JP4963053B2 - Joint for extracorporeal circulation module and medical adapter using the joint - Google Patents

Description

  The present invention relates to an extracorporeal circulation module joint and a medical adapter for fluid-tightly connecting a liquid port of an extracorporeal circulation module and a medical tube.

  Extracorporeal circulation module used for extracorporeal circulation treatment of body fluid represented by blood and plasma, for example, artificial kidney, hemofiltration dialyzer, blood filter, plasma component separator, plasma separator, leukocyte remover, blood component adsorber And the like include one or more liquid ports for circulating body fluids and passing water and aqueous solutions.

  These fluid ports can be used for physiologic fluid flow, body fluid circulation, or dialysate flow for priming of the extracorporeal circulation module and recovery of bodily fluids when performing extracorporeal circulation treatment of bodily fluids. Used.

  Conventionally, in order to circulate dialysate through a dialyzer, a circuit having a Hansen type coupler that can be coupled to a port on the dialysate side of the dialyzer has been used. This coupler can be connected to a port having a structure conforming to the standards of the International Organization for Standardization (ISO), as described in Non-Patent Document 1, and can flow in and out dialysate from a dialyzer. Made and widely used. However, couplers used in dialysis are generally made of stainless steel and have not been disposable. In addition, some of them are made of resin, but they are not usually thrown away, and when used again, they have to be washed and sterilized. In addition, these couplers have a problem in that the structure itself is complicated, so that careful sterilization must be performed in order to suppress the growth of bacteria, and the cost is inevitably high.

  Patent Document 1 describes a nipple used when connecting various secondary coupling components including a Hansen coupling, which can be used attached to an extracorporeal circulation module used for dialysis and / or filtration. ing. That is, a nipple used when connecting to a plurality of secondary coupling components, wherein the outer surface of a hollow cylindrical member extending in the longitudinal direction having an inner surface, an outer surface, an inner surface end and an outer surface end is the outer surface. A hollow cylindrical member including a recess, wherein the outer recess is adapted to engage with a Hansen secondary coupling component including a locking device engaged with the outer recess, and further extends in the longitudinal direction. A nipple including a screw device disposed between the recess and the outer end, the screw device being adapted to engage a corresponding threaded secondary coupling component. Yes.

  Specifically, the nipple has a structure in which the tip of the liquid port is threaded so that it can be connected to a commonly used Hansen coupler and can be connected to a dedicated device. Therefore, a joint for an extracorporeal circulation module that can be engaged with the screw structure of the tip portion can be produced and coupled with a liquid port, and the joint structure for an extracorporeal circulation module is also described.

  However, the screw structure at the tip of the liquid port has a problem in that it has a large surface area that touches the outside, so that it is likely to be attached and contaminated with various germs, and is difficult to remove when contaminated or contaminated. Furthermore, since the joint for an extracorporeal circulation module that is coupled using the screw structure at the tip of the liquid port described in Patent Document 1 is located at the tip, a force is applied to the joint for the extracorporeal circulation module and the extracorporeal circulation module body. When added, the strength is weak compared to the one that is connected to the base of the liquid port, the connector is likely to come off, and it is not sufficient in terms of safety.

  In Patent Document 2, it is easy to plug and unplug, when it does not directly contact the liquid port at the time of sealing and unplugging, and when the internal pressure of the container increases during sterilization or transportation, A sealing structure for a liquid port of an extracorporeal circulation module capable of completely preventing leakage of internal liquid due to plug omission and the like, and an extracorporeal circulation module having such a sealing structure are described.

  That is, a sealing structure for the liquid port of the extracorporeal circulation module, comprising a cylindrical wall as a liquid port formed in the extracorporeal circulation module, and a plug body sealed in a sealed state on the cylindrical wall, The outer peripheral surface of the cylindrical wall is formed with ridges in a direction perpendicular to the axis, and the plug body is composed of a top plate and a cylindrical body connected to the top plate, and the back surface of the top plate is sealed when the sealing is performed. A cylindrical sealing body to be inserted in a sealed state is integrally formed on the inner peripheral surface of the cylindrical wall, and a plug body is provided on the inner peripheral surface of the cylindrical body for sealing the intruding portion of the protrusion and sealing. A sealing structure for a liquid port of an extracorporeal circulation module is disclosed, in which a concave groove is formed in which a protruding line that has entered the intruding portion enters when it rotates.

  However, Patent Document 2 considers only sealing the liquid in the extracorporeal circulation module, and does not have a structure that considers introduction or derivation of external liquid. In addition, Patent Document 2 does not describe or suggest any structure regarding the introduction or derivation of an external liquid. Furthermore, the use at high pressure and negative pressure applied during dialysis and filtration is naturally not assumed, and there is no description or suggestion.

  Patent Document 3 discloses an extracorporeal circulation module that can prevent contamination, and has no plug omission or liquid leakage during sterilization or transportation and storage, a liquid port sealing structure for an extracorporeal circulation module, and a sealing structure. Is described.

