JP4958291B2 - Sensor chip measuring device - Google Patents

Description

  The present invention relates to a sensor chip measurement device used for blood glucose level measurement and the like. More specifically, the present invention relates to a sensor chip measuring apparatus that uses a needle integrated sensor chip in which a puncture needle and a sensor chip main body are integrated, and includes an airtight decompression chamber in order to improve the measurement success rate.

  The biosensor chip is a sensor chip that introduces a trace sample such as blood into the chip and outputs information obtained by a biochemical reaction on the trace sample generated in the chip to the outside of the chip. For example, this biosensor chip is incorporated in a blood glucose level sensor that measures the amount of glucose (blood glucose level) in blood, and is used for home health diagnosis (self-care) for self-management and prevention of diabetes.

  A biosensor whose blood is to be measured, such as a blood glucose level sensor, has a puncture device for puncturing an object to be examined such as a finger with a puncture needle so as to flow out the blood, and a biosensor chip that has been incorporated into the biosensor. It consists of a measuring device that measures blood by introducing blood into the chip. In the biosensor, not only the biosensor chip but also the replacement of the puncture needle must be performed for each measurement from the viewpoint of hygiene. Therefore, when the puncture device and the measurement device are separate devices, the puncture needle and the biosensor chip must be exchanged separately, and there is a problem that the operation is complicated.

In order to solve such a problem, a sensor in which a puncture device and a measurement device incorporating a biosensor chip are integrated is disclosed in International Publication No. WO2002-056769 (Patent Document 1) and the like. The sensor described in Patent Document 1 describes a “lancet (puncture device) for collecting body fluid (blood, etc.) by piercing (puncturing) a subject's skin, and analyzing the collected body fluid. A lancet-integrated sensor configured integrally with a sensor body (measuring device) (Claim 1).
International Publication WO2002-056769

  According to this lancet-integrated sensor, the sensor (measuring device) and the lancet (puncture device) can be managed together without being managed separately, and handling becomes easy and the operability is improved. 1 (page 11 lines 44 to 47). However, even in this sensor, after the fingertip has been punctured, it is necessary to perform the operation of spotting blood on the sensor (page 21, lines 10 to 12), and there is a problem in the operability.

  That is, the amount of blood that has flowed out by puncture is very small, and it is difficult to spot it on the sensor, and it is particularly difficult for people with reduced vision who are often diabetics. As a result, there is a problem that the introduction of the sample into the biosensor chip becomes insufficient and the measurement success rate decreases.

  According to the present invention, the puncture needle and the biosensor chip can be exchanged together, and after the puncture, the trace amount sample that has flowed out without requiring a spotting operation to the sensor can be introduced into the chip. It is an object of the present invention to provide a sensor chip measuring apparatus having excellent operability and a high measurement success rate.

  As a result of intensive studies, the inventor has used a needle-integrated sensor chip having a puncture needle and a sample introduction hole at the tip of the sensor chip body, and provided an airtight decompression chamber. The present inventors have found that a high measurement success rate can be obtained by a sensor chip measuring device having a suction structure, thereby completing the present invention.

That is, the present invention
A sensor chip measuring device using a needle integrated sensor chip,
Mounting portion of the needle integrated sensor chip,
An airtight decompression chamber for housing the mounting portion;
Decompression means for decompressing the hermetic decompression chamber;
A lid of the hermetic decompression chamber that is openably and closably attached to the hermetic decompression chamber;
A test object contact port provided in the hermetic decompression chamber and opened outside the sensor chip measuring device;
A puncturing means for puncturing the object to be inspected by the needle-integrated sensor chip, and a data processing section for processing an output from the needle-integrated sensor chip;
A sensor chip measuring device, comprising: (Claim 1).

  The sensor chip measuring apparatus of the present invention is an integrated type having both a function as a puncturing apparatus that punctures an object to be inspected and a function as a measuring apparatus that performs measurement by introducing blood that has flowed out through puncturing into the sensor chip. It is a sensor chip measuring device. In addition, since the needle-integrated sensor chip is used, in the measurement using this apparatus, the puncture needle and the biosensor chip can be exchanged together.

