JP4549229B2 - Blood purification system - Google Patents

Description

  The present invention relates to a blood purification system having a plurality of types of blood circuits and a blood processing apparatus, and more particularly to a blood purification system in which the combination of blood circuits attached to a blood processing apparatus is changed corresponding to treatment.

  In addition to blood purification methods typified by general dialysis such as hemodialysis, blood filtration, and hemofiltration dialysis, in order to avoid adverse effects that can occur when these therapies are administered in a short time, especially for critically ill patients, Over time, the method of gradually returning to normal, that is, continuous blood purification therapy, has become widespread. In continuous blood purification therapy, in order to perform blood purification gradually over a long period of time, it is necessary to manage patient body fluid balance more strictly. Therefore, a highly accurate device is required. For example, Japanese Patent No. 3180309 (Patent Document 1), Japanese Patent Application Laid-Open No. 11-276578 (Patent Document 2) and Japanese Patent No. 3186518 (Patent Document 3) disclose continuous blood filtration that is a continuous blood purification therapy. Devices have been proposed for use in dialysis and continuous blood filtration.

  An example of an apparatus (hereinafter referred to as a blood purification system) embodying the description of these documents will be described with reference to FIGS.

  The blood purification system 10 corresponds to FIG. 1 of Patent Document 1 and FIG. 2 of Patent Document 2, and as shown in FIGS. 7, 8, and 9, a blood processing apparatus 20 that controls the operation of the system. In addition, the blood purifier 40 and five types of blood circuits 31 to 35 are provided. These blood circuits are configured by combining various components such as a connector member 37 and a chamber 38 with a tube 36 as a main component.

  The blood removal circuit 31 is a circuit for taking out blood from a patient and introducing it into the blood purifier 40. As shown in FIG. 8, an outline of the blood pump tube 41 is an essential component of the blood purifier entrance. In addition to a chamber 38a used for pressure measurement, a negative pressure sensor (pillow sensor) 42 for monitoring poor blood removal from a patient, a connector connected to a blood access catheter, an anticoagulant is introduced to prevent blood coagulation. It has a heparin line, a mixed injection button for adding chemicals if necessary.

  The blood return circuit 32 is a circuit that returns the blood purified by the blood purifier to the patient. In addition to the chamber 38b for measuring the pressure at the outlet of the purifier and injecting a replenisher, a connector, if necessary, mixed injection It has buttons and so on.

  The filtrate circuit 33 is a discharge line connected to a port communicating with the blood purifier 40 in order to discharge wastes, excess water, and the like that are filtered by the blood purifier. In addition to a connector for connection with a blood purifier, a filtration pressure measuring chamber 38c, a filtrate pump tube, a filtrate measuring chamber 38d and the like are usually provided.

  The dialysate circuit 34 is a supply line connected to a port communicating with the blood purifier 40 in order to supply a chemical solution such as dialysate to the blood purifier. In addition to a connector for connection to the blood purifier, the blood pressure sensor has a dialysate pump tube for supplying dialysate, a measuring chamber 38e used for accurately supplying dialysate, and the like. In this example, two pieces (34a, 34b) are provided as shown in FIG. 9 in order to facilitate priming (pretreatment) before treatment and to attach a warmer sheet for dialysate warming as needed. ) And is connected to the right end connector on the 34b side at the connection portion 45 on the 34a side after priming.

  The replacement fluid circuit 35 is a circuit for injecting a replenisher solution such as a chemical solution, nutrient, electrolyte, water, fresh plasma into the blood. Each of the circuits described above is connected to the blood purifier, while the replacement fluid circuit is connected in the middle of the blood return circuit. The replacement fluid circuit normally includes a connector for connecting to the chamber 38b in the blood return circuit 32, a replacement fluid pump tube, and a replacement fluid metering chamber 38f used for supplying the replacement fluid with high accuracy. Also, in order to facilitate priming (pretreatment) and to attach a warmer sheet for heating the replenisher as necessary, the replenisher is mixed in the chamber 38b in the blood return circuit 32, It is preferable that the replenisher can be divided into two parts in the middle of the flow path. In this example, the replacement fluid line connection portion 46 in the replacement fluid circuit 35 is divided so that it can be connected to the connector 47 in the blood return circuit 32. The “post-replacement dilution line” from the connector 47 in the blood return circuit 32 to the chamber 38b may be regarded as a part of the replacement fluid circuit.

