JP5376531B2 - Guide wire - Google Patents

Description

  The present invention relates to a guide wire.

  Conventionally, various guide wires have been proposed which are used to guide a medical device or the like to a target site by being inserted into a tubular organ such as a blood vessel, a digestive tract, or a ureter or a body tissue.

  For example, the guide wire described in Patent Document 1 includes a distal end portion and an intermediate portion adjacent to the proximal end direction of the distal end portion, and the intermediate portion is characterized by having lower lubricity than the distal end portion. This improves the insertion property of the catheter and the fixation property of the catheter and the guide wire by the intermediate portion.

  The guide wire described in Patent Document 2 includes a core wire and a coil spring, and the coil spring includes a distal end side small diameter portion, a rear end side large diameter portion having a larger outer diameter than the distal end side small diameter portion, and a distal end side. A taper portion positioned between the small diameter portion and the rear end side large diameter portion, the inside of the coil spring is filled with resin, and a hydrophilic resin layer is formed on the surface of the coil spring. Thus, the insertion property of the guide wire is improved.

US Pat. No. 5,924,998 Japanese Patent No. 4354525

  However, although the guide wire described in Patent Document 1 achieves both insertability by the distal end and fixation of the catheter and the guide wire by the intermediate portion, the distal end of the guide wire is strongly in the stenotic lesion. When inserted, even if the lubricity of the intermediate part is lower than that of the terminal part, the outer diameter of the terminal part and the intermediate part of the guide wire is the same, so the fixing property at the intermediate part is not good. The distal end of the guide wire may inadvertently enter the peripheral blood vessel on the distal side of the stenosis, and may puncture the peripheral blood vessel or damage the blood vessel wall in the peripheral blood vessel. It was.

  In addition, the guide wire described in the cited document 2 has improved insertability due to the small diameter portion on the distal end side, but when the distal end of the guide wire is strongly inserted into the stenotic lesion, Similar to the guide wire described in Document 1, the distal end portion of the guide wire unintentionally invades into the peripheral blood vessel on the peripheral side of the stenosis, and the peripheral blood vessel is pierced, There was a risk of damaging the blood vessel wall.

  The present invention has been made in view of such problems, and by reducing the outer diameter of the distal end portion of the guide wire to improve the insertability of the guide wire into the stenotic lesion, the tapered portion has a friction resistance portion. By providing a temporary stopper function to the guide wire, preventing unintentional insertion of the stenosis into the peripheral blood vessel in the more peripheral direction, preventing peripheral blood vessel perforation and damage to the blood vessel wall An object of the present invention is to provide a guide wire with improved guide wire safety.

  <1> The invention according to claim 1 includes a core shaft and a coil body that covers the core shaft, and the coil body includes a small diameter portion, a large diameter portion, the small diameter portion, and the thick diameter. A first taper portion positioned between the diameter portion, and at least a part of the first taper portion is provided with a friction resistance portion having a higher friction resistance than the small diameter portion, Features a guide wire.

<2> The invention according to claim 2 is the guidewire according to claim 1,
The narrow-diameter portion has a second taper portion in which the outer diameter of the coil decreases in the distal direction, and the angle of the second taper portion with respect to the major axis direction is relative to the major axis direction of the first taper portion. Features a guide wire that is smaller than the angle.

  <3> The invention according to claim 3 is the guide wire according to claim 1 or 2, wherein a lubricous film is formed at a position spaced apart from the first tapered portion of the small diameter portion. Features a guide wire.

  <4> The invention according to claim 4 is the guide wire according to any one of claims 1 to 3, wherein the frictional resistance portion is a concavo-convex portion provided on a surface of a wire forming a coil body. Characterized by a guide wire formed by

  <5> The invention according to claim 5 is the guide wire according to any one of claims 1 to 4, wherein the tip of the frictional resistance portion is located at the tip of the first tapered portion. Features a guide wire.

  <6> The invention according to claim 6 is the guide wire according to any one of claims 1 to 5, wherein a part of the first taper portion provided with the frictional resistance portion and the core are provided. The shaft is characterized by a guide wire that is secured to each other by a securing portion.

  <7> The invention according to claim 7 is the guide wire according to claim 6, wherein the tip of the friction resistance portion is located at the tip of the first taper portion, and the fixing portion is the first taper portion. A guide wire located at the tip of the.

  <1> In the guide wire according to claim 1, since the coil body has the small-diameter portion, the friction resistance portion is provided in the first taper portion while improving the insertability of the guide wire into the narrowed portion. When the guide wire comes into contact with the stenosis, the friction resistance part functions as a temporary stopper to prevent unintentional entry into the peripheral blood vessel in the peripheral direction from the stenosis, It is effective in preventing damage to the blood vessel wall and improving the safety of the guide wire.

  <2> The guide wire according to claim 2 has a second tapered portion in which the outer diameter of the coil decreases in the distal direction in the small diameter portion, and an angle of the second tapered portion with respect to the major axis direction. However, since the angle with respect to the major axis direction of the first taper part is smaller, the insertion function of the guide wire to the constriction part by the second taper part is further improved while ensuring the stopper function by the friction resistance part of the first taper part. Has the effect of making

  <3> The guide wire according to claim 3 has a lubricating film formed at a position spaced from the first taper portion of the small diameter portion, so that a stopper function is ensured by the friction resistance portion of the first taper portion. However, there is an effect that the insertability of the guide wire into the narrowed portion is greatly improved.