  That is, two housings are connected to the sealing member via a hinge portion, and the sealing member has two cylindrical sealing bodies projecting downward from the bottom of the top plate, and a pressing member is formed on the top surface. There is disclosed a plug body in which one housing has a sandwiching portion and a protruding portion formed on an inner wall surface, an engaging protruding portion is formed on one housing portion, and an engaging groove portion is formed on the other housing portion.

  However, Patent Document 3 also considers only sealing the liquid in the extracorporeal circulation module, and does not have a structure that considers introduction or derivation of external liquid. Further, Patent Document 3 does not describe or suggest any structure regarding the introduction or derivation of the external liquid. Furthermore, the use at high pressure and negative pressure applied during dialysis and filtration is naturally not assumed, and there is no description or suggestion.

  Furthermore, the joint between the module and the circuit is an international standard in the case of an artificial kidney, so it can be connected in a liquid-tight manner no matter how a commercially available circuit or module is selected. Modules and circuits used for filtration, hemofiltration dialysis, plasma exchange, double filtration plasmapheresis, plasma adsorption that selectively adsorbs specific proteins in plasma, etc. The shape of the nozzle varies. In particular, nozzles having a structure conforming to the International Organization for Standardization (ISO) standard (Non-Patent Document 1) are standardized for connection with Hansen couplers, but the other parts have a wide variety of structures. Therefore, when a device is determined, there is a difficulty that only modules suitable for the device can be used.

  As described above, the fluid port of the extracorporeal circulation module and the joint for extracorporeal circulation module can be joined easily, safely and inexpensively, and can be used at high pressure and negative pressure applied during dialysis and filtration. However, there has been no medical adapter that can be fitted to various devices and joints for extracorporeal circulation modules that fluidly connect the fluid port of the extracorporeal circulation module and the medical tube.

DRAFTINTERNATIONAL STANDARD ISO / DIS 8637 [§4.4.4, §4.4.5, §5.5.5, §5.5.6, page 15 Figure 3]

Japanese Patent Laid-Open No. 04-211794 JP 2002-172161 A JP 2005-192788 A

  In view of the above-mentioned problem occurring in the extracorporeal circulation module joint that fluid-tightly connects the liquid port of the extracorporeal circulation module and the medical tube, it is easy to join and separate the extracorporeal circulation module joint, The possibility of direct contact with the fluid port during joining and separation can be reduced as much as possible, and when the internal pressure of the container rises or falls during priming, body fluid collection, body fluid circulation, dialysate perfusion, etc., the connector comes off. To provide an external circulation module joint of a liquid port of an extracorporeal circulation module that can completely prevent leakage of internal liquid due to, for example, and that can be inexpensive and disposable, and a medical adapter that fits into various devices. With the goal.

  As a result of diligent research to solve the above-mentioned problems, the present inventors have found a structure of a joint for an extracorporeal circulation module comprising a coupler having a split cylinder with a hinge portion and a lock nut, thereby completing the present invention. It has come.

That is, the first configuration of the extracorporeal circulation module joint according to the present invention includes an extracorporeal circulation module joint connected to an extracorporeal circulation module liquid port conforming to the ISO8637 standard having an open cylindrical portion communicating with the inside of the extracorporeal circulation module. The extracorporeal circulation module joint includes a coupler connectable to an outer wall of the extracorporeal circulation module liquid port and a lock nut fitted into the coupler, and the coupler is coupled to each other via a hinge portion. A split cylinder having an upper plate at the end, and an inner cylinder / outer pipe that can be connected to a medical tube and communicated with the opening of the liquid port for the extracorporeal circulation module. An annular protrusion on the inner peripheral surface of the body so as to enter the annular groove on the base end side of the extracorporeal circulation module liquid port when connected to the extracorporeal circulation module liquid port And a protrusion is formed on the outer peripheral surface of the split cylinder, and a protrusion formed on the outer peripheral surface of the coupler when the coupler is fitted and rotated on the inner peripheral surface of the locking nut. It is characterized in that a concave groove is formed so that can enter.

  The second configuration of the joint for extracorporeal circulation module according to the present invention is characterized in that, in the first configuration, the inner cylinder outer tube is formed integrally with the medical tube.

According to a third configuration of the joint for extracorporeal circulation module according to the present invention, in the first and second configurations, the inner diameter of the lock nut is gradually increased toward the liquid port proximal end side of the extracorporeal circulation module. It has an inclined structure that widens, and has an inclined structure that the outer diameter of the coupler gradually increases toward the liquid port proximal end side of the extracorporeal circulation module.

The fourth configuration of the extracorporeal circulation module joint according to the present invention is characterized in that, in the first to third configurations, the coupler is made of a soft resin.

A fifth configuration of the extracorporeal circulation module joint according to the present invention is characterized in that, in the first to fourth configurations, the split cylinder is a cylinder divided into two.

In the first configuration of the medical adapter according to the present invention, two or more spaced ridges are formed on the same circumference in the direction perpendicular to the axis of the outer peripheral surface of the cylindrical portion of the liquid port for the extracorporeal circulation module. The extracorporeal circulation module liquid port structure is provided at one end of the medical tube, and the other end has the first to fifth configurations of the extracorporeal circulation module joint.