  The blood processing apparatus 20 has a vertically long rectangular parallelepiped processing apparatus main body 21, and various components such as a pump unit 22 and a bubble sensor 23 are arranged on the front and right side surfaces thereof. Blood circuits 31 to 35 are arranged at positions of various components of the blood processing apparatus 20, and the blood circuits 31 to 35 and various components of the blood processing apparatus individually execute various processing operations. For example, the pump unit 22 has a roller pump that is a tube pump and a pump platen, and sequentially presses the outer peripheral surface of each pump tube in the longitudinal direction to pump the liquid inside the tube.

  In this blood purification system 10, when performing continuous blood filtration dialysis therapy, all of the blood circuits 31 to 35 are used, and they need to be connected to a predetermined portion of the connection port of the blood purification device 40 and the blood circuits. The parts are connected to form the entire circuit (see FIG. 11). 11 corresponds to FIG. 1 of Patent Document 1 and FIG. 2 of Patent Document 2. Also in Patent Document 2, the continuous blood filtration dialysis system shown in FIG. 2 is excluded from the system for continuous blood filtration dialysis shown in FIG. The circuit used depends on the treatment mode. At this time, the blood purifier is also changed to an appropriate one. Therefore, the blood purification system 10 can also be applied to other treatment modes by changing the combination of the blood circuits 31 to 35. For example, as shown in FIG. 10, when blood adsorption is performed, a blood removal circuit 31 and a blood return circuit 32 that are minimum units are connected to a blood purifier 40 and attached to the blood processing apparatus 20.

  Similarly, when performing ultrafiltration, the blood removal circuit 31, the blood return circuit 32, and the filtrate circuit 33 are attached, and when performing continuous hemodialysis, the blood removal circuit 31, the blood return circuit 32, and the filtrate circuit. 33 and dialysate circuit 34 are attached. When performing continuous blood filtration, a blood removal circuit 31, a blood return circuit 32, a filtrate circuit 33, and a replacement fluid circuit 35 are attached. As shown in FIG. 11, blood removal is performed when continuous blood filtration dialysis is performed. A circuit 31, a blood return circuit 32, a filtrate circuit 33, a dialysate circuit 34, and a replacement fluid circuit 35 are attached.

  However, in order to perform one therapy selected from a plurality of types of blood purification methods, an appropriate one is selected from a plurality of types of blood circuits 31 to 35 as shown in FIG. It is necessary to manually arrange the device 20 on the front and side surfaces. In the blood processing apparatus system 10, the circuit is color-coded on the mounting surface of the blood processing apparatus 20 so that there is no misplacement. However, the work is complicated, and an unskilled worker cannot install the circuit. There is also a possibility. Even if a mounting mistake can be detected before the start of treatment, it is extremely wasteful.

  On the other hand, for each blood purification therapy such as blood adsorption or ultrafiltration, all blood circuit groups necessary for the therapy are fixedly attached to a rigid unit, and the blood is made detachable from the blood processing apparatus. There exists a purification system (for example, Unexamined-Japanese-Patent No. 5-317418 (patent document 4)).

  In such a blood purification system, if one hard unit corresponding to a desired treatment is attached to the blood processing apparatus, the treatment corresponding to the hard unit can be executed. However, since the hard unit is formed for each treatment, the hard unit is enlarged and not easily stocked or handled.

In addition, in the blood purification system, before starting blood purification therapy, the so-called blood circuit is replaced with physiological saline to which an anticoagulant is added so that air does not remain in the flow path of blood and each liquid. Priming needs to be completed. In the apparatus shown in FIGS. 7 to 12, priming processing can be performed in parallel for each of a plurality of blood circuits, or at least two circuits can be partially performed simultaneously. Therefore, the priming cannot be completed quickly, and the start of treatment is delayed.
Japanese Patent No. 3180309 Japanese Patent Laid-Open No. 11-276578 Japanese Patent No. 3186518 JP-A-5-317418

  The present invention has been made in view of the above-described problems. The blood circuit can be easily attached to and detached from the blood processing apparatus, yet the blood circuit is easily stocked and handled, and treatment can be started quickly. An object of the present invention is to provide a blood purification system that can reduce human medical errors.

The present invention comprises (a) a blood purifier for purifying blood and (b) connected to this blood purifier or a different blood circuit in order to purify the blood derived from the patient and return it to the patient. A blood purification circuit comprising: a blood circuit for transporting at least a liquid selected from blood, a chemical liquid, a waste liquid and a mixture thereof; and (c) a blood processing apparatus having a pump unit so that the liquid can be transported by the blood circuit. A system,
Different blood circuits are fixed to different base members, and have a plurality of circuit units that are detachably attached to the blood processing apparatus ,
It said blood processing equipment further the plurality of circuit units of the base member detachably held to the holding mechanism, a plurality of circuit processing means to function each blood circuit provided in the mounted circuit unit, the circuit unit Corresponding to the combination of the processing storage means for storing the correspondence between the combination and the operation mode, the detachable sensor for detecting the circuit unit attached to the blood processing apparatus, and the combination of the circuit unit detected by the detachable sensor Search means for searching for the operation mode, and drive control means for operating only the specific circuit processing means corresponding to the searched operation mode,
A blood purification system capable of executing only a treatment mode corresponding to an operation mode permitted by a combination of mounted circuit units .

