JP4182005B2 - Biological component measuring device - Google Patents

Description

  The present invention relates to a measuring apparatus and a measuring method for measuring a specific biological component in a biological sample collected by puncturing a living body. In particular, the present invention relates to a biological component measurement method and apparatus for storing, processing and / or displaying a sample collection site and a measurement value in association with each other.

  So far, various types of biosensors utilizing specific catalytic action of enzymes have been developed. In particular, glucose sensors that quantify glucose are widely used for blood glucose level (glucose contained in blood) in clinical tests. Hereinafter, a glucose sensor which is an example of a biosensor will be described.

  As an electrochemical method for quantitative determination of glucose, a method using glucose oxidase (EC 1.1.3.4: hereinafter abbreviated as GOD), which is an enzyme, and an oxygen electrode or a hydrogen peroxide electrode is generally known. (For example, see Non-Patent Document 1).

  This method makes it possible to accurately quantify glucose in a biological sample by utilizing the specificity of the enzyme reaction. However, the measurement result is greatly affected by the oxygen concentration contained in the sample. In the absence of oxygen, measurement was impossible.

  Therefore, a new type of glucose sensor has been developed that does not use oxygen as an electron carrier but uses an organic compound or metal complex such as potassium ferricyanide, a ferrocene derivative, or a quinone derivative as an electron carrier.

  Thus, by using an organic compound or a metal complex as an electron carrier, glucose can be accurately quantified without being affected by the oxygen concentration in the biological sample.

  Furthermore, in this case, since the reagent layer containing the enzyme and the electron carrier can be integrated with the electrode system in a state close to a dry state, it becomes possible to make a disposable glucose sensor based on this technology. It has become widespread.

  In a disposable glucose sensor, glucose can be easily measured with a measuring device simply by introducing a biological sample into a sensor detachably connected to the measuring device (see, for example, Patent Document 1).

  With the widespread use of glucose sensors as described above, it has become possible for diabetic patients to easily measure blood glucose levels at home. As the procedure, the following methods are common.

  First, the collection site is punctured with a needle attached to the puncture device. Next, a biological sample (here, blood) is squeezed out from the punctured site. Finally, the sensor previously mounted on the measuring device is brought close to the punctured site, the biological sample supply port of the sensor is brought into contact with the squeezed blood, and the blood is supplied into the sample tank of the sensor. When the biosensor detects glucose in the blood, glucose contained in the blood can be quantified. In the measurement using the glucose sensor as described above, the substrate concentration in the biological sample can be easily obtained with the amount of the biological sample on the order of several μl.

  In blood glucose measurement, conventionally, it has been common to puncture a fingertip and collect blood. However, in recent years, methods other than fingertips, such as collecting blood with a forearm and measuring blood glucose levels, are also used. It has become.

  This method has the advantage that no wound remains on the fingertip and the forearm has less pain points than the fingertip, resulting in less pain during measurement. The options are expanded.

  In recent years, in order to further simplify the measurement procedure, a product in which a puncture device and a glucose sensor measurement device are integrated has been sold. These products have the advantage that puncturing with a puncture device and measurement with a sensor can be performed with a single measuring device, and the measurement work process for diabetic patients is shortened.

As a conventional example of such an integrated measuring apparatus, there is a biosensor measuring instrument (Sofac (registered trademark) (Sof Tact ^™ )) for glucose measurement for the forearm currently available from Abbott. FIG. 11 is a schematic diagram thereof.

As shown, a measuring instrument 91 equipped with a biosensor for measuring glucose in blood and a puncture member for puncturing a living body includes a switch 93 for starting measurement and a display unit for displaying the obtained result. 92 and a contact surface 96 between the living body and the living body. The living body contact surface 96 includes a collection hole 97 for collecting blood exuded from the living body through which the puncture member protrudes. Since the biosensor having this configuration is designed so that the contact surface with the living body fits the forearm, it has been difficult to apply to collection from other parts, for example, collection from a fingertip.

On the other hand, when the blood glucose level changes drastically, such as immediately after a meal, even if the subject is the same, the glucose concentration measured by the biosensor differs depending on the blood collection site (fingertip, forearm, thigh, etc.) Has been reported (for example, Non-Patent Document 2). Therefore, depending on the elapsed time after a meal, even in the same subject, for example, a standard value based on a sample collected from a fingertip can be directly compared with an actual measurement value of a sample collected on the forearm. There was a problem that I couldn't.
Japanese Patent Laid-Open No. 03-202864 Shuichi Suzuki, “Biosensor”, Kodansha, January 1984, p. 100-101 John M. ELLISON, Diabetes Care vol25, No.6, 961-964, (2002)

  Thus, for example, in the case of blood glucose measurement, particularly when blood glucose fluctuations are large, such as after meals, blood glucose levels obtained by measurement may differ depending on the blood collection site, but conventional measurement devices use blood samples collected at different sites. (For example, the blood glucose level of the blood sample collected at the forearm and the blood glucose level of the blood sample collected at the fingertip) are not provided.

  Furthermore, the above-described conventional puncture device-integrated measuring apparatus has a problem that the biological sample collection site is limited to the forearm due to the structure of the contact surface to the collection site.

  In order to solve the above-described conventional problems, an object of the present invention is to provide a biological component measuring apparatus that does not limit a sample collection site, and that can perform both measurement with a fingertip and measurement with a fingertip.

  Furthermore, an object of the present invention is to provide a biological component measuring apparatus provided with a mechanism for storing, processing, and / or displaying a sampling site and a measurement value in association with each other in one apparatus. In particular, an object of the present invention is to provide a biological component measuring apparatus having a mechanism for correcting a blood glucose level of a sample collected at a site different from a fingertip according to the sample collection site and the sample collection time.

  The present invention also does not limit the sample collection site, in particular, it is possible to perform measurement at the fingertip and measurement outside the fingertip, and to store, process and / or display the sample collection site and the measurement result in association with each other. An object of the present invention is to provide a biological component measuring device in which a puncture device and a biosensor device are integrated.

  In addition, as described above, accurate monitoring and treatment of subjects can be performed even when blood glucose levels are monitored over time using a measuring device that can sample not only at the fingertips but also at parts other than the fingertips such as the forearm and thighs. An object of the present invention is to provide a biological component measuring apparatus capable of storing, processing and / or displaying a collection site and a measurement result in association with each other. In particular, an object of the present invention is to provide a biological component measuring apparatus having a mechanism for correcting blood glucose level of a sample collected at a site different from a fingertip according to the collection site and collection time.

