JP4711333B2 - Measurement display and blood glucose measurement display - Google Patents

Measurement display and blood glucose measurement display Download PDF

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JP4711333B2
JP4711333B2 JP2005187584A JP2005187584A JP4711333B2 JP 4711333 B2 JP4711333 B2 JP 4711333B2 JP 2005187584 A JP2005187584 A JP 2005187584A JP 2005187584 A JP2005187584 A JP 2005187584A JP 4711333 B2 JP4711333 B2 JP 4711333B2
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blood glucose
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和彦 石尾
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Gunze Ltd
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Description

本発明は、着脱自在なバイオセンサを取り付けて使用し、該バイオセンサによる計測値を温度補正するための温度センサを、外郭体内に内蔵した計測表示器、及び血糖値計測表示器に関する。 The present invention relates to a measurement display device in which a detachable biosensor is attached and used, and a temperature sensor for correcting the temperature of a measurement value by the biosensor is built in an outer shell, and a blood glucose level measurement display device.

従来から、検体の血糖値等を測定するバイオセンサが使用されている（例えば、特許文献１及び特許文献２参照。）。このバイオセンサによれば、血糖値計測表示器に取り付けて検体を取り込み、血糖値計測表示器が血糖値等を計測表示することにより、血糖値等を認識できる。ここで、バイオセンサによる測定値は、その温度依存性により、周囲の温度が低い場合には実際よりも低く検知し、周囲の温度が高い場合には実際よりも高く検知することが知られている。   Conventionally, biosensors for measuring blood sugar levels and the like of specimens have been used (see, for example, Patent Document 1 and Patent Document 2). According to this biosensor, the blood sugar level and the like can be recognized by attaching the sample to the blood sugar level measuring display and taking in the sample, and the blood sugar level measuring and displaying the measurement display of the blood sugar level and the like. Here, it is known that the measured value by the biosensor is detected lower than the actual value when the ambient temperature is low, and higher than the actual value when the ambient temperature is high due to its temperature dependence. Yes.

このため、従来より、血糖値計測表示器の外郭体内に温度センサを設け、温度が低い場合には計測値を高く補正し、温度が高い場合には計測値を低く補正する温度補正が行なわれている。図６に、この温度センサ１を示す。この温度センサ１は、血糖値計測表示器２の外郭体３内の基盤４に内蔵されており、周辺の温度を測定することができる。なお、基盤の構成から温度センサ１の端子の位置が中心線５上に定まることから、温度センサ１は中心線５上に位置することとなる。   For this reason, conventionally, a temperature sensor is provided in the outer body of the blood sugar level measurement display, and when the temperature is low, the measurement value is corrected to be high, and when the temperature is high, temperature correction is performed to correct the measurement value low. ing. FIG. 6 shows the temperature sensor 1. The temperature sensor 1 is built in the base 4 in the outer body 3 of the blood sugar level measurement display 2 and can measure the ambient temperature. In addition, since the position of the terminal of the temperature sensor 1 is determined on the center line 5 from the configuration of the base, the temperature sensor 1 is positioned on the center line 5.

しかし、涼しい部屋に保管していた計測表示器を暑い場所へ持って行って血糖値を測定した場合、暑い部屋の温度を実際よりも低く検知して温度補正するため、正しい血糖値よりも高めに計測表示してしまうこととなっていた。一方、暑い部屋から涼しい部屋へ持って行って血糖値を測定した場合、反対に、正しい血糖値よりも低めに計測表示してしまうこととなっていた。   However, if you take a measurement indicator that was stored in a cool room and take it to a hot place to measure the blood sugar level, the temperature of the hot room will be detected lower than the actual temperature and the temperature will be corrected. It was supposed to display the measurement. On the other hand, when a blood glucose level is measured by taking it from a hot room to a cool room, the measurement is displayed lower than the correct blood glucose level.

特公平８−１０２０８号公報Japanese Patent Publication No.8-10208 特開平１０−１９８８８号公報Japanese Patent Laid-Open No. 10-1988

そこで、本発明者は、このような課題の原因を究明してこのような課題を解決するべく、鋭意研究を重ねた結果、本発明に至ったのである。   Therefore, the inventor of the present invention has come to the present invention as a result of intensive studies to investigate the cause of such a problem and solve such a problem.