  The plurality of circuit units include a blood removal circuit unit including a blood removal circuit for extracting blood from a patient and introducing the blood into the blood purifier, and a return for returning the blood purified by the blood purifier to the patient. A blood return circuit unit having a blood circuit, a filtrate circuit unit having a filtrate circuit for discharging the filtrate filtered by the blood purifier, and a dialysate circuit for supplying a drug solution to the blood purifier It is preferably selected from the group consisting of a dialysate circuit unit and a replacement fluid circuit unit having a replacement fluid circuit for injecting a replenisher into the blood in the blood return circuit.

The blood purifier preferably performs a process selected from a blood filtration process and a blood adsorption process .

  In the present application, various means may be formed so as to realize the function. For example, dedicated hardware that exhibits a predetermined function, a computer device that is provided with a predetermined function by a computer program, a computer The program can be realized as a predetermined function realized by the computer apparatus, a combination thereof, or the like.

  In addition, the components of the present invention do not necessarily have to be individually independent, and a plurality of components are formed as one member, and one component has a plurality of members. It is also possible that a certain component is a part of another component, a part of a certain component overlaps a part of another component, and the like.

  In the blood purification system of the present invention, the blood circuits for performing individual operations are provided as circuit units fixed to the base member, so that the individual blood circuits can be easily attached to the blood processing apparatus. As in the prior art, the labor of manually mounting each member of the blood circuit is reduced, and no mounting error occurs. Since the treatment mode is determined by the combination of the mounted circuit units, an operation error performed on the display panel after the mounting is reduced, and a system in which an artificial medical error is extremely reduced can be provided.

  Furthermore, since it is unitized for each blood circuit, it has excellent flexibility and versatility, and because it is miniaturized, it is easy to stock and handle. In addition, the priming process can be performed in parallel on a plurality of blood circuits mounted on the blood processing apparatus, or partially in parallel on at least two or more blood circuits. Purification therapy can be started quickly.

[Configuration of the embodiment]
An embodiment of the present invention will be described below with reference to FIGS. However, the same parts as those of the conventional example described above with respect to the present embodiment are denoted by the same names and symbols, and detailed description thereof is omitted.

  The blood purification system 1000 of this embodiment has a blood purifier (not shown), one blood processing apparatus 100, and five types of blood circuits, like the blood purification system 10 of one conventional example. The blood purifier is preferably composed of a hollow fiber membrane module or the like as in the prior art, and an appropriate one is used according to the selected treatment mode.

  In the circuit units 201 to 205 used in the blood purification system 1000 of this embodiment, each blood circuit is fixed to a hard base member 211. The blood circuit units 201 to 205 are a blood removal circuit unit 201, a blood return circuit unit 202, a filtrate circuit unit 203, a dialysate circuit unit 204, and a replacement fluid circuit unit 205, respectively.

  More specifically, the base member 211 of the circuit units 201 to 205 is formed of a transparent resin in a box shape that is flat in the front-rear direction and opened at the rear surface, and each component of the blood circuit is disposed therein. ing. On the other hand, the blood processing apparatus 100 has, for example, a rectangular parallelepiped processing apparatus main body 101, and a unit selected from five types of circuit units 201 to 205 is mounted on the front surface of the processing apparatus main body 101.

  The blood removal circuit unit includes a blood removal circuit. The blood removal circuit is a circuit that constitutes a path for introducing blood derived from a patient into the blood purifier in order to introduce the patient's blood into the blood purifier. The circuit is mainly composed of a tube and, if necessary, has a chamber (a liquid reservoir), a sensor, a branch line, and the like. Specifically, in order to send blood in cooperation with the pump unit provided in the blood processing apparatus, a part of the circuit is provided with a blood pump tube, and, if necessary, the blood purifier inlet as in the prior art. A chamber used for pressure measurement, negative pressure sensor (pillow sensor), branch line (heparin line) for introducing an anticoagulant, connector, mixed injection button for adding a chemical if necessary it can. The connector portion can be changed as necessary to facilitate one-touch mounting. For example, the connection part with the blood access catheter may be the same as the conventional one, or may be connected via an extension adapter tube. The blood purifier may be connected directly to the inlet port of the blood purifier as in the prior art, or may be connected to an extension adapter tube drawn from the blood purifier inlet. .

