JP4697783B2 - Sample detection extraction container - Google Patents

Sample detection extraction container Download PDF

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Publication number
JP4697783B2
JP4697783B2 JP2005221964A JP2005221964A JP4697783B2 JP 4697783 B2 JP4697783 B2 JP 4697783B2 JP 2005221964 A JP2005221964 A JP 2005221964A JP 2005221964 A JP2005221964 A JP 2005221964A JP 4697783 B2 JP4697783 B2 JP 4697783B2
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container
cylinder
nozzle
extraction container
extraction
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JP2007040710A (en
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正 今村
宗徳 佐藤
正幸 椛島
聡 池田
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KITAMURA CHEMICALS CO.,LTD.
Mizuho Medy Co Ltd
Mikasa Sangyo Co Ltd
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KITAMURA CHEMICALS CO.,LTD.
Mizuho Medy Co Ltd
Mikasa Sangyo Co Ltd
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Description

本発明は、患者が感染症にかかっているかどうかを検出するための、検体検出用抽出容器に関するものである。   The present invention relates to a specimen detection extraction container for detecting whether a patient has an infection.

医師等の検査者は、インフルエンザウイルス、アデノウイルス、RSウイルス等の感染症にかかっているかどうかを検出するために、検体検査を行う。この検査には、検体検出用抽出容器とアッセイストリップとの組み合わせが用いられ、例えば、コンタミネーションの発生を防止する、次の様な検体検出用抽出容器が使用されている。(例えば、特許文献1、参照)。
内部に検体抽出試薬を溜める液溜部と、前記抽出試薬を滴下するノズル部とを一体的に形成して容器本体となし、前記液溜部は、可撓性を有するとともに局所(例えば、鼻腔あるいは咽頭)に接触させた綿棒を挿入できるように形成され、前記ノズル部は、前記液溜部よりも小径に形成され、前記液溜部と前記ノズル部との間にフイルタ座を形成し、前記フイルタ座に前記抽出試薬を濾過するフイルタを装着し、前記ノズル部の周囲をノズル封止キャップで開閉可能に封止した検体検出用抽出容器。
An inspector such as a doctor performs a sample test to detect whether or not the patient has an infectious disease such as influenza virus, adenovirus, or RS virus. For this test, a combination of an extraction container for sample detection and an assay strip is used. For example, the following sample detection extraction container that prevents the occurrence of contamination is used. (For example, refer to Patent Document 1).
A liquid reservoir for storing the sample extraction reagent and a nozzle for dripping the extraction reagent are integrally formed to form a container body. The liquid reservoir is flexible and locally (for example, nasal cavity) Or a swab in contact with the pharynx), the nozzle part is formed with a smaller diameter than the liquid reservoir, and a filter seat is formed between the liquid reservoir and the nozzle part, A sample detection extraction container in which a filter for filtering the extraction reagent is attached to the filter seat, and the periphery of the nozzle portion is sealed with a nozzle sealing cap so as to be opened and closed.

実用新案登録第3107824号公報Utility Model Registration No. 3107824

従来例には、次のような問題がある。
(1)検査者は、予め検体抽出試薬が収容されている液溜部に、患者の局所に接触させた綿球を挿入して、綿球に吸着しているぬぐい液を検体抽出試薬と混合後、アッセイストリップへの滴下作業をおこなうが、綿球を挿入する前に前記液溜部の試薬がフイルタを通って小径部に少量流下して溜まってしまう。そのため、ノズル封止キャップを外して、アッセイストリップにノズルから滴下する最初の数滴は、ぬぐい液の混じっていない試薬が注出されるので、検査者は最初の数滴を捨てる工程を経た後、アッセイストリップへ滴下しなければならない。
The conventional example has the following problems.
(1) The examiner inserts a cotton ball in contact with the patient's local area into the liquid reservoir that contains the sample extraction reagent in advance, and mixes the wipes adsorbed on the cotton ball with the sample extraction reagent. After that, the dropping operation to the assay strip is performed, but before inserting the cotton ball, the reagent in the liquid reservoir passes through a filter and flows down to a small diameter portion and accumulates. Therefore, after removing the nozzle sealing cap, the first few drops dropped from the nozzle onto the assay strip are dispensed with a reagent that is not mixed with wiping fluid, so the tester goes through the process of discarding the first few drops, Must be dripped onto the assay strip.