すなわち、本発明は、より正確に計測表示するために、周辺の温度をより正確に検知してより正しく温度補正できる計測表示器、及び血糖値計測表示器を提供することを目的とする。 That is, an object of the present invention is to provide a measurement display device and a blood glucose level measurement display device that can detect the ambient temperature more accurately and correct the temperature more accurately in order to perform measurement display more accurately.

本発明に係る温度センサは、計測表示器に取り付けたバイオセンサによる計測値を温度補正するために該計測表示器の外郭体内に内蔵されている温度センサであり、前記外郭体内の基盤の端子から延びるリード線と、該リード線の先端に固定され、該端子よりも該外郭体に近接させた位置に配置されるセンサ素子と、から構成されたことを特徴とする。 The temperature sensor according to the present invention is a temperature sensor built in the outer body of the measurement display device for correcting the temperature of the measurement value of the biosensor attached to the measurement display device. It is characterized by comprising a lead wire that extends and a sensor element that is fixed to the tip of the lead wire and disposed at a position closer to the outer body than the terminal.

また、本発明に係る温度センサは、前記温度センサにおいて、前記センサ素子が、前記外郭体の内面に密着させられることを特徴とする。 The temperature sensor according to the present invention is characterized in that, in the temperature sensor, the sensor element is in close contact with an inner surface of the outer body.

また、本発明に係る温度センサは、前記温度センサにおいて、前記リード線が、前記外郭体内の空間内で延びることを特徴とする。 The temperature sensor according to the present invention is characterized in that, in the temperature sensor, the lead wire extends in a space in the outer body.

また、本発明に係る温度センサは、前記温度センサにおいて、前記リード線が、前記端子から外側に向かって延びた後湾曲して前記バイオセンサの取付部付近に向かうことを特徴とする。 The temperature sensor according to the present invention is characterized in that, in the temperature sensor, the lead wire extends outward from the terminal and then curves toward the biosensor mounting portion.

また、本発明に係る温度センサは、前記温度センサにおいて、前記リード線が弾性を有することを特徴とする。 The temperature sensor according to the present invention is characterized in that in the temperature sensor, the lead wire has elasticity.

また、本発明に係る温度センサは、前記温度センサにおいて、前記計測表示器が血糖値計測表示器であることを特徴とする。 The temperature sensor according to the present invention is characterized in that, in the temperature sensor, the measurement display is a blood glucose level measurement display.

本発明の計測表示器は、前記温度センサを備えたことを特徴とする。   The measurement display of the present invention is characterized by comprising the temperature sensor.

本発明の血糖値計測表示器は、前記温度センサを備えたことを特徴とする。   The blood glucose level measurement display of the present invention is characterized by comprising the temperature sensor.

本発明の計測表示器、及び血糖値計測表示器によれば、温度センサを外郭体内に内蔵しながらも、センサを外郭体に近接させた位置に配置することができる。このため、外郭体内に溜まった空気の熱又は基盤から生じる熱の影響を最小限にして、周辺の温度を従来よりも正確に検知できる。このため、従来よりも正しく温度補正して従来よりも正確に計測表示することができる。 According to the measurement display device and the blood glucose level measurement display device of the present invention, it is possible to arrange the sensor close to the outer body while the temperature sensor is built in the outer body. For this reason, the influence of the heat of the air accumulated in the outer body or the heat generated from the base can be minimized, and the ambient temperature can be detected more accurately than before. For this reason, it is possible to correct and correct the temperature more accurately than in the past and to display the measurement more accurately than in the past.

また、センサ素子が外郭体の内面に密着させられる本発明によれば、外郭体を介して周辺の温度を従来よりも正確に測定することができる。更に、リード線が弾性を有する本発明の場合には、リード線の弾性力によって容易にセンサ素子を外郭体の内面に密着させることができる。   Further, according to the present invention in which the sensor element is brought into close contact with the inner surface of the outer body, the ambient temperature can be measured more accurately than in the past through the outer body. Furthermore, in the case of the present invention in which the lead wire has elasticity, the sensor element can be easily adhered to the inner surface of the outer body by the elastic force of the lead wire.