  The blood return circuit unit includes a blood return circuit. The blood return circuit is a circuit that configures a path between blood return devices (such as a blood return catheter) for returning blood from the blood purifier outlet to the patient in order to return the blood purified by the blood purifier to the patient. It is. The general configuration of the circuit is the same as that of the blood removal circuit. Specifically, in addition to the tube used as a route, in addition to the chamber and connector for pressure measurement and replenisher injection on the outlet side of the purifier, a mixed injection button as necessary Etc. can be provided. As for the connector portion, an extension adapter tube may be used as in the blood removal circuit.

  The filtrate circuit unit includes a filtrate circuit. The filtrate circuit is a path for transferring the liquid discharged from the blood purifier in order to discharge the filtrate filtered by the blood purifier. The general configuration of the circuit is the same as that of the blood removal circuit. In detail, in addition to the connector for connecting directly to the port connected to the outside of the filtration membrane of the blood purifier or through an extension adapter tube, etc. It has a pressure measurement chamber, a filtrate pump tube, a filtrate measurement chamber, and the like.

  The dialysate circuit unit includes a dialysate circuit. The dialysate circuit is a path that connects a port communicating with the blood purifier from a chemical liquid (dialysate) container (or a chemical liquid introduction unit) in order to supply the chemical liquid to the blood purifier. The general configuration of the circuit is the same as that of the blood removal circuit, and more specifically, in order to supply dialysate in addition to a connector for connecting to a port communicating with the blood purifier directly or through an extension adapter tube or the like. It has a dialysate pump tube, a dialysate metering chamber, a connecting part for connecting to a drug solution container directly or through an instrument, and the like. Like the conventional example, it may be fixed in a state of being divided into two parts for attaching a heat exchanger such as a warmer sheet, and may be connected after the priming process.

  The replacement fluid circuit unit includes a replacement fluid circuit. The replacement fluid circuit is a path that connects the replacement fluid container (or the replacement fluid introduction unit) to the blood return circuit in order to inject the replacement fluid into the blood in the blood return circuit. The general configuration of the circuit is the same as that of the blood removal circuit. Specifically, the circuit has a connection portion for connection in the middle of the blood return circuit. The place where the replenisher is injected is usually a chamber in the blood return circuit, a connector for connecting directly to this chamber or via an extension adapter tube, a replenisher pump tube, and a replenisher for accurately supplying the replenisher. A chamber for measuring fluid replacement is provided. In addition, the circuit can be divided into two before it is connected to the chamber in the blood return circuit for easy priming and for mounting a heat exchanger such as a warmer sheet for heating the replenisher. Is preferred.

  In each of the blood circuits described above, one-touch mounting can be facilitated, or an appropriate connector can be selected in consideration of the layout between the units, and if necessary, circuit extension and routing means such as an extension adapter tube can be provided. .

  Each member of each blood circuit is a known material such as polyvinyl chloride, polyethylene, ethylene vinyl acetate resin, polypropylene, polycarbonate, polyurethane, polystyrene, silicone resin, polymethyl methacrylate, tetrafluoroethylene resin, polyethylene terephthalate, Nylon resin, polysulfone, ABS (Acrylonitrile Butadiene Styrene) resin, polyacetal and the like can be appropriately selected and used. The pump tube portion in each circuit is formed of at least a flexible material, and materials such as soft polyvinyl chloride, silicone resin, polyurethane, polyethylene, and ethylene vinyl acetate resin can be used. Of the tube through which the liquid flows in the circuit path, the portion other than the pump tube may be formed of the same soft material as that of the pump tube, and polypropylene is used as long as no inconvenience occurs during the connection operation or priming operation. A relatively hard material, such as, may be used.

  The chamber, connector and the like are preferably appropriately selected from hard materials, such as polypropylene, polycarbonate, polystyrene, polymethyl methacrylate, tetrafluoroethylene resin, polyethylene terephthalate, nylon resin, polysulfone, ABS resin, polyvinyl chloride and polyacetal. Etc. can be used.

  The base member of the circuit unit can be used if it is hard enough to hold at least each circuit composed of a tube, a chamber, a connector, and the like, and a material that can be visually recognized through the base member is preferable. For example, polyvinyl chloride, polyethylene, ethylene vinyl acetate resin, polypropylene, polycarbonate, polyurethane, polystyrene, silicone resin, polymethyl methacrylate, tetrafluoroethylene resin, polyethylene terephthalate, nylon resin, polysulfone, ABS resin, polyacetal, etc. Can do. More preferred are polypropylene, polycarbonate, polyurethane, polystyrene, polymethyl methacrylate, tetrafluoroethylene resin, polyethylene terephthalate, nylon resin, polysulfone, ABS resin, polyacetal, etc., and particularly preferred are polypropylene, polycarbonate, polystyrene, polymethyl methacrylate. Polyethylene terephthalate, nylon resin, polysulfone, ABS resin and the like.