(2)容器本体に上キャップが螺着されているため、検査時には、前記上キャップを回して該容器本体に着脱しなければならないので、面倒である。又、上キャップを外したときに、該上キャップを無くしたり、又は、該上キャップにゴミ等が付着しやすい等衛生上の問題がある。
(3)容器本体に上キャップが螺着されているため、螺着が緩んだ場合、螺着部から液溜部内の検体抽出試薬が漏れる虞がある。
(2) Since the upper cap is screwed to the container main body, it is troublesome because the upper cap must be turned and detached from the container main body at the time of inspection. In addition, when the upper cap is removed, there is a problem in hygiene such that the upper cap is lost or dust or the like easily adheres to the upper cap.
(3) Since the upper cap is screwed to the container main body, if the screwing is loosened, there is a possibility that the sample extraction reagent in the liquid reservoir will leak from the screwed portion.

この発明は、上記事情に鑑み、ぬぐい液が混じった検体抽出試薬をアッセイストリップへ滴下する際に、最初の数滴を捨てる工程を省略できる検体検出用抽出容器を提供することを目的とする。他の目的は、検査者の使い勝手を向上するとともに、液漏れが発生しない検体検出用抽出容器を提供することを目的とする。   In view of the above circumstances, an object of the present invention is to provide an extraction container for sample detection that can omit the step of discarding the first few drops when a sample extraction reagent mixed with a wiping solution is dropped onto an assay strip. Another object of the present invention is to provide an extraction container for specimen detection that improves the convenience of the examiner and does not cause liquid leakage.

この発明は、予め検体抽出試薬が収容された容器本体と、該容器本体の口部に装着される蓋体とからなる検体検出用抽出容器であって;前記蓋体は、前記容器本体の口部を閉鎖する中栓と、該中栓にヒンジを介して連結されたノズル筒とを備えており、前記中栓の頂壁には、前記ノズル筒を前記ヒンジを中心に回転させることにより露出し、ぬぐい液が付着した綿球が挿入される綿棒挿入口を当該頂壁に開口するための開口手段が設けられ、前記ノズル筒の内側には、フイルタが挿着され、その外側には、ノズル封止キャップが着脱容易なスナップ係合等の手段により被着されていることを特徴とする。 The present invention is an extraction container for detecting a sample comprising a container main body in which a sample extraction reagent is stored in advance, and a lid attached to the mouth of the container main body; the lid is a mouth of the container main body And a nozzle cylinder connected to the inner plug via a hinge. The top wall of the inner plug is exposed by rotating the nozzle cylinder around the hinge. In addition, an opening means for opening a cotton swab insertion opening into which the cotton ball with the wiping solution is inserted is provided in the top wall, and a filter is inserted inside the nozzle cylinder, The nozzle sealing cap is attached by means such as snap engagement which can be easily attached and detached.