The second configuration of the medical adapter according to the present invention includes an extracorporeal circulation module liquid port structure in which ridges are formed in a direction oblique to the axis of the outer peripheral surface of the cylindrical portion of the extracorporeal circulation module liquid port. The medical tube has one end, and the other end has the first to fifth configurations of the extracorporeal circulation module joint.

The third configuration of the medical adapter according to the present invention has an extracorporeal circulation module liquid port structure in which a male screw is formed on the outer peripheral surface of the cylindrical portion of the extracorporeal circulation module liquid port, It has the 1st- 5th structure of the coupling for extracorporeal circulation modules.

  According to the present invention, it is easy to join and separate the extracorporeal circulation module joint, there is no direct contact with the liquid port during close joining and separation, etc., and priming, body fluid recovery, body fluid circulation, When the internal pressure of the container rises or falls during dialysis fluid perfusion, etc., it is possible to completely prevent leakage of internal liquid due to detachment of the joint for the extracorporeal circulation module, etc., and an inexpensive and disposable extracorporeal circulation module. A joint for a fluid port extracorporeal circulation module and a medical adapter that mates with various devices is obtained.

An embodiment of a joint for extracorporeal circulation modules and a medical adapter using the joint according to the present invention will be specifically described with reference to the drawings. FIG. 1 is a side view for explaining a state where the extracorporeal circulation module joint according to the present invention is connected to the extracorporeal circulation module liquid port, and FIG. 2 is an embodiment in which the extracorporeal circulation module joint according to the present invention is used as a medical adapter. FIG. 3A is a sectional side view showing the configuration of the first embodiment of the joint for extracorporeal circulation module and the liquid port for extracorporeal circulation module according to the present invention, and FIG. FIG. 4A is a cross-sectional side view showing the configuration of the second embodiment of the joint for extracorporeal circulation module and the liquid port for extracorporeal circulation module according to the present invention, and FIG. 2 a perspective view of the coupler of the embodiment, FIG. 5 (a) is a cross-sectional side view illustrating a first reference examples and configuration of the fluid ports for extracorporeal circulation module fitting for a body out of circulation module, FIG. 5 (b) first reference examples of Kapu Perspective view, FIGS. 6 (a) is a sectional side view showing a second reference examples and configuration of the fluid ports for extracorporeal circulation module fitting for a body out of circulation module, and FIG. 6 (b) is a perspective of the coupler of the second reference example FIGS. 7A to 7C are portions showing various embodiments of the liquid port for other extracorporeal circulation module attached to the circuit side tip of the medical adapter shown in FIG. It is a cross-sectional side view.

  The extracorporeal circulation module 15 shown in FIGS. 1 and 2 is, for example, an artificial kidney containing a hollow fiber or the like therein, and includes an inlet 30 and an outlet 31 for blood and the like in the axial direction, near both ends of the cylinder. Is provided with an extracorporeal circulation module liquid port (hereinafter simply referred to as “liquid port”) 1 that serves as an inlet and outlet for other fluids such as dialysate. The liquid port 1 is covered with the extracorporeal circulation module joint 100 according to the present invention in a close contact state.

  The liquid port 1 conforms to the ISO8637 standard having an open cylindrical portion communicating with the inside of the extracorporeal circulation module 15, and the extracorporeal circulation module joint 100 is connected to the liquid port 1.

  The inflow port and the outflow port constituted by the liquid port 1 have the same shape, and the extracorporeal circulation module joint 100 to be covered therewith is also the same. Therefore, in the following, the present invention will be described by taking an inflow port as an example of the liquid port 1 of the extracorporeal circulation module 15 and taking an extracorporeal circulation module joint 100 as an example.

  First, the extracorporeal circulation module joint 100 of the extracorporeal circulation module liquid port 1 will be described with reference to FIGS. In the following description, when the direction is described using the up and down directions, it is the up and down direction in the posture in which the extracorporeal circulation module 15 is installed with the liquid port 1 facing up.

  The extracorporeal circulation module 15 to which the present invention is applied is an extracorporeal circulation module used for extracorporeal circulation treatment of a bodily fluid represented by blood or plasma. Examples include artificial kidneys, hemofiltration dialysers, blood filters, plasma component separators, plasma separators, leukocyte removers, blood component adsorbers and the like as described above.

  When the extracorporeal circulation treatment of the bodily fluid is performed, the fluid port 1 is used for flowing a physiological solution for priming the extracorporeal circulation module 15 and collecting the bodily fluid, circulating the bodily fluid itself, or flowing the dialysate. At that time, the extracorporeal circulation module joint 100 connecting the liquid port 1 and the medical tube 6 is required to have high pressure-tightness and air-tightness due to inflow and outflow of fluid such as body fluid from the liquid port 1. Therefore, the extracorporeal circulation module joint 100 according to the present invention is preferably used.

