JP5218826B2 - Biosensor system, biosensor and biosensor measuring instrument - Google Patents

Description

  The present invention relates to a biosensor system, a biosensor, and a biosensor measuring device, specifically, a biosensor system using a biosensor provided with an automatic recognition mark.

  In recent years, biosensors that enable measurement of in-vivo substances such as blood glucose levels using enzyme reactions and antigen-antibody reactions have been developed. Such biosensors have different sensor sensitivities due to differences in the lots of enzymes used, production lines, detection electrode formation, enzyme application, etc., and the sensor sensitivities are the same among all production lots. Not necessarily. In order to calibrate the difference in sensor sensitivity, for example, the manufacturer adjusts the sensor sensitivity for each production lot and then ships a calibration sensor for adjusting the sensor sensitivity of the measuring instrument for each product package. Or assigning an identification number to each production lot. The user then calibrates the measuring instrument using the calibration sensor in advance, or selects the calibration data stored in the measuring instrument in advance by inputting the identification number and calibrates the measuring instrument. It is carried out. However, in any of the methods, the measurer himself has to calibrate, which not only gives the measurer the trouble of calibrating, but also gives rise to the problem that accurate measurement values cannot be obtained if calibration is forgotten. In addition, if the measuring device measures a plurality of target items, there is a problem that the calibration is not correctly performed due to a mistake in the calibration sensor.

  In order to solve such problems, for example, in Japanese Patent Laid-Open No. 2001-311711 (Patent Document 1), a slit for identifying information for calibration is provided in the output electrode of the biosensor, and the installation of this slit is provided. A method for automatically recognizing calibration data based on a pattern is disclosed.

  In Japanese Patent Laid-Open No. 10-332626 (Patent Document 2), a calibration electrode is provided separately from the output electrode on a substrate on which an output electrode constituting a biosensor is formed, and the output electrode and the calibration electrode are provided. Disclosed is a method for automatically recognizing calibration data selected by a closed circuit formation pattern formed between and.

  International Publication WO2003 / 76918 (Patent Document 3) discloses a biosensor in which a protrusion is provided at the tip of a substrate on which an output electrode constituting the biosensor is formed, or a protrusion is provided on the back surface of the substrate. Is disclosed. Here, the formation position of these protrusions and projections is recognized using the capacitance change of the capacitor formed on the connector for mounting the sensor, and calibration data is automatically recognized from this formation position, or the output electrode An electrode different from the output electrode is provided on the substrate on which the electrode is formed, and the position where this electrode is formed is automatically recognized by using the capacitance change of the capacitor formed between the electrode and the sensor mounting connector. Yes.

  Further, in Patent Document 3, as another method, a through hole is formed at the tip of a substrate on which an output electrode constituting a biosensor is formed, and the position of the through hole is defined as a leaf spring shape passing through the through hole. A method for recognizing using the conduction state of the position detection electrode is disclosed.

  On the other hand, after confirming that the biosensor has been inserted into the measuring instrument, a method for starting measurement of the output of the biosensor is disclosed in, for example, JP-T-08-504953 (Patent Document 4) or JP-A-2002-257782. (Patent Document 5) and JP-A-2007-232378 (Patent Document 6).

JP 2001-311711 A JP-A-10-332626 International Publication No. WO2003 / 76918 JP-T-08-504953 JP 2002-257782 A JP 2007-232378 A

  However, in order to automatically identify calibration data, a method for forming a slit in an electrode requires advanced techniques for forming the slit. In addition, it is conceivable that a slit formation failure or an electrode short-circuit is likely to occur, and a calibration data identification failure is likely to occur. Further, in the method of forming the calibration electrode and the protruding portion or the protruding portion for changing the capacity, it is necessary to form a new electrode or protruding portion after manufacturing, and there is a problem that the manufacturing process of the biosensor becomes complicated. is there.

  Further, in the method of forming the calibration electrode, the counter electrode (connector pin) that forms a closed circuit between the output electrode and the calibration electrode is formed in the connector, and the protrusion or the like is formed to change the capacitance. In the method in which the capacitor forming counter electrode corresponding to the calibration electrode is passed through the through hole and the position detecting electrode is passed through, it is necessary to provide the position detecting electrode on each connector.