  <4> In the guide wire according to claim 4, since the frictional resistance portion is formed by unevenness provided on the surface of the wire forming the coil body, the frictional resistance portion can be easily configured. Further, since physical friction can be applied between the friction resistance portion and the constriction portion, the stopper function by the friction resistance portion of the first taper portion is further improved, and thus the safety of the guide wire. There is an effect of further improving.

  <5> The guide wire according to claim 5, wherein the tip of the friction resistance portion is located at the tip of the first taper portion, and the tip of the first taper portion where the outer diameter of the coil starts to expand is the friction resistance portion. Since the contact with the narrowed portion, the stopper function by the frictional resistance portion of the first taper portion is further improved, and the safety of the guide wire is further improved.

  <6> In the guide wire according to claim 6, since the first taper portion provided with the friction resistance portion and the core shaft are fixed to each other at the fixing portion, the friction resistance portion comes into contact with the narrowed portion. However, since the deformation of the first taper portion having the friction resistance portion can be prevented, the stopper function by the friction resistance portion of the first taper portion is further improved, and further, the safety of the guide wire is further improved. There is an effect.

  <7> In the guide wire according to the seventh aspect, since the fixing portion and the tip of the frictional resistance portion are provided at the tip of the first taper portion, it is possible to reliably prevent the tip of the first taper portion from being deformed. Thus, the stopper function by the frictional resistance portion of the first taper portion is greatly improved, and as a result, the safety of the guide wire is greatly improved.

1 is an overall view of a guide wire showing a first embodiment of the present invention. It is a block diagram of the guide wire which shows 2nd Embodiment of this invention, (a) is a general view of a guide wire, (b) is the elements on larger scale of a guide wire. It is a general view of the guide wire which shows 3rd Embodiment of this invention. It is a general view of the guide wire which shows 4th Embodiment of this invention. It is a block diagram of the guide wire which shows 5th Embodiment of this invention, (a) is a general view of a guide wire, (b) is the elements on larger scale of a guide wire. It is a general view of the guide wire which shows 6th Embodiment of this invention.

  Hereinafter, a guide wire of the present invention will be described based on a preferred embodiment shown in the drawings.

<First Embodiment>
FIG. 1 is an overall view showing a guide wire according to a first embodiment of the present invention.

In FIG. 1, for convenience of explanation, the left side is described as “base end” and the right side is described as “tip”.
Moreover, in FIG. 1, since the length direction of the guide wire 1 is shortened and schematically shown as a whole for easy understanding, the overall dimensions are different from actual ones.

  In FIG. 1, the guide wire 1 includes a core shaft 2 and a coil body 3 that covers the tip of the core shaft 2.

  The core shaft 2 includes a large-diameter portion 2a, a tapered portion 2b that is located at the distal end of the large-diameter portion 2a and whose outer diameter decreases in the distal direction, and a small-diameter portion that is located at the distal end of the tapered portion 2b. 2c.

  The coil body 3 includes a large-diameter portion 3a, a small-diameter portion 3c positioned in the distal direction of the large-diameter portion 3a, and a first tapered portion 3b positioned between the large-diameter portion 3a and the small-diameter portion 3c. have.

The proximal end of the large diameter portion 3a of the coil body 3 and the distal end of the large diameter portion 2a of the core shaft 2 are fixed by brazing 9, and the distal end of the small diameter portion 3c of the coil body 3 and the core shaft are fixed. The tip of the two small diameter portions 2 c is fixed by the most distal end portion 6.
Further, the distal end portion of the large diameter portion 3 a of the coil body 3 and the intermediate portion of the small diameter portion 3 c of the coil body 3 are fixed to the small diameter portion 2 c of the core shaft 2 via the fixing portion 7.

  Furthermore, a part of the first tapered portion 3 b of the coil body 3 is provided with a friction resistance portion 4 having a higher friction resistance than that of the small diameter portion 3 c of the coil body 3.

  Thus, since the coil body 3 has the small diameter part 3c, the guide wire 1 can improve the insertability of the guide wire 1 with respect to a constriction part. Further, since the frictional resistance portion 4 is provided in the first taper portion 3b of the coil body 3, when inserting the guide wire 1 into the stenotic lesion, the operator mistakenly inserts the guide wire 1 into the stenosis portion vigorously. Even if it does, the frictional resistance part 4 provided in the 1st taper part 3b of the coil body 3 will contact a constriction part, and will function as a temporary stopper. As a result, the guide wire 1 has a function of preventing unintentional invasion into the peripheral blood vessels in the peripheral direction further than the stenosis portion, so that it is possible to prevent peripheral blood vessel perforation and damage to the blood vessel wall. Can be improved.

  In addition, since the distal end side of the large diameter portion 3a of the coil body 3 and the intermediate portion of the small diameter portion 3c of the coil body 3 are fixed to the small diameter portion 2c of the core shaft 2 via the fixing portion 7, the coil When the first tapered portion 3b of the body 3 comes into contact with the constricted portion, the first tapered portion 3b of the coil body 3 provided with the frictional resistance portion 4 is hardly deformed. As a result, since the frictional resistance part 4 comes into firm contact with the lesioned part, the stopper function of the guide wire 1 by the frictional resistance part 4 can be improved.

The guide wire 1 of this embodiment can be produced by the following method.
First, a core bar is prepared to configure the coil body 3. Since this core metal has a large diameter part, a small diameter part, and a taper part located between this large diameter part and the small diameter part, the strand of the coil body 3 is attached to this core metal. The coil body 3 can be manufactured by winding and then pulling out the cored bar.
In addition, after winding the strand of the coil body 3 around a core metal, in order to maintain the shape of the coil body 3, heat treatment was performed, and the stress generated when the strand of the coil body 3 was wound around the core metal May be relaxed.