  In order to solve the above-described conventional problems, in one aspect, the present invention provides a biological component measuring apparatus in which a puncture mechanism for puncturing a subject's skin and collecting sample blood is integrated with a biosensor measuring apparatus. Provide set. In this biological component measuring apparatus set, the puncture mechanism includes at least a puncture needle and a cap that is detachably fitted to the apparatus main body. The cap is a skin contact surface that comes into contact with the skin at the time of puncturing, and has an opening through which the puncture needle passes and punctures the skin, and fits the shape of the skin surface to be punctured A skin contact surface having a shape is provided. This biological component measuring device set includes a plurality of different caps according to sample collection sites so that a plurality of different sample collection sites can be selected.

  In a preferred embodiment of the biological component measuring apparatus set of the present invention, a cap for collecting a sample from a fingertip and a cap for collecting a sample from a forearm are included. In yet another embodiment, it further includes a cap for sampling from any site selected from the group consisting of palm, upper arm, thigh, and abdomen.

  In a further preferred embodiment of the biocomponent measurement device set of the present invention, the biosensor measurement device includes a biosensor mounting unit, a biocomponent information input unit for inputting measurement information from the biosensor, and a sample collection site A sample collection site input unit for inputting the information of, a storage unit, a calculation unit for calculating the substrate concentration in the sample blood based on information from the biological component information input unit, and the calculated substrate concentration And a display unit for displaying the information, wherein the input information of the sample collection site is recorded in the storage unit together with the calculated substrate concentration.

  In a preferred embodiment of the biological component measuring device set of the present invention, the biosensor is a glucose sensor.

  In a further preferred embodiment of the biological component measuring device set of the present invention, the input sample collection site information is displayed on the display unit together with the calculated substrate concentration.

  In another preferred embodiment of the biological component measuring device set of the present invention, the cap is a pair of electrics electrically connected to a constant resistance specific to the cap at least at a part of the fitting portion with the device main body. A contact is provided. Furthermore, the sample collection site input unit is a resistance measuring instrument and a second pair of electrical contacts electrically connected to the resistance measuring instrument, and when the cap is fitted to the apparatus main body, An electrical circuit is formed in contact with the pair of electrical contacts, and as a result, the resistance measuring device includes a second pair of electrical contacts that detect the constant resistance value. In this embodiment, the sample collection site is recognized based on the detected constant resistance value.

  In a further preferred embodiment of the biological component measurement device set of the present invention, the biosensor measurement device further includes a meal time input unit for inputting a meal time or an elapsed time after the meal, and the storage unit A correction table or correction formula for correcting the measurement value based on the elapsed time and the sample collection site is stored in advance, and the calculation unit calculates the meal time input to the meal time input unit or the elapsed time after the meal. The corrected substrate concentration is calculated with reference to the correction table or the correction formula stored in the storage unit based on the sample collection site input to the sample collection site input unit. .

  In another aspect, the present invention also provides a biological component measuring apparatus in which a puncturing mechanism for puncturing a subject's skin and collecting sample blood is integrated with a biosensor measuring apparatus. In this biological component measuring apparatus, the puncture mechanism includes at least a puncture needle and a cap that is detachably fitted to the apparatus main body. The cap includes a skin contact surface that comes into contact with the skin at the time of puncturing and has an opening for allowing the puncture needle to pass therethrough and puncture the skin. On the other hand, the biosensor measurement device includes a biosensor mounting unit, a biological component information input unit for inputting measurement information from the biosensor, and a sample collection site input unit for inputting information of the sample collection site A calculation unit for calculating the substrate concentration in the sample blood based on the information from the biological component information input unit, and a storage unit for recording the input sample collection site information together with the calculated substrate concentration And a display unit for displaying the calculated substrate concentration. The biological component measuring apparatus of the present invention according to this embodiment senses a contact state with the skin that can be electrically connected to the sample collection site input unit when the skin contact surface of the cap is fitted to the apparatus main body. At least two sensors, and the sample collection site input unit recognizes the sample collection site according to the number and / or combination of the sensors that sense the contact state.

  In a preferred embodiment of the biological component measurement apparatus according to another aspect of the present invention, the sample collection site input unit recognizes the sample collection site as a fingertip when only a part of the sensor senses contact with the skin. Features.

  In a further preferred embodiment of the biological component measurement apparatus according to another aspect of the present invention, the sample collection site input unit, when all the sensors sense contact with the skin, the sample collection site is a palm, forearm, upper arm, It is recognized as any part selected from the group consisting of a thigh and an abdomen.

  In another preferred embodiment of the biological component measurement device according to another aspect of the present invention, the biosensor measurement device further includes a meal time input unit for inputting a meal time or an elapsed time after the meal, and the storage unit is A correction table or a correction formula for correcting the measurement value based on the elapsed time after the meal and the sample collection site is stored in advance, and the calculation unit is the meal time input to the meal time input unit or after the meal The corrected substrate concentration is calculated with reference to the correction table or the correction formula stored in the storage unit based on the elapsed time of the sample and the sample collection site input to the sample collection site input unit It is characterized by.

In yet another aspect, the present invention provides a biosensor measurement device. The biosensor measurement device includes a biosensor mounting unit, a biological component information input unit for inputting measurement information from the biosensor, a sample collection site input unit for inputting information on a sample collection site, A calculation unit for calculating the substrate concentration in the sample blood based on information from the component information input unit, a storage unit for recording the input sample collection site information together with the calculated substrate concentration, It has a display unit for displaying the substrate concentration and a meal time input unit for inputting the meal time or the elapsed time after the meal , and the storage unit measures based on the elapsed time after the meal and the sample collection site A correction table or a correction formula for correcting the value is stored in advance, and the calculation unit calculates the meal time input to the meal time input unit or the elapsed time after the meal, and sampling Based on the sample collection site input to the position input unit, the corrected substrate concentration is calculated with reference to the correction table or the correction formula stored in the storage unit, and the storage unit further performs the correction. by storing the substrate concentration, the display unit, you and displaying the corrected substrate concentration.

  The biological component measuring apparatus of the present invention can interpret the measurement value more accurately by associating the collection site of the biological sample with the measurement result. Further, according to the present invention, it is possible to select a correction method for the measurement result by recognizing the collection site, and accurate measurement is possible.

  Hereinafter, embodiments of the present invention will be described in detail with reference to the drawings.

