JP5318684B2 - Syringe and syringe assembly - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a syringe and a syringe coupler capable of facilitating the sucking operation when a liquid is sucked from a liquid container in the negative pressure state. <P>SOLUTION: A first syringe 2 (the same as a second syringe 3) is connected to a first chemical container 100 having a storage space 105 in the negative pressure state in which a first chemical Q1 is stored. The first syringe 2 includes an outer barrel 21 with a mouth 22 connected to the first chemical container 100, and a gasket 24 inserted into the outer barrel 21 to move along the longitudinal direction. A vent hole 213 penetrating the wall 212 of the outer barrel 21 is formed in the outer barrel 21. The storage space 105 communicates with a filling space 25 in the first syringe 2 when the mouth 22 is connected to the first chemical container 100 with the gasket 24 of the first syringe 2 located on the proximal end side from the vent hole 213, and the negative pressure state of the storage space is released as air G flows into the filling space 25 via the vent hole 213. <P>COPYRIGHT: (C)2011,JPO&amp;INPIT

Description

  The present invention relates to a syringe and a syringe connector.

  In a medical institution or the like, for example, when a drip injection (infusion) is performed on a patient, an antiadhesive material, a biological tissue adhesive, or the like is administered, the drug is diluted or dissolved with a liquid, and the drug solution is syringed In some cases, it is used after sucking. These operations are performed as follows.

  First, using a connector having a hollow double-ended needle, one of the double-ended needles is connected to a liquid container containing a liquid, and the other is connected to a drug container containing a drug. Transfer the liquid into the drug container. Thereby, the chemical | medical agent in a chemical | medical agent container is diluted with a liquid (or melt | dissolved), and the dispensed chemical | medical solution is obtained (for example, refer patent document 1). In addition, since the inside of the medicine container is in a negative pressure state, the liquid is smoothly transferred from the liquid container to the medicine container.

  Next, the double-ended needle is removed from the drug container, and a syringe to which a puncture needle having a sharp needle tip is connected is punctured (pierced) into the plug body of the drug container. Is sucked and filled into the outer cylinder of the syringe.

  Then, using a syringe filled with the drug solution, drip injection, adhesion prevention material, biological tissue adhesive, or the like is administered.

  By the way, in invention of patent document 1, when connecting a syringe to a chemical | medical agent container and attracting | sucking a chemical | medical solution from the said chemical | medical agent container, since the inside of a chemical | medical agent container is a negative pressure state as mentioned above, the pusher of a syringe There is a problem that it is difficult to perform a chemical solution suction operation by pulling the wire.

Japanese Patent Laid-Open No. 2001-333961

  An object of the present invention is to provide a syringe and a syringe assembly capable of easily performing a suction operation when sucking a liquid from a liquid container in a negative pressure state.

Such an object is achieved by the present inventions (1) to (8) below.
(1) A syringe connected to a liquid container having a storage space in which liquid is stored and in a negative pressure state,
A syringe outer cylinder formed at the tip and having a mouth connected to the liquid container;
A gasket that moves in a liquid-tight manner along the longitudinal direction of the inner surface of the syringe outer cylinder;
An operation member for moving the gasket,
The syringe outer cylinder is formed with a vent hole penetrating the wall portion,
The storage space communicates with a space surrounded by the syringe outer cylinder and the gasket when the mouth portion is connected to the liquid container in a state where the gasket is located on the proximal end side with respect to the vent hole. The syringe is characterized in that the negative pressure state is released when outside air flows into the enclosed space through the vent hole.

  (2) By pressing the operation member, the gasket moves in the distal direction and once exceeds the vent hole, and then the gasket is prevented from moving again in the proximal direction beyond the vent hole. The syringe as described in said (1) provided with the control means to do.

(3) The syringe outer cylinder has a plate-like flange formed so as to protrude from the base end portion thereof,
The restricting means is provided on the operation member, and engages with a part of the flange before the gasket again moves in the proximal direction beyond the vent hole, and moves toward the proximal direction of the gasket. The syringe as described in said (2) which has an engaging part which controls a movement.

(4) A through-hole penetrating in the thickness direction is formed in the flange,
The engaging portion has a claw that can engage with an edge portion of the through hole at a distal end portion, and is configured by a pair of elastic pieces that can approach and separate from each other.
The pair of elastic pieces are respectively positioned on the proximal end side with respect to the flange in a state where the gasket is positioned on the proximal end side with respect to the vent hole, and the gasket moves in the distal direction from the state, and the passage is performed. When crossing the pores, they approach each other and pass through the through hole, and when the gasket moves in the proximal direction and tries to cross the vent hole again, they are separated from each other and the pawls of the through hole The syringe according to (3), which is engaged with the edge.

  (5) The syringe according to any one of (1) to (4), wherein the vent hole is formed near a proximal end portion of the syringe outer cylinder.

  (6) The syringe according to any one of (1) to (5), wherein a filter member having a bacteria-impermeable property that covers the ventilation hole is installed in the ventilation hole.