  As shown in FIGS. 3 to 6, the liquid port 1 is a liquid port for an extracorporeal circulation module that conforms to the ISO8637 standard, and has a cylindrical wall 23, a tip of which has a small diameter portion 24, and a liquid An annular groove 25 is provided on the base end side of the port 1. The annular groove portion 25 is used to stabilize the connection when a part of the device enters when connecting to another device such as a Hansen coupler.

  In the extracorporeal circulation module joint 100 of the first and second embodiments shown in FIGS. 3 and 4, the coupler 90 that can be connected to the outer wall of the liquid port 1 can be in close contact with the small-diameter portion 24 and the cylindrical wall 23 of the liquid port 1. As described above, the split cylinder 2 formed of the cylinder 90 of the coupler 90 is split into two via the hinge portion 5 and is covered with the liquid port 1.

  In the following, embodiments of the extracorporeal circulation module joint and the medical adapter using the same according to the present invention will be described in detail by taking as an example a case where the split cylinder 2 is a split cylinder. The number of divisions of the body 2 is not limited to two. The coupler 90 according to the present invention has two or more cuts along the axial direction of the cylindrical body of the coupler 90, and the hinge part 5 formed at the end of the adjacent cut on the medical tube 6 side. 10, the distal end of the coupler 90 on the base end side of the extracorporeal circulation module liquid port 1 can be opened and closed in a direction away from the outer wall of the liquid port 1.

  The split cylinder 2 according to the present invention refers to a part of the cylindrical body of the openable / closable coupler 90 having the hinge portions 5 and 10. The number of divisions of the split cylinder 2 is not particularly limited as long as it is two or more, but from the viewpoint of adhesion between the coupler 90 and the liquid port 1, the number of divisions of the split cylinder 2 is not less than 2 and not more than 8. Preferably, more preferably.

  Further, the split cylinders 2 do not have to be all equal in size, but in order to maintain uniform adhesion between the coupler 90 and the extracorporeal circulation module liquid port 1, it is more preferable that they are all equal in size. .

In addition, in the extracorporeal circulation module joint 100 of the first and second reference examples shown in FIGS. 5 and 6, the coupler 90 that can be connected to the outer wall of the liquid port 1 is closer to the tip than the hinge portion 10 of the coupler 90. The small-diameter portion 24 of the liquid port 1 is fitted to the inner wall of a certain outer cylinder 11, and the split cylinder body 2 that is split into two via the hinge portion 10 of the coupler 90 is covered with the liquid port 1.

Further, in each embodiment shown in FIGS. 3 and 4 and each reference example shown in FIGS. 5 and 6, the annular protrusion 4 existing on the inner peripheral surface of the split cylinder 2 of the coupler 90 is provided on the liquid port 1. It enters into the annular groove 25 on the base end side and stabilizes the connection.

  In order to more firmly fit the coupler 90 and the liquid port 1, the lock nut 7 fitted into the coupler 90 is rotated to be formed on the outer peripheral surface of the coupler 90 including the split cylinder 2. A concave groove 8 formed on the inner peripheral surface of the lock nut 7 rotates along the ridge 3 so that the lock nut 7 is located on the base end side of the liquid port 1 (the left end in FIGS. 3 to 6). Part).

  As shown in FIGS. 3 (a), 4 (a), 5 (a) and 6 (a), the inner diameter of the lock nut 7 is the base end side of the extracorporeal circulation module liquid port 1 (FIG. 3). To the left end of FIG. 6).

Thus, as the locking nut 7 is rotated and pushed, the coupler 90 and the liquid port 1 are completely liquid-tightly fitted. The inner diameter of the lock nut 7 may be constant, but in order to make the liquid tightness between the coupler 90 and the liquid port 1 more complete, the inner diameter of the lock nut 7 has an inclined structure. Is preferred. When the inner diameter of the lock nut 7 has an inclined structure, the inclination angle θ ₁ is preferably 1 to 10 degrees, and the inclination angle θ ₁ is more preferably an angle of 1 to 5 degrees. Further, it is preferable to adopt an inclined structure in which the outer diameter of the coupler 90 gradually increases toward the base end side of the extracorporeal circulation module liquid port 1 (the left end in FIGS. 3 to 6). When the outer diameter of the coupler 90 has an inclined structure, the inclination angle θ ₂ is preferably the same as the inclination angle θ ₁ of the inner diameter of the lock nut 7.

When the O-ring 9 is fitted on the inner peripheral surface of the outer cylinder 11 of the coupler 90 as in the first and second reference examples shown in FIGS. 5 and 6, the small diameter portion of the liquid port 1 is formed on the inner wall of the outer cylinder 11. This is preferable because the liquid-tightness is increased when 24 is fitted.

  The material of the coupler 90 is not particularly limited, but it is desirable to have a certain degree of shape retention and flexibility. As the soft resin for that purpose, for example, polyolefins such as polyethylene and polypropylene, relatively hard resins such as polycarbonate, polystyrene, polyamide and polyacetal, and relatively soft materials such as vinyl chloride and rubber can be listed. Among them, materials such as vinyl chloride, rubber, polyethylene, and polypropylene are particularly preferable because of adhesion and ease of molding, and vinyl chloride is most preferable.