  In the following embodiments, a measuring apparatus and a measuring method used for quantifying blood glucose levels will be described as an example.

(Embodiment 1)
First, Embodiment 1 of the present invention will be described with reference to FIG. 1 and FIG.

  FIG. 1 is a schematic diagram showing the appearance of a puncture device integrated biological component measuring apparatus 1 of the present invention provided with a cap 18 adapted to collect a biological sample (here, blood) from a fingertip. FIG. 1A shows a state in which the cap 18 is fitted to the housing 11 that houses the apparatus main body and constitutes a part thereof, and FIG. 1B shows a state in which the cap 18 is removed.

  The biological component measuring apparatus 1 includes a housing 11 and a cap 18 made of a material such as plastic. The housing 11 is provided with a display unit 12 including a liquid crystal digital display for displaying a measurement value measured by the biosensor 69, and a switch 13 for starting measurement.

  As shown in FIG. 1B, the housing 11 includes a gasket 14 or other sealing mechanism for sealing a fitting portion with the cap 18. The cap 18 can be detachably attached to the housing 11 by friction fitting, detent, or the like.

  A portion of the housing 11 covered with the cap 18 when the cap 18 is fitted to the housing 11 is mounted with a puncture member including the puncture needle holder 68 and the puncture needle 70, and the puncture member is used for collecting a biological sample. A puncture member opening 67 for moving through the skin when puncturing the skin, and a biosensor mounting opening 66 for mounting a biosensor 69 for measuring a biological component in the collected biological sample. Is provided.

  The housing 11 is equipped with an assembly for projecting the puncture member through the puncture member opening 67 (not shown). As such an assembly, for example, a known assembly using air pressure, a spring, or the like as described in JP-A-2001-346781 can be used. The housing 11 further includes a vacuum pump, an electric device, a battery and the like (not shown) for operating such an assembly.

  The housing 11 further includes a slot (or mounting portion) (not shown) for detachably mounting the biosensor 69 through the opening 66. The biosensor 69 is usually a disposable type. The biosensor 69 includes one or more electrical contacts (not shown) on the end inserted into the slot and engages with one or more electrical contacts (not shown) disposed within the slot. Yes. Further, in the housing 11, a CPU (not shown) for performing data processing and the like connected to such an electrical contact with an electric circuit, and a data storage unit (not shown) including a RAM, a ROM, an external storage device, or the like. ) Is equipped.

  On the other hand, the cap 18 is provided with an opening 17 for collecting a biological sample. Through this hole, a puncture member including a puncture needle attached to the puncture member opening 67 of the housing 11 protrudes, and the subject's It is designed to puncture the skin. The surface where the cap 18 comes into contact with the living body, that is, the living body contact portion 19 has a curved surface that fits the shape of each collection site. For example, the living body contact portion 19 of the cap 18 of FIG. 1 is designed to have a curved surface that fits well on the ventral side of the fingertip when a finger is attached.

  At the time of use, the measuring device 1 is arranged so that the biological contact portion 19 is in close contact with the skin surface of the sample collection site of the subject who collects the biological sample. At this time, a seal (not shown) made of an elastic body such as rubber or elastomer is provided around the opening 17 so that the biological sample collection opening 17 is sealed by contact with the skin. preferable.

  As shown in the figure, the switch 13 is usually formed by a push button or the like, and the measurement operation is started by pressing the button. Specifically, when the switch 13 is pressed, the stopper that stops the puncture member mounted in the housing 11 is released, and the puncture member attached in the housing 11 is moved by a mechanism based on mechanical energy such as a spring. Protrude and puncture the fingertip. Preferably, when the switch 13 is pressed, the above-described vacuum pump, electronic device, etc. (not shown) in the housing 11 are operated to draw a vacuum, so that the skin surrounded by the opening 17 is against the opening 17. The skin is congested, and the skin is punctured by the puncture needle provided on the puncture member. Such puncture is usually performed by operating the above-described puncture member assembly (not shown) after an appropriate time set in advance by an electronic device incorporating a program.

  After the puncture, the slot in which the biosensor 69 is mounted is moved in the direction of the punctured skin, and the biosensor 69 provided in the measuring device 1 is brought into contact with the blood exuded from the fingertip, whereby a biological component (here, glucose) Measure the concentration. As the mechanism for moving the slot, for example, a known slide mechanism as described in JP-A-2001-346781 can be used. Moreover, the start of the operation of the slot can be linked with the end of the operation of the puncture assembly. In addition, if the position of the slot and the biosensor 69 is set in advance in the measurement device 1 so that the blood exuded to contact the tip of the biosensor 69 attached to the slot, the mechanism for moving the slot is not necessarily measured. It is not necessary to provide the device 1.

  The biosensor 69 is a reagent containing at least a pair of electrodes, a glucose dehydrogenase that reacts specifically with glucose in blood, and an electron carrier, which are supported on the sample container, which is in contact with the biological sample. When the blood is stored in the sample storage part of the biosensor, this reagent system reacts with glucose in the blood. While applying a voltage from the measurement unit (not shown) of the measurement device 1 to the electrode system of the biosensor 69, the current value including the change in the current value due to the reaction is obtained as the biological component information input unit (not shown) of the measurement device 1 and By measuring with a CPU (not shown), the amount of the electron carrier is measured electrochemically to obtain a blood glucose level.

  The obtained measurement result is stored in a storage unit (not shown) as data of a biological sample (blood) collected from the fingertip and displayed on the display unit 12.

  On the other hand, FIG. 2 is a schematic view showing an external appearance of the puncture device integrated biological component measuring apparatus 2 of the present invention provided with a cap 28 adapted to collect a biological sample from the forearm. FIG. 2 shows a state in which the cap 28 is fitted to the housing 11. In FIG. 2, the difference from the configuration shown in FIG. 1 is that the biological contact portion 29 of the cap 28 has a shape suitable for collecting a biological sample from the forearm portion. It has a shape that fits well when pressed against the skin of the subject's forearm (usually a curved surface with a larger diameter than that for fingers). The cap 28 is provided with an opening 27 for collecting a biological sample corresponding to the opening 17 shown in FIG. 1, and the puncture member opening 67 (FIG. 1B) of the housing 11 is formed through this hole. The puncture member mounted on (see) protrudes and punctures the skin of the subject. The cap 28 can be detachably attached to the housing 11 as in the case of FIG. The external view with the cap 28 removed and the description thereof are the same as in the case of FIG.