  A needle-integrated sensor chip (hereinafter sometimes simply referred to as a sensor chip) has a puncture needle and a sample introduction hole at one end (tip) of the sensor chip body. The sensor chip body has a reaction part in which a sample is introduced and a reaction for measurement is performed, and at least a pair of electrodes exposed in the reaction part. For example, this needle-integrated sensor chip holds the sensor chip body in the casing, and is provided with a puncture needle and a sample introduction hole at one end of the casing, and connects the sample introduction hole and the reaction part. An electrode can be exposed at the other end of the main body. The sample introduction hole is a thin hole that allows introduction of a sample by capillary action, and the puncture needle is usually accommodated in the sample introduction hole.

  The sensor chip is mounted in a sensor chip measuring device and used for measurement. The sensor chip measuring device of the present invention is characterized by having an airtight decompression chamber that houses a sensor chip mounting portion. The hermetic decompression chamber is provided with an inspection object contact opening that opens outside the sensor chip measuring device. At the time of measurement, an object to be inspected such as a fingertip is brought into contact with the inspected object contact opening to close the opening, and the puncture needle at the tip of the sensor chip is inspected from the inspected object contact opening by the puncturing means described later. The body is rapidly moved in the body direction, and the object to be examined is punctured.

  A lid is detachably attached to the hermetic decompression chamber, and a sensor chip used for measurement is inserted into the hermetic decompression chamber by opening the lid and attached to the attachment part. At the time of measurement, the lid is closed and the contact hole of the inspection object is closed by the inspection object, so that the airtight decompression chamber becomes airtight. The lid may have the same size and area as the measuring device, or may be a small local one as long as it has the minimum size necessary for insertion of the sensor chip. When the lid is large, the sensor chip can be easily inserted. On the other hand, a small lid is preferable for maintaining airtightness in the airtight decompression chamber. In addition, the hinge part of the lid is provided in a portion other than the hermetic decompression chamber, but the hermetic decompression chamber is sealed by closing the lid. This is also included.

  In addition, the sensor chip measuring apparatus of the present invention has means (pressure reducing means) for reducing the pressure in the hermetic decompression chamber, and during the measurement, the pressure reducing means decompresses the airtight decompression chamber. As a result, the portion of the body to be inspected that is in contact with the body to be inspected is also decompressed, so-called congestion occurs, and blood or the like easily flows out by puncture. In addition, since the object to be inspected is sucked inwardly of the contact opening, the contact becomes more reliable, and a deviation during measurement is less likely to occur. Furthermore, the spilled blood or the like is easily introduced into the reaction part in the sensor chip provided in the hermetic decompression chamber, and the sample is sufficiently introduced into the reaction part, thereby improving the measurement success rate.

  The sensor chip measuring apparatus of the present invention has puncturing means for rapidly moving the sensor chip in the direction of the contact hole of the test object and puncturing the test object with the puncture needle. Examples of the puncturing means include a spring and a means having a compression means thereof. At this time, the puncturing is performed by moving the needle-integrated sensor chip toward the inspected object contact port by releasing the compressed state of the spring. (Claim 2). Specifically, it has a spring for urging the sensor chip in the puncture direction and a compression means for compressing the spring. Before the puncture, the compressed state of the spring compressed by the compression means is locked, and the lock is locked during puncture. The compressed state of the spring is released by the release, and the sensor chip is rapidly moved in the direction of the test object contact port by the biasing force of the spring.

  After puncturing, the puncture needle is withdrawn from the object to be inspected. This extraction is provided at the tip of the sensor chip by an elastic body such as a spring or an air damper, or at the tip of the sensor chip. This can be done by the restoring force of the elastic body that has been elastically deformed.

  As a preferred embodiment of the sensor chip measuring apparatus according to the present invention, the pressure reducing means of the hermetic decompression chamber and / or the compression means of the spring is further operated by opening and closing the lid of the hermetic decompression chamber. Provide a measuring device.

That is, in the sensor chip measuring device, the spring compression means is operated by opening and closing a lid of an airtight decompression chamber (Claim 3), and the pressure reducing means A sensor chip measuring device (Claim 4) comprising a decompression pump that operates by opening and closing a lid of an airtight decompression chamber.