  Next, a large diameter portion 2a, a tapered portion 2b, and a small diameter portion 2c are formed on the core shaft 2 using a centerless polishing machine or the like, and the tip of the small diameter portion 2c of the core shaft 2 is connected to the large diameter portion of the coil body 3. The proximal end of the large-diameter portion 3 a of the coil body 3 and the distal end of the large-diameter portion 2 a of the core shaft 2 are fixed by brazing 9.

  Next, the tip end of the small diameter portion 3 c of the coil body 3 and the tip end of the small diameter portion 2 c of the core shaft 2 are fixed at the most distal end portion 6.

  Finally, the distal end portion of the large diameter portion 3a of the coil body 3 and the intermediate portion of the small diameter portion 3c of the coil body 3 are fixed to the small diameter portion 2c of the core shaft 2 via the fixing portion 7, respectively. Thus, the guide wire 1 can be manufactured.

  Note that when forming the fixing portion 7 for fixing the coil body 3 and the core shaft 2, the most distal portion 6, and the brazing 9, although not shown, the element of the coil body 3 corresponding to this forming portion is not shown. A gap may be provided between the strands of the wires so that the coil body 3 and the core shaft 2 can be easily fixed.

  When the frictional resistance portion 4 is provided on the first taper portion 3b of the coil body 3, after forming the coil body 3 or after forming the guide wire 1, a part or the whole of the first taper portion 3b of the coil body 3 is formed. In addition, a treatment for increasing the frictional resistance with the blood vessel may be performed. For example, a solution is prepared by dissolving a rubber component or an elastomer component in a solvent, and the solution is applied to the first tapered portion 3b of the coil body 3, or rubber is applied to the outer peripheral surface of the first tapered portion 3b of the coil body 3. An elastomer component is melted by a molding method in which a rubber component or an elastomer component is melted by heating with a mold or a heat-shrinkable tube or a first taper portion 3b of the coil body 3 is extruded. By adopting the method of providing the body, the friction resistance portion 4 can be provided on the first tapered portion 3 b of the coil body 3.

  Further, the method for increasing the frictional resistance with the blood vessel is not limited to this, and other methods may be used, or the method of roughening the surface roughness of the first tapered portion 3b of the coil body 3 may be used. .

Next, the material which comprises the guide wire 1 of 1st Example is described below.
The rubber component and the elastomer component that form the friction resistance portion 4 are not particularly limited, but silicon rubber, acrylic rubber, nitrile rubber, isoprene rubber, styrene butadiene rubber, epichlorohydrin rubber, etc. are used as the rubber component. Moreover, a styrene-type elastomer, an olefin type, a polyurethane type, a polyester type, a polyamide type, etc. can be used as an elastomer component. Moreover, you may use the polymer alloy which mixed the rubber component and the elastomer component.

  Further, when the friction resistance portion 4 is formed of a rubber component or an elastomer component, the first taper portion 3b of the coil body 3 is subjected to surface modification by plasma treatment or primer treatment, so that the friction resistance portion 4 and the coil body are formed. The fixing strength with the first taper portion 3b may be increased. By doing in this way, peeling of the friction resistance part 4 from the 1st taper part 3b of the coil body 3 can be prevented, and the fall of the stopper function of the guide wire 1 can be prevented.

  The material for forming the core shaft 2 is not particularly limited. For example, a material such as a stainless steel (SUS304), a superelastic alloy such as a Ni-Ti alloy, or a piano wire can be used. .

Moreover, as a material which forms the coil body 3, the strand which has radiopacity, or the strand which has radiation transparency can be used.
The material of the wire having radiopacity is not particularly limited. For example, gold, platinum, tungsten, or an alloy containing these elements (for example, platinum-nickel alloy) is used. Can do.
Further, the material of the wire having radiation transparency is not particularly limited, but for example, stainless steel (SUS304, SUS316, etc.), super elastic alloy such as Ni-Ti alloy, piano wire, or the like is used. be able to.

Moreover, you may form the coil body 3 from a radiopaque strand and a radiation transparent strand. In this case, the small diameter portion 3c, the first taper portion 3b, and the distal end portion of the large diameter portion 3a are formed of a radiopaque element wire such as a platinum-nickel alloy, and the coil body 3 It is preferable to form the base end side from the front-end | tip part of the large diameter part 3a with a radiolucent strand like stainless steel.
This improves the visibility under radioscopy from the distal end of the small diameter portion 3c of the coil body 3 to the distal end portion of the large diameter portion 3a including the first tapered portion 3b. By operating, when the narrow diameter portion 3c and the first tapered portion 3b of the coil body 3 collide with the narrowed portion, the position of the narrowed portion and the position of the guide wire 1 can be grasped. As a result, since the subsequent operation of the guide wire 1 can be performed carefully, it is possible to prevent peripheral blood vessel perforation and damage to the peripheral blood vessel wall from the stenosis portion by the guide wire 1. Safety can be improved.

  As described above, the small diameter portion 3c of the coil body 3, the first taper portion 3b, and the distal end portion of the large diameter portion 3a are formed of radiopaque strands, and the large diameter portion 3a of the coil body 3 is formed. When the base end side of the distal end portion is formed of a radiolucent strand, the coil body 3 is configured to weld the base end of the radiopaque strand and the distal end of the radiolucent strand. Alternatively, the base end of the radiopaque element wire and the radiolucent tip are fixed through a fixing portion 7 to which the large diameter portion 3a of the coil body 3 and the small diameter portion 2c of the core shaft 2 are fixed. It can be manufactured by bonding.