この発明の中栓は、容器口部の外周面に螺着される外筒と、該外筒に連続し、前記容器口部の内面に当接する内筒と、を備えており、ノズル筒は、ヒンジが連結される中栓当接筒部と、該中栓当接筒部に連続し、フイルタが挿着されているノズル部とを備えていることを特徴とする。この発明の開口手段が、開口用突起であることを特徴とする。この発明の中栓当接筒部の内側に、シールリングが設けられていることを特徴とする。この発明の中栓の頂壁に、ノズル筒に係合する係止突起が立設されていることを特徴とする。この発明の容器本体は、可撓性を有することを特徴とする。この発明の容器本体は、透明、もしくは半透明であることを特徴とする。   The inner plug of the present invention includes an outer cylinder that is screwed to the outer peripheral surface of the container mouth portion, and an inner cylinder that is continuous with the outer cylinder and contacts the inner surface of the container mouth portion. The inner plug abutting cylinder part to which the hinge is connected, and the nozzle part which is continuous with the inner plug abutting cylinder part and into which a filter is inserted are provided. The opening means of the present invention is an opening protrusion. The present invention is characterized in that a seal ring is provided on the inner side of the inner stopper abutting tube portion. A locking projection that engages with the nozzle cylinder is provided on the top wall of the inner plug of the present invention. The container body of this invention is characterized by having flexibility. The container body of the present invention is characterized by being transparent or translucent.

この発明は、以上のように構成したので、容器本体を逆さにしてノズルを下向きにしたときに初めて、ぬぐい液が混じった検体抽出試薬がフイルタを通り、ノズル筒から滴下する。そのため、最初の液滴から、検査の対象にすることができる。従って、従来例と異なり、最初の数滴を捨てる工程を省略することができる。   Since the present invention is configured as described above, the sample extraction reagent mixed with the wiping liquid is dropped from the nozzle tube through the filter only when the container body is turned upside down and the nozzle is turned downward. Therefore, it is possible to make an inspection target from the first droplet. Therefore, unlike the conventional example, the step of discarding the first few drops can be omitted.

また、中栓とノズル筒とがヒンジ結合されているので、従来例と異なり、開けやすく、又、落下等の虞もなく衛生的である。
さらに、中栓は、外筒に連続し、前記口部の内面に当接する内筒を備えているので、検体抽出試薬が漏れるのを防止することができる。また、中栓当接筒部の内側に、シールリングを設けたので、この部分から検体抽出試薬が漏れるのを防止することができる。
さらに、容器本体を可撓性のものとしたので、ぬぐい液の搾り出しと、アッセイストリップへの滴下が容易になる。また容器本体を、透明もしくは半透明としたので視認性が良好となり、作業効率が改善される。
Further, since the inner plug and the nozzle cylinder are hinge-coupled, unlike the conventional example, it is easy to open and is hygienic without the risk of dropping.
Furthermore, since the inner plug includes an inner cylinder that is continuous with the outer cylinder and contacts the inner surface of the mouth, it is possible to prevent the specimen extraction reagent from leaking. Further, since the seal ring is provided inside the inner plug abutting tube portion, it is possible to prevent the specimen extraction reagent from leaking from this portion.
Furthermore, since the container body is made flexible, it is easy to squeeze the wiping solution and drop it onto the assay strip. Further, since the container body is transparent or translucent, the visibility is improved and the working efficiency is improved.

この発明の実施の形態を図1〜図3により説明する。
容器本体1は、合成樹脂により形成された薄肉で可撓性を有する、透明もしくは半透明な有底の円筒体である。容器本体の口部3外周には、ねじ部5が形成され、該ねじ部5の下部には、フランジ7が設けられている。
An embodiment of the present invention will be described with reference to FIGS.
The container body 1 is a thin, flexible, transparent or translucent bottomed cylindrical body made of synthetic resin. A screw portion 5 is formed on the outer periphery of the mouth portion 3 of the container body, and a flange 7 is provided at the lower portion of the screw portion 5.

容器本体1には、蓋体10が装着されている。蓋体10は、容器口部3に螺着される中栓12と、該中栓12とヒンジ14を介して連結されたノズル筒30とを備えている。   A lid 10 is attached to the container body 1. The lid 10 includes an inner plug 12 that is screwed into the container mouth portion 3, and a nozzle cylinder 30 that is connected to the inner plug 12 via a hinge 14.