  In the aspect of claim 3, the puncture spring is compressed by opening and closing the lid of the hermetic decompression chamber when the sensor chip is inserted into the hermetic decompression chamber. The compressed state of the spring is locked by the locking means. According to the fourth aspect of the present invention, the decompression pump is operated by opening and closing the lid of the hermetic decompression chamber. For example, when the lid of the hermetic decompression chamber is opened and closed, the piston in the decompression pump moves to decompress the interior of the decompression pump. The operation of the decompression pump may include a method of compressing or extending a spring connected to a piston in the decompression pump by opening and closing the lid. The spring is locked in the compressed or extended state, but the piston is actuated and depressurized by the biasing force of the spring generated by releasing the lock.

  According to the aspect of claim 3 or claim 4, when the sensor chip is inserted into the hermetic decompression chamber, the puncture spring is automatically compressed and / or the decompression pump is operated. The operation of the device becomes easier.

  On the other hand, the compression of the puncture spring and / or the operation of the decompression pump can be performed by an operation means that protrudes outside the measuring device, such as an operation button or a cocking lever, instead of opening and closing the lid of the hermetic decompression chamber. The invention according to claim 5 further includes an operating means that protrudes outside the sensor chip measuring device, and releasing the compressed state of the spring is performed by operating the operating means. It is a sensor chip measuring apparatus as described in above. The invention described in claim 6 further includes an operating means that protrudes outside the sensor chip measuring device, and the pressure reduction in the hermetic decompression chamber is performed by operating the operating means. A sensor chip measuring apparatus according to claim 1, claim 2, or claim 5.

  Here, examples of the operation means that protrudes outside the sensor chip measuring apparatus include an operation button and a cocking lever. One operation button or cocking lever or the like may act both for releasing the compression state of the spring and for reducing the pressure in the hermetic decompression chamber. Furthermore, you may have the effect | action of cancellation | release of decompression of an airtight decompression chamber. If one operation means has multiple actions such as release of spring compression, decompression of hermetic decompression chamber, release of decompression, etc., the number of buttons and levers necessary for operation is reduced and operability is improved. On the other hand, there is a possibility of causing an erroneous operation.

  The mounting part of the needle-integrated sensor chip may be a part for mounting a plurality of sensor chips at the same time. For example, a magazine including a plurality of sensor chips may be mounted on the mounting portion.

  When one sensor chip is mounted, the lid of the hermetic decompression chamber is opened and closed in order to insert the sensor chip for each measurement, but the sensor chip is formed into a magazine and a plurality of sensor chips are mounted on the mounting portion. When is installed, the lid of the hermetic decompression chamber is not opened / closed for each measurement. Therefore, it is necessary to provide an operation button, a cocking lever, or the like that protrudes outside the measuring apparatus as an operation means for the decompression pump or a compression means for the puncture spring.

  The sensor chip measuring apparatus of the present invention further includes a data processing unit that processes the output from the sensor chip. Furthermore, although the data display unit for displaying the data output from the data processing unit is provided, the data display unit may be provided outside the sensor chip measuring device, and the data output terminal may be provided in the measuring device. An example of the data display unit is a liquid crystal display device.

  The invention according to claim 7 is the sensor chip measuring apparatus, wherein the data processing unit is provided in a lid of the hermetic decompression chamber. It is preferable to provide the data processing unit in the lid of the hermetic decompression chamber because the sensor chip measuring device can be made smaller. Furthermore, providing the data display part on the surface of the lid of the hermetic decompression chamber is more preferable because of the effect that the display is easy to see.

  The sensor chip measuring device of the present invention can improve the measurement success rate when using a needle integrated sensor chip.

  Next, the embodiment of the present invention will be described more specifically with reference to the drawings. However, the scope of the present invention is not limited to this embodiment. That is, it should be considered that the embodiments disclosed herein are illustrative and non-restrictive in every respect. The scope of the present invention is defined by the terms of the claims, and includes all modifications within the scope and meaning equivalent to the terms of the claims.

  FIG. 1 is an external view of a sensor chip measuring apparatus according to the present invention. In the figure, reference numeral 1 denotes an apparatus main body, and reference numeral 2 denotes a lid that covers the entire surface of the apparatus main body 1. The lid 2 is configured to rotate about a hinge 4 and to be opened and closed.