  Brazing 9 for fixing the distal end of the large diameter portion 2a of the core shaft 2 and the proximal end of the large diameter portion 3a of the coil body 3, the thin diameter portion 2c of the core shaft 2, the large diameter portion 3a of the coil body 3, and the small diameter The material of the fixing portion 7 that fixes the portion 3c and the tip portion 6 that fixes the tip of the small diameter portion 2c of the core shaft 2 and the tip of the small diameter portion 3c of the coil body 3 are particularly limited. Although not, for example, metal solder such as aluminum alloy brazing, silver brazing, gold brazing, zinc, Sn-Pb alloy, Pb-Ag alloy, Sn-Ag, Au-Sn alloy, polyethylene, polypropylene, polyamide, various elastomers A synthetic resin such as a material or an adhesive such as an epoxy resin can be used.

  Moreover, when assembling each part using a metal solder, it is preferable to apply a flux in advance to the position where the fixing is performed. Thereby, the wettability between the metal solder and each component becomes good, and the fixing strength increases.

Second Embodiment
Next, the guide wire 11 according to the second embodiment will be described with reference to FIGS. 2A and 2B, focusing on differences from the first embodiment. Portions common to the first embodiment are denoted by the same reference numerals in the drawing.
In FIG. 2 (a), the length of the guide wire 11 is shortened and the entire guide wire 11 is schematically shown for easy understanding, so the overall dimensions are different from the actual dimensions. . FIG. 2B is a partially enlarged view of the distal end portion of the guide wire 11. Like FIG. 2A, the size of the drawing is different from the actual size.

  In FIG. 2A, the guide wire 11 is composed of a core shaft 2 and a coil body 13 that covers the tip of the core shaft 2.

The coil body 13 includes a large diameter portion 13a, a small diameter portion 13c, and a first tapered portion 13b positioned between the large diameter portion 13a and the small diameter portion 13c. A second taper portion in which the outer diameter of the coil decreases in the distal direction over the entire length of the portion 13c.
Further, the frictional resistance portion 4 is provided on the first taper portion 13 b of the coil body 13.
Further, the small diameter portion 2 c of the core shaft 2 and the intermediate portion of the first tapered portion 13 b and the intermediate portion of the small diameter portion 13 c of the coil body 13 are fixed by the fixing portion 7.

  In addition, as shown in FIG. 2B, the first taper portion 13 b of the coil body 13 is in parallel with the center line CL of the guide wire 1 in the long axis direction of the guide wire 1. It has angle (theta) 1 which the straight line L2 which is a tangent of the 1st taper part 13b comprises.

  Further, the second taper portion provided in the small diameter portion 13c of the coil body 13 is a tangent line between the straight line L3 parallel to the center line CL of the guide wire 1 and the second taper portion in the long axis direction of the guide wire 1. And an angle θ2 formed by the straight line L4.

  Furthermore, the angle θ1 of the first tapered portion 13b is designed to be larger than the angle θ2 of the second tapered portion.

  Thus, since the guide wire 11 has the 2nd taper part to which a coil outer diameter reduces toward the front-end | tip at the thin diameter part 13c of the coil body 13, insertion of the guide wire 11 in the constriction part in the blood vessel. Can be improved.

  Furthermore, the angle θ1 in the major axis direction of the guide wire 11 included in the first taper portion 13b of the coil body 13 is larger than the angle θ2 in the major axis direction of the second taper portion provided in the small diameter portion 13c of the coil body 13. Designed to increase the angle. For this reason, since the frictional resistance part 4 provided in the first taper part 13b of the coil body 13 can easily come into contact with the narrowed part in the blood vessel, the function as a temporary stopper can be secured. Further, the guide wire 11 can be prevented from unintentionally invading into the peripheral blood vessel in the peripheral direction from the portion, and blood vessel perforation of the peripheral blood vessel and damage to the blood vessel wall can be prevented, and the safety of the guide wire 11 can be ensured. .

  As a manufacturing method of the coil body 13, it can be manufactured by the same method as the method of manufacturing the coil body 3 in the first embodiment, and in this case, the core metal corresponding to the first tapered portion 13 b of the coil body 13 is produced. This shape (angle) needs to be made larger than the shape (angle) of the cored bar at the portion corresponding to the second tapered portion of the coil body 13. The coil body 13 can be manufactured by winding the wire forming the coil body 13 around the core metal, winding the core wire, and then extracting the core metal.

The second taper portion formed on the small-diameter portion 13c of the coil body 13 may be provided in a part of the small-diameter portion 13c, but as shown in FIG. 2A, from the distal end to the proximal end of the small-diameter portion 13c. Preferably, it is provided over the entire length.
Thus, by providing the second tapered portion over the entire length of the small-diameter portion 13c of the coil body 13, it is possible to improve the insertability of the guide wire 11 into the narrowed portion in the blood vessel.

  Further, since the guide wire 11 has the narrow portion 2c of the core shaft 2 and the intermediate portion of the first taper portion 13b of the coil body 13 fixed by the fixing portion 7, the coil body is formed in the narrowed portion in the blood vessel. Even when the 13 first tapered portions 13b come into contact with each other, the deformation of the first tapered portion 13b provided with the frictional resistance portion 4 can be prevented, and the temporary stopper function of the guide wire 11 can be improved.

  In addition, since the small diameter portion 2c of the core shaft 2 and the intermediate portion of the first taper portion 13b of the coil body 13 are fixed by the fixing portion 7, the friction provided in the first taper portion 13b of the coil body 13 When the resistance portion 4 comes into contact with a stenotic lesion, the touch when the resistance portion 4 comes into contact is transmitted to the small diameter portion 2c of the core shaft 2 via the fixing portion 7, and the operator more carefully operates the guide wire 11. It can be carried out. As a result, it is possible to improve the safety of the guide wire 11 by preventing peripheral blood vessel perforation and damage to the blood vessel wall.