  (7) Said syringe outer cylinder is provided with the said blockage | prevention prevention means which prevents that said vent hole is block | closed by the operator's hand, when connecting the said opening to the said liquid container. ).

  (8) A syringe assembly comprising a plurality of the syringes according to any one of (1) to (7) arranged and connected.

  Further, in the syringe of the present invention, the blocking prevention means is composed of a plurality of protrusions that are formed to protrude around the vent hole of the wall portion of the syringe outer cylinder and are intermittently arranged along the circumferential direction thereof. It is preferable.

  Moreover, in the syringe of the present invention, it is preferable that the blocking prevention means is constituted by a marker attached to the periphery of the vent hole in the wall portion of the syringe outer cylinder and pointing to the vent hole.

  In the syringe according to the present invention, it is preferable that the blocking prevention means is constituted by a tube connectable to the vent hole.

  According to the present invention, when the operation member of the syringe is pulled to suck the liquid from the negative pressure liquid container, the negative pressure state of the liquid container is released prior to the suction operation (pull operation). Can do. The operation of sucking the chemical liquid from the liquid container in which the negative pressure state has been released is much easier than the operation of sucking the chemical liquid from the liquid container in the negative pressure state.

It is a perspective view which shows the state which connected the syringe coupling body (syringe) of this invention to the chemical | medical solution container. It is a longitudinal cross-sectional view which shows the operation method of the syringe coupling body of the state shown in FIG. 1 in order. It is a longitudinal cross-sectional view which shows the operation method of the syringe coupling body of the state shown in FIG. 1 in order. It is a longitudinal cross-sectional view which shows the operation method of the syringe coupling body of the state shown in FIG. 1 in order. It is a longitudinal cross-sectional view which shows the operation method of the syringe coupling body of the state shown in FIG. 1 in order. It is a longitudinal cross-sectional view which shows the ventilation hole vicinity of the syringe of the syringe coupling body (2nd Embodiment) of this invention. It is a side view which shows the ventilation hole vicinity of the syringe of the syringe coupling body (3rd Embodiment) of this invention. It is the sectional view on the AA line in FIG. It is a side view which shows the ventilation hole vicinity of the syringe of the syringe coupling body (4th Embodiment) of this invention. It is a fragmentary longitudinal cross-section which shows the ventilation hole vicinity of the syringe of the syringe coupling body (5th Embodiment) of this invention.

  Hereinafter, the syringe and syringe assembly of the present invention will be described in detail based on preferred embodiments shown in the accompanying drawings.

<First Embodiment>
FIG. 1 is a perspective view showing a state where the syringe assembly (syringe) of the present invention is connected to a chemical solution container, and FIGS. 2 to 5 are longitudinal sections sequentially illustrating the operation method of the syringe assembly in the state shown in FIG. FIG. In the following, for convenience of explanation, the upper side in FIGS. 1 to 4 is referred to as “base end”, “upper” or “upper”, and the lower side is referred to as “tip”, “lower” or “lower”. Further, the upper side in FIG. 5 is referred to as “tip”, “upper” or “upper”, and the lower side is referred to as “base”, “lower” or “lower”.

  A syringe assembly 1 shown in FIG. 1 includes a first syringe 2 and a second syringe 3, and these syringes are connected side by side. As shown in FIG. 2, the first syringe 2 and the second syringe 3 are each empty in an unused state (initial state). The first syringe 2 is connected to the first drug container 100, and in this state, the first drug solution (liquid drug) Q1 can be sucked from the first drug container 100 (FIG. 2). (See FIG. 5). Similarly, the second drug container 200 is connected to the second syringe 3, and in this state, the second drug solution (liquid drug) Q2 can be sucked from the second drug container 200 ( 2 to 5).

  First, before describing the syringe assembly 1, the first drug container 100 and the second drug container 200 will be described.

  Although it does not specifically limit as the 1st chemical | medical agent container 100 and the 2nd chemical | medical agent container 200, respectively, For example, a vial etc. can be used. In this case, since the first drug container 100 and the second drug container 200 have substantially the same configuration except that the shapes are different, the first drug container 100 will be described as a representative.

  As shown in FIG. 1, the 1st chemical | medical agent container 100 has the hard bottle main body 101 which makes bottomed cylindrical shape. The bottle main body 101 has a port portion 102 formed with a port portion opening (mouth) on the upper side via a neck portion 103 having the smallest outer diameter. A plug 104 that hermetically seals the port opening is attached to the port 102 (see, for example, FIG. 2).

  The constituent material of the bottle body 101 is not particularly limited, and for example, various glasses, polyvinyl chloride, polyethylene, polypropylene, cyclic polyolefin, polystyrene, poly- (4-methylpentene-1), polycarbonate, acrylic resin, acrylonitrile. -Various resins such as butadiene-styrene copolymer, polyester such as polyethylene terephthalate, polyethylene naphthalate, butadiene-styrene copolymer, polyamide (for example, nylon 6, nylon 6,6, nylon 6,10, nylon 12). Etc. Further, the glass and the resin are preferably a resin, and when the bottle body 101 is made of a resin, the incineration can be discarded, and the time and effort for disposal can be reduced. In addition, in order to ensure the visibility inside, the bottle main body 101 has a light transmittance, and it is preferable that it is transparent or translucent.