  As described above, the caps (18, 28) shown in FIGS. 1 and 2 are designed to fit the shape of each collection site of the biological sample, and are detachably attached to the housing 11. Can do. Therefore, when the user changes the collection site of the biological sample, the user only needs to replace the cap (18, 28) suitable for the collection site. In this way, a biological sample can be collected from a plurality of different sites with one measuring device. Here, the case of collecting with the fingertip and forearm is taken as an example, but the present invention is not limited to these, and the caps (18, 28) may be other biological sample collection sites (for example, palms). , Upper arms, thighs, abdomen, etc.) can be used.

  As apparent from FIGS. 1 and 2 and the above description, the caps (18, 28) protect the puncture needle except during puncture.

  Blood glucose measurement from other than fingertips has been performed in recent years because it has the advantage of less pain or no damage to the fingertips. It has been pointed out that there may be a discrepancy between the blood glucose level and the forearm blood glucose level. In such a case, it is recommended to measure from the fingertip even if the person is usually measuring from the forearm.

  In such a situation, there is no need to change the measuring device main body for each measuring site, and the measuring device of the present invention, which can measure from a plurality of sampling sites with a single measuring device by simply changing the cap, is useful for the user. Convenient.

  The shape of the biological component measuring apparatus according to the present embodiment shown in FIG. 1 or FIG. 2 is merely simplified for the sake of explanation, and is not intended to be limited to such a box-type one. Of course, other shapes (for example, a cylindrical shape, a flat shape, a pen shape, etc.) that can be easily grasped with a finger may be used (the same applies to the embodiments described below).

(Embodiment 2)
Next, a second embodiment of the present invention will be described with reference to FIGS.

  FIG. 3 is a schematic diagram showing an external appearance of a puncture device-integrated biological component measuring apparatus 3 having a cap recognition mechanism (including terminals 61, 62, 63, 64, and a constant resistance 65). The biological component measuring apparatus 3 of the present invention includes a housing 31 made of a material such as plastic that houses the apparatus main body and constitutes a part thereof, and a cap 38 that can be detachably attached thereto. FIG. 3 shows a state where the fingertip cap 38 is removed from the housing 31.

  The biological component measurement apparatus 3 shown in FIG. 3 further includes a cap recognition mechanism at the fitting portion between the housing 31 and the cap 38. Further, the housing 31 includes a storage unit (see 102 in FIG. 4) for storing data and a timer (not shown) for measuring the measurement time. Since the other points are basically the same as those shown in FIG. 1, detailed description will be omitted below.

  In FIG. 3, a housing 31 is provided with a display unit 32 constituted by a liquid crystal digital display or the like for displaying results such as biological component concentrations measured by a biosensor, and a switch 33 for starting measurement. It has been. In addition, the housing 31 is provided with a biosensor 69, a biosensor mounting opening 66, a puncture needle holder 68 and a puncture needle 70, and a puncture member opening 67. The housing 31 also includes a gasket 34 (another sealing mechanism may be used) for sealing a fitting portion with the cap 38.

  The cap 38 can be detachably attached to the housing 31 by friction fitting, detent, or the like. The cap 38 includes a living body contact portion 39 designed to have a curved shape that fits well when applied to a fingertip, and a living body sample collection opening portion 37. In addition, since the cap 38 is detachable, the living body contact portion 39 is designed for a portion other than the fingertip (for example, forearm or thigh) according to the collection site (for example, the living body contact shown in FIG. 2). Such as section 29) may be used.

  In Embodiment 2 of the present invention, the housing 31 is further provided with a concave portion 35a for fitting with the convex portion 35b of the cap 38 when the cap 38 is attached. Terminals (61, 62) made of a conductor such as copper are provided in the concave portion 35a of the housing 31, and when the cap 38 is fitted into the housing 31, the convex portion 35b is connected to the concave portion 35a of the housing. Similarly conductive terminals (63, 64) provided on the contact surface come into contact with each other.

  In the convex portion 35 b of the cap 38, a constant resistance 65 unique to the cap 38 is provided between the terminal 63 and the terminal 64 and electrically connected thereto.

  On the other hand, the terminal 61 and the terminal 62 on the recess 35 a of the housing 31 are connected to a resistance measuring device (not shown) provided inside the housing 31. When the cap 38 is mounted on the housing 31, the resistance measuring device contacts the terminals 61 and 62 on the concave portion 35 a with the terminals 63 and 64 on the convex portion 35 b to form a circuit. The resistance value is detected and sent to the CPU (see 101 in FIG. 4) of the measuring device 3 also provided in the housing 31. The CPU refers to data (not shown) in which the resistance value of the constant resistance stored in advance in the storage unit in the housing 31 (see 102 in FIG. 4) is assigned to a specific collection site, and collects a biological sample collection site. (In this example, a fingertip) can be recognized.

  In this way, the information on the sample collection site is stored together with the measurement value in the storage unit (see 102 in FIG. 4) provided in the housing 31, and is displayed on the display unit 32 together with the measurement value as necessary. The Furthermore, if necessary, information on the measurement time measured by a timer (not shown) built in the housing 31 is stored in the storage unit together with the measurement value.

  Thus, according to the present invention, it is possible to collect a biological sample from a plurality of different parts with one measuring device, and further, information on the sampled collecting part together with measured values of biological components in the sample is stored in the measuring apparatus. It can be stored and / or displayed. Thereby, the user can simultaneously recognize the measurement value and the sample collection site in the biological component measurement apparatus of the present invention. Furthermore, since the user can correct the measurement value based on the information of the sample collection site and the collection time as necessary, the user can know the blood glucose level of the subject more accurately. The blood glucose control of the subject can be made more reliable.

  In this embodiment, since it has a memory | storage part (refer 102 of FIG. 4), the blood glucose level recorded for every time series is also recorded together with the information on the collection position. Therefore, the subject's blood glucose fluctuation state can be grasped more accurately, and treatment aimed at improving blood glucose can be more reliably performed.

  FIG. 4 is a block diagram showing the overall configuration of the biological component measuring apparatus 3 according to the second embodiment of the present invention (however, the cap 38 and the puncture member are omitted). The biological component measurement apparatus 3 includes a CPU 101, a storage unit 102, a biological component information input unit 103 for inputting biological component information from the biosensor 69, a collection part input unit 104 for inputting a biological component collection part, and a display. The unit 32 is provided. Furthermore, the biological component measuring device 3 includes a timer (not shown) for inputting time.