  In addition, the fixing | fixed part 7 which fixes the small diameter part 2c of the core shaft 2 and the small diameter part 13c of the coil body 13 can be provided by the same method as the fixing | fixed part 7 formed in 1st Embodiment.

  Further, the fixing portion 7 for fixing the small-diameter portion 2c of the core shaft 2 and the first tapered portion 13b of the coil body 13 is a metal braze or metal solder mainly composed of gold such as gold braze or Au—Sn alloy. It is preferable to form by. Since the metal solder or metal solder mainly composed of gold has high rigidity, the deformation of the first taper portion 13b of the coil body 13 when the first taper portion 13b of the coil body 13 comes into contact with the narrowed portion in the blood vessel. Therefore, the temporary stopper function of the frictional resistance portion 4 provided on the first taper portion 13b of the coil body 13 can be further improved.

  Moreover, since the metal brazing and the metal solder mainly composed of gold have radiopacity, the visibility of the frictional resistance portion 4 under radioscopy can be improved. As a result, when the frictional resistance portion 4 comes into contact with the stenosis portion, it can be operated while confirming the position of the guide wire 11, thereby preventing unintended invasion into the peripheral blood vessels in the peripheral direction further than the stenosis portion. The safety of the guide wire 11 can be improved by preventing peripheral blood vessel perforation and damage to the blood vessel wall.

<Third Embodiment>
Next, the guide wire 21 according to the third embodiment will be described with reference to FIG. 3 focusing on differences from the first embodiment. Portions common to the first embodiment are denoted by the same reference numerals in the drawing.
In FIG. 3, in order to facilitate understanding, the length direction of the guide wire 21 is shortened and the entire guide wire 21 is schematically illustrated, and thus the overall dimensions are different from the actual dimensions.

  In FIG. 3, the guide wire 21 includes a core shaft 2, a coil body 3 that covers the distal end portion of the core shaft 2, and a lubricious coating 8 that covers a part of the distal end portion 6 and the small diameter portion 3 c of the coil body 3. The friction resistance portion 4 is provided over the entire length of the first taper portion 3 b of the coil body 3.

  Further, the small diameter portion 2 c of the core shaft 2 and the intermediate portion of the first tapered portion 3 b and the intermediate portion of the small diameter portion 3 c of the coil body 3 are fixed to each other by the fixing portion 7.

  Thus, since the guide wire 21 has the lubricating coating 8 on the small diameter portion 3c of the coil body 3, the insertion property of the guide wire 21 into the narrowed portion in the blood vessel can be further improved.

  Furthermore, the friction resistance portion 4 is provided over the entire length of the first taper portion 3b of the coil body 3, and the tip of the friction resistance portion 4 is located at the tip of the first taper portion 3b of the coil body 3. . For this reason, the temporary stopper function of the guide wire 21 with respect to the stenosis in the blood vessel can be further improved, so that unintentional intrusion into the peripheral blood vessel in the peripheral direction further than the stenosis can be prevented, and the vascular perforation of the peripheral blood vessel Damage to the blood vessel wall can be prevented, and the safety of the guide wire 21 can be further improved.

Further, the lubricating coating 8 may be provided over the entire length of the small-diameter portion 3c of the coil body 3, but as shown in FIG. 3, the portion separated from the first taper portion 3b of the coil body 3. , for example, it is preferable to form part excluding the base end of the small-diameter portion 3c of the coil body 3, of the lubrication coating 8 on the small-diameter portion 3c of the coil body 3.
If the lubricating coating 8 is formed over the entire length of the small diameter portion 3 c of the coil body 3, there is a possibility that the lubricating coating 8 is formed at the tip of the first tapered portion 3 b of the coil body 3. Thus, if the lubricating coating 8 is provided at the tip of the first tapered portion 3 b of the coil body 3, the stopper function by the frictional resistance portion 4 may be lowered, and therefore the first tapered portion of the coil body 3. It is better to avoid the formation of the lubricating coating 8 on the tip of 3b as much as possible. Further, in order to provide the lubricating coating 8 only on the entire length of the small diameter portion 3c without being applied to the tip of the first tapered portion 3b of the coil body 3, it is necessary to carefully form the lubricating coating 8.

  As a method of forming the lubricating coating 8 on the small diameter portion 3c of the coil body 3, a lubricating component solution prepared by dissolving the lubricating component of the lubricating coating 8 in a solvent, or a dispersion in which the lubricating component is dispersed is used. The small diameter portion 3c of the coil body 3 of the guide wire 21 is immersed in the liquid, and then the small diameter portion 3c of the coil body 3 of the guide wire 21 is dried to volatilize the solvent or the like, whereby the coil of the guide wire 21 is obtained. The lubricating coating 8 can be formed on the small diameter portion 3 c of the body 3.

  Further, the present invention is not limited to this, and a solution in which the lubricating component is dissolved or a dispersion in which the lubricating component is dispersed may be applied by brush or the like. The lubricating coating 8 may be formed on the small diameter portion 3c.