  By the way, there are many technical restrictions in providing such a detection means in a connector, and there are restrictions in the number of counter electrodes etc. which can be provided in the connector mounting part of a biosensor. For this reason, it is considered that the number of calibration data to be prepared is limited, and there is a possibility that various biosensors cannot be supported. In addition, the method using a counter electrode and the method using a position detection electrode tend to cause a problem in that automatic identification cannot be performed correctly due to poor contact between the electrodes as the number of times the biosensor is used increases.

  Therefore, in view of these problems, the present inventors are able to identify biosensors by optical means such as through-holes in order to avoid technical limitations received from connectors and identification failures based on contact failures. By providing an identification mark composed of the above identification marks, light is emitted from the light emitting element in the biosensor measuring device toward the mark, and the identification mark is discriminated from the position of the received light receiving element. Proposed a method for automatic identification and filed a patent application.

  However, even if the biosensor output is measured after detecting the insertion of the biosensor as described in Patent Documents 4 to 6, the identification mark is not positioned at a predetermined position, and the identification mark is erroneously recognized. There was a problem that data was displayed incorrectly. In other words, most measuring instruments are designed to detect insertion even if the biosensor is not inserted correctly, taking into account play during insertion and alignment accuracy between the biosensor output electrode and the electrode in the connector. Often. In this case, the identification mark is read in a state where the biosensor is not completely inserted, and erroneous calibration data may be used.

  The present invention has been made in view of such background art, and the object of the present invention is not only to confirm the insertion of the biosensor, but also to confirm and identify that the biosensor has been inserted to the correct position. It is an object of the present invention to provide a biosensor system that can correctly read a sign.

  The biosensor system of the present invention is measured using a biosensor with a pair of output electrodes formed at one end and a mark that can be identified by optical means, and a biosensor measuring instrument. A first insertion detection means for detecting that a biosensor has been inserted, and a second insertion detection means for detecting further insertion of the biosensor after the detection. It is characterized by having.

  According to the present invention, since it is detected that the biosensor has been reliably inserted to the correct position, the presence or absence of the identification mark is correctly determined. Therefore, correct calibration data is selected, and erroneous measurement results are prevented from being displayed.

  Hereinafter, the present invention will be specifically described with reference to the accompanying drawings. FIG. 1 is a block diagram showing a configuration of a biosensor system of the present invention, and FIG. 2 is a schematic cross-sectional view in which a biosensor measuring instrument 1 in the biosensor system is partially broken. However, the embodiment shown below is an exemplification, and the present invention is not limited to the following embodiment, and all the modifications included in the scope of the claims and equivalents thereof are included in the present invention. It is intended to be included.

  The measuring instrument 1 has a circuit board 3 in which a connector 10 for mounting the biosensor 100 and taking out the output of the biosensor 100 is mounted in a housing 2. This measuring instrument 1 is necessary based on identification information composed of a storage unit 20 in which calibration data is stored, a detection unit 30 that detects an identification mark 160 provided on the biosensor 100, and the identification mark 160. A collation unit 40 for collating correct calibration data, a computation unit 50 for computing test values from the output of the biosensor 100 using the collated calibration data, and a display unit 60 for displaying the results of the computation unit 50 And detecting that the biosensor 100 is further inserted behind the detection of the first insertion detector 70 having the insertion detection circuit for detecting that the biosensor 100 has been inserted, and the first insertion detector 70. A second insertion detection unit 80 having an insertion detection circuit is provided.

  The detection unit 30 includes detection means for detecting an identification mark 160 provided on the biosensor 100. This detection means comprises optical means, and includes a light emitting element 31 such as a light emitting diode and a light receiving element 32 such as a photodiode that receives light emitted from the light emitting element 31 and passing through the identification mark 160.

  The illustrated measuring instrument 1 has the same number of light emitting elements 31 and 1 as the maximum number of identification marks 160 provided on the biosensor 100, that is, the maximum number of identification marks 160 necessary for identifying the identification information of the biosensor 100. Two light receiving elements 32 are provided. The number of necessary light emitting elements 31 varies depending on the number of calibration data prepared in the measuring instrument 1 in advance. For example, when the identification information of the biosensor 100 is configured by four identification marks 160, four light emitting elements 31 are provided.