  In the first and second embodiments shown in FIGS. 3 and 4, the coupler 90 has a structure in which the coupler 90 is crowned in close contact with the cylindrical wall 23 of the liquid port 1, and is split into two via the hinge portion 5. 2, an annular protrusion 4 is formed on the inner peripheral wall of the split cylinder 2, and the peripheral wall 23 and the small diameter portion 24 of the liquid port 1 can be completely covered. Further, a ridge 3 is formed on the outer peripheral wall of the split cylinder 2.

  The two split cylinders 2 each have a top plate 12 and are coupled to each other via the hinge portion 5 and are hermetically coupled to the outer wall of the inner cylinder outer tube 14. The inner / outer tube 14 provided in the coupler 90 is connectable to the medical tube 6 and communicates with the opening of the liquid port 1. An inner cylinder / outer tube 14 connectable to the medical tube 6 is formed on the top plate 12 of the second embodiment shown in FIG. 4, and the inner cylinder / outer tube of the first embodiment shown in FIG. 3 is a medical tube. FIG.

The coupler 90 of the first and second reference examples shown in FIG. 5 and FIG. 6 has a structure in which it is crowned in close contact with the cylindrical wall 23 of the liquid port 1, and the split cylinder 2 that splits into two via the hinge portion 10. An annular projection 4 is formed on the inner peripheral wall of the split cylinder 2, an outer cylinder 11 is formed on the medical tube 6 side of the coupler 90, and the outer cylinder 11 is a liquid port 1 is fitted into the small diameter portion 24.

  The length of the hinge part 10 may be any length as long as the part on the extracorporeal circulation module 15 side of the split cylinder 2 can be easily opened, as shown in FIGS. 5 (b) and 6 (b). Thus, when assuming a virtual circle perpendicular to the axis of the coupler 90 having the hinge portion 10 on the circumference, the acute angle α formed by two straight lines connecting the center of the virtual circle and both ends of the hinge portion 10 is It is preferable that the angle is 1 to 90 degrees, and considering the ease of opening and closing of the two split cylinders 2 and the strength of the hinge 10 due to repeated opening and closing, the acute angle α is more preferably 10 to 30 degrees. .

The two split cylinders 2 are connected to the outer cylinder 11 to be crowned at the tip of the liquid port 1 via a hinge part 10, and the inner wall of the outer cylinder 11 is connected to the outer wall of the inner cylinder outer pipe 14. The plate 13 is airtightly coupled. In the second reference example shown in FIG. 6, an inner cylinder outer tube 14 that can be connected to the medical tube 6 is formed on the connecting plate 13, and in the first reference example shown in FIG. 5, the inner cylinder outer tube 14 is used for medical purposes. It is an example integrally formed with the tube 6.

  Although not shown, the split cylinder 2 may be connected to the connecting plate 13 that is airtightly connected to the outer wall of the inner cylinder outer tube 14 via the hinge portion 5. For example, the split cylinder 2 may be divided into three parts. In the case of the cylindrical body 2, a hinge portion 5 is provided on each side of the equilateral triangular connecting plate 13, and the split cylindrical body 2 configured in three parts is coupled to the connecting plate 13 via the hinge portion 5. In the four-divided split cylinder 2, the shape of the connecting plate 13 is square. In the five-split split cylinder 2, the connecting plate 13 is a regular pentagon. In the six-divided split cylinder 2, the shape of the connecting plate 13 is regular six. Similarly, the split cylindrical body 2 which is divided into multiple sides via hinges 5 on each side of various polygonal connecting plates 13 can be connected to the connecting plate 13.

The inner wall of the connecting plate 13 of the second reference example shown in FIG. 6 has an inner cylinder inner tube 20, which communicates with the inner cylinder outer tube 14 and is inside the inner cylinder wall 23 of the liquid port 1. It is inserted liquid-tight into the peripheral surface.

  With the above configuration, the circumferential wall 23 and the small diameter portion 24 of the liquid port 1 can be completely crowned by the coupler 90.

Projections 3 are formed on the outer peripheral surface of the split cylinder 2. In the coupler structures of the first and second reference examples shown in FIGS. 5 and 6, Although it is preferable to install the O-ring 9 on the inner peripheral surface, it may not be installed. In addition, in the coupler structures of the first and second reference examples shown in FIGS. 5 and 6, a coupler 90 coupling plate that is fitted to the inner peripheral surface of the small-diameter portion 24 of the liquid port 1 in order to further improve the fitting property. Although it is preferable to install the inner cylinder inner tube 20 on the inner wall of 13, it is not necessary to install it.

  When the concave groove 8 formed on the inner peripheral surface of the lock nut 7 is fitted into the coupler 90 and rotated, the ridge 3 formed on the outer peripheral surface of the coupler 90 enters and tightens the two split cylinders 2. The coupler 90 and the liquid port 1 can be hermetically coupled, and the number corresponding to the ridges 3 existing on the outer peripheral surface of the split cylinder 2 of the coupler 90 or one or two less than that. The concave groove 8 is formed in a direction along the ridge 3 on the outer peripheral surface of the split cylinder 2 of the coupler 90.