  The plug body 104 can be pierced by a needle body 81 of a puncture needle 8 to be described later, and its constituent material is not particularly limited. For example, natural rubber, butyl rubber, isoprene rubber, butadiene rubber, styrene-butadiene Examples thereof include various rubber materials such as rubber and silicone rubber, various thermoplastic elastomers such as polyurethane, polyester, polyamide, olefin, and styrene, or elastic materials such as a mixture thereof.

  Here, the first drug container 100 and the second drug container 200 have different shapes. In the present embodiment, the volume of the first drug container 100 is larger than the volume of the second drug container 200. That is, the first drug container 100 is larger in the outer diameter of the bottle body 101, the port part 102 and the neck part 103 and the inner diameter of the bottle body 101 than the second drug container 200.

  In the first drug container 100, the first drug solution Q1 is stored in the storage space 105, which is the internal space, and in the second drug container 200, the second drug solution Q2 is stored in the storage space 105. ing. The first chemical solution Q1 and the second chemical solution Q2 are different from each other, and are appropriately selected according to the use, purpose of use, case, and the like. For example, when the first drug solution Q1 and the second drug solution Q2 are mixed and the mixed solution is to be used as a biological tissue adhesive, one drug solution can be thrombin and the other drug solution can be fibrinogen. it can. Further, when the mixed solution of the first chemical solution Q1 and the second chemical solution Q2 is used as an anti-adhesive material, one chemical solution can be carboxymethyldextrin modified with a succinimidyl group, and the other chemical solution is sodium bicarbonate. And sodium carbonate. In addition, mixing with the 1st chemical | medical solution Q1 and the 2nd chemical | medical solution Q2 can be performed using the syringe coupling body 1. FIG. This will be described later.

  In addition, the storage space 105 of each of the first drug container 100 and the second drug container 200 is in a negative pressure state (depressurized state).

  As shown in FIG. 1, the first drug container 100 and the second drug container 200 are connected in a lined state via a connecting member 9 and held together. 2-5, the connection member 9 and the connection tool 7 are abbreviate | omitted.

  The connecting member 9 includes a first holding part 91 that holds the port part 102 of the first drug container 100 and a second holding part 92 that holds the port part 102 of the second drug container 200. Yes. The first holding part 91 and the second holding part 92 are integrally formed.

  The first holding part 91 is a cylindrical part and can be fitted to the port part 102 of the first medicine container 100. The second holding portion 92 is also a cylindrical portion like the first holding portion 91 and can be fitted into the port portion 102 of the second drug container 200.

  A connecting member 7 is attached to the connecting member 9. The connection tool 7 connects the first drug container 100 and the first syringe 2 and connects the second drug container 200 and the second syringe 3.

  The connection tool 7 includes an attachment portion 71 attached to the upper part of the connecting member 9, a first connection portion 72 to which the puncture needle 8 of the first syringe 2 is connected, and a puncture needle 8 of the second syringe 3. And a second connecting portion 73 to be connected.

  The mounting portion 71 includes a top plate 711 and a wall portion 712 that protrudes downward from the edge of the top plate. This wall portion can be fitted together with the first holding portion 91 and the second holding portion 92 of the connecting member 9. Thereby, the connection tool 7 is reliably attached to the connecting member 9.

  Further, the top plate 711 is formed with a cylindrical first connection portion 72 and a second connection portion 73 that protrude upward. When the puncture needle 8 of the first syringe 2 is connected to the first connection portion 72, the puncture needle 8 has its hub 82 fitted into the first connection portion 72 and the needle body 81 is the first drug container. 100 plugs 104 are pierced (see FIGS. 2 to 5). When the puncture needle 8 of the second syringe 3 is connected to the second connection portion 73, the puncture needle 8 has its hub 82 fitted into the second connection portion 73 and the needle body 81 is the second drug container. 200 plugs 104 are inserted (see FIGS. 2 to 5).

  Next, the syringe assembly 1 will be described. As described above, the syringe assembly 1 is obtained by connecting the first syringe 2 and the second syringe 3 in parallel. The first syringe 2 can be filled with the first drug solution Q1 from the first drug container 100. The second syringe 3 can be filled with the second drug solution Q2 from the second drug container 200. Since the first syringe 2 and the second syringe 3 have substantially the same configuration except that their volumes (sizes) are different from each other, the first syringe 2 will be described as a representative. In the present embodiment, the volume of the first syringe 2 is larger than the volume of the second syringe 3. That is, the thickness of the first syringe 2 is thicker than the thickness of the second syringe 3.

  The first syringe 2 includes an outer cylinder (syringe outer cylinder) 21, a gasket 24 that can slide in the outer cylinder 21, and a push that moves the gasket 24 along the longitudinal direction (axial direction) of the outer cylinder 21. A child (plunger rod (operation member)) 26 and a puncture needle 8 attached to the outer cylinder 21 are provided. The gasket 24 is connected to the tip of the pusher 26.