  Each light emitting element 31 is mounted on the circuit board 3 disposed in the housing 2 of the measuring instrument 1 corresponding to the position of each identification mark 160, and emits light from below the biosensor 100 toward the identification mark 160. Irradiate. In other words, when the maximum number of identification marks 160 is formed on the biosensor 100, the light emitting elements 31 are mounted so that the light emitting elements 31 and the identification marks 160 have a one-to-one relationship. The detection unit 30 sequentially causes each light emitting element 31 to emit light at a constant light emission interval Δt.

  One light receiving element 32 is mounted on the circuit board 3 on the same surface as the substrate surface on which the light emitting element 31 is mounted, with the light receiving surface facing upward. Above the light emitting element 31, a light receiving portion 33 having a light receiving surface facing downward is disposed. The biosensor 100 is mounted between the light receiving element 32 and the light receiving unit 33. The light receiving unit 33 and the light receiving element 32 are optically connected by a light guide path 34 made of an optical fiber or the like. On the light receiving element 32 side of the light guide path 34, a light leakage prevention cover 35 is press-fitted and fixed to the circuit board 3, and light received by the light receiving portion 33 is reliably received by the light receiving element 32. Thus, the light emitted from the light emitting element 31 and passing through the identification mark 160 is received by the light receiving element 32 through the light guide 34 and converted into an electric signal.

  The connector 10 is electrically connected to the first connector electrode 11a and the second connector electrode 11b that are electrically connected to the output electrodes 112a and 112b of the biosensor 100, and one electrode 112b of the biosensor 100. And the third connector electrode 12 connected to the third electrode 170 and the fourth connector electrode 13 electrically connected to the third electrode 170 of the biosensor 100.

  The first connector electrode 11a and the second connector electrode 11b are connected to a measurement circuit in the calculation unit 50, and the second connector electrode 11b which is one connector electrode is grounded. The third connector electrode 12 is electrically connected to an insertion detection circuit included in the first insertion detection unit 70. The fourth connector electrode 13 is electrically connected to an insertion detection circuit included in the second insertion detection unit 80. The tips of the first connector electrode 11a, the second connector electrode 11b, the third connector electrode 12, and the fourth connector electrode 13 (connection locations with the electrodes of the biosensor 100) are insertion end faces of the biosensor 100. Are located on the same plane parallel to.

  The first insertion detection unit 70 includes voltage switching means 71 that switches the applied voltage applied to the third connector electrode 12 to a reference voltage or a ground voltage. Before the biosensor 100 is inserted, the voltage applied to the third connector electrode 12 is switched to the reference voltage. When the biosensor 100 is inserted, the third connector electrode 12 and the second connector are switched. The electrode 11b is short-circuited, and the first insertion detection unit 70 detects the insertion of the biosensor 100. When the second insertion detector 80 detects the insertion of the biosensor 100, the first insertion detector 80 switches the voltage applied to the third connector electrode 12 to the ground voltage.

  The second insertion detection unit 80 includes voltage switching means 81 that switches the applied voltage applied to the fourth connector electrode 13 to a reference voltage or a ground voltage. Before the biosensor 100 is inserted, the voltage applied to the fourth connector electrode 13 is switched to the reference voltage. When the biosensor 100 is completely inserted, the fourth connector electrode 13 and the second connector electrode 13 are connected. The connector electrode 11b is short-circuited, and the second insertion detection unit 80 detects the insertion of the biosensor 100. Then, the second insertion detector 80 outputs to the first insertion detector 70 that the insertion has been completed. In addition, the voltage applied to the fourth connector electrode 13 is switched to the ground voltage. As a result, the second connector electrode 11b, the third connector electrode 12 and the fourth connector electrode 13 are grounded, and the output of the biosensor 100 is transmitted between the first connector electrode 11a and the second connector electrode 11b. Measured.