また、リード線が外郭体内の空間内で延びる本発明の場合には、リード線先端のセンサ素子を自由に最適な位置に配置することができる。更に、リード線が、前記端子から外側に向かって延びた後湾曲して前記バイオセンサの取付部付近に向かう本発明の場合には、センサ素子を容易にバイオセンサの取付部付近に配置して、バイオセンサ周辺の温度を検知することができる。   In the case of the present invention in which the lead wire extends in the space in the outer shell, the sensor element at the tip of the lead wire can be freely arranged at an optimal position. Furthermore, in the case of the present invention in which the lead wire extends outward from the terminal and then bends toward the biosensor mounting portion, the sensor element is easily disposed near the biosensor mounting portion. The temperature around the biosensor can be detected.

次に、本発明に係る温度センサ、血糖値計測表示器の形態について、図面に基づいて詳しく説明する。   Next, embodiments of a temperature sensor and a blood glucose level measurement display according to the present invention will be described in detail based on the drawings.

図１及び図２において、符号１０は本発明に係る温度センサであり、符号１２は本発明の血糖値計測表示器である。 1 and 2, reference numeral 10 is a temperature sensor according to the present invention, reference numeral 12 is a blood glucose level measuring indicator of the present invention.

温度センサ１０は、血糖値計測表示器（計測表示器）１２に取り付けたバイオセンサ１４による計測値を温度補正するために血糖値計測表示器１２の外郭体１８内に内蔵されている温度センサであり、外郭体１８内のＣＰＵ基盤２０の端子２２から延びるリード線２４と、リード線２４の先端に固定され、端子２２よりも外郭体１８に近接させた位置即ち端子２２よりも外側に配置されるセンサ素子２６と、から構成されている。なお、端子２２の位置は、ＣＰＵ２１の配置やＣＰＵ基盤２０の構造等によって、中心線２３付近に定まっている。 The temperature sensor 10 is a temperature sensor built in the outer body 18 of the blood glucose level measurement display 12 in order to correct the temperature of the measurement value by the biosensor 14 attached to the blood glucose level measurement display (measurement display) 12. There is a lead wire 24 extending from the terminal 22 of the CPU base 20 in the outer body 18 and fixed to the tip of the lead wire 24, and is disposed at a position closer to the outer body 18 than the terminal 22, ie, outside the terminal 22. Sensor element 26. The position of the terminal 22 is determined in the vicinity of the center line 23 depending on the arrangement of the CPU 21 and the structure of the CPU base 20.

また、温度センサ１０は、センサ素子１６が、外郭体１８の内面に密着させられるように構成され、外郭体１８内に内蔵されながらも、外郭体１８の側壁を介して血糖値計測表示器１２の周辺温度を最大限に正確に検知できるように構成されている。センサ素子１６の原材料は、外郭体１８内に配置できるとともに温度を検知できるものであれば特に限定されない。   Further, the temperature sensor 10 is configured such that the sensor element 16 is brought into close contact with the inner surface of the outer body 18, and is incorporated in the outer body 18, but the blood sugar level measurement display 12 is provided via the side wall of the outer body 18. It is configured so that the ambient temperature can be detected with maximum accuracy. The raw material of the sensor element 16 is not particularly limited as long as it can be disposed in the outer body 18 and can detect the temperature.

温度センサ１２のリード線２４は、外郭体１８内の空間内で延びることにより、センサ素子１６を最適な位置に自由に配置できるとともに、ＣＰＵ基盤２０の熱の影響が最小限になるように構成されている。このリード線２４は、端子２２から一旦外へ延びた後湾曲してバイオセンサ１４の取付部１５付近に向かう形状となっている。また、リード線２４は、弾性を有しており、センサ素子１６を最適な位置に自由に配置できるとともに、弾性力によってセンサ素子１６が外郭体１８の内面に密着させられるように構成されている。なお、リード線２４は、ＣＰＵ２１が発する熱の影響を最小源にするために、中心線２３に対してＣＰＵ２１と反対側へ延びることが望ましい。このリード線２４の材質は、センサ素子１６による温度検知が可能であれば特に限定されない。   The lead wire 24 of the temperature sensor 12 extends in the space in the outer body 18 so that the sensor element 16 can be freely arranged at an optimum position and the influence of the heat of the CPU base 20 is minimized. Has been. The lead wire 24 has a shape that extends from the terminal 22 to the outside and then curves toward the attachment portion 15 of the biosensor 14. Further, the lead wire 24 has elasticity, and the sensor element 16 can be freely arranged at an optimum position, and is configured so that the sensor element 16 is brought into close contact with the inner surface of the outer body 18 by elastic force. . Note that the lead wire 24 preferably extends to the opposite side of the CPU 21 with respect to the center line 23 in order to minimize the influence of heat generated by the CPU 21. The material of the lead wire 24 is not particularly limited as long as the sensor element 16 can detect the temperature.

