JP5283389B2 - Aerosol composition - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To develop a foamable aerosol composition foaming and forming a foam when sprayed onto skin etc., cooling the foam itself with a liquefied gas held in the interior of the foam, affording an ice cream-like state, providing moderate cooling effects, and sustaining the cooling time. <P>SOLUTION: The foamable aerosol composition is composed of an aqueous stock solution comprising a surfactant and the liquefied gas. The HLB of the surfactant is 12-20, and the liquefied gas is composed of dimethyl ether and a lipophilic liquefied gas. The amount of the formulated dimethyl ether is 25-55 wt.% in the aerosol composition. The amount of the formulated lipophilic liquefied gas is 2-35 wt.% in the aerosol composition. When sprayed, a part of the liquefied gas is vaporized to form the foam. The resultant foam is then frozen with the liquefied gas held in the interior of the foam and is changed into the ice cream-like state. <P>COPYRIGHT: (C)2009,JPO&amp;INPIT

Description

  The present invention relates to a foamable aerosol composition. More specifically, an aerosol composition comprising an aqueous stock solution containing a surfactant and a liquefied gas, which forms a foam when discharged, and then the foam freezes and changes into an ice cream. It relates to a foamable aerosol composition.

  Patent Document 1 discloses a technique of an aerosol composition using a mixture gas of an aqueous stock solution containing alcohol and a surfactant, liquefied petroleum gas, and dimethyl ether as a propellant. Further, Patent Document 2 discloses a technique of an aerosol composition using a mixture gas of an aqueous stock solution containing alcohol and a lanolin derivative, liquefied petroleum gas, and dimethyl ether as a propellant. Further, Patent Document 3 discloses a technique of an aerosol composition using a mixed gas of an aqueous stock solution containing a surfactant, a lower alcohol, and an oil, a liquefied petroleum gas, and dimethyl ether as a propellant. The aerosol compositions described in Patent Documents 1 to 3 are sprayed in a mist shape and foam on the application surface.

  Patent Document 4 contains 15 to 45% by weight of an aqueous raw material and 55 to 85% by weight of a liquefied gas having a boiling point of 0 ° C. or less. A liquefied gas containing an ionic surfactant and having a boiling point of 0 ° C. or lower is a combination of one or more selected from dimethyl ether, propane, isobutane and normal butane, and the aqueous base and the liquefied gas Cooling foam, characterized in that when the mixture becomes a gel, the foamed aqueous base is cooled by the heat of vaporization of the liquefied gas to form a foam with a cooling sensation. Cosmetic technology is disclosed.

Japanese Patent No. 3477632 Japanese Patent Laid-Open No. 10-182363 JP-A-11-222417 JP 2007-131539 A

  However, the aerosol compositions of Patent Documents 1 to 3 are sprayed in the form of a mist and foamed on the coating surface. However, since the discharged product foams in a wide range, defoaming is fast and the propellant is not held in the foam. As a result, there is a problem that the discharged foam does not become ice cream and the cooling feeling is not maintained.

  Moreover, although the cold-feeling foam cosmetic of patent document 4 has a cool feeling and a foam with little dripping is obtained, the discharged foam does not become ice cream shape and there exists a problem that holding time is short. is there. In addition, since the gelation of the contents also occurs at the same time, there is a considerable stickiness on the skin and the like, and there is a problem that the feeling of use is not necessarily good.

  The foamable aerosol composition of the present invention has been made in view of the above-mentioned conventional problems, and foams to form a foam when discharged onto the skin, and the foam itself is formed by a liquefied gas held inside the foam. The object is to obtain an effervescent aerosol composition that is cooled to become an ice cream, has an appropriate cooling effect, and maintains the cooling time.

  The foamable aerosol composition according to the present invention is a foamable aerosol composition comprising an aqueous stock solution containing a surfactant and a liquefied gas, wherein the surfactant has an HLB of 12 to 20, and the liquefied gas. Is composed of dimethyl ether and a lipophilic liquefied gas, and the blending amount of the dimethyl ether is 25 to 55% by weight in the aerosol composition, and the blending amount of the lipophilic liquefied gas is 2 to 35% by weight in the aerosol composition. In this case, when discharged, a part of the liquefied gas is vaporized to form a foam, and then the foam is frozen by the liquefied gas held inside the foam to change into an ice cream.

  The surfactant is preferably an ether type nonionic surfactant.

  The ether type nonionic surfactant is preferably a polyoxyethylene alkyl ether.

  The mixing ratio of the aqueous stock solution and the liquefied gas is preferably 30/70 to 65/35 (weight ratio).

  It is preferable that the lipophilic liquefied gas is an aliphatic hydrocarbon having a vapor pressure at 20 ° C. of 0.1 to 0.5 MPa and 3 to 5 carbon atoms.

  The foamable aerosol composition according to the present invention foams to form a foam when discharged onto the skin, etc., and the foam itself is cooled by the liquefied gas held inside the foam to change into an ice cream shape. A foamable aerosol composition can be obtained in which a cooling effect is obtained and the cooling time is sustained.

