through the microscope main objective 101, the condenser lens 157, and the OCT scanning unit 156. Return to the unit 151 for Thus, the OCT scanning light backscattered from the object region is further interfered with OCT radiation originating from the reference optical path. As in the case of the OCT system 140, the interference signal is also detected by the detector in the OCT system 150 and evaluated by the calculation unit. Based on this signal, the calculation unit determines the scattering center of the OCT light in the object region and the reference shunt. An optical path length difference between the optical path length and the optical path length is calculated.

  The condenser lens 157 is provided with a position adjusting mechanism 157, which can move the condenser lens as indicated by a double arrow 159. In this way, the focal plane can also be adjusted for OCT scanning radiation originating from the OCT system 150.

  The optical path length of the OCT scanning optical path in the operation mode shown in FIG. 2 of the microscope for ophthalmic surgery 100 is longer than that in the operation mode shown in FIG. This requires adaptation of the optical path length in the reference optical path of the OCT system 150. For this purpose, a coupler 180 between the ophthalmoscope inspection loupe 132 and the OCT system 150 is provided, and when this coupler is rotated inward to enter the observation optical path and the OCT optical path, The optical path length of the reference optical path of the OCT system is expanded according to a certain value. This value is preferably kept adjustable. The fixed value is conveniently based on the average length of the patient's eyes.

  FIG. 3 is a cross-sectional view taken along line III-III in FIG. This drawing explains the transition of the stereoscopic observation optical paths 105 and 205 of the surgical microscope 100 of FIG. Two stereoscopic partial optical paths 105 and 205 are transmitted through the microscope main objective 101. The optical axis 102 of the microscope main objective is located at the center 310 thereof. The OCT scanning optical path 142 of the OCT system 140 in FIG. 1 is transmitted through the microscope main objective lens 101 in the region 301. In the region 302, the OCT scanning light path 152 of the OCT system 150 shown in FIG. 2 is transmitted therethrough, and in the region 303, the illumination light 122 is transmitted.

FIG. 4 shows the first OCT system 140 and the second OCT system 150 of the surgical microscope 100 shown in FIGS. However, the wavelength regions of the OCT scanning optical paths of both OCT systems 140 and 150 are different. That is, the first OCT system relies on OCT scanning radiation of wavelength λ ₁ = 1310 nm. The second OCT system 320 operates with OCT scanning radiation at a wavelength λ ₂ = 800 nm. The same reference numerals as in FIGS. 1 and 2 are used to represent the modules of the OCT systems 140 and 150 of FIG.

  The first scan mirrors 144, 154 and the second scan mirrors 145, 155 of the OCT system 140, 150 have two axes 405, 406, 407, 408 extending perpendicular to each other by actuators 401, 402, 403, 404. It is arranged so that it can rotate as a center. This makes it possible to scan the OCT scanning optical paths 142 and 152 in one plane independently of each other.

  The OCT scanning optical path 142 of the first OCT system 140 is guided to the microscope main objective lens 101 via the condenser lens 147. The OCT scanning optical path 152 of the second OCT system 150 passes through the microscope main objective lens 101 via the condenser lens 157.

を満たしており、このときＮＡ₁は光導波路の前面の開口数である。光導波路１２２のファイバコアの直径ｄは、５μｍ＜ｄ＜１０μｍの範囲内にあるのが好ましい。このパラメータ範囲内では、光導波路１４３はガウス形の波長モードで光を案内する。ＯＣＴ走査光線５０１は、胴部パラメータＷ₁と開口パラメータθ₁によって特徴づけられる、近似的にガウス形の放射断面形状で光導波路１４３から射出され、このとき次式が成り立つ。

したがって、ｄ₁＝１０μｍのファイバコア直径と波長λ₁＝１３１０ｎｍについては、光線発散を表す目安としてθ₁≒０．０８２７ｒａｄの開口角が得られる。 FIG. 5 shows the front area 502 of the optical waveguide 143 of FIG. The optical waveguide 143 acts as a monomode fiber for light with a wavelength λ ₁ = 1310 nm. The diameter d ₁ of the fiber core of the optical waveguide 143 is given by

Where NA ₁ is the numerical aperture of the front surface of the optical waveguide. The diameter d of the fiber core of the optical waveguide 122 is preferably in the range of 5 μm <d <10 μm. Within this parameter range, the optical waveguide 143 guides light in a Gaussian wavelength mode. The OCT scanning light beam 501 is emitted from the optical waveguide 143 in an approximately Gaussian radiation cross-sectional shape characterized by the body parameter W ₁ and the aperture parameter θ ₁ , and at this time, the following equation is established.