このような温度センサ１０、及びこの温度センサ１０を備える血糖値計測表示器１２の作用について以下に説明する。   The operation of such a temperature sensor 10 and a blood glucose level measurement indicator 12 including this temperature sensor 10 will be described below.

この温度センサ１０は、外郭体１８の下蓋を取り外した場合には、図２に示すように、外郭体１８の外へ突出することとなる。このため、手で温度センサ１０のセンサ素子１６付近を保持し、外郭体１８内に収まるように外郭体１８内へ弾性的に折り曲げて下蓋を閉じる。これにより、図１に示すように、センサ素子１６が外郭体１８の内面に密着した状態で温度センサ１０が外郭体１８内に収められる。なお、温度センサ１０のリード線２４は、端子２２から一旦外へ延びた後湾曲してバイオセンサ１４の取付部付近に向かう形状となっているため、センサ素子１６を容易にバイオセンサ１４付近に配置できる。このため、バイオセンサ１４付近の温度を検知して、バイオセンサ１４の温度依存性を適確に補正することができる。   When the lower cover of the outer body 18 is removed, the temperature sensor 10 protrudes out of the outer body 18 as shown in FIG. Therefore, the vicinity of the sensor element 16 of the temperature sensor 10 is held by hand, and the lower lid is closed by elastically bending into the outer body 18 so as to be within the outer body 18. As a result, as shown in FIG. 1, the temperature sensor 10 is housed in the outer body 18 with the sensor element 16 being in close contact with the inner surface of the outer body 18. The lead wire 24 of the temperature sensor 10 has a shape that once extends outward from the terminal 22 and then bends toward the vicinity of the attachment portion of the biosensor 14, so that the sensor element 16 can be easily placed near the biosensor 14. Can be placed. For this reason, the temperature in the vicinity of the biosensor 14 can be detected, and the temperature dependence of the biosensor 14 can be accurately corrected.

このようにして、温度センサ１０が外郭体１８内に収められた状態で、バイオセンサ１４を取り付け、バイオセンサ１４を血液に接触させて血糖値の計測が行なわれる。この時、温度センサ２０が周辺の温度を検知し、ＣＰＵ基盤２０は血糖値の温度補正を行なって表示画面２６に表示する。すなわち、温度センサ１０が一定温度以上の温度を検知した場合には、血糖値を低く補正し、一定温度未満の温度を検知した場合には、血糖値を高く補正する。   In this manner, in a state where the temperature sensor 10 is housed in the outer body 18, the biosensor 14 is attached, and the blood glucose level is measured by bringing the biosensor 14 into contact with blood. At this time, the temperature sensor 20 detects the ambient temperature, and the CPU board 20 corrects the blood sugar level and displays it on the display screen 26. That is, when the temperature sensor 10 detects a temperature equal to or higher than a certain temperature, the blood sugar level is corrected low, and when a temperature lower than the certain temperature is detected, the blood sugar level is corrected high.

本発明によれば、温度センサ１０のセンサ素子１６がＣＰＵ基盤２０から浮かせられているとともに、外郭体１８の内面に密着させられているため、外郭体１８内に溜まった空気の熱又はＣＰＵ２１やＣＰＵ基盤２０の熱に影響されることなく、周辺の温度を従来よりも正確に検知することができる。このため、従来よりも正しい温度補正を行なって従来よりも正確な血糖値表示を行なうことができる。   According to the present invention, since the sensor element 16 of the temperature sensor 10 is floated from the CPU base 20 and is in close contact with the inner surface of the outer body 18, the heat of the air accumulated in the outer body 18 or the CPU 21 or The ambient temperature can be detected more accurately than before without being affected by the heat of the CPU board 20. For this reason, it is possible to perform more accurate temperature correction than before and display blood glucose level more accurately than before.