  The foamable aerosol composition of the present invention is a foamable aerosol composition comprising an aqueous stock solution containing a surfactant and a liquefied gas, wherein the surfactant has an HLB of 12 to 20, and the liquefied gas is , Dimethyl ether and lipophilic liquefied gas, and the blending amount of dimethyl ether is 25 to 55% by weight in the aerosol composition, and the blending amount of lipophilic liquefied gas is 2 to 35% by weight in the aerosol composition. Then, when discharged, a part of the liquefied gas is vaporized to form a foam, and then the foam is frozen by the liquefied gas held inside the foam to change into an ice cream.

  The surfactant is blended for the purpose of foaming the discharged product to form a foam, holding the liquefied gas in the foam, adjusting the time for the liquefied gas to evaporate, and making the foam into an ice cream form, etc. The

  Examples of the surfactant include POE (9) lauryl ether, POE (21) lauryl ether, POE (25) lauryl ether, POE (15) cetyl ether, POE (20) cetyl ether, and POE (30) cetyl ether. , POE (20) stearyl ether, POE (15) oleyl ether, POE (20) oleyl ether, POE (20) behenyl ether, POE (25) octyldodecyl ether, POE (20) isocetyl ether, POE (20) iso Polyoxyethylene alkyl ethers such as stearyl ether; polyoxyethylene polyoxypropylene alkyl ethers such as POE (20) POP (4) cetyl ether; monooleic acid POE (15) glyceryl, monostearic acid POE ( 5) polyoxyethylene glycerin fatty acid ester such as glyceryl; polyoxyethylene lanolin alcohol such as POE (10) lanolin alcohol, POE (20) lanolin alcohol; POE (50) hydrogenated castor oil, POE (60) hydrogenated castor oil, Polyoxyethylene hydrogenated castor oil such as POE (80) hydrogenated castor oil, POE (100) hydrogenated castor oil; hexaglyceryl monolaurate, decaglyceryl monolaurate, decaglyceryl monomyristate, decaglyceryl monostearate, decaglyceryl monoisostearate , Polyglycerol fatty acid esters such as decaglyceryl monooleate and decaglyceryl monolinoleate; POE (20) sorbitan monopalmitate, POE (20) sorbitan monostearate Polyoxyethylene sorbitan fatty acid esters such as monoisostearic acid POE (20) sorbitan, monooleic acid POE (20) sorbitan, mono coconut oil fatty acid POE (20) sorbitan; tetrastearic acid POE (60) sorbit, tetraoleic acid POE (40 ) Polyoxyethylene sorbite fatty acid ester such as sorbite, tetraoleic acid POE (60) sorbite; Nonionic ion having HLB of 12 to 20, preferably 12.5 to 19.5 such as dimethyl silicone polyoxyalkylene copolymer Surfactants and silicone surfactants can be mentioned. When HLB is smaller than 12, it is difficult to foam at the time of discharge, and it tends to be difficult to form a foam.

  Among the above surfactants, it has excellent foaming properties and is easy to be foamed when discharged, and it has excellent liquefied gas retention, and it is easy to recognize the change in surface condition when the foam is cooled to become ice cream. From the viewpoint of easily forming an ice cream, an ether type nonionic surfactant is preferable, and polyoxyethylene alkyl ether is particularly preferable.

  The blending amount of the surfactant is preferably 0.1 to 10% by weight, more preferably 0.5 to 8% by weight in the stock solution. When the blending amount of the surfactant is less than 0.1% by weight, it is difficult to form a foam, and since the holding power of the liquefied gas is weak, it is difficult to form an ice cream, and when it is more than 10% by weight, the skin It tends to remain on top and the feeling of use decreases.

  In addition, you may mix | blend another surfactant with the said surfactant for the objective of adjusting a foaming state. Examples of the other surfactant include nonionic surfactants having an HLB of less than 12, alkyl sulfates, polyoxyethylene alkyl ether sulfates, alkyl phosphates, polyoxyethylene alkyl ether phosphates, Anionic surfactants such as fatty acid soaps and α-olefin sulfonates; Cationic surfactants such as alkylammonium salts and alkylbenzylammonium salts; Amphoteric surfactants such as betaine acetate and lecithin; Polyalkylvinylpyridinium, Polymeric surfactants such as alkylphenol polymer derivatives, styrene / maleic acid polymer derivatives, copolymers of alkyl vinyl ether and maleic acid; N-coconut oil fatty acid acyl-L-glutamic acid triethanolamine, N-coconut oil fatty acid acyl -L-glutamic acid Amino acid surfactants such as thorium; silicones such as polyoxyethylene / methylpolysiloxane copolymer, polyoxypropylene / methylpolysiloxane copolymer, poly (oxyethylene / oxypropylene) / methylpolysiloxane copolymer Surfactants; and the like.

  In the aqueous stock solution, water is blended as a solvent for blending the surfactant, an active ingredient to be described later, and the like to form a foam when discharged. Examples of the water include purified water, ion exchange water, physiological saline, and deep ocean water. The water content is preferably 60 to 99.9% by weight, more preferably 70 to 99.5% by weight in the aqueous stock solution. When the blending amount of water is less than 60% by weight, it is difficult to foam, and when it is more than 99.9% by weight, the blending amount of additives such as active ingredients decreases, and it is difficult to obtain effects such as active ingredients. Tend.

  The aqueous undiluted solution used in the present invention can contain active ingredients, alcohols, oil components, water-soluble polymers, powders, and the like depending on applications and purposes.