  Next, the shape of the circuit unit will be described.

  In this embodiment, the base member 211 of the circuit units 201 to 205 is formed in a box shape. For example, each blood circuit including a tube or the like on the rear surface may be disposed with the base member as a flat plate. Similarly, a blood circuit including a tube or the like may be arranged on the front surface of the base member. In that case, for example, a pump or the like is formed by forming a through-hole through which the pump unit 110 or the like is inserted at a main part of the base member. Can be fitted. Furthermore, a form in which a blood circuit including a tube or the like is enclosed between a pair of sheet-like base members in which through holes are formed at important points is also possible.

  Any method may be used for fixing the blood circuit to the base member, but among the members of the blood circuit, those made of a hard material such as a chamber are preferably held and fixed to the base member. . In addition to the adhesive, adhesive tape, and screwing, the fixing may be performed by using a member that grips the chamber or the tube as an auxiliary. You may form a base member with a holding part by well-known shaping | molding methods, such as injection molding and press molding.

  Further, in this embodiment, the base member 211 is formed of a transparent resin. However, for example, the base member may be opaque, and transparent resin or a through hole is provided at a point of such an opaque base member. It is also possible that the window part which it has is formed.

  On the other hand, in the blood processing apparatus 100, circuit processing means such as the pump unit 110 and the bubble sensor 23 are arranged at various locations on the front surface of the processing apparatus main body 101, and the circuit processing means is connected to the blood circuits in the circuit units 201 to 205. Processing operations such as pump drive and bubble detection are executed.

  The blood processing apparatus 100 is provided with concave holes 102 as holding mechanisms at various locations on the front surface of the processing apparatus main body 101 so that the circuit units 201 to 205 can be mounted, while the base members of the circuit units 201 to 205 are provided. A convex portion (not shown) that engages with the concave hole 102 is formed on the rear surface of 211. Such a holding mechanism may have any structure as long as the blood circuit can be attached to and detached from the blood processing apparatus by so-called one-touch.

  In the blood purification system 1000 of this embodiment, as shown in FIG. 2, the rectangular front surface of the blood processing apparatus 100 may be filled without a gap. In this figure, the filtrate circuit unit 203 is formed in a rectangular shape. In addition, the other circuit units 201, 202, 204, and 205 are formed in an L shape. The positions of the five types of circuit units 201 to 205 that are attached to the front surface of the blood processing apparatus 100 are individually defined, so that only the dedicated positions are detachable, such as the outer shape and the position of the convex portion. Has been devised. Such a configuration allows a blood purifier (not shown) to be mounted inside blood processing apparatus 100 or at least one of these circuit units, such as a blood removal circuit unit or a blood return circuit unit. However, when the blood purifier is mounted on the front surface of the blood processing apparatus, a space is provided between the circuit units for mounting the blood purifier or the base member. It is preferable to open a necessary part of the side surface of the.

  In addition, as a method for preventing erroneous mounting, it is achieved by defining the shape in FIG. 2, but even if each unit has the same shape, for example, by changing the arrangement of the holding mechanism on the blood processing apparatus side. A dedicated position can be defined for each unit.

  In this embodiment, the circuit units are two-dimensionally arranged on the front surface of the blood processing apparatus, but a plurality of blood circuits may be attached to the blood processing apparatus in a structure that intersects three-dimensionally. In such a structure, the order in which the blood circuits are attached is regulated. For example, by using this, it is possible to prevent a plurality of blood circuits from being attached in an inappropriate order.

  In the blood purification system 1000 of this embodiment, when a plurality of circuit units 201 to 205 are attached to the blood processing apparatus 100, each blood circuit, each port of the blood purifier, and necessary portions between the circuit units are connected.

  FIG. 2 schematically shows an example in which connector members 212 to which internal tubes and the like are connected are arranged on the upper, lower, left, and right surfaces of the base member 211 of the circuit units 201 to 205. Since the number of connector members appearing on these side surfaces is appropriately changed, the number shown in FIG. 2 is not necessarily required. In particular, the connector member 212 is preferably fixed so that it can be connected to the blood treatment apparatus in the front-rear direction, if necessary. When connecting manually, the connector member may be fixed to the base member. Can be either.