  The biological component information input unit 103 includes a slot (not shown) for mounting the biosensor 69, an electrical contact (not shown) provided in the slot that engages with a terminal of the biosensor 69, and the electrical An electrical circuit (not shown) is connected to the contactor to convert the current value from the biosensor 69 into a voltage pulse and input it to the CPU 101. Information on the substrate concentration from the biosensor 69 is stored in the CPU 101. To enter. In the biological component information input unit 103, a drive power source for applying a voltage to the measurement electrode of the biosensor under the control of the CPU 101, and a current generated by the contact between the measurement electrode of the biosensor and the sample are converted into a voltage. Current / voltage conversion circuit (not shown), an A / D conversion circuit (not shown) for converting a voltage value from the current / voltage conversion circuit into a pulse, and the like.

  On the other hand, the collection part input unit 104 is electrically connected to the recess 35a provided in the housing 31, the terminal 61 and the terminal 62 (see FIG. 3) provided thereon, and the CPU. A resistance measuring device (not shown) or the like connected to, and the like, a resistance value specific to the cap 38 (see FIG. 3) is detected and input to the CPU 101.

  The storage unit 102 includes a storage medium such as a RAM, a ROM, or an external storage device, and stores information from the biological component information input unit 103, the collection site input unit 104, the CPU 101, and the like.

  The display unit 32 includes a display device such as a liquid crystal digital display, and displays information such as measurement results, measurement times, and measurement sites.

  FIG. 5 is a flowchart showing the processing operation of the CPU 101 in the measuring apparatus shown as an overall configuration in FIG.

  The processing operation illustrated in FIG. 5 is started by a user operation such as pressing or touching the switch 33. When the user's operation is performed on the switch 33, the CPU 101 operates the puncture mechanism of the measurement device 3, punctures the skin of the measurement site of the subject, and exudes blood. In step S <b> 11, the CPU 101 acquires an electrical signal including information related to the concentration of the biological component (substrate) from the biosensor 69 via the biological component information input unit 103. Specifically, the biosensor 69 comes into contact with the blood sample exuded by puncturing, and the blood sample is stored in the sample storage portion of the biosensor 69. After sufficient blood is stored, a voltage is applied between the measurement electrodes of the biosensor 69 to obtain an electrical signal containing information on the substrate concentration from the biosensor 69. Next, in step S12, the CPU 101 calculates the concentration of the substrate based on the signal. In the calculation of the substrate concentration, for example, by applying an algorithm stored in advance in the storage unit 102, it can be related to the concentration of the substrate in the sample. In step S13, the CPU 101 acquires a specific collection site based on the collection site information (for example, the resistance value of the constant resistance 65) input via the collection site input unit 104, and in step S14, the calculated concentration and the specification are specified. The collected part is stored in the storage unit 102.

  In step S15, it is determined whether or not such information is to be displayed. If the information is to be displayed (S15: Yes), the display unit 32 displays the result in step S16, and then ends the process. When not displaying (S15: No), a process is complete | finished. Here, the determination of whether or not to display may be configured to depend on a user operation, for example. For example, a display button (not shown) or the like may be provided in the measurement apparatus 3 so that the user selects display / non-display by pressing the button. It should be noted that all the measurement results may be displayed without providing such a display / non-display determination step (step S15).

  In this way, the measurement result and the sample (here, blood) collection site can be associated with each other. By associating the measurement result with the blood collection site and recording it in the storage unit, the measurement data can be used more effectively when the blood glucose level of the subject is managed. If necessary, when the calculated concentration and the collection site are stored in the storage unit 102 in step S14, the collection time may also be stored. Thereby, time series analysis of the measured value becomes possible.

  In the present embodiment, the puncture member and the biosensor are separately accommodated in the measurement device, but a device in which the puncture member and the biosensor are integrated may be used.

  In the second embodiment, blood is collected using the cap 38 having a shape that closely matches the surface of the blood collection site and the cap recognition mechanism (61, 62, 63, 64, and 65) of the housing 31. Although the site has been recognized, the method for recognizing the collection site is not limited to this.

  For example, as shown in FIG. 6, a plurality of sensors (81, 82, 83, and 84) that sense the contact state of the skin around the biological sample collection opening 47 provided in the biological contact portion 49 of the cap 48 are provided. ) And the blood collection site may be recognized by a combination of signals sensed by these sensors.

  More specifically, the cap 48 includes a living body contact portion 49 having a substantially flat surface at the top thereof. As shown in FIG. 6, the living body contact portion 49 has a top portion of the cap 48 so that it can accommodate both a relatively small portion of the contact surface such as a fingertip and a relatively large portion of the contact surface such as the forearm. It is preferable to have a relatively small plane. The biological contact portion 49 is provided with sensors 81, 82, 83, and 84 for detecting contact with the skin. Here, for example, when a blood sample is collected from the fingertip, since the contact area of the skin with respect to the living body contact portion 49 is small, only a part of the four sensors (for example, the sensor 81 and the sensor 83) is the skin. Senses contact with. On the other hand, when a blood sample is collected from the forearm, since the contact area of the skin with respect to the living body contact portion 49 is relatively large, all four sensors (sensors 81, 82, 83, and 84) sense contact with the skin. .

  Here, the sensors (81, 82, 83, and 84) are connected to a CPU (not shown) in the housing 41 of the measuring device, and the CPU receives a contact detection signal with the skin from all four sensors. If the sampling site is determined to be the forearm, and a contact detection signal with the skin is received from only a part of the four sensors (for example, two sensors (for example, sensors 81 and 83)), By setting so as to determine that the sampling part is the fingertip, it is possible to input information on the sampling part. Examples of such a sensor for detecting the contact state of the skin include a touch sensor, a tactile sensor, a method of measuring a change in resistance using an electrode, and a method of installing a light source and measuring the reflected light. However, it is not limited to these. Connection between the sensors (81, 82, 83 and 84) and the CPU inside the housing 41 is performed by providing an electrical contact or the like at the fitting portion between the cap 48 and the housing 41, as shown in FIG. be able to. Further, the sensor may be provided not on the cap 48 but on the housing 41 side. In that case, the cap 48 may be provided with openings (not shown) for these sensors.

  It should be noted that the number of sensors to be provided is usually two or more, and is not limited to four as in the above example.

  Alternatively, in another method for recognizing a collection site, for example, a plurality of input switches can be used as a collection site input means. Specifically, for example, a forearm selection switch and a fingertip selection switch (not shown) connected to the CPU inside the housing are provided in the housing of the apparatus main body (not shown). By pressing any of the switches, the measurement operation can be started and the sample collection site can be input. Such a switch can be like a push button. Note that the measurement start switch may be provided separately from these sampling site input switches, or these switches may also be used as the measurement start switch.