  Examples of the active ingredient include antipruritic agents such as crotamiton and d-camphor, anti-inflammatory analgesics such as methyl salicylate, indomethacin, piroxicam, felbinac and ketoprofen; oxyconazole, clotrimazole, sulconazole, bifonazole, miconazole, isoconazole, Antifungal agents such as econazole, thioconazole, butenafine, and salts thereof such as hydrochloride, nitrate, acetate; astringents such as zinc oxide, allantoin hydroxyaluminum, tannic acid, citric acid, lactic acid; allantoin, glycyrrhetinic acid, Anti-inflammatory agents such as dipotassium glycyrrhizinate and azulene; local anesthetics such as dibucaine hydrochloride, tetracaine hydrochloride, lidocaine, lidocaine hydrochloride; diphenhydramine, diphenhydramine hydrochloride, male Antihistamines such as chlorpheniramine acid; bactericidal disinfectants such as paraoxybenzoate, sodium benzoate, potassium sorbate, phenoxyethanol, benzalkonium chloride, benzethonium chloride, chlorhexidine chloride, photosensitizer, parachlormetacresol; 1-menthol , Refreshing agents such as camphor; ethylene glycol, diethylene glycol, propylene glycol, glycerin, 1,3-butylene glycol, collagen, xylitol, sorbitol, hyaluronic acid, caronic acid, sodium lactate, dl-pyrrolidone carboxylate, keratin, casein, Moisturizers such as lecithin and urea; lauric acid methacrylate, methyl benzoate, methyl phenylacetate, geranyl crotolate, acetophenone myristate, acetic acid Deodorants such as benzyl and propionate; pest repellents such as N, N-diethyl-m-toluamide (diet) and caprylic acid diethylamide; glycine, alanine, leucine, serine, tryptophan, cystine, cysteine, methionine, asparagine Amino acids such as acid, glutamic acid, arginine; UV absorbers such as hexyl diethylaminohydroxybenzoyl benzoate, 2-ethylhexyl paramethoxycinnamate, ethylhexyl triazone, oxybenzone, hydroxybenzophenone sulfonic acid, sodium dihydroxybenzophenone sulfonate, dihydroxybenzophenone; UV scattering agents such as zinc oxide, titanium oxide, octyltrimethoxysilane-coated titanium oxide; retinol, retinol acetate, retino palmitate Vitamins such as calcium, pantothenate, ascorbic acid, sodium ascorbate, dl-α-tocopherol, tocopherol acetate, tocopherol, tocopherol nicotinate, dibenzoylthiamine, riboflavin and mixtures thereof; ascorbic acid, α-tocopherol, Antioxidants such as dibutylhydroxytoluene and butylhydroxyanisole; peony extract, loofah extract, rose extract, lemon extract, aloe extract, ginger root extract, eucalyptus extract, sage extract, tea extract, seaweed extract, placenta extract, silk extract, etc. Extractants; whitening agents such as arbutin and kojic acid; and various fragrances such as natural and synthetic fragrances.

  The amount of the active ingredient is 0.05 to 20% by weight, preferably 0.1 to 15% by weight in the aqueous stock solution. When the amount of the active ingredient is less than 0.05% by weight, the effect of the active ingredient cannot be fully exerted, and when it is more than 20% by weight, the concentration of the active ingredient becomes too high. May affect.

  The alcohols are used for the purpose of, for example, preparing a solubilizing component for blending an active ingredient that is difficult to dissolve in water, the foamability at the time of discharge, and the ease of freezing after discharge.

  Examples of the alcohols include monovalent lower alcohols having 2 to 3 carbon atoms such as ethanol and isopropyl alcohol, ethylene glycol, polyethylene glycol having a molecular weight of 50,000 or less, propylene glycol, and 1,3-butylene. Examples thereof include polyhydric alcohols such as glycol, glycerin, xylitol, sorbitol, and maltitol.

  The blending amount of the alcohols is preferably 1 to 30% by weight, more preferably 3 to 20% by weight in the aqueous stock solution. When the blending amount of the alcohol is less than 1% by weight, it is difficult to obtain the blending effect of the alcohol, and when the blending amount is more than 30% by weight, it tends to be difficult to foam.

  The oil is used for the purpose of adjusting foamability at the time of discharge and ease of freezing after discharge.

  Examples of the oil include isopropyl myristate, cetyl octanoate, octyldodecyl myristate, isopropyl palmitate, cetyl lactate, isocetyl stearate, isocetyl isostearate, diisobutyl adipate, di-2-ethylhexyl sebacate, and myristic acid- Ester oils such as 2-hexyldecyl, 2-hexyldecyl adipate, diethoxyethyl succinate, diisostearyl malate; hydrocarbons such as liquid paraffin, liquid isoparaffin, squalane, squalene, mineral oil; octamethylcyclotetra Siloxane, Decamethylcyclopentasiloxane, Dodecamethylcyclohexasiloxane, Methylcyclopolysiloxane, Tetrahydrotetramethylcyclotetrasiloxane, Octamethyl Silicone oils such as resiloxane, decamethyltetrasiloxane, methylpolysiloxane, methylphenylpolysiloxane; avocado oil, camellia oil, corn oil, mink oil, olive oil, rapeseed oil, sesame oil, castor oil, linseed oil, safflower oil, Vegetable oils such as jojoba oil, coconut oil, palm oil, soybean oil, cottonseed oil, peanut oil; 10 to 20 carbon atoms such as lauryl alcohol, myristyl alcohol, cetyl alcohol, stearyl alcohol, aralkyl alcohol, behenyl alcohol, lanolin alcohol Higher alcohols; higher fatty acids having 10 to 20 carbon atoms such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, isostearic acid; candelilla wax, beeswax, microcris Phosphorus wax, Polawax, synthetic wax, paraffin wax, jojoba wax, polyethylene wax, lanolin, waxes such as lanolin acetate; and the like.