  The outer cylinder 21 is composed of a bottomed cylindrical member, and a mouth portion (reduced diameter portion) 22 having a diameter reduced with respect to the body portion of the outer cylinder 21 is integrally formed at the center of the bottom portion 211. ing.

  Further, the wall portion (tube wall) 212 of the outer cylinder 21 is provided with a scale (not shown) indicating the liquid amount.

  A flange 23 is integrally formed on the base end portion (rear end outer periphery) of the outer cylinder 21. The flange 23 is a plate-shaped portion protruding outward. For example, when the pusher 26 is moved relative to the outer cylinder 21, the operation can be performed by placing a finger on the flange 23. The flange 23 extends to the proximal end portion of the outer cylinder 21 of the second syringe 3 adjacent to the outer cylinder 21 of the first syringe 2, and also has a function of connecting these outer cylinders 21 to each other. Yes.

  Further, the flange 23 is formed with an engagement hole 28 in which a part of a pusher coupling body 27 in which the pusher 26 of the first syringe 2 and the pusher 26 of the second syringe 3 are coupled can be engaged. ing. The engagement hole 28 is a through hole that penetrates the flange 23 in the thickness direction. Further, the engagement hole 28 is disposed between the outer cylinder 21 of the first syringe 2 and the outer cylinder 21 of the second syringe 3.

  Although it does not specifically limit as a constituent material of the outer cylinder 21 and the presser 26 (presser coupling body 27), For example, a polyvinyl chloride, polyethylene, a polypropylene, cyclic polyolefin, a polystyrene, poly- (4-methylpentene-1) , Polycarbonate, acrylic resin, acrylonitrile-butadiene-styrene copolymer, polyester such as polyethylene terephthalate, polyethylene naphthalate, butadiene-styrene copolymer, polyamide (for example, nylon 6, nylon 6,6, nylon 6,10, Various resins such as nylon 12) can be mentioned. Among them, resins such as polypropylene, cyclic polyolefin, and polyester are preferable in terms of easy molding and low water vapor permeability. In addition, it is preferable that the constituent material of the outer cylinder 21 is substantially transparent in order to ensure internal visibility.

  The puncture needle 8 is attached to the mouth portion 22 of the outer cylinder 21. The puncture needle 8 is composed of a needle body 81 having a sharp needle tip 811 at the tip and a hub 82 installed at the proximal end portion of the needle body 81. The needle body 81 is a hollow needle and can puncture the plug body 104 of the first drug container 100 in which the first drug solution Q1 is stored (see FIGS. 2 to 5). The hub 82 is attached to the mouth portion 22 of the outer cylinder 21. The hub 82 has a cylindrical shape and can be fitted into the mouth portion 22. Thereby, the puncture needle 8 is attached to the mouth portion 22 of the outer cylinder 21, and the mouth portion 22 is connected to the first drug container 100 via the puncture needle 8 and the connection tool 7 described above. .

  A gasket 24 made of an elastic material is accommodated (inserted) in the outer cylinder 21. The gasket 24 has a disc shape, and the outer diameter of the gasket 24 gradually decreases in the distal direction. The shape of the tip portion corresponds to the shape of the bottom portion 211 of the outer cylinder 21. Further, the outer peripheral surface of the gasket 24 is slid while being in close contact with the inner peripheral surface of the outer cylinder 21, so that the outer cylinder 21 is surrounded by the outer cylinder 21 and the gasket 24 while maintaining liquid tightness. The first chemical Q1 filled in the filled space (space) 25 can be pushed out toward the mouth portion 22.

  The constituent material of the gasket 24 is not particularly limited. For example, various rubber materials such as natural rubber, butyl rubber, isoprene rubber, butadiene rubber, styrene-butadiene rubber, silicone rubber, polyurethane, polyester, polyamide, Examples thereof include elastic materials such as various thermoplastic elastomers such as olefins and styrenes, or mixtures thereof.

  The outer cylinder 21 has one vent hole 213 formed in the wall 212 thereof. The ventilation hole 213 is configured by a through-hole penetrating the wall portion 212 and allows air G to pass through (see FIG. 2). The vent hole 213 is formed near the proximal end portion of the outer cylinder 21 (near the flange 23). The vent hole 213 has a circular shape, and its diameter is preferably 0.4 to 1.2 mm, for example, although it depends on the size (thickness) of the outer cylinder 21.

  The gasket 24 is in a first position (see FIG. 2) on the base end side of the vent hole 213 when the syringe assembly 1 is not used. At this time, in the first syringe 2, the filling space 25 communicates with the atmosphere via the vent hole 213. As shown in FIG. 2, when such a first syringe 2 is connected to the first drug container 100, as described above, the puncture needle 8 (needle body 81) of the first syringe 2 is in the first state. The stopper 104 of the medicine container 100 is pierced. Thereby, the storage space 105 of the first medicine container 100 communicates with the filling space 25 of the first syringe 2 via the puncture needle 8. Since the storage space 105 is in a negative pressure state, the air G flows into the filling space 25 communicating with the storage space 105 through the vent hole 213. As a result, one space where the storage space 105 and the filling space 25 communicate with each other is opened to the atmosphere via the vent hole 213. As a result, the storage space 105 that has been in a negative pressure state is released from the negative pressure state and has the same pressure as the atmosphere.