Further, the inner diameter of the lock nut 7 has an inclined structure that gradually increases toward the base end side of the liquid port 1 (the left side in FIGS. 5A and 6A). The inclination angle θ ₁ is preferably in the range of 1 to 10 degrees, and more preferably, the inclination angle θ ₁ is in the range of 1 to 5 degrees.

Further, the outer diameter of the coupler 90 has an inclined structure that gradually increases toward the base end side of the liquid port 1 (the left side in FIGS. 5A and 6A), and the inclination angle θ ₂ is also set. It is preferable to adopt an inclination structure similar to the inclination angle θ ₁ of the inner diameter of the lock nut 7. The inner diameter of the lock nut 7 may be constant, but in order to make the liquid tightness of the coupler 90 and the liquid port 1 more complete, the inner diameter of the lock nut 7 is inclined. Is more preferable.

  When the lock nut 7 is rotated in the direction of the arrow in FIGS. 3 (a), 4 (a), 5 (a), and 6 (a), the split cylinder 2 of the coupler 90 is in close contact with the liquid port 1. Thus, as the rotation proceeds, the adhesiveness between the split cylinder 2 and the liquid port 1 is further increased.

  When the coupler 90 is joined, the coupler 90 is covered from above the liquid port 1, and the top plate 12 or the connecting plate 13 connected to the medical tube 6 of the coupler 90 is applied to the tip of the liquid port 1. . Thereafter, the two split cylinders 2 are crowned from both sides of the liquid port 1 via the hinge part 5 or the hinge part 10. Thereafter, the lock nut 7 is rotated along the ridges 3 on the outer peripheral surface of the split cylinder 2. As it rotates, the inner peripheral wall of the split cylinder 2 is tightened against the cylindrical wall 23 and the annular groove 25 of the liquid port 1 to complete the connection in a close contact state.

  When the coupler 90 is separated, the outer peripheral surface of the lock nut 7 is grasped, and in the direction opposite to the arrows in FIGS. 3 (a), 4 (a), 5 (a) and 6 (a). If the split cylinder 2 is opened on both sides via the hinge 5 or the hinge 10 and then the coupler 90 is pulled up in the axial direction of the liquid port 1, the extracorporeal circulation module joint 100 and the liquid port 1 The separation work ends.

  Therefore, all the operations for joining and separating the extracorporeal circulation module joint 100 can be performed in a state where the split cylinder 2 portion of the coupler 90 is pressed with a finger, and there is no possibility of touching the liquid port 1. Further, since the coupler 90 has a split cylinder structure that can be divided into two, the connection work is easy.

  In addition, the annular protrusion 4 formed on the inner peripheral surface of the split cylinder 2 of the coupler 90 is in close contact with the annular groove 25 of the liquid port 1 and is maintained in that state. There is no free movement in the axial direction of the liquid port 1. For this reason, even if the internal pressure in the extracorporeal circulation module 15 rises or becomes negative, the coupler 90 is not inadvertently disconnected or the contact state is not destroyed.

  The inner and outer tubes 14 of the second embodiment shown in FIG. 4 are inserted into the medical tube 6 in close contact with each other, and the hollow portion of the top plate 12 and the hollow portion of the inner and outer tubes 14 communicate with each other. 90 completes the liquid-tight connection between the liquid port 1 and the medical tube 6.

  The fitting method in the close contact state between the medical tube 6 and the inner cylinder outer tube 14 of the joint 100 for the extracorporeal circulation module according to the present invention is fitting using the flexibility of the medical tube 6, bonding with an adhesive, or the like. Can be carried out by a known method. Moreover, if the joint 100 for extracorporeal circulation modules which concerns on this invention is previously joined or integrally molded to the medical tube 6, it can provide as the medical tube (medical circuit) 6 provided with the characteristic of this invention. Is possible.

  2 and 7 are diagrams for explaining connection of a medical adapter having various extracorporeal circulation module liquid port structures at one end and the extracorporeal circulation module joint 100 according to the present invention at the other end.

  FIG. 7A shows an extracorporeal circulation module liquid in which two or more spaced ridges 16b are formed on the same circumference in a direction orthogonal to the axis of the outer peripheral surface of the cylindrical portion of the extracorporeal circulation module liquid port 16. A medical adapter having a port structure at one end of a medical tube 6 and having the joint 100 for an extracorporeal circulation module of the present invention at the other end is shown. In the figure, 16a is an annular groove, and 16c is a medical tube connecting inner cylinder.

  FIG. 7B shows an extracorporeal circulation module liquid port structure in which one end of a medical tube 6 has a protrusion 17 c formed in a direction oblique to the axis of the outer peripheral surface of the cylindrical portion of the extracorporeal circulation module liquid port 17. The medical adapter which has the joint 100 for extracorporeal circulation modules of this invention in the other end is shown. In the figure, 17a is an annular groove portion, 17b is a screw portion, and 17d is an inner tube for connecting a medical tube.