(Embodiment 3)
A third embodiment of the present invention will be described with reference to FIGS.

  As described above, the blood glucose level fluctuates greatly depending on the blood collection site immediately after the measurer eats a meal. In such a case, the measurement value at the forearm often takes a behavior of blood glucose fluctuation delayed by a certain time compared with the measurement value at the fingertip (John M. ELLISON, Diabetes Care vol 25, No. 6, 961-964). , (2002)). Therefore, it is conceivable that a correction formula is created in advance based on the results measured under such conditions so that the blood sugar level in the forearm can be corrected according to the elapsed time after the meal.

  As an example of the measurement value under such conditions, here, the measurement value at the fingertip before and after the meal and the measurement value at the forearm described in the above-mentioned John M. ELLISON (2002) are used. In John M. ELLISON (2002), there is almost no difference between the measured value on the fingertip and the measured value on the forearm when fasting, but the measured value on the fingertip is 60, 90, and 120 minutes after meal. It is described that the measured values are higher by about 10%, about 8%, and about 2% than the measured values at 1. At 150 minutes after eating, there is almost no difference between the measured values at the fingertips, but at 180 minutes after eating, the measured values at the fingertips are about 5% lower than the measured values at the fingertips. Therefore, for example, when measurement is performed with blood collected from the forearm 60 minutes after a meal, the measurement result obtained from the fingertip can be estimated by increasing the obtained result by about 10%. On the other hand, at 180 minutes after the meal, the measurement result from the blood collected from the forearm is lowered by about 5%, so that the measurement value from the fingertip can be estimated. Note that this data is only an example, and there may be other correction degrees depending on the subject.

  Such correction can be performed, for example, by multiplying an actual measurement value by a correction coefficient as shown in FIG. FIG. 7 shows the time dependency of the correction coefficient obtained based on the data of John M. ELLISON (2002). In the figure, the vertical axis (y-axis) indicates a correction coefficient for correction of a blood sample collected by the forearm, and the horizontal axis (x-axis) indicates an elapsed time after a meal. Here, the correction coefficient is assumed to be expressed by a linear function after meal, but is not intended to be limited to this, and may be expressed by other functions (for example, a quadratic function, an exponential function, etc.). A correction value can be obtained by multiplying the measured value of the blood glucose concentration from the forearm measured at each elapsed time after the meal by the correction coefficient shown in the graph of FIG. For example, if the measured value of glucose concentration in the forearm 60 minutes after meal is 70 mg / dl, the correction coefficient in FIG. 7 is used, and the correction coefficient (= 1.11) at 60 minutes is multiplied. Thus, 77.4 mg / dl is the corrected value.

  Alternatively, a correction table based on experimental data may be created in advance, and the correction rate may be determined by applying the blood sample collection site and the time after meal. The experimental data is preferably acquired for each subject.

  In this way, by correcting the result of blood collection at a site other than the fingertip (for example, the forearm) according to the elapsed time after the meal, it can be compared with the blood glucose level measured for blood collected from the fingertip. The blood glucose level can be accurately monitored without depending on the time or measurement site. Hereinafter, an embodiment in which such an operation is performed in a measurement apparatus will be described in detail with reference to the drawings.

  FIG. 8 is a schematic diagram showing a configuration of the biological component measuring apparatus 5 according to Embodiment 3 of the present invention, which can input an elapsed time after a meal. In the figure, the measuring device 5 includes a housing 51 and a cap 38. The difference between the measuring apparatus shown in FIG. 8 and the measuring apparatus shown in FIG. 3 is that the measuring apparatus 5 shown in FIG. 8 includes a meal time input unit 36 that is a means for inputting the time after meal. It is. Since the other part is the same as that of FIG. 3, description is abbreviate | omitted.

  The meal time input unit 36 is configured by a push-type button that can input numbers from 0 to 9, for example, in order to input the time when the user eats or the elapsed time after the meal. Any other input means such as a touch panel may be used as long as it can input meal time or elapsed time after meal.

  The third embodiment of the present invention will be further described with reference to FIG. FIG. 9 is a block diagram showing the overall configuration of the biological component measuring apparatus according to Embodiment 3 of the present invention whose outline is shown in FIG. 8 (however, the cap 38 and the puncture member are omitted). . 4 is different from the block diagram shown in FIG. 4 in that the meal time input unit 36 is further included, and the storage unit 202 corrects the measurement value based on the elapsed time after the meal and the sampling part. The correction formula or correction table is stored.

  When the user inputs a meal time via the meal time input unit 36, the information is transmitted to the CPU 101 and further recorded in the storage unit 202 as necessary. This meal time information is used to correct the substrate concentration in the sample measured by the biosensor in accordance with the elapsed time after the meal. Instead of inputting the meal time, the elapsed time after the meal may be directly input.

  The storage unit 202 includes a storage medium such as a ROM, a RAM, or an external storage device, and stores information from the biological component information input unit 103, the collection site input unit 104, the meal time input unit 36, the CPU 101, and the like. Further, the storage unit 202 includes a correction formula or correction table stored in advance for correcting the measured value according to the elapsed time after the meal and the sampling site.

  FIG. 10 is a flowchart showing the processing operation of the CPU 101 in the measuring apparatus shown in FIG.

  The processing operation illustrated in FIG. 10 is started by a user operation such as pressing or touching the switch 33. When the user's operation is performed on the switch 33, the CPU 101 operates the puncture mechanism of the measurement device 5, punctures the skin of the measurement site of the subject, and exudes blood. In step S <b> 21, the CPU 101 acquires an electrical signal including information on the concentration of the biological component (here, glucose) from the biosensor 69 via the biological component information input unit 103. Specifically, the biosensor 69 comes into contact with the blood sample exuded by puncturing, and the blood sample is stored in the sample storage portion of the biosensor 69. After sufficient blood is stored, a voltage is applied between the measurement electrodes of the biosensor 69 to obtain an electrical signal containing information on the substrate concentration from the biosensor 69. Next, in step S22, the CPU 101 calculates the concentration of the substrate based on the signal. In calculating the substrate concentration, for example, by applying an algorithm stored in advance in the storage unit 202, the substrate concentration can be related to the sample. In step S <b> 23, the CPU 101 acquires the collection part information (for example, the resistance value of the constant resistance 65) input via the collection part input unit 104 and recognizes a specific collection part.