  FIG. 3 is a schematic perspective view showing an example of the biosensor 100 used in the measuring instrument 1. As shown in FIG. 3, the biosensor 100 is formed by bonding the cover 120 and the substrate 110 with an adhesive layer 140 so as to form a sample space 130 between the cover 120, which is an insulating plate member, and the substrate 110. Have a structure. The biosensor 100 has a sample introduction port 101 connected to the sample space 130 at the tip thereof. Further, at the rear end of the sample space 130, vent holes 141 connecting the sample space 130 and the outside of the biosensor 100 are extended on both sides thereof. A pair of electrodes 111 is formed on the substrate 110 so as to face the sample space 130. The connector mounting portion 150 at the end of the substrate opposite to the sample introduction port 101 has a pair of terminals (output electrodes) 112a and 112b for taking out voltage electrically connected to the electrode 111 through the conductor path 113. Is exposed. The cover 120 is provided with a reagent layer 121 that faces the sample space 130 and reacts with a sample (specifically, a body fluid such as blood). The reagent layer 121 and the pair of electrodes 111 constitute a biosensor. An example of such a biosensor 100 is a chip in which a board member and a cover are produced by bending a plate member as described in, for example, International Publication WO2005 / 10591. However, the biosensor 100 used in the measuring instrument 1 of the present invention is not limited to the illustrated biosensor 100 having the structure shown in International Publication WO2005 / 10591.

  In an area other than the connector mounting portion 150, for example, in the illustrated case, three identification marks 160 including through holes are provided at positions penetrating the conductor path 113. The maximum number of identification marks 160 of the biosensor 100 is 4, and a circle indicated by a broken line indicates a position where one remaining identification mark 160 is to be formed. The formation position of the identification mark 160 may not be a position that penetrates one conductor path 113 as shown unless it is a position that affects the measurement result, for example, a position that does not penetrate the reagent layer 121 or the sample space 130. It does not matter even if the position crosses the two conductor paths 113. Further, from the viewpoint of the strength of the biosensor 100, a position passing through the three layers of the cover 120, the adhesive layer 140, and the substrate 110 is preferable, but an identification mark 160 is provided on the substrate 110 exposed when inserted into the connector 10. Also good. In order to reduce the influence on the measurement value, it is desirable to provide in a non-conductor path forming region such as between the two conductor paths 113.

The presence or absence of the identification mark 160 constitutes identification information (bit pattern) for automatically recognizing calibration data necessary for calibration. That is, an identification mark (bit pattern) in which the presence or absence of the identification mark 160 is indicated by a binary value is formed, and this identification mark determines calibration data used for calibration. For example, in the case of the identification mark 160 made of a through hole, the ON / OFF electrical signal output from the light receiving element 51 forms a bit pattern. An ON electrical signal is obtained at a position where the through hole (identification mark 160) is formed, and an OFF electrical signal is obtained at a position where there is no through hole. Then, the ON and OFF electrical signals obtained corresponding to the positions of the light emitting elements 31 sequentially emitted constitute a bit pattern, and necessary calibration data is determined from the constituted bit pattern. In other words, in the identification mark 160 formed of a through hole, the position where the through hole is formed indicates a bit pattern, and necessary calibration data is determined from the bit pattern. The position and number of the identification marks 160 vary depending on the production lot of the biosensor 100, and the identification marks 160 are formed by stamping or drilling after a trial test after production. The maximum number of identification marks 160 differs depending on the number of calibration data prepared in advance in the measuring instrument 1, and for example, if the calibration data prepared in the measuring instrument 1 is 3 (= 2 ² −1) types. If a maximum of two identification marks 160 are formed, and 15 (= 2 ⁴ −1) calibration data are prepared, a maximum of four identification marks 160 are formed.