  Then, by pressing the pusher 26 (the pusher coupling body 27), the gasket 24 at the first position is moved beyond the vent hole 213 to the second position on the tip side of the vent hole 213. (See FIGS. 3-5). The gasket 24 in the second position blocks communication between the filling space 25 of the first syringe 2 and the atmosphere.

  Furthermore, as shown in FIG. 4, for example, when the gasket 24 is pushed until the gasket 24 abuts against the bottom 211 of the outer cylinder 21, the volume of the filling space 25 is reduced, and the internal pressure of the storage space 105 is correspondingly reduced. Ascending, that is, the storage space 105 is pressurized. From the state shown in FIG. 4, it is turned upside down as shown in FIG. As a result, the pressurized air in the storage space 105 is positioned on the proximal end side with respect to the first chemical Q1 in the storage space 105. In this state, when the pressing force on the pusher 26 is released, the gasket 24 is retracted by the internal pressure of the storage space 105 (the pressurized air). As a result, the volume of the filling space 25 increases and the internal pressure of the filling space 25 decreases, so that the first chemical Q1 can be sucked into the filling space 25 from the storage space 105.

  Such a series of operations and states are the same for the second syringe 3 and the second drug container 200.

  As described above, in the syringe connector 1, the pusher connector 27 is pulled to suck the first drug solution Q1 from the first drug container 100 in the negative pressure state, and the second drug in the negative pressure state. When the second drug solution Q2 is sucked from the container 200, the negative pressure state of each drug container can be released prior to the suction operation. The operation of sucking the drug solution from each drug container in which the negative pressure state is released is much easier than the operation of sucking the drug solution from each drug container in the original negative pressure state.

  Further, as described above, the vent hole 213 is formed in the vicinity of the proximal end portion of the outer cylinder 21. Thereby, the size of the filling space 25 can be sufficiently secured. Here, “sufficient” means that the internal pressure of the storage space 105 is increased to the extent that the gasket 24 is retracted by pressing the gasket 24 from the first position and reducing the volume of the filling space 25. Say that.

  Further, in the syringe assembly 1, when performing the suction operation, the suction operation is performed after the gasket is moved to a position where it comes into contact with the bottom portion 211 of the outer cylinder 21, but the present invention is not limited to this. The suction operation can be performed from any position within the range of the position, that is, between the vent hole 213 and the bottom portion 211 of the outer cylinder 21.

  As described above, the gasket 24 can move along the longitudinal direction of the outer cylinder 21, and the movement is performed by pulling or pressing the pusher coupling body 27 (presser 26). Here, the pusher connector 27 will be described.

  As shown in FIG. 1, the pusher connector 27 is obtained by connecting the pushers 26 of the first syringe 2 and the second syringe 3 to each other at the base end portions. Thereby, the two pushers 26 can be collectively operated. Each pusher 26 is a rod-like body whose cross section is a cross shape. A gasket 24 is fixed to the tip of the pusher 26 by, for example, screwing.

  The pusher connector 27 is integrally formed with a plate-like flange 271 at its base end. When the pusher coupling body 27 is moved relative to the outer cylinder 21, the operation can be performed by placing a finger on the flange 271.

  As shown in FIGS. 2 to 5 (also in FIG. 1), the pusher connector 27 is provided with a long engagement member 29 that passes through the engagement hole 28 of the flange 23 of the outer cylinder 21. ing. The engaging member 29 is disposed between the two pushers 26 in parallel with each pusher 26.

  The engaging member 29 has a pair of elastic pieces 291 a and 291 b as engaging portions that can be engaged with the engaging holes 28 of the flange 23 of the outer cylinder 21 at the distal end thereof. The elastic piece 291a and the elastic piece 291b are disposed to face each other and can be separated from each other.

  Each of the elastic pieces 291a and 291b has a claw 292 formed by folding the middle in the longitudinal direction outward. As shown in FIG. 5, each claw 292 can engage with the edge of the engagement hole 28 of the flange 23 of the outer cylinder 21.

  Next, the operation of the engagement member 29 having such a configuration will be described together with an example of a method for using the syringe assembly 1.

  [1] First, by operating the pusher connector 27 of the syringe connector 1 in an unused state (not yet connected to the first drug container 100 and the second drug container 200), each gasket 24 is operated. It is assumed that each is located at the first position. At this time, the engaging member 29 (elastic pieces 291 a and 291 b) is located on the proximal side with respect to the flange 23 of the outer cylinder 21.

  Then, as shown in FIGS. 1 and 2, the syringe assembly 1 is connected to the first drug container 100 and the second drug container 200. At this time, as described above, the first drug container 100 and the second drug container 200 are each released from the negative pressure state. Thereby, subsequent suction operation can be performed easily.