  On the surface of the lid 2, a display unit 3 for displaying the measured value is provided. An operation button 8 is provided on the upper part of the apparatus main body 1.

  FIG. 2 is a view showing a state in which the lid 2 of the sensor chip measuring apparatus shown in FIG. 1 is opened, that is, a view showing the inside of the apparatus. In the figure, 11 is an airtight decompression chamber. In the figure, reference numeral 6 denotes a connector which is a mounting portion of the needle integrated sensor chip, and is provided in the hermetic decompression chamber 11.

  In the figure, reference numeral 7 denotes a needle-integrated sensor chip, and one end of the needle-integrated sensor chip 7 is fitted into a notch (not shown in FIG. 2) of the connector 6. A puncture means 9 made of a puncture spring is provided on the upper portion of the connector 6, and the spring is compressed and locked by a locking means 91. The locking means 91 is interlocked with the operation button 8, and the lock is released by operating the operation button 8. The hermetic decompression chamber 11 has a test object contact opening 12 that opens to the outside of the apparatus main body 1.

  Reference numeral 15 denotes a decompression pump for decompressing the hermetic decompression chamber 11, and reference numeral 17 denotes an opening / closing part provided on the wall surface of the hermetic decompression chamber 11 and connected to the decompression pump 15.

  FIG. 3 is a cross-sectional view showing the decompression pump 15 and its periphery. As shown in FIG. 3, the decompression pump 15 includes a cylinder 52, a piston 53, an urging plate 56 connected to the piston 53 by a rod, and an intake pipe 57 that connects the opening / closing portion 17 and the decompression pump 15. The urging plate 56 is connected to the lid 2 by a rod or the like, and the urging plate 56 is pressed in the direction of A in the figure by opening and closing the lid 2. As a result, the piston 53 connected to the urging plate 56 moves in the direction of arrow B in the figure, and moves from the position indicated by the dotted line to the position indicated by the solid line. At this time, since the opening / closing part 17 is closed, the pressure in the vacuum pump 15 is reduced. When the urging plate 56 moves a predetermined distance, the urging plate 56 is locked by the locking means 58, so that the decompression pump 15 is kept decompressed until the opening / closing part 17 is opened.

  FIG. 4 is a cross-sectional view showing a vacuum pump having a form different from that of the vacuum pump 15 and its periphery. As shown in FIG. 4, the decompression pump includes a cylinder 52, a piston 53, an urging plate 56, and an intake pipe 57. The intake pipe 57 connects the decompression pump and the hermetic decompression chamber 11 and opens at an opening 51 on the side wall of the hermetic decompression chamber 11. The piston 53 and the urging plate 56 are connected by a rod 55, and an urging spring 54 is provided between one end of the cylinder 52 and the urging plate 56.

  FIG. 4A shows a state before the urging plate 56 is pressed. At this time, the urging spring 54 has a substantially natural length and almost no urging force is generated. In this decompression pump, the urging plate 56 is pressed in the direction of C in the figure by opening and closing the lid 2 or the like. Due to the pressing, the urging plate 56, the piston 53, and the like move in the direction D in the figure, and the state shown in FIG. At this time, the urging spring 54 is compressed and an urging force is generated. However, since the urging plate 56 is locked by the locking means 58, this state is maintained until the lock is released.

  The mechanism for generating the pressing force a and c by opening and closing the lid 2 is not particularly limited. For example, a method of connecting the lid 2 and the urging plate 56 with a rope, a rod, or the like can be given.

  FIG. 5 is a cross-sectional view of the connector 6, the needle integrated sensor chip 7, and the periphery of the inspected object contact port 12 cut in a direction perpendicular to the sensor chip body. In the figure, 61 is an electrode of the connector 6, and 62 is a sensor chip clamping portion. In the figure, reference numeral 71 denotes a sensor chip body, and the sensor chip body 71 is provided with the electrode 16 and the reaction unit 14. When the sensor chip is mounted, one end of the sensor chip body 71 is clamped by the sensor chip clamping unit 62, and at this time, the electrode 16 and the electrode 61 are electrically connected.

  As shown in FIG. 5, the sensor chip main body 71 is held in a casing 73. A puncture needle fixing portion 72 is further held in the casing 73, and the puncture needle 19 fixed to the distal end of the puncture needle fixing portion 72 and the reaction portion 14 of the sensor chip body 71 are held in close contact with each other. Yes.