  In this embodiment, when the circuit units 201 to 205 are mounted on the front surface of the blood processing apparatus 100, the connection is made mechanically by the connector member 212 or the like fixed in the side surface or the front-rear direction. It is also possible for the blood processing apparatus 100 to electrically connect the connector members 212 of the units 201 to 205, and in particular in a plurality of blood circuits arranged via gaps, the connector members are manually connected. It is also possible to do so.

  The connector member 212 located outside with the circuit units 201 to 205 mounted on the blood processing apparatus 100 is preferably used for external access such as connection to a blood access catheter, connection to a dialysate container, and the like. . Therefore, when the circuit units 201 to 205 are arranged without a gap, it is preferable that the arrangement is determined in consideration of access to the outside.

  Moreover, in the blood processing apparatus 100 of this embodiment, the pump unit 110 includes a roller pump 111 and a pump platen 112 that are tube pumps, as shown in FIG. The roller pump 111 has a cylindrical member in which a plurality of roller members are arranged on the outer peripheral surface, and is rotatably supported.

  The pump platen 112 is formed in an arc shape and presses the pump tube 113 such as the blood pump tube 41 against the roller pump 111. However, in the blood processing apparatus 100 of this embodiment, the pump platen 112 and the roller pump 111 can be brought close to each other and opened by a pump opening / closing mechanism (not shown) having a guide rail, a crank mechanism, and the like. Therefore, as shown in FIGS. 3 (a) and 3 (b), the pump unit 110 is in an open state in which the roller pump 111 and the pump platen 112 are separated from each other and the pump tube 113 can be attached and detached. As shown in c), it is possible to switch between a closed state in which the pump platen 112 presses the soft tube 36 against the roller pump 111.

  In this embodiment, the pump unit 110 is electrically opened and closed. In this case, when the circuit units 201 to 205 are removed from the blood processing apparatus 100, for example, the pump unit 110 needs to be opened manually. No electrical mechanism or control is required.

  Next, the internal processing of the blood processing apparatus of this embodiment will be described. As shown in FIG. 4, the blood processing apparatus 100 of the present embodiment includes a blood removal mechanism 121, using circuit processing means such as a pump unit and a pressure monitor prepared for each of the five types of circuit units 201 to 205 as described above. A blood return mechanism 122, a filtrate mechanism 123, a dialysis mechanism 124, and a replacement fluid mechanism 125 are configured.

  In addition, the detachable sensors 131 to 135 and the lock mechanisms 141 to 145 are individually arranged inside the recessed holes 102 for the five types of circuit units 201 to 205 of the processing apparatus main body 101. The detachable sensors 131 to 135 include, for example, press switches arranged inside the recessed hole 102, and individually detect mounting of five types of circuit units 201 to 205 as unit detection means.

  The lock mechanisms 141 to 145 are formed to be openable and closable by a solenoid, for example, and fixedly hold the five types of circuit units 201 to 205 attached to the processing apparatus main body 101. The attachment / detachment sensors 131 to 135 and the lock mechanisms 141 to 145 may have any structure as long as their functions can be realized, and the blood treatment apparatus 100 may not include the attachment / detachment sensors 131 to 135 and the lock mechanisms 141 to 145. is there.

  Furthermore, the blood processing apparatus 100 of this embodiment also has an operation panel 151 and a display panel 152, and the above-described various mechanisms 121 to 125, the detachable sensors 131 to 135, and the lock mechanisms 141 to 145 are computer units. 150.

  The blood processing apparatus 100 according to this embodiment includes a display panel 152 and various mechanisms 121 corresponding to a computer program in which the computer unit 150 is mounted, input data of the operation panel 151, detection data of the attachment / detachment sensors 131 to 135, and the like. ˜125, lock mechanisms 141˜145, etc., by integrated control, as shown in FIG. 5, circuit display means 161, process storage means 162, process search means 163, process display means 164, drive control means 165, etc. The various means are logically included.

  The circuit display means 161 corresponds to a function of the computer unit 150 generating display data on the display panel 152 corresponding to the detection data of the attachment / detachment sensors 131 to 135, and the circuit unit whose attachment is detected by the attachment / detachment sensors 131 to 135. 201 to 205 are displayed and output on the display panel 152.

  The processing storage unit 162 corresponds to a database constructed in an internal memory (not shown) of the computer unit 150, and stores correspondences between a plurality of types of combinations of the circuit units 201 to 205 and a plurality of types of operation modes. is doing.

  This correspondence is as shown in the following table, for example.