  [2] When a finger is placed on the flange 271 of the pusher coupling body 27 and the pusher coupling body 27 is pressed from the state shown in FIG. 2, the gaskets 24 in the first position are respectively moved as shown in FIG. It moves in the tip direction and exceeds the vent hole 213. At that time, in the engagement member 29, the elastic pieces 291 a and 291 b are inserted into the engagement holes 28 of the flange 23 of the outer cylinder 21, and accordingly, the inclined surfaces 293 of the claws 292 are the inner peripheral portions of the engagement holes 28. It is pressed inward by 281. As a result, the elastic pieces 291a and 291b can approach each other, so that the claws 292 can get over the engagement holes 28 and pass through the engagement holes 28.

  [3] When the pusher connector 27 is further pressed from the state shown in FIG. 3, each gasket 24 contacts the bottom 211 of the outer cylinder 21 in which the gasket 24 is inserted, as shown in FIG. 4. Touch. Accordingly, as described above, the internal pressure of the storage space 105 of each of the first drug container 100 and the second drug container 200 increases.

  At this time, the engagement member 29 of the pusher connector 27 is inserted through the engagement hole 28 of the flange 23 of the outer cylinder 21. Moreover, since the pressing force with respect to each nail | claw 292 by the inner peripheral part 281 of the engagement hole 28 is cancelled | released, the elastic pieces 291a and 291b are spaced apart similarly to the state shown in FIG.

  [4] When the state shown in FIG. 4 is turned upside down and the pressing force applied to the pusher coupling body 27 is released, the gasket 24 corresponding thereto retreats due to the increased internal pressure of each storage space 105 as described above. (See FIG. 5). Accordingly, the first chemical liquid Q1 is reliably sucked into the filling space 25 of the first syringe 2, and the second chemical liquid Q2 is reliably sucked into the filling space 25 of the second syringe 3.

  By the way, each gasket 24 retreats and tries to exceed the vent hole 213 again. At this time, each claw 292 of the engaging member 29 of the pusher coupling body 27 is engaged with the flange 23 of the outer cylinder 21. It will be engaged with the edge of the joint hole 28. As a result, the movement of each gasket 24 in the proximal direction is restricted, so that it is reliably prevented that each gasket 24 crosses the vent hole 213 again. This reliably prevents the first chemical liquid Q1 (the same applies to the second chemical liquid Q2) from leaking from the vent hole 213. That is, the engaging member 29 is a restricting means for restricting the movement of the gasket 24.

  As described above, the syringe assembly 1 is configured such that once the gasket 24 exceeds the vent hole 213, the gasket 24 is again restricted from moving beyond the vent hole 213 in the proximal direction.

  [5] Next, the syringe assembly 1 filled with the first drug solution Q1 and the second drug solution Q2 is detached from the first drug container 100 and the second drug container 200. Thereafter, for example, nozzles (not shown) are attached to the mouth portions 22 of the first syringe 2 and the second syringe 3 of the syringe assembly 1. Then, by pressing the pusher connector 27, the first chemical Q1 discharged from the mouth 22 of the first syringe 2 and the second medicine 22 discharged from the mouth 22 of the second syringe 3 are used. The chemical liquid Q2 can be batched, that is, mixed and ejected from the nozzle.

Second Embodiment
FIG. 6 is a longitudinal sectional view showing the vicinity of the syringe vent of the syringe assembly (second embodiment) of the present invention.

  Hereinafter, the second embodiment of the syringe and the syringe assembly according to the present invention will be described with reference to this figure, but the description will focus on the differences from the above-described embodiment, and the description of the same matters will be omitted.

  This embodiment is the same as the first embodiment except that a filter member is installed in the vent hole.

  In the syringe assembly 1 </ b> A shown in FIG. 6, the filter member 41 is installed in the vent hole 213 of the outer cylinder 21. The filter member 41 has a film shape and can cover the vent hole 213.

  The filter member 41 has bacteria impermeability. Thereby, when air G flows in into the outer cylinder 21 (filling space 25) via the vent hole 213, it is possible to reliably prevent bacteria from flowing in along with the air G. Thereby, the aseptic condition in the outer cylinder 21 is maintained regardless of whether the environment in which the syringe assembly 1 is used is a clean field.

  In addition, as a method of giving bacteria impermeability to the filter member 41, when the filter member 41 is a membrane type filter, an average pore diameter is set as desired. That is, the average pore diameter of the filter member 41 is preferably about 0.1 to 0.6 μm, more preferably about 0.2 μm.

  The outer cylinder 21 is also provided with a fixing member 42 that fixes the filter member 41 to the wall portion 212. The fixing member 42 has a ring shape that presses the edge portion of the filter member 41 against the wall portion 212. The fixing member 42 is fixed to the wall portion 212 of the outer cylinder 21 by a method such as adhesion (adhesion using an adhesive or a solvent) or fusion (thermal fusion, high frequency fusion, ultrasonic fusion, etc.). .