前記中栓12は、外筒16と、該外筒16に頂壁17を介して連結されている内筒18と、該頂壁17の上面周縁側に形成された係止突起19と、該頂壁17の中央に形成された綿棒挿入口20と、を備えている。外筒16の内面には、容器口部のねじ部5と螺合するねじ部21が設けられており、その下端は、容器口部3のフランジ7に近接している。又、外筒16の外周面上端部には、指入れ凹部23が設けられている。   The inner plug 12 includes an outer cylinder 16, an inner cylinder 18 connected to the outer cylinder 16 via a top wall 17, a locking protrusion 19 formed on the upper peripheral edge of the top wall 17, A cotton swab insertion opening 20 formed in the center of the top wall 17. The inner surface of the outer cylinder 16 is provided with a screw portion 21 that is screwed with the screw portion 5 of the container mouth portion, and the lower end thereof is close to the flange 7 of the container mouth portion 3. A finger insertion recess 23 is provided at the upper end of the outer peripheral surface of the outer cylinder 16.

内筒18は、容器口部3の内周面に液密に当接する。綿棒挿入口20は、開口手段、例えば、開口用突起25により閉鎖されている。開口用突起25は、前記綿棒挿入口20の縁部に破断可能な薄肉部を介して連結されている円筒基部27と、該円筒基部27に連続する円柱部28とを備えている。なお、前記円柱部28の先端部には、面取部29が設けられている。   The inner cylinder 18 is in liquid-tight contact with the inner peripheral surface of the container mouth 3. The swab insertion opening 20 is closed by an opening means, for example, an opening protrusion 25. The opening protrusion 25 includes a cylindrical base portion 27 connected to an edge portion of the cotton swab insertion opening 20 via a thin portion that can be broken, and a columnar portion 28 that is continuous with the cylindrical base portion 27. A chamfered portion 29 is provided at the tip of the cylindrical portion 28.

ノズル筒30は、ヒンジ14が連結される中栓当接筒部31と、該中栓当接筒部31に連続し、フイルタ33が挿着されているノズル部35と、を備えている。前記中栓当接筒部31の内面は前記係止突起19に当接し、又、その内側には、シールリング36が立設されている。ノズル部35の中間部にはノズル収容部37が設けられ、該フィルタ収容部37には、フイルタ33が挿着されている。ノズル筒30の先端部には、ノズル封止キャップ38が被着されている。   The nozzle cylinder 30 includes an inner plug abutting cylinder part 31 to which the hinge 14 is connected, and a nozzle part 35 that is continuous with the inner plug abutting cylinder part 31 and into which a filter 33 is inserted. The inner surface of the inner plug abutting tube portion 31 abuts on the locking projection 19, and a seal ring 36 is erected on the inner side. A nozzle accommodating portion 37 is provided at an intermediate portion of the nozzle portion 35, and a filter 33 is inserted into the filter accommodating portion 37. A nozzle sealing cap 38 is attached to the tip of the nozzle cylinder 30.

次に、本実施の形態の作動について説明する。
容器本体1を手で握り、指入れ凹部23に指をかけて中栓12の指掛け部32を上方へ押し上げると、ノズル筒30はヒンジ14を中心に回転し、開口用突起25が露出する。この開口用突起25を指で摘んで押し倒すか、或いはノズル封止キャップ38をノズル部35から取り外し、開口用突起25に被せて押し倒すことにより、該開口用突起25の基部と綿棒挿入口20の縁部とを接続する薄肉部が裂き切れ、頂壁17から分離し、綿棒挿入口20が開口する。
Next, the operation of the present embodiment will be described.
When the container body 1 is grasped by hand and a finger is placed on the finger insertion recess 23 and the finger hooking portion 32 of the inner plug 12 is pushed upward, the nozzle cylinder 30 rotates around the hinge 14 and the opening projection 25 is exposed. The opening projection 25 is picked up by a finger and pushed down, or the nozzle sealing cap 38 is removed from the nozzle portion 35 and placed on the opening projection 25 and pushed down. The thin-walled portion connecting the edge portion is torn and separated from the top wall 17, and the cotton swab insertion opening 20 is opened.