Therefore, for a fiber core diameter of d ₁ = 10 μm and a wavelength of λ ₁ = 1310 nm, an opening angle of θ ₁ ≈0.0827 rad is obtained as a guide representing the light divergence.

  The front surface 502 of the optical waveguide 143 is imaged on the OCT scanning plane through the microscope main objective lens via the scan mirrors 144 and 145 and the condenser lens 147 in the surgical microscope 100 shown in FIG.

ここでλ₁はＯＣＴ走査光線の波長である。ガウス光束６００の胴部パラメータＷ_1、Aと、図５に示す、光導波路１４３から射出されるIII５０１の胴部パラメータＷ₁との間には、次の関係が成り立つ：
Ｗ_1,A＝β₁Ｗ₁
ここでβ₁は、ＯＣＴ走査平面における図１の光導波路１４３の射出端部の上に述べた幾何学的結像の拡大パラメータないし縮小パラメータである。β₁は、図１の集光レンズ１４７の焦点距離ｆ₁₄₇および顕微鏡主対物レンズの焦点距離ｆ₂との間で、次の関係によって結びついている：
ｆ₂／ｆ₁₄₇＝β₁ FIG. 6 shows the transition of the intensity distribution of the OCT scanning light beam 501 perpendicular to the OCT scanning plane 601. In the OCT scanning plane 601, the intensity distribution of the OCT scanning radiation has a minimum narrow portion. Outside the range of the OCT scanning plane, the diameter of the OCT scanning optical path increases. Since the OCT scanning light beam 501 is emitted from the optical waveguide 143 in FIG. 5 in an approximately Gaussian radiation sectional shape, the condenser lens 147 and the microscope main objective lens 101 of the surgical microscope 100 in FIG. Therefore, a so-called Gaussian light beam 600 of the OCT scanning light beam 501 is caused in the region of the OCT scanning plane 160. This Gaussian light beam 600 is used as a standard representing the diameter of the smallest narrow part 602 of the OCT scanning light beam 501 in the OCT scanning plane by the confocal parameter z ₁ as a standard representing the longitudinal length of the trunk of the Gaussian light beam. Of the body parameter W _{1, A} as a measure of the diameter of the body, where the following equation holds:

Here, λ ₁ is the wavelength of the OCT scanning beam. And the body parameter W _{1, A} Gaussian beam 600, shown in FIG. 5, between the body part parameters W ₁ of III501 emitted from the optical waveguide 143, the following relationship holds:
W _{1, A} = β ₁ W ₁
Here, β ₁ is an enlargement parameter or reduction parameter of the geometric imaging described above the exit end of the optical waveguide 143 in FIG. 1 in the OCT scanning plane. beta ₁ is between the focal length f ₂ of the focal length f ₁₄₇ and the microscope main objective of the condenser lens 147 of FIG. 1, are linked by the following relationship:
f ₂ / f ₁₄₇ = β ₁

The size of the structure that can be resolved by the OCT scanning beam 501 is determined by its diameter in the OCT scanning plane 601, that is, by the body parameter W ₁ . For example, if an application requires a lateral resolution of about 40 μm for an OCT system in a surgical microscope, according to Nyquist theorem, the cross-sectional area of the OCT scanning beam 501 in the OCT scanning plane must be about 20 μm. Accordingly, when the wavelength of the OCT scanning beam 501 shown in FIG. 1 is λ ₁ , the optical imaging magnification in the OCT optical path and the diameter of the fiber core of the optical waveguide 143 are required for the desired resolution of the OCT system 140. Must be selected appropriately.

The confocal parameter z ₁ as a guide representing the longitudinal length of the trunk of the Gaussian beam determines an axial depth region in which light backscattered in the OCT scanning optical path 143 of FIG. 1 can be detected. That is, the smaller the confocal parameter z _{1, the} greater the loss of the OCT system related to lateral resolution at the distance from the object scanned with OCT scanning radiation to the OCT scanning plane 601. This is because the location of the scattering center can be specified only within the “funnel” determined by the body parameter W ₁ and the confocal parameter z ₁ .