  The biosensor 100 includes a third electrode 170 that is electrically connected to the fourth connector electrode 13. The third electrode 170 is electrically connected to the second output electrode 112b. The illustrated third electrode 170 is formed to protrude in the width direction of the second output electrode 112b. The end of the third electrode 170 on the sensor insertion side is located at a position farther from the sensor insertion side than the end of the second output electrode 112b on the sensor insertion side (opposite insertion side). That is, the third electrode 170 is formed integrally with the second output electrode 112b, and is formed in a convex shape in plan view as a whole. Accordingly, the connection between the fourth connector electrode 13 and the third electrode 170 is delayed from the connection between the third connector electrode 12 and the second output electrode 112b, and the first insertion detection unit 70 inserts the biosensor 100. After the detection, the second insertion detection unit 80 detects that the biosensor 100 is further inserted. When the second insertion detection unit 80 does not detect the insertion of the biosensor 100 within a predetermined time after the first insertion detection unit 70 detects the biosensor 100, the second insertion detection unit 80 Then, an alarm indicating that the biosensor 100 is insufficiently attached is issued, or a display to that effect is displayed on the display unit 60 to prompt the biosensor 100 to be reinserted.

  The sensor insertion side end of the third electrode 170 is positioned with reference to the position where the biosensor 100 is completely inserted. At this time, the gap (so-called play) at the tip when the biosensor 100 is inserted into the connector 10, the alignment accuracy between the second output electrode 112 b and the third connector electrode 12, the position where the identification mark 160 is formed, and the like are taken into consideration. . If the sensor insertion side end of the third electrode is close to the sensor insertion side end of the second output electrode 112b, even if the biosensor 100 is incompletely inserted, the second insertion detector detects the insertion. This is because the identification mark 160 is determined after detection. That is, when the first insertion detection unit 70 detects the insertion, the second insertion detection unit 80 does not detect the insertion, and the biosensor 100 is further inserted to a position where the identification mark 160 can be correctly identified. The second insertion detection unit 80 needs to detect the insertion of the biosensor 100.

  Thus, when the biosensor 100 is inserted into the measuring instrument 1, first, the first output electrode 112a and the first connector electrode 11a are connected, and at the same time, the second output electrode 112b and the second connector electrode 11b are connected. And the 3rd connector electrode 12 connects. At this time, since the reference voltage is applied to the third connector electrode 12, the second connector electrode 11b and the third connector electrode 12 are short-circuited, and the first insertion detector 70 is a biosensor. 100 insertions are detected. At this time, the second connector electrode 11b and the fourth connector electrode 13 are not short-circuited, and the second insertion detector 80 cannot detect the insertion of the biosensor 100. When the biosensor 100 is further inserted, the fourth connector electrode 13 and the third electrode 170 are connected. At this time, since the reference voltage is applied to the fourth connector electrode 13, the second connector electrode 11b and the fourth connector electrode 13 are short-circuited, and the second insertion detection unit 80 is a biosensor. Detect that 100 is correctly inserted. The voltage switching means 81 switches the voltage applied to the fourth connector electrode 13 from the reference voltage to the ground voltage. The second insertion detection unit 80 outputs to the first insertion detection unit 70 that the insertion of the biosensor 100 has been detected, and the first insertion detection unit 70 uses the voltage switching means 71 to output the third connector electrode 12. The voltage applied to is switched from the reference voltage to the ground voltage.

  Next, if the second insertion detection unit 80 detects the insertion of the biosensor 100, the detection unit 30 sequentially emits the four light emitting elements 52 at a constant time interval. Then, the light receiving element 32 receives the light that has passed through the identification mark 160, and the detection unit 30 has a bit pattern composed of an electrical signal corresponding to the position where the identification mark 160 is present, and the biosensor 100 shown in FIG. , And a bit pattern consisting of ON, OFF, ON, ON, for example, are detected. Then, the collation unit 40 refers to the calibration data corresponding to the bit pattern from the storage unit 20 and outputs it to the calculation unit 50. The calculation unit 50 corrects the output of the biosensor 100 based on the output calibration data and outputs the measurement result to the display unit 60.

  As described above, the biosensor system of the present invention further includes the second insertion detection unit 80 that detects the insertion of the biosensor 100 after the first insertion detection unit 70 detects the insertion of the biosensor 100. In addition, measurement in a state where the biosensor 100 is not sufficiently inserted is not performed, and display of an erroneous measurement value is prevented. In addition, if the insertion is insufficient, it can be notified that the insertion is insufficient, and a user-friendly system is provided.