  The blending amount of the oil is preferably 0.1 to 10% by weight, more preferably 0.5 to 8% by weight in the aqueous stock solution. When the blending amount of the oil is less than 0.1% by weight, it is difficult to obtain the effect of blending the oil, and when it exceeds 10% by weight, the foamability at the time of discharge tends to decrease.

  The water-soluble polymer is used for the purpose of increasing the viscosity of the aqueous stock solution to make it easier to hold the liquefied gas in the discharge.

  Examples of the water-soluble polymer include gums such as xanthan gum, gellan gum, carrageenan, and guar gum; celluloses such as hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethyl cellulose, nitrulose, crystalline cellulose, methyl cellulose, and ethyl cellulose; agar, dextrin, Examples include pectin, starch, gelatin, gelatin hydrolyzate, sodium alginate, modified potato starch, polyvinyl alcohol, polyvinyl pyrrolidone, and carboxyvinyl polymer.

  The blending amount of the water-soluble polymer is preferably 0.01 to 5% by weight, more preferably 0.05 to 3% by weight in the aqueous stock solution. When the blending amount of the water-soluble polymer is less than 0.01% by weight, it is difficult to obtain the above-mentioned effect. When the blending amount is more than 5% by weight, the viscosity of the stock solution becomes too high and tends to be difficult to mix with the liquefied gas. is there.

  The powder is used for the purpose of improving the feeling of use, for example, imparting a smooth feeling. Further, the powder itself can act as an active ingredient, or can be used as a carrier or an adhesive that carries other active ingredients.

  Examples of the powder include talc, zinc oxide, kaolin, mica, magnesium carbonate, calcium carbonate, zinc silicate, magnesium silicate, aluminum silicate, calcium silicate, silica, zeolite, ceramic powder, and boron nitride. can give.

  The blending amount of the powder is preferably 0.1 to 5% by weight, more preferably 0.3 to 3% by weight in the aqueous stock solution. When the blending amount of the powder is less than 0.1% by weight, it is difficult to obtain the effect of blending the powder, and when the blending amount is more than 5% by weight, the discharge holes of the valve and the discharge member are easily clogged. Further, when stored for a long time in a stationary state, the powder tends to harden at the bottom of the container (caking), making it difficult to discharge a uniform composition.

  The aqueous stock solution used in the present invention can be prepared by dissolving or dispersing a surfactant, an active ingredient blended as necessary, and the like in water. In addition, when a component that is difficult to dissolve in water or alcohols is blended, it may be emulsified.

  The liquefied gas is liquid in the aerosol container and is vaporized when discharged into the atmosphere, but when the aerosol composition of the present invention is discharged, a part of the liquefied gas is vaporized to foam the stock solution, and the rest The liquefied gas is held in the discharged material, and after a while, vaporizes, and the discharged material is cooled by the heat of vaporization to form an ice cream. Note that when the liquefied gas held in the discharged material (foam) is vaporized, the surface state of the foam changes to an ice cream shape in which the foam is frozen as it is, so that the user can recognize the change.

  Examples of the liquefied gas include hydrophilic dimethyl ether and a new oily liquefied gas. Examples of the new oily liquefied gas include propane, normal butane, isobutane, and mixtures thereof, C3-C5 aliphatic hydrocarbons, hydrofluoroethers such as methyl perfluorobutyl ether and ethyl perfluorobutyl ether, And mixtures of aromatic hydrocarbons and hydrofluoroethers. In addition, as the lipophilic liquefied gas, it is preferable to use an aliphatic hydrocarbon having a vapor pressure of 0.1 to 0.5 MPa at 20 ° C. from the viewpoint of excellent foamability and easy discharge in a foam state.

  The aerosol composition of the present invention is characterized in that a specific amount of hydrophilic dimethyl ether and a new oily liquefied gas are blended respectively.

  The dimethyl ether is retained in the discharged product, and is used for the purpose of evaporating after a while, cooling the discharged product to form an ice cream, and the blending amount thereof is 25 to 55% by weight in the aerosol composition, Preferably it is 30 to 50% by weight. When the blending amount of dimethyl ether is less than 25% by weight, the ability to cool the discharged product is weak and hardly forms an ice cream, and when it exceeds 55% by weight, foaming tends to be difficult.

  The new oily liquefied gas is used for the purpose of evaporating the discharged product by evaporating it from the aqueous stock solution at the time of discharge, and the blending amount is 2 to 35% by weight, preferably 3 to 30% by weight in the aerosol composition. %. When the blending amount of the new oily liquefied gas is less than 2% by weight, the foaming power is weak and difficult to foam, and when it exceeds 35% by weight, the discharged material tends to be cooled at the time of discharge, and tends to freeze without foaming.