綿棒40を手で持ち、患者の咽喉などの局所に綿球42を接触させてぬぐい液Sを採取する。   The swab 40 is held by hand, and the swab 42 is brought into contact with a local area such as the throat of the patient to collect the wiping fluid S.

次に図2に示すように、ぬぐい液Sが付着した綿球42を綿棒挿入口20に挿入し、検体抽出試薬Tに浸しながらよく攪拌する。その後、容器本体1の外側から綿球42を摘み、数回しごいて検体Sを良く搾り出す。   Next, as shown in FIG. 2, the cotton ball 42 to which the wiping solution S is attached is inserted into the cotton swab insertion slot 20 and stirred well while being immersed in the specimen extraction reagent T. Thereafter, the cotton ball 42 is picked from the outside of the container body 1 and squeezed several times to squeeze out the sample S well.

綿棒40を容器本体1から抜き出した後、ノズル筒30を指で掴み、ヒンジ14を中心に回転させ元の状態に戻す。この時、中栓当接筒部31の係合部34は、係止突起19に係止し、シールリング36の下端は頂壁17に液密に当接するので、液漏れの心配がない。   After extracting the cotton swab 40 from the container body 1, the nozzle cylinder 30 is grasped with a finger and rotated around the hinge 14 to return to the original state. At this time, the engaging portion 34 of the inner plug abutting tube portion 31 is engaged with the engaging projection 19 and the lower end of the seal ring 36 is in liquid-tight contact with the top wall 17, so there is no fear of liquid leakage.

ノズル封止キャップ38をノズル筒30から外した後、アッセイストリップ45の試料添加部46にぬぐい液Sと検体抽出試薬Tとの混合液Wを数滴滴下する。以降、アッセイストリップ45を用いて、検体を検出し、陽性/陰性の判定を行う。   After removing the nozzle sealing cap 38 from the nozzle tube 30, several drops of the mixed solution W of the wiping solution S and the specimen extraction reagent T are dropped on the sample adding portion 46 of the assay strip 45. Thereafter, the specimen is detected using the assay strip 45, and positive / negative determination is performed.

本件発明の実施の形態を示す縦断面図である。It is a longitudinal cross-sectional view which shows embodiment of this invention. 容器本体に綿棒を挿入した時の状態を示す縦断面図である。It is a longitudinal cross-sectional view which shows a state when a cotton swab is inserted in the container main body. 検査時の状態を示す縦断面図である。It is a longitudinal cross-sectional view which shows the state at the time of a test | inspection.

符号の説明Explanation of symbols

1 容器本体
3 容器口部
10 蓋体
12 中栓
14 ヒンジ
16 外筒
17 頂壁
18 内筒
20 綿棒挿入口
25 指押開口用突起
30 ノズル筒
33 フイルタ
DESCRIPTION OF SYMBOLS 1 Container body 3 Container port part 10 Cover body 12 Inner plug 14 Hinge 16 Outer cylinder 17 Top wall 18 Inner cylinder 20 Cotton swab insertion opening 25 Finger pushing opening projection 30 Nozzle cylinder 33 Filter

Claims (7)