<Third Embodiment>
FIG. 7 is a side view showing the vicinity of the vent of the syringe of the syringe assembly (third embodiment) of the present invention, and FIG. 8 is a cross-sectional view taken along line AA in FIG.

  Hereinafter, the third embodiment of the syringe and the syringe assembly of the present invention will be described with reference to these drawings. However, the description will focus on the differences from the above-described embodiment, and the description of the same matters will be omitted. .

  This embodiment is the same as the first embodiment except that a plurality of protrusions are formed around the vent hole.

  In the syringe connector 1B shown in FIGS. 7 and 8, a plurality of (four in the illustrated configuration) protrusions 214 protrude from the periphery of the vent hole 213 of the wall 212 of the outer cylinder 21. Each of the protrusions 214 is not arc-shaped and is intermittently (equally spaced) arranged along the circumferential direction of the vent hole 213. Thereby, a gap 215 is formed between the adjacent protrusions 214.

  As shown in FIG. 8, when the syringe connector 1 </ b> B (outer cylinder 21) is connected to the first drug container 100 and the second drug container 200, the operator's finger (hand) mistakenly vents 213. Even if it is going to block, since each protrusion 214 is interposed between the finger and the vent hole 213, it is possible to reliably prevent the vent hole 213 from being blocked by the finger. Thereby, the air G can sequentially flow through the gaps 215 and the vent holes 213 and flow into the outer cylinder 21. Thereby, as described above, the negative pressure state of the first drug container 100 and the second drug container 200 is released, and the subsequent suction operation can be easily performed.

  Thus, each protrusion 214 prevents the vent hole 213 from being blocked by the operator's fingers when connecting the syringe assembly 1B to the first drug container 100 and the second drug container 200. It can be said that it functions as “blocking prevention means”.

  The number of protrusions 214 formed is four in the present embodiment, but is not limited to this, and may be two, three, five or more, for example.

<Fourth embodiment>
FIG. 9 is a side view showing the vicinity of the vent of the syringe of the syringe assembly (fourth embodiment) of the present invention.

  Hereinafter, the fourth embodiment of the syringe and the syringe assembly according to the present invention will be described with reference to this figure. However, the difference from the above-described embodiment will be mainly described, and the description of the same matters will be omitted.

  The present embodiment is the same as the third embodiment except that the configuration of the blocking prevention means is different.

  In the syringe assembly 1 </ b> C shown in FIG. 9, a marker (index) 216 is attached as a blocking prevention means. The marker 216 points to the vent hole 213.

  The marker 216 is attached to the periphery of the vent hole 213 of the wall 212 of the outer cylinder 21, and includes a ring-shaped portion 217 that surrounds the vent hole 213 and a name portion 218 that is described as “vent hole”. Yes. Moreover, it is preferable that the ring-shaped part 217 and the name part 218 have colors different from the scales attached to the gasket 24 and the outer cylinder 21, respectively. In addition, it does not specifically limit as a method of attaching the marker 216 to the outer cylinder 21, For example, the method by printing is mentioned.

  When connecting the syringe assembly 1 </ b> C (outer cylinder 21) to the first drug container 100 and the second drug container 200, the operator can be aware (notice) of the presence of the vent hole 213 by the marker 216. Therefore, it is possible to reliably prevent accidentally (unintentionally) blocking the vent hole 213 with the operator's finger. As a result, the air G can pass through the vent hole 213 and flow into the outer cylinder 21. Therefore, as described above, the negative pressure state of the first drug container 100 and the second drug container 200 is reduced. It is cancelled | released and subsequent suction operation can be performed easily.

<Fifth Embodiment>
FIG. 10 is a partial longitudinal sectional view showing the vicinity of the vent of the syringe of the syringe assembly (fifth embodiment) of the present invention.

  Hereinafter, the fifth embodiment of the syringe and the syringe assembly according to the present invention will be described with reference to this figure, but the description will focus on the differences from the above-described embodiment, and the description of the same matters will be omitted.

  The present embodiment is the same as the third embodiment except that the configuration of the blocking prevention means is different.

  The syringe assembly 1D shown in FIG. 10 includes a tube 51 connected to the vent hole 213 as a blocking prevention means. The vent hole 213 is formed with a protruding portion 219 whose edge protrudes outward in a cylindrical shape. One end 511 of the tube 51 can be connected to the protrusion 219. Thereby, the inside of the outer cylinder 21 and the tube 51 communicate.

  When the syringe assembly 1D is connected to the first drug container 100 and the second drug container 200, the tube 51 can prevent the vent hole 213 from being blocked by the operator's finger. As a result, the air G can sequentially pass through the tube 51 and the vent hole 213 and flow into the outer cylinder 21, and thus, as described above, the first drug container 100 and the second drug container 200. The negative pressure state is released, and the subsequent suction operation can be easily performed.

  A filter member 41 is installed in the middle of the tube 51. Thereby, when the air G passes through the inside of the tube 51, it is possible to reliably prevent bacteria from flowing into the outer cylinder 21 together with the air G.