On the one hand, the axial resolution of the OCT system is limited by the light coherence length l _c of the light source used in the OCT system, and on the other hand, the lateral resolution of the OCT system has its depth stroke exceeding the confocal parameter. Therefore, it is advantageous to adjust the confocal parameter z ₁ according to the coherence length l _{c of the} light source used in the OCT system.

Then, for a specific wavelength λ ₁ of the OCT scanning beam 501, the possible lateral resolution of the OCT system of FIG. 1 is obtained. This is because the wavelength λ ₁ and the Rayleigh parameter z ₁ define the body parameters W _{1 and A.} Then, the dimension setting of the optical system unit of the OCT scanning optical path 143 and the fiber core of the optical waveguide 143 shown in FIG. 1 can be selected so that the corresponding body parameters are embodied.

  The condensing lens 147 of the surgical microscope 100 is preferably adjusted so that the focal plane 170 of the microscope main objective 101 for the visible spectral region and the OCT scanning plane 160 of the OCT system 140 coincide. Then, the body portion 502 of the OCT scanning beam shown in FIG. 5 is located on the focal plane of the surgical microscope.

を満たしており、このときＮＡ₂は光導波路１５３の前面の開口数である。ＯＣＴ走査光線１５２は、胴部パラメータＷ₂と開口パラメータθ₂によって特徴づけられる、同じく近似的にガウス形の放射断面形状で光導波路１５３から射出され、このとき次式が成り立つ。

With respect to the OCT scanning optical path 152 of the OCT 150 shown in FIG. 2, the optical waveguide 153 acts as a monomode fiber for light having a wavelength λ ₂ = 800 nm. The diameter d ₂ of the fiber core of the optical waveguide 153 is given by

In this case, NA ₂ is the numerical aperture of the front surface of the optical waveguide 153. The OCT scanning light beam 152 is emitted from the optical waveguide 153 with the same Gaussian radiation cross-sectional shape, which is characterized by the body parameter W ₂ and the aperture parameter θ ₂ , and at this time, the following equation is established.

Thus, for the body parameter of the OCT scan ray 152 at the OCT scan plane 170, the following equation holds:
W _{2, A} = β ₂ W ₂
Here, β ₂ is an enlargement parameter or reduction parameter of geometrical imaging at the exit end of the optical waveguide 153 in FIG. 2 in the OCT scanning plane 170.

β ₂ is determined by the focal length of the condenser lens 157 in FIG. 2, the focal length of the microscope main objective lens 101, and the cornea and lens of the reduction lens 131, the ophthalmoscope loupe 132, and the patient's eye 108.

  At this time, when the optical observation optical path forms an image of the fundus 190 of the patient's eye 108 with the microscope main objective lens 101, the condenser lens 157 causes the OCT scanning plane 170 of the OCT system 150 in the surgical microscope 100 to It is preferably adjusted to match 190.

  Instead of the above-described design of the OCT system in the surgical microscope, an offset between the OCT scanning plane and the focal plane of the surgical microscope may be intended. Such an offset is preferably not larger than the confocal parameter z of the OCT scanning beam in the region of the OCT scanning plane.

  By moving the OCT scanning plane further away from the microscope main objective 101 of FIG. 1 by the confocal parameter z, the depth stroke of the OCT system in the object region can be maximized.

  FIG. 7 shows a modified embodiment of an OCT system that can be used with the ophthalmic surgical microscope 100 shown in FIGS. 1 and 2.

  The OCT system 700 includes a unit 701 for generating and analyzing an OCT scanning optical path 702 according to the OCT system 140 shown in FIG. This unit 701 is designed to be able to generate and evaluate OCT scanning optical paths of different wavelengths. A control device 703 is provided for adjusting the wavelength of the OCT system 700.

  The OCT scanning optical path 702 is emitted from the optical waveguide 704 connected to the unit 701 and reaches the two scanning mirrors 705 and 706. These mirrors are movable by a driving device not shown in detail so that the object region 708 can be scanned by the OCT scanning plane 707.

  In order to set various OCT scanning planes, the OCT system 700 is provided with a magnification changing device 709 as a lens exchange device including condensing lenses 710 and 711 having different refractive powers. These condenser lenses 710 and 711 can turn inward and outward so as to enter and exit the OCT scanning optical path 702. In addition, a drive unit 712 is attached to the light guide 704, which allows the exit end 713 of the light guide to move as indicated by the double arrow 714, and thus in the object region. The position of the OCT scanning plane 707 can be changed.