The material of the lubricating component that forms the lubricating coating 8 is not particularly limited. Examples of the hydrophilic polymer include polyvinyl alcohol, polyacrylamide, polymethylacrylamide, poly (2-hydroxyethyl methacrylate), Nonionic hydrophilic polymers such as poly (N-hydroxyethylacrylamide), anionic systems such as polyacrylic acid, polymethacrylic acid, polymaleic acid, carboxymethylcellulose, hyaluronic acid, poly (2-acrylamide-2methylpropanesulfonic acid) Hydrophilic polymers and cationic hydrophilic polymers such as polyethyleneimine, polyallylamine, and polyvinylamine can be used. A plurality of these hydrophilic polymers may be used, but when a plurality of ionic functional groups are used, it is better to unify them either anionic or cationic in order to prevent formation of an ion complex.
In addition, as the hydrophobic polymer, a silicone oil such as polydimethylsiloxane or a fluorine resin typified by polytetrafluoroethylene can be used.

<Fourth embodiment>
Next, a guide wire 31 according to the fourth embodiment will be described with reference to FIG. 4 focusing on differences from the first embodiment. Portions common to the first embodiment are denoted by the same reference numerals in the drawing.
In FIG. 4, in order to facilitate understanding, the length direction of the guide wire 31 is shortened and the entire guide wire 31 is schematically illustrated, and thus the overall dimensions are different from the actual dimensions.

  In FIG. 4, the guide wire 31 is the same as that of the third embodiment except that the lubricating coating 18 is composed of a thin portion 18a that forms the proximal end portion and a thick portion 18b that forms the distal end portion. Have the same structure.

  In such a guide wire 31, the lubricating coating 18 is composed of a thin portion 18a that forms the base end portion of the lubricating coating 18, and a thick portion 18b that forms the base end portion. The 18 thick-walled portions 18b can greatly enhance the lubricity of the distal end portion of the small-diameter portion 3c of the coil body 3, and can greatly improve the insertability of the guide wire 31 into the narrowed portion in the blood vessel. Further, the thin portion 18 a of the lubricating coating 18 can make the lubricity on the proximal end side of the small diameter portion 3 c of the coil body 3 lower than the lubricity on the distal end side of the small diameter portion 3 c of the coil body 3. Thereby, the speed at the time when the constriction part in the blood vessel collides with the first taper part 3b of the coil body 3 can be slightly reduced, and the friction resistance part 4 provided in the first taper part 3b of the coil body 3 temporarily The general stopper function can be further improved. As a result, it is possible to prevent unintentional invasion into the peripheral blood vessels in the peripheral direction further than the stenosis portion, to prevent peripheral blood vessel perforation and damage to the blood vessel wall, and to further improve the safety of the guide wire 31. it can.

  As a method for forming the lubricating coating 18 as described above, the same method as in the third embodiment can be employed. For example, the thin diameter portion 3c of the coil body 3 of the guide wire 31 is immersed in a solution in which the lubricity component is dissolved or a dispersion in which the lubricity component is dispersed, and then the guide wire 31 is dried. The distal end side of the small diameter portion 3c of the coil body 3 of the guide wire 31 is immersed in a solution in which the lubricating component is dissolved or a dispersion in which the lubricating component is dispersed, the guide wire 31 is dried, and the solvent is volatilized. Thus, the guide wire 31 can be manufactured.

As another method for forming the lubricating coating 18, for example, as shown in FIG. 4, the wire forming the tip side of the small diameter portion 3c of the coil body 3 is in a tightly wound state. A gap is formed between the strands of the coil strand forming the base end side.
Next, as described above, the small diameter portion 3c of the coil body 3 is immersed in a solution in which the lubricating component is dissolved or a dispersion in which the lubricating component is dispersed, and then the guide wire 31 is dried. Then, since a gap is formed between the strands of the coil wire on the proximal end side of the small diameter portion 3c of the coil body 3, a solution in which the lubricating component is dissolved or a dispersion in which the lubricating component is dispersed is obtained. Since it penetrates into the inside of the coil body 3, the thin portion 18 a of the lubricating coating 18 can be obtained. Further, since the coil wire is in a tightly wound state at the distal end side of the small diameter portion 3 c of the coil body 3, a solution in which the lubricating component is dissolved or a dispersion liquid in which the lubricating component is dispersed penetrates into the coil body 3. The thick part 18b of the lubricating coating 18 can be formed.

  According to this method, the guide wire 31 having the thin portion 18 a of the lubricating coating 18 is provided by providing a gap between the strands of the coil wire that forms the proximal end side of the small diameter portion 3 c of the coil body 3. Can be easily formed.

  Further, the thin portion 18a of the lubricating coating 18 may have a structure in which the thickness of the lubricating coating 18 is decreased from the distal end toward the proximal end. The guide wire 31 having such a coating is formed, for example, with the gap between the strands of the coil wire forming the proximal end side of the thin diameter portion 3c of the coil body 3 being set at the distal end of the small diameter portion 3c of the coil body 3. The coil body 3 enlarged as it goes from the base end direction toward the base end direction is formed, and thereafter, it can be manufactured by using the method for forming the lubricating coating 18 described above.

  Further, the lubricating coating 18 having different lubricating properties may be formed on the distal end side and the proximal end side of the lubricating coating 18. In the guide wire 31 having such a coating, for example, the distal end side of the lubricating coating 18 is formed of the aforementioned hydrophilic polymer, and the proximal end side of the lubricating coating 18 is formed of the aforementioned hydrophobic polymer. Can be produced.

<Fifth Embodiment>
Next, the guide wire 41 according to the fifth embodiment will be described with reference to FIGS. 5A and 5B, focusing on differences from the first embodiment. Portions common to the first embodiment are denoted by the same reference numerals in the drawing.
In FIG. 5A, the length direction of the guide wire 41 is shortened and the entire guide wire 41 is schematically shown for easy understanding, and therefore the overall dimensions are different from the actual dimensions. .