  Further, FIG. 7C has an extracorporeal circulation module liquid port structure in which a male thread 18b is formed on the outer peripheral surface of the cylindrical portion of the extracorporeal circulation module liquid port 18, and the other end of the extracorporeal circulation module of the present invention. The medical adapter which has the joint 100 for medical treatment is shown. In the figure, 18a is an annular groove and 18c is a medical tube connecting inner cylinder.

  One end is a joint 100 for an extracorporeal circulation module of the present invention, and the other end is the above-described various liquid ports 16, 17, 18, 19 to provide a device or circuit dedicated to a commercially available extracorporeal circulation module 15. However, by using the medical adapter of the present invention, a wide variety of extracorporeal circulation modules 15 can be used, which is extremely advantageous for the medical field.

  In FIG. 7A, an inner cylinder 16c that facilitates connection between the medical tube 6 having a liquid port structure may be provided for connection between the liquid port 16 of the medical adapter and the medical tube 6. The liquid port 16 and the medical tube 6 may be integrally formed. The same applies to FIGS. 7B and 7C.

  EXAMPLES Hereinafter, although this invention is demonstrated further in detail according to an Example, this invention is not limited to these.

[ Reference Example 1]
The polysulfone dialyzer APS-11S (manufactured by Asahi Kasei Medical Co., Ltd.) is used as the extracorporeal circulation module 15 having the liquid port 1 for dialysate, and the extracorporeal circulation described in FIGS. 5 and 6 as the joint 100 for the extracorporeal circulation module. A module joint 100 was used. A pipe (master flex) is formed by connecting a silicon tube 6 having an inner diameter of 8.0 mm to an inner cylinder / outer pipe (outer diameter 9.0 mm) 14 of the joint 100 for the extracorporeal circulation module to two liquid ports 1 for dialysate. Saline was circulated for 4 hours at a flow rate of 500 ml / min using a digital pump, model 7524-00, manufactured by Cole-Parmer Instrument Co., USA. As a result, regardless of which extracorporeal circulation module joint 100 of FIGS. 5 and 6 is used, the joint portion between the extracorporeal circulation module joint 100 and the dialysate liquid port 1 of the dialyzer and the extracorporeal circulation module joint 100 There was no leakage of physiological saline from the connecting portion with the silicon tube 6. That is, even at high flow rate and high pressure for dialysate circulation, the adhesion of the extracorporeal circulation module joint 100 of the present invention and the dialysate liquid port 1 was completely maintained.

[ Reference Example 2]
The polysulfone dialyzer APS-08S (manufactured by Asahi Kasei Medical Co., Ltd.) is used as the extracorporeal circulation module 15 having the liquid port 1 for dialysate, and the extracorporeal circulation described in FIGS. 5 and 6 as the joint 100 for the extracorporeal circulation module. A module joint 100 was used. A silicone tube 6 having an inner diameter of 8.0 mm connected to an inner cylinder outer pipe (outer diameter 9.0 mm) 14 of the joint 100 for the extracorporeal circulation module is joined to the liquid port 1 for one dialysate and the other dialyzed liquid. A manometer (model PG-200-102GH-P, manufactured by Copal Electronics, Japan) was connected to the liquid port 1 for liquid measurement. From the blood port side of the dialyzer, bovine plasma is circulated at a flow rate of 100 ml / min for 30 hours with a blood pump (model ABP-102, manufactured by Asahi Kasei Medical Corporation, Japan), and simultaneously from the liquid port 1 side for dialysate The solution was suction filtered with a blood pump (model ABP-102, manufactured by Asahi Kasei Medical Corporation, Japan) at a flow rate of 15 ml / min. As a result, the pressure of the liquid port 1 for dialysate after 30-hour circulation test of bovine plasma was −30 mmHg. 5 and 6, the joint part between the extracorporeal circulation module joint 100 and the dialyzer fluid port 1 during the 30-hour circulation test of bovine plasma. There was no leakage of plasma from the connection part between the extracorporeal circulation module joint 100 and the silicon tube 6. That is, even in the negative pressure state during filtration, the adhesion of the joint between the extracorporeal circulation module joint 100 and the liquid port 1 for dialysate was completely maintained.

  The extracorporeal circulation module joint 100 according to the present invention is useful as an extracorporeal circulation module joint 100 for liquid-tightly connecting the liquid port 1 of the extracorporeal circulation module 15 and the medical tube 6 and is represented by blood and plasma. Extracorporeal circulation module 15 used for extracorporeal circulation treatment of body fluids used, for example, artificial kidney, hemofiltration dialyzer, hemofilter, plasma component separator, plasma separator, leukocyte remover, blood component adsorber, etc. When performing extracorporeal circulation treatment of body fluid, it is particularly useful for securely connecting the liquid port 1 of the extracorporeal circulation module 15 and the medical tube (circuit) 6 in a fluid-tight manner. Moreover, since the medical adapter of the present invention can be fitted into various devices, it is convenient in the medical field.