  An elastic body 74 having a sample introduction hole 75 is provided at the tip of the casing 73, the tip of the puncture needle 19 is accommodated in the sample introduction hole 75, and the sample introduction hole 75 is connected to the reaction unit 14. It is connected with.

  In the figure, reference numeral 20 denotes a positioning ring, which is provided outside the hermetic decompression chamber 11 so as to surround the inspected object contact port 12. The positioning ring 20 is provided so that an object to be inspected, such as a finger, can be stably brought into contact with the object to be inspected contact hole 12. During measurement, the finger or the like directly contacts the positioning ring 20. Touched. In this example, a tip guide portion 21 for smooth movement of the needle-integrated sensor chip 7 is provided in the inspected object contact port 12.

  FIG. 6A is a partially cutaway sectional view of the periphery of the connector 6, the needle integrated sensor chip 7, the puncture means 9 (puncture spring), and the inspected object contact port 12. That is, the connector 6 and the puncture means 9 (and the locking means 91 and the locking lever 92) are external views, and the other parts are cross-sectional views cut in a direction parallel to the sensor chip body 71. The cross-sectional view represents a cross section of the AA portion of FIG.

  As is clear from FIG. 6A, the electrode 16 of the sensor chip body 71 is composed of a pair of electrodes (counter electrode, working electrode), and the tip of each electrode is exposed in the reaction unit 14. On one electrode, a drug 18 for causing a reaction is applied. The sample introduction hole 75 and the reaction part 14 are connected, and the sample introduced into the sample introduction hole 75 is introduced into the reaction part 14.

  The electrical signal generated by the reaction in the reaction unit 14 is output to the outside of the sensor chip by the electrode 16 and further output to the data processing unit by the electrode 61 that is in conduction therewith. The electrode 16 also has a function of applying a voltage from the outside to the reaction unit 14 as necessary. As shown in FIG. 6A, in this example, a locking means 91 and a locking lever 92 for locking the position of the connector 6 are further provided.

  Although not shown, a data processing unit is provided in the lid 2. The data processing unit is electrically connected to the electrode 61 (that is, the electrode 16) and the display unit 3. The sensor chip measuring apparatus of this example further includes a battery, which is a power source for operating the data processing unit and the display unit 3, in the apparatus main body 1, but these are not shown. Further, the power source and the display unit 3 may be provided outside the sensor chip measuring apparatus.

  Next, a procedure for measuring a blood glucose level by the sensor chip measuring apparatus described above will be described with reference to FIGS.

  First, the lid 2 is opened as shown in FIG. 2 in order to attach the needle-integrated sensor chip 7 to the hermetic decompression chamber 11. At this time, the operation of opening the lid 2 causes the connector 6 to be pressed in the direction of arrow G in FIG. 6A and to move in the direction of G (detailed explanation of the mechanism is omitted). By this movement, the puncture means 9 (puncture spring) is compressed and an urging force is generated, but the connector 6 is locked by the locking means 91, and this state is maintained until the lock is released.

  Next, the needle-integrated sensor chip 7 is attached to the connector 6 as shown in FIG. 2 (from the direction of the arrow in FIG. 2). As described above, this attachment is performed by sandwiching one end of the sensor chip body 71 between the sensor chip sandwiching portion 62, and as a result, the electrode 16 of the sensor chip body 71 and the electrode 61 of the connector 6 are electrically connected.

  When the sensor chip used in the previous measurement remains attached to the connector 6, the used sensor chip is removed before the attachment. The removal of the used sensor chip may be performed by a method of pulling out the sensor chip in the direction opposite to the direction of the arrow in FIG. 2, or may be performed by a method of pulling out from the inspected object contact port 12, and in this case, the lid 2 Used sensor chip can be removed without opening

  Thereafter, the lid 2 is closed. At this time, the piston 53 moves as shown in FIG. 3 (because the opening / closing part 17 is closed), and the pressure in the vacuum pump 15 is reduced. When the decompression pump shown in FIG. 4 is used in place of the decompression pump 15, the piston 53 is moved by closing the lid 2, and the state shown in FIG.