  The blending ratio (weight ratio) of the dimethyl ether and the new oily liquefied gas is preferably 40/60 to 95/5, and more preferably 50/50 to 93/7. When the blending ratio is smaller than 40/60, that is, when the blending ratio of the new oily liquefied gas is more than 60% by weight in the liquefied gas, it is difficult to form an ice cream, and when it is larger than 95/5, When the blending ratio of the new oily liquefied gas is less than 5% by weight in the liquefied gas, foaming tends to be difficult.

  The aerosol composition of the present invention can be prepared, for example, by filling a pressure resistant container with an aqueous stock solution and then filling a liquefied gas with an undercup filling or the like, fixing a valve, and mixing the two.

  The mixing ratio (weight ratio) of the aqueous stock solution and liquefied gas is preferably 30/70 to 65/35, and more preferably 35/65 to 60/40. When the blending ratio is smaller than 30/75, that is, when the blending amount of the liquefied gas is more than 70% by weight in the aerosol composition, it is easy to freeze before foaming, and when it is larger than 65/35, that is, liquefaction. When the blending amount of the gas is less than 35% by weight, the cooling capacity is low and the ice cream tends to be difficult.

  The foamable aerosol composition of the present invention foams after discharge to form a foam, or is discharged in a foamed state, and after a while, the liquefied gas contained in the foam evaporates and cools the foam itself to ice cream It becomes a shape. The discharged foam retains the liquefied gas for a long time and freezes in the foamed state, so that an appropriate cooling effect is obtained and the cooling time is sustained. Therefore, for example, it can be suitably used for human body products such as sun protection, hot flash protection, astringents, antiphlogistic analgesics, antipruritics, antifungals, and burn treatments.

  EXAMPLES Hereinafter, although an Example demonstrates this invention more concretely, this invention is not limited to these.

  The evaluation method is shown below.

<Foaming properties>
The obtained aerosol composition was adjusted to 25 ° C., 0.5 g was discharged into a petri dish, and the foamed state of the discharged material was evaluated.
A: Discharged in a foamed state.
○: The liquid was discharged and then foamed.
X: It discharged in liquid form and it did not foam after that.

<State change>
The obtained aerosol composition was adjusted to 25 ° C., 0.5 g was discharged into a petri dish, and the state change of the discharged material was evaluated.
(Double-circle): It was able to confirm clearly that the surface of the foam was frozen.
○: A part of the surface of the foam was frozen.
X: The change could not be confirmed.
−: Not evaluated because it did not form.

<State of discharged material>
The obtained aerosol composition was adjusted to 25 ° C., 0.5 g was discharged into a petri dish, and the state of the discharged material was evaluated.
A: The entire foam was frozen and became ice cream.
○ 1: The degree of freezing was slightly insufficient, and a soft ice cream was formed.
○ 2: The foam was small and became a hard ice cream.
X1: As a form.
X2: Almost no foaming and frozen as it was.

<Cooling effect>
The obtained aerosol composition was adjusted to 25 ° C., and 0.5 g was discharged to the palm to evaluate the cooling feeling.
A: A moderate cooling feeling is obtained and lasts.
○ 1: The feeling of cooling is slightly weak but persists.
○ 2: The cooling feeling is slightly strong, but persists.
X1: It is hard to feel a cooling feeling.
X2: A feeling of cooling is too strong and pain is felt.

Example 1
The following aqueous stock solution was prepared, and 50 g of the aqueous stock solution was filled in an aluminum pressure vessel. 50 g of liquefied gas (a mixture of dimethyl ether and liquefied petroleum gas (* 1)) was filled by undercup filling, and an aerosol valve was crimped to the opening of the pressure vessel. Next, the aerosol container was shaken up and down to mix the aqueous stock solution and the liquefied gas to produce an aerosol composition.

<Aqueous stock solution>
POE (21) Lauryl ether (* 2) 1.0
1,3-butylene glycol 2.0
Methylparaben 0.1
Purified water 96.9
Total 100.0 (wt%)

<Aerosol composition>
Aqueous stock solution 50.0
Dimethyl ether 40.0
Liquefied petroleum gas (* 1) 10.0
Total 100.0 (% by weight)
* 1: Mixture of normal butane and isobutane The vapor pressure at 20 ° C is 0.15 (MPa)
* 2: NIKKOL BL-21 (trade name), HLB19.0, manufactured by Nikko Chemicals Co., Ltd.

Example 2
An aerosol composition was prepared in the same manner as in Example 1 except that liquefied petroleum gas (* 3) was used.
* 3: Mixture of propane, normal butane and isobutane, vapor pressure at 20 ° C is 0.25 (MPa)

Example 3
An aerosol composition was prepared in the same manner as in Example 1 except that the filling amount of the aqueous stock solution was 50% by weight, the filling amount of dimethyl ether was 45% by weight, and the filling amount of liquefied petroleum gas (* 1) was 5% by weight. did.

Example 4
An aerosol composition was prepared in the same manner as in Example 1 except that the filling amount of the aqueous stock solution was 50% by weight, the filling amount of dimethyl ether was 35% by weight, and the filling amount of liquefied petroleum gas (* 1) was 15% by weight. did.