  The OCT scanning optical path 707 reaches the OCT scanning plane through a condensing lens 709 that focuses the scanning optical path and further guides it to the microscope main objective of the corresponding surgical microscope.

  FIG. 8 shows yet another embodiment of an OCT system for an ophthalmic surgical microscope. Similar to the OCT system 700, the OCT system includes a unit 801 for generating and analyzing an OCT scanning optical path 802 emitted from the optical waveguide 803. In the OCT system 800, the OCT scanning optical path 802 emitted from the exit end 804 of the optical waveguide passes through a lens unit 806 with adjustable refractive power, which acts as a zoom system, via a corresponding scan mirror system 805. Be guided to. In this way, it is also possible to change the position of the OCT scanning plane 807 in the object area 808.

  Yet another modified embodiment of the surgical microscope 100 described with reference to FIG. 1 includes a focusable microscope main objective that is adjustable in focal length. This measure also allows displacement of the OCT scan plane and changes the geometric imaging of the exit end of the optical waveguide onto the OCT scan plane.

  DESCRIPTION OF SYMBOLS 100 Ophthalmic surgery microscope, 101 Microscope main objective lens, 105 Observation optical path, 108 Object area | region, 132 Ophthalmoscope inspection loupe, 140 OCT system, 142 OCT scanning optical path, 146 Scan mirror structure, 147 Optical member

<Appendix 1>
A microscope main objective (101);
An observation optical path (105, 205) that passes through the microscope main objective (101) to visualize the object region (108);
And an OCT system (140, 150, 700, 800) for capturing an image of the object region (108). The OCT system (140, 150, 700, 800) includes a scan mirror structure (146, 156, 705). An ophthalmic surgical microscope (100) including an OCT scanning optical path (142, 152, 702, 802) guided to an object region (108) via 706, 805),
The OCT emitted from the scan mirror structure (146, 156, 705, 706, 805) between the scan mirror structure (146, 156, 705, 706, 805) and the microscope main objective lens (101) Optical members (147, 157, 711, 806) for converging the scanning optical path (142, 152, 702, 802) and shifting to the optical path that transmits the microscope main objective lens (101) are provided. A microscope for ophthalmic surgery.
<Appendix 2>
The microscope for ophthalmic surgery according to appendix 1, wherein the optical member is configured as a movable lens unit (147, 157).
<Appendix 3>
The microscope for ophthalmic surgery according to appendix 1 or 2, wherein the optical member (711) is accommodated in a lens exchange device (709).
<Appendix 4>
The microscope for ophthalmic surgery according to claim 1, wherein the optical member is configured as a zoom system (806) having a variable focal length.
<Appendix 5>
The microscope for ophthalmic surgery according to any one of appendices 1 to 4, wherein means for adjusting a focal length of the microscope main objective lens is provided.
<Appendix 6>
The scan mirror structure (146, 156) includes a first scan mirror (144, 154) that can move about a first rotation axis (301, 303) to scan the OCT scanning optical path. The microscope for ophthalmic surgery according to any one of appendices 1 to 5, characterized in that:
<Appendix 7>
A second scan mirror (145, 155) that can be moved around the second rotation axis (302, 304) is provided, and the first rotation axis (301, 303) and the second rotation are provided. The microscope for ophthalmic surgery according to appendix 6, wherein the axes (302, 304) are offset laterally and are perpendicular to each other.
<Appendix 8>
The OCT system includes a light guide (704) having a light exit area (713) for the OCT scanning optical path, and means (712) for moving the light exit area (713) of the light guide (704). The microscope for ophthalmic surgery according to any one of appendices 1 to 7, characterized in that:
<Appendix 9>
A microscope main objective (101);
An observation optical path (105, 205) that passes through the microscope main objective (101) to visualize the object region (108);
And an OCT system (140, 150, 700, 800) for capturing an image of the object region (108). The OCT system (140, 150, 700, 800) includes a scan mirror structure (146, 156, 705). 706, 805) through the OCT scanning optical path (142, 152, 702, 802) guided to the object area (108).
In the microscope for ophthalmic surgery according to any one of appendices 1 to 8,
An ophthalmologic surgical microscope characterized in that an ophthalmoscopic examination loupe (132) capable of turning inward and outward to enter and exit the observation optical path and the OCT scanning optical path is provided.
<Appendix 10>
The OCT system 140 and the ophthalmoscope inspection loupe (132) are arranged so that the optical path length of the reference optical path of the OCT system is enlarged by a certain value when the ophthalmoscope inspection loupe (132) turns inward. The microscope for ophthalmic surgery according to appendix 9, wherein a coupler is provided.
<Appendix 11>
Any one of Supplementary notes 1 to 10, further comprising a reduction lens (131) that can turn inward and outward to enter and exit the observation optical path and the OCT scanning optical path (142). The microscope for ophthalmic surgery according to claim 1.
<Appendix 12>
An ophthalmoscope examination attachment comprising the ophthalmoscope examination loupe (132) and / or the reduction lens (131) that can be turned inward and outward to enter and exit the OCT scanning optical path (142, 152). The microscope for ophthalmic surgery according to any one of supplementary notes 1 to 11, wherein a module (130) is provided.
<Appendix 13>
The OCT system (700) is designed to provide an OCT scanning beam having various wavelengths λ 1 and a second wavelength λ 2 different from the wavelength λ 1. The microscope for ophthalmic surgery according to claim 1.
<Appendix 14>
Appendices 1 to 13 characterized in that a first OCT system (140) and a second OCT system (150) are provided which provide OCT scanning rays (142, 152) of different wavelengths λ1, λ2. The microscope for ophthalmic surgery according to any one of the above.