  Next, an object to be inspected, such as a fingertip, is brought into contact with the positioning ring 20. Since the lid 2 is already closed, the hermetic decompression chamber 11 is airtight by the lid 2 and the fingertip.

  After the hermetic decompression chamber 11 is airtight, the opening / closing part 17 is opened. Then, since the pressure in the vacuum pump 15 is reduced, the air in the hermetic decompression chamber 11 is sucked into the decompression pump 15 and the pressure in the hermetic decompression chamber 11 is reduced. When the decompression pump of FIG. 4 is used instead of the decompression pump 15, the lock by the locking means 58 is released after the hermetic decompression chamber 11 is brought into an airtight state. Then, the urging plate 56 is pressed by the urging force (restoring force) of the urging spring 54 and the piston 53 is moved, and the state shown in FIG. 4A is obtained, and the pressure reducing pump is depressurized. Since the decompression chamber 11 is connected, the inside of the hermetic decompression chamber 11 is also decompressed.

  In this manner, since the inside of the hermetic decompression chamber 11 is depressurized, a portion such as a fingertip that is in contact with the inspection object contact port 12 (positioning ring 20) is sucked, and so-called congestion occurs. This congestion facilitates blood flow during puncture and facilitates obtaining an amount of sample necessary for accurate measurement.

  Next, puncture is performed. By pushing the locking lever 92 in the direction of arrow E in FIG. 6A, the locking means 91 moves in the direction of the arrow, and the connector 6 is unlocked. When the lock is released, the urging force (restoring force) of the puncture means 9 causes the needle-integrated sensor chip 7 to move rapidly and rapidly in the direction of the fingertip that is the object to be inspected, and the puncture needle 19 moves the fingertip. Puncture.

  FIG. 6B shows a state where the fingertip is punctured. At this time, the elastic body 74 at the tip of the needle integrated sensor chip 7 is deformed by the pressing force.

  After puncturing, the needle-integrated sensor chip 7 is pushed up by the restoring force of the deformed elastic body 74, and the puncture needle 19 is pulled out. By this extraction, blood (sample) flows out from the object to be examined. FIG. 6C shows a state in which the deformed elastic body 74 is restored, the puncture needle 19 is pulled out, and blood (sample) flows out. The puncture needle 19 may be pulled out by using a force such as a pulling spring or an air damper other than the restoring force of the elastic body 74.

  In the case of pulling up by a spring, for example, a spring having a smaller spring constant than that of a spring as a puncturing means is used, and this spring is stretched during puncturing and generates a biasing force in a direction opposite to the puncturing direction. Can be pulled up.

  The blood (sample) that has flowed out is introduced into the sample introduction hole 75 by capillarity (therefore, it is desirable that the sample introduction hole 75 is subjected to a hydrophilic treatment), and further, the reaction unit 14 connected thereto. To cause a reaction for measurement. FIG. 6D shows a state in which blood (sample) is introduced into the sample introduction hole 75 and the reaction part 14.

  A signal generated by the reaction in the reaction unit 14 is detected by the electrode 16 and is output to the data processing unit through the electrode 61 which is in conduction therewith. The data processing unit performs data processing based on the signal, and the result is displayed on the display unit 3 including a liquid crystal display device.

  After the measurement, the used sensor chip is removed from the inside of the apparatus. However, as described above, the sensor chip may be removed from the inspected object contact opening 12.

  In the example shown in FIGS. 1 to 6, the opening of the opening / closing part 17 and the unlocking by the locking means 58 and 91 are performed by the operation button 8. First, when the operation button 8 is lightly pressed, the opening / closing portion 17 is opened (or the locking means 58 is released when the decompression pump of FIG. 4 is used), and the hermetic decompression chamber 11 is decompressed. Thereafter, when the operation button 8 is further pushed downward, the locking by the locking means 91 is released and puncture is performed. Then, by depressing the operation button 8 further downward, the decompression is released.

  As described above, the operation button 8 has three functions, but if one button has multiple functions, the possibility of erroneous operation increases. For example, the operation button 8 only opens the opening / closing portion 17 and is locked. The release of the means 91 may be performed by another button provided on the side surface of the apparatus main body.