  Further, the other end portion 512 of the tube 51 is provided with a valve 52 composed of a three-way cock. By operating this valve 52, the syringe assembly 1 </ b> D can select an air release state in which the inside of the outer cylinder 21 is open to the atmosphere and a blocking state in which the inside of the outer cylinder 21 is shut off from the atmosphere. When connecting the syringe assembly 1D to the first drug container 100 and the second drug container 200, the syringe assembly 1D can be opened to the atmosphere. Further, when a suction operation is performed on the syringe assembly 1D connected to the first drug container 100 and the second drug container 200, the syringe assembly 1D can be put into a blocked state. When the valve 52 is installed, the engagement member 29 may be omitted.

  As described above, the illustrated embodiment of the syringe and the syringe assembly of the present invention has been described, but the present invention is not limited to this, and each part constituting the syringe and the syringe assembly exhibits the same function. It can be replaced with any configuration obtained. Moreover, arbitrary components may be added.

  In addition, the syringe and the syringe assembly of the present invention may be a combination of any two or more configurations (features) of the above embodiments.

  Moreover, a syringe coupling body is not limited to a thing provided with two syringes, For example, a thing provided with three or more syringes may be sufficient.

  In addition, one vent hole is not limited to being formed in each syringe, and two or more vent holes may be formed, for example. In this case, each vent hole is formed at the same position in the longitudinal direction of the syringe.

  Further, the puncture needle is not limited to the one previously attached to each syringe, that is, the syringe-side component, and may be a connector-side component.

1, 1A, 1B, 1C, 1D Syringe connector 2 First syringe 21 Outer cylinder (syringe outer cylinder)
211 Bottom 212 Wall (pipe wall)
213 Vent hole 214 Projection 215 Gap 216 Marker (index)
217 Ring-shaped part 218 Name part 219 Protruding part 22 Mouth part (reduced diameter part)
23 Flange 24 Gasket 25 Filling space 26 Pusher (plunger rod (operation member))
27 Pusher connector 271 Flange 28 Engagement hole 281 Inner peripheral part 29 Engagement member 291a, 291b Elastic piece 292 Claw 293 Inclined surface 3 Second syringe 41 Filter member 42 Fixing member 51 Tube 511 One end part 512 Other end part 52 Valve 7 Connector 71 Mounting portion 711 Top plate 712 Wall portion 72 First connection portion 73 Second connection portion 8 Puncture needle 81 Needle body 811 Needle tip 82 Hub 9 Connecting member 91 First holding portion 92 Second holding Part 100 First drug container 101 Bottle body 102 Port part 103 Neck part 104 Plug body 105 Storage space 200 Second drug container G Air Q1 First chemical liquid Q2 Second chemical liquid

Claims (8)

A syringe connected to a liquid container having a storage space in which liquid is stored and in a negative pressure state,
A syringe outer cylinder formed at the tip and having a mouth connected to the liquid container;
A gasket that moves in a liquid-tight manner along the longitudinal direction of the inner surface of the syringe outer cylinder;
An operation member for moving the gasket,
The syringe outer cylinder is formed with a vent hole penetrating the wall portion,
The storage space communicates with a space surrounded by the syringe outer cylinder and the gasket when the mouth portion is connected to the liquid container in a state where the gasket is located on the proximal end side with respect to the vent hole. The syringe is characterized in that the negative pressure state is released when outside air flows into the enclosed space through the vent hole.   By restricting the operation member, the gasket moves in the distal direction and once exceeds the vent hole, and then restricts the gasket from moving again in the proximal direction beyond the vent hole. The syringe according to claim 1, comprising: The syringe outer cylinder has a plate-like flange formed to project at the base end thereof,
The restricting means is provided on the operation member, and engages with a part of the flange before the gasket again moves in the proximal direction beyond the vent hole, and moves toward the proximal direction of the gasket. The syringe according to claim 2, further comprising an engaging part that regulates movement. The flange is formed with a through-hole penetrating in the thickness direction,
The engaging portion has a claw that can engage with an edge portion of the through hole at a distal end portion, and is configured by a pair of elastic pieces that can approach and separate from each other.
The pair of elastic pieces are respectively positioned on the proximal end side with respect to the flange in a state where the gasket is positioned on the proximal end side with respect to the vent hole, and the gasket moves in the distal direction from the state, and the passage is performed. When crossing the pores, they approach each other and pass through the through hole, and when the gasket moves in the proximal direction and tries to cross the vent hole again, they are separated from each other and the pawls of the through hole The syringe according to claim 3, which engages with an edge.   The syringe according to any one of claims 1 to 4, wherein the vent hole is formed near a proximal end portion of the syringe outer cylinder.   The syringe according to any one of claims 1 to 5, wherein a filter member having a bacteria-impermeable property that covers the ventilation hole is installed in the ventilation hole.   The said syringe outer cylinder is provided with the obstruction | occlusion prevention means which prevents that the said vent hole is obstruct | occluded by the operator's hand, when connecting the said opening part to the said liquid container. Syringe.   A syringe assembly comprising a plurality of the syringes according to claim 1 connected in a line.

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