  In step S24, it is determined whether or not the collection site is the fingertip. If it is the fingertip (S24: Yes), the calculated concentration and the specified collection site in step S27 are stored in the storage unit 202. Next, in step S28, it is determined whether or not to display such information. If the information is to be displayed (S28: Yes), the result is displayed on the display unit 32 in step S29, and then the process ends. When not displaying (S28: No), a process is complete | finished. Here, the determination of whether or not to display may be configured to depend on a user operation, for example. For example, a display button (not shown) or the like may be provided in the measurement device 5 so that display / non-display is selected by the user pressing the button. Note that all the measurement results may be displayed without providing such a display / non-display determination step (step S28).

  On the other hand, if the collection site is other than the fingertip (eg, forearm) in step S24 (S24: No), the elapsed time after meal is acquired in step S25, and then the correction formula stored in the storage unit 202 in step S26. The correction coefficient or the correction rate is obtained with reference to the correction table (for example, as shown in FIG. 7), and the measurement value corrected based on the time after the meal is obtained using the correction coefficient or the correction rate. Since the correction coefficient or the correction rate often varies depending on the subject, it is preferable to obtain the correction factor or the correction rate individually for each subject. Next, the corrected measurement value is stored in the storage unit 202 together with the collected part information in step S27. Next, in step S28, it is determined whether or not to display such information. When the information is displayed (S28: Yes), the result is displayed on the display unit 32 in step S29, and then the process ends. When not displaying (S28: No), a process is complete | finished.

  As described above, in the third embodiment, compared to the case of sampling at the fingertip depending on the time after meal, as in the case of measuring the blood glucose level of blood sampled at a site other than the fingertip such as the forearm, When there is a difference in the measured substrate concentration, correct the substrate concentration in the sample sampled at a site other than the fingertip using the correction coefficient as described above, and then It can be made comparable with other measurement results.

  Thereby, it is possible to accurately monitor the substrate concentration (for example, blood glucose level) regardless of the sampling site, and as a result, it is possible to perform a more appropriate treatment for the subject.

  In the above example, the measurement value at the part other than the fingertip is corrected with respect to the measurement value at the fingertip. However, the optimum measurement value is selected according to the purpose. Can do.

  Further, in the above example, as an input method of the collection part information, the form using the collection part recognition mechanism provided in the fitting part between the cap and the apparatus main body is shown, but it is not intended to be limited to this, For example, other forms such as a form using a sensor as shown in FIG. 6 or a form using an additional switch or switches for inputting a collection site may be used.

  Although the present invention has been described in detail above, the above description is merely illustrative of the present invention in all respects and is not intended to limit the scope thereof. It goes without saying that various improvements and modifications can be made without departing from the scope of the present invention.

  As a material of the cap in the first to third embodiments, plastic or the like is preferable. If the part that comes into contact with the living body is made of an elastic material such as rubber, the adhesion to the skin is improved and the measurement can be performed more reliably.

  The biosensor in the above first to third embodiments may be any sensor that can identify or quantify a specific component in a biological sample. The measurement method may be electrochemical or optical.

  As an example of the biosensor shown in the first to third embodiments, glucose oxidase or glucose dehydrogenase that specifically reacts with glucose as an enzyme, potassium ferrocyanide as an electron carrier, and electrochemical using an electrode Some quantitate glucose by obtaining a typical signal response. It is not limited to these enzymes and electron carriers.

  As the oxidoreductase, those corresponding to the substrate to be measured contained in the biological sample are used. For example, fructose dehydrogenase, alcohol oxidase, lactate oxidase, cholesterol oxidase, cholesterol dehydrogenase, xanthine oxidase, amino acid oxidase, etc. Can be mentioned.

  Examples of the electron carrier include p-benzoquinone, phenazine methosulfate, methylene blue, and ferrocene derivatives. A current response can also be obtained when oxygen is used as an electron carrier. One or more of these electron carriers are used.

  In the first to third embodiments described above, the collection site of the biological sample is shown for the fingertip and the forearm, but is not limited thereto. For example, the palm, upper arm, thigh, abdomen, and the like may be used as the collection site. The palm may be the base of the thumb or the little finger ball.

  In the case of measurement using a cap, the shape of the cap may be determined in accordance with the shape of each collection site.

  In the above embodiment, whole blood is used as a biological sample. However, the present invention is not limited to this as long as the sample contains a test substance whose measured value varies depending on the collection site and the collection time. Further, the substrate (measuring object) is not limited to glucose. For example, it can be applied to other substrates contained in other biological samples such as interstitial fluid, saliva, sweat, urine, bone marrow fluid.

  Since the biological component measuring device of the present invention associates the collection site of the biological sample with the measurement result, it enables a more accurate interpretation of the measured value, and thus the biosensor measuring device for accurate monitoring of the condition of the subject Useful as such.

Schematic which shows the external appearance of the puncture device integrated biological component measuring device provided with the cap 18 suitable for the blood collection from the fingertip based on one Embodiment of this invention. (A) A state where the cap 18 is fitted to the housing 11; (B) a state where the cap 18 is removed. Schematic diagram showing the appearance of a puncture device integrated biological component measuring apparatus 2 having a cap 28 adapted to collect a biological sample from a forearm according to an embodiment of the present invention. Schematic which shows the external appearance of the puncture device integrated biological component measuring apparatus 3 provided with the cap recognition mechanism (Including terminal 61, 62, 63, 64 and the constant resistance 65) based on one Embodiment of this invention. The block diagram which shows the whole structure of the biological component measuring apparatus 3 based on one Embodiment of this invention (however, the cap 38 and the puncture member are abbreviate | omitted). The flowchart which shows the processing operation of CPU101 in the measuring apparatus shown as a whole structure in FIG. Schematic which shows the external appearance of the biological component measuring apparatus 4 provided with the cap which has the biological contact part which has arrange | positioned the sensor which detects the contact state of skin based on one Embodiment of this invention. A graph showing the time dependence of the correction coefficient for correcting the measured value based on the elapsed time after meal Schematic which shows the external appearance of the biological component measuring apparatus 5 which concerns on one Embodiment of this invention which can input the elapsed time after a meal. The block diagram which shows the whole structure of the biological component measuring apparatus which concerns on one Embodiment of this invention shown in FIG. FIG. 9 is a flowchart showing the processing operation of the CPU 101 in the measuring apparatus shown as the overall configuration in FIG. Schematic diagram of conventional biosensor for glucose measurement