予め検体抽出試薬が収容された容器本体と、該容器本体の口部に装着される蓋体とからなる検体検出用抽出容器であって;
前記蓋体は、前記容器本体の口部を閉鎖する中栓と、該中栓にヒンジを介して連結されたノズル筒とを備えており、
前記中栓の頂壁には、前記ノズル筒を前記ヒンジを中心に回転させることにより露出し、ぬぐい液が付着した綿球が挿入される綿棒挿入口を当該頂壁に開口するための開口手段が設けられ、
前記ノズル筒の内側には、フイルタが挿着され、その外側には、ノズル封止キャップが被着されていることを特徴とする検体検出用抽出容器。
A sample detection extraction container comprising a container main body in which a sample extraction reagent is stored in advance, and a lid attached to the mouth of the container main body;
The lid includes an inner stopper that closes the mouth of the container body, and a nozzle cylinder connected to the inner stopper via a hinge,
An opening means for opening a cotton swab insertion opening into the top wall, which is exposed by rotating the nozzle cylinder about the hinge and into which a cotton ball with a wiping solution is inserted is inserted into the top wall of the inner plug. Is provided,
An extraction container for specimen detection, wherein a filter is inserted inside the nozzle cylinder, and a nozzle sealing cap is attached outside.
前記中栓は、容器口部の外周面に螺着される外筒と、該外筒に連続し、容器口部の内面に当接する内筒と、を備えており、
前記ノズル筒は、ヒンジが連結される中栓当接筒部と、該中栓当接筒部に連続し、フイルタが挿着されているノズル部とを備えていることを特徴とする請求項1記載の検体検出用抽出容器。
The inner plug includes an outer cylinder that is screwed to the outer peripheral surface of the container mouth portion, and an inner cylinder that is continuous with the outer cylinder and contacts the inner surface of the container mouth portion,
The said nozzle cylinder is provided with the inside stopper contact cylinder part to which a hinge is connected, and the nozzle part which is continued to this inside stopper contact cylinder part, and the filter is inserted. The extraction container for specimen detection according to 1.
前記開口手段が、開口用突起であることを特徴とする請求項1記載の検体検出用抽出容器。   2. The specimen detection extraction container according to claim 1, wherein the opening means is an opening protrusion. 前記中栓当接筒部の内側に、シールリングが設けられていることを特徴とする請求項2記載の検体検出用抽出容器。   The extraction container for sample detection according to claim 2, wherein a seal ring is provided inside the inner stopper abutting tube portion. 前記中栓の頂壁に、ノズル筒に係合する係止突起が立設されていることを特徴とする請求項1記載の検体検出用抽出容器。   2. The specimen detection extraction container according to claim 1, wherein a locking projection that engages with the nozzle cylinder is provided on the top wall of the inner plug. 前記容器本体は、可撓性を有することを特徴とする請求項1記載の検体検出用抽出容器。   2. The specimen detection extraction container according to claim 1, wherein the container body has flexibility. 前記容器本体は、透明、もしくは半透明であることを特徴とする請求項1、又は6記載の検体検出用抽出容器。 The extraction container for specimen detection according to claim 1 or 6, wherein the container body is transparent or translucent.
JP2005221964A 2005-07-29 2005-07-29 Sample detection extraction container Expired - Fee Related JP4697783B2 (en)

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JP4961029B2 (en) * 2010-05-31 2012-06-27 株式会社シン・コーポレイション Inspection kit
JP5713277B2 (en) * 2011-01-20 2015-05-07 凸版印刷株式会社 Reagent container and detection kit
JP7360957B2 (en) 2019-01-18 2023-10-13 ロート製薬株式会社 Sample extraction container and sample testing kit
CN111889002A (en) * 2020-08-25 2020-11-06 郑州金域临床检验中心有限公司 Test specimen pretreatment device and use method thereof
CN113604346B (en) * 2021-09-02 2023-11-17 浙江仅一医疗科技有限公司 Detection device containing reagent and method for detecting nucleic acid using detection device
CN113848323A (en) * 2021-10-30 2021-12-28 嘉兴康源科泰科技发展有限公司 Column pushing type sampling detection integrated rapid detection structure and application thereof

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JPH07260777A (en) * 1994-03-18 1995-10-13 Nissho Corp Specimen pickup tool
JPH1095450A (en) * 1996-09-19 1998-04-14 Mikasa Sangyo Kk Container and heat resistant cap for the container
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JP2003344232A (en) * 2002-03-18 2003-12-03 Elmex Ltd Wipe inspection kit, and wipe inspection method using the same

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