  FIG. 4 is a block diagram showing a configuration of a biosensor system according to another embodiment of the present invention. This system has substantially the same configuration as the system shown in FIG. 1, and only the configuration of the electrode of the Io sensor 100 and the configuration of the connector electrode of the biosensor measuring instrument 1 are different. The insertion side end of the third electrode 170 of the biosensor 100 shown in FIG. 4 is at the same position as the insertion side end of the second output electrode 112b, and the third electrode 170 and the second output electrode 112b As shown in FIG. On the other hand, the position where the fourth connector electrode 13 of the second insertion detection unit 80 is connected to the third electrode 170 is that the first connector electrode 11a, the second connector electrode 11b, and the third connector electrode 14 are connected. It is inside the connector on the back side of the connector with respect to the position where the output electrodes 112a and 112b are connected. Also with this configuration, the second insertion detection unit 80 can detect that the biosensor 100 is further inserted behind the detection of the first insertion detection unit 70. In this way, it is possible to detect that the biosensor 100 is further inserted to the correct position by changing the relative positions of the third electrode 170 and the fourth connector electrode 13 provided in the biosensor 100.

  However, the shape of the third electrode 170 is not limited as long as the second insertion detection unit 80 can detect the second insertion detection unit 80 later than the detection of the first insertion detection unit 70. For example, as shown in FIG. 5, the third electrode 170 may be formed in a rectangular shape in plan view, and the third electrode 170 may be a common electrode with the second output electrode 112b.

  The third electrode 170 shown in FIG. 6 is formed in a substantially rectangular shape without being electrically connected to the pair of output electrodes 112a and 112b. In addition to the connector electrodes 11a and 11b connected to the output electrodes 112a and 112b, the connector 10 includes a third connector electrode 12 and a second insertion detector 80 connected to the detection circuit of the first insertion detector 70. A fourth connector electrode 13 connected to the detection circuit of the first insertion detection unit, and a fifth connector electrode 14 connected in common to the detection circuit of the first insertion detection unit 70 and the detection circuit of the second insertion detection unit 80. ing. The tip end of the fourth connector electrode 13, that is, the connection position with the third electrode 170 is on the back side of the connector 10 with respect to the connection position of the third connector electrode 12 or the fifth connector electrode 14.

  When the biosensor 100 is inserted, the third connector electrode 12 and the fifth connector electrode 14 are short-circuited by the third electrode 170, and the first insertion detection unit 70 first detects the insertion of the biosensor 100. . When the biosensor 100 is further inserted, the fourth connector electrode 13 and the fifth connector electrode 15 are short-circuited, and the second insertion detection unit 80 is delayed after the detection by the first insertion detection unit 70. It can be detected that the biosensor 100 is inserted. As described above, it is possible to detect that the biosensor 100 is completely inserted by providing the third electrode 170 independent of the output electrode 112a and the output electrode 112b. Although not shown, for example, a convex third electrode 170 as shown in FIG. 1 or a third electrode with a cut-out corner is provided, and the position to be connected to the fourth connector electrode 13 is set at the third position. You may make it position on the opposite side to a sensor insertion side rather than the position connected with the connector electrode 12 or the 5th connector electrode 14. FIG.

  In the above method, the case where a plurality of light emitting elements 31 and one light receiving element 32 are used is illustrated, but the individual light receiving elements 32 are arranged in a one-to-one relationship with each light emitting element 31, or an array It is also possible to arrange a light receiving array in which the light receiving elements are arranged and the position information received can be detected. In this case, it is not necessary for the light emitting elements 31 to emit light sequentially at a constant time interval Δt, and all the light emitting elements 31 can emit light simultaneously. However, in this case, if the light emitting elements 31 are close to each other, the light receiving element 32 corresponding to the position where the identification mark 160 is not formed may receive light and misidentify the identification information. It is advisable to take preventive measures to avoid misrecognition, such as setting an offset that is detected as ON. In addition, the light emission wavelength of the light emitting element 31 and the light receiving wavelength of the light receiving element 32 corresponding to the light emitting element 31 can be made different from each other to prevent erroneous recognition.