この温度センサ１０を備えた血糖値計測表示器１２を用いて本発明者が実際に試験を行なった結果を図３及び図４に示す。例えば血糖値計測表示器１２を２０℃の室内から３０℃の室内へ移動させて１０分経過した場合、図３に示すように、従来は約３．２℃の温度測定誤差があることにより、約１０ｍｇ／ｄＬの血糖値表示誤差があったのに対して、本発明の温度センサ１０を備えた場合には、約１．２℃の温度誤差及び約４ｍｇ／ｄＬの血糖値表示誤差に改善された。また、例えば３０℃の室内から２０℃の室内へ移動させて１０分経過した場合、図４に示すように、従来は約３．７℃の温度測定誤差があることにより、約１５ｍｇ／ｄＬの血糖値表示誤差があったのに対して、本発明の温度センサ１０を備えた場合には、約１．８℃の温度誤差及び約７ｍｇ／ｄＬの血糖値表示誤差に改善された。   3 and 4 show the results of actual tests performed by the present inventor using the blood glucose level measurement display 12 equipped with the temperature sensor 10. FIG. For example, when the blood glucose level measurement indicator 12 is moved from the room at 20 ° C. to the room at 30 ° C. for 10 minutes, as shown in FIG. 3, there is a temperature measurement error of about 3.2 ° C. In contrast to the blood glucose level display error of about 10 mg / dL, the temperature sensor 10 of the present invention improves the temperature error to about 1.2 ° C. and the blood glucose level display error of about 4 mg / dL. It was done. Further, for example, when 10 minutes have passed after moving from a room of 30 ° C. to a room of 20 ° C., as shown in FIG. 4, there is a temperature measurement error of about 3.7 ° C. While there was a blood sugar level display error, the temperature sensor 10 of the present invention was improved to a temperature error of about 1.8 ° C. and a blood sugar level display error of about 7 mg / dL.

以上、本発明の一実施形態について説明したが、本発明は上述の実施形態には限定されない。例えば、本発明の血糖値計測表示器１２において、図５に示すように、センサ素子１６の収納空間３０を積極的に設けても良い。この場合、センサ素子１６を外郭体１８内に容易に収納できる。この場合、リード線が弾性力を有しなくとも、センサ素子を外郭体の内面に密着させて固定できる。   Although one embodiment of the present invention has been described above, the present invention is not limited to the above-described embodiment. For example, in the blood sugar level measurement display 12 of the present invention, the storage space 30 for the sensor element 16 may be positively provided as shown in FIG. In this case, the sensor element 16 can be easily accommodated in the outer body 18. In this case, even if the lead wire does not have elasticity, the sensor element can be fixed in close contact with the inner surface of the outer body.

以上、本発明の実施形態について図面に基づいて説明したが、本発明は図示したものには限定されない。例えば、本発明の用途は、血糖値の検査に限定されず、広く、医学的、生物学的、化学的な検査又は試験等であっても良い。また、血糖値以外の血液検査であっても良い。また、センサ素子や外郭体の形状は、本発明の作用効果が生じれば特に限定されない。   As mentioned above, although embodiment of this invention was described based on drawing, this invention is not limited to what was illustrated. For example, the application of the present invention is not limited to blood glucose level testing, and may be widely used for medical, biological, chemical testing or testing. Moreover, blood tests other than blood sugar levels may be used. In addition, the shape of the sensor element and the outer body is not particularly limited as long as the effect of the present invention occurs.

その他、本発明の技術的範囲には、その趣旨を逸脱しない範囲で当業者の知識に基づき種々なる改良、修正、変形を加えた態様も含まれる。また、同一の作用又は効果が生じる範囲内で、いずれかの発明特定事項を他の技術に置換した形態で実施しても良い。   In addition, the technical scope of the present invention includes embodiments in which various improvements, modifications, and variations are added based on the knowledge of those skilled in the art without departing from the spirit of the present invention. Moreover, you may implement with the form which substituted any invention specific matter to the other technique within the range which the same effect | action or effect produces.