  Moreover, FIG.5 (b) expands the enlarged rectangular part A surrounding a part of 1st taper part 3b of the coil body 3 of Fig.5 (a). Further, the fixing portion 7 that fixes the small-diameter portion 2c of the core shaft 2 and the first tapered portion 3b of the coil body 3 is omitted for easy explanation. 5B, the upper part corresponds to the core shaft 2 side, and the lower part corresponds to the outer surface direction of the coil body 3 in the figure.

  5 (a) and 5 (b), the guide wire 41 has the frictional resistance portion 14 formed by the uneven portion 5 provided on the surface of the coil wire constituting the first tapered portion 3b of the coil body 3. Except for, it has the same structure as the third embodiment. In addition, the uneven | corrugated | grooved part 5 of FIG.5 (b) is formed toward the outer surface direction of the coil body 3, and the uneven | corrugated | grooved part 5 is not formed in the inner surface side of the coil body 3. FIG.

  Since such a guide wire 41 has the friction resistance part 14 formed by the uneven part 5 provided on the surface of the coil wire constituting the first taper part 3b of the coil body 3, the friction resistance part 14 Can be configured easily. Furthermore, since the guide wire 41 has the concavo-convex portion 5, physical friction increases between the friction resistance portion 14 and the narrowed portion, and the friction resistance portion 14 provided on the first taper portion 3 b of the coil body 3. It is possible to further improve the stopper function. Thereby, there exists an effect which further improves the safety of a guide wire.

  As a method of forming the concavo-convex portion 5 on the surface of the coil wire constituting the first taper portion 3b of the coil body 3, a large-diameter portion 3a and a small-diameter portion 3c of the coil body 3 are molded with a mold, fluorine-based heat. There is a sputtering method, a blast method, a cutting method, or the like in a state where the surface of the first tapered portion 3b is exposed by masking with a shrinkable tube or a masking tape. In addition, other known methods can be used without being limited thereto.

  As materials used in the sputtering method, radiolucent stainless steel, radiopaque metals such as gold and platinum, and ceramics having excellent biocompatibility such as hydroxyapatite can be used.

  Among these, it is preferable to form the concavo-convex portion 5 with a radiopaque metal such as gold or platinum. By forming the concavo-convex portion 5 with a radiopaque metal, the visibility of the frictional resistance portion 14 under radioscopy can be improved. As a result, when the frictional resistance portion 14 comes into contact with the stenosis portion, it can be operated while confirming the position of the guide wire 41, thereby preventing unintended invasion into the peripheral blood vessels in the peripheral direction further than the stenosis portion. Further, the perforation of peripheral blood vessels and the damage of the blood vessel wall can be prevented, and the safety of the guide wire 41 can be further improved.

  Further, as a polishing material used in the blasting method, glass beads having a large particle diameter, alumina oxide beads, and stainless steel beads can be used in order to form a relatively rough uneven portion 5.

  Further, in the cutting method, by using a tool such as a reuter, the corners of the grindstone attached to the reuter are brought into contact with the first tapered portion 3b of the coil body 3, whereby the uneven portion 5 is formed on the surface of the first tapered portion 3b. Thus, the frictional resistance portion 14 can be manufactured.

  In FIG. 5B, the uneven portion 5 is formed on the outer surface side of the first tapered portion 3 b of the coil body 3, but the first tapered portion 3 b of the coil body 3 is not limited to this. The concavo-convex portion 5 may be formed on the entire circumference of the coil wire forming the wire.

  In this case, the concavo-convex portion 5 is formed on the entire circumference of the coil wire having a certain length forming the first taper portion 3b of the coil body 3, and the coil wire is described as described in the first embodiment. The coil body 3 can be obtained by winding the coil body 3 so that the portion having the concavo-convex portion 5 on the entire circumference corresponds to the taper portion of the core metal.

<Sixth Embodiment>
Next, the guide wire 51 according to the sixth embodiment will be described with reference to FIG. 6 focusing on differences from the first embodiment. Portions common to the first embodiment are denoted by the same reference numerals in the drawing.
In FIG. 6, for ease of understanding, the length direction of the guide wire 51 is shortened and the entire guide wire 51 is schematically illustrated, so that the overall dimensions are different from the actual dimensions.

In FIG. 6, the guide wire 51 has a small diameter portion 2 c of the core shaft 2 and a proximal end of the frictional resistance portion 4, that is, a proximal end of the first tapered portion 3 b of the coil body 3 fixed by the fixing portion 7 a. Except that the small diameter portion 2c of the core shaft 2 and the tip of the friction resistance portion 4, that is, the tip of the first taper portion 3b of the coil body 3 are fixed by the fixing portion 7b. It has the same structure as 3 embodiment.
The small diameter portion 2c of the core shaft 2 and the small diameter portion 3c of the coil body 3 are fixed by a fixing portion 7c.

  In such a guide wire 51, the fixing portion 7a and the base end of the friction resistance portion 4 are provided at the base end of the first taper portion 3b. Can be brought into contact with the stenosis. Thereby, the stopper function by the frictional resistance part 4 can be improved, and the safety | security of the guide wire 51 can be improved.

  Further, since the guide wire 51 has the fixing portion 7b and the tip of the friction resistance portion 4 provided at the tip of the first taper portion 3b, even when the first taper portion 3b and the narrowed portion in the blood vessel are in contact with each other. In addition, it is possible to reliably prevent the tip of the first tapered portion 3b from being deformed, and to greatly improve the stopper function of the frictional resistance portion 4 provided on the first tapered portion 3b. Thereby, there exists an effect which improves the safety | security of the guide wire 51 significantly.