Explanation of symbols

1, 2, 3, 4, 5 Biological component measuring device 11, 31, 41, 51 Housing 12, 32, 42 Display unit 13, 33, 43 Switch 14, 34 Gasket 17, 27, 37, 47 Opening for collecting biological sample Portions 18, 28, 38, 48 Caps 19, 29, 39, 49 Living body contact portion 35a Recess portion 35b Protrusion portion 36 Meal time input portions 61, 62, 63, 64 Terminal 65 Constant resistance 66 Biosensor mounting opening 67 Puncture member Opening 68 puncture needle holder 69 biosensor 70 puncture needle 81, 82, 83, 84 Contact detection sensor 101 CPU
102, 202 Storage unit 103 Biological component information input unit 104 Collection site input unit

Claims (13)

A biocomponent measurement device set in which a puncture mechanism for puncturing a subject's skin and collecting sample blood and a biosensor measurement device are integrated,
The puncture mechanism is at least
A puncture needle,
A cap that is detachably fitted to the apparatus body,
Here, the cap is a skin contact surface that comes into contact with the skin at the time of puncturing, has an opening through which the puncture needle passes therethrough and punctures the skin, and the skin surface to be punctured A skin contact surface having a shape that fits the shape of
A biological component measuring device set comprising a plurality of caps that differ depending on the sample collection site so that a plurality of different sample collection sites can be selected.   The biological component measuring device set according to claim 1, comprising a cap for collecting a sample from a fingertip and a cap for collecting a sample from a forearm.   The biological component measuring device set according to claim 2, further comprising a cap for collecting a sample from any part selected from the group consisting of a palm, an upper arm, a thigh, and an abdomen. The biosensor measuring device is
A biocomponent information input unit for inputting measurement information from the biosensor, including a biosensor mounting unit;
A sample collection part input unit for inputting information of a sample collection part;
A storage unit;
A calculation unit for calculating a substrate concentration in the sample blood based on information from the biological component information input unit;
A display unit for displaying the calculated substrate concentration,
The biological component measuring device set according to claim 1, wherein the information on the sample collection site inputted together with the calculated substrate concentration is recorded in the storage unit.   The biological component measuring device set according to claim 4, wherein the biosensor is a glucose sensor.   The biological component measuring device set according to claim 4, wherein the input information on the sample collection site is displayed on the display unit together with the calculated substrate concentration. The cap includes a pair of electrical contacts electrically connected to a constant resistance specific to the cap at least part of the fitting portion with the apparatus main body,
The sample collection site input unit is a resistance measuring instrument and a second pair of electrical contacts electrically connected to the resistance measuring instrument, and when the cap is fitted to the apparatus main body, A second pair of electrical contacts that form an electrical circuit in contact with the pair of electrical contacts, with the result that the resistance measuring device detects the constant resistance value;
The biological component measuring device set according to claim 4, wherein a sample collection site is recognized based on the detected constant resistance value. The biosensor measurement device further includes a meal time input unit for inputting a meal time or an elapsed time after the meal,
The storage unit stores in advance a correction table or a correction formula for correcting the measurement value based on the elapsed time after the meal and the sample collection site,
The calculation unit is stored in the storage unit based on the meal time input to the meal time input unit or the elapsed time after the meal and the sample collection site input to the sample collection site input unit. The biological component measuring device set according to claim 4, wherein the corrected substrate concentration is calculated with reference to the correction table or the correction formula. A biocomponent measurement device in which a puncture mechanism for puncturing a subject's skin and collecting sample blood is integrated with a biosensor measurement device,
The puncture mechanism is at least
A puncture needle,
A cap that is detachably fitted to the apparatus body,
Here, the cap is a skin contact surface that comes into contact with the skin at the time of puncturing, and includes a skin contact surface having an opening through which the puncture needle passes and punctures the skin,
The biosensor measuring device is
A biocomponent information input unit for inputting measurement information from the biosensor, including a biosensor mounting unit;
A sample collection part input unit for inputting information of a sample collection part;
A calculation unit for calculating a substrate concentration in the sample blood based on information from the biological component information input unit;
A storage unit for recording the input information of the sample collection site together with the calculated substrate concentration,
A display unit for displaying the calculated substrate concentration,
Here, the skin contact surface of the cap includes at least two sensors for sensing a contact state with the skin that can be electrically connected to the sample collection site input unit when fitted to the apparatus main body,
The biological component measuring apparatus, wherein the sample collection site input unit recognizes a sample collection site according to the number and / or combination of the sensors that sense a contact state.   The biological component measuring apparatus according to claim 9, wherein the sample collection site input unit recognizes the sample collection site as a fingertip when only a part of the sensor senses contact with the skin.   The sample collection part input unit recognizes the sample collection part as any part selected from the group consisting of a palm, a forearm, an upper arm, a thigh, and an abdomen when all of the sensors detect contact with the skin. The biological component measuring apparatus according to claim 9, wherein: The biosensor measurement device further includes a meal time input unit for inputting a meal time or an elapsed time after the meal,
The storage unit stores in advance a correction table or a correction formula for correcting the measurement value based on the elapsed time after the meal and the sample collection site,
The calculation unit is stored in the storage unit based on the meal time input to the meal time input unit or the elapsed time after the meal and the sample collection site input to the sample collection site input unit. The biological component measuring apparatus according to claim 9, wherein the corrected substrate concentration is calculated with reference to the correction table or the correction formula. A biosensor measuring device comprising:
A biocomponent information input unit for inputting measurement information from the biosensor, including a biosensor mounting unit;
A sample collection part input unit for inputting information of a sample collection part;
A calculation unit for calculating a substrate concentration in the sample blood based on information from the biological component information input unit;
A storage unit for recording the input information of the sample collection site together with the calculated substrate concentration,
A display for displaying the substrate concentration ;
Bei example and meal time in order to enter the meal time or elapsed time after a meal input section,
The storage unit stores in advance a correction table or a correction formula for correcting the measurement value based on the elapsed time after the meal and the sample collection site,
The calculation unit is stored in the storage unit based on the meal time input to the meal time input unit or the elapsed time after the meal and the sample collection site input to the sample collection site input unit. Referring to the correction table or the correction formula, calculate the corrected substrate concentration,
The storage unit further stores the corrected substrate concentration,
The biosensor measurement apparatus , wherein the display unit displays the corrected substrate concentration .

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