本発明の計測表示器、及び血糖値計測表示器は、周辺の温度を従来よりも正確に検知し、従来よりも正しく温度補正して従来よりも正確に計測表示することができる。このため、バイオセンサによる計測のために広く利用できる。 The measurement display device and blood glucose level measurement display device of the present invention can detect the ambient temperature more accurately than before, correct the temperature more correctly than before, and display the measurement more accurately than before. For this reason, it can be widely used for measurement by a biosensor.

本発明の温度センサ及び血糖値計測表示器を示す図であり、同図（ａ）は平面図であり、同図（ｂ）はＡ−Ａ線切断部断面図である。It is a figure which shows the temperature sensor and blood glucose level measurement display of this invention, the figure (a) is a top view, and the figure (b) is an AA cut | disconnection cross-sectional view. 図１の血糖値計測表示器の底面図である。It is a bottom view of the blood glucose level measurement display of FIG. 図１の温度センサ及び血糖値計測表示器について周辺の温度が上昇した場合の試験結果を示す図であり、同図（ａ）は温度測定誤差を従来と比較したグラフであり、同図（ｂ）は表示誤差を従来と比較したグラフである。It is a figure which shows the test result when the surrounding temperature rises about the temperature sensor and blood glucose level measurement display of FIG. 1, The figure (a) is a graph which compared the temperature measurement error with the past, and the figure (b) ) Is a graph comparing the display error with the conventional one. 図１の温度センサ及び血糖値計測表示器について周辺の温度が下降した場合の試験結果を示す図であり、同図（ａ）は温度測定誤差を従来と比較したグラフであり、同図（ｂ）は表示誤差を従来と比較したグラフである。It is a figure which shows the test result when the surrounding temperature falls about the temperature sensor of FIG. 1, and a blood glucose level measurement display, The figure (a) is a graph which compared the temperature measurement error with the past, and the figure (b) ) Is a graph comparing the display error with the conventional one. 本発明の温度センサ及び血糖値計測表示器の他の実施形態を示す平面図である。It is a top view which shows other embodiment of the temperature sensor of this invention, and a blood glucose level measurement display. 従来の温度センサ及び血糖値計測表示器を示す平面図である。It is a top view which shows the conventional temperature sensor and a blood glucose level measurement display.

１０：温度センサ
１２：血糖値計測表示器（計測表示器）
１４：バイオセンサ
１６：センサ素子
１８：外郭体
２０：ＣＰＵ基盤（基盤）
２１：ＣＰＵ
２２：端子
２４：リード線 10: Temperature sensor 12: Blood glucose level measurement display (measurement display)
14: Biosensor 16: Sensor element 18: Outer body 20: CPU base (base)
21: CPU
22: Terminal 24: Lead wire

Claims (4)

着脱自在なバイオセンサを取り付けて使用し、該バイオセンサによる計測値を温度補正するための温度センサを、外郭体内に内蔵した計測表示器であり、
前記温度センサが、
前記外郭体内の基盤の端子から延びるリード線と、
該リード線の先端に固定され、前記外郭体の内面に密着させられるセンサ素子と、
から構成された計測表示器。 It is a measurement indicator that uses a detachable biosensor attached, and a temperature sensor for correcting the temperature of the measurement value of the biosensor in the outer body.
The temperature sensor is
A lead wire extending from a terminal of the base in the outer body;
A sensor element fixed to the leading end of the lead wire and closely attached to the inner surface of the outer body ;
A measurement indicator composed of 血糖値計測表示器である請求項１に記載する計測表示器。   The measurement display according to claim 1, which is a blood glucose level measurement display. 前記センサ素子が、前記外郭体の内面に設けられた収納空間に収納される請求項１または２に記載する計測表示器。The measurement display according to claim 1 or 2, wherein the sensor element is stored in a storage space provided on an inner surface of the outer body. 前記リード線が、前記端子から外側に向かって延びた後湾曲して前記バイオセンサの取付部付近に向かう請求項１から３のいずれかに記載する計測表示器。 The measurement display according to any one of claims 1 to 3 , wherein the lead wire extends outward from the terminal and then bends toward the biosensor mounting portion.
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