  In the present invention, various types of biosensors can be applied as long as they have not only the identification mark 160 made of a through-hole but also an identification mark that can be detected by optical means. FIG. 7 is a schematic sectional view in which another biosensor measuring instrument 1 applicable to the biosensor system of the present invention is partially broken. The light emitting element 31 and the light receiving element 32 are arranged on the same substrate surface of the circuit board 3. Each light emitting element 31 emits light toward the identification mark 160 formed on the back surface of the biosensor 100, and each light receiving element 32 receives the light reflected by the identification mark 160.

  FIG. 8 is a rear view of the biosensor 100 used in the measuring instrument 1. In this biosensor 100, an identification mark 160 is formed in a marker forming region 151 provided on the back surface of the substrate 110. The identification mark 160 includes three light reflective identification marks 160a having high light reflectivity and one low light reflective identification mark 160b having low light reflectivity. The light reflective identification mark 160a can be formed by, for example, applying a light reflective material or sticking a seal. The area where the substance is not applied or the sticker is not applied is recognized as a light low-reflectivity mark 161b (indicated by a broken-line square frame in the figure).

  The light emitted from the light emitting element 31 is reflected by the light reflective identification mark 160a, received by the light receiving element 32, and converted into an electric signal. In this way, the detection unit 30 recognizes the electrical signal output from the light receiving element 32 as a bit pattern and determines necessary calibration data.

  Also in this measuring instrument 1, the same number of light emitting elements 31 and one light receiving element 32 as the maximum number of identification marks 160 or the same number of light receiving elements 32 as the maximum number of light emitting elements 31 and identification marks 160 are arranged for a certain time. A configuration in which the light emitting elements 31 are caused to emit light sequentially at intervals is employed.

  In the present invention, it is preferable to form the identification mark 160 in a region other than the connector mounting portion 150 inserted into the connector 10. Thereby, the technical restrictions by the connector 10 decrease. In addition, since the biosensor 100 is reliably inserted, the small identification mark 160 is reliably identified. Accordingly, a large number of identification marks 160 can be formed, and it is possible to easily cope with diversification of the biosensor 100, for example, when the number of detection targets is increased or the amount of information such as a manufacturing lot number is increased.

It is a block diagram which shows an example of a structure of the biosensor system of this invention. It is the schematic sectional drawing which fractured | ruptured the measuring device in the biosensor system of FIG. It is a schematic perspective view of the biosensor used for the biosensor system of FIG. It is a block diagram which shows the structure of the biosensor system which is another embodiment of this invention. It is a schematic plan view of the other biosensor used for the biosensor system of FIG. It is a block diagram which shows an example of a structure of the biosensor system of this invention. It is the schematic sectional drawing which fractured | ruptured partially the measuring device applicable to the biosensor system which is another embodiment of this invention. It is a rear view of the biosensor used for the measuring device of FIG.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Measuring instrument 2 Case 3 Circuit board 10 Connector 11a 1st connector electrode 11b connected with the output electrode of a biosensor 2nd connector electrode 12 connected with the output electrode of a biosensor Detection of the 1st insertion detection part Third connector electrode 13 connected to the circuit Fourth connector electrode 30 connected to the detection circuit of the second insertion detection unit 30 detection unit 40 verification unit 50 calculation unit 60 display unit 70 first insertion detection unit 80 first 2 Insertion Detection Unit 100 Biosensor 110 Substrate 112a First Output Electrode 112b Second Output Electrode 113 Conductor Path 120 Cover 150 Connector Mounting Unit 160 Identification Mark 160a Light Reflective Identification Mark 160b Light Low Reflective Identification Mark 170 Third electrode for detecting biosensor insertion

Claims (8)