Example 5
An aerosol composition was prepared in the same manner as in Example 1 except that the filling amount of the aqueous stock solution was 50% by weight, the filling amount of dimethyl ether was 30% by weight, and the filling amount of liquefied petroleum gas (* 1) was 20% by weight. did.

Example 6
An aerosol composition was prepared in the same manner as in Example 1 except that the filling amount of the aqueous stock solution was 50% by weight, the filling amount of dimethyl ether was 25% by weight, and the filling amount of liquefied petroleum gas (* 1) was 25% by weight. did.

Example 7
An aerosol composition was prepared in the same manner as in Example 1 except that the amount of the aqueous stock solution was 40% by weight, the amount of dimethyl ether was 48% by weight, and the amount of liquefied petroleum gas (* 1) was 12% by weight. did.

Example 8
An aerosol composition was prepared in the same manner as in Example 1 except that the filling amount of the aqueous stock solution was 40% by weight, the filling amount of dimethyl ether was 36% by weight, and the filling amount of liquefied petroleum gas (* 1) was 24% by weight. did.

Example 9
An aerosol composition was prepared in the same manner as in Example 1 except that the filling amount of the aqueous stock solution was 55% by weight, the filling amount of dimethyl ether was 36% by weight, and the filling amount of liquefied petroleum gas (* 1) was 9% by weight. did.

Reference Example 10
An aerosol composition was prepared in the same manner as in Example 1 except that the filling amount of the aqueous stock solution was 60% by weight, the filling amount of dimethyl ether was 28% by weight, and the filling amount of liquefied petroleum gas (* 1) was 12% by weight. did.

Reference Example 11
An aerosol composition was prepared in the same manner as in Example 1 except that the filling amount of the aqueous stock solution was 60% by weight, the filling amount of dimethyl ether was 36% by weight, and the filling amount of liquefied petroleum gas (* 1) was 4% by weight. did.

Example 12
An aerosol composition was prepared in the same manner as in Example 1 except that the filling amount of the aqueous stock solution was 30% by weight, the filling amount of dimethyl ether was 42% by weight, and the filling amount of liquefied petroleum gas (* 1) was 28% by weight. did.

Example 13
An aerosol composition was prepared in the same manner as in Example 1 except that the filling amount of the aqueous stock solution was 30% by weight, the filling amount of dimethyl ether was 35% by weight, and the filling amount of liquefied petroleum gas (* 1) was 35% by weight. did.

Comparative Example 1
An aerosol composition was prepared in the same manner as in Example 1, except that the amount of the aqueous stock solution was 70% by weight, the amount of dimethyl ether was 24% by weight, and the amount of liquefied petroleum gas (* 1) was 6% by weight. did.

Comparative Example 2
An aerosol composition was prepared in the same manner as in Example 1 except that the amount of the aqueous stock solution was 60% by weight, the amount of dimethyl ether was 20% by weight, and the amount of liquefied petroleum gas (* 1) was 20% by weight. did.

Comparative Example 3
An aerosol composition was prepared in the same manner as in Example 1, except that the amount of the aqueous stock solution was 30% by weight, the amount of dimethyl ether was 28% by weight, and the amount of liquefied petroleum gas (* 1) was 42% by weight. did.

Comparative Example 4
An aerosol composition was prepared in the same manner as in Example 1 except that the amount of the aqueous stock solution was 30% by weight, the amount of dimethyl ether was 63% by weight, and the amount of liquefied petroleum gas (* 1) was 7% by weight. did.

Comparative Example 5
An aerosol composition was prepared in the same manner as in Example 1, except that the amount of the aqueous stock solution was 50% by weight, the amount of dimethyl ether was 49% by weight, and the amount of liquefied petroleum gas (* 1) was 1% by weight. did.

Comparative Example 6
An aerosol composition was prepared in the same manner as in Example 1, except that the amount of the aqueous stock solution was 25% by weight, the amount of dimethyl ether was 60% by weight, and the amount of liquefied petroleum gas (* 1) was 15% by weight. did.

Example 14
An aerosol composition was prepared in the same manner as in Example 1 except that POE (25) lauryl ether (* 4) was used instead of POE (21) lauryl ether (* 2) as a surfactant.
* 4: NIKKOL BL-25 (trade name), HLB19.5, manufactured by Nikko Chemicals Co., Ltd.

Example 15
An aerosol composition was prepared in the same manner as in Example 1 except that POE (9) lauryl ether (* 5) was used instead of POE (21) lauryl ether (* 2) as a surfactant.
* 5: NIKKOL BL-9EX (trade name), HLB14.5, manufactured by Nikko Chemicals Co., Ltd.

Example 16
An aerosol composition was prepared in the same manner as in Example 1 except that POE (25) cetyl ether (* 6) was used instead of POE (21) lauryl ether (* 2) as a surfactant.
* 6: NIKKOL BC-25 (trade name), HLB18.5, manufactured by Nikko Chemicals Co., Ltd.

Example 17
An aerosol composition was prepared in the same manner as in Example 1 except that POE (15) cetyl ether (* 7) was used as a surfactant instead of POE (21) lauryl ether (* 2).
* 7: NIKKOL BC-15 (trade name), HLB15.5, manufactured by Nikko Chemicals Co., Ltd.