  FIG. 7 is an external view showing another example of the sensor chip measuring apparatus of the present invention. In this example, the display unit 23 is provided in the apparatus main body 21, and the lid 22 covers only a part of one side of the apparatus main body 21, and rotates around a hinge 24 provided in the lower part of the apparatus main body 21. Move. The function of the lid 22 is the same as that of the lid 2 of the example shown in FIGS. 1 to 6, and the sensor chip is mounted by opening the lid 22. Since the lid 22 has a small area, it is difficult to mount the sensor chip, but it is preferable to keep the airtight decompression chamber airtight. Reference numeral 28 in the figure denotes an operation button, which has the same function as the operation button 8 in the example shown in FIGS.

  1 to 6 and the example shown in FIG. 7, the lids 2 and 22 may be provided on the back surface of the apparatus main body (the surface without the display units 3 and 23). Good. Further, when the sensor chip used for the measurement is formed into a magazine, the lid is not opened and closed every time measurement is performed, so it is necessary to provide another means for pressing the connector 6 and the urging plate 56. . Examples of such means include a cocking lever provided on the side surface of the main body, a piston rod that protrudes from the main body and connects the urging plate 56 and the like.

1 is an external view of a sensor chip measuring apparatus according to the present invention. It is a figure which shows the apparatus inside of the sensor chip measuring apparatus which concerns on this invention. It is sectional drawing which shows an example of the pressure reduction pump used by this invention, and its peripheral part. It is sectional drawing which shows the other example of the pressure reduction pump used by this invention, and its peripheral part. It is sectional drawing which shows a sensor chip mounting part, a sensor chip, a to-be-inspected object contact port, and those peripheral parts. It is sectional drawing which shows a sensor chip mounting part, a sensor chip, a to-be-inspected object contact port, and those peripheral parts for every process of use. It is a figure which shows the other example of the sensor chip measuring apparatus of this invention.

Explanation of symbols

1 21 Device body 2 22 Lid 3 23 Display unit 4 24 Hinge 6 Connector 7 Needle-integrated sensor chip 8 28 Operation button 9 Puncture means 11 Airtight decompression chamber 12 Test object contact port 14 Reaction unit 15 Decompression pump 16 Electrode 17 Opening / closing unit 18 Drug 19 Puncture needle 20 Positioning ring 21 Tip guide 51 Opening 52 Cylinder 53 Piston 54 Biasing spring 55 Rod 56 Biasing plate 57 Intake pipe 58 91 Locking means 61 Electrode 62 Sensor chip clamping part 71 Sensor chip main body 72 Puncture Needle fixing part 73 Casing 74 Elastic body 75 Sample introduction hole 92 Locking lever

Claims (7)

A sensor chip measuring device using a needle integrated sensor chip,
Mounting portion of the needle integrated sensor chip,
An airtight decompression chamber for housing the mounting portion;
Decompression means for decompressing the hermetic decompression chamber;
A lid of the hermetic decompression chamber that is openably and closably attached to the hermetic decompression chamber;
A test object contact port provided in the hermetic decompression chamber and opened outside the sensor chip measuring device;
A puncturing means for puncturing the object to be inspected by the needle-integrated sensor chip, and a data processing section for processing an output from the needle-integrated sensor chip;
A sensor chip measuring device comprising:   The puncturing means includes a spring and a compression means thereof, and the puncturing is performed by moving the needle-integrated sensor chip in the direction of the test object contact opening by releasing the compressed state of the spring. The sensor chip measuring apparatus according to claim 1.   3. The sensor chip measuring apparatus according to claim 2, wherein the spring compression means is operated by opening and closing a lid of the hermetic decompression chamber.   The sensor chip measuring device according to any one of claims 1 to 3, wherein the pressure reducing means comprises a pressure reducing pump that operates by opening and closing a lid of the hermetic pressure reducing chamber.   The sensor chip measuring apparatus according to claim 2, further comprising an operating unit that protrudes outside the sensor chip measuring apparatus, wherein the compression state of the spring is released by operating the operating unit.   6. The operation according to claim 1, further comprising operating means protruding outside the sensor chip measuring device, wherein the pressure reduction in the hermetic decompression chamber is performed by operating the operating means. Sensor chip measuring device.   The sensor chip measuring apparatus according to claim 1, wherein the data processing unit is provided in a lid of the hermetic decompression chamber.

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