A biosensor to which a pair of output electrodes formed at one end and a mark that can be identified by optical means are attached, and a biosensor system that performs measurement using a biosensor measuring device. ,
First insertion detecting means for detecting that a biosensor has been inserted;
A biosensor system comprising second insertion detecting means for detecting that a biosensor is further inserted after the detection. A biosensor having a pair of output electrodes formed at one end, an identification mark comprising a mark that can be identified by optical means, and a third electrode electrically connected to one of the output electrodes; A biosensor system that performs measurement using a sensor measuring instrument,
The biosensor measuring instrument is
A pair of connector electrodes electrically connected to the pair of output electrodes when a biosensor is inserted;
A third connector electrode electrically connected to an output electrode to which the third electrode is electrically connected when a biosensor is inserted;
After the output electrode and the third connector electrode are connected, further comprising a connector having a fourth connector electrode that is electrically connected to the third electrode by inserting a biosensor,
First insertion detection means for detecting connection of the third connector electrode and the output electrode to detect insertion of a biosensor;
Second insertion detecting means for detecting connection of the third electrode and the fourth connector electrode and detecting further insertion of a biosensor after detection of the first insertion detecting means; A biosensor system comprising: A biosensor having a pair of output electrodes formed at one end, an identification mark comprising a mark that can be identified by optical means, and a third electrode that is not electrically connected to both of the output electrodes; A biosensor system for measuring using a biosensor measuring instrument,
The biosensor measuring instrument is
A pair of connector electrodes electrically connected to the pair of output electrodes when a biosensor is inserted;
A third connector electrode that electrically connects to the third electrode when a biosensor is inserted;
A fourth connector electrode electrically connected to the third electrode by inserting a biosensor after the third electrode and the third connector electrode are connected;
A first detection circuit for detecting insertion of a biosensor with the third connector electrode is formed, and a second detection circuit for detecting insertion of the biosensor with the fourth connector electrode is formed. A connector having a fifth connector electrode;
First insertion detection means for detecting insertion of a biosensor from the first detection circuit;
Second insertion detecting means for detecting that a biosensor is further inserted behind the detection by the first insertion detecting means from the second detection circuit;
A biosensor system comprising: 3. The third electrode according to claim 2, wherein the third electrode having a connection position between the fourth connector electrode and the fourth connector electrode is formed on the opposite side of the connection position between the third connector electrode and the output electrode. The biosensor system described. The 4th connector electrode in which the connection position of the said 3rd electrode is located in the connector back side rather than the connection position of the said 3rd connector electrode and the said output electrode is characterized by the above-mentioned. Biosensor system. A biosensor used in the biosensor system according to claim 2,
A pair of output electrodes formed at one end;
An identification mark comprising a mark that can be identified by optical means;
A third electrode electrically connected to one of the output electrodes;
The biosensor according to claim 1, wherein an insertion side end of the third electrode is located on a side opposite to the insertion side than an insertion side end of the output electrode. A biosensor having a pair of output electrodes formed at one end, an identification mark comprising a mark that can be identified by optical means, and a third electrode that is electrically connected to one of the output electrodes A biosensor measuring instrument for measuring
A pair of connector electrodes electrically connected to the pair of output electrodes when a biosensor is inserted;
A third connector electrode electrically connected to any one of the output electrodes when a biosensor is inserted;
A connector having a fourth connector electrode electrically connected to the third electrode by inserting a biosensor after the output electrode and the third connector electrode are connected;
First insertion detection means for detecting connection of the third connector electrode and the output electrode to detect insertion of a biosensor;
And a second insertion detecting means for detecting that a biosensor is further inserted behind the detection of the first insertion detecting means by the third electrode and the fourth connector electrode. Biosensor measuring instrument. A bio that has a connector mounting region in which a pair of output electrodes are formed at one end, an identification mark made of a mark that can be identified by optical means, and a third electrode that is not electrically connected to the output electrode A biosensor measuring device for measuring using a sensor,
A pair of connector electrodes electrically connected to the pair of output electrodes when a biosensor is inserted;
A third connector electrode that electrically connects to the third electrode when a biosensor is inserted;
A fourth connector electrode electrically connected to the third electrode by inserting a biosensor after the third electrode and the third connector electrode are connected;
A first detection circuit for detecting insertion of a biosensor with the third connector electrode is formed, and a second detection circuit for detecting insertion of the biosensor with the fourth connector electrode is formed. A connector having a fifth connector electrode;
First insertion detection means for detecting insertion of a biosensor from the first detection circuit;
Second insertion detecting means for detecting that a biosensor is further inserted behind the detection by the first insertion detecting means from the second detection circuit;
A biosensor measuring instrument comprising:

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