Example 18
An aerosol composition was prepared in the same manner as in Example 1 except that POE (20) stearyl ether (* 8) was used instead of POE (21) lauryl ether (* 2) as a surfactant.
* 8: NIKKOL BS-20 (trade name), HLB18.0, manufactured by Nikko Chemicals Co., Ltd.

Example 19
An aerosol composition was prepared in the same manner as in Example 1 except that POE (50) oleyl ether (* 9) was used instead of POE (21) lauryl ether (* 2) as a surfactant.
* 9: NIKKOL BO-50V (trade name), HLB18.0, manufactured by Nikko Chemicals Co., Ltd.

Example 20
An aerosol composition was prepared in the same manner as in Example 1 except that POE (20) POP (4) cetyl ether (* 10) was used instead of POE (21) lauryl ether (* 2) as a surfactant. .
* 10: NIKKOL PBC-34 (trade name), HLB 16.5, manufactured by Nikko Chemicals Co., Ltd.

Example 21
An aerosol composition was prepared in the same manner as in Example 1 except that decaglyceryl monolaurate (* 11) was used instead of POE (21) lauryl ether (* 2) as a surfactant.
* 11: NIKKOL Decaglyn 1-L (trade name), HLB 15.5, manufactured by Nikko Chemicals Co., Ltd.

Example 22
An aerosol composition was prepared in the same manner as in Example 1 except that decaglyceryl monostearate (* 12) was used in place of POE (21) lauryl ether (* 2) as a surfactant.
* 12: NIKKOL Decaglyn 1-50SV (trade name), HLB15.0, manufactured by Nikko Chemicals Co., Ltd.

Example 23
An aerosol composition was prepared in the same manner as in Example 1 except that POE (21) lauryl ether (* 2) was used as a surfactant instead of POE (15) glyceryl monooleate (* 13).
* 13: NIKKOL TMGO-15 (trade name), HLB14.5, manufactured by Nikko Chemicals Co., Ltd.

Example 24
An aerosol composition was prepared in the same manner as in Example 1 except that mono-coconut oil fatty acid POE (20) sorbitan (* 14) was used instead of POE (21) lauryl ether (* 2) as a surfactant.
* 14: NIKKOL TL-10 (trade name), HLB 16.9, manufactured by Nikko Chemicals Co., Ltd.

Example 25
An aerosol composition was prepared in the same manner as in Example 1 except that POE (40) lanolin alcohol (* 15) was used instead of POE (21) lauryl ether (* 2) as a surfactant.
* 15: NIKKOL BWA-40 (trade name), HLB17.0, manufactured by Nikko Chemicals Co., Ltd.

Example 26
An aerosol composition was prepared in the same manner as in Example 1 except that POE (60) hydrogenated castor oil (* 16) was used instead of POE (21) lauryl ether (* 2) as a surfactant.
* 16: NIKKOL HCO-60 (trade name), HLB14.0, manufactured by Nikko Chemicals Co., Ltd.

Example 27
An aerosol composition was prepared in the same manner as in Example 1 except that POE (100) hydrogenated castor oil (* 17) was used instead of POE (21) lauryl ether (* 2) as a surfactant.
* 17: NIKKOL HC-100 (trade name), HLB16.5, manufactured by Nikko Chemicals Co., Ltd.

Example 28
An aerosol composition was prepared in the same manner as in Example 1 except that dimethylsilicone / polyoxyalkylene copolymer (* 18) was used instead of POE (21) lauryl ether (* 2) as a surfactant.
* 18: SH3771M (trade name), HLB13.0, manufactured by Toray Dow Corning

Comparative Example 7
An aerosol composition was prepared in the same manner as in Example 1 except that POE (4.2) lauryl ether (* 19) was used instead of POE (21) lauryl ether (* 4).
* 19: NIKKOL BL-4.2 (trade name), HLB 11.5, manufactured by Nikko Chemicals Co., Ltd.

Comparative Example 8
An aerosol composition was prepared in the same manner as in Example 1 except that glyceryl monostearate (* 20) was used instead of POE (21) lauryl ether (* 4).
* 20: NIKKOL MGS-DEXV (trade name), HLB5.5, manufactured by Nikko Chemicals Co., Ltd.

  As shown in Table 1, in Comparative Example 1 and Comparative Example 2, when the amount of dimethyl ether was less than 25% by weight, the discharged product was discharged in a foamed state, but the surface did not change and became an ice cream shape. did not become. Also, it was difficult to feel the cooling feeling. In Comparative Example 3, when the blending amount of the liquefied petroleum gas exceeds 35% by weight, it was slightly foamed after being ejected in a liquid state, but was excessively cooled by the liquefied petroleum gas separated from the ejected matter, and felt pain. .

  In Comparative Example 4 and Comparative Example 6, when the blending amount of dimethyl ether is more than 55% by weight, or when the blending amount of liquefied petroleum gas is less than 2% by weight in Comparative Example 5, the discharged product is ejected in a liquid state. It was frozen as it was without foaming. The cooling feeling was so strong that it felt pain.

  In Comparative Examples 7 and 8, when the HLB of the surfactant was 12 or less, the surfactant was discharged in a liquid state and did not foam after that.

  Next, a prescription example is shown.