It is a side view explaining the state which connected the joint for extracorporeal circulation modules which concerns on this invention to the liquid port for extracorporeal circulation modules. It is an isometric view explanatory drawing explaining embodiment using the coupling for extracorporeal circulation modules which concerns on this invention as a medical adapter. (A) is a sectional side view showing the configuration of the first embodiment of the joint for extracorporeal circulation module and the liquid port for extracorporeal circulation module according to the present invention, and (b) is a perspective view of the coupler of the first embodiment. (A) is sectional side view which shows 2nd Embodiment of the coupling for extracorporeal circulation modules which concerns on this invention, and the structure of the liquid port for extracorporeal circulation modules, (b) is a perspective view of the coupler of 2nd Embodiment. (A) is a cross-sectional side view illustrating a first reference examples and configuration of the fluid ports for extracorporeal circulation module fitting for a body out of circulation module, (b) is a perspective view of the coupler of the first embodiment. (A) is a cross-sectional side view showing a second reference examples and configuration of the fluid ports for extracorporeal circulation module fitting for a body out of circulation module, (b) is a perspective view of the coupler of the second reference example. (A)-(c) is the medical adapter shown in FIG. 2, The partial cross-sectional side view which showed the various embodiment of the liquid port for other extracorporeal circulation modules attached to the circuit side front-end | tip of this medical adapter. is there.

DESCRIPTION OF SYMBOLS 1 ... Liquid port for extracorporeal circulation modules 2 ... Split cylinder 3 ... Convex strip 4 ... Annular projection 5 ... Hinge part 6 ... Medical tube 7 ... Lock nut 8 ... Groove 9 ... O-ring
10 ... Hinge part
11 ... outer cylinder
12 ... top plate
13 ... Connecting plate
14 ... Inner cylinder outer tube
15 ... extracorporeal circulation module
16, 17, 18, 19 ... liquid port for extracorporeal circulation module
16a, 17a, 18a ... annular groove
16b ... ridge
16c ... Inner tube for medical tube connection
17b ... Screw part
17c ... ridge
17d ... Medical tube connection inner cylinder
18b ... Male thread
18c ... Inner cylinder for medical tube connection
20 ... Inner cylinder inner pipe
23 ... Cylinder wall
24 ... Small diameter part
25 ... annular groove
30 ... Inlet
31 ... Outlet
90 ... coupler
100 ... Fitting for extracorporeal circulation module

Claims (8)

A joint for an extracorporeal circulation module connected to a liquid port for an extracorporeal circulation module conforming to ISO8637 standard having an open cylindrical portion communicating with the inside of the extracorporeal circulation module
The joint for the extracorporeal circulation module has a coupler connectable to the outer wall of the liquid port for the extracorporeal circulation module, and a lock nut fitted into the coupler. The coupler has a top plate coupled to each other via a hinge portion. A split cylinder having an end, and an inner cylinder / outer pipe that can be connected to a medical tube and communicated with an opening of the liquid port for the extracorporeal circulation module, An annular protrusion is formed on the surface so as to enter an annular groove on the base end side of the extracorporeal circulation module liquid port when connected to the extracorporeal circulation module liquid port. Is formed with a concave groove on the inner peripheral surface of the locking nut so that the convex strip formed on the outer peripheral surface of the coupler enters when the coupler is fitted and rotated. Extracorporeal circulation mod Lumpur fittings. The joint for an extracorporeal circulation module according to claim 1, wherein the inner and outer tubes are formed integrally with the medical tube. The lock nut has an inclined structure in which the inner diameter of the extracorporeal circulation module gradually increases toward the base end side of the extracorporeal circulation module, and the outer diameter of the coupler is the base end side of the extracorporeal circulation module liquid port The joint for an extracorporeal circulation module according to claim 1 or 2 , wherein the joint has an inclined structure that gradually widens toward the outside. The joint for extracorporeal circulation module according to any one of claims 1 to 3 , wherein the coupler is made of a soft resin. The joint for an extracorporeal circulation module according to any one of claims 1 to 4 , wherein the split cylinder is a cylinder divided into two. A liquid port structure for an extracorporeal circulation module in which two or more spaced ridges are formed on the same circumference in a direction perpendicular to the axis of the outer peripheral surface of the cylindrical portion of the liquid port for the extracorporeal circulation module is formed at one end of the medical tube. A medical adapter comprising the joint for an extracorporeal circulation module according to any one of claims 1 to 5 at the other end. A liquid port structure for an extracorporeal circulation module in which a ridge is formed in a direction oblique to the axis of the outer peripheral surface of the cylindrical portion of the liquid port for the extracorporeal circulation module is provided at one end of the medical tube, and the other end is claimed in claim 1. A medical adapter comprising the joint for extracorporeal circulation module according to any one of 5 . It has the liquid port structure for extracorporeal circulation modules by which the external thread is formed in the cylindrical part outer peripheral surface of the liquid port for extracorporeal circulation modules, and the other end is for the extracorporeal circulation modules in any one of Claims 1-5 . A medical adapter comprising a joint.

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