  Note that a fixing portion that is fixed to the small-diameter portion 2c of the core shaft 2 may be provided over the entire length of the first taper portion 3b of the coil body 3, but the rigidity of the distal end portion of the guide wire 51 is rapidly increased. Therefore, it is preferable to form the fixing portion 7a and the fixing portion 7b as separate bodies from the viewpoint of ensuring flexibility.

  Further, in order to surely prevent the deformation of the first tapered portion 3b of the coil body 3, it is preferable to form the fixing portion 7a and the fixing portion 7b at the same time, but the present invention is not limited to this. The fixing portion may be formed on the guide wire 51. When either one of the fixing portions is provided, from the viewpoint of improving the stopper function of the guide wire 51, the small diameter portion 2c of the core shaft 2 and the friction resistance portion 4, that is, the first taper portion 3b of the coil body 3 are used. It is preferable to provide an adhering portion 7b that adhering to the tip of each of the members.

  Further, the present invention is not limited to the above-described embodiments, and various modifications can be made by those skilled in the art within the technical idea of the present invention.

  For example, in the guide wire 11 according to the second embodiment illustrated in FIG. 2, the boundary between the tapered portion 2 b of the core shaft 2 and the core shaft 2 c is defined between the small diameter portion 2 c of the core shaft 2 and the first of the coil body 3. The friction resistance portion 4 provided on the first taper portion 3b of the coil body 3 by preventing the deformation of the first taper portion 3b of the coil body 3 by providing the taper portion 3b at the position of the fixing portion 7 to which the taper portion 3b is secured. The temporary stopper function may be improved.

  Further, in the guide wire 21 according to the third embodiment shown in FIG. 3, a lubricating film may be formed also on the large diameter portion 3 a of the coil body 3.

  In addition, the coil body is within a range in which the lubricity is lowered as compared with the lubricity coating 8 provided on the small diameter portion 3c of the coil body 3 of the guide wire 21 and the friction due to the stopper function of the friction resistance portion 4 can be sufficiently secured. A lubricating film may be formed very thin on the first tapered portion 3b.

  Further, regardless of the shape of the core shaft 2 of the present embodiment, a plurality of tapered portions 2b and small diameter portions 2c may be provided, and the outer diameter of the core shaft 2 may be changed through a plurality of stages.

  Moreover, you may provide a some taper part and a some friction resistance part in the range which has a stopper function irrespective of the shape of the coil body of this embodiment.

  Further, for example, when the first tapered portion 3b of the coil body 3 of the guide wire 1 and the small diameter portion 2c of the core shaft 2 are not fixed by the fixing portion 7 as in the first embodiment, the guide wire 1 The first taper portion 3b of the coil body 3 is preferably formed by winding a part or all of the coil wire forming the first taper portion 3b of the coil body 3 in close winding. By winding the first taper portion 3b of the coil body 3 in close winding, the play of the first taper portion 3b of the coil body 3 is eliminated, so that the deformation of the first taper portion 3b of the coil body 3 can be prevented. it can. Thereby, since the frictional resistance part 4 provided in the 1st taper part 3b of the coil body 3 and a stenosis lesion | contact are firmly in contact, the stopper function of the guide wire 1 is further improved and the safety | security of the guide wire 1 is improved. be able to.

1, 11, 21, 31, 41, 51 Guide wire 2 Core shaft 2a Large diameter portion (core shaft)
2b Taper part (core shaft)
2c Small diameter part (core shaft)
3, 13 Coil bodies 3a, 13a Large diameter part (coil body)
3b, 13b 1st taper part (coil body)
3c, 13c Small diameter part (coil body)
4,14 frictional resistance portion 5 concave-convex portion 6 leading edge portion 7, 7a, 7b, 7c fixed portion 8, 18 lubricious coating 18a thin-walled portion (lubricious coating)
18b thick portion (lubricious coating)
9 Brazing

Claims (7)

A core shaft and a coil body covering the core shaft;
The coil body includes a small diameter portion, a large diameter portion, and a first taper portion located between the small diameter portion and the large diameter portion,
At least a part of the first taper portion is provided with a friction resistance portion having a higher friction resistance than the small diameter portion ,
The part of the first taper portion provided with the frictional resistance portion and the core shaft are fixed to each other by a fixing portion, or the distal end side of the large-diameter portion of the coil body and the coil body A guide wire in which intermediate portions of the narrow-diameter portions are fixed to the core shaft by fixing portions . The guidewire according to claim 1, wherein
The small-diameter portion has a second taper portion in which the outer diameter of the coil decreases toward the distal direction,
The guide wire in which an angle with respect to the major axis direction of the second tapered portion is smaller than an angle with respect to the major axis direction of the first tapered portion. The guide wire according to claim 1 or 2,
A guide wire in which a lubricating coating is formed at a position spaced apart from the first tapered portion of the small diameter portion. The guide wire according to any one of claims 1 to 3,
The said friction resistance part is a guide wire formed of the uneven | corrugated | grooved part provided in the surface of the strand which forms a coil body. The guide wire according to any one of claims 1 to 4,
A guide wire, wherein a tip of the friction resistance portion is located at a tip of the first taper portion. The guidewire according to claim 1, wherein
The tip of the friction resistance portion is located at the tip of the first taper portion,
The fixed portion is a guide wire located at a tip of the first tapered portion. The guidewire according to claim 1, wherein
A distal end side of the large diameter portion of the coil body and an intermediate portion of the small diameter portion of the coil body are fixed to each other by a fixing portion to the core shaft; and
A guide wire in which part or all of the strands forming the coil body of the first tapered portion provided with the frictional resistance portion are wound in close winding.

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