Formulation Example 1 (Anti-inflammatory analgesic)
The following aqueous stock solution was prepared, and 50 g of the aqueous stock solution was filled in an aluminum pressure vessel. 50 g of liquefied gas (dimethyl ether / liquefied petroleum gas (* 1) = 80/20 (weight ratio)) was filled by undercup filling, and an aerosol valve was crimped on the opening of the pressure vessel. Next, the aerosol container was shaken up and down to mix the aqueous stock solution and the liquefied gas to produce an aerosol composition.

<Aqueous stock solution>
Indomethacin 1.00
l-Menthol 0.50
1.3-Butylene glycol 2.00
POE (21) Lauryl ether (* 2) 1.00
Methylparaben 0.10
Ethanol 5.00
Purified water 90.40
Total 100.00 (% by weight)

Formulation example 2 (Itching prevention)
An aerosol composition was produced in the same manner as in Formulation Example 1 except that 50 g of the following aqueous stock solution and 50 g of liquefied gas (dimethyl ether / liquefied petroleum gas (* 1) = 90/10 (weight ratio)) were filled.

<Undiluted solution>
Diphenhydramine 1.00
Lidocaine 2.00
Glycosalicylate 5.00
l-Menthol 0.50
Dipotassium glycyrrhizinate 0.50
Urea 10.00
POE (60) hydrogenated castor oil (* 16) 1.00
Ethanol 5.00
Methylparaben 0.10
Purified water 74.90
Total 100.00 (% by weight)

Formulation Example 3 (Astringent)
An aerosol composition was produced in the same manner as in Formulation Example 1 except that 50 g of the following aqueous stock solution and 50 g of liquefied gas (dimethyl ether / liquefied petroleum gas (* 3) = 90/10 (weight ratio)) were filled.

<Undiluted solution>
Dipotassium glycyrrhizinate 0.05
l-Menthol 0.05
Aloe extract 0.05
POE (25) cetyl ether (* 6) 1.00
Talc 1.00
Ethanol 5.00
Methylparaben 0.10
Purified water 92.80
Total 100.00 (% by weight)

Formulation Example 4 (Burn treatment)
An aerosol composition was produced in the same manner as in Formulation Example 1 except that 55 g of the following aqueous stock solution and 45 g of liquefied gas (dimethyl ether / liquefied petroleum gas (* 1) = 80/20 (weight ratio)) were charged.

<Undiluted solution>
Bufexamac 0.20
Lidocaine 0.10
Acrinol 0.10
POE (21) Lauryl ether (* 2) 1.00
Zinc oxide 3.00
Ethanol 5.00
Methylparaben 0.10
Purified water 90.50
Total 100.00 (% by weight)

Formulation Example 5 (Shaving foam)
An aerosol composition was produced in the same manner as in Formulation Example 1 except that 35 g of the following aqueous stock solution and 65 g of liquefied gas (dimethyl ether / liquefied petroleum gas (* 1) = 50/50 (weight ratio)) were charged.

<Undiluted solution>
Myristic acid 4.0
Cetanol 1.0
POE (60) hydrogenated castor oil (* 16) 1.0
Mono coconut oil fatty acid POE (20) sorbitan (* 14) 1.0
Methyl polysiloxane (500 cs) 2.0
Methylparaben 0.1
Triethanolamine 5% aqueous solution 26.0
Purified water 64.9
Total 100.0 (wt%)

  As described above, according to the foamable aerosol composition of the present invention, foam is formed when ejected to the skin and the like, and the foam itself is cooled by the liquefied gas held inside the foam to become an ice cream shape. It is possible to obtain a foamable aerosol composition that has a sufficient cooling effect and that has a sustained cooling time.

Claims (6)

A foamable aerosol composition comprising an aqueous stock solution containing a surfactant and water and a liquefied gas,
The surfactant has an HLB of 12 to 20,
The water content is 60-99.9% by weight in the aqueous stock solution,
The liquefied gas comprises dimethyl ether and a lipophilic liquefied gas;
The amount of the dimethyl ether is 25 to 50 % by weight in the aerosol composition,
The blending amount of the lipophilic liquefied gas is 2 to 35% by weight in the aerosol composition ,
The mixing ratio of the aqueous stock solution and the liquefied gas is 30/70 to 55/45 (weight ratio) ,
It is discharged in the form of a foam, or forms a foam after discharging in a liquid state,
A foamable aerosol composition characterized in that the foam freezes by the liquefied gas held inside the foam and changes into an ice cream. The foamable aerosol composition according to claim 1, wherein the surfactant is an ether type nonionic surfactant. The foamable aerosol composition according to claim 1 or 2, wherein the ether type nonionic surfactant is a polyoxyethylene alkyl ether. The aqueous stock solution contains a monohydric alcohol and / or a polyhydric alcohol having 2 to 3 carbon atoms,
The foamable aerosol composition according to any one of claims 1 to 3, wherein a blending amount of the monohydric alcohol having 2 to 3 carbon atoms and / or a polyhydric alcohol is 1 to 30 wt% in the aqueous stock solution. object. The foamable aerosol composition according to any one of claims 1 to 4, wherein a mixing ratio of the aqueous stock solution and the liquefied gas is 35/65 to 55/45 (weight ratio). The vapor pressure at 20 ° C of the lipophilic liquefied gas is 0.1 to 0.5 MPa, and is an aliphatic hydrocarbon having 3 to 5 carbon atoms, according to any one of claims 1 to 5. Effervescent aerosol composition.