この表で、最初の組み合わせを除いて、回路ユニットの１つの組み合わせに対して、２つの動作モードおよび２つの治療モードが対応している。即ち、治療モードは、回路ユニットの組み合わせ、血液浄化器の種類等にも依存する。従って、血液浄化器のデータ等により上記表が参照され、表中のａ、ｂのどちらを選択するかが定まるか、またはどちらかを人為的に選択することになる。

In this table, except for the first combination, two operation modes and two treatment modes correspond to one combination of circuit units. That is, the treatment mode also depends on the combination of circuit units, the type of blood purifier, and the like. Therefore, the above table is referred to based on blood purifier data or the like, and it is determined which one of “a” and “b” in the table is selected, or which one is selected artificially.

  The process search unit 163 corresponds to a function of the computer unit 150 executing predetermined data processing corresponding to the detection data of the attachment / detachment sensors 131 to 135, and corresponds to a combination of the circuit units 201 to 205 in which the attachment is detected. Search the operation mode. The processing display unit 164 corresponds to a function of the computer unit 150 generating display data on the display panel 152 by data processing, and displays and displays the treatment in the searched operation mode on the display panel 152. The drive control means 165 corresponds to the function of the computer unit 150 controlling the operation of the pump unit 110 in response to the detection data of the attachment / detachment sensors 131 to 135, and only the circuit processing means corresponding to the searched operation mode can be operated. To do.

  As described above, according to the present invention, the operation mode is determined by the combination of the mounted circuit units, and the treatment mode of the blood purification therapy corresponding to the operation mode is determined. Therefore, human error is extremely reduced.

[Operation of the embodiment]
In the blood purification system 1000 according to the present embodiment having the above-described configuration, the five types of circuit units 201 to 205 are combined in a desired combination in one blood processing apparatus 100 as in the blood purification system 10 of one conventional example. It is possible to carry out various treatments such as blood adsorption by attaching the device.

  However, unlike the blood purification system 10 of the conventional example, the blood purification system 1000 according to the present embodiment is formed as circuit units 201 to 205, and the circuit units 201 to 205 are attached to the blood processing apparatus 100. There is no need to manually place the soft tube 36.

  More specifically, the blood processing apparatus 100 according to the present embodiment disables circuit processing means such as the pump unit 110 in the initial state in which the circuit units 201 to 205 are not mounted as shown in FIG. In step S1), the circuit processing means such as the pump unit 110 does not operate in a state where the circuit units 201 to 205 are not mounted.

  Furthermore, since the pump unit 110 and the lock mechanisms 141 to 145 are open in the initial state (step S2), the circuit units 201 to 205 are freely attached to the blood processing apparatus 100. Therefore, when performing various treatments such as blood adsorption, an operator (not shown) selects the corresponding circuit units 201 to 205 and attaches them to the blood processing apparatus 100.

  Then, in this blood processing apparatus 100, the attached circuit units 201 to 205 are detected by the attachment / detachment sensors 131 to 135 (step S3), and the detected circuit units 201 to 205 are displayed and output by the display panel 152 (step S3). Step S4). Furthermore, an operation mode corresponding to the detected circuit units 201 to 205 is searched (step S5), and a treatment mode is displayed and output on the display panel 152 as the searched operation mode (steps S6 and S7). If no operation mode is found, an error message is displayed and output (steps S6 and S8).

  As described above, the treatment mode is determined not only by the combination of the circuit units but also by the selection of the blood purifier, and is displayed when there are a plurality of treatment modes for a specific combination of two circuit units. Selected from multiple treatment modes, or when blood purifier data is acquired in advance, only the treatment mode determined by the combination with the blood purifier is automatically selected and displayed. Become.

When blood treatment apparatus 100 enters a state in which treatment for blood purification therapy can be performed as described above, pump unit 110 and lock mechanisms 141 to 145 corresponding to the retrieved treatment mode are closed (step S9). Therefore, the circuit units 201 to 205 attached to the blood processing apparatus 100 are fixed, and the pump tube 113 is appropriately loaded into the pump unit 110 as shown in FIG. In this state, it becomes a standby state (step S10).
In the blood purification system 1000 of the present embodiment, the priming process is preferably performed on the plurality of circuit units 201 attached to the blood processing apparatus 100 as described above, preferably in parallel or on at least two or more circuits. Partially executed at the same time.

  When a treatment that can be performed as described above has been detected and priming has been completed, when operation start is input to the operation panel 151 (step S11), circuit processing means such as the pump unit 110 corresponding to the treatment mode Only by being driven (step S12), the treatment mode is executed.