Claims (9)

A microscope main objective (101);
An observation optical path (105, 205) that passes through the microscope main objective (101) to visualize the object region (108);
An OCT system (140, 150, 700, 800) for capturing an image of an object region (108), said OCT system via the scan mirror structure (146, 156, 705, 706, 805) Said OCT system (140, 150, 700, 800) comprising an OCT scanning light path (142, 152, 702, 802) guided to the object region (108);
The OCT emitted from the scan mirror structure (146, 156, 705, 706, 805) between the scan mirror structure (146, 156, 705, 706, 805) and the microscope main objective lens (101) Optical members (147, 157, 711, 806) for converging only the scanning optical path (142, 152, 702, 802) and shifting to the optical path transmitting the microscope main objective lens (101);
An ophthalmic surgical microscope (100) comprising:
The optical member is configured as a lens unit (147, 157) movable toward or away from the microscope main objective lens (101) , thereby offsetting the OCT scanning plane to the focal plane of the surgical microscope The microscope for ophthalmic surgery is characterized in that the OCT scanning optical path has a body portion with a minimum intensity distribution on the OCT scanning plane.   The microscope for ophthalmic surgery according to claim 1, further comprising a lens exchange device (709), wherein the optical member is accommodated in the lens exchange device (709).   The ophthalmic surgical microscope according to claim 1, wherein the optical member is a zoom system (806) having a variable focal length.   The ophthalmic surgical microscope according to any one of claims 1 to 3, wherein the offset is not larger than a confocal parameter (z) of the OCT scanning optical path in a region of the OCT scanning plane.   The scan mirror structure (146, 156) for scanning the OCT scanning optical path includes a first scan mirror (144, 154) that can move around a first rotation axis (301, 303). The microscope for ophthalmic surgery according to any one of claims 1 to 4, wherein the microscope is used for ophthalmic surgery.   The scan mirror structure (146, 156) includes a second scan mirror (145, 155) that can be moved around a second rotation axis (302, 304), and the first rotation axis (301, 156). The microscope for ophthalmic surgery according to claim 5, wherein 303) and the second rotation axis (302, 304) are offset laterally to form a right angle with each other.   The OCT system includes a light guide (704) having a light exit area (713) for the OCT scanning optical path, and means (712) for moving the light exit area (713) of the light guide (704). The microscope for ophthalmic surgery according to any one of claims 1 to 6, characterized in that   8. An ophthalmoscope inspection loupe (132) capable of turning inward and outward to enter and exit the observation optical path and the OCT scanning optical path is provided. The microscope for ophthalmic surgery according to claim 1. The microscope for ophthalmic surgery according to claim 8 , further comprising a reduction lens (131) capable of turning inward and outward to enter and exit the OCT scanning optical path and the observation optical path. .

Images