  Then, the blood processing apparatus 100 that performs the treatment in this way detects the end of work due to the occurrence of a predetermined state or the like (step S13), and when the end of work is input to the operation panel 151 (step S14), the pump Since the circuit processing means such as the unit 110 is stopped (step S15), the treatment is completed. The blood processing apparatus 100 opens the pump unit 110 and the lock mechanisms 141 to 145 (step S16), so that the operator can easily remove the circuit units 201 to 205 from the blood processing apparatus 100 after the treatment.

  As described above, in the present invention, since the treatment mode is determined by the mounted circuit unit, it is possible to reduce the input operation required after the mounting. Therefore, human error is significantly reduced.

It is a typical perspective view which shows the use condition of the blood purification system of one Embodiment of this invention. (a) is a perspective view which shows the external appearance of a blood processing apparatus, (b) is a perspective view which shows the external appearance of a blood circuit. It is a front view which shows a pump unit. It is a block diagram which shows the physical structure of a blood purification system. It is a schematic diagram which shows the logical structure of a blood purification system. It is a flowchart which shows the processing operation of a blood processing apparatus. It is a perspective view which shows the blood processing apparatus of one prior art example. It is a schematic diagram which shows the blood circuit of a blood purification system. It is a schematic diagram which shows the blood circuit of a blood purification system. It is a schematic diagram which shows an example of the use condition of a blood purification system. It is a schematic diagram which shows an example of the use condition of a blood purification system.

Explanation of symbols

DESCRIPTION OF SYMBOLS 100 Blood processing apparatus 110 Pump unit which is a part of circuit processing means 111 Roller pump which is a tube pump 112 Pump platen 113 Pump tube 161 Circuit display means 162 Process storage means 163 Process search means 164 Process display means 165 Drive control means 201 Detaching Blood circuit unit 202 Blood return circuit unit 203 Filtrate circuit unit 204 Dialysate circuit unit 205 Fluid replacement circuit unit 1000 Blood purification system

Claims (4)

In order to purify the blood derived from the patient and return it to the patient, (a) a blood purifier that performs blood purification processing , and (b) at least blood connected to the blood purifier or a different blood circuit, A blood purification system comprising a blood circuit for transferring a liquid selected from a chemical liquid, a waste liquid and a mixture thereof, and (c) a blood processing apparatus having a pump unit so that the liquid can be transferred by the blood circuit. ,
Different blood circuits are fixed to different base members, and have a plurality of circuit units that are detachably attached to the blood processing apparatus ,
It said blood processing equipment further the plurality of circuit units of the base member detachably held to the holding mechanism, a plurality of circuit processing means to function each blood circuit provided in the mounted circuit unit, the circuit unit Corresponding to the combination of the processing storage means for storing the correspondence between the combination and the operation mode, the detachable sensor for detecting the circuit unit attached to the blood processing apparatus, and the combination of the circuit unit detected by the detachable sensor Search means for searching for the operation mode, and drive control means for operating only the specific circuit processing means corresponding to the searched operation mode,
A blood purification system capable of executing only a treatment mode corresponding to an operation mode permitted by a combination of mounted circuit units . The plurality of circuit units are:
A blood removal circuit unit comprising a blood removal circuit for deriving blood from a patient and introducing it into the blood purifier,
A blood return circuit unit comprising a blood return circuit for returning the blood purified by the blood purifier to the patient;
A filtrate circuit unit comprising a filtrate circuit for discharging waste liquid filtered by the blood purifier,
Selected from the group consisting of a dialysate circuit unit having a dialysate circuit for supplying medicinal solution to the blood purifier, and a replacement fluid circuit unit having a replacement fluid circuit for injecting replenisher into the blood in the blood return circuit The blood purification system according to claim 1. The blood purification system according to claim 1 or 2, wherein the blood purifier performs a process selected from a blood filtration process and a blood adsorption process . For the blood treatment device,
When the blood removal circuit unit and the blood return circuit unit are attached, only blood adsorption can be performed as a treatment mode ,
When the blood removal circuit unit, the blood return circuit unit and the filtrate circuit unit are attached, only ultrafiltration or plasma adsorption can be performed as a treatment mode ,
When the blood removal circuit, the blood return circuit, the filtrate circuit and the dialysate circuit are attached, only hemodialysis or plasma exchange can be performed as a treatment mode ,
When the blood removal circuit, the blood return circuit, the filtrate circuit and the replacement fluid circuit are attached, only blood filtration or plasma exchange can be performed as a treatment mode ,
When the blood removal circuit, the blood return circuit, the filtrate circuit, the dialysate circuit, and the replacement fluid circuit are attached, only blood filtration dialysis or plasma exchange can be performed as a treatment mode.
Blood purification system according to any one of claims 1 to 3, wherein the.

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